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Integrative medicine, alternative medicine

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https://www.readbyqxmd.com/read/28444384/e-science-technologies-in-a-workflow-for-personalized-medicine-using-cancer-screening-as-a-case-study
#1
Ola Spjuth, Andreas Karlsson, Mark Clements, Keith Humphreys, Emma Ivansson, Jim Dowling, Martin Eklund, Alexandra Jauhiainen, Kamila Czene, Henrik Grönberg, Pär Sparén, Fredrik Wiklund, Abbas Cheddad, Þorgerður Pálsdóttir, Mattias Rantalainen, Linda Abrahamsson, Erwin Laure, Jan-Eric Litton, Juni Palmgren
Objective: We provide an e-Science perspective on the workflow from risk factor discovery and classification of disease to evaluation of personalized intervention programs. As case studies, we use personalized prostate and breast cancer screenings. Materials and Methods: We describe an e-Science initiative in Sweden, e-Science for Cancer Prevention and Control (eCPC), which supports biomarker discovery and offers decision support for personalized intervention strategies...
April 21, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28438278/complementary-and-alternative-medicine-cam-among-australian-hospital-based-nurses-knowledge-attitude-personal-and-professional-use-reasons-for-use-cam-referrals-and-socio-demographic-predictors-of-cam-users
#2
Seyed Afshin Shorofi, Paul Arbon
OBJECTIVE: This study was intended to examine CAM among Australian hospital-based nurses, identifying their knowledge, attitude, personal and professional use, reasons for use, CAM referrals, and socio-demographic predictors of CAM users. METHODS AND MATERIALS: Nurses holding a qualification in nursing and working in surgical wards were included using a convenience sampling technique. A self-complete questionnaire was developed to achieve the aims of the study. Descriptive and non-parametric statistics were calculated to describe and analyse data...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28427466/determinants-of-orphan-drugs-prices-in-france-a-regression-analysis
#3
Daria Korchagina, Aurelie Millier, Anne-Lise Vataire, Samuel Aballea, Bruno Falissard, Mondher Toumi
BACKGROUND: The introduction of the orphan drug legislation led to the increase in the number of available orphan drugs, but the access to them is often limited due to the high price. Social preferences regarding funding orphan drugs as well as the criteria taken into consideration while setting the price remain unclear. The study aimed at identifying the determinant of orphan drug prices in France using a regression analysis. METHODS: All drugs with a valid orphan designation at the moment of launch for which the price was available in France were included in the analysis...
April 21, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28417080/applying-a-systems-approach-to-thyroid-physiology-looking-at-the-whole-with-a-mitochondrial-perspective-instead-of-judging-single-tsh-values-or-why-we-should-know-more-about-mitochondria-to-understand-metabolism
#4
REVIEW
Roy Moncayo, Helga Moncayo
Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. In this paper we want to challenge this model of limited application by proposing a construct based on a systems approach departing from two basic considerations. In first place since the majority of cases of thyroid disease develop and appear during life it has to be considered as an acquired condition...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28408699/a-novel-cerium-141-based-flood-field-uniformity-phantom-assessment-of-its-suitability-to-perform-daily-uniformity-test-in-a-clinical-nuclear-medicine-department
#5
Ashish Kumar Jha, Sneha Mithun, Manoj H Chauhan, Nilendu C Purandare, Sneha Shah, Archi Agrawal, Sanjay Kumar Saxena, Ashutosh Dash, Venkatesh Rangarajan
Daily quality control of a gamma camera is of utmost importance to assess the suitability of the camera for clinical use. Aim of our study is to find out the relevance of indigenously developed (141)Ce -flood field phantom in daily quality control of gamma camera. Material & Method: Uniformity tests were performed by using (141)Ce-flood field phantom and commercially available (57)Co -flood field phantom, and results compared. Result: The average percentage integral uniformity obtained by (141)Ce -flood field phantom and (57)Co -flood field phantom were 3...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28403478/non-animal-approaches-for-toxicokinetics-in-risk-evaluations-of-food-chemicals
#6
Ans Punt, Ad A C M Peijnenburg, Ron L A P Hoogenboom, Hans Bouwmeester
The objective of the present work was to review the availability and predictive value of non-animal toxicokinetic approaches and to evaluate their current use in European risk evaluations of food contaminants, additives and food contact materials, as well as pesticides and medicines. Results revealed little use of quantitative animal or human kinetic data in risk evaluations of food chemicals, compared with pesticides and medicines. Risk evaluations of medicines provided sufficient in vivo kinetic data from different species to evaluate the predictive value of animal kinetic data for humans...
April 12, 2017: ALTEX
https://www.readbyqxmd.com/read/28398544/beliefs-about-a-complementary-and-alternative-therapy-based-chronic-pain-management-program-for-a-medicaid-population
#7
Elizabeth Donovan, Megan L Ranney, Emily J Patry, Michelle McKenzie, Janette Baird, Traci C Green
Objective.:  Rhode Island Medicaid offers high emergency department utilizers the opportunity to take part in the Chronic Pain Program, an integrated treatment approach that includes free complementary therapies (massage, chiropractic, and acupuncture). The aim of the current analysis was to understand beliefs about the Rhode Island Chronic Pain Program from the perspective of the patient receiving services, the provider delivering services, and the administrator implementing the program...
April 8, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28396098/how-alternative-payment-models-in-emergency-medicine-can-benefit-physicians-payers-and-patients
#8
Nir J Harish, Harold D Miller, Jesse M Pines, Richard D Zane, Jennifer L Wiler
While there has been considerable effort devoted to developing alternative payment models (APMs) for primary care physicians and for episodes of care beginning with inpatient admissions, there has been relatively little attention by payers to developing APMs for specialty ambulatory care, and no efforts to develop APMs that explicitly focus on emergency care. In order to ensure that emergency care is appropriately integrated and valued in future payment models, emergency physicians (EPs) must engage with the stakeholders within the broader health care system...
March 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28393428/interactive-web-based-format-vs-conventional-brochure-material-for-information-transfer-to-children-and-parents-a-randomized-controlled-trial-regarding-preoperative-information
#9
Gunilla Lööf, Cecilia Liljeberg, Staffan Eksborg, Per-Arne Lönnqvist
BACKGROUND: Information transfer to patients is an integral part of modern medicine. Internet-based alternatives represent a new and attractive way for information transfer. METHODS: The study used a prospective observer-blinded design. Children (3-12 years) and parents were instructed to get further preoperative information either through an interactive web-based platform, the Anaesthesia-Web, or conventional brochure material until day of outpatient surgery. On the day of surgery, children and parents were separately asked six different questions...
April 10, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28390519/integrative-medicine-in-traumatic-brain-injury
#10
REVIEW
David F Drake, Anne M Hudak, William Robbins
Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not presently considered to be a part of conventional medicine. Integrative medicine combines treatment with conventional medical practices and elements of CAM in which there is strong evidence in efficacy and safety. Although there is growing interest in the integrative medical approach in treating the patient population with traumatic brain injury, there is a paucity in high-quality clinical trials supporting its use...
May 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/28369063/tablet-computer-enhanced-training-improves-internal-medicine-exam-performance
#11
Daniel C Baumgart, Ilja Wende, Ulrike Grittner
BACKGROUND: Traditional teaching concepts in medical education do not take full advantage of current information technology. We aimed to objectively determine the impact of Tablet PC enhanced training on learning experience and MKSAP® (medical knowledge self-assessment program) exam performance. METHODS: In this single center, prospective, controlled study final year medical students and medical residents doing an inpatient service rotation were alternatingly assigned to either the active test (Tablet PC with custom multimedia education software package) or traditional education (control) group, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28367097/lyophilized-powder-of-catalpol-and-puerarin-protected-cerebral-vessels-from-ischemia-by-its-anti-apoptosis-on-endothelial-cells
#12
Yang Liu, Qing Tang, Siying Shao, Yi Chen, Weihai Chen, Xiaoyu Xu
Catalpol and puerarin are two monomers of Rehmannia glutinosa and Lobed Kudzuvine Root, which are two herbs commonly used together in ancient prescriptions of traditional Chinese medicine for cerebral ischemia. Our previous study shows that the lyophilized powder of the two monomers improved the outcome of cerebral ischemia excellently in rodents. However, if it protects vessels from ischemia is unknown. The present research studied the protection of lyophilized powder of catalpol and puerarin (CP) on endothelial cells and the relative mechanism in vivo and in vitro...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28364873/broadening-our-perspectives-on-complementary-and-alternative-medicine-for-menopause-a-narrative-review
#13
REVIEW
Dunia Tonob, Melissa K Melby
Complementary and alternative medicine (CAM) is widely used for menopause, although not all women disclose use to their healthcare providers. This narrative review aims to expand providers' understanding of cross-cultural approaches to treating and managing menopause by providing an overarching framework and perspective on CAM treatments. Increased provider understanding and awareness may improve not only provider-patient communication but also effectiveness of treatments. The distinction between illness (what patients suffer) and disease (what physicians treat) highlights the gap between what patients seek and doctors provide, and may help clarify why many women seek CAM at menopause...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28344030/antibacterial-activity-of-medicinal-plants-from-the-physicians-of-myddvai-a-14th-century-welsh-medical-manuscript
#14
Charles Stephen Wagner, Jillian De Gezelle, Maureen Robertson, Keith Robertson, Mickey Wilson, Slavko Komarnytsky
ETHNOPHARMACOLOGICAL RELEVANCE: Antimicrobial drug resistance is a growing threat to global public health. Historical records and herbal texts relating to traditional Celtic medicine indicate an extensive pharmacopeia of plants for treating infections likely caused by microbes. However, a major barrier for successful integration of these remedies into mainstream practice is the current lack of accurate interpretation and scientific validation. MATERIALS AND METHODS: We investigated the flora of the Isle of Arran, Scotland, via in situ targeted screening of 83 out of 138 plants identified in Meddygion Myddvai (a 14th century Welsh manuscript) to treat conditions related to microbial infections, and an additional 18 plants from modern ethnobotanical knowledge on the island (Scottish School of Herbal Medicine)...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28335766/barriers-to-the-conduct-and-application-of-research-in-complementary-and-alternative-medicine-a-systematic-review
#15
REVIEW
Yasamin Veziari, Matthew J Leach, Saravana Kumar
BACKGROUND: The popularity of Complementary and alternative medicine (CAM) has grown considerably over the past few decades. This has been accompanied by increasing public pressure for CAM to be evidence-based. Notwithstanding, the conduct and application of research in CAM faces a number of obstacles. No systematic review has mapped these barriers to date. Therefore, this systematic literature review aimed to explore, identify and map the barriers to the conduct and application of research in CAM...
March 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28331996/use-of-complementary-and-integrative-medicine-among-german-breast-cancer-patients-predictors-and-implications-for-patient-care-within-the-praegnant-study-network
#16
Carlo Fremd, Carolin C Hack, Andreas Schneeweiss, Geraldine Rauch, Diethelm Wallwiener, Sara Yvonne Brucker, Florin-Andrei Taran, Andreas Hartkopf, Friedrich Overkamp, Hans Tesch, Tanja Fehm, Peyman Hadji, Wolfgang Janni, Diana Lüftner, Michael P Lux, Volkmar Müller, Johannes Ettl, Erik Belleville, Christof Sohn, Florian Schuetz, Matthias M Beckmann, Peter A Fasching, Markus Wallwiener
PURPOSE: The present study aims to analyze a cohort of advanced breast cancer patients in Germany to assess their interest in complementary and alternative medicine (CAM) and patient's use of most frequent CAM methods. PATIENTS AND METHODS: Based on the PREGNANT real-time breast cancer registry which is a multicenter study in Germany, questionnaires of 580 patients with advanced breast cancer were evaluated. The implemented questionnaire for CAM asked for general interest in CAM and for patient's use of different CAM methods at present and in the past...
March 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28321921/insights-into-cell-free-therapeutic-approach-role-of-stem-cell-soup-ernatant
#17
REVIEW
Shalini Raik, Ajay Kumar, Shalmoli Bhattacharyya
Current advances in medicine have revolutionized the field of regenerative medicine dramatically with newly evolved therapies for repair or replacement of degenerating or injured tissues. Stem cells can be harvested from different sources for clinical therapeutics which include fetal tissues, umbilical cord blood, embryos and adult tissues. Stem cells can be isolated and differentiated into desired lineages for tissue regeneration and cell replacement therapy. However, several loopholes need to be addressed properly before this can be extended for large scale therapeutic application...
March 21, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28316635/epigenetic-mechanisms-of-integrative-medicine
#18
REVIEW
Riya R Kanherkar, Susan E Stair, Naina Bhatia-Dey, Paul J Mills, Deepak Chopra, Antonei B Csoka
Since time immemorial humans have utilized natural products and therapies for their healing properties. Even now, in the age of genomics and on the cusp of regenerative medicine, the use of complementary and alternative medicine (CAM) approaches represents a popular branch of health care. Furthermore, there is a trend towards a unified medical philosophy referred to as Integrative Medicine (IM) that represents the convergence of CAM and conventional medicine. The IM model not only considers the holistic perspective of the physiological components of the individual, but also includes psychological and mind-body aspects...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28297587/efficiently-specified-ventral-midbrain-dopamine-neurons-from-human-pluripotent-stem-cells-under-xeno-free-conditions-restore-motor-deficits-in-parkinsonian-rodents
#19
Jonathan C Niclis, Carlos W Gantner, Walaa F Alsanie, Stuart J McDougall, Chris R Bye, Andrew G Elefanty, Edouard G Stanley, John M Haynes, Colin W Pouton, Lachlan H Thompson, Clare L Parish
Recent studies have shown evidence for the functional integration of human pluripotent stem cell (hPSC)-derived ventral midbrain dopamine (vmDA) neurons in animal models of Parkinson's disease. Although these cells present a sustainable alternative to fetal mesencephalic grafts, a number of hurdles require attention prior to clinical translation. These include the persistent use of xenogeneic reagents and challenges associated with scalability and storage of differentiated cells. In this study, we describe the first fully defined feeder- and xenogeneic-free protocol for the generation of vmDA neurons from hPSCs and utilize two novel reporter knock-in lines (LMX1A-eGFP and PITX3-eGFP) for in-depth in vitro and in vivo tracking...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28297585/electromechanical-conditioning-of-adult-progenitor-cells-improves-recovery-of-cardiac-function-after-myocardial-infarction
#20
Aida Llucià-Valldeperas, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Benjamin Sanchez, Ramon Bragos, Gordana Vunjak-Novakovic, Antoni Bayes-Genis
Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. Our goals were (a) to study the viability of a tissue-engineered construct with cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs) and (b) to examine the effect of electromechanically stimulated cardiac ATDPCs within a myocardial infarction (MI) model in mice for the first time...
March 2017: Stem Cells Translational Medicine
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