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Alexandre Pico-Blanco, Pablo Castelo-Baz, Leticia Caneiro-Queija, Antonio Liñares-González, Pablo Martin-Lancharro, Juan Blanco-Carrión
INTRODUCTION: Teeth affected by combined endodontic-periodontal lesions are usually considered by all prognosis classifications as hopeless teeth. The development of new biomaterials combined with modern endodontic and periodontal regeneration techniques may improve dental prognosis and maintain the affected teeth. Moreover, 1 of the replacement options for those teeth, dental implants, has shown an increasing number of biological and technical complications. METHODS: Five patients were included in this case series study...
October 18, 2016: Journal of Endodontics
Andreas Arendt, El-Sayed Baz, Monika Stengl
The circadian pacemaker of the Madeira cockroach Rhyparobia (Leucophaea) maderae is located in the accessory medulla (AME). Ipsi- and contralateral histaminergic compound eyes are required for photic entrainment. Light pulses delayed locomotor activity rhythms during the early night and advanced during the late night. Thus, different neuronal pathways might relay either light-dependent delays or advances to the clock. Injections of neuroactive substances combined with running-wheel assays suggested that GABA, PDF, myoinhibitory peptides (MIPs), and orcokinins (ORCs) are part of both entrainment pathways, while allatotropin (AT) only delayed locomotor rhythms at the early night...
October 20, 2016: Journal of Comparative Neurology
Salma M Wakil, Ramesh Ram, Nzioka P Muiya, Munish Mehta, Editha Andres, Nejat Mazhar, Batoul Baz, Samya Hagos, Maie Alshahid, Brian F Meyer, Grant Morahan, Nduna Dzimiri
The data shows results acquired in a large cohort of 5668 ethnic Arabs involved in a common variants association study for coronary artery disease (CAD) and myocardial infarction (MI) using the Affymetrix Axiom Genotyping platform ("A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs" Wakil et al. (2015) [1] ). Several loci were described that conferred risk for CAD or MI, some of which were validated in an independent set of samples. Principal Component (PCA) analysis suggested that the Saudi Cohort was close to the CEU and TSI populations, thus pointing to similarity with European populations...
June 2016: Data in Brief
E A Huhn, T Fischer, C S Göbl, M Todesco Bernasconi, M Kreft, M Kunze, A Schoetzau, E Dölzlmüller, W Eppel, P Husslein, N Ochsenbein-Koelble, R Zimmermann, E Bäz, H Prömpeler, E Bruder, S Hahn, I Hoesli
INTRODUCTION: As the accurate diagnosis and treatment of gestational diabetes mellitus (GDM) is of increasing importance; new diagnostic approaches for the assessment of GDM in early pregnancy were recently suggested. We evaluate the diagnostic power of an 'early' oral glucose tolerance test (OGTT) 75 g and glycosylated fibronectin (glyFn) for GDM screening in a normal cohort. METHODS AND ANALYSIS: In a prospective cohort study, 748 singleton pregnancies are recruited in 6 centres in Switzerland, Austria and Germany...
October 12, 2016: BMJ Open
Jose Antonio Baz-Lomba, Stefania Salvatore, Emma Gracia-Lor, Richard Bade, Sara Castiglioni, Erika Castrignanò, Ana Causanilles, Felix Hernandez, Barbara Kasprzyk-Hordern, Juliet Kinyua, Ann-Kathrin McCall, Alexander van Nuijs, Christoph Ort, Benedek G Plósz, Pedram Ramin, Malcolm Reid, Nikolaos I Rousis, Yeonsuk Ryu, Pim de Voogt, Jorgen Bramness, Kevin Thomas
BACKGROUND: Monitoring the scale of pharmaceuticals, illicit and licit drugs consumption is important to assess the needs of law enforcement and public health, and provides more information about the different trends within different countries. Community drug use patterns are usually described by national surveys, sales and seizure data. Wastewater-based epidemiology (WBE) has been shown to be a reliable approach complementing such surveys. METHOD: This study aims to compare and correlate the consumption estimates of pharmaceuticals, illicit drugs, alcohol, nicotine and caffeine from wastewater analysis and other sources of information...
October 1, 2016: BMC Public Health
V Gómez-Vallejo, A Lekuona, Z Baz, B Szczupak, U Cossío, J Llop
A simple, straightforward and efficient method for the synthesis of [(18)F]CF4 and [(18)F]SF6 based on an ion beam-induced isotopic exchange reaction is presented. Positron emission tomography ventilation studies in rodents using [(18)F]CF4 showed a uniform distribution of the radiofluorinated gas within the lungs and rapid elimination after discontinuation of the administration.
September 29, 2016: Chemical Communications: Chem Comm
Ahmed Soliman, Fahmi Khalifa, Ahmed Elnakib, Mohamed Abou El-Ghar, Neal Dunlap, Brian Wang, Georgy Gimel'farb, Robert Keynton, Ayman El-Baz
To accurately segment pathological and healthy lungs for reliable computer-aided disease diagnostics, a stack of chest CT scans is modeled as a sample of a spatially inhomogeneous joint 3D Markov-Gibbs random field (MGRF) of voxel-wise lung and chest CT image signals (intensities). The proposed learnable MGRF integrates two visual appearance sub models with an adaptive lung shape submodel. The first-order appearance submodel accounts for both the original CT image and its Gaussian scale space (GSS) filtered version to specify local and global signal properties, respectively...
September 12, 2016: IEEE Transactions on Medical Imaging
Pablo Castelo-Baz, Purificación Varela-Patiño, Giuseppe Cantatore, Ana Domínguez-Perez, Manuel Ruíz-Piñón, Ramón Miguéns-Vila, Benjamín Martín-Biedma
BACKGROUND: The efficacy of endodontic irrigation procedures can be compromised by the complexity of the root canal system. Delivering irrigants to the apical third of curved canals presents a particular challenge to endodontists. This study compared the effects of two ultrasonic irrigation techniques on the penetration of sodium hypochlorite into the main canal and simulated lateral canals of curved roots in extracted teeth. MATERIAL AND METHODS: Two sets of simulated lateral canals were created at 2, 4, and 6 mm from the working length in 60 single-rooted teeth (6 canals/tooth, n = 360 canals)...
October 2016: Journal of Clinical and Experimental Dentistry
Aqeel Munahi Almutairi, Tahir Ansari, Waqas Sami, Salah Baz
OBJECTIVES: Epilepsy is very common in the Kingdom of Saudi Arabia, occurring in 6.54 out of every 1000 individuals. The current study was conducted to determine the level of public awareness of and attitudes toward epilepsy in the city of Majmaah, Saudi Arabia. SUBJECTS AND METHODS: This descriptive study was conducted in Majmaah, Saudi Arabia. The study population included respondents derived from preselected public places in the city. Stratified random sampling was used, and the sample size was made up of 706 individuals...
October 2016: Journal of Neurosciences in Rural Practice
Silvia Belinchón-Lorenzo, Juan Carlos Parejo, Virginia Iniesta, Javier Fernández-Cotrina, Rubén Muñoz-Madrid, Isabel Monroy, Victoria Baz, Adela Gómez-Luque, Francisco Javier Serrano-Aguilera, José Luis Barneto, Luis Carlos Gómez-Nieto
Nowadays, searching for alternative non-invasive methods for molecular diagnosis of canine visceral leishmaniosis is getting increasingly important. We previously described the presence of Leishmania kinetoplast DNA (kDNA) in canine hair; in this case we hypothesized whether foreign DNA might be present in cerumen of dogs with leishmaniosis, and be detected by Real time quantitative PCR (qPCR). A population of 38 dogs that lived in Leishmania endemic areas was divided in two groups: A (33 dogs with confirmed leishmaniosis by serological techniques) and B (5 healthy dogs)...
September 15, 2016: Veterinary Parasitology
Khalil Ghoussoub, Alain El Asmar, Gaby Kreichati, Sawma Wakim, Mayla Bakhache, Maria Baz, Zakhia Naoum
OBJECTIVE: Our study aims to assess the prevalence and risk factors of low back pain occurred in health care workers in a Lebanese Hospital, and the impact of gestural and postural education in prevention. MATERIAL/PATIENTS AND METHODS: A transversal survey with retrospective data collection was conducted at the University Hospital Center Hôtel-Dieu de France (HDF) Beirut in November 2015. It was based on a questionnaire of 29 items exploring the demographic, anthropometric and social data subjects and data for low back pain: duration, trigger back pain, risk factors, low back pain history, and the role of staff training to handling...
September 2016: Annals of Physical and Rehabilitation Medicine
Laila Hubbert, Jacek Baranowski, Baz Delshad, Henrik Ahn
Following implantation of a continuous-flow left ventricular assist device (LVAD), left atrial pressure (LAP) monitoring allows for precise management of intravascular volume, inotropic therapy and pump speed. In this case series of 4 LVAD recipients we report the first clinical use of this wireless pressure sensor for long-term monitoring of LAP during LVAD support. A wireless microelectromechanical system (MEMS) pressure sensor, (Titan™, ISS Inc., Ypsilanti, MI, USA) was placed in the left atrium in four patients at the time of LVAD implantation...
September 22, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Carlos Rodríguez-Pascual, Emilio Paredes-Galán, Ana Isabel Ferrero-Martínez, José Antonio Baz-Alonso, Darío Durán-Muñoz, Eva González-Babarro, Marcelo Sanmartín, Teresa Parajes, Ivett Torres-Torres, Miguel Piñón-Esteban, Francisco Calvo-Iglesias, Maria Teresa Olcoz-Chiva, Fernando Rodríguez-Artalejo
BACKGROUND: The role of frailty as a prognostic factor in non-selected patients with symptomatic severe aortic stenosis (SAS) is still uncertain. This study aims to examine the association between the frailty syndrome and mortality among very old patients with symptomatic SAS, and to assess whether the association varies with the type of SAS treatment. METHODS AND RESULTS: Prospective study of 606 patients aged ≥75years with symptomatic SAS, recruited from February 2010 to January 2015, who were followed up through June 2015...
September 14, 2016: International Journal of Cardiology
Mahesh Sarki, Aileen Robertson, Alexandr Parlesak
BACKGROUND: The prevalence of childhood overweight and obesity is increasing in low-and middle income countries such as Nepal. At the same time, high prevalence of chronic undernutrition persists leading to a double burden of malnutrition. AIM: To identify associations between the socioeconomic status of mothers, food security, the food safety environment within the household, and prevalence of stunting and overweight of the children. METHODS: Statistical analysis of socioeconomic, food safety-related and anthropometric data from 289 mother-child dyads in an urban area of the Kathmandu Valley, Nepal...
2016: Archives of Public Health, Archives Belges de Santé Publique
Benoit Aigouy, André Le Bivic
The localisation of apico-basal polarity proteins along the Z-axis of epithelial cells is well understood while their distribution in the plane of the epithelium is poorly characterised. Here we provide a systematic description of the planar localisation of apico-basal polarity proteins in the Drosophila ommatidial epithelium. We show that the adherens junction proteins Shotgun and Armadillo, as well as the baso-lateral complexes, are bilateral, i.e. present on both sides of cell interfaces. In contrast, we report that other key adherens junction proteins, Bazooka and the myosin regulatory light chain (Spaghetti squash) are unilateral, i...
2016: Scientific Reports
P C Thomas, L V Marino, S A Williams, R M Beattie
INTRODUCTION: Multiple nutritional risk assessment tools are available, but there are limited data on their application in the acute setting. We explored the validity of two tools in a tertiary Children's Hospital's acute unit and the cohort's nutritional status using WHO definitions. METHODS: Prospective study n=300 (median 38 months; 44.6% female; 25.7% ≤12 months). Participants had standard anthropometry measured, all were screened using the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP), the Paediatric Malnutrition Screening Tool (PMST) (modified STAMP) and 125 were additionally screened using the Paediatric Yorkhill Malnutrition Screening (PYMS) tool...
September 8, 2016: Archives of Disease in Childhood
Ali Bülent Baz, Serdar Akalin, Ömer Faruk Kiliçaslan, Bogaçhan Tokatman, Hasan Arik, Fatih Duygun
Eighty-seven osteoporotic vertebral fractures of 82 patients were treated with balloon kyphoplasty. Preoperative, postoperative and follow-up outcomes of functional impairment, pain scores and vertebral height restorations of the patients were recorded and evaluated statistically. Seventy-two of the patients were female (87.8%) and 10 (12.2%) were male. Mean age of all patients were 66.4 years. Preoperative mean Anterior Vertebral Body Height of 48.20±13.94 % and Middle Vertebral Body Height of 59.40±14.26 % were recorded as 79...
2016: Kobe Journal of Medical Sciences
A Valente, D Silva, E Neves, F Almeida, J L Cruz, C C Dias, A da Costa-Pereira, A Caldas-Afonso, A Guerra
OBJECTIVE: Undernutrition is an important cause of morbidity and mortality in infants and children worldwide. The aim of this study was to evaluate the nutritional status and their predictors in children from 0 to 5 years of age in São Tomé. STUDY DESIGN: A cross-sectional study was conducted in São Tomé Island. METHODS: A total of 1285 individuals were enrolled between January and May 2011. Children were measured, and height for age (HAZ), weight for height (WHZ) and body mass index (BAZ) Z-score were computed...
August 26, 2016: Public Health
Joel G Turner, Jana L Dawson, Steven Grant, Kenneth H Shain, William S Dalton, Yun Dai, Mark Meads, Rachid Baz, Michael Kauffman, Sharon Shacham, Daniel M Sullivan
BACKGROUND: Acquired drug resistance is the greatest obstacle to the successful treatment of multiple myeloma (MM). Despite recent advanced treatment options such as liposomal formulations, proteasome inhibitors, immunomodulatory drugs, myeloma-targeted antibodies, and histone deacetylase inhibitors, MM is still considered an incurable disease. METHODS: We investigated whether the clinical exportin 1 (XPO1) inhibitor selinexor (KPT-330), when combined with pegylated liposomal doxorubicin (PLD) or doxorubicin hydrochloride, could overcome acquired drug resistance in multidrug-resistant human MM xenograft tumors, four different multidrug-resistant MM cell lines, or ex vivo MM biopsies from relapsed/refractory patients...
2016: Journal of Hematology & Oncology
Erika V Soriano, Marina E Ivanova, Georgina Fletcher, Philippe Riou, Philip P Knowles, Karin Barnouin, Andrew Purkiss, Brenda Kostelecky, Peter Saiu, Mark Linch, Ahmed Elbediwy, Svend Kjær, Nicola O'Reilly, Ambrosius P Snijders, Peter J Parker, Barry J Thompson, Neil Q McDonald
Atypical protein kinase C (aPKC) is a key apical-basal polarity determinant and Par complex component. It is recruited by Par3/Baz (Bazooka in Drosophila) into epithelial apical domains through high-affinity interaction. Paradoxically, aPKC also phosphorylates Par3/Baz, provoking its relocalization to adherens junctions (AJs). We show that Par3 conserved region 3 (CR3) forms a tight inhibitory complex with a primed aPKC kinase domain, blocking substrate access. A CR3 motif flanking its PKC consensus site disrupts the aPKC kinase N lobe, separating P-loop/αB/αC contacts...
August 22, 2016: Developmental Cell
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