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https://www.readbyqxmd.com/read/27914667/high-sensitivity-troponin-t-and-the-risk-of-recurrent-readmissions-after-hospitalisation-for-acute-heart-failure
#1
D Escribano, E Santas, G Miñana, A Mollar, S García-Blas, E Valero, A Payá, F J Chorro, J Sanchis, J Núñez
OBJECTIVES: High-sensitivity troponin is a biomarker of myocardial damage and is associated with a greater risk of mortality and disease progression in patients with acute heart failure (AHF). However, its relationship with the risk of future readmissions is less known. The aim of this study was to assess the association between ultrasensitive troponin T (TnT-us) values in patients with AHF and the risk of recurrent readmissions in the follow-up. METHODS: We prospectively included a cohort of 621 consecutive patients with AHF, excluding those patients with acute coronary syndrome...
November 30, 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/27912923/predictors-of-30-day-mortality-in-patients-admitted-to-emergency-departments-for-acute-heart-failure
#2
Matthieu Marchetti, Antoine Benedetti, Olivier Mimoz, Jean-Yves Lardeur, Jérémy Guenezan, Nicolas Marjanovic
OBJECTIVES: Acute heart failure (AHF) is a leading cause of admission in emergency departments (ED). It is associated with significant in-hospital mortality, suggesting that there is room for improvement of care. Our aims were to investigate clinical patterns, biological characteristics and determinants of 30-day mortality. METHODS: We conducted a single site, retrospective review of adult patients (≥18years) admitted to ED for AHF over a 12-month period. Data collected included demographics, clinical, biological and outcomes data...
November 22, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27912902/evolution-of-the-clinical-profile-of-patients-with-acute-heart-failure-treated-in-spanish-emergency-departments
#3
R Escoda, Ò Miró, F J Martín-Sánchez, J Jacob, P Herrero, V Gil, J M Garrido, M J Pérez-Durá, M Fuentes, P Llorens
OBJECTIVE: To analyse the changes in epidemiology, outpatient and emergency department clinical care, and outcomes of patients treated for acute heart failure (AHF) in Spanish hospital emergency departments (HEDs) between 2007 and 2014. METHOD: A multicentre cohort study was conducted that consecutively included patients with AHF diagnosed in 9HEDs during 4 periods (2007, 2009, 2011 and 2014). The study analysed the changes observed in 20 variables corresponding to baseline data, outpatient care and emergency care data and outcome data...
November 29, 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/27908391/prevalence-profile-and-prognosis-of-severe-obesity-in-contemporary-hospitalized-heart-failure-trial-populations
#4
Emer Joyce, Anuradha Lala, Susanna R Stevens, Lauren B Cooper, Omar F AbouEzzeddine, John D Groarke, Justin L Grodin, Eugene Braunwald, Kevin J Anstrom, Margaret M Redfield, Lynne W Stevenson
OBJECTIVES: This study evaluated the prevalence, profile, and prognosis of severe obesity in a large contemporary acute heart failure (AHF) population. BACKGROUND: Better prognosis has been reported for obese heart failure (HF) patients than nonobese HF patients, but in other cardiovascular populations, this effect has not been demonstrated for severely obese patients. METHODS: A cohort of 795 participants with body mass index (BMI) measured at time of admission and complete follow-up were identified from enrollment in 3 contemporary AHF trials (DOSE [Diuretic Strategies Optimization Evaluation], CARRESS-HF [Cardiorenal Rescue Study in Acute Decompensated Heart Failure], and ROSE [Renal Optimization Strategies Evaluation in Acute Heart Failure])...
December 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27891443/a-randomized-prospective-study-of-concurrent-chemo-radiotherapy-vs-accelerated-hyperfractionation-in-advanced-cancer-of-head-and-neck
#5
Himanshu Mishra, Ritusha Mishra, Uday Prataap Shahi, Abhijit Mandal
INTRODUCTION: Locally advanced unresectable squamous cell carcinoma of head and neck has poor locoregional control when treated with conventionally fractionated Radiation Therapy (RT) alone. However, Concurrent Chemo-Radiotherapy (CRT) and altered fractionated RT schedules like Accelerated Hyperfractionation (AHF) are two different treatment strategies that have shown to be associated with better efficacy as compared to conventional RT alone in such cases. AIM: Aim of the study was to compare these two treatment strategies i...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27883979/low-nt-probnp-levels-an-early-sign-for-the-diagnosis-of-ischemic-heart-failure
#6
Ya-Ru Zheng, Li-Fang Ye, Xue-Jiang Cen, Jing-Yang Lin, Jian-Wei Fu, Li-Hong Wang
BACKGROUND: N-terminal pro-brain natriuretic peptide (NT-proBNP) is seen to be mostly elevated in patients with acute heart failure (AHF). However, cases of AHF presenting with low NT-proBNP levels have been reported. In this study designed to investigate the factors associated with low NT-proBNP levels in AHF patients, we discovered that etiology and related factors have an influence on NT-proBNP levels. METHODS: In this study, 154 AHF patients met the study criteria (117 men, median age 74years; left ventricular ejection fraction [LVEF] 46±13%; New York Heart Association [NYHA] classes II-IV)...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27879165/eahfe-tropica2-study-prognostic-value-of-troponin-in-patients-with-acute-heart-failure-treated-in-spanish-hospital-emergency-departments
#7
Javier Jacob, Alex Roset, Òscar Miró, Aitor Alquézar, Pablo Herrero, Francisco Javier Martín-Sanchez, Martin Möckel, Christian Müller, Pere Llorens
OBJECTIVE: Evaluate the use of different cardiac troponin (cTn) immunoassays and the prognostic value of increased cTn values in patients diagnosed with acute heart failure (AHF) in the emergency department (ED). METHOD: The EAHFE-TROPICA2 is a retrospective study including patients with AHF admitted in 34 Spanish EDs with cTn values determined in the ED. We studied the prevalence of elevated troponin (value above the established reference limit) for the different types of troponin...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27875723/orosomucoid-as-prognosis-factor-associated-with-inflammation-in-acute-or-nutritional-status-in-chronic-heart-failure
#8
Rosa M Agra, Alfonso Varela-Román, Rocío González-Ferreiro, Juan E Viñuela, Ana Castro-Pais, Ángel Fernández-Trasancos, Esther Díaz-Rodríguez, Ezequiel Álvarez, Marcos C Carreira, Felipe F Casanueva, José R González-Juanatey, Sonia Eiras
BACKGROUND: Inflammation and nutritional state are involved in the pathogenesis of heart failure (HF). OBJECTIVE: To study the contribution of alpha-1-acid-glycoprotein (AGP) to these factors and its prognostic value in acute (AHF) or chronic HF (CHF). METHODS: The observational study has included 147 patients (mean age 70years, 62% men) admitted to a cardiology department for HF and followed-up for an average 326.6±140.8days. Blood AGP values were measured by Enzyme-Linked ImmunoSorbent Assay...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27866869/clinical-characteristics-and-outcomes-of-yemeni-patients-with-acute-heart-failure-aged-50years-or-younger-data-from-gulf-acute-heart-failure-registry-gulf-care
#9
A-Nasser Munibari, Ahmed Al-Motarreb, Nora Al-Sagheer, Hana Abu Hadi, Ali Othman, Nawar Al-Wather, Abdu Hamoud, Mutae Alawlagy, Salem Almehdar, Abdulkarim Alhammadi, Mohammed Almogayed, Giorgio Caretta, Anees Al Jabri, Luciano Agati
AIMS: There is a shortage of data about acute heart failure (AHF) in the young, including its underlying causes, clinical presentation and outcomes. We aim to describe clinical characteristics, causes and outcomes of AHF in Yemeni patients aged 50years or younger. METHODS AND RESULTS: we evaluated Yemeni patients with AHF enrolled in Gulf CARE registry. Patients were divided into two groups: young patients (≤50years) and older patients (>50years). A total of 1536 patients with AHF were enrolled, of whom 635 (41...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27862700/rationale-for-and-design-of-the-true-ahf-trial-the-effects-of-ularitide-on-the-short-term-clinical-course-and-long-term-mortality-of-patients-with-acute-heart-failure
#10
Milton Packer, Richard Holcomb, William T Abraham, Stefan Anker, Kenneth Dickstein, Gerasimos Filippatos, Henry Krum, Aldo P Maggioni, John J V McMurray, Alexandre Mebazaa, Christopher O'Connor, Frank Peacock, Piotr Ponikowski, Frank Ruschitzka, Dirk J van Veldhuisen, Johannes Holzmeister
: The TRUE-AHF is a randomized, double-blind, parallel-group, placebo-controlled trial which is evaluating the effects of a 48-h infusion of ularitide (15 ng/kg/min) on the short- and long-term clinical course of patients with acute heart failure. Noteworthy features of the study include the early enrolment of patients following their initial clinical presentation (within 12 h), and entry blood pressure criteria and thresholds for the adjustment of drug infusion rates, which aim to minimize the risk of hypotension...
November 13, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27825893/evaluating-the-efficacy-safety-and-tolerability-of-serelaxin-when-added-to-standard-therapy-in-asian-patients-with-acute-heart-failure-the-design-and-rationale-of-relax-ahf-asia-trial
#11
Naoki Sato, Carolyn S P Lam, John R Teerlink, Barry H Greenberg, Hiroyuki Tsutsui, Byung-Hee Oh, Jian Zhang, Martin Lefkowitz, Tsushung A Hua, Thomas Holbro, Miriam Marshood, Xing Li Wang, Junbo Ge
BACKGROUND: Acute heart failure (AHF), a common and growing health-concern worldwide, is associated with high risk of post-discharge rehospitalization and mortality. Existing evidence indicates potential therapeutic benefits of serelaxin in Caucasian AHF patients, while corresponding data in Asians remain scarce. RELAX-AHF-ASIA, a multinational, randomized, double-blind, placebo-controlled, phase-III trial, will evaluate the effects of serelaxin on symptom relief and clinical outcomes in Asian AHF patients, using novel assessments...
November 4, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27825693/use-of-nitroglycerin-by-bolus-prevents-intensive-care-unit-admission-in-patients-with-acute-hypertensive-heart-failure
#12
Suprat Saely Wilson, Gregory M Kwiatkowski, Scott R Millis, John D Purakal, Arushi P Mahajan, Phillip D Levy
OBJECTIVES: The purpose of this study was to compare health care resource utilization among patients who were given intravenous nitroglycerin for acute heart failure (AHF) in the emergency department (ED) by intermittent bolus, continuous infusion, or a combination of both. METHODS: We retrospectively identified 395 patients that received nitroglycerin therapy in the ED for the treatment of AHF over a 5-year period. Patients that received intermittent bolus (n=124) were compared with continuous infusion therapy (n=182) and combination therapy of bolus and infusion (n=89)...
October 18, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27823598/serum-potassium-levels-and-outcome-in-acute-heart-failure-data-from-the-protect-and-coach-trials
#13
Jasper Tromp, Jozine M Ter Maaten, Kevin Damman, Christopher M O'Connor, Marco Metra, Howard C Dittrich, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G F Cleland, Michael M Givertz, Daniel M Bloomfield, Martje H L van der Wal, Tiny Jaarsma, Dirk J van Veldhuisen, Hans L Hillege, Adriaan A Voors, Peter van der Meer
Serum potassium is routinely measured at admission for acute heart failure (AHF), but information on association with clinical variables and prognosis is limited. Potassium measurements at admission were available in 1,867 patients with AHF in the original cohort of 2,033 patients included in the Patients Hospitalized with acute heart failure and Volume Overload to Assess Treatment Effect on Congestion and Renal FuncTion trial. Patients were grouped according to low potassium (<3.5 mEq/l), normal potassium (3...
October 8, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27818784/red-cell-distribution-width-and-mortality-in-acute-heart-failure-patients-with-preserved-and-reduced-ejection-fraction
#14
Konstantinos Sotiropoulos, Patrick Yerly, Pierre Monney, Antoine Garnier, Julien Regamey, Olivier Hugli, David Martin, Melanie Metrich, Jean-Philippe Antonietti, Roger Hullin
BACKGROUND: Elevated red blood cell distribution width (RDW) is a valid predictor of outcome in acute heart failure (AHF). It is unknown whether elevated RDW remains predictive in AHF patients with either preserved left ventricular ejection fraction (LVEF) ≥50% or reduced LVEF (<50%). METHODS AND RESULTS: Prospective local registry including 402 consecutive hospitalized AHF patients without acute coronary syndrome or need of intensive care. The primary outcome was all-cause mortality (ACM) at 1 year after admission...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27818780/acute-heart-failure-facts-and-numbers-acute-heart-failure-populations
#15
EDITORIAL
Julia Searle, Johann Frick, Martin Möckel
Acute heart failure (AHF) is a life-threatening emergency, which largely profits from early diagnosis and treatment. The prevalence of AHF is difficult to assess, estimates range between 1 and 12% in the general population. Despite recent therapeutic advances, in-hospital mortality is high with estimates varying from 4 and 18% in different registries. Due to large differences in AHF definitions and selection criteria AHF populations vary in their characteristics and outcomes. This is especially true for randomized clinical trials and the external validity of some of these trials is questionable...
June 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27816115/implications-of-serum-chloride-homeostasis-in-acute-heart-failure-from-rose-ahf
#16
Justin L Grodin, Jie-Lena Sun, Kevin J Anstrom, Horng H Chen, Randall C Starling, Jeffrey M Testani, W H Wilson Tang
Lower serum chloride (Cl) levels are strongly associated with increased long-term mortality after admission for acute heart failure (AHF). However, the therapeutic implications of serum Cl levels during AHF are unknown. We sought to determine the short-term clinical response and postdischarge outcomes associated with serum Cl levels in AHF. Serum Cl was measured at randomization (n = 358) and during hospitalization from patients with AHF in the Renal Optimization Strategies Evaluation in Acute Heart Failure trial...
September 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27814267/systolic-blood-pressure-on-admission-and-mortality-in-patients-hospitalized-with-acute-heart-failure-observations-from-the-gulf-acute-heart-failure-registry
#17
Jawad A Al-Lawati, Kadhim J Sulaiman, Ibrahim Al-Zakwani, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F Al-Habib, Jassim Al-Suwaidi, Wael Al-Mahmeed, Hussam Al-Faleh, Abdelfatah El-Asfar, Ahmed Al-Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al-Jarallah, Nooshin Bazargani, Nidal Asaad, Haitham Amin
We investigated the role of systolic blood pressure (SBP) in relation to in-hospital and postdischarge mortality in patients admitted with acute heart failure (AHF). The SBP of 4848 patients aged ≥18 years admitted with AHF was categorized into 5 groups: ≤90, 91 to 119, 120 to 139, 140 to 161, and >161 mm Hg. After adjusting for several confounders, multivariate logistic regression models showed that admission SBP was a significant predictor of mortality among both patients with preserved left ventricular function (defined as left ventricular ejection fraction [LVEF] ≥40%) and patients with left ventricular dysfunction (LVEF <40%)...
October 7, 2016: Angiology
https://www.readbyqxmd.com/read/27812386/effect-of-precipitating-factors-of-acute-heart-failure-on-readmission-and-long-term-mortality
#18
Mattia Arrigo, Heli Tolppanen, Malha Sadoune, Elodie Feliot, Antonio Teixeira, Said Laribi, Patrick Plaisance, Semir Nouira, Mehmet Birhan Yilmaz, Etienne Gayat, Alexandre Mebazaa
AIMS: Acute heart failure (AHF) is one of the leading causes of unscheduled hospitalization and is associated with frequent readmissions and substantial mortality. Precipitating factors of AHF influence short-term mortality, but their effect on outcome after hospital discharge is unknown. The present study assessed the effect of precipitating factors on readmission and long-term survival in the overall population and in patients aged 75 years or younger. METHODS AND RESULTS: Patients admitted with AHF (n = 755) included in the multicentre cohort 'Biomarcoeurs' were included in the study...
June 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27810605/spontaneous-intracerebral-hemorrhage-in-hemophiliacs-a-treatment-dilemma
#19
Ajay Hegde, Rajesh Nair, Sunil Upadhyaya
BACKGROUND: Spontaneous Intracerebral hemorrhage is a rare and challenging condition to treat, especially in haemophiliacs. With their innate predilection to bleed following trivial trauma, surgical management of such cases have been individualised and no treatment protocols exist. Often they are managed with craniotomy and evacuation under cover of AHF. DISCUSSION: Here we discuss the nuances, clinical and treatment dilemma that one faces while treating a patient, diagnosed with haemophilia, with spontaneous subdural haematoma...
October 25, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27797432/the-effect-of-frailty-on-30-day-mortality-risk-in-older-patients-with-acute-heart-failure-attended-in-the-emergency-department
#20
Francisco Javier Martín-Sánchez, Esther Rodríguez-Adrada, Christian Mueller, M T Vidán, Michael Christ, W Frank Peacock, Miguel Alberto Rizzi, Aitor Alquezar, Pascual Piñera, Paula Lázaro Aragues, Pere Llorens, Pablo Herrero, Javier Jacob, Cristina Fernández, Òscar Miró
OBJECTIVE: To determine the effect of frailty on risk of 30-day mortality in non-severely disabled older patients with acute heart failure (AHF) attended in emergency departments (EDs). METHODOLOGY: The Frailty-AHF Study is a retrospective analysis of a multicentre, observational, prospective, cohort study (Older-AHF Register). This study included consecutive patients ≥ 65 years of age without severe functional dependence or dementia attended for AHF in 3 Spanish EDs during 4 months...
October 31, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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