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https://www.readbyqxmd.com/read/28742068/a-peptide-based-viral-inactivator-inhibits-zika-virus-infection-in-pregnant-mice-and-fetuses
#1
Yufeng Yu, Yong-Qiang Deng, Peng Zou, Qian Wang, Yanyan Dai, Fei Yu, Lanying Du, Na-Na Zhang, Min Tian, Jia-Nan Hao, Yu Meng, Yuan Li, Xiaohui Zhou, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Cheng-Feng Qin, Shibo Jiang, Lu Lu
Zika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has spread rapidly to more than 70 countries and territories. However, no specific vaccines or antiviral drugs are currently available to prevent or treat ZIKV infection. Here we report that a synthetic peptide derived from the stem region of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and other flaviviruses in vitro. We show that Z2 interacts with ZIKV surface protein and disrupts the integrity of the viral membrane...
July 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28741346/occurrence-state-and-molecular-structure-analysis-of-extracellular-proteins-with-implications-to-the-dewaterability-of-waste-activated-sludge
#2
Boran Wu, Bing-Jie Ni, Kristine Horvat, Liyan Song, Xiaoli Chai, Xiaohu Dai, Devinder Mahajan
The occurrence state and molecular structure of extracellular proteins were analyzed to reveal the influencing factors on the water-holding capacities of protein-like substances in waste activated sludge (WAS). The gelation process of extracellular proteins verified that advanced oxidation processes (AOPs) for WAS dewaterability improvement eliminated the water affinity of extracellular proteins and prevented these macromolecules to form stable colloidal aggregation. Isobaric tags for relative and absolute quantitation proteomics identified that most of extracellular proteins were originally derived from intracellular part and the proteins originally located at extracellular part were mainly membrane-associated...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28741317/significantly-enhanced-hydrogen-evolution-activity-of-freestanding-pd-ru-distorted-icosahedral-clusters-with-less-than-600-atoms
#3
Zhihui Dai, Suli Liu, Qinghua Zhang, Jianchun Bao, Yafei Li, Lin Gu
Freestanding metal nanoclusters can tune, precisely and effectively, the Gibbs free energy (ΔGH) of atomic hydrogen on the surface of materials. This enables the enhancement of hydrogen evolution activity. In this paper, we report a study of freestanding Pd-Ru distorted icosahedral clusters (ico-clusters) with less than 600 atoms using a simple one-pot synthesis method. This Pd-Ru ico-cluster can be used as an efficient electrocatalyst for the hydrogen evolution reaction (HER) in acidic water, which is a promising alternative to Pt...
July 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28740976/a-kinetic-study-of-the-ch2oo-criegee-intermediate-reaction-with-so2-h2o-2-ch2i2-and-i-atoms-using-oh-laser-induced-fluorescence
#4
Yiqiang Liu, Fenghua Liu, Siyue Liu, Dongxu Dai, Wenrui Dong, Xueming Yang
The OH laser induced fluorescence method was used to study the kinetics of CH2OO reacting with SO2, (H2O)2, CH2I2 and I atoms. Decay of CH2OO is not strictly first-order since its self-reaction is rapid. With this consideration, we derived the rate coefficient of CH2OO + SO2/(H2O)2/CH2I2/I taking into account the contribution of the CH2OO self-reaction. For the CH2OO + SO2 reaction, the rate coefficient is measured to be (3.88 ± 0.13) × 10(-11) cm(3) molecule(-1) s(-1) at 10 Torr, which agrees very well with a previously reported value obtained by directly monitoring CH2OO using the UV absorption method with the CH2OO self-reaction considered...
July 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28740660/brain-response-to-sleep-related-attentional-bias-in-patients-with-chronic-insomnia
#5
EDITORIAL
Xi-Jian Dai
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740543/self-assembly-of-semiconducting-plasmonic-gold-nanoparticles-with-enhanced-optical-property-for-photoacoustic-imaging-and-photothermal-therapy
#6
Zhen Yang, Jibin Song, Yunlu Dai, Jingyi Chen, Feng Wang, Lisen Lin, Yijing Liu, Fuwu Zhang, Guocan Yu, Zijian Zhou, Wenpei Fan, Wei Huang, Quli Fan, Xiaoyuan Chen
Although various noble metal and semiconducting molecules have been developed as photoacoustic (PA) agents, the use of semiconducting polymer-metal nanoparticle hybrid materials to enhance PA signal has not been explored. A novel semiconducting-plasmonic nanovesicle was fabricated by self-assembly of semiconducting poly(perylene diimide) (PPDI) and poly(ethylene glycol (PEG) tethered gold nanoparticles (Au@PPDI/PEG). A highly localized and strongly enhanced electromagnetic (EM) field is distributed between adjacent gold nanoparticles in the vesicular shell, where the absorbing collapsed PPDI is present...
2017: Theranostics
https://www.readbyqxmd.com/read/28739686/chemoprevention-by-quercetin-of-oral-squamous-cell-carcinoma-by-suppression-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-dmba-treated-hamsters
#7
Wen Zhang, Gang Yin, Jianguo Dai, Y U Sun, Robert M Hoffman, Zhijian Yang, Yuan Fan
BACKGROUND/AIM: The aim of this study was to investigate the effects of the flavonoid quercetin on chemoprevention of oral squamous cell carcinoma (OSCC). The study involved molecular signaling pathways in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. MATERIALS AND METHODS: DMBA (0.5%) was painted at the right buccal pouches of hamsters for 14 weeks to induce carcinoma. DMBA-treated hamsters received simultaneous doses of quercetin...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739164/a-sparse-representation-based-method-for-parcellation-of-the-resting-brain-and-its-application-to-treatment-resistant-major-depressive-disorder
#8
Ruiyang Ge, Daniel M Blumberger, Jonathan Downar, Zafiris J Daskalakis, Joseph Tham, Raymond Lam, Fidel Vila-Rodriguez
BACKGROUND: Parcellating brain regions into functionally homogeneous subdivisions is critical for understanding normal and abnormal brain functions. NEW METHOD: In this study, we developed a new sparse representation-based parcellation method for functional magnetic resonance imaging (fMRI) data, and applied the new method to investigate functional insular subdivisions in treatment-resistant major depressive disorder (MDD). Realistic simulations were implemented to demonstrate the feasibility of the method...
July 21, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28738973/interactive-effects-between-lymphotoxin-%C3%AE-252-polymorphism-and-habits-of-substance-use-on-risk-of-hepatocellular-carcinoma
#9
Jung-Fa Tsai, Shinn-Chern Chen, Zu-Yau Lin, Chia-Yen Dai, Jee-Fu Huang, Min-Lung Yu, Wan-Long Chuang
This case-control study aimed to assess the interactive effect between polymorphisms of lymphotoxin (LT) α +252 and habitual substance use on risk of hepatocellular carcinoma (HCC). We enrolled 150 pairs of sex- and age-matched HCC patients and unrelated healthy controls. LTα genotypes were detected with polymerase-chain reaction and restrictive fragment length polymorphisms. Information about habits of substance use was obtained through personal interview. Multivariate analysis indicated that LTα +252 G/G genotypes [odds ratio (OR) = 3...
July 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28738836/metabolism-associated-danger-signal-induced-immune-response-and-reverse-immune-checkpoint-activated-cd40-monocyte-differentiation
#10
REVIEW
Jin Dai, Pu Fang, Jason Saredy, Hang Xi, Cueto Ramon, William Yang, Eric T Choi, Yong Ji, Wei Mao, Xiaofeng Yang, Hong Wang
Adaptive immunity is critical for disease progression and modulates T cell (TC) and antigen-presenting cell (APC) functions. Three signals were initially proposed for adaptive immune activation: signal 1 antigen recognition, signal 2 co-stimulation or co-inhibition, and signal 3 cytokine stimulation. In this article, we propose to term signal 2 as an immune checkpoint, which describes interactions of paired molecules leading to stimulation (stimulatory immune checkpoint) or inhibition (inhibitory immune checkpoint) of an immune response...
July 24, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28738657/a-new-strategy-for-fabrication-of-water-dispersible-and-biodegradable-fluorescent-organic-nanoparticles-with-aie-and-esipt-characteristics-and-their-utilization-for-bioimaging
#11
Dazhuang Xu, Meiying Liu, Hui Zou, Jianwen Tian, Hongye Huang, Qing Wan, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Fluorescence probes play a crucial role in optical imaging for visualization of complex biological processes. As compared with conventional organic fluorogens, the probes with aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics show significant advantages in high quantum yield at concentrated and aggregated state, large Stokes shift and low cytotoxicity. However, the synthesis of AIE-active fluorescent probes through the ESIPT mechanism has received only very limited attention...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738546/a-new-method-for-the-simultaneous-enhancement-of-methane-yield-and-reduction-of-hydrogen-sulfide-production-in-the-anaerobic-digestion-of-waste-activated-sludge
#12
Xiaohu Dai, Chongliang Hu, Dong Zhang, Yinguang Chen
The biogas generated from anaerobic digestion (AD) also includes undesirable by-product such as hydrogen sulfide (H2S), which must be removed before the biogas can be used as a clean energy source. Therefore, it is necessary to find an appropriate strategy to simultaneously enhance the methane yield and reduce H2S production. An efficient strategy-pretreating sludge at pH 10 for 8d and adjusting the system at neutral pH to produce methane for 20d-is reported for the synchronous enhancement of methane production and reduction of H2S production during AD...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28738498/microrna-299-3p-suppresses-proliferation-and-invasion-by-targeting-vegfa-in-human-colon-carcinoma
#13
Jia-Yong Wang, Jin-Bo Jiang, Yuan Li, Yan-Lei Wang, Yong Dai
Accumulating evidences have shown that microRNAs (miRNAs) are vital regulators and possess huge capabilities in post-transcriptional control. Although a large number of miRNAs have been identified to be dysregulated in human cancers especially in colon cancer, our understandings of the function of most miRNAs are still largely limited. In this study, we have demonstrated that miR-299-3p plays a critical role in suppressing colon carcinoma progression by targeting Vascular Endothelial Growth Factor A (VEGFA)...
July 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738154/modifying-surface-chemistry-of-metal-oxides-for-boosting-dissolution-kinetics-in-water-by-liquid-cell-electron-microscopy
#14
Yue Lu, Jiguo Geng, Kuan Wang, Wei Zhang, Wenqiang Ding, Zhenhua Zhang, Shaohua Xie, Hongxing Dai, Fu-Rong Chen, Manling Sui
Dissolution of metal oxides is fundamentally important for understanding mineral evolution and micromachining oxide functional materials. In general, dissolution of metal oxides is a slow and inefficient chemical reaction. Here, by introducing oxygen deficiencies to modify the surface chemistry of oxides, we can boost the dissolution kinetics of metal oxides in water, as in situ demonstrated in a liquid environmental transmission electron microscope (LETEM). The dissolution rate constant significantly increases by 16-19 orders of magnitude, equivalently a reduction of 0...
July 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28738092/the-efficacy-of-jianpi-yiqi-therapy-for-chronic-atrophic-gastritis-a-systematic-review-and-meta-analysis
#15
Yun-Kai Dai, Yun-Zhan Zhang, Dan-Yan Li, Jin-Tong Ye, Ling-Feng Zeng, Qi Wang, Ling Hu
Jianpi Yiqi therapy (JYT) is a classical therapy in treating chronic atrophic gastritis (CAG), but the clinical effects of it are still contentious. The purpose of this article is to evaluate the efficacy and safety of JYT for CAG. Seven electronic databases including PubMed, Embase, Springer Link, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database), Wan-fang database, and CBM (Chinese Biomedicine Database) were searched from their inception to November 1, 2016. 13 randomized controlled trials (RCTs) with a total of 1119 participants were identified for analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28737174/inverted-battery-design-as-ion-generator-for-interfacing-with-biosystems
#16
Chengwei Wang, Kun Kelvin Fu, Jiaqi Dai, Steven D Lacey, Yonggang Yao, Glenn Pastel, Lisha Xu, Jianhua Zhang, Liangbing Hu
In a lithium-ion battery, electrons are released from the anode and go through an external electronic circuit to power devices, while ions simultaneously transfer through internal ionic media to meet with electrons at the cathode. Inspired by the fundamental electrochemistry of the lithium-ion battery, we envision a cell that can generate a current of ions instead of electrons, so that ions can be used for potential applications in biosystems. Based on this concept, we report an 'electron battery' configuration in which ions travel through an external circuit to interact with the intended biosystem whereas electrons are transported internally...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28736958/intraoperative-indocyanine-green-fluorescent-angiography-assisted-modified-superior-gluteal-artery-perforator-flap-for-reconstruction-of-sacral-pressure-sores
#17
Chun-Kai Chang, Chien-Ju Wu, Chun-Yu Chen, Chi-Yu Wang, Tzi-Shiang Chu, Kuo-Feng Hsu, Han-Ting Chiu, Hung-Hui Liu, Chang-Yi Chou, Chih-Hsin Wang, Chin-Ta Lin, Niann-Tzyy Dai, Yuan-Sheng Tzeng
Pressure sores are often observed in patients who are bedridden. They can be a severe problem not only for patients and their caregivers but also for plastic surgeons. Here, we describe a new method of superior gluteal artery perforator flap harvesting and anchoring with the assistance of intraoperative indocyanine green fluorescent angiography. In this report, we describe the procedure and outcomes for 19 patients with grades III and IV sacral pressure sores who underwent the operation between September 2015 and November 2016...
July 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28736660/effect-of-higher-order-aberrations-and-intraocular-scatter-on-contrast-sensitivity-measured-with-a-single-instrument
#18
Junlei Zhao, Fei Xiao, Haoxin Zhao, Yun Dai, Yudong Zhang
Higher-order aberrations (HOAs) and intraocular scatter lead to the degradation of image quality on the retina, and consequently deteriorate subjective visual performance. In this article, we modified an adaptive optics double-pass system to combine objective and subjective visual testing capabilities. Employing the modified DP system, we investigated the effects of HOAs and intraocular scatter on contrast sensitivity. Contrast sensitivity measurements were performed with HOAs either retained or corrected by adaptive optics, and with scatter either remaining at the natural eye-induced level or further enhanced by a set of three different scatter filters...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28735866/microrna-193-5p-modulates-angiogenesis-through-igf2-in-type-2-diabetic-cardiomyopathy
#19
Fan Yi, Yuqiang Shang, Bing Li, Shilin Dai, Wei Wu, Long Cheng, Xiancan Wang
BACKGROUND: Patients with diabetic cardiomyopathy are often associated with increasing risk of heart failure. In this work, we used animal model to characterize the angiogenic effect of microRNA-193-5p, miR-193-5p in type 2 diabetic Goto-Kakizaki (GK) rats' myocardial microvascular endothelial cells, MMEC(GK). METHODS: MiR-193-5p in MMEC(GK) was compared to its expression in Wistar rat MMEC. In MMEC(GK), miR-193-5p was downregulated through viral infection. Its angiogenic effects on MMEC(GK) migration and proliferation were assessed by transwell and MTT assays, respectively...
July 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28735185/mil-101-cr-go-for-dispersive-micro-solid-phase-extraction-of-pharmaceutical-residue-in-chicken-breast-used-in-microwave-assisted-coupling-with-hplc-ms-ms-detection
#20
Yudan Wang, Xinpeng Dai, Xi He, Lin Chen, Xiaohong Hou
In this work, MIL-101(Cr)@GO (Graphite Oxide) was synthesized using a hydrothermal synthesis method and was applied as a dispersive micro-solid-phase extraction (D-μ-SPE) sorbent for the efficient concentration of four residual drugs (metronidazole, MNZ; tinidazole, TNZ; chloramphenicol, CAP; sulfamethoxazole, SMX). Meanwhile, the extraction process was optimized by combining it with microwave-assisted extraction. Factors affecting the D-μ-SPE efficiency, such as selection of sorbent materials, pH of the sample solution, salting-out effect, amount of used material, extraction time, desorption solvent and desorption time, were studied...
July 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
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