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https://www.readbyqxmd.com/read/28651410/-application-of-tipping-point-analysis-to-address-missing-data-in-clinical-studies
#1
S J Zhang, Y Wang, W Li
To use a visualized method, tipping-point analysis to address missing data in clinical study and discuss related problems. All the possible outcomes caused by missing data were listed and the tipping points where P-values of hypothesis test changed at 0.05 significant level were found out, then the ratio of P<0.05 was calculated, reflecting the reliability of the study's result. Tipping-point analysis can be applied to both continuous and binary data to help find points where p-values are changed. The area of P<0...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651381/meta-barcoding-in-combination-with-palynological-inference-is-a-potent-diagnostic-marker-for-honey-floral-composition
#2
Rama Chandra Laha, Surajit De Mandal, Lalhmanghai Ralte, Laldinfeli Ralte, Nachimuthu Senthil Kumar, Guruswami Gurusubramanian, Ramalingam Satishkumar, Raja Mugasimangalam, Nagesh Aswathnarayana Kuravadi
Identification of floral samples present in honey is important in order to determine the medicinal value, enhance the production of honey as well as to conserve the honey bees. Traditional approaches for studying pollen samples are based on microscopic observation which is laborious, time intensive and requires specialized palynological knowledge. Present study compares two composite honey metagenome collected from 20 samples in Mizoram, Northeast India using three gene loci- rbcL, matK and ITS2 that was sequenced using a next-generation sequencing (NGS) platform (Illumina Miseq)...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28651376/comparison-of-sampling-strategies-for-tobacco-retailer-inspections-to-maximize-coverage-in-vulnerable-areas-and-minimize-cost
#3
Joseph G L Lee, Bonnie E Shook-Sa, J Michael Bowling, Kurt M Ribisl
Introduction: In the United States, tens of thousands of inspections of tobacco retailers are conducted each year. Various sampling choices can reduce travel costs, emphasize enforcement in areas with greater non-compliance, and allow for comparability between states and over time. We sought to develop a model sampling strategy for state tobacco retailer inspections. Methods: Using a 2014 list of 10,161 North Carolina tobacco retailers, we compared results from simple random sampling; stratified, clustered at the ZIP code sampling; and, stratified, clustered at the census tract sampling...
June 23, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28651339/formation-of-silica-aggregates-in-sorghum-root-endodermis-is-predetermined-by-cell-wall-architecture-and-development
#4
Milan Soukup, Michal Martinka, Dragana Bosnic, Mária Caplovicová, Rivka Elbaum, Alexander Lux
Background and Aims: Deposition of silica in plant cell walls improves their mechanical properties and helps plants to withstand various stress conditions. Its mechanism is still not understood and silica-cell wall interactions are elusive. The objective of this study was to investigate the effect of silica deposition on the development and structure of sorghum root endodermis and to identify the cell wall components involved in silicification. Methods: Sorghum bicolor seedlings were grown hydroponically with (Si+) or without (Si-) silicon supplementation...
June 22, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28651334/tsgsis-a-high-dimensional-grouped-variable-selection-approach-for-detection-of-whole-genome-snp-snp-interactions
#5
Yao-Hwei Fang, Jie-Huei Wang, Chao A Hsiung
Motivation: Identification of single nucleotide polymorphism (SNP) interactions is an important and challenging topic in genome-wide association studies (GWAS). Many approaches have been applied to detecting whole-genome interactions. However, these approaches to interaction analysis tend to miss causal interaction effects when the individual marginal effects are uncorrelated to trait, while their interaction effects are highly associated with the trait. Results: A grouped variable selection technique, called two-stage grouped sure independence screening (TS-GSIS), is developed to study interactions that may not have marginal effects...
June 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28651326/heterogeneity-in-cultivation-based-monitoring-of-airborne-bacterial-biodiversity-in-animal-farms
#6
Udo Jäckel, Elena Martin, Jenny Schäfer
Diversity analyses of bioaerosol samples from highly loaded workplaces as found in agricultural production or waste management help to improve the knowledge of exposure levels of workers. However, different used methods resulting in the detection of different bacterial species at the same work places. The present study obviously supports the deviation of received results using cultivation and further isolation approaches. Within the present study, the bacterial community at workplaces was estimated using the powerful tool of 16S rRNA gene sequence analyses after cultivation procedure...
June 23, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28651299/survival-estimates-after-stopping-sorafenib-in-patients-with-hepatocellular-carcinoma-next-score-development-and-validation
#7
Hye Won Lee, Hyun Soo Kim, Seung Up Kim, Do Young Kim, Beom Kyung Kim, Jun Yong Park, Sang Hoon Ahn, Mi Young Jeon, Ja Yoon Heo, Soo Young Park, Yu Rim Lee, Sun Kyung Jang, Su Hyun Lee, Se Young Jang, Won Young Tak, Kwang-Hyub Han
Background/Aims: Limited information is available regarding patient survival after sorafenib discontinuation in patients with hepatocellular carcinoma (HCC). Thus, we developed and validated a novel survival prediction model. Methods: Clinical data from 409 patients with HCC who stopped taking sorafenib between September 2008 and February 2015 were reviewed. Results: In the training cohort, four factors were independent negative predictors of survival (p<0...
June 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28651218/urban-water-metabolism-indicators-derived-from-a-water-mass-balance-bridging-the-gap-between-visions-and-performance-assessment-of-urban-water-resource-management
#8
M A Renouf, S Serrao-Neumann, S J Kenway, E A Morgan, D Low Choy
Improving resource management in urban areas has been enshrined in visions for achieving sustainable urban areas, but to date it has been difficult to quantify performance indicators to help identify more sustainable outcomes, especially for water resources. In this work, we advance quantitative indicators for what we refer to as the 'metabolic' features of urban water management: those related to resource efficiency (for water and also water-related energy and nutrients), supply internalisation, urban hydrological performance, sustainable extraction, and recognition of the diverse functions of water...
May 29, 2017: Water Research
https://www.readbyqxmd.com/read/28651175/challenges-in-gc-ms-analysis-case-studies-on-phenibut-and-ethylphenidate
#9
Hui Zhi Shirley Lee, Mei Ching Ong, Jong Lee Wendy Lim, Tiong Whei Angeline Yap
The challenges associated with drug analysis using GC-MS such as thermal degradation, cyclisation or unwanted side reactions causing potential erroneous identification have become evident in view of the high surge in new drugs available in the market. Two case studies illustrated how alternative methods or modifications to existing techniques can help to circumvent the limitations. In the first case study, phenibut which is a GABA analogue, cyclises to 4-phenyl-2-pyrrolidinone under thermal conditions. The identification of phenibut was achieved through derivatisation and identification of its TMS derivative...
June 9, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28651153/the-role-of-marijuana-use-disorder-in-predicting-emergency-department-and-inpatient-encounters-a-retrospective-cohort-study
#10
Cynthia I Campbell, Amber L Bahorik, Andrea H Kline-Simon, Derek D Satre
BACKGROUND: Marijuana use disorder (MUD) is the most common illegal drug use disorder and its prevalence is increasing. It is associated with psychiatric and medical problems, but little is known about its impact on emergency department (ED) and inpatient utilization rates. DESIGN: In a retrospective cohort design, we used electronic health record (EHR) data to identify patients with MUD (n=2752) and demographically matched patients without MUD (n=2752) in 2010...
June 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28651132/enhanced-acetone-butanol-ethanol-production-from-lignocellulosic-hydrolysates-by-using-starchy-slurry-as-supplement
#11
Ming Yang, Suvi Kuittinen, Jouko Vepsäläinen, Junhua Zhang, Ari Pappinen
This study aims to improve acetone-butanol-ethanol production from the hydrolysates of lignocellulosic material by supplementing starchy slurry as nutrients. In the fermentations of glucose, xylose and the hydrolysates of Salix schwerinii, the normal supplements such as buffer, minerals, and vitamins solutions were replaced with the barley starchy slurry. The ABE production was increased from 0.86 to 14.7g/L by supplementation of starchy slurry in the fermentation of xylose and the utilization of xylose increased from 29% to 81%...
June 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651120/the-relationship-between-emotion-regulation-strategies-and-job-search-behavior-among-fourth-year-university-students
#12
Ling Wang, Huihui Xu, Xue Zhang, Ping Fang
The job search process is a stressful experience. This study investigated the effect of emotion regulation strategies on job search behavior in combination with anxiety and job search self-efficacy among Chinese university fourth-year students (N = 816, mean age = 21.98, 31.5% male, 34.9% majored in science, 18.0% from "211 Project" universities). Results showed that cognitive reappraisal was positively related to job search behavior, while expressive suppression was negatively related to job search behavior...
June 23, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28651108/synchronous-characterization-of-carbohydrates-and-ginsenosides-yields-deeper-insights-into-the-processing-chemistry-of-ginseng
#13
Shan-Shan Zhou, Jun Xu, Ming Kong, Ka-Man Yip, Jin-Di Xu, Hong Shen, Zhong-Zhen Zhao, Song-Lin Li, Hu-Biao Chen
Carbohydrates and ginsenosides in ginseng are biologically interrelated. Their synchronous analysis is therefore essential in chemical research on ginseng to characterize its "holistic" quality. Here we investigated the processing chemistry of red ginseng (RG), a ginseng product processed by water-steaming, for which both carbohydrates and ginsenosides were qualitatively and quantitatively determined through multiple analytical techniques. Results revealed that the steam-processing not only qualitatively and quantitatively altered the ginsenosides but also affected the polymeric carbohydrates via changing their physiochemical parameters, i...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28651082/impact-of-humic-acid-on-the-degradation-of-levofloxacin-by-aqueous-permanganate-kinetics-and-mechanism
#14
Ke Xu, Weiwei Ben, Wencui Ling, Yu Zhang, Jiuhui Qu, Zhimin Qiang
Levofloxacin (LF) is a frequently detected fluoroquinolone in surface water, and permanganate (MnO4(-)) is a commonly used oxidant in drinking water treatment. This study investigated the impact of humic acid (HA) on LF degradation by aqueous MnO4(-) from both kinetic and mechanistic aspects. In the absence of HA, the second-order rate constant (k) of LF degradation by MnO4(-) was determined to be 3.9 M(-1) s(-1) at pH 7.5, which increased with decreasing pH. In the presence of HA, the pseudo-first-order rate constant (kobs) of LF degradation at pH 7...
June 14, 2017: Water Research
https://www.readbyqxmd.com/read/28651066/thalassemia-major-transfusion-and-chelation-or-transplantation
#15
REVIEW
Said Yousuf Mohamed
Thalassemia is the most common monogenic hematologic disease that affects millions in the world and kills thousands of patients every year. Without transfusion or transplantation, patients with thalassemia major are expected to die within months of diagnosis. However, long-term transfusion and chelation therapy is highly challenging for many developing countries where the disease is prevalent, representing a major and unsustainable health burden. Stem cell transplantation is the only cure for thalassemia. It has witnessed major developments that have made it less toxic, more successful, and feasible for a larger number of patients with diverse comorbidities and from a wider range of donors...
June 20, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28651060/mechanism-underlying-methyl-eugenol-attenuation-of-intestinal-ischemia-reperfusion-injury
#16
Hanan Saleh, Haidan M El-Shorbagy
Intestinal Ischemia/Reperfusion injury (I/R) is associated with a high risk of mortality in the clinical situation. Many factors are involved in I/R including reactive oxygen species (ROS), cytokine release and apoptosis. We aimed to determine whether a pure methyl eugenol (ME) given before intestinal ischemia, protects against intestinal I/R and the possible mechanism involved in this protection. Rat received ME (100 mg/kg) for 30 days then underwent intestinal I/R with 30 min ischemia and 60 min reperfusion...
June 26, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28651032/evidence-based-practice-guideline-persistent-pain-management-in-older-adults
#17
Paul Arnstein, Keela A Herr, Howard K Butcher
More individuals develop and endure constant or recurring pain in older adulthood. Although 40% of these individuals receive no treatment, many evidence-based treatments are available. Accurate assessment of pain, its impact on functioning, and preventing treatment-related harms lay the foundation of safe, effective pain control. Analgesic agents are often necessary, but require a delicate balance to prevent under-treatment, the unnecessary abandonment of therapy, or exposure to potentially serious adverse effects...
July 1, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28651026/binding-of-human-plasminogen-and-high-molecular-mass-kininogen-by-cell-surface-exposed-proteins-of-candida-parapsilosis
#18
Justyna Karkowska-Kuleta, Dorota Zajac, Grazyna Bras, Oliwia Bochenska, Maria Rapala-Kozik, Andrzej Kozik
Pathogenic microbes can recruit to their cell surface human proteins that are components of important proteolytic cascades involved in coagulation, fibrinolysis and innate immune response. Once located at the bacterial or fungal surface, such deployed proteins might be utilized by pathogens to facilitate invasion and dissemination within the host organism by interfering with functionality of these systems or by exploiting specific activity of the bound enzymes. Aim of the study presented here was to characterize this phenomenon in Candida parapsilosis (Ashford) Langeron et Talice - an important causative agent of systemic fungal infections (candidiases and candidemias) in humans...
June 24, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28651010/macrophages-but-not-neutrophils-are-critical-for-proliferation-of-burkholderia-cenocepacia-and-ensuing-host-damaging-inflammation
#19
Jennifer Mesureur, Joana R Feliciano, Nelly Wagner, Margarida C Gomes, Lili Zhang, Monica Blanco-Gonzalez, Michiel van der Vaart, David O'Callaghan, Annemarie H Meijer, Annette C Vergunst
Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute infection and septicemia are not known. Bcc bacteria are generally believed to have a predominant extracellular biofilm life style in infected CF lungs, similar to Pseudomonas aeruginosa, but this has been challenged by clinical observations which show Bcc bacteria predominantly in alveolar macrophages...
June 26, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28650990/identification-of-soil-p-fractions-that-are-associated-with-p-loss-from-surface-runoff-under-various-cropping-systems-and-fertilizer-rates-on-sloped-farmland
#20
Xinghua Li, Baona Wang, Tewu Yang, Duanwei Zhu, Zhongnan Nie, Junchi Xu
Soil phosphorus (P) fractions and runoff P concentration were measured to understand the fate of soil P entering surface runoff water during summer cropping season of different double cropping systems under two fertilizer regimes. The dominant form of runoff P was particulate P (PP). Runoff total P (TP) was higher at the vegetative growth stage and lower at the crop reproductive stage. TP and PP were derived mainly from soil Olsen-P, Al-P and Fe-P and amounts increased with sediment content in runoff water...
2017: PloS One
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