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https://www.readbyqxmd.com/read/28209315/impact-of-apoe-genotypes-variations-on-toxoplasma-patients-with-dementia
#1
Raida S Yahya, Soha I Awad, Hatim A El-Baz, Niveen Saudy, Osama A Abdelsalam, Mohamed S Shehab Al-Din
BACKGROUND: Toxoplasma deprives host neuron cells from cholesterol and leads to its ability to potentiate dementia. ApoE intermediates neuronal transmission of cholesterol, which is a key constituent for axonal development, redesigning occasions that are important for education and synaptic arrangement, development of memory and repair of neuron. The aim of this work is to investigate the effect of ApoE genotypes on dementia associated with neurodegeneration in latent Toxoplasma gondii in elderly population...
February 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28199957/targeting-kv7-channels-in-pain-pathways
#2
EDITORIAL
Ivan Rivera-Arconada, Jorge Vicente-Baz, Jose Antonio Lopez-Garcia
No abstract text is available yet for this article.
February 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28170032/effect-of-repeated-vaccination-with-the-same-vaccine-component-against-influenza-a-h1n1-pdm09
#3
Iván Martínez-Baz, Itziar Casado, Ana Navascués, Jorge Díaz-González, Aitziber Aguinaga, Laura Barrado, Josu Delfrade, Carmen Ezpeleta, Jesús Castilla
No abstract text is available yet for this article.
February 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28167003/visual-speech-alters-the-discrimination-and-identification-of-non-intact-auditory-speech-in-children-with-hearing-loss
#4
Susan Jerger, Markus F Damian, Rachel P McAlpine, Hervé Abdi
OBJECTIVES: Understanding spoken language is an audiovisual event that depends critically on the ability to discriminate and identify phonemes yet we have little evidence about the role of early auditory experience and visual speech on the development of these fundamental perceptual skills. Objectives of this research were to determine 1) how visual speech influences phoneme discrimination and identification; 2) whether visual speech influences these two processes in a like manner, such that discrimination predicts identification; and 3) how the degree of hearing loss affects this relationship...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28166417/detection-of-microspheres-in-vivo-using-multispectral-optoacoustic-tomography
#5
N Bhutiani, C W Kimbrough, N C Burton, S Morscher, M Egger, K McMasters, A Woloszynska-Read, A El-Baz, L R McNally
We introduce a new approach to detect individual microparticles that contain NIR fluorescent dye by multispectral optoacoustic tomography in the context of the hemoglobin-rich environment within murine liver. We encapsulated a near infrared (NIR) fluorescent dye within polystyrene microspheres, then injected them into the ileocolic vein, which drains to the liver. NIR absorption was determined using multispectral optoacoustic tomography. To quantitate the minimum diameter of microspheres, we used both colorimetric and spatial information to segment the regions in which the microspheres appear...
February 6, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28148680/the-plasma-proteome-is-associated-with-anthropometric-status-of-undernourished-nepalese-school-aged-children
#6
Sun Eun Lee, Christine P Stewart, Kerry J Schulze, Robert N Cole, Lee S-F Wu, James D Yager, John D Groopman, Subarna K Khatry, Ramesh Kant Adhikari, Parul Christian, Keith P West
BACKGROUND: Malnutrition affects body growth, size, and composition of children. Yet, few functional biomarkers are known to be associated with childhood morphology. OBJECTIVE: This cross-sectional study examined associations of anthropometric indicators of height, musculature, and fat mass with plasma proteins by using proteomics in a population cohort of school-aged Nepalese children. METHODS: Height, weight, midupper arm circumference (MUAC), triceps and subscapular skinfolds, upper arm muscle area (AMA), and arm fat area (AFA) were assessed in 500 children 6-8 y of age...
February 1, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28127367/intestinal-parasitic-infections-and-nutritional-status-among-primary-school-children-in-delo-mena-district-south-eastern-ethiopia
#7
Begna Tulu, Solomon Taye, Yohannes Zenebe, Eden Amsalu
BACKGROUND: Although there are efforts being underway to control and prevent intestinal parasitic infections (IPIs) in Ethiopia, they are still endemic and responsible for significant morbidity. The aim of this study was to evaluate the prevalence of IPIs and their association with nutritional status among primary school children of Delo-Mena district, South Eastern Ethiopia. METHODS: A cross-sectional study was conducted from April to May 2013. Demographic data was obtained, and IPIs was investigated in a single-stool sample by both direct stool examination and formol-ether concentration techniques...
October 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28124089/evening-primrose-oil-or-forskolin-ameliorates-celecoxib-enhanced-upregulation-of-tissue-factor-expression-in-mice-subjected-to-lipopolysaccharide-induced-endotoxemia
#8
Sarah M Mosaad, Sawsan A Zaitone, Amal A M Ahmed, Dina M Abo-Elmatty, Amani A El-Baz, Yasser M Moustafa
Celecoxib, a selective cyclooxygenase-2 inhibitor, produces thrombotic events in patients predisposed to cardiovascular risk factors. One theory reported an increase in endothelial expression of tissue factor (TF) as a predisposing factor. This work explored the effect of evening primrose oil (EPO), a source of prostaglandin E1, and forskolin (a cyclic adenosine monophosphate stimulator) against the prothrombotic effect of celecoxib in mice. Lipopolysaccharide mouse model of endotoxemia was used to induce an upregulation of TF activity...
January 26, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28113657/accurate-lungs-segmentation-on-ct-chest-images-by-adaptive-appearance-guided-shape-modeling
#9
Ahmed Soliman, Fahmi Khalifa, Ahmed Elnakib, Mohamed Abou El-Ghar, Neal Dunlap, Brian Wang, Georgy Gimel'farb, Robert Keynton, Ayman El-Baz
To accurately segment pathological and healthy lungs for reliable computer-aided disease diagnostics, a stack of chest CT scans is modeled as a sample of a spatially inhomogeneous joint 3D Markov-Gibbs random field (MGRF) of voxel-wise lung and chest CT image signals (intensities). The proposed learnable MGRF integrates two visual appearance sub models with an adaptive lung shape submodel. The first-order appearance submodel accounts for both the original CT image and its Gaussian scale space (GSS) filtered version to specify local and global signal properties, respectively...
September 12, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28110858/-the-prevalence-of-diagnosed-and-undiagnosed-hepatitis-c-virus-infection-in-navarra-spain-2014-2016
#10
Aitziber Aguinaga, Jorge Díaz-González, Alejandra Pérez-García, Laura Barrado, Iván Martínez-Baz, Itziar Casado, Regina Juanbeltz, Carmen Ezpeleta, Jesús Castilla
OBJECTIVE: To estimate the prevalence of hepatitis C virus (HCV) infection in Navarra, Spain, as well as to distinguish between diagnosed and undiagnosed infections. METHODS: A study was conducted on patients scheduled for surgery unrelated to HCV infection. They were all tested for HCV antibodies, under a routine scheme, from January 2014 to September 2016. Patients with a positive result by enzyme immunoassay were confirmed using immunoblot and/or HCV-RNA. Previous laboratory results were also taken into account...
January 19, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28098103/relation-of-fibroblast-growth-factor-23-and-cardiovascular-calcification-in-end-stage-kidney-disease-patients-on-regular-hemodialysis
#11
Tarek Zakaria El Baz, Osama Ahmed Khamis, Osama Ashry Ahmed Gheith, Salama Saad Abd Ellateif, Abdallah Mahmoud Abdallah, Hussein Chahine Abd El Aal
More than half of deaths in end-stage kidney disease (ESKD) patients are due to cardiovascular disease. Elevated fibroblast growth factor 23 (FGF-23) was found to be associated with mortality in hemodialysis (HD) patients and correlates with peripheral calcification. Aortic calcification is associated with coronary artery calcification. Both aortic and peripheral vascular calcifications were associated with mortality in chronic kidney disease. We aimed to investigate the relation between intact FGF-23 and cardiovascular calcification in patients with ESKD who were maintained on regular HD...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28073829/dutpase-dut-is-mutated-in-a-novel-monogenic-syndrome-with-diabetes-and-bone-marrow-failure
#12
Reinaldo Sousa Dos Santos, Mathilde Daures, Anne Philippi, Sophie Romero, Lorella Marselli, Piero Marchetti, Valérie Senée, Delphine Bacq, Céline Besse, Baz Baz, Laura Marroquí, Sarah Ivanoff, Julien Masliah-Planchon, Marc Nicolino, Jean Soulier, Gérard Socié, Decio L Eizirik, Jean-François Gautier, Cécile Julier
We describe a new syndrome characterized by early onset diabetes mellitus, associated with bone marrow failure affecting mostly the erythrocytic lineage. Using whole exome sequencing in a remotely consanguineous patient from a family with two affected siblings, we identified a single homozygous missense mutation (chr15.hg19:g.48,626,619A>G) located in the dUTPase (DUT) gene (NCBI Gene ID: 1854), affecting both the mitochondrial (DUT-M p.Y142C) and the nuclear (DUT-N p.Y54C) isoforms. We found the same homozygous mutation in an unrelated consanguineous patient with diabetes and bone marrow aplasia from a family with two affected siblings, while none of the >60,000 subjects from the Exome Aggregation Consortium (ExAC) was homozygous for this mutation...
January 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28063874/polarity-protein-par3-bazooka-follows-myosin-dependent-junction-repositioning
#13
Mo Weng, Eric Wieschaus
The polarity protein Par3/Bazooka (Baz) has been established as a central component of the apical basal polarity system that determines the position of cell-cell junctions in epithelial cells. Consistent with that view, we show that shortly before gastrulation in Drosophila, Baz protein in the mesoderm is down-regulated from junctional sites in response to Snail (Sna) expression. This down-regulation leads to a specific decrease in adherens junctions without affecting other E-Cadherin pools. However, we further show that, interactions between Baz and junctions are not unidirectional...
February 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28063376/a-comprehensive-non-invasive-framework-for-diagnosing-prostate-cancer
#14
Islam Reda, Ahmed Shalaby, Mohammed Elmogy, Ahmed Abou Elfotouh, Fahmi Khalifa, Mohamed Abou El-Ghar, Ehsan Hosseini-Asl, Georgy Gimel'farb, Naoufel Werghi, Ayman El-Baz
Early detection of prostate cancer increases chances of patients' survival. Our automated non-invasive system for computer-aided diagnosis (CAD) of prostate cancer segments the prostate on diffusion-weighted magnetic resonance images (DW-MRI) acquired at different b-values, estimates its apparent diffusion coefficients (ADC), and classifies their descriptors - empirical cumulative distribution functions (CDF) - with a trained deep learning network. To segment the prostate, an evolving geometric (level-set-based) deformable model is guided by a speed function depending on intensity attributes extracted from the DW-MRI with nonnegative matrix factorization (NMF)...
February 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28058164/the-efficacy-of-intravitreal-bevacizumab-in-vitreous-hemorrhage-of-diabetic-subjects
#15
Cengiz Alagöz, Yusuf Yıldırım, Murat Kocamaz, Ökkeş Baz, Uğur Çiçek, Burcu Çelik, Halil İbrahim Demirkale, Ahmet Taylan Yazıcı, Muhittin Taşkapılı
OBJECTIVES: To evaluate the efficacy of intravitreal bevacizumab (IVB) in the resolution of vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR). MATERIALS AND METHODS: Seventy eyes of 70 patients (43 male, mean age 55.6±12.2 years) diagnosed with VH secondary to PDR were evaluated retrospectively. Demographic characteristics of the patients, baseline and final clinical results, and the interventions the patients were subject to were recorded...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28027671/nutrition-status-of-primary-school-students-in-two-rural-regions-of-guinea-bissau
#16
Edward Saltzman, Nina Schlossman, Carrie A Brown, Ionela Balan, Paul Fuss, Payal Batra, Augusto Braima de Sa, Mary Kyla Shea, William M Pruzensky, Carlito Bale, Susan B Roberts
BACKGROUND: The nutrition status of primary schoolchildren in Africa has received relatively little attention in comparison to that of younger children. We surveyed primary school students in Guinea-Bissau, a nation that is among the poorest in the world. OBJECTIVE: Anthropometry and prevalence of anemia and vitamin A deficiency were assessed in schoolchildren participating in International Partnership for Human Development's school feeding program in 2 regions of Guinea-Bissau...
January 1, 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28026713/a-family-centered-lifestyle-intervention-for-obese-six-to-eight-year-old-children-results-from-a-one-year-randomized-controlled-trial-conducted-in-montreal-canada
#17
Tamara R Cohen, Tom J Hazell, Catherine A Vanstone, Celia Rodd, Hope A Weiler
OBJECTIVES: Childhood obesity interventions should be family-centered and focused on lifestyle behaviours that achieve sustainable reductions in adiposity. The primary objective of this randomized controlled trial was to test a family-centered lifestyle intervention using Canada's Food and Physical Activity (PA) Guidelines to reduce body mass index-for-age z-scores (BAZ) in overweight and obese (OW/OB) children. METHODS: Children (n = 78; ages 6-8.5 years) were randomized to standard (StnTx) or modified (ModTx) interventions or control (Ctrl)...
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28018534/does-psychological-safety-impact-the-clinical-learning-environment-for-resident-physicians-results-from-the-va-s-learners-perceptions-survey
#18
Karina D Torralba, Lawrence K Loo, John M Byrne, Samuel Baz, Grant W Cannon, Sheri A Keitz, Annie B Wicker, Steven S Henley, T Michael Kashner
BACKGROUND : Psychological safety (PS) is the perception that it is safe to take interpersonal risks in the work environment. In teaching hospitals, PS may influence the clinical learning environment for trainees. OBJECTIVE : We assessed whether resident physicians believe they are psychologically safe, and if PS is associated with how they rate satisfaction with their clinical learning experience. METHODS : Data were extracted from the Learners' Perceptions Survey (LPS) of residents who rotated through a Department of Veterans Affairs health care facility for academic years 2011-2014...
December 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28017335/two-decades-of-lung-retransplantation-a-single-center-experience
#19
David J Hall, Erol V Belli, Jon A Gregg, Juan C Salgado, Maher A Baz, E Denmark Staples, Thomas M Beaver, Tiago N Machuca
BACKGROUND: Lung retransplantation (ReTx) comprises an increasing share of lung transplants and recently has shown improved outcomes. The aim of this study was to identify risk factors affecting overall survival after pulmonary ReTx. METHODS: The United Network for Organ Sharing database was used to identify patients undergoing lung transplantation at our institution from 1995 to 2014. Of the total 542 lung transplants performed, 87 (16.1%) were ReTxs. The primary outcome was overall survival...
December 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28012556/-crossed-renal-ectopia-in-a-patient-with-a-complicated-sigma-neoplasia
#20
Luis Eduardo Pérez-Sánchez, Mauricio Burneo-Esteves, Adriá Rosat-Rodrigo, Caleb Baz-Figueroa, Antonio Dámaso Pérez-Álvarez, Manuel Ángel Barrera-Gómez
BACKGROUND: Crossed renal ectopia is a rare pathology that is often asymptomatic. Intraoperative detection with a sigma complicated neoplasia is more infrequent and requires correct management to avoid a renal ureteral injury. AIM: To present a case report of a patient with a sigma complicated neoplasia and a crossed renal ectopia detected incidentally. CASE REPORT: We present the case of a 62-year-old man that was submitted for emergency surgery for a sigma perforated neoplasm, and who presented with a previously undiagnosed left-side CRE...
December 21, 2016: Cirugia y Cirujanos
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