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https://www.readbyqxmd.com/read/29337281/clinical-significance-of-early-fluid-and-weight-change-during-acute-heart-failure-hospitalization
#1
John D Groarke, Susanna R Stevens, Robert J Mentz, Lauren B Cooper, Justin M Vader, Omar F AbouEzzeddine, Justin L Grodin, Emer Joyce, Kevin J Anstrom, G Michael Felker, Margaret M Redfield, Lynne Warner Stevenson, Anuradha Lala
AIMS: To explore the association of changes in weight and fluid during treatment for acute heart failure (AHF) with clinical endpoints. METHODS AND RESULTS: Weight and net fluid changes recorded at 72-96 hours in 708 AHF patients enrolled in DOSE-HF, CARRESS-HF or ROSE-AHF, were compared to freedom from congestion at 72-96 hours and a composite end point of death, re-hospitalization, and unplanned hospital visit at 60 days. Weight loss was concordant with net fluid loss in 55%, discordant and less than expected for fluid loss in 34%, and paradoxically discordant or more than expected for fluid loss in 11% of patients...
January 11, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29329298/single-image-super-resolution-based-on-approximated-heaviside-functions-and-iterative-refinement
#2
Xin-Yu Wang, Ting-Zhu Huang, Liang-Jian Deng
One method of solving the single-image super-resolution problem is to use Heaviside functions. This has been done previously by making a binary classification of image components as "smooth" and "non-smooth", describing these with approximated Heaviside functions (AHFs), and iteration including l1 regularization. We now introduce a new method in which the binary classification of image components is extended to different degrees of smoothness and non-smoothness, these components being represented by various classes of AHFs...
2018: PloS One
https://www.readbyqxmd.com/read/29321797/prediction-model-of-in-hospital-mortality-in-elderly-patients-with-acute-heart-failure-based-on-retrospective-study
#3
Qian Jia, Yu-Rong Wang, Ping He, Xue-Liang Huang, Wei Yan, Yang Mu, Kun-Lun He, Ya-Ping Tian
Objectives: The aim of this study was to develop a clinical risk model that is predictive of in-hospital mortality in elderly patients hospitalized with acute heart failure (AHF). Methods: 2486 patients who were 60 years and older from intensive care units of Cardiology Department in the hospital were analyzed. Independent risk factors for in-hospital mortality were obtained by binary logistic regression and then used to establish the risk prediction score system (RPSS)...
November 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29315647/antiviral-activity-of-a771726-the-active-metabolite-of-leflunomide-against-jun%C3%A3-n-virus
#4
Claudia S Sepúlveda, Cybele C García, Elsa B Damonte
The aim of this study was to investigate the effect of A771726, the active metabolite of leflunomide, against the infection with Junín virus (JUNV), agent of Argentine hemorrhagic fever (AHF). The treatment with non-cytotoxic concentrations of A771726 of Vero and A549 cells infected with JUNV inhibited virus replication in a dose-dependent manner, as determined by virus yield reduction assay. The antiviral effectiveness of A771726 was not importantly affected by the multiplicity of infection and the virus strain...
January 5, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29310997/neurohormonal-imbalance-a-neglected-problem-and-potential-therapeutic-target-in-acute-heart-failure
#5
Steven R Goldsmith, Bradley A Bart, Ileana L Piña
Decompensated or acute heart failure (AHF) is characterized by increased ventricular and atrial pressures which may lead to and be caused by circulatory congestion. Unless due to a primary decrease in cardiac function, congestion arises from volume expansion or vasoconstriction. In turn, volume expansion and vasoconstriction are due to neurohormonal imbalance since both result from activation of the sympathetic nervous system, the renin-angiotensin-aldosterone axis and excess secretion of arginine vasopressin...
December 16, 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/29306479/site-enrollment-rate-outcomes-and-study-drug-effects-in-a-multicenter-trial-results-from-relax-ahf
#6
Marco Metra, Beth A Davison, Claudio Gimpelewicz, Valentina Carubelli, G Michael Felker, Gerasimos Filippatos, Barry H Greenberg, Tsushung A Hua, Zoe Liu, Peter S Pang, Piotr Ponikowski, Thomas M Severin, Adriaan A Voors, Yi Wang, Gad Cotter, John R Teerlink
BACKGROUND: Site selection is critical in acute heart failure trials. We assessed whether the enrollment rate per site affects patients' characteristics, outcomes and treatment response. METHODS AND RESULTS: A total of 1161 patients enrolled at 96 sites in the RELAX-AHF trial (serelaxin vs placebo) were included. Annualized enrollment rate was calculated as the total number of patients enrolled at each site divided by time that the site was open (patients per year)...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29304097/left-bundle-branch-block-in-duchenne-muscular-dystrophy-prevalence-genetic-relationship-and-prognosis
#7
Abdallah Fayssoil, Rabah Ben Yaou, Adam Ogna, Cendrine Chaffaut, France Leturcq, Olivier Nardi, Karim Wahbi, Denis Duboc, Frederic Lofaso, Helene Prigent, Bernard Clair, Pascal Crenn, Guillaume Nicolas, Pascal Laforet, Anthony Behin, Sylvie Chevret, David Orlikowski, Djillali Annane
BACKGROUND: Duchenne muscular dystrophy (DMD) is an inherited myogenic disorder due to mutations in the dystrophin gene on chromosome Xp21.1. We designed this study to determine the prevalence of left bundle branch block (LBBB), whether there is a relationship between LBBB and genetic pattern, and to assess predictive factors for acute cardiac events and mortality in adult DMD patients. METHODS: We reviewed the charts of DMD followed at the Home Mechanical Ventilation Unit of the Raymond Poincare University Hospital...
2018: PloS One
https://www.readbyqxmd.com/read/29287944/prediction-of-early-adverse-events-in-emergency-department-patients-with-acute-heart-failure-a-systematic-review
#8
REVIEW
Allison M Michaud, Shannon I A Parker, Heather Ganshorn, Justin A Ezekowitz, Andrew D McRae
BACKGROUND: Acute heart failure (AHF) accounts for a substantial proportion of Emergency Department (ED) visits and hospitalizations. Previous studies have shown that emergency physicians' clinical gestalt is not sufficient to stratify patients with AHF into severe and requiring hospitalization vs nonsevere and safe to be discharged. Various prognostic algorithms have been developed to risk-stratify patients with AHF, however there is no consensus as to the best-performing risk assessment tool in the ED...
September 12, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29285622/effects-of-the-intensity-of-prehospital-treatment-on-short-term-outcomes-in-patients-with-acute-heart-failure-the-semica-2-study
#9
Òscar Miró, Melissa Hazlitt, Xavier Escalada, Pere Llorens, Víctor Gil, Francisco Javier Martín-Sánchez, Pia Harjola, Verónica Rico, Pablo Herrero-Puente, Javier Jacob, David C Cone, Martin Möckel, Michael Christ, Yonathan Freund, Salvatore di Somma, Said Laribi, Alexandre Mebazaa, Veli-Pekka Harjola
OBJECTIVE: Little is known about treatments provided by advanced life support (ALS) ambulance teams to patients with acute heart failure (AHF) during the prehospital phase, and their influence on short-term outcome. We evaluated the effect of prehospital care in consecutive patients diagnosed with AHF in Spanish emergency departments (EDs). METHODS: We selected patients from the EAHFE registry arriving at the ED by ALS ambulances with available follow-up data. We recorded specific prehospital ALS treatments (supplemental oxygen, diuretics, nitroglycerin, non-invasive ventilation) and patients were grouped according to whether they received low- (LIPHT; 0/1 treatments) or high-intensity prehospital therapy (HIPHT; > 1 treatment) for AHF...
December 28, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29279134/mortality-after-an-episode-of-acute-heart-failure-in-a-cohort-of-patients-with-intermediate-ventricular-function-global-analysis-and-relationship-with-admission-department
#10
Òscar Miró, Patricia Javaloyes, Víctor Gil, Javier Jacob, Pablo Herrero-Puente, Francisco Javier Martín-Sánchez, Eva Salvo, Héctor Alonso, María Ángeles Juan Gómez, John Parissis, Pere Llorens
BACKGROUND AND OBJECTIVE: To compare the outcome of patients with acute heart failure (AHF) with a mid-range left ventricular ejection fraction (HFmrEF) with patients with a reduced (HFrEF) or preserved (HFpEF) left ventricular ejection fraction. PATIENTS AND METHOD: A prospective observational study included patients diagnosed with AHF in 41 emergency departments. Patients were divided into 3 groups: HFrEF<40%, HFmrEF 40-49% and HFpEF≥50%. We collected 38 independent variables and the adjusted and crude all-cause mortality at one-year in the HFmrEF group was compared with that of the HFrEF and HFpEF groups...
December 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29279127/self-assembly-of-oleylamine-modified-nano-fibrillated-cellulose-from-areca-husk-fibers-into-giant-vesicles
#11
Sumesh Soman, Asha Susan Chacko, V S Prasad, P Anju, B S Surya, K Vandana
Nanotechnology involving cellulosic substrates has generated a great attention owing to their exceptional physical and chemical properties. Self-assembled nanostructures obtained from carbohydrate polymers are of interest in the biomedical field for the biocompatibility and non-toxic nature. In the present study modification of nano-fibrillated cellulose (NFC) synthesised from the husk fibers of Areca catechu nuts (AHF) was studied by controlled regio-selective amidation with oleylamine (OA) and characterized...
February 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29261675/the-limited-prognostic-role-of-echocardiograms-in-short-term-follow-up-after-acute-decompensated-heart-failure-an-analysis-of-the-korean-heart-failure-korhf-registry
#12
Sung Hea Kim, Hyun-Joong Kim, Seongwoo Han, Byung-Su Yoo, Dong-Ju Choi, Jae-Joong Kim, Eun-Seok Jeon, Myeong-Chan Cho, Shung Chull Chae, Kyu-Hyung Ryu
BACKGROUND: The prognostic values of the left ventricular ejection fraction (LVEF) and end-diastolic dimension (LVEDD) have primarily been shown among patients with chronic heart failure (HF), with little representation of patients with acute HF (AHF). Therefore, we investigated the value of these echocardiographic parameters in predicting clinical outcomes among patients in the Korean Heart Failure (KorHF) Registry. METHODS: The KorHF Registry consists of 3,200 patients who were hospitalized with AHF from 2005 to 2009...
2017: PloS One
https://www.readbyqxmd.com/read/29259373/mesenchymal-stem-cells-rescue-acute-hepatic-failure-by-polarizing-m2-macrophages
#13
Yan-Wei Li, Chong Zhang, Qiu-Ju Sheng, Han Bai, Yang Ding, Xiao-Guang Dou
AIM: To investigate whether M1 or M2 polarization contributes to the therapeutic effects of mesenchymal stem cells (MSCs) in acute hepatic failure (AHF). METHODS: MSCs were transfused into rats with AHF induced by D-galactosamine (DGalN). The therapeutic effects of MSCs were evaluated based on survival rate and hepatocyte proliferation and apoptosis. Hepatocyte regeneration capacity was evaluated by the expression of the hepatic progenitor surface marker epithelial cell adhesion molecule (EpCAM)...
December 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29259209/hemographic-indices-are-associated-with-mortality-in-acute-heart-failure
#14
Wei-Ming Huang, Hao-Min Cheng, Chi-Jung Huang, Chao-Yu Guo, Dai-Yin Lu, Ching-Wei Lee, Pai-Feng Hsu, Wen-Chung Yu, Chen-Huan Chen, Shih-Hsien Sung
Hemographic indices have been associated with clinical outcomes in patients with chronic heart failure. We therefore investigated the prognostic values of hemographic indices in patients hospitalized for acute heart failure (AHF). Patients hospitalized primarily for AHF were drawn from an intramural registry. Hemographic indices, including white blood cell counts, neutrophil counts, neutrophil-to-lymphocyte ratio, reciprocal of lymphocyte (RL) and platelet-to-lymphocyte ratio were recorded. Among a total of 1923 participants (mean age 76 ± 12 years, 68% men), 875 patients died during a mean follow-up of 28...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29247970/comprehensive-biomechanical-characterization-of-feet-in-usma-cadets-comparison-across-race-gender-arch-flexibility-and-foot-types
#15
Jinsup Song, Kersti Choe, Michael Neary, Rebecca A Zifchock, Kenneth L Cameron, Michael Trepa, Marian T Hannan, Howard Hillstrom
Lower extremity musculoskeletal injuries are common, complex, and costly problems. Literature supports associations between static foot structure and dynamic foot function, as well as between overuse injury and demographic characteristics. Previous studies failed to provide a comprehensive biomechanical foot characteristics of at-risk military personnel. In this study, foot structure, function, and arch height flexibility (AHF) were objectively measured in 1090 incoming cadets (16.3% female, mean age of 18...
December 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29247531/effects-of-acute-phase-intensive-electrical-muscle-stimulation-in-frail-elderly-patients-with-acute-heart-failure-active-ems-rationale-and-protocol-for-a-multicenter-randomized-controlled-trial
#16
Shinya Tanaka, Kentaro Kamiya, Yuya Matsue, Ryusuke Yonezawa, Hiroshi Saito, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Kazuki Wakaume, Yoshiko Endo, Emi Maekawa, Minako Yamaoka-Tojo, Takaaki Shiono, Takayuki Inomata, Takashi Masuda, Junya Ako
In elderly patients with acute heart failure (AHF), clinical outcome is adversely affected by frailty. Although a number of potentially effective interventions for frailty have been reported, little is known about the effects of rehabilitation programs in frail elderly AHF patients. We postulated that addition of electrical muscle stimulation (EMS), which induces muscle contraction without requiring patient volition, to early rehabilitation would be efficacious in frail elderly AHF patients. The ACTIVE-EMS (Effects of Acute Phase Intensive Electrical Muscle Stimulation in Frail Elderly Patients With AHF; UMIN000019551) trial is a multicenter, randomized controlled trial that will enroll 80 patients from 3 hospitals in Japan...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29241303/body-fluid-status-assessment-by-bio-impedance-analysis-in-patients-presenting-to-the-emergency-department-with-dyspnea
#17
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea. Methods: A total of 100 patients who presented with dyspnea and suspected with AHF were analyzed in this study. We enrolled 50 AHF and 50 non-AHF patients discriminated through echocardiographic analysis and Framingham criteria and were matched by age and sex...
December 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29232324/vaccination-recommendations-for-adults-with-autoimmune-inflammatory-rheumatic-diseases-in-latin-america
#18
Claiton Viegas Brenol, Valderilio Feijo Azevedo, Pablo Eduardo Bonvehi, Paola Ximena Coral-Alvarado, Julio Granados, Roberto Muñoz-Louis, Carlos Pineda, Carla Vizzotti
BACKGROUND/OBJECTIVE: Patients with autoimmune inflammatory rheumatic diseases (AIRDs) are at increased risk of contracting severe infections and suffering complications, particularly when they are receiving immunomodulating therapy. Vaccination is an important means to prevent many potential infections and thereby reduce the morbidity and mortality associated with AIRD. The purpose of this consensus document is to provide health care professionals with recommendations for the vaccination of AIRD patients who reside in Latin America...
December 12, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29226819/adherence-to-mediterranean-diet-and-all-cause-mortality-after-an-episode-of%C3%A2-acute-heart-failure-results-of-the%C3%A2-medit-ahf%C3%A2-study
#19
Òscar Miró, Ramon Estruch, Francisco J Martín-Sánchez, Víctor Gil, Javier Jacob, Pablo Herrero-Puente, Sergio Herrera Mateo, Alfons Aguirre, Juan A Andueza, Pere Llorens
OBJECTIVES: The authors sought to evaluate clinical outcomes of patients after an episode of acute heart failure (AHF) according to their adherence to the Mediterranean diet (MedDiet). BACKGROUND: It has been proved that MedDiet is a useful tool in primary prevention of cardiovascular diseases. However, it is unknown whether adherence to MedDiet is associated with better outcomes in patients who have already experienced an episode of AHF. METHODS: We designed a prospective study that included consecutive patients diagnosed with AHF in 7 Spanish emergency departments (EDs)...
January 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29217383/detection-of-latino-virus-arenaviridae-mammarenavirus-naturally-infecting-calomys-callidus
#20
Jorlan Fernandes, Renata Carvalho de Oliveira, Alexandro Guterres, Débora Ferreira Barreto-Vieira, Ana Claudia Pereira Terças, Bernardo Rodrigues Teixeira, Marcos Alexandre Nunes da Silva, Gabriela Cardoso Caldas, Janice Mery Chicarino de Oliveira Coelho, Ortrud Monika Barth, Sergio Paulo D'Andrea, Cibele Rodrigues Bonvicino, Elba Regina Sampaio de Lemos
Mammarenavirus species are associated with a specific rodent host species, although an increasing number of virus has been associated to more than one host, suggesting that co-evolution is less robust than initially thought. There are few eco-epidemiological studies of South America mammarenaviruses in non-endemic areas of Arenavirus Hemorrhagic Fever, affecting specially our current knowledge about animal reservoirs and virus range and host-virus relations. In Brazil, seven arenavirus species were described in seven different rodent species...
December 4, 2017: Acta Tropica
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