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Nikolai A Tcyrulnikov, Anastasiia A Tikhomirova, Sergei Tcyrulnikov, R Marshall Wilson
The tetrapyridinium salt 1 was found to undergo quantitative air oxidation upon dissolving it in water. The corresponding alkene and the epoxide were found as the only products of the oxidation. A mechanism that involves an alkyl hydroperoxide intermediate 1″ undergoing a transformation that yields both products is proposed. Air oxidation of 1 shows the potential of the acceptor substituted alkanes to be used in the studies of mostly unknown direct epoxidation of single C-C bonds.
February 19, 2018: Organic Letters
Juan Li, Jin Jiang, Su-Yan Pang, Yang Zhou, Yuan Gao, Yi Yang, Shaofang Sun, Guanqi Liu, Jun Ma, Chengchun Jiang, Lihong Wang
This work investigated impacts of iodide (I- ) on the transformation of the widely used phenolic preservative methylparaben (MeP) as well as 11 other phenolic compounds by potassium permanganate (KMnO4 ). It was found that KMnO4 showed a low reactivity towards MeP in the absence of I- with apparent second-order rate constants (kapp ) ranging from 0.065 ± 0.0071 to 1.0 ± 0.1 M-1 s-1 over the pH range of 5-9. The presence of I- remarkably enhanced the transformation rates of MeP by KMnO4 via the contribution of hypoiodous acid (HOI) in situ formed, which displayed several orders of magnitude higher reactivity towards MeP than KMnO4 ...
February 10, 2018: Water Research
Sanil D Singh, Naeem Sheik-Abdul, Alisa Phulukdaree, Charlette Tiloke, Savani Nagiah, Sooraj Baijnath, Anil A Chuturgoon
Raw ingredients of pet food are often contaminated with mycotoxins. This is a serious health problem to pets and causes emotional and economical stress to the pet owners. The aim of this study was to determine the immunotoxicity of the most common mycotoxins (aflatoxin, fumonisin, ochratoxin A and zearalenone) by examining 20 samples of extruded dry dog food found on the South African market [10 samples from standard grocery store lines (SB), 10 from premium veterinarian lines (PB)]. Pelleted dog food was subjected to extraction protocols optimized for the above mentioned mycotoxins...
February 13, 2018: Food and Chemical Toxicology
Zbigniew M Szczepiorkowski, Christine A Burnett, Larry J Dumont, Sunil H Abhyankar
BACKGROUND: Extracorporeal photopheresis (ECP) has been approved for the treatment of advanced cutaneous T-cell lymphoma since 1988. While the precise mechanisms resulting in clinical effects are not fully understood, the photoactivation of mononuclear cells (MNCs) using ultraviolet A (UVA) light and methoxsalen is believed to be the predominant initiating process. The effects of MNC passage through the instrument without photoactivation are unknown. The objective of this study was to evaluate the effect of cell processing through the photopheresis instruments on MNCs...
February 16, 2018: Transfusion
Kazuya Kiriyama, Keisho Okura, Fumiko Tamakuni, Eiji Shirakawa
The coupling reaction of magnesium diarylamides with aryl iodides was found to proceed through single electron transfer mechanism to give triarylamines with no aid of a transition metal catalyst and an additive.
February 15, 2018: Chemistry: a European Journal
Hong Xiao, Jian Zhou, Xing Liu, Hongping Xiao, Rute A S Ferreira, Luís D Carlos, Lianshe Fu
A novel 3-D cuprous iodide polymer [CuI(μ 6 -L)] n with a Cu/I ratio as high as 3 (1, H 2 L = 1,3-bis(2H-tetrazol-5-yl)benzene) has been hydrothermally synthesized. The 3-D framework of 1 is constructed by the linkages of rare 1-D cationic aggregates [CuI 2+ ] n and anionic bi-tetrazolate bridges. 1 shows unusually thermochromic luminescent and photocatalytic properties, and its density functional theory calculation has also been studied.
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Mark Lötzerich, Pascal S Roulin, Karin Boucke, Robert Witte, Oleg Georgiev, Urs F Greber
Apoptosis and programmed necrosis (necroptosis) determine cell fate, and antagonize infection. Execution of these complementary death pathways involves the formation of receptor-interacting protein kinase 1 (RIPK1) containing complexes. RIPK1 binds to adaptor proteins, such as TRIF (Toll-IL-1 receptor-domain-containing-adaptor-inducing interferon-beta factor), FADD (Fas-associated-protein with death domain), NEMO (NF-κB regulatory subunit IKKγ), SQSTM1 (sequestosome 1/p62), or RIPK3 (receptor-interacting protein kinase 3), which are involved in RNA sensing, NF-κB signaling, autophagosome formation, apoptosis, and necroptosis...
February 15, 2018: Cell Death & Disease
Brady D Lee, Joshua T Ellis, Alex Dodwell, Emalee E R Eisenhauer, Danielle L Saunders, M Hope Lee
Nitrate and radioiodine ( 129 I) contamination is widespread in groundwater underneath the Central Plateau of the Hanford Site. 129 I, a byproduct of nuclear fission, is of concern due to a 15.7 million year half-life, and toxicity. The Hanford 200 West Area contains plumes covering 4.3 km 2 with average 129 I concentrations of 3.5 pCi/L. Iodate accounts for 70.6% of the iodine present and organo-iodine and iodide make up 25.8% and 3.6%, respectively. Nitrate plumes encompassing the 129 I plumes have a surface area of 16 km 2 averaging 130 mg/L...
February 6, 2018: Journal of Hazardous Materials
Zhi-Yang Xie, Lu Chen, Cong Zhang, Lei Liu, Feng Wang, Feng Cai, Xiao-Hu Wang, Rui Shi, Arjun Sinkemani, Hao-Min Yu, Xin Hong, Xiao-Tao Wu
Acid-sensing ion channel 1a (ASIC1a) participates in human intervertebral disc degeneration (IVDD) and regulates the destiny of nucleus pulposus cells (NPCs) in acid stimulus. However, the mechanism of ASIC1a activation and its downstream pathway remain unclear. Endoplasmic reticulum (ER) stress also participates in the acid-induced apoptosis of NPCs. The main purpose of this study was to investigate whether there is any connection between ASIC1a and ER stress in an acid-induced nucleus pulposus degeneration model...
2018: BioResearch Open Access
Sophie Becker, Dr Volker Bickert, Kai Reimers, Dr Martin Becker
In order to further clarify if and how much Ozone is generated during HVLD and to identify measures to reduce the impact of Ozone generation on product quality a highly sensitive analytical system [4] was employed to investigate the generation of Ozone at different operational conditions of HVLD integrity testing. The analytical system is based on oxidation of Iodide ions in solution and identification of the Iodine formed by N, N-Diethyl-p-phenylendiamine (DPD) according to DIN 38403 [4].Sensitivity of the system was found suitable to detect Ozone levels as low as 0...
February 14, 2018: PDA Journal of Pharmaceutical Science and Technology
Wang Chengzheng, Wen Jiazhi, Chen Shuangjiang, Mallappa Kumara Swamy, Uma Rani Sinniah, Mohd Sayeed Akhtar, Ahmad Umar
Nanobiotechnology has emerged as a promising technology to develop new therapeutically active nanomaterials. The present study was aimed to biosynthesize AgNPs extracellularly using Aspergillus niger JX556221 fungal extract and to evaluate their anticancer potential against colon cancer cell line, HT-29. UV-visible spectral characterization of the synthesized AgNPs showed higher absorption peak at 440 nm wavelength. Transmission Electron Microscopy (TEM) analysis revealed the monodispersed nature of synthesized AgNPs occurring in spherical shape with a size in the range of 20-25 nm...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Shengtao Xu, Guangyu Wang, Feijie Xu, Wenlong Li, Aijun Lin, Hequan Yao, Jinyi Xu
A concise and protecting-group-free total synthesis of the antiproliferative natural product (±)-deguelin (2) was accomplished in four steps and 62% overall yield from commercially available precursors. The key transformation employed a vinyl iodide as the pivotal building block to construct the 4-acylchromene substructure present in deguelin. Subsequent Cu2O-mediated α-hydroxylation of deguelin (2) afforded tephrosin (3) in 90% yield.
February 14, 2018: Journal of Natural Products
Sagar Bhatta, Cristina Ratti, Patrice E Poubelle, Tatjana Stevanovic
Sugar maple (Acer saccharum M.) and red maple (Acer rubrum L.) barks were treated with hot water to extract nutrients in order to explore, for the first time, its potential as safe dietary antioxidants. The organic and inorganic nutrients of these extracts, as well as their safety on human PLB-985 cells differentiated into neutrophils-like cells, were determined. Proximate analysis showed that both bark extracts were low in moisture and fat. Sugar maple bark extract (SM-BX) showed crude protein and ash content higher than those found in red maple bark extract (RM-BX)...
February 13, 2018: Plant Foods for Human Nutrition
Evamarie Hey-Hawkins, Jan Schulz, Anika Kreienbrink, Peter Coburger, Benedikt Schwarze, Toni Grell, Peter Lönnecke
Carborane-substituted 1,2-diphosphetanes (Ia,b) react with lithium in THF with cleavage of the P-P bond to give a deep red solution from which red crystals of a lithiated intermediate, [{1-PtBuLi(THF)-6-PtBu-4,1,6-closo-Li(THF)C2B10H10}{Li(THF)3}]2∙ 2 THF (2), were obtained. The compound is dimeric and contains six Li and four P atoms. Two Li atoms are capping the six-membered C2B4 faces resulting in two 13-vertex closo-clusters with docosahedral geometry. Addition of MeI resulted in formation of the zwitterionic bis-phosphonium-nido-carborates, 7,10-bis(tert-butyl-dimethylphosphonium)-dodecahydro-7,10-dicarba-nido-dodecaborate(2-) (1a) and 7,10-bis(N,N-diisopropylamino-dimethylphosphonium)-dodecahydro-7,10-dicarba-nido-dodecaborate(2-) (1b) in moderate to good yields...
February 13, 2018: Chemistry: a European Journal
Antonio De la Vieja, Pilar Santisteban
Iodide (I-) metabolism is crucial for the synthesis of thyroid hormones (THs) in the thyroid and the subsequent action of these hormones in the organism. I- is principally transported by the sodium iodide symporter (NIS) and by the anion exchanger PENDRIN, and recent studies have demonstrated the direct participation of new transporters including anoctamin 1 (ANO1), cystic fibrosis transmembrane conductance regulator (CFTR) and sodium multivitamin transporter (SMVT). Several of these transporters have been found expressed in various tissues, implicating them in I- recycling...
February 1, 2018: Endocrine-related Cancer
Thomas Gehrke, Stephan Hackenberg, Bülent Polat, Gisela Wohlleben, Rudolf Hagen, Norbert Kleinsasser, Agmal Scherzad
The antibiotic drug salinomycin has been reported to mediate cancer cell-specific cytotoxicity, especially regarding cancer stem cells. Since salinomycin has also been reported to arrest cancer cells in the G2 phase, it may have possible radiosensitizing effects. Radiotherapy is a common therapeutic strategy for head and neck squamous cell carcinoma (HNSCC). The aim of the present study was to evaluate a possible influence of salinomycin on the radiosensitivity of the HNSCC cell line HLaC-78 in vitro. HLaC-78 cells were incubated with 5 µM salinomycin or control medium for 24 h and then received 5-Gy irradiation...
February 13, 2018: Oncology Reports
Seung Taek Lim, Ye Won Jeon, Hongki Gwak, Se Young Kim, Young Jin Suh
The Janus kinase (JAK)1 and JAK2 inhibitor, ruxolitinib, and the active form of vitamin D (calcitriol) were previously reported to possess anticancer effects in breast cancer. The present study investigated the combined effects of ruxolitinib and calcitriol on an estrogen receptor (ER)‑positive, human epidermal growth factor receptor 2 (HER2)‑positive, breast cancer cell line. The ER and HER2‑positive MCF7‑HER18 breast cancer cell line was used to investigate the combination effect of ruxolitinib and calcitriol...
February 8, 2018: Molecular Medicine Reports
Ning Zeng, Tang Hongbo, Yi Xu, Min Wu, Yiping Wu
Skin cancer is one of the primary causes of mortality worldwide. With an increasing frequency of skin cancers, there is an urgent requirement for the development of numerous treatment options. The present study investigated the anticancer activity of caffeic acid n‑butyl ester (CAE) against the A431 skin cancer cell line. Antiproliferative effects were investigated using an MMT assay. Apoptosis was examined by DAPI and Annexin V/fluorescein isothiocyanate and propidium iodide staining. Reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and cell cycle analyses were performed via flow cytometry...
February 13, 2018: Molecular Medicine Reports
Donghui Zhou, Yong Zhou, Chao Li, Lina Yang
B7-H4 is a transmembrane protein which is a member of the B7 superfamily. It is overexpressed in various types of cancer, including gastric cancer. However, the effects of B7-H4 on the tumorigenicity of gastric cancer and the underlying mechanisms have not yet been fully explored. Thus, the aim of this study was to examine the effects of B7-H4 on the tumorigenicity of gastric cancer cells and to elucidate the underlying mechanisms. For this purpose, B7-H4 expression in gastric cancer tissues was detected by immunohistochemical staining...
February 13, 2018: International Journal of Oncology
Yessica Cristina Castellanos-Esparza, Shuang Wu, Limin Huang, Catherine Buquet, Rong Shen, Berenice Sanchez-Gonzalez, Ethel Awilda García Latorre, Olivier Boyer, Remi Varin, Luis Antonio Jiménez-Zamudio, Anne Janin, Jean-Pierre Vannier, Hong Li, He Lu
Pentoxifylline (PTX), a xanthine family molecule and simvastatin (SIM), an anti-hypercholesterolemic agent, have recently been considered as sensitizers to chemotherapy and radiotherapy. The present in vitro study evaluated their antitumor synergistic effects on MDA‑MB‑231 breast cancer cells characterized by the triple‑negative phenotype (TNP). The anti-proliferative effects of these two agents were evaluated by MTT and clonogenic assays. Cell cycle progression was examined using propidium iodide staining...
February 9, 2018: International Journal of Oncology
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