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JOURNAL ARTICLE
L N Maslov, A V Krylatov, N V Naryzhaia, N V Solenkova, A Iu Lishmanov, S A Bogomaz, G J Gross, J B Stefano, B A Loktiushina
It has been shown that mu-opioid receptor stimulation by intravenous administration of the selective mu receptor agonist DALDA in a dose of 0.1 mg/kg prevented ischemic and reperfusion arrhythmias in rats subjected to coronary artery occlusion (10 min) and reperfusion (10 min), and also increased the ventricular fibrillation threshold in rats with postinfarction cardiac fibrosis. These effects were abolished by pre-treatment with the selective mu receptor antagonist CTAP in a dose of 0.5 mg/kg or by prior injection of the opioid receptor antagonist naloxone methiodide (2 mg/kg) which does not penetrate the blood-braib barrier...
July 2002: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
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