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https://www.readbyqxmd.com/read/27876193/effect-of-adenovirus-mediated-tgf-%C3%AE-1-gene-transfer-on-the-function-of-rabbit-articular-chondrocytes
#1
Yuan Tang, Jun Xiao, Yeyang Wang, Ming Li, Zhanjun Shi
BACKGROUND: Articular chondrocytes are important in maintaining normal cartilage tissue and preventing articular degeneration. Exogenous genes have previously been transduced into articular cells using adenoviral vectors to contribute to the maintenance of cell function. This study aimed to transfer the transforming growth factor-β1 gene (TGF-β1) into rabbit articular chondrocytes by adenovirus infection to elucidate its effects on cell function. METHODS: Rabbit chondrocytes were isolated and cultured both as monolayers and three-dimensional culture systems...
November 18, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27868006/circulating-fibrocytes-serve-as-a-marker-for-clinical-diagnosis
#2
COMMENT
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27863082/allogeneic-platelet-rich-plasma-affects-monocyte-differentiation-to-dendritic-cells-causing-an-anti-inflammatory-microenvironment-putatively-fostering-the-wound-healing
#3
Andrea Papait, Ranieri Cancedda, Maddalena Mastrogiacomo, Alessandro Poggi
Autologous platelet rich plasma (PRP) is clinically used to induce repair of different tissues through the release of bioactive molecules. In some patients, the production of an efficient autologous PRP is unfeasible due to their compromised health. We developed an allogeneic PRP mismatched for AB0 and Rh antigens. To broadcast its clinical applications avoiding side effects the outcome of allogeneic PRP on immune response should be defined. Thus, we investigated whether PRP affected the differentiation of peripheral blood monocytes to dendritic cells upon stimulation with granulocyte monocyte colony stimulating factor and interleukin-4...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27809916/immunological-profiling-of-patients-with-ulcerative-colitis-leads-to-identification-of-two-inflammatory-conditions-and-cd1a-as-a-disease-marker
#4
M Föhlinger, P Palamides, U Mansmann, F Beigel, M Siebeck, R Gropp
BACKGROUND: Conventional approaches to understand mechanisms underlying the development of pathological manifestations in ulcerative colitis (UC) mostly rely on identification of certain cell types and cytokines followed by verification of their roles in vitro and in vivo. In light of the highly dynamic processes in UC, requiring the cross talk of immune cells, epithelial-, endothelial-, muscle cells and fibrocytes, this approach might neglect temporal and spatial connectivity of individually differing inflammatory responses...
November 3, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27773739/basic-fibroblast-growth-factor-induces-angiogenic-properties-of-fibrocytes-to-stimulate-vascular-formation-during-wound-healing
#5
Miho Nakamichi, Yuri Akishima-Fukasawa, Chie Fujisawa, Tetsuo Mikami, Kiyoshi Onishi, Yoshikiyo Akasaka
The precise role of fibrocytes in angiogenesis in wounds remains unclear. We therefore demonstrated the specific changes in fibrocyte accumulation for angiogesis in basic fibroblast growth factor (bFGF)-treated wounds. bFGF-treated wounds exhibited marked formation of arterioles and inhibition of podoplanin(+) lymph vessels that were lacking in vascular endothelial growth factor-A-treated wounds. Real-time PCR in bFGF-treated wounds manifested enhanced expression of CD34, CD31, and bFGF mRNA and reduced expression of podoplanin and collagen type I, III, and IV mRNA...
October 20, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27768856/elevated-serum-tetrac-in-graves-disease-potential-pathogenic-role-in-thyroid-associated-ophthalmopathy
#6
Roshini Fernando, Ekaterina Placzek, Edmund A Reese, Andrew T Placzek, Samantha Schwartz, Aaron Trierweiler, Leslie M Niziol, Stephen Atkins, Thomas S Scanlan, Terry J Smith
CONTEXT: The sources and biological impact of 3,3',5,5' tetraiodothyroacetic acid (TA4) are uncertain. CD34(+) fibrocytes express several proteins involved in the production of thyroid hormones. They infiltrate the orbit in Graves' disease (GD), an autoimmune process known as thyroid-associated ophthalmopathy. It appears that the thyrotropin receptor (TSHR) plays an important role in the pathogenesis of TAO. OBJECTIVE: To quantify levels of TA4 in healthy subjects and those with Graves' disease...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27768854/gastric-type-h-k-atpase-in-mouse-vestibular-end-organs
#7
Masaya Takumida, Hiroshi Takumida, Matti Anniko
CONCLUSION: Gastric type H(+),K(+)-ATPase in the vestibular end organs may be of importance for K(+) circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac. OBJECTIVE: To analyze the expression of gastric-type H(+),K(+)-ATPase in normal mouse vestibular end organs. METHODS: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H(+),K(+)-ATPase α and β in the vestibular end organs, viz...
October 21, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27762645/morphological-features-of-fascia-lata-in-relation-to-fascia-diseases
#8
Sylwia Szotek, Joanna Dawidowicz, Brian Eyden, Natalia Matysiak, Aleksander Czogalla, Grzegorz Dudzik, Anna Leśniewicz, Krzysztof Maksymowicz
Fascia lata is an important element of the fascial system, which forms the continuum of connective tissue throughout the body. This deep fascia envelops the entire thigh and hip area and its main function is to transmit mechanical forces generated by the musculoskeletal system of the lower extremities. Fascia lata is also known as a useful and easily harvested graft material. Despite its crucial role in lower extremity biomechanics and wide-ranging applications in plastic and reconstructive surgery, both the structure of fascia lata and particularly the cells populating this tissue are relatively unexplored and therefore poorly understood...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27757576/immunohistochemical-detection-of-intrathrombotic-fibrocytes-and-its-application-to-thrombus-age-estimation-in-murine-deep-vein-thrombosis-model
#9
Mizuho Nosaka, Yuko Ishida, Akihiko Kimura, Takashi Kawaguchi, Hiroki Yamamoto, Yumi Kuninaka, Toshikazu Kondo
Deep vein thrombi are dissolved after fibrosis process along with an increase of thrombus age. Fibrocytes are circulating bone marrow-derived cells with mesenchymal features that potentially have a unique and critical function in fibrosis. In this study, a double-color immunofluorescence analysis was carried out by using anti-CD45 and anti-collagen type I antibodies to examine the time-dependent appearance of fibrocytes in the murine model of stasis-induced deep vein thrombosis. The thrombus ages were 1, 3, 5, 7, 10, 14, and 21 days...
October 18, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27755517/progenitor-cells-in-sarcoidosis
#10
Tadeusz Płusa
Sarcoidosis is a systemic disease of unknown initiating factor. In the pathogenesis of the disease it emphasizes the importance of genetic factors, specificity of inflammation and toll-like receptors. No less important cell in the development of lesions is fibrocyte, which creates the final image of the disease in the form of fibrosis of the lung parenchyma. Data from experimental and clinical studies indicate that the progenitor cell can turn into fibrocyte. This indicates the possibility of controlling the process, which is already implemented in practice in Lung Institute in Pittsburgh, USA...
September 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27750208/cd45-expression-in-mitral-valve-endothelial-cells-after-myocardial-infarction
#11
Joyce Bischoff, Guillem Casanovas, Jill Wylie-Sears, Dae-Hee Kim, Philipp Bartko, J Guerrero, Jacob Dal-Bianco, Jonathan Beaudoin, Michael Garcia, Suzanne Sullivan, Margo Seybolt, Brittan Morris, Joshua Keegan, Whitney Irvin, Elena Aikawa, Robert Levine
RATIONALE: Ischemic mitral regurgitation (IMR), a complication after myocardial infarction (MI), induces adaptive mitral valve (MV) responses that may be initially beneficial, but eventually lead to leaflet fibrosis and MV dysfunction. We sought to examine the MV endothelial response and its potential contribution to IMR. OBJECTIVE: Endothelial, interstitial and hematopoietic cells in MVs from post-MI sheep were quantified. MV endothelial CD45, found post-MI, was analyzed in vitro...
October 6, 2016: Circulation Research
https://www.readbyqxmd.com/read/27709630/myeloid-derived-suppressor-cell-like-fibrocytes-are-increased-and-associated-with-preserved-lung-function-in-chronic-obstructive-pulmonary-disease
#12
A K A Wright, C Newby, R A Hartley, V Mistry, S Gupta, R Berair, K M Roach, R Saunders, T Thornton, M Shelley, K Edwards, B Barker, C E Brightling
BACKGROUND: The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS: Utilizing flow cytometry to identify circulating, collagen type 1(+) cells, we found two populations: (i) CD45(+) CD34(+) (fibrocytes) and (ii) CD45(+) CD34(-) [myeloid-derived suppressor cell (MDSC)-like fibrocytes] cells in stable COPD (n = 41) and control (n = 29) subjects...
October 6, 2016: Allergy
https://www.readbyqxmd.com/read/27698940/blocking-the-4-1bb-pathway-ameliorates-crystalline-silica-induced-lung-inflammation-and-fibrosis-in-mice
#13
Chao Li, Sitong Du, Yiping Lu, Xiaowei Lu, Fangwei Liu, Ying Chen, Dong Weng, Jie Chen
Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of crystalline silica-induced pulmonary fibrosis remain elusive. Herein, we find that 4-1BB is induced in response to crystalline silica injury in lungs and that it is highly expressed during development of experimental silicosis...
2016: Theranostics
https://www.readbyqxmd.com/read/27661853/fibrocytes-and-fibrovascular-membrane-formation-in-proliferative-diabetic-retinopathy
#14
Kazunori Tamaki, Ayumi Usui-Ouchi, Akira Murakami, Nobuyuki Ebihara
Purpose: The purpose of this study was to investigate whether fibrocytes participate in formation of the fibrovascular membrane (FVM) in patients with proliferative diabetic retinopathy (PDR). Methods: Vitreous fluid and FVM samples were obtained during vitrectomy in patients with PDR. Samples from patients with macular hole or epiretinal membrane were used as controls. Vitreous fluid and FVM samples were subjected to immunohistochemical analysis. In addition, cells isolated from the vitreous fluid of PDR and control patients were cultured in serum-free medium...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27632409/progressive-myoclonus-epilepsy-in-congenital-generalized-lipodystrophy-type-2-report-of-3-cases-and-literature-review
#15
Roberta Opri, Gian Maria Fabrizi, Gaetano Cantalupo, Moreno Ferrarini, Alessandro Simonati, Bernardo Dalla Bernardina, Francesca Darra
PURPOSE: A small case series with a neurodegenerative disorder involving central nervous system and related to Seipin mutations was recently reported. Herein we describe clinical and EEG features of three patients presenting with Progressive Myoclonus Epilepsy (PME) and Congenital Generalized Lipodystrophy type 2 (CGL2) related to novel Seipin mutations. METHODS: The EEG-clinical picture was evaluated at epilepsy onset and in the follow-up period. The molecular analysis of BSCL2, Laforin and Malin genes was performed to patients and/or their parents by Denaturing High Performance Liquid Chromatography and automated nucleotide sequencing...
September 5, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27631497/cd40-expression-in-fibrocytes-is-induced-by-tsh-potential-synergistic-immune-activation
#16
Tünde Mester, Nupur Raychaudhuri, Erin F Gillespie, Hong Chen, Terry J Smith, Raymond S Douglas
CONTEXT: Fibrocytes appear to participate in inflammation and tissue remodeling in patients with thyroid-associated ophthalmopathy (TAO). These patients have increased frequencies of circulating TSH receptor (TSHR)- and CD40-positive fibrocytes, suggesting TSHR and CD40 may play roles in proinflammatory cytokine production, which ultimately leads to orbital inflammation and tissue remodeling. OBJECTIVE: To investigate the potential interactions between the TSHR and CD40 signaling pathways and their roles in IL-6 and TNF-α production...
2016: PloS One
https://www.readbyqxmd.com/read/27623697/ultrastructural-ssrdna-sequencing-of-myxobolus-prochilodus-and-myxobolus-porofilus-and-details-of-the-interaction-with-the-host-prochilodus-lineatus
#17
Suellen A Zatti, Sarah Arana, Antônio A M Maia, Edson A Adriano
Myxobolus prochilodus and Myxobolus porofilus are parasites of Prochilodus lineatus, an economically important South American fish found in La Plata and Paraiba do Sul river basins. This study focusing on parasite-host interaction provides an ultrastructural and phylogenetic analysis, the latter based on ssrDNA sequencing of these parasites respectively infecting the gill filaments and fins of P. lineatus taken from the Mogi Guaçu River, São Paulo, Brazil. A total of 13 adult specimens were examined in this study...
September 14, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27612658/thyrotropin-and-cd40l-stimulate-interleukin-12-expression-in-fibrocytes-implications-for-pathogenesis-of-thyroid-associated-ophthalmopathy
#18
Tong Wu, Tünde Mester, Shivani Gupta, Fengyuan Sun, Terry J Smith, Raymond S Douglas
BACKGROUND: Increased numbers of bone marrow-derived progenitor cells, known as fibrocytes, populate the peripheral circulation, orbit, and thyroid of patients with Graves' disease (GD). These cells have been implicated in the development of thyroid-associated ophthalmopathy. They can differentiate into myofibroblasts or adipocytes, produce inflammatory cytokines, and remodel tissue. This study sought to determine whether thyrotropin (TSH) and CD40 ligand (CD40L), implicated in the pathogenesis of GD, induce interleukin-12 (IL-12) in human fibrocytes...
October 18, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27591095/the-characteristics-of-activated-portal-fibroblasts-myofibroblasts-in-liver-fibrosis
#19
Daniel Karin, Yukinori Koyama, David Brenner, Tatiana Kisseleva
Liver fibrosis results from chronic injury of hepatocytes and activation of Collagen Type I producing myofibroblasts that produce fibrous scar in liver fibrosis. Myofibroblasts are not present in the normal liver but rapidly appear early in experimental and clinical liver injury. The origin of the myofibroblast in liver fibrosis is still unresolved. The possibilities include activation of liver resident cells including portal fibroblasts, hepatic stellate cells, mesenchymal progenitor cells, and fibrocytes recruited from the bone marrow...
August 30, 2016: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27571432/recovery-of-endocochlear-potential-after-severe-damage-to-lateral-wall-fibrocytes-following-acute-cochlear-energy-failure
#20
Kyoko Kitao, Kunio Mizutari, Susumu Nakagawa, Tatsuo Matsunaga, Satoshi Fukuda, Masato Fujii
Reduction of endocochlear potential (EP) is one of the main causes of sensorineural hearing loss. In this study, we investigated changes in the EP using a mouse model of acute cochlear energy failure, which comprised severe cochlear lateral wall damage induced by the local administration of 3-nitropropionic acid to the inner ear. We also analyzed the correlation between EP changes and histological findings in the cochlear lateral wall. We detected the recovery of the EP and hearing function at lower frequencies after severe damage of the cochlear lateral wall fibrocytes at the corresponding region...
October 19, 2016: Neuroreport
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