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https://www.readbyqxmd.com/read/29667627/propofol-inhibits-hela-cells-by-impairing-autophagic-flux-via-amp-activated-protein-kinase-ampk-activation-and-endoplasmic-reticulum-stress-regulated-by-calcium
#1
Xi Chen, Kai Li, Guoqing Zhao
BACKGROUND Propofol has antitumor effects against various cancers. However, the mechanism of action of propofol in HeLa human cervical cancer cells has not been elucidated. MATERIAL AND METHODS We treated HeLa human cervical cancer cells with different concentrations of propofol. Cell viability was evaluated with Cell Counting Kit-8 and apoptosis was analyzed by annexin V-fluorescein isothiocyanate and propidium iodide staining and flow cytometry. Autophagosome formation was evaluated based on microtubule-associated protein light chain (LC)3 conversion and light chain 3 puncta formation...
April 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29667067/a-first-in-class-inhibitor-mln4924-pevonedistat-induces-cell-cycle-arrest-senescence-and-apoptosis-in-human-renal-cell-carcinoma-by-suppressing-ube2m-dependent-neddylation-modification
#2
Bo Xu, Yuyou Deng, Ran Bi, Haoran Guo, Chang Shu, Neelam Kumari Shah, Junliang Chang, Guanchen Liu, Yujun Du, Wei Wei, Chunxi Wang
PURPOSE: MLN4924 is a second-generation inhibitor that targets ubiquitin-proteasome system by inhibiting neddylation activation enzyme (NAE), and subsequently blocking the neddylation-dependent activation of Cullin-RING E3 ligases (CRLs), which leads to the accumulation of CRLs substrates and hence, suppressing diverse tumor development. In this study, we investigated the potential application of this first-in-class inhibitor MLN4924 in the treatment of human renal cell carcinoma both in vitro and in vivo...
April 17, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29666872/denitrogenative-palladium-catalyzed-coupling-of-aryl-halides-with-arylhydrazines-under-mild-conditions
#3
Sheng Chang, Lin Lin Dong, Hai Qing Song, Bo Feng
The development of a method for the Pd(ii)-catalyzed denitrogenative coupling of arylhydrazines to give functionalized biaryls in good yield, using aryl bromides or aryl iodides as convenient and inexpensive aryl sources, is reported. High functional group tolerance is demonstrated for electronically distinct arylhydrazines as well as aryl halides. The desired products were isolated in good to excellent yields for 58 examples. Control experiments and mechanism studies revealed that the transformation undergoes a base-promoted Pd-catalyzed process...
April 18, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29665575/role-of-fungal-laccase-in-iodide-oxidation-in-soils
#4
Reiko Nihei, Mizuki Usami, Taro Taguchi, Seigo Amachi
Previously, we hypothesized that microbial laccase oxidizes iodide (I- ) in soils to molecular iodine (I2 ) or hypoiodous acid (HIO), both of which are easily incorporated into natural soil organic matter, and thus plays a role in iodine sorption on soils. In this study, soil iodide oxidase activity was determined by a colorimetric assay to evaluate if laccase is responsible for iodide oxidation in soils. Three types of Japanese soil showed significant iodide oxidase activities (0.751-2.87 mU g soil-1 ) at pH 4...
April 14, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29665550/polyfluorinated-iodine-alkanes-regulated-distinct-breast-cancer-cell-progression-through-binding-with-estrogen-receptor-alpha-or-beta-isoforms
#5
Wenting Song, Qian S Liu, Zhendong Sun, Xiaoxi Yang, Qunfang Zhou, Guibin Jiang
Polyfluorinated iodine alkanes (PFIs) are a kind of emerging chemicals with endocrine disrupting effects. Based on the different binding preferences of PFIs to estrogen receptor alpha and beta isoforms (ERα and β), two representative PFIs, dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were selected to evaluate their effects on the proliferation of two kinds of breast cancer cells with different ERα/β expression levels, MCF-7 and T47D. The cell viability assay showed PFHxDI could cause higher cellular toxicity than did PFHxI in both MCF-7 and T47D...
April 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29665260/silver-assisted-synthesis-of-gold-nanorods-the-relation-between-silver-additive-and-iodide-impurities
#6
Sarah Jessl, Moritz Tebbe, Luca Guerrini, Andreas Fery, Ramon A Alvarez-Puebla, Nicolas Pazos-Perez
Seed-mediated methods employing cetyltrimethylammonium bromide (CTAB) as a surfactant, and silver salts as additives, are the most common synthetic strategies for high-yield productions of quality Au nanorods. However, the mechanism of these reactions is not yet fully understood and, importantly, significant lab-to-lab reproducibility issues still affect these protocols. In this study, the direct correlation between the hidden content of iodide impurities in CTAB reagents, which can drastically differ from different suppliers or batches, and the optimal concentration of silver required to maximize the nanorods yield is demonstrated...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29664649/pd-norbornene-collaborative-catalysis-on-the-divergent-preparation-of-heterocyclic-sulfoximine-frameworks
#7
Hao Zhou, Weihao Chen, Zhiyuan Chen
Pd/Norbornene cocatalyzed tandem C-H activation/annulation reactions of free NH-sulfoximines with aryl iodides to produce diverse polyheterocyclic sulfoximines in highly chemoselective models are reported. The reaction tolerated a broad range of functional groups under external oxidant-free conditions. The preliminary mechanistic studies using density functional theory (DFT) calculations highlighted the key role of a PdIV intermediate.
April 17, 2018: Organic Letters
https://www.readbyqxmd.com/read/29664604/sub-bandgap-turn-on-near-infrared-to-visible-up-conversion-device-enabled-by-organic-inorganic-hybrid-perovskite-photovoltaic-absorber
#8
Hyeonggeun Yu, Yuanhang Cheng, Menglin Li, Sai-Wing Tsang, Franky So
Direct integration of an infrared photodetector with an organic light-emitting diode (OLED) enables low cost, pixel-free infrared imaging. However, the operation voltage of the resulting infrared-to-visible up-conversion is large due to the series device architecture. Here, we report a low voltage near infrared (NIR)-to-visible up-conversion device using formamidinium lead iodide as a NIR absorber integrated with a phosphorescent OLED. Due to the efficient photocarrier injection from the hybrid perovskite layer to the OLED, we observed a sub-bandgap turn-on of the OLED under NIR illumination...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29664297/copper-catalyzed-synthesis-of-multisubstituted-indoles-through-tandem-ullmann-type-c-n-formation-and-cross-dehydrogenative-coupling-reactions
#9
Yue Li, Jinsong Peng, Xin Chen, Baichuan Mo, Xue Li, Peng Sun, Chunxia Chen
Multisubstituted indoles were synthesized via a one-pot tandem copper-catalyzed Ullmann-type C-N bond formation/intramolecular cross-dehydrogenative coupling process at 130 ℃ in DMSO. The methodology allows practical and modular assembly of indoles in good to excellent yields from readily available aryl iodides and enamines.
April 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29663808/synthesis-of-2-substituted-quinolines-from-2-aminostyryl-ketones-using-iodide-as-a-catalyst
#10
So Young Lee, Jiye Jeon, Cheol-Hong Cheon
A new protocol for the synthesis of 2-substituted quinolines from 2-aminostyryl ketones has been developed using iodide as a nucleophilic catalyst. Conjugate addition of iodide to 2-aminostyryl ketones yielded the corresponding β-iodoketones, which could have a conformation where the amino and carbonyl groups are proximal through free rotation about the Cα-Cβ single bond. Subsequent condensation between the amino and carbonyl groups followed by elimination of hydrogen iodide provided the corresponding quinolines, with regeneration of the iodide catalyst...
April 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29663742/degenerative-effect-of-ankaferd-blood-stopper%C3%A2-on-mice-peripheral-sensory-neurons-in-vitro
#11
Ramazan Üstün, Elif Kaval Oğuz
Ankaferd Blood Stopper® (ABS) is a licensed medicinal herbal extract that ensures effective hemostasis on external, internal, postoperative and dental bleeds. Dorsal root ganglia (DRG) harbor cell bodies of peripheral sensory neurons. DRG neurons receive peripheral information and regularly send projections to nuclei in the brainstem and the spinal cord. These neurons play critical roles in neural development. Neuronal dysfunctions were reported due to ABS use in surgical interventions. The purpose of this experiment was to investigate the degenerative effects of the ABS on mice DRG cells <I>in vitro</I>...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29662477/new-genes-involved-in-mild-stress-response-identified-by-transposon-mutagenesis-in-lactobacillus-paracasei
#12
Aurore Palud, Hélène Scornec, Jean-François Cavin, Hélène Licandro
Lactic acid bacteria (LAB) are associated with various plant, animal, and human niches and are also present in many fermented foods and beverages. Thus, they are subjected to several stress conditions and have developed advanced response mechanisms to resist, adapt, and grow. This work aimed to identify the genes involved in some stress adaptation mechanisms in LAB. For this purpose, global reverse genetics was applied by screening a library of 1287 Lactobacillus paracasei transposon mutants for mild monofactorial stresses...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29660155/thread-paper-and-paper-based-microfluidic-devices-for-glucose-assays-employing-artificial-neural-networks
#13
Wilson Lee, Ariana Gonzalez, Paolo Arguelles, Ricardo Guevara, Maria Jose Gonzalez-Guerrero, Frank A Gomez
This paper describes the fabrication of and data collection from two microfluidic devices: a microfluidic thread/paper based analytical device (μTPAD) and 3D microfluidic paper-based analytical device (μPAD). Flowing solutions of glucose oxidase (GOx), horseradish peroxidase (HRP), and potassium iodide (KI), through each device, on contact with glucose, generated a calibration curve for each platform. The resultant yellow-brown color from the reaction indicates oxidation of iodide to iodine. The devices were dried, scanned, and analyzed yielding a correlation between yellow intensity and glucose concentration...
April 16, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29658695/pdag-bimetallic-nano-alloy-decorated-graphene-a-nanohybrid-with-unprecedented-electrocatalytic-catalytic-and-sensing-activity
#14
Sajad Ahmad Bhat, Nusrat Rashid, Mudasir Ahmad Rather, Sarwar Ahmad Pandit, Ghulam Mohammad Rather, Pravin P Ingole, Mohsin Ahmad Bhat
The recent reports about the promising and tuneable electrocatalytic activity and stability of nanoalloys have stimulated an intense research activity towards the design and synthesis of homogenously alloyed novel bimetallic nano-electrocatalysts. We, herein present a simple one-pot facile wet-chemical approach for the deposition of high quality bimetallic palladium-silver (PdAg) homogenous nanoalloy crystals on reduced graphene oxide (Gr) sheets. Morphological, structural and chemical characterization of the so crafted nanohybrids establishes a homogeneous distribution of 1:1 PdAg nanoalloy crystals supported over reduced graphene oxide (PdAg-Gr)...
April 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29658611/effects-of-nicotine-on-the-metabolism-and-gene-expression-profile-of-sprague%C3%A2-dawley-rat-primary-osteoblasts
#15
Dan Liang, Ke-Jing Wang, Zhi-Qun Tang, Run-He Liu, Fulei Zeng, Miao-Ying Cheng, Qi-Si Lian, Hong-Kun Wu
Smoking is a risk factor associated with bone and oral diseases, particularly periodontitis. Nicotine, the major toxic component of tobacco, is able to affect the quality and quantity of bone. Osteoblasts serve an important role in bone formation. Thus far, the effects of nicotine on metabolism‑associated gene and protein expression in osteoblasts have been controversial and the mechanisms remain unclear. The present study assessed alterations in osteogenic activity by performing a Cell Counting kit‑8 assay to investigate proliferation, Annexin V‑fluorescein isothiocyanate/propidium iodide staining to investigate apoptosis, alizarin red staining to investigate the formation of mineralized nodules, reverse transcription‑quantitative polymerase chain reaction and western blotting to investigate the mRNA and protein levels of collagen I, alkaline phosphatase, bone osteocalcin, bone sialoprotein and osteopontin; and mRNA microarray expression analysis, Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analysis to investigate the whole genome expression profile of Sprague‑Dawley (SD) rat primary osteoblasts following treatment with different concentrations of nicotine...
April 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29658584/mir%C3%A2-145%C3%A2-5p-reduces-proliferation-and-migration-of-hepatocellular-carcinoma-by-targeting-klf5
#16
Hao Liang, Huiping Sun, Jinfeng Yang, Chun Yi
MicroRNAs (miRs) are important in hepatocellular carcinoma (HCC) progression. miR‑145‑5p acts as a tumor suppressor in certain malignancies, however, its role in HCC remains unclear. The present study aimed to perform a functional analysis of miR‑145‑5p in HCC in order to elucidate its role in the pathogenesis of HCC. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was performed to analyze tissue and cellular expression of miR‑145‑5p in HCC. Following miRNA mimics transfection, cell viability, apoptosis and cells migration were determined by Cell Counting kit‑8, Annexin V‑FITC/propidium iodide staining and Transwell analyses...
April 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29658293/corrigendum
#17
(no author information available yet)
Corrigendum to ICRP Publication 128: Radiation dose to patients from radiopharmaceuticals: a compendium of current information related to frequently used substances. [Ann. ICRP 44(2S), 2015]. DOI: 10.1177/0146645314558019 . The following error has been identified in Table C.109, p. 280: The value of the absorbed dose per unit activity administered to the urinary bladder wall for the 1-year-old child after oral administration of 131 I-iodide should be 1.3E+00 mGy MBq-1 , not 1.3E-01 as was originally stated...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29655615/locked-nucleic-acid-anti-let-7a-induces-apoptosis-and-necrosis-in-macrophages-infected-with-leishmania-major
#18
Nooshin Hashemi, Mohammadreza Sharifi, Mohsen Masjedi, Sepideh Tolouei, Mitra Hashemi, Nahid Mortazavidehkordi, Mohammad Ali Mohaghegh, Cyrus Hashemi, Seyed Hossein Hejazi
BACKGROUND: Protozoan parasites of the genus Leishmania are etiologic agents which are intracellular pathogens of vertebrates and replicate inside infected macrophages. Leishmania have developed complex strategies to reverse host immune responses in favor of it. One of the major species causing cutaneous involvements is Leishmania major. MicroRNAs (miRNA) are non-coding small RNAs encoding 22-nucleotide (nt) long RNAs. miRNAs affect diverse biological processes, including cell cycle, proliferation, differentiation, growth and development, metabolism, aging, apoptosis, gene expression and immune regulation...
April 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29652833/a-lipophilic-ir-780-dye-encapsulated-zwitterionic-polymer-lipid-micellar-nanoparticle-for-enhanced-photothermal-therapy-and-nir-based-fluorescence-imaging-in-a-cervical-tumor-mouse-model
#19
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29651964/poly-l-arginine-enhancing-cytotoxicity-and-cellular-uptake-of-doxorubicin-and-necrotic-cell-death
#20
Bahareh Movafegh, Razieh Jalal, Zobeideh Mohammadi
OBJECTIVE: Cell resistance to doxorubicin and its toxicity to healthy tissue reduce its efficiency. The use of cell penetrating peptides as drug delivery system along with doxorubicin is a strategy to reduce its side effects. In this study, the influence of poly-L-arginine on doxorubicin cytotoxicity, its cellular uptake and doxorubicin-induced apoptosis on human prostate cancer DU145 cells are assessed. METHODS: The cytotoxicity of doxorubicin and poly-L-arginine, alone and in combination, in DU145 cells was evaluated at different exposure times using MTT assay...
April 11, 2018: Anti-cancer Agents in Medicinal Chemistry
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