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https://www.readbyqxmd.com/read/28231545/aqueous-extract-of-cortex-dictamni-protects-h9c2-cardiomyocytes-from-hypoxia-reoxygenation-induced-oxidative-stress-and-apoptosis-by-pi3k-akt-signaling-pathway
#1
Lin Li, Yunfeng Zhou, Yanlin Li, Lili Wang, Lan Sun, Lidong Zhou, Hiderori Arai, Yun Qi, Yang Xu
Ischemia-reperfusion injury is the major manifestation of ischemic heart disease, which facilitates cardiac arrhythmias, heart failure and death. Oxidative stress and apoptosis have been involved in the pathogenesis of myocardial ischemia-reperfusion injury. Modern pharmacological studies have indicated that the extracts and active compounds of Cortex Dictamni exhibit antioxidative and cardiovascular protective activities. This study was designed to investigate the protective effect of aqueous extract of Cortex Dictamni (CDAE) on regulating hypoxia/reoxygenation (H/R)-induced cardiomyocytes oxidative stress and apoptosis...
February 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28231482/fourier-transform-infrared-and-raman-spectroscopy-in-the-study-of-phase-transitions-in-dipyrazolium-iodide-triiodide-experimental-and-theoretical-analysis
#2
M Węcławik, J Baran, P Durlak, Ł Marciniak, A Piecha-Bisiorek, R Jakubas
The paper presents the Infrared and Raman spectra of the powdered [C3N2H5(+)]2[I(-)∙I3(-)] crystal at the temperature intervals of 11-270K, covering two low-temperature phase transitions: discontinuous at 182/188K (cooling/heating) and continuous at 254K. The research shows that the vibrational states of the pyrazolium cations change significantly during discontinuous phase transition (III→II), while the continuous nature of successive structural transformation is more subtle and displays an insignificant change in the temperature coefficient of numerous vibrations during the II→I PT at 254K...
February 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28231432/dismantling-the-red-wall-of-colloidal-perovskites-highly-luminescent-formamidinium-and-formamidinium-cesium-lead-iodide-nanocrystals
#3
Loredana Protesescu, Sergii Yakunin, Sudhir Kumar, Janine Bär, Federica Bertolotti, Norberto Masciocchi, Antonietta Guagliardi, Matthias Grotevent, Ivan Shorubalko, Maryna I Bodnarchuk, Chih-Jen Shih, Maksym V Kovalenko
Colloidal nanocrystals (NCs) of APbX3-type lead halide perovskites [A=Cs+, CH3NH3+ (methylammonium or MA+) or CH(NH2)2+ (formamidinium or FA+); X=Cl-, Br-, I-] have recently emerged as highly versatile photonic sources for applications ranging from simple photoluminescence down-conversion (e.g., for display backlighting) to light emitting diodes. From the perspective of spectral coverage, a formidable challenge facing the use of these materials is how to obtain stable emissions in the red and infrared spectral regions covered by the iodide-based compositions...
February 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28229139/pti2-dach-the-iodido-analogue-of-oxaliplatin-as-a-candidate-for-colorectal-cancer-treatment-chemical-and-biological-features
#4
D Cirri, S Pillozzi, C Gabbiani, J Tricomi, G Bartoli, M Stefanini, E Michelucci, A Arcangeli, L Messori, T Marzo
Colorectal cancer (CRC) is a global health problem being the fourth most common cause of death due to cancer worldwide. Oxaliplatin plays a key role in current CRC treatment but shows serious drawbacks, such as a high systemic toxicity and the frequent insurgence of Pt resistance. In search of novel and more efficacious Pt-based drugs for CRC treatment, we synthesized and characterised PtI2(DACH), an oxaliplatin analogue. PtI2(DACH) was obtained through the replacement of bidentate oxalate with two iodides...
February 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28228636/progressive-ischemic-stroke-due-to-thyroid-storm-associated-cerebral-venous-thrombosis
#5
Natsumi Tanabe, Eiji Hiraoka, Masataka Hoshino, Gautam A Deshpande, Kana Sawada, Yasuhiro Norisue, Jumpei Tsukuda, Toshihiko Suzuki
BACKGROUND Cerebral venous thrombosis (CVT) is a rare but fatal complication of hyperthyroidism that is induced by the hypercoagulable state of thyrotoxicosis. Although it is frequently difficult to diagnose CVT promptly, it is important to consider it in the differential diagnosis when a hyperthyroid patient presents with atypical neurologic symptoms. CASE REPORT A 49-year-old Japanese female with unremarkable medical history came in with thyroid storm and multiple progressive ischemic stroke identified at another hospital...
February 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28228086/clinical-trials-with-oncolytic-measles-virus-current-status-and-future-prospects
#6
Pavlos Msaouel, Mateusz Opyrchal, Angela Dispenzieri, Kah Whye Peng, Mark J Federspiel, Stephen J Russell, Evanthia Galanis
Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives genetically engineered to expressed the human carcinoembryonic antigen (MV-CEA virus) or the human sodium iodide symporter (MV-NIS virus) and are currently being tested in clinical trials against ovarian cancer, glioblastoma multiforme, multiple myeloma, mesothelioma, head and neck cancer, breast cancer and malignant peripheral nerve sheath tumors...
February 22, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28226210/real-time-nanoscale-open-circuit-voltage-dynamics-of-perovskite-solar-cells
#7
Joseph L Garrett, Elizabeth M Tennyson, Miao Hu, Jinsong Huang, Jeremy N Munday, Marina S Leite
Hybrid organic-inorganic perovskites based on methylammonium lead iodide (MAPbI3) are an emerging material with great potential for high-performance and low-cost photovoltaics. However, for perovskites to become a competitive and reliable solar cell technology, their instability and spatial variation must be understood and controlled. While the macroscopic characterization of the devices as a function of time is very informative, a nanoscale identification of their real-time local optoelectronic response is still missing...
February 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28225629/synthesis-of-fluorenones-from-benzaldehydes-and-aryl-iodides-dual-c-h-functionalizations-using-a-transient-directing-group
#8
Xiao-Yang Chen, Seyma Ozturk, Erik J Sorensen
The first synthesis of substituted fluorenones directly from benzaldehydes and aryl iodides via a Pd(II)-catalyzed C(sp(2))-H functionalization cascade is reported. Featuring anthranilic acid as an inexpensive transient directing group, the process is compatible with a variety of benzaldehydes and aryl iodides. A three-step synthesis of the antiviral drug Tilorone was completed in an excellent overall yield (40%), demonstrating the utility of this method.
February 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28225143/spatially-resolved-studies-of-the-phases-and-morphology-of-methylammonium-and-formamidinium-lead-tri-halide-perovskites
#9
K Galkowski, A A Mitioglu, A Surrente, Z Yang, D K Maude, P Kossacki, G E Eperon, J T-W Wang, H J Snaith, P Plochocka, R J Nicholas
The family of organic-inorganic tri-halide perovskites including MA (MethylAmmonium)PbI3, MAPbI3-xClx, FA (FormAmidinium)PbI3 and FAPbBr3 are having a tremendous impact on the field of photovoltaic cells due to the combination of their ease of deposition and high energy conversion efficiencies. Device performance, however, is known to be still significantly affected by the presence of inhomogeneities. Here we report on a study of temperature dependent micro-photoluminescence which shows a strong spatial inhomogeneity related to the presence of microcrystalline grains, which can be both bright and dark...
February 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28225083/antitumorigenic-effect-of-atmospheric-pressure-dielectric-barrier-discharge-on-human-colorectal-cancer-cells-via-regulation-of-sp1-transcription-factor
#10
Duksun Han, Jin Hyoung Cho, Ra Ham Lee, Woong Bang, Kyungho Park, Minseok S Kim, Jung-Hyun Shim, Jung-Il Chae, Se Youn Moon
Human colorectal cancer cell lines (HT29 and HCT116) were exposed to dielectric barrier discharge (DBD) plasma at atmospheric pressure to investigate the anticancer capacity of the plasma. The dose- and time-dependent effects of DBDP on cell viability, regulation of transcription factor Sp1, cell-cycle analysis, and colony formation were investigated by means of MTS assay, DAPI staining, propidium iodide staining, annexin V-FITC staining, Western blot analysis, RT-PCR analysis, fluorescence microscopy, and anchorage-independent cell transformation assay...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28222424/1%C3%AE-25-oh-2d3-sensitive-cytosolic-ph-regulation-and-glycolytic-flux-in-human-endometrial-ishikawa-cells
#11
Ni Zeng, Yuetao Zhou, Shaqiu Zhang, Yogesh Singh, Bing Shi, Madhuri S Salker, Florian Lang
BACKGROUND/AIMS: Tumor cell proliferation is modified by 1,25-Dihydroxy-Vitamin D3 (1,25(OH)2D3), a steroid hormone predominantly known for its role in calcium and phosphorus metabolism. Key properties of tumor cells include enhanced glycolytic flux with excessive consumption of glucose and formation of lactate. As glycolysis is highly sensitive to cytosolic pH, maintenance of glycolysis requires export of H+ ions and lactate, which is in part accomplished by Na+/H+ exchangers, such as NHE1 and monocarboxylate transporters, such as MCT4...
February 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28221765/design-of-macroscopically-ordered-liquid-crystalline-hydrogel-columns-knitted-with-nanosilver-for-topical-applications
#12
Sudha Janardhanan Devaki, Reshma Lali Raveendran, Nishanth Kumar Sasidharan
Design of liquid crystalline hydrogels knitted with silver nanoparticles in macroscopic ordering are becoming subject of research interest due to their promising multifunctional applications in biomedical and opto-electronic applications. The present work describes the development of liquid crystalline Schiff-based hydrogel decorated with silver nanoparticles and demonstration of its antifungal applications. Schiff base was prepared from polyglucanaldehyde and chitosan and the former was prepared by the oxidation of amylose (polyglucopyranose) isolated from abundantly available unutilised jackfruit seed starch...
February 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28220909/effects-of-meso-2-3-dimercaptosuccinic-acid-potassium-iodide-and-chlorophyll-on-lead-accumulation-in-male-mice
#13
Ying Xie, Guifeng Zhou
OBJECTIVES: Lead (Pb) pollution is a serious public health problem all over the world, it especially plays severe damage role in children's health. Apart from reducing lead-induced damages, the decrease of lead accumulation is also critical. This study has been the first attempt to investigate effects of meso-2,3-dimercaptosuccinic acid (DMSA), potassium iodide (KI) and chlorophyll (Chl) on lead accumulation in male mice. MATERIAL AND METHODS: Eighty healthy Kunming male mice were selected and divided randomly into 8 groups...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28220808/corrigendum-structures-phase-transitions-and-tricritical-behavior-of-the-hybrid-perovskite-methyl-ammonium-lead-iodide
#14
P S Whitfield, N Herron, W E Guise, K Page, Y Q Cheng, I Milas, M K Crawford
No abstract text is available yet for this article.
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218540/perovskite-like-organic-inorganic-hybrid-lead-iodide-with-a-large-organic-cation-incorporated-within-the-layers
#15
Chen-Jie Que, Chong-Jiao Mo, Zhao-Qi Li, Guang-Lin Zhang, Qin-Yu Zhu, Jie Dai
A great effort has been made to investigate 2D perovskites to improve the stability and controllability in the fabrication of photoelectronic devices. As far as we know, only small organic cations such as methylammonium can incorporate into the multilayered perovskite structure except the cations sandwiched between the inorganic layers. We report here a new layered lead iodide, (H2Aepz)3Pb4I14 (1), where larger organic cations, bis-protonated 2-(2-aminoethyl)pyrazole (Aepz), not only were sandwiched between the inorganic layers but also were incorporated within the perovskite-like PbI layered structure...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28217845/probing-zeolite-crystal-architecture-and-structural-imperfections-using-differently-sized-fluorescent-organic-probe-molecules
#16
Bert Marc Weckhuysen, Frank Hendriks, Joel Schmidt, Jeroen Rombouts, Koen Lammertsma, Pieter Bruijnincx
A micro-spectroscopic method has been developed to probe the accessibility of zeolite crystals using a series of fluorescent 4-(4-diethylaminostyryl)-1-methylpyridinium iodide (DAMPI) probes of increasing molecular size. Staining of large zeolite crystals with MFI topology and subsequent mapping of the resulting fluorescence using confocal fluorescence microscopy reveal differences in structural integrity: the 90° intergrowth sections of MFI crystals are prone to develop structural imperfections, which act as entrance routes for the probes into the zeolite crystal...
February 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28216894/cytotoxic-activities-of-naturally-occurring-oleanane-ursane-and-lupane-type-triterpenes-on-hepg2-and-ags-cells
#17
Heejung Yang, Hyun Woo Kim, Young Choong Kim, Sang Hyun Sung
BACKGROUND: It is well known that the naturally occurring modified triterpenes in plants have a wide diversity of chemical structures and biological functions. The lupane-, oleanane-, and ursane-type triterpenes are the three major members of natural triterpenes with a wide range of biological properties. A systematic approach is necessary to review their structures and biological activities according to the backbones and the different substituents. OBJECTIVE: Thirty lupane-(L1-7), oleanane-(O1-14), and ursane-type (U1-9) triterpenes with structural diversity were examined to evaluate their cytotoxic activities against two cancer cell lines, human hepatocellular carcinoma (HepG2) and AGS cells...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28215962/two-colour-fluorescence-fluorimetric-analysis-for-direct-quantification-of-bacteria-and-its-application-in-monitoring-bacteria-growth-in-cellulose-degradation-systems
#18
Kwabena O Duedu, Christopher E French
Monitoring bacterial growth is an important technique required for many applications such as testing bacteria against compounds (e.g. drugs), evaluating bacterial composition in the environment (e.g. sewage and wastewater or food suspensions) and testing engineered bacteria for various functions (e.g. cellulose degradation). T?=1,^FigItem(1) ^ReloadFigure=Yesraditionally, rapid estimation of bacterial growth is performed using spectrophotometric measurement at 600nm (OD600) but this estimation does not differentiate live and dead cells or other debris...
February 16, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28214774/multimodality-imaging-of-bone-marrow-derived-dendritic-cell-migration-and-antitumor-immunity
#19
Su-Bi Ahn, Sang Bong Lee, Thoudam Debraj Singh, Sung Jin Cho, Sang Kyoon Kim, In-Kyu Lee, Shin Young Jeong, Byeong-Cheol Ahn, Jaetae Lee, Sang-Woo Lee, Yong Hyun Jeon
Here, we sought to monitor bone marrow-derived dendritic cell (BMDC) migration and antitumor effects using a multimodal reporter imaging strategy in living mice. BMDCs were transduced with retroviral vector harboring human sodium iodide symporter (hNIS, nuclear imaging reporter), firefly luc2 (optical imaging reporter), and thy1.1 (surrogate marker of NIS and luc2) genes (BMDC/NF cells). No significant differences in biological functions, including cell proliferation, antigen uptake, phenotype expression, and migration ability, were observed between BMDC and BMDC/NF cells...
February 16, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28214242/injury-and-recovery-of-escherichia-coli-atcc25922-cells-treated-by-high-hydrostatic-pressure-at-400-600%C3%A2-mpa
#20
Keitarou Kimura, Kazuya Morimatsu, Takashi Inaoka, Kazutaka Yamamoto
Escherichia coli cells were inactivated by high hydrostatic pressure (HHP) at 400-600 MPa and their recovery under various conditions was evaluated by colony counting and flow cytometer (FCM) analyses. The lag time in colony formation and an improved recovery of cells under less oxidative conditions (pyruvate addition to the medium and incubation in anaerobic conditions) were observed for HHP treated cells, which indicated that a significant portion of cells were injured and recovered during incubation after HHP treatment...
February 14, 2017: Journal of Bioscience and Bioengineering
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