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https://www.readbyqxmd.com/read/28098103/relation-of-fibroblast-growth-factor-23-and-cardiovascular-calcification-in-end-stage-kidney-disease-patients-on-regular-hemodialysis
#1
Tarek Zakaria El Baz, Osama Ahmed Khamis, Osama Ashry Ahmed Gheith, Salama Saad Abd Ellateif, Abdallah Mahmoud Abdallah, Hussein Chahine Abd El Aal
More than half of deaths in end-stage kidney disease (ESKD) patients are due to cardiovascular disease. Elevated fibroblast growth factor 23 (FGF-23) was found to be associated with mortality in hemodialysis (HD) patients and correlates with peripheral calcification. Aortic calcification is associated with coronary artery calcification. Both aortic and peripheral vascular calcifications were associated with mortality in chronic kidney disease. We aimed to investigate the relation between intact FGF-23 and cardiovascular calcification in patients with ESKD who were maintained on regular HD...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28073829/dutpase-dut-is-mutated-in-a-novel-monogenic-syndrome-with-diabetes-and-bone-marrow-failure
#2
Reinaldo Sousa Dos Santos, Mathilde Daures, Anne Philippi, Sophie Romero, Lorella Marselli, Piero Marchetti, Valérie Senée, Delphine Bacq, Céline Besse, Baz Baz, Laura Marroquí, Sarah Ivanoff, Julien Masliah-Planchon, Marc Nicolino, Jean Soulier, Gérard Socié, Decio L Eizirik, Jean-François Gautier, Cécile Julier
We describe a new syndrome characterized by early onset diabetes mellitus, associated with bone marrow failure affecting mostly the erythrocytic lineage. Using whole exome sequencing in a remotely consanguineous patient from a family with two affected siblings, we identified a single homozygous missense mutation (chr15.hg19:g.48,626,619A>G) located in the dUTPase (DUT) gene (NCBI Gene ID: 1854), affecting both the mitochondrial (DUT-M p.Y142C) and the nuclear (DUT-N p.Y54C) isoforms. We found the same homozygous mutation in an unrelated consanguineous patient with diabetes and bone marrow aplasia from a family with two affected siblings, while none of the >60,000 subjects from the Exome Aggregation Consortium (ExAC) was homozygous for this mutation...
January 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28063874/polarity-protein-par3-bazooka-follows-myosin-dependent-junction-repositioning
#3
Mo Weng, Eric Wieschaus
The polarity protein Par3/Bazooka (Baz) has been established as a central component of the apical basal polarity system that determines the position of cell-cell junctions in epithelial cells. Consistent with that view, we show that shortly before gastrulation in Drosophila, Baz protein in the mesoderm is down-regulated from junctional sites in response to Snail (Sna) expression. This down-regulation leads to a specific decrease in adherens junctions without affecting other E-Cadherin pools. However, we further show that, interactions between Baz and junctions are not unidirectional...
January 5, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28063376/a-comprehensive-non-invasive-framework-for-diagnosing-prostate-cancer
#4
Islam Reda, Ahmed Shalaby, Mohammed Elmogy, Ahmed Abou Elfotouh, Fahmi Khalifa, Mohamed Abou El-Ghar, Ehsan Hosseini-Asl, Georgy Gimel'farb, Naoufel Werghi, Ayman El-Baz
Early detection of prostate cancer increases chances of patients' survival. Our automated non-invasive system for computer-aided diagnosis (CAD) of prostate cancer segments the prostate on diffusion-weighted magnetic resonance images (DW-MRI) acquired at different b-values, estimates its apparent diffusion coefficients (ADC), and classifies their descriptors - empirical cumulative distribution functions (CDF) - with a trained deep learning network. To segment the prostate, an evolving geometric (level-set-based) deformable model is guided by a speed function depending on intensity attributes extracted from the DW-MRI with nonnegative matrix factorization (NMF)...
December 23, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28058164/the-efficacy-of-intravitreal-bevacizumab-in-vitreous-hemorrhage-of-diabetic-subjects
#5
Cengiz Alagöz, Yusuf Yıldırım, Murat Kocamaz, Ökkeş Baz, Uğur Çiçek, Burcu Çelik, Halil İbrahim Demirkale, Ahmet Taylan Yazıcı, Muhittin Taşkapılı
OBJECTIVES: To evaluate the efficacy of intravitreal bevacizumab (IVB) in the resolution of vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR). MATERIALS AND METHODS: Seventy eyes of 70 patients (43 male, mean age 55.6±12.2 years) diagnosed with VH secondary to PDR were evaluated retrospectively. Demographic characteristics of the patients, baseline and final clinical results, and the interventions the patients were subject to were recorded...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28027671/nutrition-status-of-primary-school-students-in-two-rural-regions-of-guinea-bissau
#6
Edward Saltzman, Nina Schlossman, Carrie A Brown, Ionela Balan, Paul Fuss, Payal Batra, Augusto Braima de Sa, Mary Kyla Shea, William M Pruzensky, Carlito Bale, Susan B Roberts
BACKGROUND: The nutrition status of primary schoolchildren in Africa has received relatively little attention in comparison to that of younger children. We surveyed primary school students in Guinea-Bissau, a nation that is among the poorest in the world. OBJECTIVE: Anthropometry and prevalence of anemia and vitamin A deficiency were assessed in schoolchildren participating in International Partnership for Human Development's school feeding program in 2 regions of Guinea-Bissau...
January 1, 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28026713/a-family-centered-lifestyle-intervention-for-obese-six-to-eight-year-old-children-results-from-a-one-year-randomized-controlled-trial-conducted-in-montreal-canada
#7
Tamara R Cohen, Tom J Hazell, Catherine A Vanstone, Celia Rodd, Hope A Weiler
OBJECTIVES: Childhood obesity interventions should be family-centered and focused on lifestyle behaviours that achieve sustainable reductions in adiposity. The primary objective of this randomized controlled trial was to test a family-centered lifestyle intervention using Canada's Food and Physical Activity (PA) Guidelines to reduce body mass index-for-age z-scores (BAZ) in overweight and obese (OW/OB) children. METHODS: Children (n = 78; ages 6-8.5 years) were randomized to standard (StnTx) or modified (ModTx) interventions or control (Ctrl)...
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28018534/does-psychological-safety-impact-the-clinical-learning-environment-for-resident-physicians-results-from-the-va-s-learners-perceptions-survey
#8
Karina D Torralba, Lawrence K Loo, John M Byrne, Samuel Baz, Grant W Cannon, Sheri A Keitz, Annie B Wicker, Steven S Henley, T Michael Kashner
BACKGROUND : Psychological safety (PS) is the perception that it is safe to take interpersonal risks in the work environment. In teaching hospitals, PS may influence the clinical learning environment for trainees. OBJECTIVE : We assessed whether resident physicians believe they are psychologically safe, and if PS is associated with how they rate satisfaction with their clinical learning experience. METHODS : Data were extracted from the Learners' Perceptions Survey (LPS) of residents who rotated through a Department of Veterans Affairs health care facility for academic years 2011-2014...
December 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28017335/two-decades-of-lung-retransplantation-a-single-center-experience
#9
David J Hall, Erol V Belli, Jon A Gregg, Juan C Salgado, Maher A Baz, E Denmark Staples, Thomas M Beaver, Tiago N Machuca
BACKGROUND: Lung retransplantation (ReTx) comprises an increasing share of lung transplants and recently has shown improved outcomes. The aim of this study was to identify risk factors affecting overall survival after pulmonary ReTx. METHODS: The United Network for Organ Sharing database was used to identify patients undergoing lung transplantation at our institution from 1995 to 2014. Of the total 542 lung transplants performed, 87 (16.1%) were ReTxs. The primary outcome was overall survival...
December 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28012556/-crossed-renal-ectopia-in-a-patient-with-a-complicated-sigma-neoplasia
#10
Luis Eduardo Pérez-Sánchez, Mauricio Burneo-Esteves, Adriá Rosat-Rodrigo, Caleb Baz-Figueroa, Antonio Dámaso Pérez-Álvarez, Manuel Ángel Barrera-Gómez
BACKGROUND: Crossed renal ectopia is a rare pathology that is often asymptomatic. Intraoperative detection with a sigma complicated neoplasia is more infrequent and requires correct management to avoid a renal ureteral injury. AIM: To present a case report of a patient with a sigma complicated neoplasia and a crossed renal ectopia detected incidentally. CASE REPORT: We present the case of a 62-year-old man that was submitted for emergency surgery for a sigma perforated neoplasm, and who presented with a previously undiagnosed left-side CRE...
December 21, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27998085/structural-insight-into-ns5-of-zika-virus-leading-to-the-discovery-of-mtase-inhibitors
#11
Preyesh Stephen, Mariana Baz, Guy Boivin, Sheng-Xiang Lin
Zika virus (ZIKV) is an emerging mosquito-borne virus recently linked to intrauterine growth restriction including abnormal fetal brain development. The recent outbreak of ZIKV reached pandemic level resulting in an alarming public health emergency. At present, there is limited understanding of the infectious mechanism and no approved therapy. Nonstructural protein 5 is essential for capping and replication of viral RNA and comprises a methyltransferase (MTase) and RNA dependent RNA polymerase domain. Here we used molecular modeling to obtain the structure of ZIKV MTase and molecular docking to identify the additional hydrophobic region uniquely conserved in flavivirus MTase that can be used as a druggable site...
December 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27976726/increased-levels-of-the-oxidative-stress-biomarker-8-iso-prostaglandin-f2%C3%AE-in-wastewater-associated-with-tobacco-use
#12
Yeonsuk Ryu, Emma Gracia-Lor, Richard Bade, J A Baz-Lomba, Jørgen G Bramness, Sara Castiglioni, Erika Castrignanò, Ana Causanilles, Adrian Covaci, Pim de Voogt, Felix Hernandez, Barbara Kasprzyk-Hordern, Juliet Kinyua, Ann-Kathrin McCall, Christoph Ort, Benedek G Plósz, Pedram Ramin, Nikolaos I Rousis, Malcolm J Reid, Kevin V Thomas
Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27970304/tct-137-influence-of-non-culprit-lesions-management-on-outcomes-in-patients-over-75-years-old-with-st-elevated-myocardial-infarction-results-from-the-estrofa-mi-75-nation-wide-registry
#13
Jose M de la Torre Hernandez, Joan Antoni Gomez Hospital, Salvatore Brugaletta, Jose Antonio Baz, Armando Perez de Prado, Ramon Lopez Palop, Ana Belen Cid Alvarez, Tamara Garcia Camarero, Alejandro Diego Nieto, Federico Gimeno, Jose Antonio Fernandez Diaz, Juan Sanchis Fores, Fernando Alfonso, Roberto Blanco, Javier Botas, Javier Navarro Cuartero, Jose Moreu Burgos, Francisco Bosa, Jose Miguel Vegas, Jaime Elizaga, Antonio Luis Arrebola Moreno, Joseantonio Linares Vicente, Felipe Hernandez, Neus Salvatella Giralt, Marta Monteagudo, Alfredo Gomez Jaume, Xavier Carrillo, Roberto Martin-Reyes, Fernando Lozano, Jose Rumoroso, Leire Andraka, Antonio J Dominguez
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970282/tct-120-primary-angioplasty-for-patients-over-75-years-old-in-cardiogenic-shock-contemporary-results-and-prognostic-predictors-from-the-estrofa-mi-75-nationwide-registry
#14
Jose M de la Torre Hernandez, Salvatore Brugaletta, Joan Antoni Gomez Hospital, Jose Antonio Baz, Armando Perez de Prado, Ramon Lopez Palop, Ana Belen Cid Alvarez, Tamara Garcia Camarero, Alejandro Diego Nieto, Federico Gimeno, Jose Antonio Fernandez Diaz, Juan Sanchis Fores, Fernando Alfonso, Roberto Blanco, Javier Botas, Javier Navarro Cuartero, Jose Moreu Burgos, Francisco Bosa, Jose Miguel Vegas, Jaime Elizaga, Antonio Luis Arrebola Moreno, Jose R Ruiz Arroyo, Felipe Hernandez, Neus Salvatella Giralt, Marta Monteagudo, Alfredo Gomez Jaume, Xavier Carrillo, Roberto Martin-Reyes, Fernando Lozano, Jose Rumoroso, Leire Andraka, Antonio J Dominguez
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969849/tct-491-comparative-analysis-of-the-right-radial-vascular-access-vs-left-at-more-than-10-000-diagnostic-coronary-angiography
#15
Etelberto Hernandez, Victor Jimenez Diaz, Pablo Juan-Salvadores, Jorge Vitela, Jose Antonio Baz Alonso, Alberto Ortiz, Guillermo Bastos Fernández, Saleta Fernández Barbeira, Antonio De Miguel Castro, Jorge Andrade Pacheco, Carlos Enrique Saldaña Luna, Giovanny Ponte, Josue Ponce, Jorge SepúlvedaSepúlveda, Angel Salgado, Andres Iñiguez
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969720/tct-371-anatomical-complications-and-difficulties-of-the-radial-and-ulnar-access-for-percutaneous-coronary-interventions-analysis-in-more-than-10-000-patients
#16
Jorge Vitela, Victor Jimenez Diaz, Etelberto Hernandez, Pablo Juan-Salvadores, Saleta Fernández Barbeira, Antonio de Miguel, Guillermo Bastos Fernández, Alberto Ortiz Zaez, Jorge SepúlvedaSepúlveda, Carlos Enrique Saldaña Luna, Giovanny Ponte, Josue Ponce, Jose Antonio Baz Alonso, Andres Iñiguez
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27958249/physical-growth-and-nutritional-status-assessment-of-school-children-in-enugu-nigeria
#17
J N Eze, T Oguonu, N C Ojinnaka, B C Ibe
BACKGROUND: Physical growth of a child is a reflection of its state of nutrition. In some developing countries such as Nigeria with changing economy and rapidly growing population, the nutritional status of the children is a reflection of the general well-being of the society. MATERIALS AND METHODS: This was a descriptive cross-sectional study in which participants were selected using a multistage sampling method. Heights and weights of randomly selected school children aged 6-12 years were measured using standard protocols...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27931685/evaluation-of-different-laboratory-methods-for-rapid-diagnosis-of-tuberculous-pleurisy
#18
Safaa Amer, Azza El Hefnawy, Nashwa Abdel Wahab, Hadir Okasha, Amira Baz
BACKGROUND/OBJECTIVE: Tuberculous pleurisy is a diagnostic challenge due to its nonspecific clinical presentation, paucibacillary nature of the effusion together with the inefficiency of conventional laboratory methods motivating the evaluation of variable diagnostic strategies. METHODS: Using thoracoscopy, the pleural cavity of 50 patients with undiagnosed exudative pleural effusion were fully examined and biopsy specimens of affected parietal pleura were taken under direct vision...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27927582/clonal-haemopoiesis-and-therapy-related-myeloid-malignancies-in-elderly-patients-a-proof-of-concept-case-control-study
#19
Nancy K Gillis, Markus Ball, Qing Zhang, Zhenjun Ma, YuLong Zhao, Sean J Yoder, Maria E Balasis, Tania E Mesa, David A Sallman, Jeffrey E Lancet, Rami S Komrokji, Alan F List, Howard L McLeod, Melissa Alsina, Rachid Baz, Kenneth H Shain, Dana E Rollison, Eric Padron
BACKGROUND: Clonal haemopoiesis of indeterminate potential (CHIP) is an age-associated genetic event linked to increased risk of primary haematological malignancies and increased all-cause mortality, but the prevalence of CHIP in patients who develop therapy-related myeloid neoplasms is unknown. We did this study to investigate whether chemotherapy-treated patients with cancer who have CHIP are at increased risk of developing therapy-related myeloid neoplasms. METHODS: We did a nested, case-control, proof-of-concept study to compare the prevalence of CHIP between patients with cancer who later developed therapy-related myeloid neoplasms (cases) and patients who did not develop these neoplasms (controls)...
December 2, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27922238/parental-perception-and-child-s-nutritional-status
#20
S Songül Yalçın, Esra Serdaroğlu, O Tolga İnce
Childhood obesity is a health hazard increasing worldwide. Preschool period which is under supervision of parents is a critical period to detect overweight and take precautions. We studied the factors affecting parental estimation of their preschool child's weight. Three hundred sixty seven mothers completed questionnaires consisting of child's and parents' anthropometric measurements, parents' assessment of their child's and their own weight status, and general information about their lifestyle. Mothers also chose their wish for current and future body image of their child from child drawings representing percentiles...
2016: Turkish Journal of Pediatrics
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