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https://www.readbyqxmd.com/read/28098962/gold-catalyzed-suzuki-coupling-of-ortho-substituted-hindered-aryl-substrates
#1
Nejib Dwadnia, Julien Roger, Nadine Pirio, Hélène Cattey, Ridha Ben Salem, Jean-Cyrille Hierso
A method that allows hindered ortho-substituted aryl iodides to be efficiently coupled to phenylboronic acid using a gold-catalyzed C-C bond formation is presented. The use of a molecularly-defined dinuclear gold chloride catalytic precursor that is stabilized by a new tetradentate (N,N')-diamino-(P,P')-diphosphino ferrocene hybrid ligand in a Suzuki-type reaction is described for the first time. Electron-rich isopropyl groups on phosphorus were found essential for a superior activity, while the performances of a set of analogous gold dinuclear complexes that were fully characterized by multinuclear NMR spectroscopy and XRD analysis, were investigated...
January 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28098861/triptolide-inhibits-viability-and-induces-apoptosis-in-liver-cancer-cells-through-activation-of-the-tumor-suppressor-gene-p53
#2
Yan-Yan Sun, Lei Xiao, Dong Wang, Yan-Chao Ji, Yu-Peng Yang, Rong Ma, Xi-Hai Chen
The present study investigated the effect of triptolide on viability and apoptosis along with underlying mechanism in liver cancer cells. CCK-8 assay showed that triptolide treatment for 48 h significantly reduced the viability of HepG2 and QSG7701 cells at 50 µM concentration. Annexin V-FITC and propidium iodide staining showed that triptolide treatment of HepG2 cells at 50 µM concentrations induced apoptosis in 56.45% cells compared to only 2.36% cells in the control cultures. Western blot assay showed that treatment of HepG2 cells with 50 µM concentration of triptolide significantly induced phosphorylation of p53 in a 2 h-treatment...
January 16, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28098666/estimated-internal-and-external-radiation-exposure-of-caregivers-of-patients-with-pediatric-neuroblastoma-undergoing-131i-metaiodobenzylguanidine-therapy-a-prospective-pilot-study
#3
Sangwon Han, Seon Hee Yoo, Kyung-Nam Koh, Jong Jin Lee
PURPOSE: Current recommendations suggest that family members should participate in the care of children receiving in-hospital I metaiodobenzylguanidine (MIBG) therapy for neuroblastoma. The present study aimed to measure the external radiation exposure and estimate the internal radiation exposure of caregivers during the hospital stay for I MIBG therapy. MATERIALS AND METHODS: Caregivers received radiation safety instructions and a potassium iodide solution for thyroid blockade before patient admission...
January 16, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28098405/shielding-engineered-islets-with-mesenchymal-stem-cells-enhance-survival-under-hypoxia
#4
Bhawna Chandravanshi, Ramesh Ramchandra Bhonde
In the present study we focused on the improvisation of islet survival in hypoxia.The Islet like cell aggregates (ICAs) derived from wharton's jelly mesenchymal stem cells (WJ MSC) were cultured with and without WJ MSC for 48h in hypoxia and normoxia and tested for their direct trophic effect on β cell survival. The WJ MSCs themselves secreted insulin upon glucose challenge and expressed the pancreatic markers at both transcription and translational level (C-peptide, Insulin,Glucagon and Glut 2). Direct contact of MSCs with ICAs facilitated highest viability under hypoxia as evidenced by fluorescein diacetate/propidium iodide and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay...
January 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28098311/transition-metal-free-direct-trifluoromethylthiolation-of-indoles-using-trifluoromethanesulfonyl-chloride-in-the-presence-of-triphenylphosphine
#5
Kui Lu, Zhijie Deng, Ming Li, Tianjiao Li, Xia Zhao
A novel triphenylphosphine-mediated direct trifluoromethylthiolation of indole derivatives using trifluoromethanesulfonyl chloride as the SCF3 source was developed. Sodium iodide facilitated this transformation by generating iodine in situ which was found to accelerate this transformation. The use of a transition metal-free protocol, readily available reagents, and mild reaction conditions allowed this protocol to be easily scaled up.
January 18, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28096959/the-effect-of-aminoguanidine-on-sperm-motility-and-mitochondrial-membrane-potential-in-varicocelized-rats
#6
Rafieh Alizadeh, Shadan Navid, Niloofar Abbasi, Abazar Yari, Zohreh Mazaheri, Erfan Daneshi, Ashok Agarwal, Mehdi Abbasi
OBJECTIVES: Increased levels of nitric oxide (NO) in the testicular veins of people suffering from varicocele have already been reported. However, the role of NO-synthase (NOS) isozymes and their inhibitors have not been extensively studied. We aimed to evaluate the inhibitory effects of aminoguanidine (AG), on sperm motility, vitality, and mitochondrial membrane potential (MMP) in varicocelized rats. MATERIALS AND METHODS: Twenty fore male Wister rats were divided into control, sham, varicocele, and treatment groups...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28096658/anticancer-and-anti-inflammatory-activities-of-girinimbine-isolated-from-murraya-koenigii
#7
Venoos Iman, Syam Mohan, Siddig Ibrahim Abdelwahab, Hamed Karimian, Noraziah Nordin, Mehran Fadaeinasab, Mohamad Ibrahim Noordin, Suzita Mohd Noor
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. Murraya koenigii is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a carbazole alkaloid isolated from M. koenigii, induced apoptosis and inhibited inflammation in vitro as well as in vivo. Induction of apoptosis in human colon cancer cells (HT-29) by girinimbine revealed decreased cell viability in HT-29, whereas there was no cytotoxic effect on normal colon cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28096342/eight-coordinate-fluoride-in-a-silicate-double-four-ring
#8
Maarten G Goesten, Roald Hoffmann, F Matthias Bickelhaupt, Emiel J M Hensen
Fluoride, nature's smallest anion, is capable of covalently coordinating to eight silicon atoms. The setting is a simple and common motif in zeolite chemistry: the box-shaped silicate double-four-ring (D4R). Fluoride seeks its center. It is the strain of box deformation that keeps fluoride in the middle of the box, and freezes what would be a transition state in its absence. Hypervalent bonding ensues. Fluoride's compactness works to its advantage in stabilizing the cage; chloride, bromide, and iodide do not bring about stabilization due to greater steric repulsion with the box frame...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28094946/competing-e2-and-sn2-mechanisms-for-the-f-ch3ch2i-reaction
#9
Li Yang, Jiaxu Zhang, Jing Xie, Xinyou Ma, Linyao Zhang, Chenyang Zhao, William Louis Hase
Anti-, syn-E2 and inv-, ret-SN2 reaction channels for the gas-phase reaction of F- + CH3CH2I were characterized with a variety of electronic structure calculations. A geometrical analysis confirmed the synchronous E2-type transition states for the elimination of current reaction, instead of nonconcerted processes through E1cb-like and E1-like mechanisms. Importantly, the controversy concerning reactant complex for anti-E2 and inv-SN2 paths have been clarified in the present work. A positive barrier of + 19...
January 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28094926/the-room-temperature-superionic-conductivity-of-silver-iodide-nanoparticles-under-pressure
#10
Takayuki Yamamoto, Mitsuhiko Maesato, Naohisa Hirao, Saori I Kawaguchi, Shogo Kawaguchi, Yasuo Ohishi, Yoshiki Kubota, Hirokazu Kobayashi, Hiroshi Kitagawa
We performed variable-temperature synchrotron powder X-ray diffraction measurements and impedance spectroscopy under pressure for silver iodide (AgI) nanoparticles with a diameter of 11 nm. The superionic conducting α-phase of AgI nanoparticles was successfully stabilized down to at least 20 °C by applying a pressure of 0.18 GPa, whereas the transition temperature was 147 °C in bulk AgI at ambient pressure. To our knowledge, this is the first example of the α-phase of AgI existing stably at room temperature...
January 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28094249/thermal-engineering-of-fapbi3-perovskite-material-via-radiative-thermal-annealing-and-in-situ-xrd
#11
Vanessa L Pool, Benjia Dou, Douglas G Van Campen, Talysa R Klein-Stockert, Frank S Barnes, Sean E Shaheen, Md I Ahmad, Maikel F A M van Hest, Michael F Toney
Lead halide perovskites have emerged as successful optoelectronic materials with high photovoltaic power conversion efficiencies and low material cost. However, substantial challenges remain in the scalability, stability and fundamental understanding of the materials. Here we present the application of radiative thermal annealing, an easily scalable processing method for synthesizing formamidinium lead iodide (FAPbI3) perovskite solar absorbers. Devices fabricated from films formed via radiative thermal annealing have equivalent efficiencies to those annealed using a conventional hotplate...
January 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28093932/involvement-of-p53-and-bcl-2-in-sensory-cell-degeneration-in-aging-rat-cochleae
#12
Yang Xu, Wei Ping Yang, Bo Hua Hu, Shiming Yang, Donald Henderson
CONCLUSION: p53 and Bcl-2 (B-cell lymphoma 2) are involved in the process of sensory cell degeneration in aging cochleae. OBJECTIVE: To determine molecular players in age-related hair cell degeneration, this study examined the changes in p53 and Bcl-2 expression at different stages of apoptotic and necrotic death of hair cells in aging rat cochleae. METHODS: Young (3-4 months) and aging (23-24 months) Fisher 344/NHsd rats were used. The thresholds of the auditory brainstem response (ABR) were measured to determine the auditory function...
January 17, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28093820/synthesis-of-2-2-2-trichloroethyl-aryl-and-vinyldiazoacetates-by-palladium-catalyzed-cross-coupling
#13
Huw Davies, Liangbing Fu, Jeffrey Mighion, Eric Voight
An efficient and convenient synthesis of 2,2,2-trichloroethyl (TCE) aryl- and vinyldiazoacetates was achieved by palladium-catalyzed cross-coupling reactions between TCE diazoacetates and aryl or vinyl iodides. The broad substrate scope allows for rapid and facile formation of TCE aryl- and vinyl-diazoacetates, which recently have emerged as versatile reagents for rhodium-carbene chemistry.
January 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28093223/cytotoxicity-and-apoptosis-induced-by-mixed-mycotoxins-t-2-and-ht-2-toxin-on-primary-hepatocytes-of-broilers-in-vitro
#14
Lingchen Yang, Di Tu, Zhiyong Zhao, Jun Cui
T-2 and HT-2 (T-2/HT-2) induced cytotoxicity and apoptosis in hepatocytes from broilers. In this study, hepatocytes treated with T-2/HT-2 were analyzed for cytotoxic effects and apoptosis and for the associated mechanisms. To assay cytotoxicity, we used the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) viability assay, hematoxylin-eosin staining and aspartase transaminase and alanine transaminase (ALT/AST) activities. We evaluated apoptosis by fluorescence microscopy using the Terminal transferase nick-end labeling (TUNEL) assay...
January 13, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28092843/therapeutic-effects-of-bach1-sirna-on-human-breast-adenocarcinoma-cell-line
#15
Mansoor Aletaha, Behzad Mansoori, Ali Mohammadi, Mehdi Fazeli, Behzad Baradaran
BACKGROUND: Despite the great improvements in clinical and therapeutic techniques in recent years, many advanced breast cancer patients still died of the postoperative recurrence and metastasis of disease. Bach1 plays a role in the development of the invasive phenotypes of cancer, cell division and apoptosis in tumor cells. The aim of this study was to investigate the effect of specific bach1 siRNAs, on the proliferation, migration, invasive, induction of apoptosis, cell cycle arrest and alter EMT related miRNA of MDA-MB-468 cells (breast cancer)...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28092159/probe-decomposition-of-methylammonium-lead-iodide-perovskite-in-n2-and-o2-by-in-situ-infrared-spectroscopy
#16
Xiaozhou Yu, Ying Qin, Qing Peng
Packaging methylammonium lead iodide perovskite (MAPbI3) based solar cells with a controlled gaseous atmosphere, such as N2 or dry air, is a promising solution for its application as outdoor photovoltaics. However, the effect of N2 and O2 on the decomposition chemistry and kinetics of MAPbI3 is not well understood yet. With in-situ Fourier transform infrared spectroscopy measurements, we show that the effective activation energy for the degradation of MAPbI3 in N2 is ~ 120 kJ/mol. The decomposition of MAPbI3 is greatly enhanced when MAPbI3 is exposed to O2...
January 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28089496/cell-toxicity-in-fibroblasts-tenocytes-and-human-mesenchymal-stem-cells-a-comparison-of-necrosis-and-apoptosis-inducing-ability-in-ropivacaine-bupivacaine-and-triamcinolone
#17
Anja Z Zhang, Andreas Ficklscherer, Mehmet F Gülecyüz, Alexander C Paulus, Thomas R Niethammer, Volkmar Jansson, Peter E Müller
PURPOSE: To analyze the ability of ropivacaine, bupivacaine, and triamcinolone to induce apoptosis and necrosis in fibroblasts, tenocytes, and human mesenchymal stem cells. METHODS: Human dermal fibroblasts, adipose-derived human mesenchymal stem cells (hMSCs), and tenocytes gained from the rotator cuff tendon were seeded with a cell density of 0.5 × 10(4)/cm(2). One specimen of ropivacaine, bupivacaine, and triamcinolone was tested separately on the cells with separate concentrations of 0...
January 12, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28088623/a-novel-role-of-topical-iodine-in-skin-activation-of-the-nrf2-pathway
#18
Maya Ben-Yehuda Greenwald, Marina Frušić-Zlotkin, Yoram Soroka, Shmuel Ben-Sasson, Havazelet Bianco-Peled, Ron Kohen
For a long time iodine has been used as an active dermal agent in the treatment of inflammatory, immune-mediated and infectious diseases. Moreover, topical iodine application has been reported to provide protection against sulfur-mustard-induced skin lesions, heat-induced and acid-induced skin burns in both haired guinea-pigs and mouse ear swelling models. However, the exact mechanism of action underlying these benefits of iodine has not yet been elucidated. In the current study, a novel mechanism of action by which iodine provides skin protection and relief, based on its electrophilic nature, is suggested...
January 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28087376/ir780-loaded-tpgs-tos-micelles-for-breast-cancer-photodynamic-therapy
#19
Cleide Pais-Silva, Duarte de Melo-Diogo, Ilídio J Correia
IR780 iodide is a near-infrared (NIR) dye with a huge potential for cancer imaging and phototherapy. However, its biomedical application is strongly impaired by its lipophilic character. Herein, amphiphilic micelles based on d-α-tocopheryl polyethylene glycol succinate (TPGS) and d-α-tocopheryl succinate (TOS), two vitamin E derivatives with intrinsic anticancer activity, are explored to load IR780. IR780-loaded micelles with suitable sizes are obtained by using specific TPGS and TOS weight feed ratios during micelles formulation and these are able to encapsulate IR780 with high efficiency...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28081367/ordered-mesoporous-titanium-nitride-as-a-promising-carbon-free-cathode-for-aprotic-lithium-oxygen-batteries
#20
Byung Gon Kim, Changshin Jo, Jaeho Shin, Yeongdong Mun, Jinwoo Lee, Jang Wook Choi
Despite the extraordinary gravimetric energy densities, Li-O2 batteries are still facing a technological challenge; limited round trip efficiency leading to insufficient cycle life. Recently, carbonaceous electrode materials were found to be one of the primary origins of the limited cycle life, as they produce irreversible side products during discharge. A few investigations based on non-carbonaceous materials have demonstrated largely suppressed accumulation of irreversible side products but such studies have focused mainly on the materials themselves rather than delicate morphology control...
January 12, 2017: ACS Nano
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