Kyoung Soo Kim, Hyun Mi Choi, Yeon-Ah Lee, In Ah Choi, Sang-Hoon Lee, Seung-Jae Hong, Hyung-In Yang, Myung Chul Yoo
This study was performed to provide evidence, albeit indirectly, as to which matrix metalloproteinases (MMPs), among the gelatinases MMP-2 and MMP-9 and the collagenases MMP-1 and MMP-13, play a more proactive role in the angiogenic process in arthritic joint. Joint fluid was collected from 33 patients with rhuematoid arthritis (RA) and osteoarthritis (OA), and protein (MMPs and vascular endothelial growth factor (VEGF)) levels were measured by ELISA, and the association of MMPs with VEGF was evaluated in joint fluid of patients with RA or OA...
April 2011: Rheumatology International