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https://www.readbyqxmd.com/read/29766673/genomic-characterization-of-individuals-presenting-extreme-phenotypes-of-high-and-low-risk-to-develop-tobacco-induced-lung-cancer
#1
Juan Pablo Fusco, Guillermo Pita, María José Pajares, Maria Pilar Andueza, Ana Patiño-García, Juan P de-Torres, Alfonso Gurpide, Javier Zulueta, Rosario Alonso, Nuria Alvarez, Ruben Pio, Ignacio Melero, Miguel F Sanmamed, Maria Rodriguez Ruiz, Ignacio Gil-Bazo, Jose María Lopez-Picazo, Ciro Casanova, Rebeca Baz Davila, Antonio Agudo, Maria Dolores Lozano, Alvaro Gonzalez, Nuria Sala, Eva Ardanaz, Javier Benitez, Luis Montuenga, Anna Gonzalez-Neira, Jose Luis Perez-Gracia
Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome-wide association study to characterize individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced non-small cell lung cancer (NSCLC), and we validated our results. We hypothesized that this strategy would enrich the frequencies of the alleles that contribute to the observed traits. We genotyped 2.37 million SNPs in 95 extreme phenotype individuals, that is: heavy smokers that either developed NSCLC at an early age (extreme cases); or did not present NSCLC at an advanced age (extreme controls), selected from a discovery set (n = 3631)...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29753814/genetic-variation-in-the-mapk-erk-pathway-affects-contact-hypersensitivity-responses
#2
Julien M D Legrand, Edwige Roy, Batoul Baz, Pamela Mukhopadhyay, Ho Yi Wong, Ramesh Ram, Grant Morahan, Graeme Walker, Kiarash Khosrotehrani
Using a genetic resource that enables rapid mapping of genes for complex traits, we demonstrate dramatic diversity between murine strains in response to immune challenge. We identified several candidate genes that point to the MAPK/ERK pathway as a key modulator of this process.
May 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29740501/risk-factors-of-neonatal-mortality-and-child-mortality-in-bangladesh
#3
Md Maniruzzaman, Harman S Suri, Nishith Kumar, Md Menhazul Abedin, Md Jahanur Rahman, Ayman El-Baz, Makrand Bhoot, Jagjit S Teji, Jasjit S Suri
Background: Child and neonatal mortality is a serious problem in Bangladesh. The main objective of this study was to determine the most significant socio-economic factors (covariates) between the years 2011 and 2014 that influences on neonatal and child mortality and to further suggest the plausible policy proposals. Methods: We modeled the neonatal and child mortality as categorical dependent variable (alive vs death of the child) while 16 covariates are used as independent variables using χ2 statistic and multiple logistic regression (MLR) based on maximum likelihood estimate...
June 2018: Journal of Global Health
https://www.readbyqxmd.com/read/29691724/neuroimmunologic-and-neurotrophic-interactions-in-autism-spectrum-disorders-relationship-to-neuroinflammation
#4
REVIEW
Kshama Ohja, Evelyne Gozal, Margaret Fahnestock, Lu Cai, Jun Cai, Jonathan H Freedman, Andy Switala, Ayman El-Baz, Gregory Neal Barnes
Autism spectrum disorders (ASD) are the most prevalent set of pediatric neurobiological disorders. The etiology of ASD has both genetic and environmental components including possible dysfunction of the immune system. The relationship of the immune system to aberrant neural circuitry output in the form of altered behaviors and communication characterized by ASD is unknown. Dysregulation of neurotrophins such as BDNF and their signaling pathways have been implicated in ASD. While abnormal cortical formation and autistic behaviors in mouse models of immune activation have been described, no one theory has been described to link activation of the immune system to specific brain signaling pathways aberrant in ASD...
April 24, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29691225/suppression-of-epithelial-folding-at-actomyosin-enriched-compartment-boundaries-downstream-of-wingless-signalling-in-drosophila
#5
Jose M Urbano, Huw W Naylor, Elena Scarpa, Leila Muresan, Bénédicte Sanson
Epithelial folding shapes embryos and tissues during development. Here, we investigate the coupling between epithelial folding and actomyosin-enriched compartmental boundaries. The mechanistic relationship between the two is unclear, because actomyosin-enriched boundaries are not necessarily associated with folds. Also, some cases of epithelial folding occur independently of actomyosin contractility. We investigated the shallow folds called parasegment grooves that form at boundaries between anterior and posterior compartments in the early Drosophila embryo...
April 24, 2018: Development
https://www.readbyqxmd.com/read/29686433/population-abundance-and-ecosystem-service-provision-the-case-of-birds
#6
Kevin J Gaston, Daniel T C Cox, Sonia B Canavelli, Daniel García, Baz Hughes, Bea Maas, Daniel Martínez, Darcy Ogada, Richard Inger
Although there is a diversity of concerns about recent persistent declines in the abundances of many species, the implications for the associated delivery of ecosystem services to people are surprisingly poorly understood. In principle, there are a broad range of potential functional relationships between the abundance of a species or group of species and the magnitude of ecosystem-service provision. Here, we identify the forms these relationships are most likely to take. Focusing on the case of birds, we review the empirical evidence for these functional relationships, with examples of supporting, regulating, and cultural services...
April 1, 2018: Bioscience
https://www.readbyqxmd.com/read/29674164/impact-of-r152k-and-r368k-neuraminidase-catalytic-substitutions-on-in-vitro-properties-and-virulence-of-recombinant-a-h1n1-pdm09-viruses
#7
Véronique Tu, Yacine Abed, Clément Fage, Mariana Baz, Guy Boivin
Neuraminidase (NA) mutations conferring resistance to NA inhibitors (NAIs) are expected to occur at framework or catalytic residues of the NA enzyme. Numerous clinical and in vitro reports already described NAI-resistant A(H1N1)pdm09 variants harboring various framework NA substitutions. By contrast, variants with NA catalytic changes remain poorly documented. Herein, we investigated the effect of R152K and R368K NA catalytic mutations on the NA enzyme properties, in vitro replicative capacity and virulence of A(H1N1)pdm09 recombinant viruses...
April 16, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29664716/identification-of-carbapenem-resistant-pseudomonas-aeruginosa-in-selected-hospitals-of-the-gulf-cooperation-council-states-dominance-of-high-risk-clones-in-the-region
#8
Hosam M Zowawi, Melanie W Syrmis, Timothy J Kidd, Hanan H Balkhy, Timothy R Walsh, Sameera M Al Johani, Reem Y Al Jindan, Mubarak Alfaresi, Emad Ibrahim, Amina Al-Jardani, Jameela Al Salman, Ali A Dashti, Hanna E Sidjabat, Omar Baz, Ella Trembizki, David M Whiley, David L Paterson
PURPOSE: The molecular epidemiology and resistance mechanisms of carbapenem-resistant Pseudomonas aeruginosa (CRPA) were determined in hospitals in the countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, the United Arab Emirates, Oman, Qatar, Bahrain and Kuwait. METHODOLOGY: Isolates were screened for common carbapenem-resistance genes by PCR. Relatedness between isolates was assessed using previously described genotyping methods: an informative-single nucleotide polymorphism MassARRAY iPLEX assay (iPLEX20SNP) and the enterobacterial repetitive intergenic consensus (ERIC)-PCR assay, with selected isolates being subjected to multilocus sequence typing (MLST)...
April 17, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29625712/contaminants-of-emerging-concern-nicotine-in-wastewater-as-a-public-health-analysis-tool
#9
José Ignacio de Granda-Orive, Carlos de Granda-Beltrán, José Antonio Baz-Lomba
No abstract text is available yet for this article.
April 3, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29624869/a-highly-efficient-near-infrared-emissive-copolymer-with-n-n-double-bond-%C3%AF-conjugated-system-based-on-a-fused-azobenzene-boron-complex
#10
Masayuki Gon, Kazuo Tanaka, Yoshiki Chujo
The fused azobenzene-boron complexes (BAzs) were prepared, and highly-efficient near-infrared (NIR) emission was observed from the nitrogen=nitrogen (N=N) double bond containing π-conjugated copolymer. From the optical measurements, it was found that BAz worked as a strong electron-acceptor originating from intrinsic electron-deficiency of the N=N double bond and the boron-nitrogen (B-N) coordination which dramatically lowered the energy level of the lowest unoccupied molecular orbital (LUMO) of the azobenzene ligand...
April 6, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29622969/relationship-between-serum-osteoprotegerin-and-vascular-calcifications-in-hemodialysis-patients
#11
Tarek Z El Baz, Osama A Khamis, Amal El-Shehaby, Hussein Chahine, Ahmad Alaa Al-Din Ahmed, Mostafa A Alsawasany
Background: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis. Methods: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study...
June 2017: Egypt Heart J
https://www.readbyqxmd.com/read/29621715/comparison-of-phosphodiesterase-type-v-inhibitors-use-in-eight-european-cities-through-analysis-of-urban-wastewater
#12
Ana Causanilles, Daniela Rojas Cantillano, Erik Emke, Richard Bade, Jose Antonio Baz-Lomba, Sara Castiglioni, Erika Castrignanò, Emma Gracia-Lor, Félix Hernández, Barbara Kasprzyk-Hordern, Juliet Kinyua, Ann-Kathrin McCall, Alexander L N van Nuijs, Benedek G Plósz, Pedram Ramin, Nikolaos I Rousis, Yeonsuk Ryu, Kevin V Thomas, Pim de Voogt
In this work a step forward in investigating the use of prescription drugs, namely erectile dysfunction products, at European level was taken by applying the wastewater-based epidemiology approach. 24-h composite samples of untreated wastewater were collected at the entrance of eight wastewater treatment plants serving the catchment within the cities of Bristol, Brussels, Castellón, Copenhagen, Milan, Oslo, Utrecht and Zurich. A validated analytical procedure with direct injection of filtered aliquots by liquid chromatography-tandem mass spectrometry was applied...
April 2, 2018: Environment International
https://www.readbyqxmd.com/read/29606298/effect-of-beta-blocker-dose-on-mortality-after-acute-coronary-syndrome
#13
Sergio Raposeiras-Roubin, Emad Abu-Assi, Berenice Caneiro-Queija, Rafael Cobas-Paz, Lucía Rioboo-Lestón, Cristina García Rodríguez, Cruz Giraldez Lemos, María Blanco Vidal, Beatriz Ogando Guillán, Isabel Pérez Martínez, Emilio Paredes-Galán, Víctor Jimenez-Díaz, Jose Antonio Baz-Alonso, Francisco Calvo-Iglesias, Andrés Íñiguez-Romo
INTRODUCTION: Beta-blocker doses that have been shown to be effective in randomized clinical trials are not commonly used in daily clinical practice. The aim of this study was to analyze whether there is a prognostic benefit of high rather than low doses of beta-blockers after an acute coronary syndrome (ACS). METHODS: In this retrospective cohort study, 2092 ACS patients discharged from hospital between June 2013 and January 2016 were classified according to the beta-blocker dose prescribed: high dose (≥50% of the target dose tested in clinical trials) and low dose (<50%)...
March 30, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29604677/active-nonreciprocal-acoustic-metamaterials-using-a-switching-controller
#14
Amr Baz
A class of active acoustic diodes and metamaterials is developed to control the flow and distribution of acoustic energy in acoustic cavities and systems. Such development departs radically from the currently available approaches where the non-reciprocities are generated by hard-wired designs, favoring one transmission direction which is dictated by the arrangement of the hardware and hence it cannot be reversed, or without the presentation of rigorous control theory analysis. The proposed active nonreciprocal acoustic metamaterial (ANAM) cell consists of a one-dimensional acoustic cavity provided with active flexible boundaries...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29543315/anthropometric-assessment-of-school-children-in-khartoum-locality-khartoum-state-sudan-2014-2015
#15
Eglal E Elrayah, Siham A Balla, Haidar Abu Ahmed
Anthropometric measurements are used to assess growth of children which is affected by different biological and environmental factors. The importance of the period after the first 1000 days of life has been identified in the attempt to restore normal growth and body functions. The objectives of this study are to assess the growth and nutritional status of school children in Khartoum locality, Khartoum State, Sudan and to verify socioeconomic status and sex as factors influencing growth of children. This is a cross-sectional school-based study including 390 children, males and females, of ages between 5-12 years (60-44 months) from private and public schools...
March 15, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29533691/urinary-neutrophil-gelatinase-associated-lipocalin-as-a-marker-for-disease-activity-in-lupus-nephritis
#16
Mohamed S El Shahawy, Mahmoud H Hemida, Hafez A Abdel-Hafez, Tarek Z El-Baz, Abdel-Wahab M Lotfy, Tarek M Emran
The neutrophil gelatinase-associated lipocalin (NGAL) has been emerging as a novel biomarker of acute kidney injury while its value in lupus nephritis is uncertain. The aim of this study was to assess urinary NGAL levels as a marker for disease activity in patients with lupus nephritis.This study included 70 systemic lupus erythematosus (SLE) patients; 50 with active lupus nephritis (LN) and 20 without as well as 20 matched controls. The neutrophil gelatinase-associated lipocalin (NGAL) in both serum and urine samples was measured by enzyme-linked immunosorbent assay (ELISA)...
March 13, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29531170/rigg1-fc-hexamer-inhibits-antibody-mediated-autoimmune-disease-via-effects-on-complement-and-fc%C3%AE-rs
#17
Rolf Spirig, Ian K Campbell, Sandra Koernig, Chao-Guang Chen, Bonnie J B Lewis, Rebecca Butcher, Ineke Muir, Shirley Taylor, Jenny Chia, David Leong, Jason Simmonds, Pierre Scotney, Peter Schmidt, Louis Fabri, Andreas Hofmann, Monika Jordi, Martin O Spycher, Susann Cattepoel, Jennifer Brasseit, Con Panousis, Tony Rowe, Donald R Branch, Adriana Baz Morelli, Fabian Käsermann, Adrian W Zuercher
Activation of Fc receptors and complement by immune complexes is a common important pathogenic trigger in many autoimmune diseases and so blockade of these innate immune pathways may be an attractive target for treatment of immune complex-mediated pathomechanisms. High-dose IVIG is used to treat autoimmune and inflammatory diseases, and several studies demonstrate that the therapeutic effects of IVIG can be recapitulated with the Fc portion. Further, recent data indicate that recombinant multimerized Fc molecules exhibit potent anti-inflammatory properties...
April 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29525724/invasive-versus-conservative-strategy-in-frail-patients-with-nstemi-the-mosca-frail-clinical-trial-study-design
#18
Juan Sanchis, Albert Ariza-Solé, Emad Abu-Assi, Oriol Alegre, Fernando Alfonso, José Antonio Barrabés, José Antonio Baz, Antonio Carol, Pablo Díez Villanueva, Bruno García Del Blanco, Jaime Elízaga, Eduard Fernandez, Abel García Del Egido, Joan García Picard, Iván Gómez Blázquez, Joan Antoni Gómez Hospital, Rosana Hernández-Antolín, Cinta Llibre, Francisco Marín, David Martí Sánchez, Roberto Martín, Manuel Martínez Sellés, Gema Miñana, María José Morales Gallardo, Julio Núñez, Armando Pérez de Prado, Eduardo Pinar, Marcelo Sanmartín, Alessandro Sionis, Adolfo Villa, Jaume Marrugat, Héctor Bueno
INTRODUCTION AND OBJECTIVES: Although clinical guidelines recommend invasive management in non-ST-segment elevation myocardial infarction (NSTEMI), this strategy is underused in frail elderly patients in the real world. Furthermore, these patients are underrepresented in clinical trials and therefore the evidence is scarce. Our hypothesis is that an invasive strategy will improve prognosis in elderly frail patients with NSTEMI. METHODS: This will be a prospective, multicenter, randomized trial, in which the conservative and invasive strategies will be compared in patients meeting all of the following inclusion criteria: NSTEMI diagnosis, age ≥ 70 years, and frailty defined by a category ≥ 4 in the Clinical Frailty Scale...
March 7, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29525582/annual-variation-in-decomposition-and-insect-succession-at-a-periurban-area-of-central-iberian-peninsula
#19
Luisa M Díaz-Aranda, Daniel Martín-Vega, Aída Gómez-Gómez, Blanca Cifrián, Arturo Baz
The variation in decomposition and insect succession among the four seasons of one year was studied for the first time in a periurban area of central Spain. During the winter trial, the carcasses showed corification, a cadaveric preservation phenomenon which apparently leaded to a significant delay in decomposition processes. The composition of the insect fauna breeding on carcasses changed significantly between trials. Active decay was mainly driven by Calliphoridae (Diptera) larvae in every season except in winter trial, when larvae of Thanatophilus species (Coleoptera: Silphidae) were the main consumers of soft tissues...
May 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29525281/a-large-scale-field-randomized-trial-demonstrates-safety-and-efficacy-of-the-vaccine-letifend%C3%A2-against-canine-leishmaniosis
#20
Javier Fernández Cotrina, Virginia Iniesta, Isabel Monroy, Victoria Baz, Christophe Hugnet, Francisco Marañon, Mercedes Fabra, Luis Carlos Gómez-Nieto, Carlos Alonso
Canine leishmaniosis is a zoonotic disease caused by Leishmania infantum. Extensive research is currently ongoing to develop safe and effective vaccines to protect from disease development. The European Commission has granted a marketing authorization for LetiFend®, a new vaccine containing recombinant Protein Q. The efficacy of LetiFend® vaccination in a large-scale dog population of both sexes, different breeds and ages in endemic areas is reported in this multicenter, randomized, double-blind, placebo-controlled field trial...
April 5, 2018: Vaccine
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