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Substance P

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https://www.readbyqxmd.com/read/28225882/a-miracle-cancer-drug-in-the-era-of-social-media-a-survey-of-brazilian-oncologists-opinions-and-experience-with-phosphoethanolamine
#1
Juliana Florinda M Rêgo, Gilberto Lopes, Rachel P Riechelmann, Cinthya Sternberg, Claudio Ferrari, Gustavo Fernandes
INTRODUCTION: Patients who are treating cancer have often used alternative therapies. In the internet era, information can be broadcasted widely, and this happened with phosphoethanolamine in Brazil, where this substance was claimed by the population to be the "cure for cancer." METHOD: This is a cross-sectional study developed by the Brazilian Society of Clinical Oncology (SBOC). An objectively structured questionnaire was sent by e-mail and SMS to active MDs members of the SBOC...
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28225205/greater-endurance-capacity-and-improved-dyspnoea-with-acute-oxygen-supplementation-in-idiopathic-pulmonary-fibrosis-patients-without-resting-hypoxaemia
#2
Leona M Dowman, Christine F McDonald, Steven Bozinovski, Ross Vlahos, Rebecca Gillies, Dodie Pouniotis, Catherine J Hill, Nicole S L Goh, Anne E Holland
BACKGROUND AND OBJECTIVE: Supplemental oxygen is commonly prescribed in patients with idiopathic pulmonary fibrosis (IPF), although its benefits have not been proven. The aims of this study were to investigate the effect of oxygen on oxidative stress, cytokine production, skeletal muscle metabolism and physiological response to exercise in IPF. METHODS: Eleven participants with IPF received either oxygen, at an FiO2 of 0.50, or compressed air for 1 h at rest and during a cycle endurance test at 85% of peak work rate...
February 22, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28224793/a-never-ending-story-of-per-and-polyfluoroalkyl-substances-pfass
#3
Zhanyun Wang, Jamie C DeWitt, Christopher P Higgins, Ian T Cousins
More than 3000 per- and polyfluoroalkyl substances (PFASs) are, or have been, on the global market, yet most research and regulation continues to focus on a limited selection of rather well-known long-chain PFASs, particularly perfluorooctanesulfonate (PFOS), perfluorooctanoic acid (PFOA) and their precursors. Continuing to overlook the vast majority of other PFASs is a major concern for society. We provide recommendations for how to proceed with research and cooperation to tackle the vast number of PFASs on the market and in the environment...
February 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28223844/neuronal-plasticity-of-trigeminal-ganglia-in-mice-following-nerve-injury
#4
Randi Lynds, Chuang Lyu, Gong-Wei Lyu, Xie-Qi Shi, Annika Rosén, Kamal Mustafa, Tie-Jun Sten Shi
BACKGROUND: Nerve injury may induce neuropathic pain. In studying the mechanisms of orofacial neuropathic pain, attention has been paid to the plastic changes that occur in the trigeminal ganglia (TGs) and nucleus in response to an injury of the trigeminal nerve branches. Previous studies have explored the impact of sciatic nerve injury on dorsal root ganglia (DRGs) and it has shown dramatic changes in the expression of multiple biomarkers. In large, the changes in biomarker expression in TGs after trigeminal nerve injury are similar to that in DRGs after sciatic nerve injury...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28223748/topical-application-of-eupatilin-ameliorates-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice
#5
Ji Hyun Lee, Ye Jin Lee, Jun Young Lee, Young Min Park
BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disorder with severe pruritus. Despite advancements in medicine, therapeutic treatments for AD are still limited. Eupatilin (5,7-dihydroxy-30,40,6-trimethoxyflavone) is one of the lipophilic flavonoids from Artemisia umbelliformis Lam. and Artemisia genipi Weber. OBJECTIVE: Although it has been reported to act a role in improving inflammation, its action on AD is uncertain. In this study, we examined the role of eupatilin on AD-like skin lesions in NC/Nga mice...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223733/impact-of-humic-acids-on-the-colonic-microbiome-in-healthy-volunteers
#6
Alexander Swidsinski, Yvonne Dörffel, Vera Loening-Baucke, Christoph Gille, Anne Reißhauer, Onder Göktas, Monika Krüger, Jürgen Neuhaus, Wieland Schrödl
AIM: To test the effects of humic acids on innate microbial communities of the colon. METHODS: We followed the effects of oral supplementation with humic acids (Activomin(®)) on concentrations and composition of colonic microbiome in 14 healthy volunteers for 45 d. 3 × 800 mg Activomin(®) were taken orally for 10 d followed by 3 × 400 mg for 35 d. Colonic microbiota were investigated using multicolor fluorescence in situ hybridization (FISH) of Carnoy fixated and paraffin embedded stool cylinders...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28223128/a-screening-assay-for-the-identification-of-host-cell-requirements-and-antiviral-targets-for-hepatitis-d-virus-infection
#7
Bettina Buchmann, Katinka Döhner, Thomas Schirdewahn, Beate Sodeik, Michael P Manns, Heiner Wedemeyer, Sandra Ciesek, Thomas von Hahn
Hepatitis delta virus (HDV) is a minimalistic satellite virus of hepatitis B virus (HBV). HBV/HDV co-infection, i.e. "hepatitis D", is the most severe form of viral hepatitis. No effective therapy for HDV infection is available partly due to the fact that HDV is a highly host-dependent virus devoid of any potentially drugable enzyme encoded in its small genome. In this study we present a semi-automated method to evaluate HDV infection and replication under the influence of different drugs. We utilized a Huh-7/hNTCP cell culture based system in a 96-well plate format, an automated microscope and image acquisition as well as analysis with the CellProfiler software to quantify the impact of these drugs on HDV infection...
February 18, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28222590/a-novel-tumor-pretargeting-system-based-on-complementary-l-configured-oligonucleotides
#8
Maik Schubert, Ralf Bergmann, Christian Foerster, Wiebke Sihver, Stefan Vonhoff, Sven Klussmann, Lucas Bethge, Martin Walther, Jörn Schlesinger, Jens Pietzsch, Jörg Steinbach, Hans-Juergen Pietzsch
Unnatural mirror image L-configured oligonucleotides (L-ONs) are a convenient substance class for the application as complementary in vivo recognition system between a tumor specific antibody and a smaller radiolabeled effector molecule in pretargeting approaches. The high hybridization velocity and defined melting conditions are excellent preconditions of the L-ON based methodology. Their high metabolic stability and negligible unspecific binding to endogenous targets are superior characteristics in comparison to their D-configured analogs...
February 22, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28221955/synergistic-effect-of-freezing-and-irradiation-on-bonito-fish-sarda-sarda-bloch-1793
#9
Can Okan Altan, Hülya Turan
In this study, bonito fish ( Sarda sarda Bloch, 1793) were irradiated at 3 or 5 kGy, packaged, frozen, and stored at -20 ± 2°C for 12 months. During storage, the microbiological, physical, and chemical changes of the fish flesh were then assessed. Increasing the irradiation dose to 5 kGy provided greater inhibition of mesophilic and psychotropic aerobic bacteria (P < 0.05). Because fewer bacteria were detected in irradiated (3 and 5 kGy) as compared with unirradiated control fish suggests that freezing and irradiation yielded better results when combined...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221859/effects-of-methanolic-pomegranate-peel-extract-on-the-chemical-sensory-textural-and-microbiological-properties-of-gutted-rainbow-trout-oncorhynchus-mykiss-during-frozen-storage
#10
Enayat Berizi, Seyed Shahram Shekarforoush, Saeid Hosseinzadeh
The effects of methanolic pomegranate peel extract (MPPE) on the quality of gutted rainbow trout ( Oncorhynchus mykiss ) were examined periodically during 6 months of storage at -18°C. Fresh samples were dipped (ratio of fish to liquid, 1:2 [wt/vol]) in sterile water or in sterile water containing 1, 2, or 4% (wt/vol) MPPE and packed in low-density polyethylene pouches. The control and treated samples were analyzed monthly for microbiological, chemical, sensory, and textural characteristics. Microbial growth in samples was significantly reduced by MPPE treatment (P < 0...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221854/effects-of-fish-derived-biological-preservatives-on-cold-storage-of-grass-carp-ctenopharyngodon-idellus-fillets
#11
Tingting Li, Yang Jiang, Gaowei Jin, Qiancheng Zhao, Jianrong Li
Two kinds of fish-derived natural antimicrobial substances, protamine and catfish ( Clarias fuscus ) epidermal mucus extract (CEME), were evaluated for their effect on the quality of grass carp fillets. Fillets were atmosphere packaged in cast polypropylene bags and were stored at 4°C in a low-temperature incubator without light. Solutions (0.5%, wt/vol) of CEME and protamine were used for dip pretreatment, respectively. Bacteriological (aerobic plate count, Shewanella putrefaciens , Pseudomonas fluorescens ) and physicochemical (pH, total volatile basic nitrogen, K value, surface color, texture profiles, water distribution) parameters and volatile odor compounds were measured on days 0, 3, 6, 9, 12, and 15...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221062/habituation-of-distress-and-craving-during-treatment-as-predictors-of-change-in-ptsd-symptoms-and-substance-use-severity
#12
Christal L Badour, Julianne C Flanagan, Daniel F Gros, Therese Killeen, Irene Pericot-Valverde, Kristina J Korte, Nicholas P Allan, Sudie E Back
OBJECTIVE: Increasing evidence supports the efficacy of trauma-focused exposure therapy in the treatment of posttraumatic stress disorder (PTSD) and co-occurring substance use disorders. Little is known, however, about the mechanisms of change in treatment for patients with PTSD and co-occurring substance use disorders. The aim of the present study was to examine whether within- and between-session habituation of distress and substance craving during imaginal exposure relates to treatment outcomes among U...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28220746/readiness-to-adopt-a-performance-measurement-system-for-substance-abuse-treatment-findings-from-the-service-quality-measures-initiative
#13
B Myers, P Petersen Williams, K Johnson, R Govender, R Manderscheid, J R Koch
BACKGROUND: A performance measurement system - the Service Quality Measures (SQM) initiative - has been developed to monitor the quality of South Africa (SA)'s substance abuse treatment services. Identifying factors associated with readiness to adopt this system may inform strategies to facilitate its robust implementation. OBJECTIVE: To examine factors associated with readiness to adopt a performance measurement system among SA substance abuse treatment providers...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28219712/the-combination-of-mdpv-and-ethanol-results-in-decreased-cathinone-and-increased-alcohol-levels-study-of-such-pharmacological-interaction
#14
R López-Arnau, M Buenrostro-Jáuregui, P Muñoz-Villegas, J Rodríguez-Morató, A Ciudad-Roberts, L Duart, J Camarasa, R De la Torre, D Pubill, E Escubedo
Methylenedioxypyrovalerone (MDPV) is a new psychostimulant cathinone acting as a selective dopamine transporter blocker. Due to the concomitant consumption of ethanol (EtOH) and new psychoactive substances, it is of interest to explore a possible pharmacological interaction between MDPV and EtOH. In locomotor activity assays, EtOH (1g/kg i.p.) elicited a reduction in the stimulant effect induced by low doses of MDPV (0.1-0.3mg/kg, s.c.) in rats, jointly with a decrease in blood and brain MDPV concentrations...
February 17, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28219706/substance-p-activates-mas-related-g-protein-coupled-receptors-to-induce-itch
#15
Ehsan Azimi, Vemuri B Reddy, Paula Juliana Seadi Pereira, Sebastien Talbot, Clifford J Woolf, Ethan A Lerner
BACKGROUND: Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas-related G protein-coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin-1. OBJECTIVE: Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs...
February 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28219705/substance-p-represents-a-novel-first-line-defense-mechanism-in-the-nose
#16
Olivia Larsson, Lotta Tengroth, Yuan Xu, Rolf Uddman, Susanna Kumlien Georén, Lars-Olaf Cardell
BACKGROUND: Neuropeptides, such as substance P (SP), have long been seen as mediators of widespread, continuous airway inflammation, a process known as neurogenic inflammation. However, this has been difficult to demonstrate clinically, suggesting an alternative role for these signaling molecules. OBJECTIVES: To examine the role of SP in nasal infection, by assessing the release of SP in response to viral stimulation and characterizing the effects of SP on innate immunity, the latter reflected in changes in local Toll-like receptor (TLR) expression...
February 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28219697/effect-of-salvia-miltiorrhiza-root-extract-on-brain-acetylcholinesterase-and-butyrylcholinesterase-activities-their-mrna-levels-and-memory-evaluation-in-rats
#17
Marcin Ozarowski, Przemyslaw L Mikolajczak, Anna Piasecka, Radoslaw Kujawski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Michal Szulc, Ewa Kaminska, Malgorzata Kujawska, Agnieszka Gryszczynska, Piotr Kachlicki, Waldemar Buchwald, Andrzej Klejewski, Agnieszka Seremak-Mrozikiewicz
Salvia miltiorrhiza (Lamiaceae), one of the most important and popular plants of traditional medicine of Asia, is used for the prevention and treatment of cardiovascular diseases and in central nervous system disturbances. The main aim of this study was to assess the influence of subchronic (28-fold) administration of Salvia miltiorrhiza root extract (SE, 200mg/kg, p.o.) on behavioural activity and memory of rats and to evaluate the activities of cholinesterases (AChE and BuChE) and gene expression levels of AChE and BuChE as well as of beta-secretase (BACE1) in the hippocampus and frontal cortex in vivo...
February 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28219102/no-evidence-of-racial-differences-in-endothelial-function-and-exercise-blood-flow-in-young-healthy-males-following-acute-antioxidant-supplementation
#18
Rebecca M Kappus, Kanokwan Bunsawat, Alexander J Rosenberg, Bo Fernhall
This study investigated the effects of acute antioxidant supplementation on endothelial function, exercise blood flow and oxidative stress biomarkers in 9 young African American compared to 10 Caucasian males (25.7±1.2 years). We hypothesized that African American males would have lower exercise blood flow and endothelial responsiveness compared to Caucasian males, and these responses would be improved following antioxidant supplementation. Ultrasonography was used to measure blood flow during handgrip exercise...
February 20, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28217539/analysis-of-plasma-lipid-peroxidation-and-antioxidant-enzymes-status-in-patients-of-oral-leukoplakia-a-case-control-study
#19
Kumar Chandan Srivastava, Deepti Shrivastava
AIMS AND OBJECTIVES: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including oral cancer. Mostly, all oral cancer lesions are preceded by a stage of premalignancy. The present study aims to evaluate lipid peroxidation and antioxidant status in the venous blood of patients with different clinicopathologic stages of leukoplakia. MATERIALS AND METHODS: A case control study was designed with the inclusion of 20 new cases of histopathologically proven leukoplakia of various clinical stages along with an equal number of positive and negative control individuals...
December 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28217258/antioxidant-effects-of-aqueous-extract-of-salep-on-paraquat-induced-rat-liver-injury
#20
Shekoufeh Atashpour, Hossein Kargar Jahromi, Zahra Kargar Jahromi, Sanaz Zarei
AIM: To evaluate the effects of aqueous extract of Salep on Paraquat-mediated liver injury. METHODS: In this experimental study, 56 adult male Wistar rats were divided randomly to 7 groups as control, sham, and 5 experimental groups. In control group, rats did not receive any substance during experiment. In Sham group, rats were given distilled water according to their body weight and in experimental groups, Paraquat alone and with different doses of Salep aqueous extract (40, 80, 160 and 320 mg/kg) was given intraperitoneal daily for 14 d...
February 8, 2017: World Journal of Hepatology
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