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Naser Khan, Sarosh Bukhari, Asif Lakha, Baseer Qaz, Nancy Davis, Alan B Shapiro, Hymie Kavin
PURPOSE: Gastroesophageal reflux disease (GERD) affects up to 25% of the western population, and the annual expenditure for managing GERD is estimated to be more than $14 billion. Most GERD patients do not consult a specialist, but rather rely on their primary care physician for symptom management. Research has shown that many patients--regardless of diagnosis--do not fully understand what their doctors tell them and remain uncertain as to what they are supposed to do to take care of themselves...
December 2013: Journal of Family Practice
Oliver Hucke, René Coulombe, Pierre Bonneau, Mégan Bertrand-Laperle, Christian Brochu, James Gillard, Marc-André Joly, Serge Landry, Olivier Lepage, Montse Llinàs-Brunet, Marc Pesant, Martin Poirier, Maude Poirier, Ginette McKercher, Martin Marquis, George Kukolj, Pierre L Beaulieu, Timothy A Stammers
The design and preliminary SAR of a new series of 1H-quinazolin-4-one (QAZ) allosteric HCV NS5B thumb pocket 2 (TP-2) inhibitors was recently reported. To support optimization efforts, a molecular dynamics (MD) based modeling workflow was implemented, providing information on QAZ binding interactions with NS5B. This approach predicted a small but critical ligand-binding induced movement of a protein backbone region which increases the pocket size and improves access to the backbone carbonyl groups of Val 494 and Pro 495...
March 13, 2014: Journal of Medicinal Chemistry
R Scott Miller, Chansuda Wongsrichanalai, Nillawan Buathong, Philip McDaniel, Douglas S Walsh, Charles Knirsch, Colin Ohrt
Azithromycin, the most potent antimalarial macrolide antibiotic, is synergistic with quinine against Plasmodium falciparum in vitro. We assessed combinations of azithromycin and quinine against uncomplicated P. falciparum malaria at the Armed Forces Research Institute of Medical Sciences-Kwai River Clinical Center along the Thailand-Myanmar border, an area with a high prevalence of multidrug-resistant P. falciparum. Four regimens were assessed in an open-label dose-ranging design involving 61 volunteers. All received oral quinine (Q; 30 mg/kg/day divided every 8 hours for 3 days) with oral azithromycin (Az; 500 mg twice a day for 3 days, 500 mg twice a day for 5 days, or 500 mg three times a day for 3 days)...
March 2006: American Journal of Tropical Medicine and Hygiene
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