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https://www.readbyqxmd.com/read/29136034/a-fast-stochastic-framework-for-automatic-mr-brain-images-segmentation
#1
Marwa Ismail, Ahmed Soliman, Mohammed Ghazal, Andrew E Switala, Georgy Gimel'farb, Gregory N Barnes, Ashraf Khalil, Ayman El-Baz
This paper introduces a new framework for the segmentation of different brain structures (white matter, gray matter, and cerebrospinal fluid) from 3D MR brain images at different life stages. The proposed segmentation framework is based on a shape prior built using a subset of co-aligned training images that is adapted during the segmentation process based on first- and second-order visual appearance characteristics of MR images. These characteristics are described using voxel-wise image intensities and their spatial interaction features...
2017: PloS One
https://www.readbyqxmd.com/read/29131804/assessing-the-performance-of-the-precise-dapt-and-paris-risk-scores-for-predicting-1-year-out-of-hospital-bleeding-in-acute-coronary-syndrome-patients
#2
Emad Abu-Assi, Sergio Raposeiras-Roubin, Rafael Cobas-Paz, Berenice Caneiro-Queija, Cristina Martínez-Reglero, José Manuel Rodríguez-Rodríguez, Antonio Baz, Andrés Íñiguez-Romo
AIMS: PRECISE-DAPT and PARIS risk scores (RSs) were recently developed to bleeding risk assessment in percutaneous coronary intervention (PCI) patients treated with dual antiplatelet therapy (DAPT). We aimed to assess the performance of these RSs at predicting out-of-hospital bleeding in patients with acute coronary syndrome (ACS). METHODS AND RESULTS:  Retrospectively, we studied 1926 consecutive ACS patients treated with PCI and DAPT. The performance of RSs for predicting one-year BARC type 2, 3 or 5 bleeding and BARC type 3 or 5 bleeding was assessed and compared...
November 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29120586/association-of-interleukin-8-gene-polymorphisms-and-expression-with-hepatocellular-carcinoma-in-egyptian-patients-with-liver-cirrhosis
#3
Omayma M Hassanin, Tarek M El-Masry, Ahmed El-Baz, Heba M Adel-Abou-Zaghla
Hepatocellular Carcinoma?(HCC) is one of the most common cancer in Egypt. Interleukin-8 Single Nucleotide Polymorphisms (-251 and +781 SNPs) are proposed genes for cancer susceptibility. Our aim was to evaluate the association of these two IL-8 SNPs polymorphisms and IL-8 gene expression with HCC in Egyptian patients with liver cirrhosis. IL-8 -251 and + 781 SNPs were assayed by TaqMan technique and IL-8 gene Expression study was done by Syber green method in 50 patients with liver cirrhosis (without HCC n=25and with HCC n=25)and 50 healthy controls...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29112131/juvenile-onset-diabetes-and-congenital-cataract-double-gene-mutations-mimicking-a-syndromic-diabetes-presentation
#4
Caroline Lenfant, Patrick Baz, Anne Degavre, Anne Philippi, Valérie Senée, Claire Vandiedonck, Céline Derbois, Marc Nicolino, Pierre Zalloua, Cécile Julier
Monogenic forms of diabetes may account for 1-5% of all cases of diabetes, and may occur in the context of syndromic presentations. We investigated the case of a girl affected by insulin-dependent diabetes, diagnosed at 6 years old, associated with congenital cataract. Her consanguineous parents and her four other siblings did not have diabetes or cataract, suggesting a recessive syndrome. Using whole exome sequencing of the affected proband, we identified a heterozygous p.R825Q ABCC8 mutation, located at the exact same amino-acid position as the p...
November 7, 2017: Genes
https://www.readbyqxmd.com/read/29091452/validation-of-trimethylamine-n-oxide-tmao-force-fields-based-on-thermophysical-properties-of-aqueous-tmao-solutions
#5
Daniel Markthaler, Johannes Zeman, Jörg Baz, Jens Smiatek, Niels Hansen
Five molecular models for trimethylamine N-oxide (TMAO) to be used in conjunction with compatible models for liquid water are evaluated by comparison of molecular dynamics (MD) simulation results to experimental data as functions of TMAO molality. The experimental data comprise thermodynamic properties (density, apparent molar volume, and partial molar volume at infinite dilution), transport properties (self-diffusion and shear viscosity), structural properties (radial distribution functions and degree of hydrogen bonding), and dielectric properties (dielectric spectra and static permittivity)...
November 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29070839/phosphorylable-tyrosine-residue-162-in-the-double-stranded-rna-dependent-kinase-pkr-modulates-its-interaction-with-sumo
#6
Carlos F de la Cruz-Herrera, Maite Baz-Martínez, Ahmed El Motiam, Santiago Vidal, Manuel Collado, Anxo Vidal, Manuel S Rodríguez, Mariano Esteban, Carmen Rivas
Activated dsRNA-dependent serine/threonine kinase PKR phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF2α), resulting in a shut-off of general translation, induction of apoptosis, and inhibition of virus replication. PKR can be activated by binding to dsRNA or cellular proteins such as PACT/RAX, or by its conjugation to ISG15 or SUMO. Here, we demonstrate that PKR also interacts with SUMO in a non-covalent manner. We identify the phosphorylable tyrosine residue 162 in PKR (Y162) as a modulator of the PKR-SUMO non-covalent interaction as well as of the PKR SUMOylation...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29062691/new-onset-refractory-status-epilepticus-due-to-primary-angiitis-of-the-central-nervous-system
#7
Rawan K Matar, Bader Alshamsan, Saleh Alsaleh, Hindi Alhindi, Khalid O Alahmedi, Sami Khairy, Salah Baz
Primary Angiitis of the central nervous system is a rare and poorly understood variant of vasculitis. We narrate a case of a 46-year-old male who presented with new onset refractory status epilepticus mimicking autoimmune encephalitis. In this case we are reporting clues that could be useful for diagnosis and extensive literature review on the topic.
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29058101/dock8-deficiency-presenting-as-an-ipex-like-disorder
#8
Fayhan J Alroqi, Louis-Marie Charbonnier, Sevgi Keles, Fatima Ghandour, Pierre Mouawad, Rami Sabouneh, Reem Mohammed, Abduarahman Almutairi, Janet Chou, Michel J Massaad, Raif S Geha, Zeina Baz, Talal A Chatila
PURPOSE: The dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive-combined immunodeficiency whose clinical spectra include recurrent infections, autoimmunity, malignancies, elevated serum IgE, eczema, and food allergies. Here, we report on patients with loss of function DOCK8 mutations with profound immune dysregulation suggestive of an immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)-like disorder. METHODS: Immunophenotyping of lymphocyte subpopulations and analysis of DOCK8 protein expression were evaluated by flow cytometry...
November 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29054258/comparative-approaches-for-classification-of-diabetes-mellitus-data-machine-learning-paradigm
#9
Md Maniruzzaman, Nishith Kumar, Md Menhazul Abedin, Md Shaykhul Islam, Harman S Suri, Ayman S El-Baz, Jasjit S Suri
BACKGROUND AND OBJECTIVE: Diabetes is a silent killer. The main cause of this disease is the presence of excessive amounts of metabolites such as glucose. There were about 387 million diabetic people all over the world in 2014. The financial burden of this disease has been calculated to be about $13,700 per year. According to the World Health Organization (WHO), these figures will more than double by the year 2030. This cost will be reduced dramatically if someone can predict diabetes statistically on the basis of some covariates...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29038711/study-of-the-c677t-and-1298ac-polymorphic-genotypes-of-mthfr-gene-in-autism-spectrum-disorder
#10
Farida El-Baz, Mohammed Abd El-Aal, Tarek Moustafa Kamal, Abdelrahim Abdrabou Sadek, Amr Ahmed Othman
BACKGROUND: Autism is currently known as "a behaviorally defined syndrome" manifested as impairment in social communication, repetitive routines and restricted interests. There is an increased risk of ASDs associated with common mutations affecting the folate/methylation cycle. AIM: The aim of this study was to identify C677T and 1298AC polymorphic genotypes of MTHFR gene among a sample of Egyptian children with autism and to make a phenotype-genotype correlation for the autistic patients...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29035822/intraoperative-direct-cortical-stimulation-motor-evoked-potentials-stimulus-parameter-recommendations-based-on-rheobase-and-chronaxie
#11
Tariq M Abalkhail, David B MacDonald, Ibrahim AlThubaiti, Faisal A AlOtaibi, Bent Stigsby, Amal A Mokeem, Iftetah A AlHamoud, Maher I Hassounah, Salah M Baz, Abdulaziz AlSemari, Hesham M AlDhalaan, Sameena Khan
OBJECTIVE: To determine optimal interstimulus interval (ISI) and pulse duration (D) for direct cortical stimulation (DCS) motor evoked potentials (MEPs) based on rheobase and chronaxie derived with two techniques. METHODS: In 20 patients under propofol/remifentanil anesthesia, 5-pulse DCS thenar MEP rheobase and chronaxie with 2, 3, 4 and 5ms ISI were measured by linear regression of five charge thresholds at 0.05, 0.1, 0.2, 0.5 and 1msD, and estimated from two charge thresholds at 0...
September 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29020054/a-novel-approach-for-automatic-visualization-and-activation-detection-of-evoked-potentials-induced-by-epidural-spinal-cord-stimulation-in-individuals-with-spinal-cord-injury
#12
Samineh Mesbah, Claudia A Angeli, Robert S Keynton, Ayman El-Baz, Susan J Harkema
Voluntary movements and the standing of spinal cord injured patients have been facilitated using lumbosacral spinal cord epidural stimulation (scES). Identifying the appropriate stimulation parameters (intensity, frequency and anode/cathode assignment) is an arduous task and requires extensive mapping of the spinal cord using evoked potentials. Effective visualization and detection of muscle evoked potentials induced by scES from the recorded electromyography (EMG) signals is critical to identify the optimal configurations and the effects of specific scES parameters on muscle activation...
2017: PloS One
https://www.readbyqxmd.com/read/28987989/automated-framework-for-accurate-segmentation-of-pressure-ulcer-images
#13
Begonya Garcia-Zapirain, Ahmed Shalaby, Ayman El-Baz, Adel Elmaghraby
Ulcer tissue segmentation is of immense importance in helping medical personnel to assess wounds. This paper introduces a new computational framework employing state-of-the-art image processing techniques to segment pressure ulcer tissue structures from color images. The framework integrates a visual appearance model of an observed input image with prior color information from an available database of previously stored color RGB images. The following four processing steps are performed. First, to minimize the execution time and enhance the segmentation accuracy, a region-of-interest (ROI) of the whole ulcer area is automatically identified based on contrast changes...
September 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28946785/survival-and-clinical-events-related-to-end-stage-liver-disease-associated-with-hcv-prior-to-the-era-of-all-oral-direct-acting-antiviral-treatments
#14
Javier Mar, Iván Martínez-Baz, Oliver Ibarrondo, Regina Juanbeltz, Ramón San Miguel, Itziar Casado, Aisling O'Leary, Jesús Castilla
BACKGROUND: The aim of this study was to describe the natural long-term course of end-stage liver disease associated with chronic hepatitis C (HCV) infection by measuring survival and complication rates in the era prior to the arrival of new direct-acting antiviral (DAA) drugs. METHODS: A retrospective population-based cohort study was designed to establish the follow-up of patients hospitalized for a decompensated cirrhotic event or hepatocellular carcinoma using electronic records from hospital discharge databases from 2009 to 2015...
September 26, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28937266/statistical-analysis-of-adcs-and-clinical-biomarkers-in-detecting-acute-renal-transplant-rejection
#15
Hollis Elizabeth, Shehata Mohamed, Mohamed Abou El-Ghar, Ghazal Mohammed, Tarek El-Diasty, Merchant Michael, Andrew E Switala, Ayman El-Baz
OBJECTIVE: The main goal of this study is to determine which parameters [e.g. clinical biomarkers, demographics and image-markers using 4D (3D + b-value) diffusion-weighted MRI (DW-MRI)] are more correlated with transplanted kidney status in patients who have undergone kidney transplantation, and can be used for early assessment of acute renal rejection. METHODS: The study included 16 patients with stable graft function and 37 patients with acute rejection (AR), determined by renal biopsy post-transplantation...
December 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28930613/an-automated-approach-for-early-detection-of-diabetic-retinopathy-using-sd-oct-images
#16
Ahmed H ElTanboly, Agustina Palacio, Ahmed M Shalaby, Andrew E Switala, Omar Helmy, Shlomit Schaal, Ayman El-Baz
  This study was to demonstrate the feasibility of an automatic approach for early detection of diabetic retinopathy (DR) from SD-OCT images. These scans were prospectively collected from 200 subjects through the fovea then were automatically segmented, into 12 layers. Each layer was characterized by its thickness, tortuosity, and normalized reflectivity. 26 diabetic patients, without DR changes visible by funduscopic examination, were matched with 26 controls, according to age and sex, for purposes of statistical analysis using mixed effects ANOVA...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930568/medical-imaging-diagnosis-of-early-alzheimer-s-disease
#17
Fatma El-Zahraa A El-Gamal, Mohammed M Elmogy, Mohammed Ghazal, Ahmed Atwan, Manual F Casanova, Gregory N Barnes, Ayman El-Baz, Hassan Hajjdiab
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases that influences the central nervous system, often leading to dire consequences for quality of life. The disease goes through some stages mainly divided into early, moderate, and severe. Among them, the early stage is the most important as medical intervention has the potential to alter the natural progression of the condition. In practice, the early diagnosis is a challenge since the neurodegenerative changes can precede the onset of clinical symptoms by 10-15 years...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930562/alzheimer-s-disease-diagnostics-by-a-3d-deeply-supervised-adaptable-convolutional-network
#18
Ehsan Hosseini-Asl, Mohammed Ghazal, Ali Mahmoud, Ali Aslantas, Ahmed M Shalaby, Manual F Casanova, Gregory N Barnes, Georgy Gimel'farb, Robert Keynton, Ayman El-Baz
Early diagnosis is playing an important role in preventing progress of the Alzheimer's disease (AD). This paper proposes to improve the prediction of AD with a deep 3D Convolutional Neural Network (3D-CNN), which can show generic features capturing AD biomarkers extracted from brain images, adapt to different domain datasets, and accurately classify subjects with improved fine-tuning method. The 3D-CNN is built upon a convolutional autoencoder, which is pre-trained to capture anatomical shape variations in structural brain MRI scans for source domain...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930545/classification-of-retinal-diseases-based-on-oct-images
#19
Nabila Eladawi, Mohammed M Elmogy, Mohammed Ghazal, Omar Helmy, Ahmed Aboelfetouh, Alaa Riad, Shlomit Schaal, Ayman El-Baz
Optical Coherence Topography (OCT) is an emerging biomedical imaging technology that offers non-invasive real-time, high-resolution imaging of highly scattering tissues. It is widely used in ophthalmology to perform diagnostic imaging on the structure of the anterior eye and the retina. Clinical studies are carried out to assess the application of OCT for some retinal diseases. OCT can provide means for early detection for various types of diseases because morphological changes often occur before the physical symptoms of these diseases...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929740/use-of-mobile-device-data-to-better-estimate-dynamic-population-size-for-wastewater-based-epidemiology
#20
Kevin V Thomas, Arturo Amador, Jose Antonio Baz-Lomba, Malcolm Reid
Wastewater-based epidemiology is an established approach for quantifying community drug use and has recently been applied to estimate population exposure to contaminants such as pesticides and phthalate plasticizers. A major source of uncertainty in the population weighted biomarker loads generated is related to estimating the number of people present in a sewer catchment at the time of sample collection. Here, the population quantified from mobile device-based population activity patterns was used to provide dynamic population normalized loads of illicit drugs and pharmaceuticals during a known period of high net fluctuation in the catchment population...
September 20, 2017: Environmental Science & Technology
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