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https://www.readbyqxmd.com/read/29044473/induced-pluripotent-stem-cells-from-ovarian-tissue
#1
Sophia Salas, Nicholas Ng, Behzad Gerami-Naini, Raymond M Anchan
Yamanaka and colleagues revolutionized stem cell biology and regenerative medicine by observing that somatic cells can be reprogrammed into pluripotent stem cells. Evidence indicates that induced pluripotent stem (iPS) cells retain epigenetic memories that bias their spontaneous differentiation into the originating somatic cell type, therefore epigenetic memory may be exploited to improve tissue specific regeneration. We recently showed that iPS cells reprogrammed from ovarian granulosa cells using mouse and human tissue overwhelmingly differentiate homotypically into ovarian steroidogenic and primordial germ cells...
October 18, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/29044180/evaluating-phenotype-driven-approaches-for-genetic-diagnoses-from-exomes-in-a-clinical-setting
#2
Reuben J Pengelly, Thahmina Alom, Zijian Zhang, David Hunt, Sarah Ennis, Andrew Collins
Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to prioritise variants as potentially causal. Some methods have a clinical focus while others are more research-oriented. With clinical applications in mind we compare results from alternative methods using 21 exomes for which the disease causal variant has been previously established through traditional clinical evaluation...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29032748/mechanistic-understanding-of-herbal-therapy-in-inflammatory-bowel-disease
#3
Luqing Zhao, Shengsheng Zhang, Peijian He
The incidence and prevalence of inflammatory bowel diseases (IBD), which comprise ulcerative colitis and Crohn's disease, are increasing dramatically worldwide. Immunomodulators and biological agents can help but cause severe side effects in long-term use. As such, complementary and alternative medicine, in particular herbal remedy, is becoming more and more popular in the treatment of IBD patients. Many natural compounds have been used in clinical trials and some have been proven promising in IBD treatment...
October 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29030882/accelerated-multicontrast-volumetric-imaging-with-isotropic-resolution-for-improved-peri-infarct-characterization-using-parallel-imaging-low-rank-and-spatially-varying-edge-preserving-sparse-modeling
#4
Li Zhang, Peng Lai, Mihaela Pop, Graham A Wright
PURPOSE: To achieve consistent effectiveness in reconstruction of fine image features for cases of varying contrast-to-noise ratio (CNR) to facilitate translating accelerated multicontrast volumetric imaging with isotropic resolution toward clinical utility in peri-infarct characterization. THEORY AND METHODS: A low-rank and spatially varying edge-preserving constrained compressed sensing parallel imaging reconstruction method (CP-LASER) is developed to effectively preserve contrast of small-scale structures for highly accelerated multicontrast volumetric imaging in CNR-limited scenarios...
October 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29028779/an-investigation-of-the-use-of-traditional-chinese-medicine-and-complementary-and-alternative-medicine-in-stroke-patients
#5
Mei-Ling Yeh, Wei-Ling Chiu, Yu-Jen Wang, Chyi Lo
This study aimed to investigate the use of traditional Chinese medicine and complementary and alternative medicine in stroke patients in Taiwan. Chinese herbal medicine, massage, acupuncture, natural products, and exercise were widely used among stroke patients. Integrating safe and effective traditional Chinese medicine and complementary and alternative medicine into conventional therapies is suggested.
November 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29025275/complementary-and-alternative-medicine-use-in-minority-and-medically-underserved-oncology-patients-assessment-and-implications
#6
Desiree Jones, Lorenzo Cohen, Alyssa G Rieber, Diana Urbauer, Bryan Fellman, Michael J Fisch, Arlene Nazario
INTRODUCTION: Complementary and alternative medicine (CAM) use in minority and medically underserved oncology patients is not well documented. We assessed knowledge and utilization of CAM in a sample of these patients receiving treatment at an urban community hospital. METHODS: Patients with cancer were interviewed using an electronic application that depicted specific CAM therapies. Patients were questioned on their knowledge and utilization of therapies, deterrents to use, and interest in using these therapies if they were made available...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29022740/long-term-room-temperature-storage-of-dry-ribonucleic-acid-for-use-in-rna-seq-analysis
#7
Qiyuan Li, Xian Wang, Xiaopan Liu, Qiuyan Liao, Jianbo Sun, Xuheng He, Ting Yang, Jiefang Yin, Jia Jia, Xue Li, Marthe Colotte, Jacques Bonnet
RNA is an essential biological material for research in genomics and translational medicine. As such, its storage for biobanking is an important field of study. Traditionally, long-term storage in the cold (generally freezers or liquid nitrogen) is used to maintain high-quality (in terms of quantity and integrity) RNA. Room temperature (RT) preservation provides an alternative to the cold, which is plagued by serious problems (mainly cost and safety), for RNA long-term storage. In this study, we evaluated the performance of several RT storage procedures, including the RNAshell(®) from Imagene, where the RNA is dried and kept protected from the atmosphere, and the vacuum drying of RNA with additives such as the Imagene stabilization solution and a home-made trehalose solution...
October 12, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29021832/pharmacogenomics-in-the-treatment-of-mood-disorders-strategies-and-opportunities-for-personalized-psychiatry
#8
REVIEW
Azmeraw T Amare, Klaus Oliver Schubert, Bernhard T Baune
Personalized medicine (personalized psychiatry in a specific setting) is a new model towards individualized care, in which knowledge from genomics and other omic pillars (microbiome, epigenomes, proteome, and metabolome) will be combined with clinical data to guide efforts to new drug development and targeted prescription of the existing treatment options. In this review, we summarize pharmacogenomic studies in mood disorders that may lay the foundation towards personalized psychiatry. In addition, we have discussed the possible strategies to integrate data from omic pillars as a future path to personalized psychiatry...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/28987077/remission-of-schizoaffective-disorder-using-homeopathic-medicine-2-case-reports
#9
Diane E Grise, Tara Peyman, Jeffrey Langland
Context • Research on the schizophrenia spectrum is primarily focused on pharmaceutical interventions, although alternative treatments have been gaining increasing popularity in recent years because patients are seeking treatments that are effective and have reduced side effects. A significant body of evidence already exists supporting the effectiveness of homeopathy to treat a wide array of illnesses. Objective • The research team intended to demonstrate the need for using both alternative and conventional treatments to improve clinical outcomes in the treatment of schizoaffective disorder...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28987072/adult-use-of-complementary-and-integrative-approaches-to-improve-athletic-performance
#10
Marion Willard Evans, Harrison Ndetan, Vishaldeep Ka Sekhon, Ronald Williams, Brittney Oliver, Michael Perko, Conrad Woolsey, Karan P Singh
Context • In the United States in 2007, approximately 38% of adults, or 4 in 10, used some form of complementary and alternative medicine (CAM). An area in which little is known is the personal integration of CAM therapies by those individuals seeking to improve athletic performance. Objectives • The study intended to assess the use of integrative care by adult athletes in the United States as well as their satisfaction with it, as reported in the 2012 National Health Interview Survey (NHIS). Design • A secondary analysis of the data from the Adult Alternative Health/Complementary Medicine file of the 2012 NHIS was performed...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28984816/reproducibility-of-differential-renal-function-measurement-using-technetium-99m-ethylenedicysteine-dynamic-renal-scintigraphy-a-french-prospective-multicentre-study
#11
Duc L Nguyen, Claire de Labriolle-Vaylet, Emmanuel Durand, Philippe X Fernandez, François Bonnin, Daniel Deliu, Florent L Besson, Philippe Chaumet-Riffaud
OBJECTIVE: Dynamic renal scintigraphy remains the gold standard for assessing differential renal function (DRF). Recently, technetium-99m-ethylenedicysteine (Tc-EC) was shown to be valuable and had similar quality images as technetium-99m-mercaptoacetyltriglycine (Tc-MAG3). However, its reproducibility has never been confirmed. The aim of this study was to perform the first evaluation of Tc-EC reproducibility for assessing DRF in children who were referred for hydronephrosis or urinary tract dilatation...
October 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28971093/antimicrobial-peptides-in-biomedical-device-manufacturing
#12
REVIEW
Martijn Riool, Anna de Breij, Jan W Drijfhout, Peter H Nibbering, Sebastian A J Zaat
Over the past decades the use of medical devices, such as catheters, artificial heart valves, prosthetic joints, and other implants, has grown significantly. Despite continuous improvements in device design, surgical procedures, and wound care, biomaterial-associated infections (BAI) are still a major problem in modern medicine. Conventional antibiotic treatment often fails due to the low levels of antibiotic at the site of infection. The presence of biofilms on the biomaterial and/or the multidrug-resistant phenotype of the bacteria further impair the efficacy of antibiotic treatment...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28970707/role-of-human-wharton-s-jelly-derived-mesenchymal-stem-cells-wj-mscs-for-rescue-of-d-galactosamine-induced-acute-liver-injury-in-mice
#13
Raghu Ramanathan, Secunda Rupert, Sakthivel Selvaraj, Jeswanth Satyanesan, Rosy Vennila, Surendran Rajagopal
BACKGROUND/AIM: Mesenchymal stem cells (MSCs) are multipotent precursor cells having self-renewal ability making them a candidate for use in regenerative medicine. Acute liver injury results in sudden loss of hepatic function leading to organ failure. Liver transplantation is often required to salvage patients with acute liver failure. Due to shortage of organs, identification of alternate method is the need of the hour. In view of this, an attempt has been made to check the regenerative ability of WJ-MSCs (wharton's jelly derived MSC) in mice models for acute liver injury...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28966755/premenstrual-syndrome-symptomatic-and-diagnosed-prevalence-dualistic-treatment-approach-a-cross-sectional-study-in-ukraine
#14
Edith Meszaros Crow, Emilien Jeannot
BACKGROUND: Diagnosing and treatment of premenstrual syndrome (PMS) still pose a challenge in the routine medical practice which usually focuses on single pharmacological therapy. Recent research suggests that the combination of treatments including complementary alternative medicine (CAM) therapies may be more beneficial. The objective of this study was to assess the percentage of diagnosed and nondiagnosed PMS/premenstrual dysphoric disorder (PMDD) based on the presence of adequate symptoms and to compare population using hormonal or pharmaceutical agents versus CAM therapies...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28963061/simplifying-the-use-of-pharmacogenomics-in-clinical-practice-building-the-genomic-prescribing-system
#15
Keith Danahey, Brittany A Borden, Brian Furner, Patrick Yukman, Sheena Hussain, Donald Saner, Samuel L Volchenboum, Mark J Ratain, Peter H O'Donnell
BACKGROUND: A barrier to the use of genomic information during prescribing is the limited number of software solutions that combine a user-friendly interface with complex medical data. We built and designed an online, secure, electronic custom interface termed the Genomic Prescribing System (GPS). METHODS: Actionable pharmacogenomic (PGx) information was reviewed, collected, and stored in the back-end of GPS to enable creation of customized drug- and variant-specific clinical decision support (CDS) summaries...
September 26, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28959370/integrative-sparse-k-means-with-overlapping-group-lasso-in-genomic-applications-for-disease-subtype-discovery
#16
Zhiguang Huo, George Tseng
Cancer subtypes discovery is the first step to deliver personalized medicine to cancer patients. With the accumulation of massive multi-level omics datasets and established biological knowledge databases, omics data integration with incorporation of rich existing biological knowledge is essential for deciphering a biological mechanism behind the complex diseases. In this manuscript, we propose an integrative sparse K-means (is-K means) approach to discover disease subtypes with the guidance of prior biological knowledge via sparse overlapping group lasso...
June 2017: Annals of Applied Statistics
https://www.readbyqxmd.com/read/28939285/complementary-alternative-and-integrative-medicine-use-is-rising-among-aging-baby-boomers
#17
EDITORIAL
Helen Lavretsky
No abstract text is available yet for this article.
August 30, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28934749/the-situation-of-complementary-and-alternative-medicine-integrative-medicine-in-finland-genuine-research-is-needed
#18
Peter Josef Zimmermann, Pauliina Aarva, Minna Sorsa
No abstract text is available yet for this article.
September 22, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28933919/re-chinese-tcm-renaissance-and-the-global-movement-for-integrative-health-and-medicine-by-weeks-j-altern-complement-med-2017-23-79-81
#19
Arthur Yin Fan, Sarah Faggert
No abstract text is available yet for this article.
September 21, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28928789/the-long-term-course-of-outcomes-for-lumbar-intervertebral-disc-herniation-following-integrated-complementary-and-alternative-medicine-inpatient-treatment-a-prospective-observational-study
#20
Moon-Hwi Kim, Yoon Jae Lee, Joon-Shik Shin, Jinho Lee, Haechan Jeong, Me-Riong Kim, Sam-Min Park, Ung Go, Sung-Moon Kim, Jae-Yeong Kim, Dong-Gyu Hwang, In-Hyuk Ha
A prospective observational study was conducted in 524 lumbar intervertebral disc herniation (LDH) inpatients to report the long-term effects of complementary and alternative medicine (CAM) treatment. Participants received integrative CAM treatment during hospitalization, from June 2012 to May 2013, and long-term outcomes were assessed from July to August 2016. Numerical rating scales (NRSs) of back and leg pain, the Oswestry disability index (ODI), satisfaction, surgery, recurrence, and current care status were investigated...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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