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https://www.readbyqxmd.com/read/28939928/acute-heart-failure-an-unmet-medical-need
#1
REVIEW
A G Rigopoulos, C Bakogiannis, R de Vecchis, S Sakellaropoulos, M Ali, M Teren, M Matiakis, C Tschoepe, M Noutsias
Despite recent advances in the management of heart failure with reduced ejection fraction (HFrEF), the burden of acute heart failure (AHF) remains significant with a high morbidity and mortality that has not been improved by any treatment modality. A meta-analysis summarized the study results on the effects of tolvaptan on AHF, which failed to demonstrate an improvement in short-term and long-term mortality, length of hospital stay and reduced frequency of worsening heart failure (WHF). Similar trial results were also reported in other AHF studies, such as the ASCEND-HF and the RELAX-AHF-2 trials...
September 22, 2017: Herz
https://www.readbyqxmd.com/read/28937993/anaesthesia-not-number-of-sessions-influences-the-magnitude-and-duration-of-an-ahf-rtms-in-dogs
#2
Robrecht Dockx, Kathelijne Peremans, Lise Vlerick, Nick Van Laeken, Jimmy H Saunders, Ingeborgh Polis, Filip De Vos, Chris Baeken
BACKGROUND: Currently, the rat has been a useful animal model in brain stimulation research. Nevertheless, extrapolating results from rodent repetitive Transcranial Magnetic Stimulation (rTMS) research to humans contains several hurdles. This suggests the desperate need for a large animal model in translational rTMS research. The dog would be a valid choice, not only due to the fact that humans and dogs share a neurophysiological background, but a similar neuropathological background as well...
2017: PloS One
https://www.readbyqxmd.com/read/28933935/a-smartphone-application-to-reduce-time-to-notification-of-sexually-transmitted-infections
#3
Adam Carl Cohen, Frederick Zimmerman, Michael Prelip, Deborah Glik
OBJECTIVES: To measure whether the implementation of Healthvana-an online patient engagement platform and smartphone application-reduced the number of days between sexually transmitted infection (STI) testing, notification, and treatment at AIDS Healthcare Foundation (AHF) Wellness Centers. METHODS: We analyzed the retrospective data for 917 male clients who tested positive and received treatment for chlamydia, gonorrhea, or syphilis between January 1, 2014, and December 31, 2015...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28927169/c-reactive-protein-level-on-admission-and-time-to-and-cause-of-death-in-patients-hospitalized-for-acute-heart-failure
#4
Yuichiro Minami, Katsuya Kajimoto, Naoki Sato, Nobuhisa Hagiwara, Teruo Takano
Aims: We analysed the association between C-reactive protein (CRP) levels measured on admission and timing and cause of death among patients hospitalized for acute heart failure (AHF). Methods and Results: The ATTEND study prospectively registered 4777 hospitalized AHF patients with data on CRP levels on admission. Mortality risks were assessed by univariable and multivariable Cox proportional and non-proportional hazards models. The overall median CRP level was 5...
April 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28921054/association-of-mineralocorticoid-receptor-antagonist-use-and-in-hospital-outcomes-in-patients-with-acute-heart-failure
#5
Vasiliki Bistola, Panagiotis Simitsis, Dimitrios Farmakis, Ignatios Ikonomidis, Georgios Bakosis, Filippos Triposkiadis, Erifili Hatziagelaki, John Lekakis, Alexandre Mebazaa, John Parissis
Mineralocorticoid receptor antagonists (MRAs) constitute a beneficial therapy in chronic heart failure, but their use in the acute heart failure (AHF) setting remains rather unexplored. To assess the effect of MRAs administered during hospitalization on in-hospital outcomes of patients with AHF, we performed a post-hoc analysis of the Acute Heart Failure Global Registry of Standard Treatment (ALARM-HF). Patients of the original study cohort (n = 4953) were categorized according to in-hospital MRA treatment status as MRA-treated (n = 1439) and untreated (n = 3514) subjects...
September 18, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28891981/feasibility-of-serial-6-min-walk-tests-in-patients-with-acute-heart-failure
#6
Sean P Collins, Michael Thorn, Richard M Nowak, Phillip D Levy, Gregory J Fermann, Brian C Hiestand, Tillman Douglas Cowart, Robert P Venuti, William R Hiatt, ShiYin Foo, Peter S Pang
BACKGROUND: Functional status assessment is common in many cardiovascular diseases but it has undergone limited study in the setting of acute heart failure (AHF). Accordingly, we performed a pilot study of the feasibility of the six-minute walk test (6MWT) at the emergency department (ED) presentation and through the hospitalization in patients with AHF. METHODS AND RESULTS: From November 2014 to February 2015, we conducted a multicenter, observational study of ED patients, aged 18-85 years, whose primary ED admission diagnosis was AHF...
September 11, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28874293/a-plea-for-an-early-ultrasound-clinical-integrated-approach-in-patients-with-acute-heart-failure-a-proactive-comment-on-the-esc-guidelines-on-heart-failure-2016
#7
G Tavazzi, A N Neskovic, A Hussain, G Volpicelli, G Via
BACKGROUND: The European Association of Cardiology (ESC) Guidelines on the diagnosis and treatment of acute heart failure (AHF) indicate prompt therapy initiation and performance of relevant investigations as paramount. Specifically, echocardiography prior to treatment is advocated only with hemodynamic instability, and the evaluation of clinical signs of peripheral perfusion and congestion is suggested as guidance for early interventions. Given the growing body of evidence on the diagnostic/monitoring capabilities of bedside ultrasound (including focused cardiac ultrasound, comprehensive echocardiography, lung ultrasound), we discuss the potential benefit of an integrated clinical/ultrasound approach at the very early stages of acute heart failure...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28871820/acute-heart-failure-presentations-and-outcomes-during-the-fasting-month-of-ramadan-an-observational-report-from-seven-middle-eastern-countries
#8
Amar M Salam, Kadhim Sulaiman, Alawi A Alsheikh-Ali, Rajvir Singh, Nidal Asaad, Awad Al-Qahtani, Imtiaz Salim, Khalid F AlHabib, Ibrahim Al-Zakwani, Mohammed Al-Jarallah, Wael AlMahmeed, Bassam Bulbanat, Mustafa Ridha, Nooshin Bazargani, Haitham Amin, Ahmed Al-Motarreb, Husam AlFaleh, Hanan Albackr, Prashanth Panduranga, Abdulla Shehab, Jassim Al Suwaidi
BACKGROUND: Fasting during the month of Ramadan is practiced by over one and a half billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic dimensions. We examined the effects of fasting in patients with acute heart failure (AHF) using data from a large multi-center heart failure registry. METHODS AND RESULTS: Data were derived from Gulf CARE (Gulf aCute heArt failuRe rEgistry), a prospective multicenter study of consecutive patients hospitalized with AHF during February-November 2012...
September 5, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28871621/systolic-blood-pressure-reduction-during-the-first-24%C3%A2-h-in-acute-heart-failure-admission-friend-or-foe
#9
Gad Cotter, Marco Metra, Beth A Davison, Guillaume Jondeau, John G F Cleland, Robert C Bourge, Olga Milo, Christopher M O'Connor, John D Parker, Guillermo Torre-Amione, Dirk J van Veldhuisen, Isaac Kobrin, Maurizio Rainisio, Stefanie Senger, Christopher Edwards, John J V McMurray, John R Teerlink
AIMS: Changes in systolic blood pressure (SBP) during an admission for acute heart failure (AHF), especially those leading to hypotension, have been suggested to increase the risk for adverse outcomes. METHODS AND RESULTS: We analysed associations of SBP decrease during the first 24 h from randomization with serum creatinine changes at the last time-point available (72 h), using linear regression, and with 30- and 180-day outcomes, using Cox regression, in 1257 patients in the VERITAS study...
September 4, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28865801/approach-to-acute-heart-failure-in-the-emergency-department
#10
REVIEW
Benton R Hunter, Jennifer Martindale, Osama Abdel-Hafez, Peter S Pang
Acute heart failure (AHF) patients rarely present complaining of 'acute heart failure.' Rather, they initially present to the emergency department (ED) with a myriad of chief complaints, symptoms, and physical exam findings. Such heterogeneity prompts an initially broad differential diagnosis; securing the correct diagnosis can be challenging. Although AHF may be the ultimate diagnosis, the precipitant of decompensation must also be sought and addressed. For those AHF patients who present in respiratory or circulatory failure requiring immediate stabilization, treatment begins even while the diagnosis is uncertain...
August 30, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28865437/the-top-tertile-of-hematocrit-change-during-hospitalization-is-associated-with-lower-risk-of-mortality-in-acute-heart-failure-patients
#11
Haobin Zhou, Tianyu Xu, Yuli Huang, Qiong Zhan, Xingfu Huang, Qingchun Zeng, Dingli Xu
BACKGROUND: Hemoconcentration has been proposed as surrogate for changes in volume status among patients hospitalized with acute heart failure (AHF) and is associated with a favorable outcome. However, there is a dearth of research assessing the clinical outcomes of hospitalized patients with hemoconcentration, hemodilution and unchanged volume status. METHODS: We enrolled 510 consecutive patients hospitalized for AHF from April 2011 to July 2015. Hematocrit (HCT) levels were measured at admission and either at discharge or on approximately the seventh day of admission...
September 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28862951/serum-neprilysin-and-recurrent-admissions-in-patients-with-heart-failure
#12
Julio Núñez, Eduardo Núñez, Jaume Barallat, Vicent Bodí, Gema Miñana, M Cruz Pastor, Juan Sanchis, Josep Lupón, Antoni Bayes-Genis
BACKGROUND: Our aim was to evaluate the association between the soluble form of neprilysin (sNEP) levels and long-term all-cause, cardiovascular, and acute heart failure (AHF) recurrent admissions in an ambulatory cohort of patients with heart failure. sNEP has emerged as a new biomarker with promising implications for prognosis and therapy in patients with heart failure. Reducing the recurrent admission rate of heart failure patients has become an important target of public health planning strategies...
August 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28857829/were-we-prepared-for-prep-five-years-of-implementation
#13
Michael Weinstein, Otto O Yang, Adam Carl Cohen
: While the overall incidence of HIV infections in the United States (US) has decreased in recent years, certain populations remain particularly vulnerable, including racial/ethnic minorities, adolescents/young adults, and people in the southern US [1]. The Centers for Disease Control and Prevention (CDC) stated strategy to combat new infections includes a combination of "cost-effective, scalable interventions based on current science" [2]. In July 2012, the US Food and Drug Administration (FDA) approved daily oral combination tenofovir/emtricitabine ("Truvada") for pre-exposure prophylaxis (PrEP) in at-risk uninfected adults, with subsequent endorsement as blanket policy by the CDC in May 2014 [3]...
August 28, 2017: AIDS
https://www.readbyqxmd.com/read/28851237/-she-gave-me-the-confidence-to-open-up-bridging-communication-by-promotoras-in-a-childhood-obesity-intervention-for-latino-families
#14
Jennifer Falbe, Lily E Friedman, Karen Sokal-Gutierrez, Hannah R Thompson, Nicole K Tantoco, Kristine A Madsen
Childhood obesity is a public health threat that disproportionally affects Latino youth in the United States. Active and Healthy Families (AHF) is a culturally tailored, family-based program for addressing obesity disparities in a predominantly immigrant Latino population. AHF was the first primary care, culturally tailored intervention for Latino children to significantly reduce BMI in a randomized controlled trial. The 10-week AHF intervention reduced BMI (kg/m(2)) among overweight or obese children by 0...
August 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28836728/relax-ahf-blast-ahf-true-ahf-and-other-important-truths-in-acute-heart-failure-research
#15
EDITORIAL
Gad Cotter, Alain Cohen-Solal, Beth A Davison, Alexandre Mebazaa
No abstract text is available yet for this article.
August 24, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28831592/a-comparative-study-of-intraoperative-findings-and-postoperative-outcomes-between-atypical-and-typical-hemifacial-spasms
#16
MingXing Liu, Lei Xia, Jun Zhong, Bin Li, NingNing Dou, ShiTing Li
In most hemifacial spasm cases, the spasm initiates from the orbicularis occuli muscle and gradually spreads downwards to the orbicularis oris and buccinator muscles. Seldomly, the spasm might start from the orbicularis oris and buccinator muscles and develop upwards, which has been called as atypical hemifacial spasm (aHFS). Until now, little is known about its pathogenesis and the efficacy of microvascular decompression (MVD) surgery. We reviewed 1935 HFS cases undergoing MVD between 2007 through 2016. Among them, 15 were diagnosed as aHFS, whom were focused on...
August 22, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28826934/inotropes-and-cardiorenal-syndrome-in-acute-heart-failure-a-retrospective-comparative-analysis
#17
Marta Madeira, Francisca Caetano, Inês Almeida, Andreia Fernandes, Liliana Reis, Marco Costa, Lino Gonçalves
INTRODUCTION: Cardiorenal syndrome (CRS) is common in acute heart failure (AHF), and is associated with dire prognosis. Levosimendan, a positive inotrope that also has diuretic effects, may improve patients' renal profile. Published results are conflicting. OBJECTIVES: We aimed to assess the incidence of CRS in AHF patients according to the inotrope used and to determine its predictors in order to identify patients who could benefit from the most renoprotective inotrope...
August 18, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28826838/interferon-%C3%AE-driven-inos-a-molecular-pathway-to-terminal-shock-in-arenavirus-hemorrhagic-fever
#18
Melissa M Remy, Mehmet Sahin, Lukas Flatz, Tommy Regen, Lifen Xu, Mario Kreutzfeldt, Benedict Fallet, Camille Doras, Toni Rieger, Lukas Bestmann, Uwe-Karsten Hanisch, Beat A Kaufmann, Doron Merkler, Daniel D Pinschewer
Arenaviruses such as Lassa virus (LASV) cause hemorrhagic fever. Terminal shock is associated with a systemic cytokine storm, but the mechanisms are ill defined. Here we used HLA-A2-expressing mice infected with a monkey-pathogenic strain of lymphocytic choriomeningitis virus (LCMV-WE), a close relative of LASV, to investigate the pathophysiology of arenavirus hemorrhagic fever (AHF). AHF manifested as pleural effusions, edematous skin swelling, and serum albumin loss, culminating in hypovolemic shock. A characteristic cytokine storm included numerous pro-inflammatory cytokines and nitric oxide (NO) metabolites...
September 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28820057/impact-of-angiotensin-converting-enzyme-inhibitors-angiotensin-receptors-blockers-on-mortality-in-acute-heart-failure-patients-with-left-ventricular-systolic-dysfunction-in-the-middle-east-observations-from-the-gulf-acute-heart-failure-registry-gulf-care
#19
Ibrahim Al-Zakwani, Kadhim Sulaiman, Jawad A Al-Lawati, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin
AIMS: To evaluate the impact of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptors blockers (ARBs) on in-hospital, 3- and 12-month all-cause mortality in acute heart failure (AHF) patients with left ventricular systolic dysfunction in 7 countries of the Middle East. METHODS AND RESULTS: Data was analysed from 2,683 consecutive patients admitted with AHF and low ventricular ejection fraction (LVEF) (<40%) from 47 hospitals from February to November, 2012...
August 17, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28807403/prevalence-of-hyperuricemia-in-patients-with-acute-heart-failure-with-either-reduced-or-preserved-ejection-fraction
#20
RANDOMIZED CONTROLLED TRIAL
Alberto Palazzuoli, Gaetano Ruocco, Oreste De Vivo, Ranuccio Nuti, Peter A McCullough
The relation between uric acid (UA) and heart failure has been described; however, there is little detail concerning acute heart failure (AHF) in patients with reduced versus preserved ejection fraction heart failure (HFrEF, HFpEF). We studied 324 consecutive AHF patients screened from interventional Diur-HF Trial (NCT01441245) from January 2011 to February 2016, and divided into HFrEF (EF <50%) and HFpEF (EF ≥50%). We defined hyperuricemia as serum UA ≥7.0 mg/dL in men and ≥6 mg/dL in women. Patients were followed up for 6 months after discharge...
October 1, 2017: American Journal of Cardiology
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