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https://www.readbyqxmd.com/read/28829121/suppressing-lithium-dendrite-growth-with-a-single-component-coating
#1
Haodong Liu, Hongyao Zhou, Byoung-Sun Lee, Xing Xing, Matthew Gonzalez, Ping Liu
A single-component coating was formed on lithium metal in a lithium iodide/organic carbonates (dimethyl carbonate (DMC) and ethylene carbonate (EC)) electrolyte. LiI chemically reacts with dimethyl carbonate to form lithium methyl carbonate, which precipitates and forms the chemically homogeneous coating layer on Li surface. This coating layer is shown to enable dendrite free Li cycling in a symmetric Li||Li cell even at a current density of 3 mA cm-2. Adding EC to DMC modulates the formation of the lithium methyl carbonate, resulting in a stable coating layer which is essential for long term Li cycling stability...
August 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28828244/freeze-thaw-decellularization-of-the-trabecular-meshwork-in-an-ex-vivo-eye-perfusion-model
#2
Yalong Dang, Susannah Waxman, Chao Wang, Adrianna Jensen, Ralitsa T Loewen, Richard A Bilonick, Nils A Loewen
OBJECTIVE: The trabecular meshwork (TM) is the primary substrate of outflow resistance in glaucomatous eyes. Repopulating diseased TM with fresh, functional TM cells might be a viable therapeutic approach. Decellularized TM scaffolds have previously been produced by ablating cells with suicide gene therapy or saponin, which risks incomplete cell removal or dissolution of the extracellular matrix, respectively. We hypothesized that improved trabecular meshwork cell ablation would result from freeze-thaw cycles compared to chemical treatment...
2017: PeerJ
https://www.readbyqxmd.com/read/28826240/biosynthesis-characterization-of-magnetic-iron-oxide-nanoparticles-and-evaluations-of-the-cytotoxicity-and-dna-damage-of-human-breast-carcinoma-cell-lines
#3
Ghassan M Sulaiman, Amer T Tawfeeq, Amal S Naji
Magnetic iron oxide nanoparticles (MNPs) were synthesized using Albizia adianthifolia leaf extract as reducing and protecting agent. Colour changing, UV-Vis spectrum, X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) confirmed the biosynthesis and characterization of MNPs. The XRD pattern revealed that MNPs are crystalline in nature. FT-IR spectral analysis showed that MNPs was capped with plant constituents. From SEM analysis, the MNPs were generally found to be spherical in shape and the size was ranged 32-100 nm...
August 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28822191/-polydatin-induces-human-cervical-cancer-cell-apoptosis-via-pi3k-akt-mtor-signaling-pathway
#4
Ji-Hong Pan, Hai-Bin Wang, Xiao-Fei Du, Jiang-Yue Liu, Dai-Juan Zhang
To observe the effect of polydatin on proliferation and apoptosis of cervical cancer HeLa cells and explore its possible mechanism. The growth inhibitory effect was detected with MTT assay. After HeLa cells were treated with different concentrations (50, 100, 150 μmol•L⁻¹) of polydatin, MTT assay was used to detect the inhibitory effect of polydatin on proliferation of HeLa cells; Acridine orange/ethidium bromide staining was used for morphological changes in apoptotic HeLa cells; Annexin/propidium iodide staining was applied to detect HeLa cell apoptotic rate...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28818311/characterization-of-the-flow-cytometric-assay-for-ex%C3%A2-vivo-monitoring-of-cytotoxicity-mediated-by-antigen-specific-cytotoxic-t-lymphocytes
#5
Akira Takagi, Yutaka Horiuchi, Masanori Matsui
Several non-radioactive methods have widely been utilized to detect antigen-specific cytotoxic T lymphocyte (CTL) responses instead of the classical (51)Cr-release assay. These methods include intracellular cytokine staining, major histocompatibility complex-class I tetramers, and the CD107a mobilization assay. However, they do not directly measure target-cell death. In contrast, several attempts have been made to develop the flow cytometric CTL (FC-CTL) assay for evaluation of cytotoxicity. However, further improvement is necessary for it to become standardized...
August 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28817225/anionic-palladium-0-and-palladium-ii-ate-complexes
#6
Marlene Kolter, Katharina Böck, Konstantin Karaghiosoff, Konrad Koszinowski
Palladium ate complexes are frequently invoked as important intermediates in Heck and cross-coupling reactions, but so far have largely eluded a characterization at the molecular level. Here, we use electrospray-ionization mass spectrometry, electrical conductivity measurements, and NMR spectroscopy to show that the electron-poor catalyst [L₃Pd] (L = tris[3,5-bis(trifluoromethyl)-phenyl]phosphine) readily reacts with Br- ions to afford the anionic, zero-valent ate complex [L₃PdBr]-. In contrast, more electron-rich Pd catalysts display lower tendencies toward the formation of ate complexes...
August 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28815948/flow-cytometric-analysis-of-viable-bacteria-in-urine-samples-of-febrile-patients-at-the-emergency-department
#7
Anne H Tavenier, Foppie J de Boer, Bijan Moshaver, Sjef J C M van der Leur, Coen A Stegeman, Paul H P Groeneveld
BACKGROUND: Fast and reliable diagnostics are important in febrile patients admitted to the emergency department. Current urine diagnostics are fast but moderately reliable or reliable but time consuming. Flow cytometry (FC) is a new promising technique in the diagnostics of complicated urinary tract infections by counting bacteria in urine samples. The aim of this study is to improve the FC method by counting only viable bacteria. METHODS: Urine was obtained from 135 consecutive febrile patients at the emergency department...
August 16, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28814477/iodine-excess-exposure-during-pregnancy-and-lactation-impairs-maternal-thyroid-function-in-rats
#8
Caroline Serrano-Nascimento, Rafael Salgueiro, Kaio Vitzel, Thiago Urgal Pantaleao, Vania Maria Correa da Costa, Maria Tereza Nunes
Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of the fetus. Indeed, iodine deficiency is clearly related to maternal hypothyroidism and deleterious effects in the fetal development. Conversely, the effects of iodine excess (IE) consumption on maternal thyroid function are still controversial. Therefore, this study aimed to investigate the impact of IE exposure during pregnancy and lactation periods on maternal hypothalamus-pituitary-thyroid axis...
August 16, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28813049/unprecedented-solvent-induced-inter-conversion-between-monomeric-and-dimeric-silylene-zinc-iodide-adducts
#9
Sandeep Yadav, Ekta Sangtani, Diksha Dhawan, Rajesh G Gonnade, Debashree Ghosh, Sakya S Sen
Usually, when a silylene reacts with a transition metal Lewis acid, it forms an adduct which could be either monomeric or dimeric. However, we present here that a silylene, [PhC(NtBu)2SiN(SiMe3)2] can form both monomeric [PhC(NtBu)2Si{N(SiMe3)2} → ZnI2]·THF (1) and dimeric [{PhC(NtBu)2}(N(SiMe3)2)SiZnI,(μ-I)]2 (2) adducts upon reaction with ZnI2. The formation of 1 and 2 relies upon the solvent used for the reaction or crystallization. When the crystallization is carried out in THF complex 1 is formed, however, when the reaction and crystallization are performed in acetonitrile complex 2 is obtained...
August 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28812082/a-broader-view-on-ion-heating-in-traveling-wave-devices-using-fragmentation-of-csi-clusters-and-extent-of-h%C3%AB-migration-as-molecular-thermometers
#10
Frederik Lermyte, Frank Sobott
Electron transfer dissociation (ETD) is becoming increasingly important in mass spectrometry-based analysis of peptides and proteins. Supplemental collisional activation of undissociated electron transfer products can significantly increase fragmentation yield and sequence coverage, but hydrogen rearrangements - specifically, transfer of a hydrogen radical from a c to a z fragment - lead to distorted isotope distributions and increased potential for signal overlap. Concomitant collisional activation during the ion/ion reaction significantly reduces these rearrangements, but, in ion traps, also leads to lower reaction rates and reduced overlap of anion and cation clouds...
August 16, 2017: Analyst
https://www.readbyqxmd.com/read/28810571/docosahexaenoic-acid-inhibits-the-phosphorylation-of-stat3-and-the-growth-and-invasion-of-renal-cancer-cells
#11
Shinsuke Tasaki, Akio Horiguchi, Takako Asano, Keiichi Ito, Tomohiko Asano, Hirotaka Asakura
Docosahexaenoic acid (DHA) has a variety of anti-tumor activities. The present study examined the anti-tumor activity of DHA in renal cancer cells and its underlying mechanisms of action. The effects of DHA on the viability and proliferation of the human renal cancer cell lines Caki-1 and 786-O were examined by an MTS assay and cell counting. In addition, cell cycle distribution and cell apoptosis were analyzed by flow cytometry and Annexin V staining, and modulation of cell mobility and invasiveness was assessed by wound healing and Matrigel invasion assays...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809968/spectroscopic-characterization-of-diiodomethyl-zinc-iodide-application-to-the-stereoselective-synthesis-and-functionalization-of-iodocyclopropanes
#12
Emmanuelle M D Allouche, Sylvain Taillemaud, André B Charette
Herein is described an improved synthetic route to enantio- and diastereoenriched iodocyclopropylmethanols using (diiodomethyl)zinc iodide etherate as the active species. The products obtained by this methodology were successfully functionalized by Suzuki-Miyaura cross-coupling reactions. A Buchwald-type palladium precatalyst allowed access to highly substituted and stereo-enriched cyclopropanes without requiring a protecting group.
August 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28809568/combinatorial-nickel-catalyzed-monofluoroalkylation-of-aryl-boronic-acids-with-unactivated-fluoroalkyl-iodides
#13
Jie Sheng, Hui-Qi Ni, Ge Liu, Yan Li, Xi-Sheng Wang
A combinatorial nickel-catalyzed cross-coupling between arylboronic acids and unactived 1-fluoro-1-iodoalkanes has been developed, which demonstrated high efficiency, mild conditions, and excellent functional-group compatibility. Readily available nitrogen and phosphine ligands were combined with a nitrogen source, which in situ generated a variety of easily tunable catalysts to promote the fluoroalkylation for broad scopes of both coupling partners. This new strategy on combinatorial catalysis offers new solutions for nickel-catalyzed cross-coupling reactions...
August 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28809558/aliphatic-c-sp3-h-bond-activation-using-nickel-catalysis-mechanistic-insights-on-regioselective-arylation
#14
Sukriti Singh, Surya K, Raghavan B Sunoj
Transition metal catalyzed C(sp3)-H bond activation in aliphatic compounds are of current interest. Lack of mechanistic insights on Ni-catalyzed C(sp3)-H activation using 8-aminoquinoline as a directing group motivated us to examine an interesting direct arylation of an aliphatic tertiary amide by using density functional theory. The catalysis employed Ni(II) pre-catalyst, 4-iodoanisole as an arylating agent, sodium carbonate and mesitylenic acid as additives in DMF solvent. Examination of a comprehensive set of mechanistic pathways helped us learn that the most preferred route begins with a bidentate chelate binding of deprotonated substrate to the Ni...
August 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28809506/stereospecific-palladium-catalyzed-c-h-arylation-of-pyroglutamic-acid-derivatives-at-the-c3-position-enabled-by-8-aminoquinoline-as-a-directing-group
#15
Oscar Verho, Micah Maetani, Bruno Melillo, Jochen Zoller, Stuart L Schreiber
An efficient and stereospecific Pd-catalyzed protocol for the C-H arylation of pyroglutamic acid derivatives that uses 8-aminoquinoline as a directing group is described. The reaction was shown to proceed efficiently with a variety of aryl and heteroaryl iodides bearing different functional groups, giving C3-arylated cis products in good to high yields. Removal of the 8-aminoquinoline unit from these C-H arylation products enables access to synthetically useful cis and trans pyroglutamic acid-based building blocks...
August 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28808378/rutamarin-an-active-constituent-from-ruta-angustifolia-pers-induced-apoptotic-cell-death-in-the-ht29-colon-adenocarcinoma-cell-line
#16
Shafinah Ahmad Suhaimi, Sok Lai Hong, Sri Nurestri Abdul Malek
BACKGROUND: Ruta angustifolia Pers. is a perennial herb that is cultivated worldwide, including Southeast Asia, for the treatment of various diseases as traditional medicine. OBJECTIVE: The purpose of the study was to identify an active principle of R. angustifolia and to investigate its effect on the HT29 cell death. MATERIALS AND METHODS: The methanol and fractionated extracts (hexane, chloroform, ethyl acetate, and water) of R. angustifolia Pers...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28806770/increasing-creatine-kinase-activity-protects-against-hypoxia-reoxygenation-injury-but-not-against-anthracycline-toxicity-in-vitro
#17
Sevasti Zervou, Hannah J Whittington, Philip J Ostrowski, Fang Cao, Jack Tyler, Hannah A Lake, Stefan Neubauer, Craig A Lygate
The creatine kinase (CK) phosphagen system is fundamental to cellular energy homeostasis. Cardiomyocytes express three CK isoforms, namely the mitochondrial sarcomeric CKMT2 and the cytoplasmic CKM and CKB. We hypothesized that augmenting CK in vitro would preserve cell viability and function and sought to determine efficacy of the various isoforms. The open reading frame of each isoform was cloned into pcDNA3.1, followed by transfection and stable selection in human embryonic kidney cells (HEK293). CKMT2- CKM- and CKB-HEK293 cells had increased protein and total CK activity compared to non-transfected cells...
2017: PloS One
https://www.readbyqxmd.com/read/28805393/disappearance-of-the-superionic-phase-transition-in-sub-5-nm-silver-iodide-nanoparticles
#18
Takayuki Yamamoto, Hirokazu Kobayashi, Loku Singgappulige Rosantha Kumara, Osami Sakata, Kiyofumi Nitta, Tomoya Uruga, Hiroshi Kitagawa
Bulk silver iodide (AgI) is known to show a phase transition from the poorly conducting β/γ-phases into the superionic conducting α-phase at 147 °C. Its transition temperature decreases with decreasing the size of AgI, and the α-phase exists stably at 37 °C in AgI nanoparticles with a diameter of 6.3 nm. In this Letter, we investigated the atomic configuration, the phase transition behavior, and the ionic conductivity of AgI nanoparticles with a diameter of 3.0 nm. The combination of pair distribution function (PDF) analysis and reverse Monte Carlo (RMC) modeling based on high-energy X-ray diffraction (XRD) revealed for the first time that they formed the β/γ-phases with atomic disorder...
August 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28803465/hypervalent-iodine-mediated-chemoselective-iodination-of-alkynes
#19
Yan Liu, Daya Huang, Ju Huang, Keiji Maruoka
Reported herein are practical approaches for the chemoselective mono-, di-, and tri-iodination of alkynes based on efficient oxidative iodinations catalyzed by hypervalent iodine reagents. The reaction conditions were systematically optimized by altering the iodine source and/or the hypervalent iodine reagent system. The tetrabutylammonium iodide (TBAI)/(diacetoxyiodo)benzene (PIDA) system is specific for mono-iodination, while the KI/PIDA system results in di-iodination. Combining the TBAI/PIDA and KI/PIDA systems in one pot provided the corresponding tri-iodination products efficiently...
August 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28803243/lithium-sensitivity-of-store-operated-ca2-entry-and-survival-of-fibroblasts-isolated-from-chorea-acanthocytosis-patients
#20
Lisann Pelzl, Bhaeldin Elsir, Itishri Sahu, Rosi Bissinger, Yogesh Singh, Basma Sukkar, Sabina Honisch, Ludger Schoels, Mohamed Jemaà, Elisabeth Lang, Alexander Storch, Andreas Hermann, Christos Stournaras, Florian Lang
BACKGROUND: The widely expressed protein chorein fosters activation of the phosphoinositide 3 kinase (PI3K) pathway thus supporting cell survival. Loss of function mutations of the chorein encoding gene VPS13A (vacuolar protein sorting-associated protein 13A) causes chorea-acanthocytosis (ChAc), a neurodegenerative disorder paralleled by deformations of erythrocytes. In mice, genetic knockout of chorein leads to enhanced neuronal apoptosis. PI3K dependent signalling upregulates Orai1, a pore forming channel protein accomplishing store operated Ca2+ entry (SOCE)...
August 11, 2017: Cellular Physiology and Biochemistry
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