keyword
https://read.qxmd.com/read/38521499/graded-fgf-activity-patterns-distinct-cell-types-within-the-apical-sensory-organ-of-the-sea-anemone-nematostella-vectensis
#21
JOURNAL ARTICLE
Keith Z Sabin, Shiyuan Chen, Eric M Hill, Kyle J Weaver, Jacob Yonke, MaryEllen Kirkman, William B Redwine, Anna M L Klompen, Xia Zhao, Fengli Guo, Mary Cathleen McKinney, Jessica L Dewey, Matthew C Gibson
Bilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development of the larval apical sensory organ in the sea anemone Nematostella vectensis...
March 21, 2024: Developmental Biology
https://read.qxmd.com/read/38521349/autorepression-of-yeast-hsp70-co-chaperones-by-intramolecular-interactions-involving-their-j-domains
#22
JOURNAL ARTICLE
Mathieu E Rebeaud, Satyam Tiwari, Bruno Fauvet, Adelaïde Mohr, Paolo De Los Rios, Pierre Goloubinoff
The Hsp70 chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) co-evolved with Hsp70s to trigger ATP-hydrolysis and catalytically upload various substrate polypeptides in need to be structurally modified by the chaperone. Here, we measured the protein disaggregation and refolding activities of the main yeast cytosolic Hsp70, Ssa1, in the presence of its most abundant JDPs, Sis1 and Ydj1, and two swap mutants, in which the J-domains have been interchanged...
March 21, 2024: Cell Stress & Chaperones
https://read.qxmd.com/read/38520894/quantification-of-cd3-foxp3-and-granzyme-b-immunostaining-in-canine-renal-cell-carcinoma
#23
JOURNAL ARTICLE
Ashleigh Cournoyer, Hayley Amerman, Charles-Antoine Assenmacher, Amy Durham, James A Perry, Allison Gedney, Nicholas Keuler, Matthew J Atherton, Jennifer A Lenz
Tumor-infiltrating lymphocyte (TIL) density plays an important role in anti-tumor immunity and is associated with patient outcome in various human and canine malignancies. As a first assessment of the immune landscape of the tumor microenvironment in canine renal cell carcinoma (RCC), we retrospectively analyzed clinical data and quantified CD3, FoxP3, and granzyme B immunostaining in formalin-fixed paraffin-embedded tumor samples from 16 dogs diagnosed with renal cell carcinoma treated with ureteronephrectomy...
March 16, 2024: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/38520833/alisol-b-regulates-ampk-mtor-srebps-via-directly-targeting-vdac1-to-alleviate-hyperlipidemia
#24
JOURNAL ARTICLE
Gai Gao, Jie Zhao, Jing Ding, Shuyan Liu, Yanyan Shen, Changxin Liu, Huifen Ma, Yu Fu, Jiangyan Xu, Yiran Sun, Xiaowei Zhang, Zhenqiang Zhang, Zhishen Xie
BACKGROUND: The occurrence of hyperlipidemia is significantly influenced by lipid synthesis, which is regulated by sterol regulatory element binding proteins (SREBPs), thus the development of drugs that inhibit lipid synthesis has become a popular treatment strategy for hyperlipidemia. Alisol B (ALB), a triterpenoid compound extracted from Alisma, has been reported to ameliorate no-nalcoholic steatohepatitis (NASH) and slow obesity. However, the effect of ALB on hyperlipidemia and mechanism are unclear...
December 25, 2023: Phytomedicine
https://read.qxmd.com/read/38519471/correction-c-myc-driven-glycolysis-polarizes-functional-regulatory-b-cells-that-trigger-pathogenic-inflammatory-responses
#25
Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao, Xiaodong Wang, Wen-Hua Wan, Chun-Xiang Huang, Mahepali Mahabati, Zheng-Yu Liu, Jing-Rui Qu, Xiao-Dan Chen, Dong-Ping Chen, Dong-Ming Kuang, Xue-Hao Wang, Yun Chen
No abstract text is available yet for this article.
March 22, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38519055/molecular-assessment-of-intratumoral-immune-cell-subsets-and-potential-mechanisms-of-resistance-to-odronextamab-a-cd20%C3%A3-cd3-bispecific-antibody-in-patients-with-relapsed-refractory-b-cell-non-hodgkin-lymphoma
#26
JOURNAL ARTICLE
Jurriaan Brouwer-Visser, Nathalie Fiaschi, Raquel P Deering, Kamil J Cygan, Darius Scott, Se Jeong, Lauren Boucher, Namita T Gupta, Suraj Gupta, Christina Adler, Max S Topp, Rajat Bannerji, Johannes Duell, Ranjana H Advani, Dina M Flink, Aafia Chaudhry, Gavin Thurston, Srikanth R Ambati, Vladimir Jankovic
BACKGROUND: Patients with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL) have a significant need for effective treatment options. Odronextamab is an Fc-silenced, human, CD20×CD3 bispecific antibody that targets CD20-expressing cells via T-cell-mediated cytotoxicity independent of T-cell/major histocompatibility complex interaction. Phase I results in patients with R/R B-NHL demonstrated that odronextamab monotherapy could achieve deep and durable responses with a generally manageable safety profile (ELM-1; NCT02290951)...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38518381/platycodin-d-facilitates-antiviral-immunity-through-inhibiting-cytokine-storm-via-targeting-k63-linked-traf6-ubiquitination
#27
JOURNAL ARTICLE
Hui Liu, Lirong Xu, Enhao Lu, Chenchen Tang, Hanxiao Zhang, Yanwu Xu, Yuanyuan Yu, Naomi Ong, Xiao-Dong Yang, Qilong Chen, Yuejuan Zheng
Influenza virus infection is a worldwide challenge that causes heavy burdens on public health. The mortality rate of severe influenza patients is often associated with hyperactive immunological abnormalities characterized by hypercytokinemia. Due to the continuous mutations and the occurrence of drug-resistant influenza virus strains, the development of host-directed immunoregulatory drugs is urgently required. Platycodon grandiflorum is among the top 10 herbs of traditional Chinese medicine used to treat pulmonary diseases...
March 22, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38517354/hijacking-and-rewiring-of-host-circrna-mirna-mrna-competitive-endogenous-rna-cerna-regulatory-networks-by-oncoviruses-during-development-of-viral-cancers
#28
REVIEW
Mohammad Javad Kamali, Mohammad Salehi, Mehrnaz Mostafavi, Reza Morovatshoar, Mitra Akbari, Narges Latifi, Omid Barzegari, Fatemeh Ghadimi, Abdolreza Daraei
A significant portion of human cancers are caused by oncoviruses (12%-25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)-mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context...
March 2024: Reviews in Medical Virology
https://read.qxmd.com/read/38517295/the-role-of-coinhibitory-receptors-in-b-cell-dysregulation-in-sars-cov-2-infected-individuals-with-severe-disease
#29
JOURNAL ARTICLE
Suguru Saito, Najmeh Bozorgmehr, Wendy Sligl, Mohammed Osman, Shokrollah Elahi
Severe SARS-CoV-2 infection is associated with significant immune dysregulation involving different immune cell subsets. In this study, when analyzing critically ill COVID-19 patients versus those with mild disease, we observed a significant reduction in total and memory B cell subsets but an increase in naive B cells. Moreover, B cells from COVID-19 patients displayed impaired effector functions, evidenced by diminished proliferative capacity, reduced cytokine, and Ab production. This functional impairment was accompanied by an increased apoptotic potential upon stimulation in B cells from severely ill COVID-19 patients...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38517294/antibody-suppressor-cxcr5-cd8-t-cells-are-more-potent-regulators-of-humoral-alloimmunity-after-kidney-transplant-in-mice-compared-to-cd4-regulatory-t-cells
#30
JOURNAL ARTICLE
Jing L Han, Jason M Zimmerer, Qiang Zeng, Sachi Chaudhari, Anjali Satoskar, Mahmoud Abdel-Rasoul, Hope Uwase, Christopher K Breuer, Ginny L Bumgardner
Adoptive cell therapy (ACT), especially with CD4+ regulatory T cells (CD4+ Tregs), is an emerging therapeutic strategy to minimize immunosuppression and promote long-term allograft acceptance, although much research remains to realize its potential. In this study, we investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells (CD8+ TAb-supp) in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a murine kidney transplant (KTx) model of Ab-mediated rejection (AMR)...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38517239/effect-of-stratified-dose-of-norepinephrine-on-cellular-immune-response-in-patients-with-septic-shock-and-the-construction-of-a-prognostic-risk-model
#31
JOURNAL ARTICLE
Qiang Wang, Jiefu Tang, Yao Li, Jiafei Lu, Dexing Yang, Chen He, Ting Li, Kai Fu, Rong Liu
OBJECTIVE: To explore the effect of a stratified dose of norepinephrine (NE) on cellular immune response in patients with septic shock, and to construct a prognostic model of septic shock. METHODS: A total of 160 patients with septic shock (B group) and 58 patients with sepsis (A group) were given standard cluster therapy. Patients with septic shock were divided into four groups (B1-B4 groups: 0.01-0.2, 0.2-0.5, 0.5-1.0, and > 1 μg/kg/min) according to the quartile method of the early (72 h) time-weighted average dose of NE and clinical application...
March 14, 2024: Shock
https://read.qxmd.com/read/38514625/aberrant-non-canonical-nf-%C3%AE%C2%BAb-signalling-reprograms-the-epigenome-landscape-to-drive-oncogenic-transcriptomes-in-multiple-myeloma
#32
JOURNAL ARTICLE
Daniel A Ang, Jean-Michel Carter, Kamalakshi Deka, Joel H L Tan, Jianbiao Zhou, Qingfeng Chen, Wee Joo Chng, Nathan Harmston, Yinghui Li
In multiple myeloma, abnormal plasma cells establish oncogenic niches within the bone marrow by engaging the NF-κB pathway to nurture their survival while they accumulate pro-proliferative mutations. Under these conditions, many cases eventually develop genetic abnormalities endowing them with constitutive NF-κB activation. Here, we find that sustained NF-κB/p52 levels resulting from such mutations favours the recruitment of enhancers beyond the normal B-cell repertoire. Furthermore, through targeted disruption of p52, we characterise how such enhancers are complicit in the formation of super-enhancers and the establishment of cis-regulatory interactions with myeloma dependencies during constitutive activation of p52...
March 21, 2024: Nature Communications
https://read.qxmd.com/read/38514209/advances-in-sepsis-biomarkers
#33
JOURNAL ARTICLE
Maximo J Marin, Xander M R van Wijk, Allison B Chambliss
Sepsis, a dysregulated host immune response to an infectious agent, significantly increases morbidity and mortality for hospitalized patients worldwide. This chapter reviews (1) the basic principles of infectious diseases, pathophysiology and current definition of sepsis, (2) established sepsis biomarkers such lactate, procalcitonin and C-reactive protein, (3) novel, newly regulatory-cleared/approved biomarkers, such as assays that evaluate white blood cell properties and immune response molecules, and (4) emerging biomarkers and biomarker panels to highlight future directions and opportunities in the diagnosis and management of sepsis...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38511930/host-derived-protease-promotes-aggregation-of-staphylococcus-aureus-by-cleaving-the-surface-protein-sasg
#34
JOURNAL ARTICLE
Heidi A Crosby, Klara Keim, Jakub M Kwiecinski, Christophe J Langouët-Astrié, Kaori Oshima, Wells B LaRivière, Eric P Schmidt, Alexander R Horswill
Staphylococcus aureus is one of the leading causes of hospital-acquired infections, many of which begin following attachment and accumulation on indwelling medical devices or diseased tissue. These infections are often linked to the establishment of biofilms, but another often overlooked key characteristic allowing S. aureus to establish persistent infection is the formation of planktonic aggregates. Such aggregates are physiologically similar to biofilms and protect pathogens from innate immune clearance and increase antibiotic tolerance...
March 21, 2024: MBio
https://read.qxmd.com/read/38510251/functional-significance-of-dna-methylation-epigenetic-insights-into-sj%C3%A3-gren-s-syndrome
#35
REVIEW
Yanqing Wang, Farooq Riaz, Wei Wang, Jincheng Pu, Yuanyuan Liang, Zhenzhen Wu, Shengnan Pan, Jiamin Song, Lufei Yang, Youwei Zhang, Huihong Wu, Fang Han, Jianping Tang, Xuan Wang
Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms contribute to the pathophysiology of SjS by modulating gene expression and genome stability. DNA methylation, a form of epigenetic modification, is the fundamental mechanism that modifies the expression of various genes by modifying the transcriptional availability of regulatory regions within the genome...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38510132/the-nf-%C3%AE%C2%BAb-nuak2-signaling-axis-regulates-pancreatic-cancer-progression-by-targeting-smad2-3
#36
JOURNAL ARTICLE
Ruobing Wang, Dan Su, Yueze Liu, Hua Huang, Jiangdong Qiu, Zhe Cao, Gang Yang, Hao Chen, Wenhao Luo, Jinxin Tao, Guihu Weng, Taiping Zhang
Nuclear factor kappa B (NF-κB) plays a pivotal role in the development of pancreatic cancer, and its phosphorylation has previously been linked to the regulation of NUAK2. However, the regulatory connection between NF-κB and NUAK2, as well as NUAK2's role in pancreatic cancer, remains unclear. In this study, we observed that inhibiting NUAK2 impeded the proliferation, migration, and invasion of pancreatic cancer cells while triggering apoptosis. NUAK2 overexpression partially resisted apoptosis and reversed the inhibitory effects of the NF-κB inhibitor...
April 19, 2024: IScience
https://read.qxmd.com/read/38509306/rna-binding-proteins-potentially-regulate-the-alternative-splicing-of-cell-cycle-associated-genes-in-proliferative-diabetic-retinopathy
#37
JOURNAL ARTICLE
Ning Yang, Ningzhi Zhang, Guojing Lu, Siyu Zeng, Yiqiao Xing, Lei Du
RNA-binding proteins (RBPs) contribute to the pathogenesis of proliferative diabetic retinopathy (PDR) by regulating gene expression through alternative splicing events (ASEs). However, the RBPs differentially expressed in PDR and the underlying mechanisms remain unclear. Thus, this study aimed to identify the differentially expressed genes in the neovascular membranes (NVM) and retinas of patients with PDR. The public transcriptome dataset GSE102485 was downloaded from the Gene Expression Omnibus database, and samples of PDR and normal retinas were analyzed...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508727/transient-receptor-potential-vanilloid-1-interacts-with-tlr4-cd14-signaling-pathway-in-lipopolysaccharide-mediated-inflammation-in-macrophages
#38
JOURNAL ARTICLE
Julia Chu-Ning Hsu, Hsu-Wen Tseng, Chia-Hui Chen, Tzong-Shyuan Lee
Transient receptor potential vanilloid 1 (TRPV1), a ligand-gated cation channel, is a receptor for vanilloids on sensory neurons and is also activated by capsaicin, heat, protons, arachidonic acid metabolites, and inflammatory mediators on neuronal or non-neuronal cells. However, the role of the TRPV1 receptor in pro-inflammatory cytokine secretion and its potential regulatory mechanisms in lipopolysaccharide (LPS)-induced inflammation has yet to be entirely understood. To investigate the role and regulatory mechanism of the TRPV1 receptor in regulating LPS-induced inflammatory responses, bone marrow-derived macrophages (BMDMs) harvested from wild-type (WT) and TRPV1 deficient (Trpv1-/- ) mice were used as the cell model...
March 21, 2024: Experimental Animals
https://read.qxmd.com/read/38508315/non-transcriptional-irf7-interacts-with-nf-%C3%AE%C2%BAb-to-inhibit-viral-inflammation
#39
JOURNAL ARTICLE
Shumin Fan, Sonam Popli, Sukanya Chakravarty, Ritu Chakravarti, Saurabh Chattopadhyay
Interferon (IFN) regulatory factors (IRF) are key transcription factors in cellular antiviral responses. IRF7, a virus-inducible IRF, expressed primarily in myeloid cells, is required for transcriptional induction of IFNα and antiviral genes. IRF7 is activated by virus-induced phosphorylation in the cytoplasm, leading to its translocation to the nucleus for transcriptional activity. Here, we revealed a non-transcriptional activity of IRF7 contributing to its antiviral functions. IRF7 interacted with the pro-inflammatory transcription factor NF-κB-p65 and inhibited the induction of inflammatory target genes...
March 18, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38507738/in-btk-phosphorylated-y223-in-the-sh3-domain-mirrors-catalytic-activity-but-does-not-influence-biological-function
#40
JOURNAL ARTICLE
Hernando Yesid Estupiñan Velasquez, Thibault Bouderlique, Chenfei He, Anna Berglöf, Andrea Cappelleri, Nicolai Frengen, Rula Zain, Mikael C I Karlsson, Robert Månsson, C I Edvard Smith
Bruton's tyrosine kinase (BTK) is an enzyme needed for B-cell survival and inhibitors have become potent targeted medicines for the treatment of B-cell malignancies. The initial activation event of cytoplasmic protein-tyrosine kinases is the phosphorylation of a conserved regulatory tyrosine in the catalytic domain, which in BTK is represented by tyrosine 551. In addition, the tyrosine 223 (Y223) residue in the SRC homology 3 (SH3) domain has for more than two decades generally been considered necessary for full enzymatic activity...
March 20, 2024: Blood Advances
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