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IL-6 Chemoradiation therapy

Paolo Bossi, Cristiana Bergamini, Rosalba Miceli, Agata Cova, Ester Orlandi, Carlo Resteghini, Laura Locati, Salvatore Alfieri, Martina Imbimbo, Roberta Granata, Luigi Mariani, Nicola Alessandro Iacovelli, Veronica Huber, Anna Cavallo, Lisa Licitra, Licia Rivoltini
PURPOSE: We assessed the presence of salivary cytokines, their modulation during chemoradiation therapy (CTRT), and their association with oral mucositis severity in patients with head and neck cancer (HNC). METHODS AND MATERIALS: The present prospective observational study enrolled 55 patients with locally advanced HNC requiring CTRT. We also studied 10 healthy volunteers and 10 patients with other cancers. The salivary levels of 13 cytokines were analyzed. We constructed a cytokine predictive score of oral mucositis severity...
September 6, 2016: International Journal of Radiation Oncology, Biology, Physics
Jeong Il Yu, Do Hoon Lim, Yong Chan Ahn, Jeeyun Lee, Won Ki Kang, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Seung Tae Kim, Sung Kim, Tae Sung Sohn, Min Gew Choi, Jae Moon Bae, Heerim Nam
PURPOSE: We investigated which subgroups might benefit from adjuvant radiotherapy (RT) and suggested optimal RT targets by analyzing the results of the Adjuvant Chemoradiation Therapy in Stomach Cancer (ARTIST) trial. METHODS: We conducted randomized controlled trial in 458 gastric cancer patients. Patients were randomly assigned to XP (6 cycles of capecitabine and) or XPRT (2 cycles of XP+RT 45Gy/25 fraction with capecitabine+2 cycles of XP) groups after D2 resection...
October 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Shankar Siva, Michael MacManus, Tomas Kron, Nickala Best, Jai Smith, Pavel Lobachevsky, David Ball, Olga Martin
PURPOSE: Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung cancer (NSCLC). We investigated the kinetics of RT induced plasma inflammatory cytokines in these patients in order to identify clinical predictors of toxicity. EXPERIMENTAL DESIGN: In 12 NSCLC patients, RT to 60 Gy (30 fractions over 6 weeks) was delivered; 6 received concurrent chemoradiation (chemoRT) and 6 received RT alone. Blood samples were taken before therapy, at 1 and 24 hours after delivery of the 1st fraction, 4 weeks into RT, and 12 weeks after completion of treatment, for analysis of a panel of 22 plasma cytokines...
2014: PloS One
Marshall S Baker, Nicholas J Zyromski
The 48th annual Pancreas Club meeting was held on May 2 and 3, 2014, at the Westin Lombard in Lombard, IL. Two hundred sixty attendees included pancreatologists from 17 countries. Two hundred eleven abstracts were submitted; from these, a record number (64) oral presentations and 136 posters were selected. Table 1 documents oral abstract titles with institutional affiliation. Full abstracts for all oral presentations and posters are available at the Pancreas Club website, . Representative abstracts from each of the eight sessions are summarized below...
August 2014: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Noriko Tada, Nelson H Tsuno, Kazushige Kawai, Koji Murono, Takako Nirei, Soichiro Ishihara, Eiji Sunami, Joji Kitayama, Toshiaki Watanabe
In the present study, we aimed to characterize the predictive value of cytokines/chemokines in rectal cancer (RC) patients receiving chemoradiation therapy (CRT). Blood samples were obtained pre- and post-CRT from 35 patients with advanced RC, who received neoadjuvant CRT followed by surgery, and the correlation between plasma levels of cytokines/chemokines and the response to CRT was analyzed. The pre-CRT levels of soluble CD40-ligand (sCD40L) and the post-CRT levels of chemokine ligand-5 (CCL-5) were significantly associated with the depth of tumor invasion and with venous invasion...
January 2014: Oncology Reports
Xin Shelley Wang, Loretta A Williams, Sunil Krishnan, Zhongxing Liao, Ping Liu, Li Mao, Qiuling Shi, Gary M Mobley, Jeanie F Woodruff, Charles S Cleeland
Although evidence of inflammation and fatigue has been noted in cancer survivors, whether inflammation is linked to the expression of fatigue and other symptoms arising from concurrent chemoradiation therapy (CXRT) has not been well studied. Patients undergoing CXRT for locally advanced colorectal or esophageal cancer (n=103) reported multiple symptoms weekly via the M. D. Anderson Symptom Inventory (MDASI) from start of therapy. Serum samples were collected weekly to examine changes in inflammatory markers (interleukin (IL)-6, IL-8, IL-10, IL-1 receptor antagonist (IL-1RA), vascular endothelial growth factor (VEGF), and soluble receptor 1 for tumor necrosis factor (sTNF-R1)) via enzyme-linked immunosorbent assay...
July 2012: Brain, Behavior, and Immunity
Xin Shelley Wang, Qiuling Shi, Loretta A Williams, Li Mao, Charles S Cleeland, Ritsuko R Komaki, Gary M Mobley, Zhongxing Liao
Elevations in cancer treatment-induced circulating inflammatory cytokines may be partially responsible for the development of significant symptom burden (e.g., pain, fatigue, distress, disturbed sleep) during concurrent chemoradiation therapy (CXRT). Sixty-two patients undergoing CXRT for locally advanced non-small cell lung cancer (NSCLC) reported symptoms weekly for 15 weeks via the M. D. Anderson Symptom Inventory (MDASI). Serum inflammatory cytokines were assessed weekly during therapy via enzyme-linked immunosorbent assay...
August 2010: Brain, Behavior, and Immunity
Shinichi Okamura, Hitoshi Fujiwara, Kentaro Suchi, Hiroko Okamura, Seiji Umehara, Momoko Todo, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Masayoshi Nakanishi, Daisuke Ichikawa, Shojiro Kikuchi, Kazuma Okamoto, Toshiya Ochiai, Chouhei Sakakura, Yukihito Kokuba, Teruhisa Sonoyama, Eigo Otsuji
Chemoradiation therapy (CRT) for esophageal cancer induces inflammatory responses within tumor tissues. Inflammatory cells infiltrated into the tumor tissues may modulate the CRT responses via inflammation-related molecules such as IL-6 or COX-2. In the present study, we investigated a relationship between IL-6/COX-2 expression and CRT responses for esophageal cancer. A surgical resection following CRT was performed, and the specimens from the patients with cT3/T4 esophageal squamous cell examined for IL-6/COX-2 expression in both residual cancer and stromal cells by immunohistochemical staining...
November 2009: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Annelies Debucquoy, Sarah Roels, Laurence Goethals, Louis Libbrecht, Eric Van Cutsem, Karel Geboes, Freddy Penninckx, André D'Hoore, William H McBride, Karin Haustermans
PURPOSE: To assess the feasibility and efficacy of the COX-2 inhibitor celecoxib in conjunction with preoperative chemoradiation for patients with locally advanced rectal cancer in a double blind randomized phase II study. MATERIALS AND METHODS: Thirty-five patients of the initially planned 80 patients with locally advanced rectal cancer were treated with preoperative radiation (45 Gy; 1.8 Gy/fraction, 5 days/week) combined with 5-fluorouracil (continuous infusion, 225 mg/m(2)/day) and celecoxib (2 x 400 mg/day) or placebo...
November 2009: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Clint Allen, Sonia Duffy, Theodoros Teknos, Mozaffarul Islam, Zhong Chen, Paul S Albert, Gregory Wolf, Carter Van Waes
PURPOSE: Cytokines and growth factors modulated by transcription factor nuclear factor-kappaB and secreted by tumor and stromal cells are detectable in serum of patients with advanced cancers, including head and neck squamous cell carcinomas (SCC). Longitudinal changes in these serum factors could be early biomarkers of treatment response and survival. EXPERIMENTAL DESIGN: Interleukin (IL)-6, IL-8, growth-related oncogene-1 (GRO-1), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) concentrations were determined by Luminex multiplex assay using serum obtained at baseline and every 3 months in a prospective study of 30 patients with locally advanced (stage III/IV) oropharyngeal SCC receiving chemoradiation therapy...
June 1, 2007: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Annelies Debucquoy, Laurence Goethals, Karel Geboes, Sarah Roels, William H Mc Bride, Karin Haustermans
BACKGROUND AND PURPOSE: Some rectal cancers respond well to preoperative neoadjuvant therapy while others are inherently resistant or develop resistance during the treatment. To understand the mechanism underlying these differences, several markers that might be prognostic or predictive of downstaging in response to chemoradiotherapy in patients with rectal cancer were evaluated. MATERIAL AND METHODS: Thirty patients were enrolled in this study. All were treated with preoperative chemoradiation (45Gy in 25 fractions+5-FU)...
August 2006: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Tetsuya Yamamoto, Tsuyoshi Kimura, Eisaku Ueta, Yukihiro Tatemoto, Tokio Osaki
OBJECTIVES: Cytokines produced by tumor cells and tumor-infiltrating lymphocytes (TIL) appear to regulate tumor cell growth and the cytotoxic activity of TIL. The objectives of the present study were to investigate cytokine generation patterns in tumor cells and TIL and to examine the influence of cancer therapy on this cytokine production and the cytotoxic activity of TIL. METHODS: We determined the levels of cytokines produced by tumor cells and TIL in vitro and measured the cytotoxic activity of TIL against Daudi cells in patients with oral squamous cell carcinoma (OSC) before and 1 week after the start of concomitant chemo-radio-immunotherapy...
2003: Oncology
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