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https://www.readbyqxmd.com/read/28549262/passive-sampling-of-wastewater-as-a-tool-for-the-long-term-monitoring-of-community-exposure-illicit-and-prescription-drug-trends-as-a-proof-of-concept
#1
J A Baz-Lomba, Christopher Harman, Malcolm Reid, Kevin V Thomas
A passive sampling device, the Polar Organic Chemical Integrative Sampler (POCIS), was calibrated in-situ over a 4-week period in Oslo (Norway) for 10 illicit drugs and pharmaceuticals with the goal of developing an approach for monitoring long-term wastewater drug loads. The calibrations were performed in triplicate using three different overlapping calibration sets under changing environmental conditions that allowed the uncertainty of the sampling rates to be evaluated. All 10 compounds exhibited linear uptake kinetics and provided sampling rates of between 0...
May 20, 2017: Water Research
https://www.readbyqxmd.com/read/28549176/effect-of-temperature-on-the-survival-and-development-of-three-forensically-relevant-dermestes-species-coleoptera-dermestidae
#2
Daniel Martín-Vega, Luisa M Díaz-Aranda, Arturo Baz, Blanca Cifrián
La mayoría de las especies del género Dermestes (Coleoptera: Dermestidae) son carroñeras durante la fase larvaria y la fase adulta, con preferencia por la materia orgánica seca. Debido a esto, los derméstidos son indicadores potencialmente útiles en las investigaciones forenses que impliquen restos humanos momificados y/o esqueléticos. Lamentablemente, los datos de referencia sobre el desarrollo de la mayoría de las especies de Dermestes de relevancia forense son escasos. Este estudio analiza el efecto de cinco temperaturas constantes (15, 20, 25, 30 y 35 °C) sobre la supervivencia y la tasa de desarrollo de tres de los derméstidos de mayor relevancia forense: Dermestes frischii Kugelan, Dermestes maculatus De Geer y Dermestes undulatus Brahm...
May 26, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28526264/celecoxib-aggravates-cardiac-apoptosis-in-l-name-induced-pressure-overload-model-in-rats-immunohistochemical-determination-of-cardiac-caspase-3-mcl-1-bax-and-bcl-2
#3
Sarah M Mosaad, Sawsan A Zaitone, Abdelazim Ibrahim, Amani A El-Baz, Dina M Abo-Elmatty, Yasser M Moustafa
The mechanism of celecoxib cardiovascular adverse events was earlier investigated; yet in-depth investigations are needed to assess the involvement of its pro-apoptotic effect throughout this process. An in-vivo chronic rat model of pressure overload employing Nʷ-nitro-l-arginine methyl ester (L-NAME) was tested at different time intervals to ensure the occurrence of persistent myocardial apoptosis along with pressure overload. Seven groups of male Wistar rats were assigned as (i) distilled water; (ii-iv) L-NAME (60 mg/kg) for 6, 12 or 16 weeks; (v-vii) L-NAME [16 weeks] + celecoxib (25, 50 or 100 mg/kg), from week 13 to week 16...
May 16, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28503790/proton-gradients-at-the-origin-of-life
#4
REVIEW
Nick Lane
Chemiosmotic coupling - the harnessing of electrochemical ion gradients across membranes to drive metabolism - is as universally conserved as the genetic code. As argued previously in these pages, such deep conservation suggests that ion gradients arose early in evolution, and might have played a role in the origin of life. Alkaline hydrothermal vents harbour pH gradients of similar polarity and magnitude to those employed by modern cells, one of many properties that make them attractive models for life's origin...
June 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28501963/salinity-driven-decadal-changes-in-phytoplankton-community-in-the-nw-arabian-gulf-of-kuwait
#5
Turki Al-Said, Aws Al-Ghunaim, D V Subba Rao, Faiza Al-Yamani, Kholood Al-Rifaie, Ali Al-Baz
Evaluation of hydrological data obtained between 2000 and 2013 from a time series station in Kuwait Bay (station K6) and an offshore southern location (station 18) off Kuwait showed drastic increase in salinity by 6 units. We tested the hypothesis that increased salinity impacted phytoplankton community characteristics in these semiarid waters. The Arabian Gulf receives seasonal freshwater discharge in the north via Shatt Al-Arab estuary with a peak during March-July. A north to south gradient in the proportion of the freshwater exists between station A in the vicinity of Shatt Al-Arab estuary and station 18 in the southern offshore area...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28496226/oral-cancer-early-delayed-diagnosis
#6
P Varela-Centelles, P Castelo-Baz, J Seoane-Romero
No abstract text is available yet for this article.
May 12, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28490598/development-of-clade-specific-and-broadly-reactive-live-attenuated-influenza-virus-vaccines-against-rapidly-evolving-h5-subtype-viruses
#7
Kobporn Boonnak, Yumiko Matsuoka, Weijia Wang, Amorsolo L Suguitan, Zhongying Chen, Myeisha Paskel, Mariana Baz, Ian Moore, Hong Jin, Kanta Subbarao
We have developed pandemic live attenuated influenza vaccines (pLAIV) against clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memory. In 2015, many human infections caused by a new clade (2.2.1.1) of goose/Guangdong (gs/GD) lineage H5N1 viruses were reported in Egypt that prompted updating of the H5N1 pLAIV. We explored two strategies to generate suitable pLAIVs: first to modify the hemagglutinin gene of a highly pathogenic wild-type (wt) clade 2.2.1.1 virus A/Egypt/N03434/2009 (Egy/09) (H5N1) with its unmodified neuraminidase (NA) gene; this virus was designated Egy/09 ca The second approach was to select a low pathogenicity avian influenza H5 virus that elicited antibodies that cross-reacted with a broad range of H5 viruses, including the Egypt H5N1 viruses and contained a novel NA subtype for humans...
May 10, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28487745/machine-learning-applications-in-medical-image-analysis
#8
EDITORIAL
Ayman El-Baz, Georgy Gimel'farb, Kenji Suzuki
No abstract text is available yet for this article.
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28483761/a-phase-1b-study-of-isatuximab-plus-lenalidomide-and-dexamethasone-for-relapsed-refractory-multiple-myeloma
#9
Thomas Martin, Rachid Baz, Don M Benson, Nikoletta Lendvai, Jeffrey Wolf, Pamela Munster, Alexander M Lesokhin, Claudine Wack, Eric Charpentier, Frank Campana, Ravi Vij
This phase 1b, open-label, dose-escalation study (NCT01749969) assessed the safety, efficacy, and pharmacokinetics of anti-CD38 monoclonal antibody isatuximab given in two schedules (3, 5, 10 mg/kg every other week [Q2W] or 10, 20 mg/kg weekly for 4 weeks then Q2W thereafter [QW/Q2W]), in combination with lenalidomide 25 mg (Days 1-21) and dexamethasone 40 mg (weekly), in patients with relapsed/refractory multiple myeloma (RRMM). Patients received 28-day treatment cycles; the primary objective was to determine the maximum tolerated dose (MTD) of isatuximab with lenalidomide and dexamethasone...
May 8, 2017: Blood
https://www.readbyqxmd.com/read/28481997/patterns-of-growth-body-composition-and-lipid-profiles-in-a-south-african-cohort-of-human-immunodeficiency-virus-infected-and-uninfected-children-a-cross-sectional-study
#10
Sarah M Ramteke, Stephanie Shiau, Marc Foca, Renate Strehlau, Francoise Pinillos, Faeezah Patel, Avy Violari, Afaaf Liberty, Ashraf Coovadia, Louise Kuhn, Stephen M Arpadi
Background.: Prior research in sub-Saharan Africa reports dyslipidemia in perinatally human immunodeficiency virus (HIV)-infected children receiving ritonavir-boosted lopinavir (LPV/r) compared with efavirenz; however, interpretation of findings is limited by lack of comparison data from HIV-uninfected children. Methods.: We conducted a cross-sectional analysis of lipid profiles and growth within a larger longitudinal cohort study of perinatally HIV-infected and HIV-uninfected children aged 4-9 years in Johannesburg, South Africa...
May 6, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28468797/selective-inhibition-of-nuclear-export-with-selinexor-in-patients-with-non-hodgkin-s-lymphoma
#11
John Kuruvilla, Michael Savona, Rachid Baz, Morten Mau-Sorensen, Nashat Gabrail, Ramiro Garzon, Richard Stone, Michael Wang, Lynn Savoie, Peter Martin, Ian Flinn, Meagan Jacoby, T J Unger, Jean R Saint-Martin, Tami Rashal, Sharon Friedlander, Robert Carlson, Michael Kauffman, Sharon Shacham, Martin Gutierrez
Patients with relapsed or refractory (R/R) non-Hodgkin's lymphoma (NHL) have a poor prognosis and limited treatment options. We evaluated selinexor, an orally bioavailable, first-in-class inhibitor of the nuclear export protein XPO1, in this phase 1 trial to assess safety and determine a recommended phase 2 dose (RP2D). Seventy-nine patients with various NHL histologies, including diffuse large B cell lymphoma (DLBCL), Richter's transformation, mantle cell lymphoma (MCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) were enrolled...
May 3, 2017: Blood
https://www.readbyqxmd.com/read/28464868/nutritional-status-and-correlated-socio-economic-factors-among-preschool-and-school-children-in-plantation-communities-sri-lanka
#12
Lahiru Sandaruwan Galgamuwa, Devika Iddawela, Samath D Dharmaratne, G L S Galgamuwa
BACKGROUND: Child malnutrition is a major public health concern worldwide, leading to higher morbidity and mortality. It is mostly preventable through public health and economic development. The aim of the present study was to determine socio-economic factors associated with nutritional status among children in plantation communities, Sri Lanka. METHODS: A cross-sectional study was performed among preschool and school going children in three rural communities of Sri Lanka from January to August 2014...
May 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28457217/the-role-of-fetuin-a-and-electrolytes-in-the-etiology-of-sialolithiasis
#13
Hasan Demirhan, Muhammet Yıldız, Özlem Önerci Çelebi, Şehide Baz, Berrin Berçik İnal, Özgür Yiğit
Objective The aim of this study was to investigate serum and saliva fetuin-A, protein, and electrolyte levels in patients with sialolithiasis. Study Design Prospective randomized controlled study. Setting Tertiary center. Subjects and Methods Twenty patients with recurrent sialadenitis secondary to submandibular salivary gland stones and 20 asymptomatic healthy volunteers without salivary gland stones were included in the study. Bimanual palpation and ultrasonography were performed in the patient and control groups...
May 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28453845/effect-of-repeated-vaccination-with-the-same-vaccine-component-against-2009-pandemic-influenza-a-h1n1-virus
#14
Iván Martínez-Baz, Itziar Casado, Ana Navascués, Jorge Díaz-González, Aitziber Aguinaga, Laura Barrado, Josu Delfrade, Carmen Ezpeleta, Jesús Castilla
Background.: The 2009 pandemic influenza A(H1N1) (A[H1N1]pdm09) vaccine component has remained unchanged from 2009. We estimate the effectiveness of current and prior inactivated influenza A(H1N1)pdm09 vaccination from influenza seasons 2010-2011 to 2015-2016. Methods.: Patients attended with influenza-like illness were tested for influenza. Four periods with continued A(H1N1)pdm09 circulation were included in a test-negative design. Results.: We enrolled 1278 cases and 2343 controls...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28452232/genetic-polymorphisms-of-il-23r-rs7517847-and-lep-rs7799039-among-egyptian-patients-with-hepatocellular-carcinoma
#15
Tahani Amer, Rizk El-Baz, Abdel-Rahman Mokhtar, Saad El-Shaer, Rami Elshazli, Ahmad Settin
BACKGROUND: Genetic polymorphisms of IL-23 R (rs7517847) and LEP (rs7799039) have been stated to be associated with various types of human cancers. The purpose of this work is to test the association of these genetic polymorphisms with hepatocellular carcinoma (HCC) among Egyptian patients. SUBJECTS AND METHODS: This study involved 150 unrelated Egyptian HCC patients in addition to 100 healthy controls from the same locality. DNA was genotyped for these genetic polymorphisms using the PCR-RFLP technique...
April 28, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28449877/two-stage-algorithm-vs-commonly-used-approaches-for-the-suspect-screening-of-complex-environmental-samples-analyzed-via-liquid-chromatography-high-resolution-time-of-flight-mass-spectroscopy-a-test-study
#16
Saer Samanipour, Jose A Baz-Lomba, Nikiforos A Alygizakis, Malcolm J Reid, Nikolaos S Thomaidis, Kevin V Thomas
LC-HR-QTOF-MS recently has become a commonly used approach for the analysis of complex samples. However, identification of small organic molecules in complex samples with the highest level of confidence is a challenging task. Here we report on the implementation of a two stage algorithm for LC-HR-QTOF-MS datasets. We compared the performances of the two stage algorithm, implemented via NIVA_MZ_Analyzer™, with two commonly used approaches (i.e. feature detection and XIC peak picking, implemented via UNIFI by Waters and TASQ by Bruker, respectively) for the suspect analysis of four influent wastewater samples...
April 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28407601/changes-in-household-food-insecurity-are-related-to-changes-in-bmi-and-diet-quality-among-michigan-head-start-preschoolers-in-a-sex-specific-manner
#17
Erica C Jansen, Nicole Kasper, Julie C Lumeng, Holly E Brophy Herb, Mildred A Horodynski, Alison L Miller, Dawn Contreras, Karen E Peterson
Children living in households that have recently become food insecure may be particularly vulnerable to adverse weight and dietary changes, but longitudinal studies examining these associations are lacking. Using data from 501 Head Start preschoolers from Michigan (48% male) who were followed during one school year as a part of a randomized obesity prevention trial, we examined changes in children's adiposity indices and dietary quality according to changes in household food insecurity. Household food insecurity change status was categorized as persistently food secure, became food secure, persistently food insecure, or became food insecure...
May 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28403106/baseline-serum-albumin-and-other-common-clinical-markers-are-prognostic-factors-in-colorectal-carcinoma-a-retrospective-cohort-study
#18
Sagrario González-Trejo, José F Carrillo, D Darlene Carmona-Herrera, Patricia Baz-Gutiérrez, Roberto Herrera-Goepfert, Gloria Núñez, Francisco J Ochoa-Carrillo, Dolores Gallardo-Rincón, Vincenzo Aiello-Crocifoglio, Luis F Oñate-Ocaña
The aim of the present study was to define the prognostic role of baseline serum albumin (BSA) in colorectal cancer (CRC) across tumor-node-metastasis (TNM) stages and other well defined prognostic factors. Many prognostic models in medicine employ BSA to define or refine treatments in very specific settings; in CRC, BSA has been found to be a prognostic factor as well. A retrospective cohort study of consecutive patients with CRC demonstrated by biopsy, who attended a cancer center during a 7-year period. Multivariate analysis was utilized to define prognostic factors associated with overall survival (OS) employing the Cox model...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28400475/an-ex-vivo-platform-for-the-prediction-of-clinical-response-in-multiple-myeloma
#19
Ariosto S Silva, Maria D Silva, Praneeth Sudalagunta, Allison I Distler, Timothy Jacobson, Aunshka Collins, Tuan Nguyen, Jinming Song, Dung-Tsa Chen, Lu Chen, Christopher L Cubitt, Rachid Baz, Lia Perez, Dmitri Rebatchouk, William Dalton, James Greene, Robert A Gatenby, Robert J Gillies, Eduardo Sontag, Mark B Meads, Kenneth Shain
Multiple myeloma (MM) remains treatable but incurable. Despite a growing armamentarium of effective agents, choice of therapy, especially in relapse, still relies almost exclusively on clinical acumen. We have developed a system, EMMA (Ex vivo Mathematical Myeloma Advisor), consisting of patient-specific mathematical models parameterized by an ex vivo assay that reverse engineers the intensity and heterogeneity of chemosensitivity of primary cells from MM patients, allowing us to predict clinical response to up to 31 drugs within 5 days post-bone marrow biopsy...
April 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/28389768/genetic-polymorphisms-of-nf%C3%AE%C2%BAb1-94ins-delattg-and-nf%C3%AE%C2%BAbia-881a-g-genes-in-egyptian-patients-with-colorectal-cancer
#20
Mohamed Ragab Youssef, Zeinab Ibraheim Attia, Rizk Ahmed El-Baz, Sameh Roshdy, Ahmad Settin
To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the same locality. For all participants, genetic polymorphisms of NFκB1-94ins/delATTG (rs28362491) and NFκBIA-881A/G (rs3138053) were detected by using restriction fragment length polymorphism polymerase chain reaction (RFLP-PCR). CRC patients showed a significantly higher frequency of the NFκB1-94ins/ins genotype than controls (30 vs...
April 7, 2017: Familial Cancer
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