keyword
https://read.qxmd.com/read/38547331/circulating-factors-in-cancer-cachexia-recent-opportunities-for-translational-research
#1
JOURNAL ARTICLE
Marina de Castro Coêlho, Giovana Parreira de Aquino, Amanda Soares Santos, Marilia Seelaender
PURPOSE OF REVIEW: To discuss the recent discoveries and limitations of the available literature on emerging circulating biomarkers of cancer cachexia. RECENT FINDINGS: Studies on circulating factors in cancer cachexia show promising alternatives for diagnosing the syndrome in a minimally invasive manner in the clinic setting, as well as potential targets for cancer cachexia treatment. Factors secreted by the tumor and the adipose tissue, such as extracellular vesicles and soluble proteins, respectively, have been shown to either directly induce wasting in vitro and in vivo or to be altered in the cachectic phenotype...
March 27, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547234/transcriptome-wide-analysis-of-the-differences-between-mcf7-cells-cultured-in-dmem-or-%C3%AE-mem
#2
JOURNAL ARTICLE
Yang Jiao, Hongbo Zhao, Lin Lu, Xiangyu Zhao, Yanchun Wang, Bingrong Zheng
MCF7 cells have been used as an experimental model for breast cancer for decades. Typically, a culture medium is designed to supply cells with the nutrients essential for their continuous proliferation. Each medium has a specific nutritional composition. Therefore, cells cultured in different media may exhibit differences in their metabolism. However, only a few studies have investigated the effects of media on cells. In this study, we compared the effects of Dulbecco's modified Eagle medium (DMEM) and minimum essential medium alpha modification (αMEM) on MCF7 cells...
2024: PloS One
https://read.qxmd.com/read/38547211/short-term-chemotherapy-related-complications-and-undernutrition-in-children-diagnosed-with-cancer-at-korle-bu-teaching-hospital-accra-ghana-a-prospective-cohort-study
#3
JOURNAL ARTICLE
Nihad Salifu, Catherine I Segbefia, Yakubu Alhassan, Lorna A Renner, Edem M A Tette
Undernutrition in children with cancer is associated with complications during cancer therapy. The study objective was to determine the association between specific anthropometric parameters and short-term chemotherapy-related complications and mortality. This was a hospital-based, prospective cohort study of children, age ≤12 years, with a new cancer diagnosis at the Paediatric Oncology Unit, Korle Bu Teaching Hospital, Ghana. Socio-demographic information, cancer characteristics and anthropometric measurements were obtained at enrolment...
2024: PloS One
https://read.qxmd.com/read/38546913/genetic-variations-related-to-angiotensin-ii-production-and-risk-for-basal-cell-carcinoma
#4
REVIEW
Iphigenia Gintoni, Michael Mastrogeorgiou, Veronica Papakosta, Stavros Vassiliou, Christos Yapijakis
Basal cell carcinoma (BCC) is the most prevalent human neoplasm, with constantly increasing annual incidence. Despite its slow growth, BCC is locally invasive and, if left untreated, can cause severe complications, including metastasis and death. The renin-angiotensin system (RAS) plays a key role in electrolyte balance, atrial pressure, tissue development, homeostasis, and inflammation, but also in cancer development. After binding to its type 1 receptor (AT1R), angiotensin II (ANGII), the system's principal hormonal effector, regulates cancer pathways spanning from the formation of the initial cancer cell to the construction and nutrition of the tumor microenvironment, angiogenesis, proliferation, and metastasis...
March 28, 2024: Biochemical Genetics
https://read.qxmd.com/read/38546900/risk-factors-and-the-nomogram-model-for-malnutrition-in-patients-with-nasopharyngeal-carcinoma
#5
JOURNAL ARTICLE
Pengpeng Wang, Xueling Huang, Yuanhang Liu, Li Xue, Chuanyi Ning, Li Jiang, Jieying Liu
BACKGROUND: For patients with nasopharyngeal carcinoma (NPC), the incidence of malnutrition is quite high, and malnutrition has severe effects on NPC patients. However, there is currently no recognized gold standard or specific nutritional assessment tool available to assess malnutrition in NPC patients. Our objective was to develop and verify a new nomogram model for NPC patients. METHODS: Data were collected from NPC patients. To evaluate risk factors for malnutrition, univariate and multivariate logistic regression analyses were used...
March 28, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38546399/nitrosyl-heme-and-heme-iron-intake-from-processed-meats-and-risk-of-colorectal-cancer-in-the-epic-spain-cohort
#6
JOURNAL ARTICLE
Lucía Rizzolo-Brime, Leila Lujan-Barroso, Andreu Farran-Codina, Ricard Bou, Cristina Lasheras, Pilar Amiano, Amaia Aizpurua, Maria-Jose Sánchez, Esther Molina-Montes, Marcela Guevara, Conchi Moreno-Iribas, Alba Gasque, María Dolores Chirlaque-López, Sandra M Colorado-Yohar, José María Huerta, Raul Zamora-Ros, Antonio Agudo, Paula Jakszyn
BACKGROUND: The International Agency for Research on Cancer classified processed meats (PMs) as "carcinogenic" and red meat as "probably carcinogenic" for humans. The possible relationship between colorectal cancer (CRC) risk and the mechanisms involved in the carcinogenesis of PMs have not been established yet. Nitrosyl-heme and heme iron have been proposed as potential-related compounds. The aim of this study was to determine the association between nitrosyl-heme and heme iron intake and CRC risk among participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain study...
March 28, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38546174/breaking-down-cachexia-a-narrative-review-on-the-prevalence-of-cachexia-in-cancer-patients-and-its-associated-risk-factors
#7
REVIEW
Mahmathi Karuppannan, Fares M S Muthanna, Fazlin Mohd Fauzi
Cachexia is an irreversible condition that involves a significant loss of body weight, muscle mass, and adipose tissue. It is a complex condition that involves a variety of metabolic, hormonal, and immune-related factors, with the precise mechanisms not yet fully understood. In this review, the prevalence of cachexia in different types of cancer as well as the potential risk factors was evaluated from literature retrieved from databases such as ScienceDirect, PubMed and Scopus. Potential risk factors evaluated here include tumor-related factors such as location, and stage of the cancer, as well as patient-related factors such as age, gender, and comorbidities...
2024: Nutrition and Cancer
https://read.qxmd.com/read/38545856/relationship-between-educational-level-and-survival-of-patients-with-cancer-a-multicentre-cohort-study
#8
JOURNAL ARTICLE
Xiao-Yue Liu, Xi Zhang, Guo-Tian Ruan, Xin Zheng, Yue Chen, Xiao-Wei Zhang, Tong Liu, Yi-Zhong Ge, Han-Ping Shi
BACKGROUND: Although socioeconomic factors are important determinants of population mortality, the effect of educational level on the survival of patients with cancer in China is unclear. This study aimed to assess whether educational level is associated with the prognosis of patients with cancer and to explore the mediators of this association. METHODS: This multicentre cohort study included 18,251 patients diagnosed with cancer between May 2013 and December 2018...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38545428/interpretation-services-used-for-non-english-language-speaking-patients-with-head-and-neck-cancer-findings-from-a-tertiary-london-cancer-centre
#9
JOURNAL ARTICLE
Maesaya Chartkul, Florence Cook, Roganie Govender
BACKGROUND: Treatment for head and neck cancer (HNC) can lead to profound changes in swallowing function and nutrition. UK HNC standards recommend informational counselling is provided pre-treatment by the dietitian and speech and language therapist (SLT). Non-english speaking patients treated in English speaking countries have poorer treatment outcomes. UK guidance recommends all patients should have access to interpretation services where required. This audit aimed to investigate the language needs and utilisation of interpretation services for patients with HNC attending pre-treatment clinics...
March 2024: Oral Oncol Rep
https://read.qxmd.com/read/38545312/the-evaluation-of-the-effectiveness-of-a-health-promotion-training-on-breast-cancer-survivors
#10
JOURNAL ARTICLE
Bahar Kefeli Çol, Gülnihal Tufan, Dilek Kiliç
BACKGROUND: Increased early diagnosis and improved treatment options have decreased the mortality rate of breast cancer and increased the survival rate. Healthy lifestyle behaviors are very important in breast cancer survivors as they reduce mortality and morbidity rates, cancer recurrence frequency, and side effects of treatment and improve health. This study was conducted to evaluate the effectiveness of a health promotion training intervention in breast cancer survival. MATERIALS AND METHODS: The study is a quasi-experimental, pre-test-post-test and single-group study...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38544750/editorial-a-new-era-shaping-women-s-metabolic-health-fertility-and-sex-related-cancers
#11
EDITORIAL
Costanza Maria Cristiani, Gustavo Cernera, Marzia Di Donato
No abstract text is available yet for this article.
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38543013/unveiling-the-chemical-composition-bioactive-profile-and-antioxidant-capacity-of-dried-egyptian-jew-s-mallow-stems-as-a-promising-anticancer-agent
#12
JOURNAL ARTICLE
Marwa Rashad Ali, Huda Hassan Ibrahim, Aziza Ali Salah-Eldin
Phytochemicals from waste materials generated by agricultural and industrial processes have become globally significant due to their accessibility and potential effectiveness with few side effects. These compounds have essential implications in both medicine and the economy. Therefore, a quantitative analysis of the phytochemical profile, sugar types, and water-soluble vitamins of dried Corchorus olitorius L."DJMS" extract (dried Jew's mallow stem) was carried out with HPLC. In addition, the chemical composition, TPC, chlorophyll a and b, beta-carotene, and antioxidant effect using DPPH were investigated...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542909/characterization-of-an-aptamer-targeting-neu5gc-as-an-endogenous-pathogenic-factor-derived-from-red-meat
#13
JOURNAL ARTICLE
Yuxi Guo, Honglin Ren, Han Wang, Yiran Xiao, Cong Wang, Mengdi Liu, Fuchun Duan, Haosong Li, Pan Hu, Yansong Li, Zengshan Liu, Shiying Lu
N-glycolylneuraminic acid (Neu5Gc), a sialic acid predominantly found in the non-neurohumoral fluids of hind-mouthed animals, is incapable of synthesizing Neu5Gc due to a deletion in the CMAH exon of the gene encoding human CMP-Neu5Gc hydroxylase. But consumption of animal-derived foods that contain Neu5Gc, such as red meat, can instigate an immune response in humans, as Neu5Gc is recognized as a foreign substance by the human immune system. This recognition leads to the production of anti-Neu5Gc antibodies, subsequently resulting in chronic inflammation...
March 13, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542823/genistein-supplementation-and-bone-health-in-breast-cancer-in-rats
#14
JOURNAL ARTICLE
Dorota Skrajnowska, Wojciech Bielecki, Arkadiusz Szterk, Karol Ofiara, Barbara Bobrowska-Korczak
The aim of our study was to analyse the effect of supplementation with various forms of genistein (nano-, micro-, and macro-) on the mineral status of rat femurs in conditions of DMBA-induced mammary gland neoplasia. Thirty-two 30-day-old Sprague Dawley rats were used in the study. The rats were divided into four experimental groups: a control group (without supplementation) and groups supplemented with nanosized (92 ± 41 nm), microsized (587 ± 83 nm), and macrosized genistein. Micromorphometric and histological examination of the rat femurs were performed, as well as analysis of the weight and mineral composition (17 elements)...
March 21, 2024: Nutrients
https://read.qxmd.com/read/38542816/the-inhibitory-effect-of-early-pregnancy-factor-on-red-meat-neu5gc-mediated-antibody-production-in-cmah-mice
#15
JOURNAL ARTICLE
Cong Wang, Honglin Ren, Han Wang, Haosong Li, Jian Guo, Yiran Xiao, Yuxi Guo, Mengdi Liu, Fuchun Duan, Pan Hu, Yansong Li, Zengshan Liu, Shiying Lu
The meat derived from mammals such as cows, sheep, and pigs is commonly referred to as red meat. Recent studies have shown that consuming red meat can activate the immune system, produce antibodies, and subsequently develop into tumors and cancer. This is due to the presence of a potential carcinogenic compound in red meat called N -ethanol neuraminic acid (Neu5Gc). Neu5Gc is a common sialic monosaccharide in mammals, synthesized from N -acetylneuraminic acid (Neu5Ac) in the body and typically present in most mammals...
March 21, 2024: Nutrients
https://read.qxmd.com/read/38542800/daily-caffeine-consumption-may-increase-the-risk-of-acute-kidney-injury-related-to-platinum-salt-chemotherapy-in-thoracic-cancer-patients-a-translational-study
#16
JOURNAL ARTICLE
Aghiles Hamroun, Antoine Decaestecker, Romain Larrue, Sandy Fellah, David Blum, Cynthia Van der Hauwaert, Arnaud Scherpereel, Alexis Cortot, Rémi Lenain, Mehdi Maanaoui, Nicolas Pottier, Christelle Cauffiez, François Glowacki
Although their efficacy has been well-established in Oncology, the use of platinum salts remains limited due to the occurrence of acute kidney injury (AKI). Caffeine has been suggested as a potential pathophysiological actor of platinum-salt-induced AKI, through its hemodynamic effects. This work aims to study the association between caffeine consumption and the risk of platinum-salt-induced AKI, based on both clinical and experimental data. The clinical study involved a single-center prospective cohort study including all consecutive thoracic cancer patients receiving a first-line platinum-salt (cisplatin or carboplatin) chemotherapy between January 2017 and December 2018...
March 19, 2024: Nutrients
https://read.qxmd.com/read/38542791/nitrosyl-heme-and-heme-iron-intake-from-processed-meats-in-subjects-from-the-epic-spain-cohort
#17
JOURNAL ARTICLE
Lucía Rizzolo-Brime, Andreu Farran-Codina, Ricard Bou, Leila Luján-Barroso, Jose Ramón Quirós, Pilar Amiano, María José Sánchez, Miguel Rodríguez-Barranco, Marcela Guevara, Conchi Moreno-Iribas, Alba Gasque, María-Dolores Chirlaque, Sandra M Colorado-Yohar, José María Huerta Castaño, Antonio Agudo, Paula Jakszyn
BACKGROUND: The consumption of processed meats (PMs) and red meats are linked to the likelihood of developing colorectal cancer. Various theories have been proposed to explain this connection, focusing on nitrosyl-heme and heme iron intake. We hypothesized that differences in nitrosyl-heme and heme iron intakes will be associated with various sociodemographic and lifestyle factors. METHODS: The study included 38,471 healthy volunteers (62% females) from five Spanish regions within the EPIC-Spain cohort...
March 18, 2024: Nutrients
https://read.qxmd.com/read/38542784/ferroptosis-altered-micrornas-expression-in-ht-1080-fibrosarcoma-cells-based-on-small-rna-sequencing-and-bioinformatics-analysis
#18
JOURNAL ARTICLE
Qian Zhang, Qiwen Wang, Haoxuan Ding, Caihong Hu, Jie Feng
Iron is an essential trace element in the human body. However, excess iron is harmful and may cause ferroptosis. The expression and role of microRNAs (miRNAs) in ferroptosis remain largely unknown. A model of ferroptosis induced by ferric ammonium citrate in HT-1080 cells was established in this study. The miRNAs expression profiles of the control and iron groups were obtained using small RNA sequencing and verified using qRT-PCR. A total of 1346 known miRNAs and 80 novel miRNAs were identified, including 12 up-regulated differentially expressed miRNAs (DE-miRNAs) and 16 down-regulated DE-miRNAs...
March 17, 2024: Nutrients
https://read.qxmd.com/read/38542782/functional-and-therapeutic-potential-of-cynara-scolymus-in-health-benefits
#19
REVIEW
Chiara Porro, Tarek Benameur, Antonia Cianciulli, Mirco Vacca, Margherita Chiarini, Maria De Angelis, Maria Antonietta Panaro
Dietary supplements enriched with bioactive compounds represent a promising approach to influence physiological processes and enhance longevity and overall health. Cynara cardunculus var. scolymus serves as a functional food supplement with a high concentration of bioactive compounds, which offers various health-promoting benefits. Several chronic diseases have metabolic, genetic, or inflammatory origins, which are frequently interconnected. Pharmacological treatments, although effective, often result in undesirable side effects...
March 17, 2024: Nutrients
https://read.qxmd.com/read/38542774/betanin-attenuates-epigenetic-mechanisms-and-uv-induced-dna-fragmentation-in-hacat-cells-implications-for-skin-cancer-chemoprevention
#20
JOURNAL ARTICLE
Afshin Zand, Sodbuyan Enkhbilguun, John M Macharia, Krisztina Varajti, Istvan Szabó, Gellért Gerencsér, Boglárka Bernadett Tisza, Bence L Raposa, Zoltán Gyöngyi, Timea Varjas
Dermal photoaging refers to the skin's response to prolonged and excessive ultraviolet (UV) exposure, resulting in inflammation, changes to the tissue, redness, swelling, and discomfort. Betanin is the primary betacyanin in red beetroot ( Beta vulgaris ) and has excellent antioxidant properties. Yet, the specific molecular mechanisms of betanin in HaCaT cells have not been fully clarified. The objective of this study was to investigate the activity of betanin and the underlying mechanisms in HaCaT cells; furthermore, in this study, we explored the protective effect of various concentrations of betanin against UVB irradiation on HaCaT cells...
March 16, 2024: Nutrients
keyword
keyword
39611
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.