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https://www.readbyqxmd.com/read/29783210/the-effectiveness-of-sphero-cylindrical-correction-at-a-short-distance-in-presbyopic-age-patients-with-the-first-detected-astigmatism
#1
Iryna M Bezkorovayna, Victoria V Ryadnova, Denys O Nakonechnyi, Anna O Bezkorovayna
OBJECTIVE: Introduction: The practical results of optical correction without considering the cylindrical component at close dictance do not always satisfy the patient in everyday visual activity. The aim: Compare the effect of sphero-cylindrical and spherical correction in presbyopic patients with the first detected astigmatism at a close distance work. PATIENTS AND METHODS: Materials and methods: The article presents the results of a survey of 43 patients (86 eyes) aged 38 to 59 years, on average 47 ± 0...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782973/enhanced-retinal-pigment-epithelium-rpe-regeneration-using-curcumin-alginate-hydrogels-in-vitro-evaluation
#2
Jong Ho Park, Eun Yeong Shin, Myeong Eun Shin, Min Joung Choi, Cristiano Carlomagno, Jeong Eun Song, Gilson Khang
The retinal pigment epithelium (RPE) plays a significant role in retaining structural integrity of eye. Factors such as reduction in cell regeneration due to aging and physical injury pose a major hurdle in RPE regeneration. In this study, we exploited the use of alginate (AGT) incorporated with Curcumin (CCI) forming a hydrogel based system CCI/AGT. The fabricated hydrogel could anchor RPE cell in it. In vitro cell analysis revealed that the CCI/AGT hydrogel shows good biocompatibility, enhanced cell growth ability and higher ECM formation compared to the pure AGT hydrogel...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782944/a-comprehensive-review-on-contact-lens-for-ophthalmic-drug-delivery
#3
REVIEW
Jiawen Xu, Yingyan Xue, Gaoyong Hu, Tianyu Lin, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang
With the prevalence of electronic devices and an aging population, the number of people affected with eye disease is increasing year by year. In spite of a large number of eye drops on the market, most of them do not perform sufficiently, due to rapid clearance mechanisms and ocular barriers. To enhance drug delivery to the eye, a number of novel formulations for ocular diseases have been investigated over recent decades, aiming to increase drug retention and permeation while also allowing for sustained drug release over prolonged periods...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29782826/sheets-of-human-retinal-progenitor-transplants-improve-vision-in-rats-with-severe-retinal-degeneration
#4
Bin Lin, Bryce T McLelland, Anuradha Mathur, Robert B Aramant, Magdalene J Seiler
Loss of photoreceptors and other retinal cells is a common endpoint in retinal degenerate (RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace damaged retinal cells and improve vision. In this study, we examined the development of human fetal retinal sheets with or without their retinal pigment epithelium (RPE) transplanted to immunodeficient retinal degenerate rho S334ter-3 rats. Sheets were dissected from fetal human eyes (11-15.7 weeks gestation) and then transplanted to the subretinal space of 24-31 d old RD nude rats...
May 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29782817/evolution-of-the-developmental-plasticity-and-a-coupling-between-left-mechanosensory-neuromasts-and-an-adaptive-foraging-behavior
#5
Vânia Filipa Lima Fernandes, Christian Macaspac, Louise Lu, Masato Yoshizawa
Many animal species exhibit laterality in sensation and behavioral responses, namely, the preference for using either the left or right side of the sensory system. For example, some fish use their left eye when observing social stimuli, whereas they use their right eye to observe novel objects. However, it is largely unknown whether such laterality in sensory-behavior coupling evolves during rapid adaptation processes. Here, in the Mexican tetra, Astyanax mexicanus, we investigate the laterality in the relationship between an evolved adaptive behavior, vibration attraction behavior (VAB), and its main sensors, mechanosensory neuromasts...
May 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29782814/primary-assessment-of-the-patient-with-orbital-fractures-should-include-pupillary-response-and-visual-acuity-changes-to-detect-occult-major-ocular-injuries
#6
Jeffrey Chow, Krishnan Parthasarathi, Patrick Mehanna, Eline Whist
PURPOSE: Sight-threatening injuries associated with orbital fractures are of major concern to maxillofacial surgeons whom are often the first asked to assess these patients. Eliciting signs and symptoms that are predictive of these injuries would allow expedited ophthalmic consultation and appropriate management. We hypothesized that abnormal pupillary response is predictive of major ocular injuries. PATIENTS AND METHODS: A retrospective cohort study of patients with facial fractures was instituted with review of all associated ophthalmic injuries...
May 1, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29782497/exploration-of-alternative-test-methods-to-evaluate-phototoxicity-of-ophthalmic-agents-by-using-statens-seruminstitut-rabbit-cornea-cell-lines-and-3d-human-reconstituted-cornea-models
#7
Soyoung Kim, Ki Hwan Choi, Jaesuk Yun
Many chemicals have been reported to induce phototoxicity. The absorbance of light energy within the sunlight range is a common characteristic of phototoxicity. The 3T3 NRU phototoxicity test (PT) in 3T3 mouse skin fibroblasts has been used to identify the phototoxic potential induced by excited chemicals after exposure to ultra violet (UV). However, as phototoxicity may occur in ocular cells, it is necessary to develop a more suitable test for cornea-derived cells. In this study, we attempted to establish a new in vitro PT method in rabbit corneal cell lines (SIRC)...
2018: PloS One
https://www.readbyqxmd.com/read/29782336/a-review-of-small-incision-lenticule-extraction-complications
#8
Ronald R Krueger, Caio S Meister
PURPOSE OF REVIEW: As a flapless procedure, SMILE brings benefits to refractive surgery, such as lower corneal biomechanical impact, less dry eye risk and less stromal bed exposure. However, the longer learning curve can be a risk factor for complications. This article aims to discuss SMILE complications and proposes a categorized analysis of occurrences, dividing into two groups: intraoperative and postoperative complications. Among intraoperative, we also suggest a subdivision between those related to the laser (lenticule construction), tissue separation (lenticule dissection) and tissue removal (lenticule extraction)...
May 17, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29782325/early-emotional-attention-is-impacted-in-alzheimer-s-disease-an-eye-tracking-study
#9
Jessica Bourgin, Nathalie Guyader, Alan Chauvin, Alexandra Juphard, Mathilde Sauvée, Olivier Moreaud, Laetitia Silvert, Pascal Hot
Emotional deficits have been repetitively reported in Alzheimer's disease (AD) without clearly identifying how emotional processing is impaired in this pathology. This paper describes an investigation of early emotional processing, as measured by the effects of emotional visual stimuli on a saccadic task involving both pro (PS) and anti (AS) saccades. Sixteen patients with AD and 25 age-matched healthy controls were eye-tracked while they had to quickly move their gaze toward a positive, negative, or neutral image presented on a computer screen (in the PS condition) or away from the image (in the AS condition)...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29782196/a-randomized-clinical-trial-of-topical-diclofenac-fluorometholone-and-dexamethasone-for-control-of-inflammation-after-strabismus-surgery
#10
Jinsoo Kim, Dong Chul Choi, Seokhyun Bae, Dong Gyu Choi, Joo Yeon Lee
PURPOSE: To evaluate the comparative effects and safety of topical diclofenac sodium, fluorometholone, and dexamethasone for controlling inflammation after routine strabismus surgery. METHODS: This was a randomized clinical trial. Ninety-nine patients admitted for surgery to treat intermittent exotropia were randomly assigned to receive 1 of 3 postoperative eye drops between January 2015 and February 2016. The primary efficacy outcomes were pain and conjunctival injection...
May 21, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29782067/sublingual-immunotherapy-for-pediatric-allergic-conjunctivitis-a-meta-analysis-of-randomized-controlled-trials
#11
Jie Yang, Li Zhang, Zhixiang Zhao, Shiyu Liao
BACKGROUND: Allergic conjunctivitis (AC) is a common chronic condition, especially in children. Ocular symptoms are often overlooked during treatment of allergic rhinoconjunctivitis (ARC). Pediatric ARC can be effectively treated using sublingual immunotherapy (SLIT), which is a guideline-recommended safe treatment approach. However, the therapeutic efficacy of SLIT in terms of ameliorating eye symptoms has not been effectively evaluated. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) evaluating the use of SLIT for infants, children, and adolescents (aged from 3 to 18 years) with AC or ARC...
May 21, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29781976/posterior-scleral-contraction-to-treat-recurrent-or-persistent-macular-detachment-after-previous-vitrectomy-in-highly-myopic-eyes
#12
Linyan Zheng, Anpeng Pan, Shuangqian Zhu, Yue Wu, Liang Dong, Anquan Xue
PURPOSE: To determine the efficacy of posterior scleral contraction (PSC) to treat recurrent or persistent macular detachment after previous vitrectomy in highly myopic eyes. METHODS: We reviewed the medical records of patients with high myopia and recurrent or persistent macular detachment after previous vitrectomy treated with PSC at our hospital between April 2013 and March 2017. Fourteen eyes (14 patients; mean age, 58.93 ± 11.08 years) were included. Sclera cross-linked with genipin was used for PSC...
May 16, 2018: Retina
https://www.readbyqxmd.com/read/29781975/novel-best1-mutations-detected-by-next-generation-sequencing-in-a-chinese-population-with-vitelliform-macular-dystrophy
#13
Jingli Guo, Fengjuan Gao, Wenyi Tang, Yuhe Qi, Yi Xuan, Wei Liu, Lei Li, Xiaofeng Ye, Gezhi Xu, Jihong Wu, Yongjin Zhang
PURPOSE: To characterize novel BEST1 mutations and the phenotype-genotype correlations in vitelliform macular dystrophy in a Chinese population. METHODS: Seventeen individuals affected by vitelliform macular dystrophy underwent detailed ophthalmic examinations, including a best-corrected visual acuity test, slit-lamp biomicroscopy, fundus photography, spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and optical coherence tomography angiography...
May 16, 2018: Retina
https://www.readbyqxmd.com/read/29781974/prognostic-value-of-shape-descriptive-factors-for-the-progression-of-geographic-atrophy-secondary-to-age-related-macular-degeneration
#14
Maximilian Pfau, Moritz Lindner, Lukas Goerdt, Sarah Thiele, Jennifer Nadal, Matthias Schmid, Steffen Schmitz-Valckenberg, SriniVas R Sadda, Frank G Holz, Monika Fleckenstein
PURPOSE: To systematically compare the prognostic value of multiple shape-descriptive factors in the natural course of the disease. METHODS: A total of 296 eyes of 201 patients (female patients 130; mean age: 72.2 ± 13.08 years) with a median follow-up of 2.38 years from 2 prospective, noninterventional natural history studies (Fundus-Autofluorescence-in-Age-related-Macular-Degeneration [clinicaltrials.gov identifier NCT00393692], Directional-Spread-in-Geographic-Atrophy [NCT02051998]) were included in the analysis...
May 16, 2018: Retina
https://www.readbyqxmd.com/read/29781927/a-case-of-corneal-neovascularization-misdiagnosed-as-total-limbal-stem-cell-deficiency
#15
Qihua Le, C Michael Samson, Sophie X Deng
PURPOSE: To report a case of corneal neovascularization misdiagnosed as total limbal stem cell deficiency (LSCD). METHODS: This is a case report of a 61-year-old woman who has a history of bilateral idiopathic scleritis, keratitis, and uveitis for more than 20 years. She was diagnosed with total LSCD in her left eye based on clinical presentation alone and was confirmed as a candidate for limbal transplantation at several major tertiary eye care centers in the United States...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29781926/repeatability-and-intersession-reproducibility-of-pentacam-corneal-thickness-maps-in-fuchs-dystrophy-and-endothelial-keratoplasty
#16
David Mingo-Botín, Francisco Arnalich-Montiel, Ana Couceiro de Juan, Sara Ortiz-Toquero
PURPOSE: To assess intrasession repeatability and intersession reproducibility of Pentacam corneal thickness maps in patients with Fuchs endothelial corneal dystrophy (FECD) before and after endothelial transplantation. METHODS: In this observational diagnostic evaluation, 20 healthy subjects along with 81 consecutive patients were examined. Patients were classified into 4 groups: FECD without corneal edema, FECD with corneal edema, Descemet stripping automated endothelial keratoplasty, and Descemet membrane endothelial keratoplasty...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29781925/osteo-odonto-keratoprosthesis-in-severe-thermal-and-chemical-injuries
#17
Alfonso Vasquez-Perez, Mehran Zarei-Ghanavati, Venkata Avadhanam, Christopher Liu
PURPOSE: To report the results of osteo-odonto-keratoprosthesis (OOKP) surgery in patients who sustained severe chemical and thermal injuries. METHODS: This is a noncomparative retrospective case series of 14 patients who underwent OOKP surgery between 2001 and 2016 at the Sussex Eye Hospital, Brighton, UK, because of severe chemical and thermal injuries RESULTS:: OOKP surgery was performed in 14 eyes of 14 patients. Eight patients (57%) sustained thermal injuries and 6 patients (43%) chemical injuries...
May 16, 2018: Cornea
https://www.readbyqxmd.com/read/29781873/case-report-use-of-sports-and-performance-vision-training-to-benefit-a-low-vision-patient-s-function
#18
Daniel M Laby
SIGNIFICANCE: Despite our inability to attenuate the course of many ocular diseases that can ultimately lead to loss or significantly decreased visual function, this report describes a potential technique to aid such patients in maximizing the use of the vision that remains. PURPOSE: The aim of this study was to demonstrate the applicability of utilizing sports vision training to improve objective and subjective visuomotor function in a low-vision patient. CASE REPORT: A 37-year-old woman with Usher syndrome presented with reduced central visual acuity and visual field...
May 17, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29781835/deep-learning-classifier-with-an-ultra-wide-field-scanning-laser-ophthalmoscope-detects-glaucoma-visual-field-severity
#19
Masumoto Hiroki, Hitoshi Tabuchi, Shunsuke Nakakura, Ishitobi Naofumi, Masayuki Miki, Enno Hiroki
PURPOSE: To evaluate the accuracy of detecting glaucoma visual field defect severity using deep-learning classifier (DL) with an ultra-wide-field scanning laser ophthalmoscope. METHODS: One eye of 982 open angle glaucoma (OAG) patients and 417 healthy eyes were enrolled. We categorized glaucoma patients into three groups according to the glaucoma visual field damage (Humphrey Field Analyzer 24-2 program) (early; -6▒dB (mean deviation) or better, moderate; between -6 and -12▒dB, and severe as mean deviation of -12▒dB or worse)...
May 17, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29781833/influence-of-socio-demographic-factors-on-disease-characteristics-and-vision-related-quality-of-life-in-primary-open-angle-glaucoma-patients-the-italian-primary-open-angle-glaucoma-study-ipoags
#20
Ivano Riva, Lorenzo Legramandi, Andreas Katsanos, Francesco Oddone, Eliana Rulli, Gloria Roberti, Luciano Quaranta
PURPOSE: To evaluate the potential association between socio-demographic factors with clinical characteristics, vision-related quality of life and glaucoma-related symptoms scores in a large cohort of primary open angle glaucoma (POAG) patients. MATERIAL AND METHODS: Multicenter, cross-sectional study involving academic and non-academic centers. Previously diagnosed POAG patients aged >18 years were enrolled. At baseline, information on demographic characteristics, social, medical and ocular history, clinical presentation and treatments was collected...
May 17, 2018: Journal of Glaucoma
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