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https://www.readbyqxmd.com/read/29045795/tbhp-tbai-mediated-oxidative-cascade-reaction-consisting-of-dimerization-cyclization-and-1-2-aryl-migration-metal-free-synthesis-of-pyrrolin-4-ones-and-highly-substituted-pyrroles
#1
Xiaoyuan Zhao, Yong Zhang, Jun Deng, Daisy Zhang-Negrerie, Yunfei Du
Treatment of enamino esters with TBHP (t-butylhydroperoxide) and TBAI (t-butylammonium iodide) in HFIP (hexafluoroisopropanol) was found to afford a variety of substituted pyrrolin-4-one compounds. This metal-free oxidative cascade reaction consists of key steps of coupling of two radical intermediates, intramolecular ring closure, and an exclusive 1,2-aryl radical migration. Upon treatment with base, the obtained pyrrolin-4-ones could be converted to the highly substituted pyrrole compounds.
October 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29042970/effects-of-17-dmag-on-diffuse-large-b-cell-lymphoma-cell-apoptosis
#2
Jia-Jia Li, Jing-Jing Zhang, Xiu Wang, Zi-Min Sun
17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a water soluble, semisynthetic derivative of endotoxin that has anticancer effects. The aim of the present study was to determine whether 17-DMAG enhances the apoptosis of lymphoma cells in diffuse large B-cell lymphoma. Apoptosis was induced in SU-DHL-4 diffuse large B-cell lymphoma cells treated with 17-DMAG, as evaluated by MTT assay and flow cytometry analysis. Apoptosis-associated protein levels were assessed using western blotting, and the results indicated that B-cell lymphoma 2 (Bcl-2)-associated protein X (Bax) was upregulated, whereas heat shock protein family A member 5 (HSPA5) and Bcl-2 were downregulated...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042932/cardioprotective-effect-of-notch-signaling-on-the-development-of-myocardial-infarction-complicated-by-diabetes-mellitus
#3
Fang Wu, Bo Yu, Xu Zhang, Yuelan Zhang
The present study aimed to elucidate the role of Notch signaling in the development of myocardial infarction (MI) concomitant with diabetes in vivo and in vitro and evaluated the therapeutic effect of the Notch signaling in vitro. Streptozotocin-induced diabetic rats were subjected to 25 min of ischemia and 2 h of reperfusion. Cardiac troponin T (cTnT) and creatine kinase-MB (CK-MB) isoenzyme levels were detected. Infarct size was measured by 2,3,5-triphenyltetrazolium chloride staining. Myocardial apoptosis and fibrosis were examined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling and Masson Trichrome staining, respectively...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042557/mechanocaloric-effects-in-superionic-thin-films-from-atomistic-simulations
#4
Arun K Sagotra, Daniel Errandonea, Claudio Cazorla
Solid-state cooling is an energy-efficient and scalable refrigeration technology that exploits the adiabatic variation of a crystalline order parameter under an external field (electric, magnetic, or mechanic). The mechanocaloric effect bears one of the greatest cooling potentials in terms of energy efficiency owing to its large available latent heat. Here we show that giant mechanocaloric effects occur in thin films of well-known families of fast-ion conductors, namely Li-rich (Li3OCl) and type-I (AgI), an abundant class of materials that routinely are employed in electrochemistry cells...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29040664/coumestrol-induces-mitochondrial-dysfunction-by-stimulating-ros-production-and-calcium-ion-influx-into-mitochondria-in-human-placental-choriocarcinoma-cells
#5
Whasun Lim, Changwon Yang, Muhah Jeong, Fuller W Bazer, Gwonhwa Song
STUDY QUESTION: Does coumestrol inhibit proliferation of human placental choriocarcinoma cells? SUMMARY ANSWER: Coumestrol promotes cell death in the choriocarcinoma cells by regulating ERK1/2 MAPK and JNK MAPK signaling pathways and through disruption of Ca2+ and ROS homeostasis. WHAT IS KNOWN ALREADY: A number of patients who suffer from choriocarcinomas fail to survive due to delayed diagnosis or a recurrent tumor and resistance to traditional chemotherapy using platinum-based agents and methotrexate...
October 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29039964/probing-linewidths-and-biexciton-quantum-yields-of-single-cesium-lead-halide-nanocrystals-in-solution
#6
Hendrik Utzat, Katherine E Shulenberger, Odin B Achorn, Michel Nasilowski, Timothy S Sinclair, Moungi G Bawendi
Cesium lead halide (CsPbX3, X = Cl, Br, I) perovskite nanocrystals (PNCs) have recently become a promising material for optoelectronic applications due to their high emission quantum yields and facile band gap tunability via both halide composition and size. The spectroscopy of single PNCs enhances our understanding of the effect of confinement on excitations in PNCs in the absence of obfuscating ensemble averaging and can also inform synthetic efforts. However, single PNC studies have been hampered by poor PNC photostability under confocal excitation, precluding interrogation of all but the most stable PNCs, leading to a lack of understanding of PNCs in the regime of high confinement...
October 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/29039948/photoassisted-homocoupling-of-methyl-iodide-mediated-by-atomic-gold-in-low-temperature-neon-matrix
#7
Satoru Muramatsu, Xuan Wu, Mohua Chen, Mingfei Zhou, Tatsuya Tsukuda
Infrared spectroscopy and density functional theory calculations showed that gold complexes [CH3-Au-I] and [(CH3)2-Au-I2], in which one and two CH3I molecule(s), respectively, are oxidatively adsorbed on the Au atoms, are formed in a solid neon matrix via the reactions between the laser-ablated gold atoms (Au) and methyl iodide (CH3I). Global reaction route mapping calculations revealed that the heights of the activation barriers for the sequential oxidative addition to produce [CH3-Au-I] and [(CH3)2-Au-I2] are 0...
October 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29039593/hyperthermia-with-different-temperatures-inhibits-proliferation-and-promotes-apoptosis-through-the-egfr-stat3-pathway-in-c6-rat-glioma-cells
#8
Yao-Dong Chen, Yu Zhang, Tian-Xiu Dong, Yu-Tong Xu, Wei Zhang, Ting-Ting An, Peng-Fei Liu, Xiu-Hua Yang
Malignant gliomas are a group of aggressive neoplasms among human cancers. The curative effects of current treatments are finite for improving the prognosis of patients. Hyperthermia (HT) is an effective treatment for cancers; however, the effects of HT with different temperatures in treatment of MG and relevant mechanisms remain unclear. MTT assay and Annexin V‑fluorescein isothiocyanate/propidium iodide staining were used for investigating the proliferation and apoptosis of C6 cells, respectively. Western blotting was applied to detect the expression of proteins...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039582/curcumol-inhibits-the-proliferation-of-gastric-adenocarcinoma-mgc-803-cells-via-downregulation-of-idh1
#9
Shilei Zang, Qiling Tang, Fangrui Dong, Huan Liu, Lili Li, Fang Guo, Xuediao Pan, Haorong Lin, Weibin Zeng, Zhaoxu Cai, Qibin Zhong, Ning Zang, Linquan Zang
Curcumol, a polyphenol compound derived from the rhizome of Curcuma, has been established as an antitumor compound against multiple types of cancer, including gastric (GC), lung, liver and breast cancer. However, the molecular mechanisms undelying its anticancer activity in GC are still unclear. In this study, the antitumor efficacy of curcumol was ascertained in human gastric adenocarcinoma MGC-803 cells. An MTT assay was used to assess the viability of the MGC-803 cells treated by curcumol. The results of the Annexin V/propidium iodide (PI) staining followed by fluorescence activated cell sorting (FACS) analysis demonstrated that the cell cycle was arrested in the G2/M phase by curcumol...
October 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039361/characterization-of-highly-crystalline-lead-iodide-nanosheets-prepared-by-room-temperature-solution-processing
#10
Riccardo Frisenda, Joshua O Island, Jose L Lado, Emerson Giovanelli, Patricia Gant, Philipp Nagler, Sebastian Bange, John M Lupton, Christian Schüller, Aday J Molina-Mendoza, Lucia Aballe, Michael Foerster, Tobias Korn, Miguel Angel Niño, David Perez de Lara, Emilio M Pérez, Joaquín Fernandéz-Rossier, Andres Castellanos-Gomez
Two-dimensional (2D) semiconducting materials are particularly appealing for many applications. Although theory predicts a large number of 2D materials, experimentally only a few of these materials have been identified and characterized comprehensively in the ultrathin limit. Lead iodide, which belongs to the transition metal halides family and has a direct bandgap in the visible spectrum, has been known for a long time and has been well characterized in its bulk form. Nevertheless, studies of this material in the nanometer thickness regime are rather scarce...
October 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29039355/highly-stable-cesium-lead-iodide-perovskite-quantum-dot-light-emitting-diodes
#11
Chen Zou, Chun-Ying Huang, Erin M Sanehira, Joseph M Luther, Lih Y Lin
Recently, all-inorganic perovskites such as CsPbBr3 and CsPbI3, have emerged as promising materials for light-emitting applications. While encouraging performance has been demonstrated, the stability issue of the red-emitting CsPbI3 is still a major concern due to its small tolerance factor. Here we report a highly stable CsPbI3 quantum dot (QD) light-emitting diode (LED) with red emission fabricated using an improved purification approach. The device achieved decent external quantum efficiency (EQE) of 0.21% at a bias of 6 V and outstanding operational stability, with a L 70 lifetime (EL intensity decreases to 70% of starting value) of 16 h and 1...
October 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29035550/copper-catalyzed-c-sp-2-s-coupling-reactions-for-the-synthesis-of-aryl-dithiocarbamates-with-thiuram-disulfide-reagents
#12
Zhi-Bing Dong, Xing Liu, Carsten Bolm
An efficient protocol for the copper-catalyzed preparation of aryl dithiocarbamates from aryl iodides and inexpensive, environmentally benign tetraalkylthiuram disulfides was developed. The features of mild reaction conditions, high yields, and broad substrate scope render this new approach synthetically attractive for the preparation of potentially biologically active compounds.
October 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/29033584/dna-ploidy-and-s-phase-fraction-analysis-in-peritoneal-carcinomatosis-from-ovarian-cancer-correlation-with-clinical-pathological-factors-and-response-to-chemotherapy
#13
Silvia Carloni, Giulia Gallerani, Anna Tesei, Emanuela Scarpi, Giorgio Maria Verdecchia, Salvatore Virzì, Francesco Fabbri, Chiara Arienti
OBJECTIVE: We investigated the correlation between ploidy or S-phase fraction (SPF) and the clinical pathological characteristics of patients with peritoneal carcinomatosis from ovarian cancer. We also assessed their relation with the in vivo and in vitro response to several chemotherapeutic agents. PATIENTS AND METHODS: Fifty-three patients with peritoneal carcinomatosis from ovarian cancer were enrolled. Frozen tumor tissue was dissociated by a detergent-trypsin method, and the resulting cell suspension was stained with RNase A and propidium iodide...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29032724/reintroducing-the-sodium-iodide-symporter-nis-to-anaplastic-thyroid-carcinoma
#14
Kathrin Alexandra Schmohl, Patrick Dolp, Christina Schug, Kerstin Knoop, Kathrin Klutz, Nathalie Schwenk, Peter Bartenstein, Peter Jon Nelson, Manfred Ogris, Ernst Wagner, Christine Spitzweg
Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer, is unresponsive to radioiodide therapy. In the current study, we aimed to extend the diagnostic and therapeutic application of radioiodide beyond the treatment of differentiated thyroid cancer by targeting the functional sodium iodide symporter (NIS) to ATC. We employed nanoparticle vectors (polyplexes) based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG) and coupled to the synthetic peptide GE11 as an epidermal growth factor receptor (EGFR)-specific ligand in order to target a <i>NIS</i>-expressing plasmid (LPEI-PEG-GE11/NIS) to EGFR overexpressing human thyroid carcinoma cell lines...
October 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29031799/impact-of-humic-acid-on-the-photoreductive-degradation-of-perfluorooctane-sulfonate-pfos-by-uv-iodide-process
#15
Zhuyu Sun, Chaojie Zhang, Pei Chen, Qi Zhou, Michael R Hoffmann
Iodide photolysis under UV illumination affords an effective method to produce hydrated electrons (eaq(-)) in aqueous solution. Therefore, UV/Iodide photolysis can be utilized for the reductive degradation of many recalcitrant pollutants. However, the effect of naturally occurring organic matter (NOM) such as humic and fulvic acids (HA/FA), which may impact the efficiency of UV/Iodide photoreduction, is poorly understood. In this study, the UV photoreductive degradation of perfluorooctane sulfonate (PFOS) in the presence of I(-) and HA is studied...
October 6, 2017: Water Research
https://www.readbyqxmd.com/read/29031292/a-new-integrated-tlc-mu-atr-sers-advanced-approach-for-the-identification-of-trace-amounts-of-dyes-in-mixtures
#16
Giorgia Sciutto, Silvia Prati, Irene Bonacini, Lucio Litti, Moreno Meneghetti, Rocco Mazzeo
The present research is focused on the setting up of an advanced analytical system for the detection of synthetic dyes. The system is based on the combination of an innovative thin layer chromatography (TLC) plate coupled with enhanced infrared (MU-ATR, metal underlayer attenuated total reflection) and Surface Enhanced Raman (SERS) spectroscopy. In particular, a TLC plate made of silver iodide (AgI) applied onto a gold coated glass slide (AgI@Au) is proposed as an efficient stationary phase for the separation of dyes mixtures...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29031204/ginkgetin-inhibits-growth-of-breast-carcinoma-via-regulating-mapks-pathway
#17
Jun Cao, Chuang Tong, Yanyan Liu, Jianguo Wang, Xiaoyan Ni, Mao-Ming Xiong
The purpose of present study was to investigate anti-tumor activity of Ginkgetin (GK) and its mechanism of action in breast cancer. The effects of GK on growth of human breast cancer cell lines MDA-MB-231, BT-474 and MCF-7 were examined by MTT assay. Cells apoptosis in MCF-7 cells were analyzed by TUNEL staining and annexin-V and propidium iodide double staining. The effects of GK on expression of apoptotic associated proteins and mitogen-activated protein kinases (MAPKs) were determined by western blotting...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030621/flow-cytometry-as-a-rapid-analytical-tool-to-determine-physiological-responses-to-changing-o2-and-iron-concentration-by-magnetospirillum-gryphiswaldense-strain-msr-1
#18
Alfred Fernández-Castané, Hong Li, Owen R T Thomas, Tim W Overton
Magnetotactic bacteria (MTB) are a diverse group of bacteria that synthesise magnetosomes, magnetic membrane-bound nanoparticles that have a variety of diagnostic, clinical and biotechnological applications. We present the development of rapid methods using flow cytometry to characterize several aspects of the physiology of the commonly-used MTB Magnetospirillum gryphiswaldense MSR-1. Flow cytometry is an optical technique that rapidly measures characteristics of individual bacteria within a culture, thereby allowing determination of population heterogeneity and also permitting direct analysis of bacteria...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030306/electrospraying-of-microfluidic-encapsulated-cells-for-the-fabrication-of-cell-laden-electrospun-hybrid-tissue-constructs
#19
L Weidenbacher, A Abrishamkar, M Rottmar, A G Guex, K Maniura-Weber, A J deMello, S J Ferguson, R M Rossi, G Fortunato
The fabrication of functional 3D tissues is a major goal in tissue engineering. While electrospinning is a promising technique to manufacture a structure mimicking the extracellular matrix, cell infiltration into electrospun scaffolds remains challenging. The robust and in situ delivery of cells into such biomimetic scaffolds would potentially enable the design of tissue engineered constructs with spatial control over cellular distribution but often solvents employed in the spinning process are problematic due to their high cytotoxicity...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29029371/structures-of-a-complex-hydrazinium-lead-iodide-n2h5-15pb3i21-possessing-pb2i9-5-pbi6-4-and-i-ions-and-%C3%AE-and-%C3%AE-n2h5-pbi3
#20
Joel S Miller, Eric Campbell, Brandon Dick, Arnold Rheingold, Chuang Zhang, Xiaojie Liu, Zeev Vardeny
Photovoltaic Perovskites, most notably methylammonium lead triiodide, (NH3Me)PbI3, have recently attracted considerable attention, and based upon the 'Goldschmidt Tolerance Factor' hydrazinium should be able to occupy the same cation site as methylammonium. The reaction of N2H5+I- with PbI2 in DMF results in three types of yellow crystals; hexagonal, needle-like, and rod-like, whose structures were determined at 100 K. The hexagonal [P63/m: a = 10.8906(10) Å; b = 37.845(5) Å] crystals possess isolated face sharing octahedral [Pb2I9]5-, [PbI6]4-, and I- ions...
October 13, 2017: Chemistry: a European Journal
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