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Integrative medicine, alternative medicine

Nikolas Schürger, Evelyn Klein, Alexander Hapfelmeier, Marion Kiechle, Daniela Paepke
BACKGROUND: Although integrative medicine is gaining increasing attention and is claiming more and more its place in modern health care, it still plays a marginal role in conventional maternity care. The present study aims to examine the patterns of Complementary and Alternative Medicine (CAM) use and the demand for integrative therapies, including CAM, relaxation therapies, nutritional counseling, and psychological assistance, among women in pregnancy and childbed. METHODS: The survey was conducted from April 2017 to July 2017 by means of a pseudo-anonymous 38-item questionnaire at the Department of Gynecology and Obstetrics, Klinikum rechts der Isar, Technical University of Munich...
June 15, 2018: BMC Complementary and Alternative Medicine
Nazar AbdulLateef Jassim, Yasameen Abbas Humadi
PURPOSE OF REVIEW: Biosimilars are of growing importance worldwide, and many leading countries are introducing them in their health care systems and are using them in many fields of medicine owing to their low price tags in comparison with the brands and to their similarities in terms of function and side effects. So we cannot look past them and continue to rely on the innovator drugs since many had proven their efficacies in number of researches and Trials, not to mention the burden that many diseases pose on the budgets of the third world countries making using a lower priced alternatives a much appealing choice for the decision makers...
June 13, 2018: Current Rheumatology Reports
Joao Paulo Zambon, In Kap Ko, Mehran Abolbashari, Jennifer Huling, Cara Clouse, Tae Hyoung Kim, Charesa Smith, Anthony Atala, James J Yoo
Kidney transplantation is currently the only definitive solution for the treatment of end-stage renal disease (ESRD), however transplantation is severely limited by the shortage of available donor kidneys. Recent progress in whole organ engineering based on decellularization/recellularization techniques has enabled pre-clinical in vivo studies using small animal models; however, these in vivo studies have been limited to short-term assessments. We previously developed a decellularization system that effectively removes cellular components from porcine kidneys...
June 5, 2018: Acta Biomaterialia
Brandon Worley, Andrew J Nemechek, Samantha Stoler, Joel L Cohen
BACKGROUND: Alternative therapies are favored by some patients. In skin cancer, this may be to try to avoid surgery out of fear for the procedure and its functional or cosmetic consequences. Frequently, use of these therapies is not curative and can cause harm. Our objective is to detail a case where black salve was used as a natural remedy for an atypical fibroxanthoma and resulted in a severe burn. We highlight the challenges of communicating effective treatment options for those who have strong beliefs concerning natural remedies after a cancer diagnosis...
June 1, 2018: Journal of Drugs in Dermatology: JDD
Gail Van Kanegan, Julie Worley
Complementary alternative and integrative medicine (CAIM) modalities are increasingly sought after by patients with chronic health conditions such as substance use disorders (SUDs). Evidence suggests that CAIM interventions can improve symptoms commonly seen in patients with SUDs, such as stress, anxiety, depression, and pain. Mindfulness-based intervention (MBI), such as meditation, has proven effective for a variety of conditions, including SUDs. Other CAIM strategies, such as manipulative body practices and healing energy medicine techniques, are also showing some evidence of effectiveness...
May 1, 2018: Journal of Psychosocial Nursing and Mental Health Services
Vera Meyer, Sascha Jung
The emergence and spread of pathogenic fungi resistant to currently used antifungal drugs represents a serious challenge for medicine and agriculture. The use of smart antimicrobials, so-called "dirty drugs" which affect multiple cellular targets, is one strategy to prevent resistance. Of special interest is the exploitation of the AFP family of antimicrobial peptides, which include its founding member AFP from Aspergillus giganteus . This latter is a highly potent inhibitor of chitin synthesis and affects plasma membrane integrity in many human and plant pathogenic fungi...
June 2, 2018: Microorganisms
Kathrin Moellenhoff, Holger Dette, Evangelos Kotzagiorgis, Stanislas Volgushev, Olivier Collignon
In drug development, comparability of dissolution profiles of 2 different formulations is usually assessed using the similarity factor f2 . In practice, the drug dissolution profiles are deemed similar if the f2 exceeds 50, which occurs when a 10% maximum difference in the mean percentage of the dissolved drug at each time point between test and reference formulation is obtained. According to the Guideline on the Investigation of Bioequivalence (CPMP/EWP/QWP/1401/98 Rev. 1/ Corr **) use of the f2 is however restricted by a set of validity conditions...
June 3, 2018: Statistics in Medicine
James H Rimmer, Mohanraj Thirumalai, Hui-Ju Young, Dori Pekmezi, Tracy Tracy, Emily Riser, Tapan Mehta
Long-term exercise/rehabilitation is an integral component of the continual care for people with multiple sclerosis (MS). However, access to this care, which includes comprehensive exercise/rehabilitation services to people with MS, remains a significant challenge, especially in rural, low-income areas. Telerehabilitation, or what we refer to as teleexercise, can help fill service gaps for underserved MS populations in this region. This pragmatic, cluster randomized controlled effectiveness trial will compare a 12-week, 20 session complementary and alternative medicine (CAM) intervention composed of neurorehabilitative (functional) exercise, yoga and Pilates delivered at home, using pre-loaded tablets and Interactive Voice Response (IVR) system technology (TeleCAM), to the same intervention delivered in clinic by a therapist (DirectCAM)...
May 30, 2018: Contemporary Clinical Trials
James Whedon, Pamela Snider, Sarah Whedon
No abstract text is available yet for this article.
May 31, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Jasper S Möhler, Wilson Sim, Mark A T Blaskovich, Matthew A Cooper, Zyta M Ziora
Silver was widely used in medicine to treat bacterial infections in the 19th and early 20th century, up until the discovery and development of the first modern antibiotics in the 1940s, which were markedly more effective. Since then, every new antibiotic introduced to the clinic has led to an associated development of drug resistance. Today, the threat of extensive bacterial resistance to antibiotics has reignited interest in alternative strategies to treat infectious diseases, with silver regaining well-deserved renewed attention...
May 27, 2018: Biotechnology Advances
Amita Datta-Mannan, Jeffrey Boyles, Lihua Huang, Zhaoyan Yvonne Jin, Amber Peariso, Anthony T Murphy, Bernice Ellis, Nicole Douglass, Fariba Norouziyan-Cooper, Derrick R Witcher
There is a rapidly growing reinvigoration of the investigation of small proteins, cyclic peptides and mAb derived domains as biotherapies. The drugability of these structures are challenged by fast peripheral clearance properties that can reduce their potential to be realized as medicines. Engineering strategies have been of limited value because mechanistically the half-life benefit is manifested by increasing the molecular weight and/or the hydrodyanimc radius which slows the molecule's renal elimination, but can result in the inherent loss of activity and target accessibility...
May 26, 2018: Biotechnology Journal
Yuetao Liu, Wenqian Xu, GuoHong Wang, Xuemei Qin
ETHNOPHARMACOLOGICAL RELEVANCE: Huangqi Jianzhong Tang (HQJZ), a celebrated traditional Chinese medicine (TCM), is commonly used for treatment of chronic atrophic gastritis (CAG) in China. AIM OF THE STUDY: We aimed to screen out the material basis of HQJZ against CAG. MATERIALS AND METHODS: CAG rat model was constructed by alternant administrations of ammonia solution and sodium deoxycholate, and the hunger disorder method. Body weight, biochemical indexes and histopathological exam were used to evaluate the efficacy of HQJZ...
May 16, 2018: Journal of Ethnopharmacology
K Prudnikova, S E Lightfoot Vidal, S Sarkar, T Yu, R W Yucha, N Ganesh, L S Penn, L Han, C L Schauer, E J Vresilovic, M S Marcolongo
Biomimetic proteoglycans (BPGs) were designed to mimic the three-dimensional (3D) bottlebrush architecture of natural extracellular matrix (ECM) proteoglycans, such as aggrecan. BPGs were synthesized by grafting native chondroitin sulfate bristles onto a synthetic poly(acrylic acid) core to form BPGs at a molecular weight of approximately ∼1.6 MDa. The aggrecan mimics were characterized chemically, physically, and structurally, confirming the 3D bottlebrush architecture as well as a level of water uptake, which is greater than that of the natural proteoglycan, aggrecan...
May 10, 2018: Acta Biomaterialia
Mahdi Amiri, Abbasali Nourian, Maryam Khoshkam, Ali Ramazani
Due to the challenges in the control, prevention, and eradication of parasitic diseases like malaria, there is an urgent need to discover new therapeutic agents. Plant-derived medicines may open new ways in the field of antiplasmodial therapy. This study is aimed to investigate the toxicity and in vivo antiplasmodial activity of apigenin, a dietary flavonoid. Apigenin cytotoxicity was investigated on Huh7 cell line, brine shrimp (Artemia salina) larva, and human red blood cells. In vivo toxicity of apigenin was assessed by metabolomics approaches...
May 11, 2018: Phytotherapy Research: PTR
Emerson M Wickwire, Tilak Verma
Value, like beauty, exists in the eye of the beholder. This article places the value of clinical sleep medicine services in historical context and presents a vision for the value-based sleep of the future. First, the history of value and payment in sleep medicine is reviewed from the early days of the field, to innovative disruption, to the widespread adoption of home sleep apnea testing. Next, the importance of economic perspective is discussed, with emphasis on cost containment and cost-shifting between payers, employers, providers, and patients...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Alireza Houshmand, Phil Donkiewicz, Ralf Smeets, Ole Jung, Mike Barbeck
With the emerging development and improvement of biomaterials, the application of ceramics in restorative medicine has experienced a renaissance. New production processes have reportedly helped to overcome unfavorable biomechanical characteristics of these materials, which lead to a wide application of zirconia as ground material for dental implants. Zirconia-based implants are biocompatible, demonstrate ability to osseointegrate and have a teeth-like color, rendering them to be an ideal replacement for titanium-based implant systems, which represent the current gold standard in implantology...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Erik Børve Rasmussen, Karin Isaksson Rø
BACKGROUND: Medically unexplained symptoms (MUS) are a common yet challenging encounter in primary care. The aim of this study was to explore how general practitioners (GPs) understand and handle MUS. METHODS: Three focus group interviews were conducted with a total of 23 GPs. Participants with varied clinical experience were purposively recruited. The data were analysed thematically, using the concept of framing as an analytical lens. RESULTS: The GPs alternated between a biomedical frame, centred on disease, and a biopsychosocial frame, centred on the sick person...
May 2, 2018: BMC Family Practice
Soo Liang Ooi, Lauren Smith, Sok Cheon Pak
Massage therapy (MT) is the most popular complementary and alternative medicine therapy used by the Australian public. With the growing emphasis by the Australian health authority on evidence-informed healthcare decision-making, there is an increasing demand for massage therapists to move towards the evidence-informed practice (EIP). With MT research gaining significant attention over the last 30 years, clinical evidence exists to support the efficacies of MT on many health conditions, including chronic low back pain...
May 2018: Complementary Therapies in Clinical Practice
Abbas Balouchi, Gholamhossein Mahmoudirad, Marie Hastings-Tolsma, Seyed Afshin Shorofi, Hosien Shahdadi, Abdolghani Abdollahimohammad
OBJECTIVES: The purpose of this study was to systematically review the literature to describe the knowledge, attitude and practice of CAM by nurses. METHODS: Three databases were searched for relevant studies from launch through September of 2017 and included MEDLINE, Scopus and Web of science. RESULTS: The average knowledge of CAM therapies by nurses was 62.2% with attitude about use averaging 65.7%. Close to two-thirds (65.9%) reported use of CAM therapies with patients...
May 2018: Complementary Therapies in Clinical Practice
Maoliang Liao, Haihua Shang, Yazhuo Li, Tian Li, Miao Wang, Yanan Zheng, Wenbin Hou, Changxiao Liu
BACKGROUND: Quality control of traditional Chinese medicines is currently a great concern, due to the correlation between the quality control indicators and clinic effect is often questionable. According to the "multi-components and multi-targets" property of TCMs, a new special quality and bioactivity evaluation system is urgently needed. PURPOSE: Present study adopted an integrated approach to provide new insights relating to uncover quality marker underlying the effects of Alisma orientale (AO) on lipid metabolism...
April 3, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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