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canine distemper virus

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https://www.readbyqxmd.com/read/28532806/a-molecular-survey-for-selected-viral-enteropathogens-revealed-a-limited-role-of-canine-circovirus-in-the-development-of-canine-acute-gastroenteritis
#1
Giulia Dowgier, Eleonora Lorusso, Nicola Decaro, Costantina Desario, Viviana Mari, Maria Stella Lucente, Gianvito Lanave, Canio Buonavoglia, Gabriella Elia
Canine circovirus (CanineCV) is a canine virus, whose pathogenetic role is still uncertain. Based on recent data suggesting its role as entheropathogen, a case-control study was conducted between 2013 and 2016 to investigate the association of CanineCV with gastroenteritis in dogs, alone or in combination with other viral pathogens, including canine parvovirus (CPV), canine coronavirus (CCoV) and canine distemper virus (CDV). A total of 219 dogs suffering from acute gastroenteritis disorders and 67 controls randomly recruited among healthy dogs or patients presenting without enteric signs were screened by a panel of real-time (RT-)PCR assays for CanineCV, CPV, CCoV and CDV...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28481926/delineating-morbillivirus-entry-dissemination-and-airborne-transmission-by-studying-in-vivo-competition-of-multicolor-canine-distemper-viruses-in-ferrets
#2
Rory D de Vries, Martin Ludlow, Alwin de Jong, Linda J Rennick, R Joyce Verburgh, Geert van Amerongen, Debby van Riel, Peter R W A van Run, Sander Herfst, Thijs Kuiken, Ron A M Fouchier, Albert D M E Osterhaus, Rik L de Swart, W Paul Duprex
Identification of cellular receptors and characterization of viral tropism in animal models have vastly improved our understanding of morbillivirus pathogenesis. However, specific aspects of viral entry, dissemination and transmission remain difficult to recapitulate in animal models. Here, we used three virologically identical but phenotypically distinct recombinant (r) canine distemper viruses (CDV) expressing different fluorescent reporter proteins for in vivo competition and airborne transmission studies in ferrets (Mustela putorius furo)...
May 8, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28472594/development-and-characterization-of-canine-distemper-virus-monoclonal-antibodies
#3
Yuxiu Liu, Liying Hao, Xiangdong Li, Linxiao Wang, Jianpo Zhang, Junhua Deng, Kegong Tian
Five canine distemper virus monoclonal antibodies were developed by immunizing BALB/c mice with a traditional vaccine strain Snyder Hill. Among these monoclonal antibodies, four antibodies recognized both field and vaccine strains of canine distemper virus without neutralizing ability. One monoclonal antibody, 1A4, against hemagglutinin protein of canine distemper virus was found to react only with vaccine strain virus but not field isolates, and showed neutralizing activity to vaccine strain virus. These monoclonal antibodies could be very useful tools in the study of the pathogenesis of canine distemper virus and the development of diagnostic reagents...
May 4, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/28399176/pathological-findings-in-the-red-fox-vulpes-vulpes-stone-marten-martes-foina-and-raccoon-dog-nyctereutes-procyonoides-with-special-emphasis-on-infectious-and-zoonotic-agents-in-northern-germany
#4
Charlotte Lempp, Nicole Jungwirth, Miguel L Grilo, Anja Reckendorf, Arlena Ulrich, Abbo van Neer, Rogier Bodewes, Vanessa M Pfankuche, Christian Bauer, Albert D M E Osterhaus, Wolfgang Baumgärtner, Ursula Siebert
Anthropogenic landscape changes contributed to the reduction of availability of habitats to wild animals. Hence, the presence of wild terrestrial carnivores in urban and peri-urban sites has increased considerably over the years implying an increased risk of interspecies spillover of infectious diseases and the transmission of zoonoses. The present study provides a detailed characterisation of the health status of the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides) in their natural rural and peri-urban habitats in Schleswig-Holstein, Germany between November 2013 and January 2016 with focus on zoonoses and infectious diseases that are potentially threatening to other wildlife or domestic animal species...
2017: PloS One
https://www.readbyqxmd.com/read/28394936/homologous-recombination-is-a-force-in-the-evolution-of-canine-distemper-virus
#5
Chaowen Yuan, Wenxin Liu, Yingbo Wang, Jinlong Hou, Liguo Zhang, Guoqing Wang
Canine distemper virus (CDV) is the causative agent of canine distemper (CD) that is a highly contagious, lethal, multisystemic viral disease of receptive carnivores. The prevalence of CDV is a major concern in susceptible animals. Presently, it is unclear whether intragenic recombination can contribute to gene mutations and segment reassortment in the virus. In this study, 25 full-length CDV genome sequences were subjected to phylogenetic and recombinational analyses. The results of phylogenetic analysis, intragenic recombination, and nucleotide selection pressure indicated that mutation and recombination occurred in the six individual genes segment (H, F, P, N, L, M) of the CDV genome...
2017: PloS One
https://www.readbyqxmd.com/read/28361207/antibody-response-to-paramyxoviruses-in-paget-s-disease-of-bone
#6
Micaela Rios Visconti, Ricardo Usategui-Martín, Stuart H Ralston
Paget's disease of bone (PDB) is a common skeletal disorder characterised by focal abnormalities of increased and disorganised bone turnover. Genetic factors play a central role in the pathogenesis of PDB but environmental factors also contribute. Measles virus (MV), respiratory syncytial virus (RSV) and canine distemper virus (CDV) have all been implicated as potential disease triggers but the data are conflicting. Since chronic paramyxovirus infection with measles is known to be accompanied by increased production of antiviral antibodies, we have analysed circulating concentrations of antibodies to MV, CDV, and RSV as well as mumps, rubella and varicella zoster virus (VZV) in 463 patients with PDB and 220 aged and gender-matched controls...
March 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28349355/polymerase-spiral-reaction-psr-a-novel-visual-isothermal-amplification-method-for-detection-of-canine-parvovirus-2-genomic-dna
#7
Vikas Gupta, Soumendu Chakravarti, Vishal Chander, Saurabh Majumder, Shabir Ahmad Bhat, Vivek Kumar Gupta, Sukdeb Nandi
Canine parvovirus-2 (CPV-2), which is ubiquitously distributed worldwide, causes severe and often fatal gastroenteritis in dogs. Accurate, differential and rapid diagnosis of canine parvoviral enteritis remains a challenge for clinicians. A recently developed isothermal amplification technique, polymerase spiral reaction (PSR), was optimized for the first time for a viral pathogen with reference recombinant plasmid standards from different CPV-2 antigenic variants (CPV-2, CPV-2a, CPV-2b and CPV-2c) and subsequently validated using clinical samples...
March 27, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28336928/expression-of-canine-distemper-virus-receptor-nectin-4-in-the-central-nervous-system-of-dogs
#8
Watanyoo Pratakpiriya, Angeline Ping Ping Teh, Araya Radtanakatikanon, Nopadon Pirarat, Nguyen Thi Lan, Makoto Takeda, Somporn Techangamsuwan, Ryoji Yamaguchi
Canine distemper virus (CDV) exhibits lymphotropic, epitheliotropic, and neurotropic nature, and causes a severe systemic infection in susceptible animals. Initially, signaling lymphocyte activation molecule (SLAM) expressed on immune cells has been identified as a crucial cellular receptor for CDV. Currently, nectin-4 expressed in epithelia has been shown to be another receptor for CDV. Our previous study demonstrated that neurons express nectin-4 and are infected with CDV. In this study, we investigated the distribution pattern of nectin-4 in various cell types in the canine central nervous system and showed its relation to CDV infection to further clarify the pathology of disease...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192048/a-serosurvey-of-diseases-of-free-ranging-gray-wolves-canis-lupus-in-minnesota
#9
Michelle Carstensen, John H Giudice, Erik C Hildebrand, J P Dubey, John Erb, Dan Stark, John Hart, Shannon Barber-Meyer, L David Mech, Steve K Windels, Andrew J Edwards
We tested serum samples from 387 free-ranging wolves ( Canis lupus ) from 2007 to 2013 for exposure to eight canid pathogens to establish baseline data on disease prevalence and spatial distribution in Minnesota's wolf population. We found high exposure to canine adenoviruses 1 and 2 (88% adults, 45% pups), canine parvovirus (82% adults, 24% pups), and Lyme disease (76% adults, 39% pups). Sixty-six percent of adults and 36% of pups exhibited exposure to the protozoan parasite Neospora caninum . Exposure to arboviruses was confirmed, including West Nile virus (37% adults, 18% pups) and eastern equine encephalitis (3% adults)...
February 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28148801/inactivated-recombinant-rabies-viruses-displaying-canine-distemper-virus-glycoproteins-induce-protective-immunity-against-both-pathogens
#10
Renata da Fontoura Budaszewski, Andrew Hudacek, Bevan Sawatsky, Beate Krämer, Xiangping Yin, Matthias J Schnell, Veronika von Messling
The development of multivalent vaccines is an attractive methodology for the simultaneous prevention of several infectious diseases in vulnerable populations. Both canine distemper virus (CDV) and rabies virus (RABV) cause lethal disease in wild and domestic carnivores. While RABV vaccines are inactivated, the live-attenuated CDV vaccines retain residual virulence for highly susceptible wildlife species. In this study, we developed recombinant bivalent vaccine candidates based on recombinant vaccine strain rabies virus particles, which concurrently display the protective CDV and RABV glycoprotein antigens...
April 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28135131/health-survey-of-free-ranging-raccoons-procyon-lotor-in-central-park-new-york-new-york-usa-implications-for-human-and-domestic-animal-health
#11
Kimberly L Rainwater, Krysten Marchese, Sally Slavinski, Lee A Humberg, Edward J Dubovi, Jodie A Jarvis, Denise McAloose, Paul P Calle
We conducted health assessments on 113 free-ranging raccoons ( Procyon lotor ) in Central Park, New York City, US, in February 2010, September 2010, and November 2011 in conjunction with a trap-vaccinate-release program to control a raccoon rabies epizootic. Five individuals were sampled at two time points for 118 raccoon examinations in total. We tested 13 of 13 and 8 of 13 euthanized raccoons for rabies and canine distemper virus (CDV), respectively, by antigen testing on brain tissue; all were negative for both viruses...
April 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28051146/impacts-of-canine-distemper-virus-infection-on-the-giant-panda-population-from-the-perspective-of-gut-microbiota
#12
Na Zhao, Meng Li, Jing Luo, Supen Wang, Shelan Liu, Shan Wang, Wenting Lyu, Lin Chen, Wen Su, Hua Ding, Hongxuan He
The recent increase in infectious disease outbreaks has been directly linked to the global loss of biodiversity and the decline of some endangered species populations. Between December 2014 and March 2015, five captive giant pandas died due to canine distemper virus (CDV) infection in China. CDV has taken a heavy toll on tigers and lions in recent years. Here, we describe the first gut microbiome diversity study of CDV-infected pandas. By investigating the influence of CDV infection on gut bacterial communities in infected and uninfected individuals and throughout the course of infection, we found that CDV infection distorted the gut microbiota composition by reducing the prevalence of the dominant genera, Escherichia and Clostridium, and increasing microbial diversity...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28018332/commentary-slam-and-nectin-4-independent-noncytolytic-spread-of-canine-distemper-virus-in-astrocytes
#13
COMMENT
Giovanni Di Guardo, Roberto Giacominelli-Stuffler, Sandro Mazzariol
No abstract text is available yet for this article.
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27989812/lethal-distemper-in-badgers-meles-meles-following-epidemic-in-dogs-and-wolves-evidence-for-viral-adaptation-in-the-wildlife-milieu
#14
Daria Di Sabatino, Gabriella Di Francesco, Guendalina Zaccaria, Daniela Malatesta, Luca Brugnola, Maurilia Marcacci, Ottavio Portanti, Fabrizio De Massis, Giovanni Savini, Liana Teodori, Enzo Ruggieri, Iolanda Mangone, Pietro Badagliacca, Alessio Lorusso
Canine distemper virus (CDV) represents an important conservation threat to many wild carnivores. A large distemper epidemic sustained by an Arctic-lineage strain occurred in Italy in 2013, mainly in the Abruzzi region, causing overt disease in domestic and shepherd dogs, Apennine wolves (Canis lupus) and other wild carnivores. Two badgers were collected by the end of September 2015 in a rural area of the Abruzzi region and were demonstrated to be CDV-positive by real time RT-PCR and IHC in several tissues...
October 27, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27928865/canine-distemper-virus-in-the-serengeti-ecosystem-molecular-adaptation-to-different-carnivore-species
#15
Veljko M Nikolin, Ximena A Olarte-Castillo, Nikolaus Osterrieder, Heribert Hofer, Edward Dubovi, Camila J Mazzoni, Edgar Brunner, Katja V Goller, Robert D Fyumagwa, Patricia D Moehlman, Dagmar Thierer, Marion L East
Was the 1993/1994 fatal canine distemper virus (CDV) epidemic in lions and spotted hyaenas in the Serengeti ecosystem caused by the recent spillover of a virulent domestic dog strain or one well adapted to these noncanids? We examine this question using sequence data from 13 'Serengeti' strains including five complete genomes obtained between 1993 and 2011. Phylogenetic and haplotype network analyses reveal that strains from noncanids during the epidemic were more closely related to each other than to those from domestic or wild canids...
April 2017: Molecular Ecology
https://www.readbyqxmd.com/read/27911942/persistent-morbillivirus-infection-leads-to-altered-cortactin-distribution-in-histiocytic-sarcoma-cells-with-decreased-cellular-migration-capacity
#16
Vanessa Maria Pfankuche, Mohamed Sayed-Ahmed, Vanessa Bono Contioso, Ingo Spitzbarth, Karl Rohn, Reiner Ulrich, Ulrich Deschl, Arno Kalkuhl, Wolfgang Baumgärtner, Christina Puff
Histiocytic sarcomas represent rare but fatal neoplasms in humans. Based on the absence of a commercially available human histiocytic sarcoma cell line the frequently affected dog displays a suitable translational model. Canine distemper virus, closely related to measles virus, is a highly promising candidate for oncolytic virotherapy. Therapeutic failures in patients are mostly associated with tumour invasion and metastasis often induced by misdirected cytoskeletal protein activities. Thus, the impact of persistent canine distemper virus infection on the cytoskeletal protein cortactin, which is frequently overexpressed in human cancers with poor prognosis, was investigated in vitro in a canine histiocytic sarcoma cell line (DH82)...
2016: PloS One
https://www.readbyqxmd.com/read/27902345/advances-in-canine-distemper-virus-pathogenesis-research-a-wildlife-perspective
#17
REVIEW
Angelika K Loots, Emily Mitchell, Desiré L Dalton, Antoinette Kotzé, Estelle H Venter
Canine distemper virus (CDV) has emerged as a significant disease of wildlife, which is highly contagious and readily transmitted between susceptible hosts. Initially described as an infectious disease of domestic dogs, it is now recognized as a global multi-host pathogen, infecting and causing mass mortalities in a wide range of carnivore species. The last decade has seen the effect of numerous CDV outbreaks in various wildlife populations. Prevention of CDV requires a clear understanding of the potential hosts in danger of infection as well as the dynamic pathways CDV uses to gain entry to its host cells and its ability to initiate viral shedding and disease transmission...
March 2017: Journal of General Virology
https://www.readbyqxmd.com/read/27885561/outbreak-of-severe-pseudorabies-virus-infection-in-pig-offal-fed-farmed-mink-in-liaoning-province-china
#18
Hao Liu, Xin-Tong Li, Bo Hu, Xiao-Yu Deng, Lei Zhang, Shi-Zhen Lian, Hai-Ling Zhang, Shuang Lv, Xiang-Hong Xue, Rong-Guang Lu, Ning Shi, Ming-Hao Yan, Peng-Peng Xiao, Xi-Jun Yan
An outbreak of severe pseudorabies virus (PRV) infection in farmed mink occurred in northern China in late 2014, causing significant economic losses in the local fur industry. Here, we report the first case of a PRV outbreak in mink in northeastern China, caused by feeding farmed mink with raw pork or organs contaminated by PRV. Mink infected with virulent PRV exhibited diarrhea, neurologic signs, and higher mortality, which can be misdiagnosed as highly pathogenic mink enteritis virus (MEV), canine distemper virus (CDV), and food poisoning...
March 2017: Archives of Virology
https://www.readbyqxmd.com/read/27876612/lethal-distemper-in-badgers-meles-meles-following-epidemic-in-dogs-and-wolves
#19
Daria Di Sabatino, Gabriella Di Francesco, Guendalina Zaccaria, Daniela Malatesta, Luca Brugnola, Maurilia Marcacci, Ottavio Portanti, Fabrizio De Massis, Giovanni Savini, Liana Teodori, Enzo Ruggieri, Iolanda Mangone, Pietro Badagliacca, Alessio Lorusso
Canine distemper virus (CDV) represents an important conservation threat to many wild carnivores. A large distemper epidemic sustained by an Arctic-lineage strain occurred in Italy in 2013, mainly in the Abruzzi region, causing overt disease in domestic and shepherd dogs, Apennine wolves (Canis lupus) and other wild carnivores. Two badgers were collected by the end of September 2015 in a rural area of the Abruzzi region and were demonstrated to be CDV-positive by real time RT-PCR and IHC in several tissues...
December 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27860224/reduced-angiogenic-gene-expression-in-morbillivirus-triggered-oncolysis-in-a-translational-model-for-histiocytic-sarcoma
#20
Vanessa Maria Pfankuche, Ingo Spitzbarth, Stefanie Lapp, Reiner Ulrich, Ulrich Deschl, Arno Kalkuhl, Wolfgang Baumgärtner, Christina Puff
Histiocytic sarcoma represents a rare malignant tumour with a short survival time, indicating the need of novel treatment strategies including oncolytic virotherapy. The underlying molecular mechanisms of viral oncolysis are largely unknown. As cancer in companion animals shares striking similarities with human counterparts, we chose a permanent canine histiocytic sarcoma cell line (DH82 cells) to identify global transcriptome changes following infection with canine distemper virus (CDV), a paramyxovirus closely related to human measles virus...
April 2017: Journal of Cellular and Molecular Medicine
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