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https://www.readbyqxmd.com/read/28945033/-preparation-and-evaluation-of-gastric-adhesive-floating-pellets-for-bolo-leaf-phenols
#1
Ya-Li He, Ying Li, Dan-Dan Yang, Chun-Yan Zhu
Gastric adhesive-floating pellets for Bolo leaf phenols (BLP) were prepared by extrusion-spheronization method, with chitosan as skeleton bioadhesive material, and stearyl alcohol as help-bleaching agent to evaluate its in vitro adhesivity, floatability and in vivo retention situation, and investigate its in vitro release characteristics. The in vitro adhesivity and floatability were evaluated respectively by in vitro tissue retention method and visual observation method. The retention of pellets in rats was investigated by in vivo tissue retention method and in vivo imaging of small animals...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944980/failure-mode-and-effects-analysis-a-community-practice-perspective
#2
Bradley W Schuller, Angi Burns, Elizabeth A Ceilley, Alan King, Joan LeTourneau, Alexander Markovic, Lynda Sterkel, Brigid Taplin, Jennifer Wanner, Jeffrey M Albert
PURPOSE: To report our early experiences with failure mode and effects analysis (FMEA) in a community practice setting. METHODS: The FMEA facilitator received extensive training at the AAPM Summer School. Early efforts focused on department education and emphasized the need for process evaluation in the context of high profile radiation therapy accidents. A multidisciplinary team was assembled with representation from each of the major department disciplines. Stereotactic radiosurgery (SRS) was identified as the most appropriate treatment technique for the first FMEA evaluation, as it is largely self-contained and has the potential to produce high impact failure modes...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944938/-reverse-j-shaped-skin-flap-and-cranial-bone-groove-for-shunt-hardware-a-new-technique-in-patients-with-fragile-skin
#3
Murteza Cakir
INTRODUCTION: Shunt systems are not perfect devices and can cause severe complications. Complications may originate from problems related to the valve, the patient, or the surgery and more common in neonates, infants, especially preterm by reason of the special characteristics these patients owned. We therefore have succesfully developed useful and viable surgical technique in order to provide helpful aspects to surgical issues mentioned above. TECHNIQUE: This technique includes \"reverse J\" shaped skin incision with nonintersecting the shun's hardware and distal catheter and to be reduced the wound problems to the minimum rates by opening \"bone groove\"...
July 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944932/new-treatment-for-non-hodgkin-b-cell-lymphomas-with-a-special-focus-on-the-impact-of-junctional-adhesion-molecules
#4
Beat Albert Imhof, Thomas Matthes
Current therapeutic modalities used for B-cell lymphoma include chemotherapy, immunotherapy, and radiation therapy. Chemotherapy together with anti-CD20 monoclonal antibodies forms the cornerstone of therapy and has a curative, as well as a palliative, role in this disease. New treatment modalities targeting specific molecules on the surface of lymphoma cells or intracellular pathways regulating apoptosis, proliferation and cell division are intensively investigated. One such target is JAM-C, a molecule implicated in cell adhesion and in B cell migration and whose inhibition blocks B cells from reaching their supportive microenvironments in lymphoid organs...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944920/periodic-acid%C3%A2-schiff-staining-method-for-function-detection-of-liver-cells-is-affected-by-2-horse-serum-in-induction-medium
#5
Hui Hui, Wenjun Ma, Jiejie Cui, Mengjia Gong, Yi Wang, Yuanyuan Zhang, Tongchuan He, Yang Bi, Yun He
Developing a thorough understanding of experimental methods of hepatic differentiation in hepatic progenitor cells (HPCs) should expand the knowledge of hepatocyte induction in vitro and may help to develop cell transplantation therapies for the clinical usage of HPCs in liver diseases. A previous induction method effectively induced differentiation and metabolic abilities in HPCs. Periodic acid‑Schiff (PAS) staining is used to identify glycogen synthesis and hepatocyte function; however, this method failed to detect induced hepatocytes...
September 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944887/microrna%C3%A2-212-inhibits-colorectal-cancer-cell-viability-and-invasion-by-directly-targeting-pik3r3
#6
Jian Zhang, Yongkang Zhang, Xiaoyun Li, Hongbo Wang, Quan Li, Xiaofeng Liao
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer‑associated mortalities worldwide. Emerging evidence has shown that abnormal microRNA (miRNA) expression contributes to CRC carcinogenesis and progression by inhibiting the expression of their target genes. Therefore, investigating the expression patterns and roles of miRNAs specifically involved in CRC formation, and progression would help expand our knowledge on CRC and provide novel therapeutic targets for CRC treatment...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944830/application-of-the-amniotic-fluid-metabolome-to-the-study-of-fetal-malformations-using-down-syndrome-as-a-specific-model
#7
Jun Huang, Jinhua Mo, Guili Zhao, Qiyin Lin, Guanhui Wei, Weinan Deng, Dunjin Chen, Bolan Yu
Although monitoring and diagnosis of fetal diseases in utero remains a challenge, metabolomics may provide an additional tool to study the etiology and pathophysiology of fetal diseases at a functional level. In order to explore specific markers of fetal disease, metabolites were analyzed in two separate sets of experiments using amniotic fluid from fetuses with Down syndrome (DS) as a model. Both sets included 10‑15 pairs of controls and cases, and amniotic fluid samples were processed separately; metabolomic fingerprinting was then conducted using UPLC‑MS...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944798/transcriptomic-analysis-of-bama-pig-s-liver-in-various-nutritional-states-reveals-a-metabolic-difference-of-fatty-acids
#8
Yixing Li, Yi Chu, Lin Yu, Huifang Kang, Lei Zhou
Both fasting and treatment with a high-fat diet (HFD) can dramatically change fat metabolism in the liver and, thus, are commonly used methods to investigate hepatic fat metabolism and related diseases. Here, the gene expression profiles of pig liver under both conditions were investigated and changes in hepatic triacylglycerol (TG) levels under different diet conditions were determined. In this study, both fasting and HFD conditions significantly increased hepatic TG levels and serum levels of cholesterol, TG, high-density lipoprotein, low-density lipoprotein, and apolipoprotein B...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944762/a-cell-laden-hybrid-fiber-hydrogel-composite-for-ligament-regeneration-with-improved-cell-delivery-and-infiltration
#9
Jeong Hwa Kim, Yeong-Jin Choi, Hee-Gyeong Yi, Joon Ho Wang, Dong-Woo Cho, Young Hun Jeong
Ligament, a fibrous connective tissue between bones, is a unique tissue in human anatomy because it has complex viscoelastic properties and is very tough. Moreover, it is an important tissue for regeneration because frequent injuries occur, but there are limited types of substitutes that can be used as a tissue replacement. In this study, we present a stem cell-laden fiber/hydrogel composite structure with a layered fibrous structure, which can enhance cell infiltration, topographical cue and mechanical properties...
September 25, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28944750/microsporidia-obligate-intracellular-pathogens-within-the-fungal-kingdom
#10
Bing Han, Louis M Weiss
Microsporidia are obligate intracellular pathogens related to Fungi. These organisms have a unique invasion organelle, the polar tube, which upon appropriate environmental stimulation rapidly discharges out of the spore, pierces a host cell's membrane, and serves as a conduit for sporoplasm passage into the host cell. Phylogenetic analysis suggests that microsporidia are related to the Fungi, being either a basal branch or sister group. Despite the description of microsporidia over 150 years ago, we still lack an understanding of the mechanism of invasion, including the role of various polar tube proteins, spore wall proteins, and host cell proteins in the formation and function of the invasion synapse...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28944732/patient-centered-drug-approval-the-role-of-patient-advocacy-in-the-drug-approval-process
#11
T Joseph Mattingly, Linda Simoni-Wastila
Recent approval of eteplirsen for Duchenne muscular dystrophy (DMD), a rare disease with few treatment alternatives, has reignited the debate over the U.S. drug approval process. The evolution of legal and regulatory restrictions to the marketing and sale of pharmaceuticals has spanned more than a century, and throughout this history, patient advocacy has played a significant role. Scientific evidence from clinical trials serves as the foundation for drug approval, but the patient voice has become increasingly influential...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944687/heavy-drinking-among-individuals-with-hiv-who-drinks-despite-knowledge-of-the-risk
#12
Jennifer C Elliott, Malka Stohl, Deborah S Hasin
Heavy drinking can cause medical problems for individuals with HIV, and drinking despite medical contraindications indicates problem use. However, little is known about which individuals with HIV drink despite knowledge of health problems. This study utilizes two subsamples of individuals with HIV from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III): those reporting at least one drink (a) in their lifetime (n = 205) or (b) in the past year (n = 166). Participants reported on drinking despite health problems and psychopathology in the past year and in their lifetime, and family history of alcohol problems...
September 25, 2017: AIDS Care
https://www.readbyqxmd.com/read/28944620/intracoronary-snaring-of-the-retrograde-guidewire-how-to-overcome-extreme-takeoff-angles-in-chronic-total-occlusion-percutaneous-coronary-intervention
#13
Lorenzo Azzalini, Luciano Candilio, Mauro Carlino, Antonio Colombo
Extreme angulation of coronary artery takeoff represents a challenge for wiring and device advancement in percutaneous coronary intervention (PCI). This anatomic feature is particularly adverse in cases of chronic total occlusion (CTO) of the ostial-proximal segment of the target vessel. In this setting, the retrograde approach can help getting access to the occlusion. However, difficulties might arise at the critical step of wire externalization, due to the need to overcome the extreme ostial angle. Here, we describe a case of successful CTO PCI of the proximal circumflex artery, which presented an extreme angle at its takeoff...
September 25, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28944569/prognostic-factors-and-treatment-outcomes-for-patients-with-fournier-s-gangrene-a-retrospective-study
#14
Kyung Sook Hong, Hee Jung Yi, Ryung-Ah Lee, Kwang Ho Kim, Soon Sup Chung
Fournier's gangrene is a gas-forming, necrotising soft tissue infection affecting the perineum. It spreads rapidly along the deep fascial planes and is associated with a high mortality rate. With a growing elderly population with comorbidities, the frequency of severe cases of Fournier's gangrene is expected to increase. We retrospectively reviewed 20 patients diagnosed with Fournier's gangrene at our institution from 2003 to 2014 and analysed data. Thirteen patients had diabetes mellitus, two had been diagnosed with liver cirrhosis, and four were chronic alcoholics...
September 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28944512/comprehensive-evaluation-of-decellularized-porcine-corneal-after-clinical-transplantation
#15
Yan Shi, Timur Bikkuzin, Zhen Song, Xin Jin, Hao Jin, Xinlei Li, Hong Zhang
Corneal disease is the second most common blinding disease in the world. The shortage of cornea donors has become the greatest challenge in curing corneal disease. Decellularized porcine corneas have the potential to be clinically applied as a substitute for human cornea in lamellar keratoplasty. Porcine corneas will help relieve the cornea donor shortage. To comprehensively evaluate the characteristics of the grafts and the effect of the decellularized porcine cornea on the host cornea after clinical transplantation, we assessed the microstructure of the transplanted decellularized porcine corneal tissues...
September 24, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28944500/social-cognitive-and-physiological-aspects-of-humour-perception-from-4-to-8-months-two-longitudinal-studies
#16
Gina C Mireault, Susan C Crockenberg, Keri Heilman, John E Sparrow, Kassandra Cousineau, Brady Rainville
Infants laugh by 4 months, but whether they understand humour based on social or cognitive factors is unclear. We conducted two longitudinal studies of 4-, 6-, and 8-month-olds (N = 60), and 5-, 6-, and 7-month-olds (N = 53) to pinpoint the onset of independent humour perception and determine when social and cognitive factors are most salient. Infants were shown six events in randomized repeated-measures designs: two ordinary events and two absurd iterations of those events, with parents' affect manipulated (laugh or neutral) during the latter...
September 25, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28944498/immigrant-health-through-the-lens-of-home-visitors-supervisors-and-administrators-the-florida-maternal-infant-and-early-childhood-home-visiting-program
#17
Esther Jean-Baptiste, Paige Alitz, Pamela C Birriel, Siobhan Davis, Rema Ramakrishnan, Leandra Olson, Jennifer Marshall
OBJECTIVE: The Florida Maternal, Infant, and Early Childhood Home Visiting (MIECHV) program aims to minimize the occurrence of adverse maternal and child health outcomes for mothers deemed at-risk during pregnancy or shortly after childbirth. This study sought to understand the needs of and challenges faced by immigrant families in accessing health care through the perspective of Florida MIECHV home visitors, supervisors, and administrators. DESIGN AND SAMPLE: In this exploratory qualitative study, focus groups were held at each of the Florida MIECHV-funded program sites with a total of 81 MIECHV staff to discuss how the program addresses a range of participant needs...
September 25, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28944461/hearing-aids-for-mild-to-moderate-hearing-loss-in-adults
#18
REVIEW
Melanie A Ferguson, Pádraig T Kitterick, Lee Yee Chong, Mark Edmondson-Jones, Fiona Barker, Derek J Hoare
BACKGROUND: The main clinical intervention for mild to moderate hearing loss is the provision of hearing aids. These are routinely offered and fitted to those who seek help for hearing difficulties. By amplifying and improving access to sounds, and speech sounds in particular, the aim of hearing aid use is to reduce the negative consequences of hearing loss and improve participation in everyday life. OBJECTIVES: To evaluate the effects of hearing aids for mild to moderate hearing loss in adults...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944443/the-relationship-between-self-reported-borderline-personality-features-and-prospective-illness-course-in-bipolar-disorder
#19
Georg Riemann, Nadine Weisscher, Robert M Post, Lori Altshuler, Susan McElroy, Marc A Frye, Paul E Keck, Gabriele S Leverich, Trisha Suppes, Heinz Grunze, Willem A Nolen, Ralph W Kupka
BACKGROUND: Although bipolar disorder (BD) and borderline personality disorder (BPD) share clinical characteristics and frequently co-occur, their interrelationship is controversial. Especially, the differentiation of rapid cycling BD and BPD can be troublesome. This study investigates the relationship between borderline personality features (BPF) and prospective illness course in patients with BD, and explores the effects of current mood state on self-reported BPF profiles. METHODS: The study included 375 patients who participated in the former Stanley Foundation Bipolar Network...
September 25, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28944435/reduction-melting-extraction-of-trace-elements-from-hazardous-waste-glass-from-an-old-glasswork-s-dump-in-the-southeastern-part-of-sweden
#20
Yahya Jani, William Hogland
At the southeastern part of Sweden, old art and crystal waste glass has been identified as a hazardous waste due to high weight concentrations of Pb (32.398%), Cd (0.085%), and As (1.976%). The reduction-melting technique was used to investigate the extraction of these trace elements from powder waste glass of particle size < 1 mm. Following a factorial design technique, the experimental results of the reduction-melting method showed that 99.9% of Pb, 100% of Cd, and 99% of As could be extracted. For a batch of 10 g powder waste glass, the found experimental and theoretical optimum operating conditions were 1100 °C of melting temperature, 5 g of Na2CO3, 2 g of carbon, and 120 min of melting time...
September 24, 2017: Environmental Science and Pollution Research International
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