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https://www.readbyqxmd.com/read/28644984/current-practice-and-recommendations-in-uk-epilepsy-monitoring-units-report-of-a-national-survey-and-workshop
#1
Khalid Hamandi, Sandor Beniczky, Beate Diehl, Rosalind H Kandler, Ronit M Pressler, Arjune Sen, Juliet Solomon, Matthew C Walker, Manny Bagary
PURPOSE: Inpatient video-EEG monitoring (VEM) is an important investigation in patients with seizures or blackouts, and in the pre-surgical workup of patients with epilepsy. There has been an expansion in the number of Epilepsy Monitoring Units (EMU) in the UK offering VEM with a necessary increase in attention on quality and safety. Previous surveys have shown variation across centres on issues including consent and patient monitoring. METHOD: In an effort to bring together healthcare professionals in the UK managing patients on EMU, we conducted an online survey of current VEM practice and held a one-day workshop convened under the auspices of the British Chapter of the ILAE...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28644656/entanglement-enhanced-phase-estimation-without-prior-phase-information
#2
G Colangelo, F Martin Ciurana, G Puentes, M W Mitchell, R J Sewell
We study the generation of planar quantum squeezed (PQS) states by quantum nondemolition (QND) measurement of an ensemble of ^{87}Rb atoms with a Poisson distributed atom number. Precise calibration of the QND measurement allows us to infer the conditional covariance matrix describing the F_{y} and F_{z} components of the PQS states, revealing the dual squeezing characteristic of PQS states. PQS states have been proposed for single-shot phase estimation without prior knowledge of the likely values of the phase...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644395/optical-tracking-and-digital-quantification-of-beating-behavior-in-bioengineered-human-cardiac-organoids
#3
Mahesh Devarasetty, Steven Forsythe, Thomas D Shupe, Shay Soker, Colin E Bishop, Anthony Atala, Aleksander Skardal
Organoid and organ-on-a-chip technologies are rapidly advancing towards deployment for drug and toxicology screening applications. Liver and cardiac toxicities account for the majority of drug candidate failures in human trials. Liver toxicity generally produces liver cell death, while cardiac toxicity causes adverse changes in heart beat kinetics. In traditional 2D cultures, beating kinetics can be measured by electrode arrays, but in some 3D constructs, quantifying beating kinetics can be more challenging...
June 23, 2017: Biosensors
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#4
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28643695/highly-fluorescent-and-superparamagnetic-nanosystem-for-biomedical-applications
#5
Mariana P Cabrera, Paulo E Cabral Filho, Camila M C M Silva, Rita M Oliveira, Carlos F G C Geraldes, M Margarida C A Castro, Benilde F O Costa, Marta S C Henriques, José A Paixão, Luiz B Carvalho, Beate S Santos, Fernando Hallwass, Adriana Fontes, Giovannia A L Pereira
This work reports on highly fluorescent and superparamagnetic bimodal nanoparticles (BNPs) obtained by a simple and efficient method as probes for fluorescence analysis and/or contrast agents for MRI. These promising BNPs with small dimensions (ca. 17 nm) consist of superparamagnetic iron oxide nanoparticles (SPIONs) covalently bound with CdTe quantum dots (ca. 3 nm). The chemical structure of the magnetic part of BNPs is predominantly magnetite, with minor goethite and maghemite contributions, as shown by Mössbauer spectroscopy, which is compatible with the x-ray diffraction data...
July 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28643583/hemodynamic-stability-during-laryngeal-electromyography-procedures
#6
Yi-An Lu, Yu-Cheng Pei, Alice Mk Wong, Hui-Chen Chiang, Tuan-Jen Fang
BACKGROUND: Laryngeal electromyography (LEMG) is accepted as safe, with minimal side effects. However, patient hemodynamic stability, during these procedures, has not been reported. This study aimed to investigate the hemodynamics in patients undergoing LEMG and determine the risk factors for hemodynamic changes. METHODS: We recruited 89 consecutive patients who underwent LEMG. Baseline and postprocedural changes in vital signs were analyzed. RESULTS: Diastolic blood pressure (DBP) increased from 75...
June 23, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28642714/comparative-effectiveness-of-acupuncture-and-antiarrhythmic-drugs-for-the-prevention-of-cardiac-arrhythmias-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Yanda Li, Hector Barajas-Martinez, Bo Li, Yonghong Gao, Zhenpeng Zhang, Hongcai Shang, Yanwei Xing, Dan Hu
Introduction and Objectives: This study was designed to systematically evaluate the effectiveness of acupuncture treatment for arrhythmia compared to existing drug therapy. Methods: Randomized controlled trials (RCTs) were identified through searches of the MEDLINE, CNKI, Embase, and Cochrane databases (1970 through 2016) and hand searches of cross-references from original articles and reviews. Clinical trials that randomized arrhythmia patients to acupuncture therapy vs. conventional drugs, sham acupuncture, or bed rest were included for analysis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28642293/random-squat-stand-maneuvers-a-novel-approach-for-assessment-of-dynamic-cerebral-autoregulation
#8
Sam C Barnes, Naomi Ball, Victoria Joanna Haunton, Ronney B Panerai, Thompson G Robinson
BACKGROUND: Squat-stand maneuvers (SSM) have been used to assess dynamic cerebral autoregulation (dCA), but always at a fixed-frequency (FF). This study aimed to assess the use of random-frequency (RF) SSMs as a stimulus for measuring dCA, and to determine the reproducibility of FF and RFSSMs. METHOD: 29 healthy volunteers (19 male, mean age 23.0 [4.9] years) completed the study; 11 returned for a repeat visit (median 45 days). Heart rate, beat-to-beat blood pressure, middle cerebral artery (MCA) blood flow velocity, end-tidal CO2 and angle of the squat movement were measured...
June 22, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28640864/targeting-breast-cancer-cells-by-mrs1477-a-positive-allosteric-modulator-of-trpv1-channels
#9
Mustafa Nazıroğlu, Bilal Çiğ, Walter Blum, Csaba Vizler, Andrea Buhala, Annamária Marton, Róbert Katona, Katalin Jósvay, Beat Schwaller, Zoltán Oláh, László Pecze
There is convincing epidemiological and experimental evidence that capsaicin, a potent natural transient receptor potential cation channel vanilloid member 1 (TRPV1) agonist, has anticancer activity. However, capsaicin cannot be given systemically in large doses, because of its induction of acute pain and neurological inflammation. MRS1477, a dihydropyridine derivative acts as a positive allosteric modulator of TRPV1, if added together with capsaicin, but is ineffective, if given alone. Addition of MRS1477 evoked Ca2+ signals in MCF7 breast cancer cells, but not in primary breast epithelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28640847/heart-rate-lowering-treatment-leads-to-a-reduction-in-vulnerable-plaque-features-in-atherosclerotic-rabbits
#10
Raf H M van Hoof, Evelien Hermeling, Judith C Sluimer, Julie Salzmann, Arnold P G Hoeks, Jérôme Roussel, Mat J A P Daemen, Harry Struijker-Boudier, Joachim E Wildberger, Sylvia Heeneman, M Eline Kooi
OBJECTIVE: To investigate the effect of a heart rate (HR) lowering agent (Ivabradine) on features of atherosclerotic plaque vulnerability with magnetic resonance imaging (MRI), ultrasound imaging, and histology. APPROACH AND RESULTS: Atherosclerosis was induced in the abdominal aorta of 19 rabbits. Nine rabbits were treated with Ivabradine (17 mg/kg/day) during the entire study period. At week 14, imaging was performed. Plaque size was quantified on contrast-enhanced T1-weighted MR images...
2017: PloS One
https://www.readbyqxmd.com/read/28640756/single-lead-f-wave-extraction-using-diffusion-geometry
#11
John Malik, Neil Reed, Chun-Li Wang, Hau-Tieng Wu
OBJECTIVE: A novel single-lead f-wave extraction algorithm based on the modern diffusion geometry data analysis framework is proposed. APPROACH: The algorithm is essentially an averaged beat subtraction algorithm, where the ventricular activity template is estimated by combining a newly designed metric, the 'diffusion distance', and the non-local Euclidean median based on the non-linear manifold setup. We coined the algorithm [Formula: see text]. MAIN RESULTS: Two simulation schemes are considered, and the new algorithm [Formula: see text] outperforms traditional algorithms, including the average beat subtraction, principal component analysis, and adaptive singular value cancellation, in different evaluation metrics with statistical significance...
June 22, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28640751/false-spectra-formation-in-the-differential-two-channel-scheme-of-the-laser-doppler-flowmeter
#12
Denis Lapitan, Dmitry Rogatkin, Saydulla Persheyev, Konstantin Kotliar
Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise.
June 22, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28640248/voluntary-distance-running-prevents-tnf-mediated-liver-injury-in-mice-through-alterations-of-the-intrahepatic-immune-milieu
#13
Yvonne Huber, Nadine Gehrke, Jana Biedenbach, Susanne Helmig, Perikles Simon, Beate K Straub, Ina Bergheim, Tobias Huber, Detlef Schuppan, Peter R Galle, Marcus A Wörns, Marcus Schuchmann, Jörn M Schattenberg
Physical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, the role of physical activity in acute liver injury is poorly explored. To study the role of physical activity in acute liver injury, a novel model of voluntary distance running in mice was developed and mice were subjected to acute liver injury induced by N-galactosamine (GalN) and lipopolysaccharide (LPS). Analyses included histological stains, immunoblotting, qRT-PCR and FACS analysis...
June 22, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28639947/surface-electrocardiogram-could-atrioventricular-nodal-and-his-bundle-potentials-be-recorded-beat-by-beat-on-saah-electrocardiogram
#14
Qinghua Chang, Renguang Liu, Juan Chen
OBJECTIVE: The P-QRS-T wave on surface electrocardiogram (ECG) reflects the changes in atrial and ventricular electrical properties. However, the atrioventricular conduction system potentials cannot be recorded to date. This study aimed to explore the possibility of micropotential of the atrioventricular conduction system recorded by surface "SAN-Atrial-AVN-His (Saah) ECG." METHODS: We randomized 100 healthy volunteers (50 females and 50 males; mean age 25.12±1...
June 22, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28639720/isophthalic-acid-based-hdac-inhibitors-as-potent-inhibitors-of-hdac8-from-schistosoma-mansoni
#15
Katharina Stenzel, Alokta Chakrabarti, Jelena Melesina, Finn K Hansen, Julien Lancelot, Simon Herkenhöhner, Beate Lungerich, Martin Marek, Christophe Romier, Raymond J Pierce, Wolfgang Sippl, Manfred Jung, Thomas Kurz
Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has been recently identified as a new potential target for the treatment of schistosomiasis. A series of newly designed and synthesized alkoxyamide-based and hydrazide-based HDAC inhibitors were tested for inhibitory activity against SmHDAC8 and human HDACs 1, 6, and 8. The front runner compounds showed submicromolar activity against SmHDAC8 and modest preference for SmHDAC8 over its human orthologue hHDAC8. Docking studies provided insights into the putative binding mode in SmHDAC8 and allowed rationalization of the observed selectivity profile...
June 22, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28639400/motion-estimation-for-cardiac-functional-analysis-using-two-x-ray-computed-tomography-scans
#16
George S K Fung, Luisa Ciuffo, Hiroshi Ashikaga, Katsuyuki Taguchi
PURPOSE: This work concerns computed tomography (CT)-based cardiac functional analysis (CFA) with a reduced radiation dose. As CT-CFA requires images over the entire heartbeat, the scans are often performed at 10-20% of the tube current settings that are typically used for coronary CT angiography. A large image noise then degrades the accuracy of motion estimation. Moreover, even if the scan was performed during the sinus rhythm, the cardiac motion observed in CT images may not be cyclic with patients with atrial fibrillation...
June 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28639236/the-effects-of-intranasal-dexmedetomidine-premedication-in-children-a-systematic-review-and-meta-analysis
#17
Jong Hun Jun, Kyu Nam Kim, Ji Yoon Kim, Shin Me Song
PURPOSE: Intranasal dexmedetomidine premedication is a newly introduced method for reducing stress and anxiety before general anesthesia in children. We performed a meta-analysis to identify the effects of intranasal dexmedetomidine premedication in children. SOURCE: We conducted a systematic review to find published randomized-controlled trials using intranasal dexmedetomidine as premedication. We searched databases in EMBASE™, MEDLINE®, and the Cochrane Controlled Trials Register using the Ovid platform...
June 21, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28637897/heritability-of-resting-heart-rate-and-association-with-mortality-in-middle-aged-and-elderly-twins
#18
Magnus T Jensen, Mette Wod, Søren Galatius, Jacob B Hjelmborg, Gorm B Jensen, Kaare Christensen
OBJECTIVE: Resting heart rate (RHR) possibly has a hereditary component and is associated with longevity. We used the classical biometric twin study design to investigate the heritability of RHR in a population of middle-aged and elderly twins and, furthermore, studied the association between RHR and mortality. METHODS: In total, 4282 twins without cardiovascular disease were included from the Danish Twin Registry, hereof 1233 twin pairs and 1816 'single twins' (twins with a non-participating co-twin); mean age 61...
June 21, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28637765/electrostatic-interaction-between-polyglutamylated-tubulin-and-the-nexin-dynein-regulatory-complex-regulates-flagellar-motility
#19
Tomohiro Kubo, Toshiyuki Oda
Tubulins undergo various posttranslational modifications. Among them, polyglutamylation is involved in the motility of eukaryotic flagella and the stability of the axonemal microtubules. However, it remains unclear where polyglutamylated tubulin localizes precisely within the axoneme, and how tubulin polyglutamylation affects the flagellar motility. In this study, we identified the three-dimensional (3D) localization of the polyglutamylated tubulin in Chlamydomonas flagella using antibody labeling and cryo-electron tomography...
June 21, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28637705/light-exercise-heart-rate-on-kinetics-a-comparison-of-data-fitted-with-sigmoidal-and-exponential-functions-and-the-impact-of-fitness-and-exercise-intensity
#20
Karl M Trounson, Spencer Roberts, Aaron Balloch, Stuart A Warmington
This study examined the suitability of sigmoidal (SIG) and exponential (EXP) functions for modeling HR kinetics at the onset of a 5-min low-intensity cycling ergometer exercise test (5MT). The effects of training status, absolute and relative workloads, and high versus low workloads on the accuracy and reliability of these functions were also examined. Untrained participants (UTabs; n = 13) performed 5MTs at 100W. One group of trained participants (n = 10) also performed 5MTs at 100W (ETabs). Another group of trained participants (n = 9) performed 5MTs at 45% and 60% V˙O2 max (ET45 and ET60, respectively)...
June 2017: Physiological Reports
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