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Ekatherine Prokopiou, Panagiotis Kolovos, Maria Kalogerou, Anastasia Neokleous, Orthodoxia Nicolaou, Kleitos Sokratous, Kyriacos Kyriacou, Tassos Georgiou
Purpose: To evaluate the therapeutic effects of omega-3 (ω3) fatty acids on retinal degeneration in the ABCA4-/- model of Stargardt disease when the blood level of arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio is between 1 and 1.5. Methods: Eight-month-old mice were allocated to three groups: wild type (129S1), ABCA4-/- untreated, and ABCA4-/- ω3 treated. ω3 treatment lasted 3 months and comprised daily gavage administration of EPA and docosahexaenoic acid (DHA)...
June 1, 2018: Investigative Ophthalmology & Visual Science
Tassos Georgiou, Yao-Tseng Wen, Chung-Hsing Chang, Panagiotis Kolovos, Maria Kalogerou, Ekatherine Prokopiou, Anastasia Neokleous, Chin-Te Huang, Rong-Kung Tsai
Purpose: The purpose of this study was to investigate the therapeutic effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) administration in a rat model of anterior ischemic optic neuropathy (rAION). Methods: The level of blood arachidonic acid/eicosapentaenoic acid (AA/EPA) was measured to determine the suggested dosage. The rAION-induced rats were administered fish oil (1 g/day EPA) or phosphate-buffered saline (PBS) by daily gavage for 10 consecutive days to evaluate the neuroprotective effects...
March 1, 2017: Investigative Ophthalmology & Visual Science
Michael D Diamantidis, Nikolaos Neokleous, Aleka Agapidou, Evaggelia Vetsiou, Achilles Manafas, Paraskevi Fotiou, Efthymia Vlachaki
The life expectancy of thalassemic patients has increased, and now approaches that of healthy individuals, thanks to improved treatment regimens. However, pregnancy in women with β-Thalassemia Μajor remains a challenging condition. Recent advances in managing this haemoglobinopathy offer the potential for safe pregnancies with favorable outcome. However, clinical data regarding the use of chelation therapy during pregnancy are limited, and it is unclear whether these agents impose any risk to the developing fetus...
May 2016: International Journal of Hematology
Kleanthis Neokleous, Andria Shimi, Marios N Avraamides
A computational model of visual selective attention has been implemented to account for experimental findings on the Perceptual Load Theory (PLT) of attention. The model was designed based on existing neurophysiological findings on attentional processes with the objective to offer an explicit and biologically plausible formulation of PLT. Simulation results verified that the proposed model is capable of capturing the basic pattern of results that support the PLT as well as findings that are considered contradictory to the theory...
2016: Frontiers in Psychology
M S Neofytou, K Neokleous, A Aristodemou, I Constantinou, Z Antoniou, E C Schiza, C S Pattichis, C N Schizas
There is a huge need for open source software solutions in the healthcare domain, given the flexibility, interoperability and resource savings characteristics they offer. In this context, this paper presents the development of three open source libraries - Specific Enablers (SEs) for eHealth applications that were developed under the European project titled "Future Internet Social and Technological Alignment Research" (FI-STAR) funded under the "Future Internet Public Private Partnership" (FI-PPP) program...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Eirini C Schiza, Kleanthis C Neokleous, Nikolai Petkov, Christos N Schizas
BACKGROUND: Medical practice and patient-doctor relationship will continue improving while technology is integrated in our everyday life. In recent years the term eHealth landmarked a new era with improved health provider's skills and knowledge, and increased patient participation in medical care activities. OBJECTIVE: To show why the design and implementation of a healthcare system needs to follow a specific philosophy dictated by the level of eHealth maturity of a country and its citizens...
2015: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Zinonas Antoniou, Eirini C Schiza, Kleanthis Neokleous, Michael Angastiniotis, Constantinos S Pattichis, Christos N Schizas
This paper presents an electronic registry system for the purposes of the eENERCA for rare congenital conditions that require lifelong follow up and treatment. The main objective of the eENERCA project focusses on the prevention of major rare anaemias (RAs) by facilitating the access, at a European level, to the best genetic counselling, diagnosis and clinical management of the patients with RA independently of their country of origin. This can be achieved by promoting an extension of the full Electronic Health Record system and specifically the electronic registries for RAs, across Europe for the purposes stated hence promoting service development for the benefit of patients...
2015: Studies in Health Technology and Informatics
Efthymia Vlachaki, Nikolaos Neokleous, Dimitra Paspali, Evaggelia Vetsiou, Elias Onoufriadis, Nicolaos Sousos, Sofia Hissan, Sofia Vakalopoulou, Vasilia Garypidou, Panagiota Boura
β-Thalassemia major (β-TM) is a chronic, genetic blood disorder. Patients are considered to be vulnerable to emotional and behavioral problems. The aim of this study was to assess mental health and somatic pain of patients with homozygous β-TM, who are systematically transfused in our unit. In this survey, 54 adult patients were studied. The general health questionnaire (GHQ-28) was used as mental health assessment model aimed at detecting mental disorders. The model of Binary was used as scoring method of GHQ-28...
2015: Hemoglobin
Chrystalla Prokopiou, Sotiris Koumas, Nikolaos Neokleous, Ourania Seimeni, Aikaterini Barmpouti
No abstract text is available yet for this article.
June 18, 2015: Leukemia & Lymphoma
Efthymia Vlachaki, Aleka Agapidou, Nikolaos Neokleous, Despoina Adamidou, Evaggelia Vetsiou, Panagiota Boura
The diagnosis of thrombotic thrombocytopenic purpura is one of the possible diagnosis when a patient is admitted with unexpected micro-angiopathic hemolytic anemia and thrombocytopenia. The combination of sickle cell/β(+)-thalassemia and thrombotic thrombocytopenic purpura is rare and triggering. This article describes the poor outcome of a patient with sickle cell/β(+)-thalassemia presenting with gingival bleeding, severe thrombocytopenia and anemia. The patient had normal renal function, no neurological deficit and he was initially treated as immune thrombocytopenic purpura...
October 2014: Transfusion and Apheresis Science
Kleanthis C Neokleous, Eirini C Schiza, Constantinos S Pattichis, Christos N Schizas
The design and implementation of a healthcare system needs to follow a specific philosophy regarding its operational structure and must be adapted gradually with one step at a time, depending on the level of maturity of a country on certain key issues. The main goal of this paper is to present an overall recommendations framework for implementing an Electronic Health System at national level, guided by the Patient Centered Philosophy. Certain prerequisites for implementing such systems are analyzed together with guiding principles for identifying the maturity level of an organization or country...
2014: Studies in Health Technology and Informatics
Efthymia Vlachaki, Panagiotis Andreadis, Nikolaos Neokleous, Aleka Agapidou, Evaggelia Vetsiou, Panagiotis Katsinelos, Panagiota Boura
Sickle cell/β (+) thalassemia (Hb S/β (+)thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/β (+)thal usually have a mild type of disease, herein we describe an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/β (+)thal...
2014: Case Reports in Hematology
S Theodoridou, M Economou, T-A Vyzantiadis, A Teli, E Vlachaki, N Neokleous, A Kargioti, S Vakalopoulou, V Garypidou, N Gombakis, F Papachristou
The aim of this study was to investigate platelet function in patients with thalassaemia and to detect any relation to chelation treatment (deferasirox or deferiprone/deferiprone plus desferioxamine). Thirty-three transfusion-dependent patients with thalassaemia were included. The investigation consisted of aggregation testing of platelet-rich plasma by light transmission aggregometry (LTA) with the use of 5 agonists as well as the global test of haemostasis by means of the PFA-100 platelet function analyser...
2014: Acta Haematologica
E Vlachaki, A Kalogeridis, N Neokleous, V Perifanis, F Klonizakis, E Ioannidou, I Klonizakis
The report of Janus Kinase 2 (JAK2) mutations in myeloid malignancies with high frequency in myeloproliferative neoplasms has been well known since 2005. By monitoring allele burden, it is found that the expression of JAK2V617F mutation is increasing significantly from essential thrombocytosis to polycythemia vera. Furthermore, JAK2 abnormalities are reported in the majority of unexplained thrombotic episodes. Thalassemic syndromes are characterized by ineffective erythropoiesis and thrombocytosis, mainly due to splenectomy...
May 2012: Molecular Biology Reports
Nikolaos Neokleous, Anastasia Sideri, Corina Peste-Tsilimidos
Over the last two decades umbilical cord blood (UCB) transplantation (UCBT) is increasingly used for a variety of malignant and benign hematological and other diseases. The main factor that limits the use of UCB to low weight recipients, mainly children and adolescents, is its low progenitor cell content. Various alternatives have been exploited to overcome this difficulty, including the transplantation of two UCB units (double umbilical cord blood transplantation, dUCBT). Following dUCBT, donor(s) hematopoietic stem cells (HSC) can be detected in the peripheral blood of the recipient as soon as 14 days post-transplantation...
January 13, 2011: Hematology Reports
Anastasia Sideri, Nikolaos Neokleous, Philippe Brunet De La Grange, Bernadette Guerton, Marie-Caroline Le Bousse Kerdilles, Georges Uzan, Corina Peste-Tsilimidos, Eliane Gluckman
Umbilical cord blood transplantation has been increasingly used over the past years for both malignant and non-malignant hematologic and other diseases as an alternative to mismatched-related or matched-unrelated bone marrow or peripheral blood hematopoietic stem cell transplantation. A disadvantage of cord blood is its low cell content which limits cord blood transplantation to generally low weight recipients, such as children. Various alternatives have been used to overcome this limitation, including co-infusion of two partially HLA-matched cord blood units...
August 2011: Haematologica
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