Linao Sun, Haoran Yue, Hao Fang, Runze Li, Shicong Li, Jianyao Wang, Pengjie Tu, Fei Meng, Wang Yan, Jinxia Zhang, Elena Bignami, Kyeongman Jeon, Biniam Kidane, Peng Zhang
BACKGROUND: Acute lung injury (ALI) caused by hypobaric hypoxia (HH) is frequently observed in high-altitude areas, and it is one of the leading causes of death in high-altitude-related diseases due to its rapid onset and progression. However, the pathogenesis of HH-related ALI (HHALI) remains unclear, and effective treatment approaches are currently lacking. METHODS: A new mouse model of HHALI developed by our laboratory was used as the study subject (Chinese patent No...
March 29, 2024: Journal of Thoracic Disease