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https://www.readbyqxmd.com/read/29353197/bioanalytical-assessment-of-adaptive-stress-responses-in-drinking-water-a-predictive-tool-to-differentiate-between-micropollutants-and-disinfection-by-products
#1
Armelle Hebert, Cedric Feliers, Caroline Lecarpentier, Peta A Neale, Rita Schlichting, Sylvie Thibert, Beate I Escher
Drinking water can contain low levels of micropollutants, as well as disinfection by-products (DBPs) that form from the reaction of disinfectants with organic and inorganic matter in water. Due to the complex mixture of trace chemicals in drinking water, targeted chemical analysis alone is not sufficient for monitoring. The current study aimed to apply in vitro bioassays indicative of adaptive stress responses to monitor the toxicological profiles and the formation of DBPs in three drinking water distribution systems in France...
January 3, 2018: Water Research
https://www.readbyqxmd.com/read/29352564/optical-metabolic-imaging-of-irradiated-rat-heart-exposed-to-ischemia-reperfusion-injury
#2
Mette Funding la Cour, Shima Mehrvar, James S Heisner, Mohammad Masoudi Motlagh, Meetha Medhora, Mahsa Ranji, Amadou K S Camara
Whole thoracic irradiation (WTI) is known to cause deterioration in cardiac function. Whether irradiation predisposes the heart to further ischemia and reperfusion (IR) injury is not well known. The aim of this study is to examine the susceptibility of rat hearts to IR injury following a single fraction of 15 Gy WTI and to investigate the role of mitochondrial metabolism in the differential susceptibility to IR injury. After day 35 of irradiation, ex vivo hearts from irradiated and nonirradiated rats (controls) were exposed to 25-min global ischemia followed by 60-min IR, or hearts were perfused without IR for the same protocol duration [time controls (TC)]...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29352099/smoking-and-parkinson-disease-evidence-for-gene-by-smoking-interactions
#3
Pei-Chen Lee, Ismaïl Ahmed, Marie-Anne Loriot, Claire Mulot, Kimberly C Paul, Jeff M Bronstein, Beate Ritz, Alexis Elbaz
OBJECTIVE: To investigate whether cigarette smoking interacts with genes involved in individual susceptibility to xenobiotics for the risk of Parkinson disease (PD). METHODS: Two French population-based case-control studies (513 patients, 1,147 controls) were included as a discovery sample to examine gene-smoking interactions based on 3,179 single nucleotide polymorphisms (SNPs) in 289 genes involved in individual susceptibility to xenobiotics. SNP-by-cigarette smoking interactions were tested in the discovery sample through an empirical Bayes (EB) approach...
January 19, 2018: Neurology
https://www.readbyqxmd.com/read/29351473/sympathetically-mediated-cardiac-responses-to-isolated-muscle-metaboreflex-activation-following-exercise-are-modulated-by-body-position-in-humans
#4
André L Teixeira, Mauricio Daher, Mayara Souza, Plinio Santos Ramos, James P Fisher, Lauro C Vianna
Isolated muscle metaboreflex activation with post-handgrip exercise ischemia (PEI) increases sympathetic nerve activity and partially maintains the exercise-induced increase in blood pressure, but a smaller heart rate (HR) response occurs. The cardiopulmonary baroreceptors, mechanically sensitive receptors that respond to changes in central blood volume and pressure, are strongly associated with changes in body position and upon activation elicit reflex sympathoinhibition. Here, we tested the hypothesis that postural changes modulate the sympathetically-mediated cardiac response to PEI in humans...
December 15, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351468/gabaergic-contribution-to-the-muscle-mechanoreflex-mediated-heart-rate-responses-at-the-onset-of-exercise-in-humans
#5
André L Teixeira, Plinio Santos Ramos, Milena Samora, Jeann L Sabino-Carvalho, Djalma Rabelo Ricardo, Eduardo Colombari, Lauro C Vianna
Previous studies indicated that central GABAergic mechanisms are involved in the heart rate (HR) responses at the onset of exercise. Based on previous research that showed similar increases in HR during passive and active cycling, we reasoned that the GABAergic mechanisms involved in the HR responses at the exercise onset is primarily mediated by muscle mechanoreceptors afferents. Therefore, in this study we sought to determine if central GABA mechanisms are involved in the muscle mechanoreflex-mediated HR responses at the onset of exercise in humans...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29350622/beyond-hrv-attractor-reconstruction-using-the-entire-cardiovascular-waveform-data-for-novel-feature-extraction
#6
Philip J Aston, Mark I Christie, Ying H Huang, Manasi Nandi
Advances in monitoring technology allow blood pressure waveforms to be collected at sampling frequencies of 250-1000Hz for long time periods. However, much of the raw data are under analysed. Heart rate variability (HRV) methods, in which beat-to-beat interval lengths are extracted and analysed, have been extensively studied, However, this approach discards the majority of the raw data. OBJECTIVE: Our aim is to detect changes in the shape of the waveform in long streams of blood pressure data...
January 19, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29350428/meta-analysis-of-fish-early-life-stage-tests-association-of-toxic-ratios-and-acute-to-chronic-ratios-with-modes-of-action
#7
REVIEW
Stefan Scholz, Rene Schreiber, James Armitage, Philipp Mayer, Beate I Escher, Annegret Lidzba, Marc Léonard, Rolf Altenburger
Fish early life stage (FELS) tests (OECD test guideline 210) are widely conducted to estimate chronic fish toxicity. In these tests, fish are exposed from the embryonic to the juvenile life stage. In order to analyse whether certain modes of action are related to high toxic ratios (TR, i.e., ratios between experimental effect and baseline toxicity) and/or acute-to-chronic ratios (ACR) in the FELS test effect concentrations for 183 compounds were extracted from the US EPA ecotoxicity database. Analysis of effect concentration of narcotic compounds indicated that baseline toxicity could be observed in the FELS test at similar concentrations as in acute fish toxicity test...
January 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29350321/sliding-to-predict-vision-based-beating-heart-motion-estimation-by-modeling-temporal-interactions
#8
Angelica I Aviles-Rivero, Samar M Alsaleh, Alicia Casals
PURPOSE: Technical advancements have been part of modern medical solutions as they promote better surgical alternatives that serve to the benefit of patients. Particularly with cardiovascular surgeries, robotic surgical systems enable surgeons to perform delicate procedures on a beating heart, avoiding the complications of cardiac arrest. This advantage comes with the price of having to deal with a dynamic target which presents technical challenges for the surgical system. In this work, we propose a solution for cardiac motion estimation...
January 19, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29350189/detection-of-thoracic-vascular-structures-by-electrical-impedance-tomography-a-systematic-assessment-of-prominence-peak-analysis-of-impedance-changes
#9
Karin Henriette Wodack, Sarah Buehler, Sarah A Nishimoto, Michael F Graessler, Christoph R Behem, Andreas Daniel Waldmann, Beat Mueller, Stephan H Böhm, Eugenijus Kaniusas, Florian Thürk, Alexander Maerz, Constantin J C Trepte, Daniel A Reuter
Electrical impedance tomography (EIT) is a noninvasive and radiation free bedside monitoring technology, primarily used to monitor lung function. First experimental data shows that the descending aorta can be detected at different thoracic heights and might allow the assessment of central hemodynamics, i.e. stroke volume and pulse transit time. Approach: First, the feasibility of localizing small non-conductive objects within a saline phantom model was evaluated. Second, this result was utilized for the detection of the aorta by EIT in ten anesthetized pigs in with comparison to thoracic computer tomography (CT)...
January 19, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29348436/high-throughput-analysis-using-non-depletive-spme-challenges-and-applications-to-the-determination-of-free-and-total-concentrations-in-small-sample-volumes
#10
Ezel Boyacı, Barbara Bojko, Nathaly Reyes-Garcés, Justen J Poole, Germán Augusto Gómez-Ríos, Alexandre Teixeira, Beate Nicol, Janusz Pawliszyn
In vitro high-throughput non-depletive quantitation of chemicals in biofluids is of growing interest in many areas. Some of the challenges facing researchers include the limited volume of biofluids, rapid and high-throughput sampling requirements, and the lack of reliable methods. Coupled to the above, growing interest in the monitoring of kinetics and dynamics of miniaturized biosystems has spurred the demand for development of novel and revolutionary methodologies for analysis of biofluids. The applicability of solid-phase microextraction (SPME) is investigated as a potential technology to fulfill the aforementioned requirements...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348388/disseminated-histoplasmosis-in-an-indonesian-hiv-positive-patient-a-case-diagnosed-by-fine-needle-aspiration-cytology
#11
Nungki Anggorowati, Rita C Sulistyaningsih, Ahmad Ghozali, Yanri W Subronto
A 30-year-old Javanese-Indonesian man was admitted with complaints of 3 months persistent fever, weight loss, and fatigue. He had never known his past history of unprotected HIV until the admission. His only risk factor is unsafe sex. The patient seemed well nourished. Physical examination revealed blood pressure 100/60 mmHg, pulse 100 beats per minute, respiratory rate 20 times per minute, and temperature 38.8°C. Multiple cervical and inguinal lymphadenopathies were also found. Electrocardiogram showed anterolateral ischemic finding, whereas chest X-ray were normal...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29348021/learning-from-patients-with-ultrarare-conditions-cholesterol-hoof-beats
#12
EDITORIAL
Robert A Hegele
No abstract text is available yet for this article.
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29347779/effective-viscosity-of-a-suspension-of-flagellar-beating-microswimmers-three-dimensional-modeling
#13
Levan Jibuti, Walter Zimmermann, Salima Rafaï, Philippe Peyla
Micro-organisms usually can swim in their liquid environment by flagellar or ciliary beating. In this numerical work, we analyze the influence of flagellar beating on the orbits of a swimming cell in a shear flow. We also calculate the effect of the flagellar beating on the rheology of a dilute suspension of microswimmers. A three-dimensional model is proposed for Chlamydomonas Reinhardtii swimming with a breaststroke-like beating of two anterior flagella modeled by two counter-rotating fore beads. The active swimmer model reveals unusual angular orbits in a linear shear flow...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347559/how-anisotropy-beats-fractality-in-two-dimensional-on-lattice-diffusion-limited-aggregation-growth
#14
Denis S Grebenkov, Dmitry Beliaev
We study the fractal structure of diffusion-limited aggregation (DLA) clusters on a square lattice by extensive numerical simulations (with clusters having up to 10^{8} particles). We observe that DLA clusters undergo strongly anisotropic growth, with the maximal growth rate along the axes. The naive scaling limit of a DLA cluster by its diameter is thus deterministic and one-dimensional. At the same time, on all scales from the particle size to the size of the entire cluster it has a nontrivial box-counting fractal dimension which corresponds to the overall growth rate, which, in turn, is smaller than the growth rate along the axes...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347013/correlations-in-magnitude-series-to-assess-nonlinearities-application-to-multifractal-models-and-heartbeat-fluctuations
#15
Pedro A Bernaola-Galván, Manuel Gómez-Extremera, A Ramón Romance, Pedro Carpena
The correlation properties of the magnitude of a time series are associated with nonlinear and multifractal properties and have been applied in a great variety of fields. Here we have obtained the analytical expression of the autocorrelation of the magnitude series (C_{|x|}) of a linear Gaussian noise as a function of its autocorrelation (C_{x}). For both, models and natural signals, the deviation of C_{|x|} from its expectation in linear Gaussian noises can be used as an index of nonlinearity that can be applied to relatively short records and does not require the presence of scaling in the time series under study...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346192/image-quality-overall-evaluability-and-effective-radiation-dose-of-coronary-computed-tomography-angiography-with-prospective-electrocardiographic-triggering-plus-intracycle-motion-correction-algorithm-in-patients-with-a-heart-rate-over-65-beats-per-minute
#16
Gianluca Pontone, Giuseppe Muscogiuri, Andrea Baggiano, Daniele Andreini, Andrea I Guaricci, Marco Guglielmo, Fabio Fazzari, Saima Mushtaq, Edoardo Conte, Andrea Annoni, Alberto Formenti, Elisabetta Mancini, Massimo Verdecchia, Laura Fusini, Lorenzo Bonfanti, Elisa Consiglio, Mark G Rabbat, Antonio L Bartorelli, Mauro Pepi
PURPOSE: Recently, a new intracycle motion correction algorithm (MCA) was introduced to reduce motion artifacts from heart rate (HR) in coronary computed tomography angiography (cCTA). The aim of the study was to evaluate the image quality, overall evaluability, and effective radiation dose (ED) of cCTA with prospective electrocardiographic (ECG) triggering plus MCA as compared with standard protocol with retrospective ECG triggering in patients with HR≥65 bpm. MATERIALS AND METHODS: One hundred consecutive patients (67±10 y) scheduled for cCTA with 65<HR<80 bpm were retrospectively analyzed...
January 16, 2018: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29346017/the-role-of-posterior-parietal-cortex-in-beat-based-timing-perception-a-continuous-theta-burst-stimulation-study
#17
Jessica M Ross, John R Iversen, Ramesh Balasubramaniam
There is a growing interest in how the brain's motor systems contribute to the perception of musical rhythms. The Action Simulation for Auditory Prediction hypothesis proposes that the dorsal auditory stream is involved in bidirectional interchange between auditory perception and beat-based prediction in motor planning structures via parietal cortex [Patel, A. D., & Iversen, J. R. The evolutionary neuroscience of musical beat perception: The Action Simulation for Auditory Prediction (ASAP) hypothesis. Frontiers in Systems Neuroscience, 8, 57, 2014]...
January 18, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29345960/pacing-strategies-by-age-in-marathon-cross-country-skiing
#18
Pantelis Theodoros Nikolaidis, Beat Knechtle
OBJECTIVES: Pacing strategies have mainly been investigated for runners, but little is known for cross-country skiers. The aim of the present study was to investigate whether differences in pacing strategies do exist between younger and older cross-country skiers competing in the 42km 'Engadin Ski Marathon'. METHODS: Pacing was studied in 105,565 cross-country skiers (classified in 5-year age groups) competing between 1998 and 2016 in this race by examining changes of mean section velocity in 10km (Change A, i...
January 18, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29344439/regiochemical-control-in-triptycene-formation-an-exercise-in-subtle-balancing-multiple-factors
#19
Jan-Hendrik Lamm, Yury V Vishnevskiy, Eric Ziemann, Beate Neumann, Hans-Georg Stammler, Norbert W Mitzel
Reactions between 1,8-dichloroanthracenes with substituents in position 10 and ortho-chloroaryne afford mixtures of 1,8,13- (syn) and 1,8,16-trichlorotriptycenes (anti). The syn/anti ratio is dependent on these substituents. Electropositive substituents like SiMe3 and GeMe3 lead to preferred formation of the syn-isomer, whereas CMe3 groups exclusively afford the anti-isomer. Different quantum chemical calculations including location of transition states give conflicting results, but indicate the importance of dispersion forces for an at least qualitative prediction of results...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29343811/a-procession-of-metabolic-alterations-accompanying-muscle-senescence-in-manduca-sexta
#20
Bernard W M Wone, Jason M Kinchen, Elana R Kaup, Beate Wone
Biological aging profoundly impairs muscle function, performance, and metabolism. Because the progression of metabolic alterations associated with aging muscle has not been chronicled, we tracked the metabolic profiles of flight muscle from middle to advanced age in Manduca sexta to identify key molecules during the progression of muscle aging, as well as to evaluate the utility of the M. sexta system for molecular dissection of muscle aging. We identified a number of differences between Diel Time, Sexes, and Muscle Ages, including changes in metabolites related to energetics, extracellular matrix turnover, and glutathione metabolism...
January 17, 2018: Scientific Reports
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