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https://www.readbyqxmd.com/read/29236340/flow-cytometry-a-versatile-technology-for-specific-quantification-and-viability-assessment-of-microorganisms-in-multi-strain-probiotic-products
#1
Camille Chiron, Thomas A Tompkins, Pierre Burguière
AIMS: Classical microbiology techniques are the gold standard for probiotic enumeration. However, these techniques are limited by parameters of time, specificity and incapacity to detect viable but non-culturable (VBNC) microorganisms and non-viable cells. The aim of the study was to evaluate flow cytometry as a novel method for the specific quantification of viable and non-viable probiotics in multi-strain products. METHODS AND RESULTS: Custom polyclonal antibodies were produced against five probiotic strains from different species (Bifidobacterium bifidum R0071, Bifidobacterium longum ssp...
December 13, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29235877/cooperative-pd-cu-catalysis-multicomponent-synthesis-of-tetrasubstituted-imidazolones-from-methyl-%C3%AE-isocyanoacetates-primary-amines-and-aryl-vinyl-iodides
#2
Antonin Clemenceau, Qian Wang, Jieping Zhu
Three-component reaction of methyl α,α-disubstituted α-isocyanoacetates, primary amines, and aryl(vinyl) halides in the presence of Pd(OAc)2 (0.05 equiv) and Cu2O (1.0 equiv) provided 2,3,5,5-tetrasubstituted imidazolones via the formation of three chemical bonds. A copper-mediated migratory insertion of the isocyano group into the N-H bond of the amine followed by lactamization and Pd-catalyzed cross-coupling of the in situ generated amidinyl copper species with aryl(vinyl) halides accounted for the reaction outcome...
December 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/29235696/beyond-hydrofunctionalization-a-well-defined-calcium-compound-catalyzed-mild-and-efficient-carbonyl-cyanosilylation
#3
Sandeep Yadav, Ruchi Dixit, Kumar Vanka, Sakya S Sen
Organocalcium compounds have been reported as efficient catalysts for various transformations, for cases where one of the substrates contained a E-H (E=B, N, Si, P) bond. Here, we look at the possibility of employing an organocalcium compound for a transformation in which none of the precursors has a polar E-H bond. This study demonstrates the utilization of a well-defined amidinatocalcium iodide, [PhC(NiPr)2CaI] (1) for cyanosilylation of a variety of aldehydes and ketones with Me3SiCN under ambient conditions without the need of any co-catalyst...
December 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29234476/syntheses-structures-and-stabilities-of-aliphatic-and-aromatic-fluorous-iodine-i-and-iodine-iii-compounds-the-role-of-iodine-lewis-basicity
#4
Tathagata Mukherjee, Soumik Biswas, Andreas Ehnbom, Subrata K Ghosh, Ibrahim El-Zoghbi, Nattamai Bhuvanesh, Hassan S Bazzi, John A Gladysz
The title molecules are sought in connection with various synthetic applications. The aliphatic fluorous alcohols Rfn CH2OH (Rfn = CF3(CF2) n-1; n = 11, 13, 15) are converted to the triflates Rfn CH2OTf (Tf2O, pyridine; 22-61%) and then to Rfn CH2I (NaI, acetone; 58-69%). Subsequent reactions with NaOCl/HCl give iodine(III) dichlorides Rfn CH2ICl2 (n = 11, 13; 33-81%), which slowly evolve Cl2. The ethereal fluorous alcohols CF3CF2CF2O(CF(CF3)CF2O) x CF(CF3)CH2OH (x = 2-5) are similarly converted to triflates and then to iodides, but efforts to generate the corresponding dichlorides fail...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29232998/regio-isomeric-effects-in-tandem-mass-spectra-of-sulfonium-cations-generated-from-thiacyclane-based-sulfonium-salts-under-soft-ionization-conditions
#5
Vladimir G Zaikin, Anton V Kozlov, Roman S Borisov, Igor Yu Shchapin
The influence of regio-isomerism of even-electron sulfonium ions on tandem electrospray and matrix-assisted laser desorption/ionization mass spectra recorded by using collision-induced dissociation was investigated. The initial organic sulfides belonged to isomeric thiabicyclane series (substituted 7- and 8-thiabicyclo[4.3.0]nonanes, 2- and 3-thiabicyclo[4.4.0]decanes) and phenylthiolanes. To investigate by the abovementioned mass spectrometry methods, the sulfides were preliminary S-alkylated by methyl, ethyl iodides, their deuterated analogs and trialkoxonium tetrafluoroborates to form corresponding sulfonium salts...
January 1, 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29232002/effects-of-microrna-93-on-mouse-cardiac-microvascular-endothelial-cells-injury-and-inflammatory-response-by-mediating-spp1-through-the-nf-%C3%AE-b-pathway
#6
Su-Xia Ma, Zhi-Feng Bai, Wei Wang, Hui-Ying Wu
BACKGROUND: This study aims to investigate the regulative role of microRNA-93 (miR-93) in mouse cardiac microvascular endothelial cells (CMECs) injury and inflammatory response by negatively targeting SPP1 gene via the NF-κB signaling pathway. METHODS: Healthy Balb/c mice were recruited to establish mouse model with myocarditis using CVB3 virus. Mice were grouped into the normal, blank, negative control (NC), miR-93 inhibitor, miR-93 mimic, SPP1 shRNA and miR-93 mimic + SPP1 shRNA groups...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29228274/screening-the-toxcast-phase-1-chemical-library-for-inhibition-of-deiodinase-type-1-activity
#7
Michael W Hornung, Joseph J Korte, Jennifer H Olker, Jeffrey S Denny, Carsten Knutsen, Phillip C Hartig, Mary C Cardon, Sigmund J Degitz
Thyroid hormone (TH) homeostasis is dependent upon coordination of multiple key events including iodide uptake, hormone synthesis, metabolism and elimination, to maintain proper TH signaling. Deiodinase enzymes catalyze iodide release from THs to interconvert THs between active and inactive forms, and are integral to hormone metabolism. The activity of deiodinases has been identified as an important endpoint to include in the context of screening chemicals for thyroid hormone disruption. To begin to address the potential for chemicals to inhibit these enzymes an adenovirus expression system was used to produce human deiodinase type 1 (DIO1) enzyme, established robust assay parameters for non-radioactive determination of iodide release by the Sandell-Kolthoff method, and employed a 96-well plate format for screening chemical libraries...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29227694/pulsed-electric-field-assisted-sensitization-of-multidrug-resistant-candida-albicans-to-antifungal-drugs
#8
Vitalij Novickij, Jurgita Švedienė, Algimantas Paškevičius, Svetlana Markovskaja, Irutė Girkontaitė, Auksė Zinkevičienė, Eglė Lastauskienė, Jurij Novickij
AIM: Determine the influence of pH on the inactivation efficiency of C. albicans in pulsed electric fields (PEF) and evaluate the possibilities for sensitization of a drug-resistant strain to antifungal drugs. MATERIALS & METHODS: The effects of PEF (2.5-25 kVcm-1) with fluconazole, terbinafine and naftifine were analyzed at a pH range of 3.0-9.0. Membrane permeabilization was determined by flow cytometry and propidium iodide. RESULTS: PEF induced higher inactivation of C...
December 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29227038/molecular-design-of-efficient-organic-d-a-%C3%AF-a-dye-featuring-triphenylamine-as-donor-fragment-for-application-in-dye-sensitized-solar-cells
#9
Anders Hagfeldt, Parnian Ferdowsi, Yasemin Saygili, Weiwei Zhang, Tomas Edvinsson, Ladislav Kavan, Javad Mokhtari, Shaik M Zakeeruddin, Michael Grätzel
We designed, synthesized and characterized a novel metal-free organic sensitizer, suitable for the application in dye-sensitized solar cells (DSSCs), both experimentally and theoretically. The structure of the novel donor-acceptor-π-bridge-acceptor (D-A-π-A) dye has triphenylamine (TPA) segment and 4-(Benzo[c][1,2,5] thiadiazol-4-ylethynyl) benzoic acid (BTEBA). The triphenylamine unit is widely used as electron donor for the photosensitizers due to its outstanding characteristics, i.e. the non-planar molecular configuration and excellent electron donating capability while 4-(Benzo[c][1,2,5] thiadiazol-4-ylethynyl) benzoic acid is used as electron acceptor unit...
December 11, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29226063/advances-in-antimicrobial-photodynamic-inactivation-at-the-nanoscale
#10
Nasim Kashef, Ying-Ying Huang, Michael R Hamblin
The alarming worldwide increase in antibiotic resistance amongst microbial pathogens necessitates a search for new antimicrobial techniques, which will not be affected by, or indeed cause resistance themselves. Light-mediated photoinactivation is one such technique that takes advantage of the whole spectrum of light to destroy a broad spectrum of pathogens. Many of these photoinactivation techniques rely on the participation of a diverse range of nanoparticles and nanostructures that have dimensions very similar to the wavelength of light...
August 2017: Nanophotonics
https://www.readbyqxmd.com/read/29225137/valproic-acid-a-histone-deacetylase-inhibitor-induces-apoptosis-in-breast-cancer-stem-cells
#11
Nazlıhan Aztopal, Merve Erkisa, Elif Erturk, Engin Ulukaya, Asuman Hatice Tokullugil, Ferda Ari
Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, epigenetic alterations play a crucial role in the regulation of stemness and also have been implicated in the development of drug resistance. Hence, in the present study, we examined the cytotoxic and apoptotic activity of valproic acid (VPA) as an inhibitor of histone deacetylases (HDACs) against breast CSCs (BCSCs)...
December 7, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29224734/optimization-of-the-quenching-and-extraction-procedures-for-a-metabolomic-analysis-of-lactobacillus-plantarum
#12
Qin Yang, Rui Tao, Bo Yang, Hao Zhang, Yong Q Chen, Haiqin Chen, Wei Chen
This study evaluated the quenching and extraction procedures using different solvents at different temperatures for Lactobacillus plantarum ZS2058. Eight quenching methods that used readily available organic solvents (methanol and ethanol) or cryoprotectants (glycerol and dimethyl sulfoxide) were evaluated quantitatively, and their effects on cell membrane integrity and metabolic inactivation were assessed by propidium iodide and energy charge assays, respectively. The combination of 20% methanol and 0.9% sodium chloride (-4 °C), with the lowest propidium iodide labelling rate of 3...
December 7, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29223891/fallen-leaves-derived-honeycomb-like-porous-carbon-as-a-metal-free-and-low-cost-counter-electrode-for-dye-sensitized-solar-cells-with-excellent-tri-iodide-reduction
#13
Sung Min Cha, Goli Nagaraju, S Chandra Sekhar, L Krishna Bharat, Jae Su Yu
Utilizing carbon-based counter electrodes (CEs) in dye-sensitized solar cells (DSSCs) have received much attention in recent times, owing to their low cost, good electrochemical activity, natural abundance and eco-friendly nature. Herein, we have facilely prepared quince leaves derived porous carbon (QLPC) using fallen quince leaves (QLs) and it was used as a cost-effective CE for the fabrication of DSSCs. By means of alkali treatment and pyrolysis process (at different temperatures of 700, 800 and 900 °C), the QLs powder undergoes chemical activation and carbonization, which results in a honeycomb-like QLPC with abundant micro/mesopores and large surface area...
December 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29223782/the-influence-of-precursors-and-treatment-process-on-the-formation-of-iodo-thms-in-canadian-drinking-water
#14
Anca-Maria Tugulea, Rocio Aranda-Rodriguez, Denis Bérubé, Michèle Giddings, France Lemieux, Joan Hnatiw, Luda Dabeka, François Breton
The National Survey of Disinfection By-Products and Selected Emerging Contaminants investigated the formation of various disinfection by-products and contaminants in 65 water treatment systems (WTSs) across Canada. Results for six iodo-trihalomethanes (iodo-THMs) are reported in this paper. The participating water treatment systems included large, medium and small systems using water sources and treatment processes which were representative of Canadian drinking water. Five water samples (source water, treated water and three water samples along the distribution system) were collected from each treatment system, both under winter and summer conditions...
November 27, 2017: Water Research
https://www.readbyqxmd.com/read/29218012/anti-tumor-effect-of-rhaponticum-uniflorum-ethyl-acetate-extract-by-regulation-of-peroxiredoxin1-and-epithelial-to-mesenchymal-transition-in-oral-cancer
#15
Hui Chen, Chunxiao Wang, Moci Qi, Lihua Ge, Zhenchuan Tian, Jinhua Li, Min Zhang, Min Wang, Linfang Huang, Xiaofei Tang
Objective: To explore whether Rhaponticum uniflorum (R. uniflorum) had anti-tumor effects in oral cancer and investigate the molecular mechanisms involved in these anti-tumor effects. Methods: Chemical compositions of R. uniflorum ethyl acetate (RUEA) extracts were detected by ultra-performance liquid chromatography-Q/time-of-flight mass spectrometry (UPLC-Q/TOF-MS), followed by pharmacology-based network prediction analysis. The effects of RUEA extracts on proliferation, apoptosis, migration, and invasion ability of human oral squamous cell carcinoma (OSCC) cell line SCC15 were evaluated by CCK8 assay, Annexin V- fluorescein isothiocyanate/propidium iodide staining, wound healing assay, and Matrigel invasion assay, respectively...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29215922/aptm-a-thiophene-heterocyclic-compound-inhibits-human-colon-cancer-hct116-cell-proliferation-through-p53-dependent-induction-of-apoptosis
#16
Xiaolin Liao, Jiajun Huang, Wanjun Lin, Ze Long, Ying Xie, Wenzhe Ma
To evaluate the in vitro anticancer activity and to investigate the mechanism of action of a thiophene heterocyclic compound, [3-Amino-5-[(2,6-dimethylphenyl)amino]-4-(phenylsulfonyl)-2-thienyl](4-fluorophenyl)methanone (APTM) against human colon cancer HCT116 cells. Sulforhodamine B assay and colony formation assay for cell proliferation assay; propidium iodide (PI) staining for cell cycle profile analysis; Hoechst staining; annexin V-FITC/PI double staining and Western blotting for apoptosis assay. APTM inhibits the growth of HCT116 cells dose and time dependently...
December 7, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/29215798/electrochemical-synthesis-of-aryl-iodides-by-anodic-iododesilylation
#17
Robert Möckel, Jessica Hille, Erik Winterling, Stephan Weidemüller, Tabea Melanie Faber, Gerhard Hilt
An electrochemical access to iodinated aromatic compounds starting from trimethylsilyl-substituted arenes is presented. By design of experiments, highly efficient and mild conditions were identified for a wide range of substrates. A functional group stability test and the synthesis of an important 3-iodobenzylguanidine radiotracer illustrate the scope of this process.
December 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29215782/the-effect-of-urinary-foley-catheter-substrate-material-on-the-antimicrobial-potential-of-calixerene-based-molecules
#18
A Guildford, C Morris, O Kitt, I Cooper
AIMS: This study was to investigate the antimicrobial activity of a modified calixarene polymer bound to a silicone substrate in the presence of pathogens associated with catheter infections, Escherichia coli and Proteus mirabilis. METHODS AND RESULTS: The molecule and its constituent parts, were studied bound and unbound to silicone substrates to ascertain growth effects. Minimum inhibitory and bactericidal concentrations were determined against E.coli and Pr.mirabilis...
December 7, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29215320/early-effects-of-rhodomyrtone-on-membrane-integrity-in-methicillin-resistant-staphylococcus-aureus
#19
Wipawadee Sianglum, Dennapa Saeloh, Pongsri Tongtawe, Natthakul Wootipoom, Nitaya Indrawattana, Supayang Piyawan Voravuthikunchai
Strong evidence of high potency of rhodomyrtone as a promising antibacterial agent against pathogenic gram-positive bacteria has been clearly demonstrated in our previous work. The aim of this study was to provide insight into early action of rhodomyrtone, an acylphloroglucinol, on membrane damage in multidrug-resistant methicillin-resistant Staphylococcus aureus (MRSA). Early effects of rhodomyrtone on the bacterial membrane integrity were detected in a time-course study. Flow cytometry revealed a reduction in green fluorescent emission and increase in uptake of propidium iodide in rhodomyrtone-treated bacterial cells in a concentration- and time-dependent manner...
December 7, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29211704/histone-deacetylase-hdac-inhibitor-suberoylanilide-hydroxamic-acid-saha-induces-apoptosis-in-prostate-cancer-cell-lines-via-the-akt-foxo3a-signaling-pathway
#20
Xuan-Yan Shi, Wei Ding, Tie-Qiu Li, Yi-Xiong Zhang, Shan-Chao Zhao
BACKGROUND Histone deacetylase (HDAC) inhibitors are emerging as a new class of anti-cancer drugs that promote cancer cell apoptosis, and include suberoylanilide hydroxamic acid (SAHA). The aim of this study was to investigate the mechanism of SAHA-induced apoptosis in human prostate cancer cell lines, DU145 and PC-3. MATERIAL AND METHODS Cell lines, DU145 and PC-3, were studied before and after treatment with SAHA. The effects of SAHA treatment on cell proliferation were studied using the MTT cell proliferation assay...
December 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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