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https://www.readbyqxmd.com/read/29156852/risk-factors-for-recurrent-central-line-associated-bloodstream-infections-in-a-pediatric-intensive-care-unit
#1
Rana İşgüder, İlker Devrim, Gökhan Ceylan, Ahu Kara, Gamze Gülfidan, Hasan Ağın
Background/aim: It is recommended that a central venous catheter (CVC) be removed if central line-associated bloodstream infection (CLABSI) has been diagnosed. The objective of this retrospective study was to evaluate the risk factors for recurrent CLABSI in reinserted catheters in a pediatric intensive care unit. Materials and methods: Patients with recurrent and nonrecurrent CLABSI were compared in terms of the catheter exchange interval, the interval between negative blood culture and reinsertion of the CVC, and the pre-/reinsertion treatment duration...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156838/associations-between-dietary-folate-intake-and-risks-of-esophageal-gastric-and-pancreatic-cancers-an-overall-and-dose-response-meta-analysis
#2
Wen Liu, Heng Zhou, Yaoqi Zhu, Chaorong Tie
There are still some controversies on the association between dietary folate intake and the risk of upper gastrointestinal cancers including esophageal, gastric and pancreatic cancers. Hence, a comprehensive meta-analysis on all available literatures was performed to clarify the relationship between dietary folate intake and risks of upper gastrointestinal cancers. An electric search was performed up to December 12(th), 2016 within the PubMed, MEDLINE AND EMBASE databases. Ultimately, a total of 46 studies which evaluated the association between folate intake and risks of upper gastrointestinal cancers were included...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156744/changes-of-alpha-fetoprotein-levels-could-predict-recurrent-hepatocellular-carcinoma-survival-after-trans-arterial-chemoembolization
#3
Chao He, Xiaoyun Zhang, Chuan Li, Wei Peng, Tian-Fu Wen, Lv-Nan Yan, Jiayin Yang, Wusheng Lu
Background: There is paucity of information concerning whether AFP change is a predictor of prognosis for recurrent hepatocellular carcinoma (RHCC) patients after trans-arterial chemoembolization (TACE). Methods: A total of 177 RHCC patients who received TACE as first-line therapy were retrospectively analyzed. The patients were classified into three groups according to their pre-TACE and post-TACE AFP levels (group A: AFP decreased, group B: AFP consistent normal, and group C: AFP increased)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156727/bone-marrow-irf4-level-in-multiple-myeloma-an-indicator-of-peripheral-blood-th17-and-disease
#4
Hua Bai, Shuang Wu, Rong Wang, Ji Xu, Lijuan Chen
Interferon regulator factor 4 (IRF4) is characterized to be a member of interferon regulatory family, which is predominantly expressed in bone marrow plasma cells of patients with multiple myeloma (MM). Recent studies indicated IRF4 is critical for T-help cells (Th17) differentiation and interleukin-17 (IL-17) secretion. Here, a total of 58 MM patients were enrolled in this study, the proportions of Th17 cells and T regulatory (Treg) cells in peripheral blood mononuclear cells (PBMCs) were determined by flow cytometric analysis...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156724/lncrna-pvt1-and-its-splicing-variant-function-as-competing-endogenous-rna-to-regulate-clear-cell-renal-cell-carcinoma-progression
#5
Tao Yang, Hui Zhou, Peijun Liu, Libin Yan, Weimin Yao, Ke Chen, Jin Zeng, Heng Li, Junhui Hu, Hua Xu, Zhangqun Ye
Long non-coding RNAs (lncRNAs) exert critical regulatory roles in the development and progression of several cancers. Plasmacytoma variant translocation 1 (PVT1), an lncRNA, was shown to be upregulated in clear cell renal cell carcinoma (ccRCC) in our study, while Kaplan-Meier curve and Cox regression analysis showed that high expression of PVT1 was associated with poor overall survival (OS) and disease free survival (DFS) in ccRCC patients. In vitro experiments revealed that PVT1 promoted renal cancer cell proliferation, migration, and invasion, while in vivo studies confirmed its oncogenic roles in ccRCC...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156690/abnormal-amplitude-of-low-frequency-fluctuations-associated-with-rapid-eye-movement-in-chronic-primary-insomnia-patients
#6
Qian Ran, Jia Chen, Chuan Li, Li Wen, Faguo Yue, Tongsheng Shu, Jianxun Mi, Guangxian Wang, Lei Zhang, Dong Gao, Dong Zhang
Purpose: Chronic primary insomnia (CPI) is the most prevalent sleep disorder worldwide. CPI manifests as difficulties in sleep onset, maintaining sleep, prolonged sleep latency, and daytime impairment and is often accompanied by cognitive problems such as poor academic performance, poor attention, and decreased memory. The most popular explanation of insomnia is hyperarousal or increased activities of neurons. Rapid eye movement (REM) sleep detected by polysomnography (PSG) exhibits a positive relationship with brain homeostasis and can be helpful for optimally preparing an organism for emotional and social function...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156638/development-of-evidence-based-disease-education-literature-for-pakistani-rheumatoid-arthritis-patients
#7
Atta Abbas Naqvi, Mohamed Azmi Hassali, Muhammad Tariq Aftab, Syed Baqir Shyum Naqvi, Fatima Zehra, Rizwan Ahmad, Niyaz Ahmad
Rheumatoid arthritis affects 0.5% to 1% of the population globally and is one of the most common causes of disability. Patient education plays a key role in improving treatment outcomes. The purpose of this study was to discuss the process involved in designing an evidence-based disease education literature for rheumatoid arthritis patients of Pakistan in Urdu language with culturally relevant illustrations. A study was conducted to develop disease education literature using Delphi consensus, content validity, and patient feedback...
November 20, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/29156577/magnetic-flux-distribution-of-linear-machines-with-novel-three-dimensional-hybrid-magnet-arrays
#8
Nan Yao, Liang Yan, Tianyi Wang, Shaoping Wang
The objective of this paper is to propose a novel tubular linear machine with hybrid permanent magnet arrays and multiple movers, which could be employed for either actuation or sensing technology. The hybrid magnet array produces flux distribution on both sides of windings, and thus helps to increase the signal strength in the windings. The multiple movers are important for airspace technology, because they can improve the system's redundancy and reliability. The proposed design concept is presented, and the governing equations are obtained based on source free property and Maxwell equations...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156569/new-insights-into-the-microbiota-of-moth-pests
#9
REVIEW
Valeria Mereghetti, Bessem Chouaia, Matteo Montagna
In recent years, next generation sequencing (NGS) technologies have helped to improve our understanding of the bacterial communities associated with insects, shedding light on their wide taxonomic and functional diversity. To date, little is known about the microbiota of lepidopterans, which includes some of the most damaging agricultural and forest pests worldwide. Studying their microbiota could help us better understand their ecology and offer insights into developing new pest control strategies. In this paper, we review the literature pertaining to the microbiota of lepidopterans with a focus on pests, and highlight potential recurrent patterns regarding microbiota structure and composition...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156540/the-new-old-and-old-new-medical-model-four-decades-navigating-the-biomedical-and-psychosocial-understandings-of-health-and-illness
#10
REVIEW
Albert Farre, Tim Rapley
The importance of how disease and illness are conceptualised lies in the fact that such definition is paramount to understand the boundaries and scope of responsibility associated with medical work. In this paper, we aim to provide an overview of the interplay of these understandings in shaping the nature of medical work, philosophically, and in practice. We first discuss the emergence of the biopsychosocial model as an attempt to both challenge and broaden the traditional biomedical model. Then, we outline the main criticisms associated with the biopsychosocial model and note a range of contributions addressing the shortcomings of the model as initially formulated...
November 18, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29156535/hdacis-class-i-cancer-stem-cell-and-phytochemicals-cancer-therapy-and-prevention-implications
#11
REVIEW
Sahar Bayat, Mahmoud Shekari Khaniani, Jalal Choupani, Mohammad Reza Alivand, Sima Mansoori Derakhshan
Epigenetics is independent of the sequence events that physically affect the condensing of chromatin and genes expression. The unique epigenetic memories of various cells trigger exclusive gene expression profiling. According to different studies, the aberrant epigenetic signatures and impaired gene expression profiles are master occurrences in cancer cells in which oncogene and tumor suppressor genes are affected. Owing to the facts that epigenetic modifications are performed earlier than expression and are reversible, the epigenetic reprogramming of cancer cells could be applied potentially for their prevention, control, and therapy...
November 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156480/-frailty-prevalence-in-the-resident-population-of-germany-70%C3%A2-%C3%A2-79-years-of-age-a-population-based-approach
#12
Judith Fuchs, Markus Busch, Christa Scheidt-Nave
In all countries life expectancy is rising, and many older persons spend a longer period in good health. Nevertheless, frailty is present in older people and can be considered as a risk factor for limitations. The "German Health Interview and Examination Survey for Adults" (DEGS1) 2008 - 2011 comprised interviews, examinations and tests. Data on 1110 community-dwelling people aged 70 to 79 years participating in DEGS1 with full records on frailty were analysed. Physical frailty was defined as exhaustion (SF-36 item), low grip strength, slowness (Timed Up-and-Go test > 15 seconds or unable to perform) and low physical activity (no sports or exertion)...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29156467/-diagnosis-and-therapy-of-iris-lesions
#13
Joel M Mor, Konrad R Koch, Ludwig M Heindl
The most common iris lesions are iris nevi, iris melanomas and iris pigment epithelium cysts. However, there is an abundance of rare differential diagnoses that have to be considered, including other melanocytic and non-melanocytic lesions. Diagnostic tools include the slit lamp examination, gonioscopy, tonometry, transillumination, ultrasound biomicroscopy (UBM), optical coherence tomography, fluorescein angiography and standardized photography-assisted documentation. The timely identification of malignant lesions (i...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29156466/-retinal-artery-occlusions
#14
Gabriele E Lang, Stefan J Lang
Retinal artery occlusions are acute vascular diseases. Very often they are caused by an embolisation. Rarely a thrombosis is caused by an arteriitis. In the acute phase diagnosis in most of the cases can be made by ophthalmoscopy due to the whitish retinal edema and in central retinal artery occlusion the cherry red spot. Difficulties in making the diagnosis can occur in the chronic stage, especially after reperfusion of the retinal vessels, when the fundus colour returned to normal again. Several diagnostic procedures help to make the diagnosis...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29156465/-pseudophacic-additive-lenses
#15
Fritz H Hengerer, Ina Conrad-Hengerer
Implantation of artificial intraocular lenses (IOL) after cataract removal today represents the standard of care in the field of anterior segment surgery. In refractive lens exchange cases the natural lens is replaced by an IOL to correct different types of refractive situations. In the majority of the operations the refractive result is satisfying with only few deviations from target refraction.But daily practice reveals some outliers from the intended corrections with the need for further refractive enhancements, respectively...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29156436/impact-of-changes-in-labor-resources-and-transfers-of-land-use-rights-on-agricultural-non-point-source-pollution-in-jiangsu-province-china
#16
Hua Lu, Hualin Xie
This study systematically explores the likely mechanisms driving the effect of the transfer of agricultural land use rights (ALURs) on agricultural non-point source pollution (ANSP) in the context of changing agricultural labor resources. It quantitatively estimates the direction and degree of this influence from a microeconomic perspective using data from rural households. The results reveal that economies of scale caused by ALURs transfers contribute to reducing both the ANSP and marginal costs of inputs...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156430/chromium-tolerance-bioaccumulation-and-localization-in-plants-an-overview
#17
REVIEW
Vibha Sinha, Kannan Pakshirajan, Rakhi Chaturvedi
In the current industrial scenario, chromium (Cr) as a metal is of great importance, but poses a major threat to the environment. Phytoremediation provides an environmentally sustainable, ecofriendly, cost effective approach for environmental cleanup of Cr. This review presents the current status of phytoremediation research with particular emphasis on cleanup of Cr contaminated soil and water systems. It gives a detailed account of the work done by different authors on the Cr bioavailability, uptake pathway, toxicity and storage in plants following the phytoextraction mechanism...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156407/ultrasensitive-detection-of-prostate-specific-antigen-by-electrochemical-aptasensor-using-enzyme-free-recycling-amplification-via-target-induced-catalytic-hairpin-assembly
#18
Juncai Zhao, Zhanfang Ma
Based on the target-induced catalytic hairpin assembly and bimetallic catalyst, the enzyme-free recycling amplification strategy for sensitive detection of prostate specific antigen (PSA) has been designed. The aptamer and its complementary DNA (C-apt) are modified on the magnetic particles. The aptamer-PSA binding event can release the C-apt that triggers the catalytic assembly between hairpin capture DNA and hairpin help DNA. Then the catalytic hairpin assembly leads to cyclic reuse the C-apt and the generation of many opened hairpin capture DNA, which can associate with the prepared Au/Pt-polymethylene blue (PMB) probes to yield electrochemical signal...
November 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29156390/the-development-and-testing-of-the-nursing-student-perceptions-of-dishonesty-scale
#19
Emily L McClung, Joanne Kraenzle Schneider
BACKGROUND: Dishonesty in the classroom suggests dishonesty in practice. There is need to better understand nursing students' perceptions of dishonest behaviors in the classroom and clinical setting. There is currently no instrument to assess perceptions in the classroom and clinical setting. OBJECTIVE: The purpose of this study was to develop an instrument to assess nursing students' perceptions of academically dishonest behaviors in the classroom and clinical setting...
November 10, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29156374/genetic-profiling-and-surface-proteome-analysis-of-human-atrial-stromal-cells-and-rat-ventricular-epicardium-derived-cells-reveals-novel-insights-into-their-cardiogenic-potential
#20
Sebastian Temme, Daniela Friebe, Timo Schmidt, Gereon Poschmann, Julia Hesse, Bodo Steckel, Kai Stühler, Meik Kunz, Thomas Dandekar, Zhaoping Ding, Payam Akhyari, Artur Lichtenberg, Jürgen Schrader
Epicardium-derived cells (EPDC) and atrial stromal cells (ASC) display cardio-regenerative potential, but the molecular details are still unexplored. Signals which induce activation, migration and differentiation of these cells are largely unknown. Here we have isolated rat ventricular EPDC and rat/human ASC and performed genetic and proteomic profiling. EPDC and ASC expressed epicardial/mesenchymal markers (WT-1, Tbx18, CD73, CD90, CD44, CD105), cardiac markers (Gata4, Tbx5, troponin T) and also contained phosphocreatine...
November 7, 2017: Stem Cell Research
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