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intraepithelial lesion treatment

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https://www.readbyqxmd.com/read/29771082/-role-of-narrow-band-imaging-in-the-detection-of-malignant-lesions-of-the-oropharynx-and-the-laryngopharynx
#1
J H Wu, X Y Luo
Objective: To explore the role of narrow band imaging (NBI) endoscopy in the diagnosis of oropharyngeal and laryngopharyngeal lesions. Method: NBI and white light (WLI) endoscopy were performed on 90 patients with oropharyngeal and laryngopharyngeal lesions from August 2016 to May 2017. NBI findings were classified into 5 types according to the Ni classification and were compared with histopathological results. Accuracy of NBI on premalignant and malignant lesions were compared with WLI. The connection between NBI findings and phathological results were explored...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770617/the-use-of-conization-to-identify-and-treat-severe-lesions-among-prediagnosed-cin1-and-2-patients-in-japan
#2
Mikio Mikami, Masae Ikeda, Hidetaka Sato, Haruko Iwase, Takayuki Enomoto, Yoichi Kobayashi, Hidetaka Katabuchi
OBJECTIVE: To evaluate the clinical efficiency of identifying patients with suspicious severe lesions by conization among prediagnosed cervical intraepithelial neoplasia (CIN) 1 and 2 patients in Japan. METHODS: The data in a Japanese nation-wide registry for cervical cancer (2009 and 2011) was collected to analyze the clinical efficacy of pre- and postdiagnosis for 13,215 Japanese women who underwent treatment by conization. Their preoperative and postoperative histologic findings and clinical outcomes were evaluated using standard statistical procedures including clinical and demographic characteristics...
March 8, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29762428/outcomes-of-conservative-management-of-high-grade-squamous-intraepithelial-lesions-in-young-women
#3
Marette H Lee, Sarah J Finlayson, Ksenia Gukova, Gillian Hanley, Dianne Miller, Leslie Ann Sadownik
OBJECTIVE: The aim of the study was to determine regression rates of cervical intraepithelial neoplasia (CIN) 2 and 3 in women younger than 24 years, followed conservatively for up to 24 months. MATERIALS AND METHODS: This is a retrospective chart review of colposcopy patients in clinic database based on the following: (1) younger than 24 years at first visit; (2) first visit January 1, 2010, to May 31, 2013, and at least 1 follow-up visit after diagnosis; (3) histologic diagnosis of CIN2+; and (4) optimal conservative management (observation for up to 24 months or to 24 years, whichever occurred first)...
May 4, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29761782/-vulvar-intraepithelial-neoplasia
#4
Signe Østergård, Christina Steen Vorbeck, Mette Meinert
Vulvar intraepithelial neoplasia (VIN) is a rare but premalig-nant condition. VIN has two aetiological pathways: a human papillomavirus (HPV)-dependent pathway, which is a vulvar high-grade squamous intraepithelial lesion (HSIL), and an HPV-independent pathway, called differentiated VIN (d-VIN), associated with lichen sclerosus. d-VIN is more aggressive than vulvar HSIL. In case of symptoms, a biopsy should be performed. The recurrence risk is high: 25-50% regardless of treatment type. We recommend treatment with imiquimod as first choice to avoid mutilating surgery...
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29748382/satellite-rna-increases-dna-damage-and-accelerates-tumor-formation-in-mouse-models-of-pancreatic-cancer
#5
Takahiro Kishikawa, Motoyuki Otsuka, Tatsunori Suzuki, Takahiro Seimiya, Kazuma Sekiba, Rei Ishibashi, Eri Tanaka, Motoko Ohno, Mari Yamagami, Kazuhiko Koike
Highly repetitive tandem arrays such as satellite sequences in the centromeric and pericentromeric regions of chromosomes, which were previously considered to be silent, are actively transcribed in various biological processes, including cancers. In the pancreas, this aberrant expression occurs even in Kras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To determine the biological role of satellite RNAs in carcinogenesis in vivo, we constructed mouse major satellite (MajSAT) RNA-expressing transgenic mice...
May 10, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29747610/the-acceptability-of-high-resolution-anoscopy-examination-in-patients-attending-a-tertiary-referral-centre
#6
Anke De-Masi, Esther Davis, Tamzin Cuming, Noreen Chindawi, Francesca Pesola, Carmelina Cappello, Susan Chambers, Julie Bowring, Adam N Rosenthal, Peter Sasieni, Mayura Nathan
BACKGROUND: High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination and ablative treatment under local anaesthetic. METHODS: Patients took part in anonymised feedback of their experience immediately after their HRA examinations and/or treatments...
May 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29734247/clinical-and-economic-value-of-p16ink4a-for-the-differential-diagnosis-of-morphologic-cervical-intraepithelial-neoplasia-2
#7
Vanina S Fishkel, Fernando C Monge, Felicitas M von Petery, Karen E Tapper, Teresa M Peña, Florencia Torres, Fernando A Poletta, Jorge F Elgart, Alejandra Avagnina, Valeria Denninghoff
The detection of high-grade intraepithelial lesions requires highly sensitive and specific methods that allow more accurate diagnoses. This contributes to a proper management of preneoplastic lesions, thus avoiding overtreatment. The purpose of this study was to analyze the value of immunostaining for p16 in the morphologic assessment of cervical intraepithelial neoplasia 2 lesions, to help differentiate between low-grade (p16-negative) and high-grade (p16-positive) squamous intraepithelial lesions. The direct medical cost of the treatment of cervical intraepithelial neoplasia 2 morphologic lesions was estimated...
May 4, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29725443/calcium-activated-potassium-channels-as-potential-early-markers-of-human-cervical-cancer
#8
Ana Ramírez, Eunice Vera, Armando Gamboa-Domínguez, Paul Lambert, Patricio Gariglio, Javier Camacho
Cervical cancer is a major cause of cancer-associated mortality in women in developing countries. Thus, novel early markers are required. Ion channels have gained great interest as tumor markers, including cervical cancer. The calcium-activated potassium channel KCNMA1 (subunit α-1 from subfamily M) has been associated with different malignancies, including tumors such as breast and ovarian cancer that are influenced by hormones. The KCNMA1 channel blocker iberiotoxin decreases the proliferation of HeLa cervical cancer cells...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29720427/up-regulation-of-inflammation-related-lncrna-il7r-predicts-poor-clinical-outcome-of-patients-with-cervical-cancer
#9
Yangyang Fan, Yan Nan, Juanjuan Huang, Hui Zhong, Weidong Zhou
The long-term chronic inflammation of cervical intraepithelial neoplasia (CIN) induces the initiation and progression of cervical cancer. Long non-coding RNAs (LncRNAs) are being identified to be involved into inflammation and carcinogenesis and could function as cancer biomarkers in clinical. However, the significance of inflammation-related LncRNA (e.g. LncRNA-IL7R) in cervical cancer is limited. We here investigated the clinical role of inflammation-related LncRNA-IL7R (Lnc-IL7R) in healthy cervical tissue (n=15), CIN 1/2/3 (n=35), cervical cancer (n=70), and clarified its function via knockdown in vitro and in vivo The results showed that the expression of Lnc-IL7R was increased from normal tissues to neoplastic lesions and cervical cancer...
May 2, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29704442/factors-affecting-residual-recurrent-cervical-intraepithelial-neoplasia-after-cervical-conization-with-negative-margins
#10
Aiping Fan, Chen Wang, Cha Han, Yingmei Wang, Fengxia Xue, Liqin Zhang
OBJECTIVE: To identify factors for predicting residual or recurrent cervical intraepithelial neoplasia (CIN) after cervical conization with negative margins. METHODS: A total of 172 patients with histologically verified high-grade squamous intraepithelial lesions who underwent conization with negative margins were recruited at the General Hospital of Tianjin Medical University from December 2006 to January 2016. Follow-up comprised clinical examination, liquid-based cytology test, HPV DNA genotyping test, colposcopy assessment, and if indicated, colposcopy-directed punch biopsy...
April 28, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29699549/evaluation-of-human-papillomavirus-testing-and-visual-inspection-for-cervical-cancer-screening-in-rwanda
#11
M Chantal Umulisa, Silvia Franceschi, Iacopo Baussano, Vanessa Tenet, Mathilde Uwimbabazi, Belson Rugwizangoga, Daniëlle A M Heideman, Anne M Uyterlinde, Teresa M Darragh, Peter J F Snijders, Felix Sayinzoga, Gary M Clifford
BACKGROUND: A pilot screening campaign in Rwanda, based on careHPV-testing followed by visual inspection with acetic acid triage (careHPV+VIA triage), was evaluated against other WHO-recommended screening options, namely HPV screen-and-treat and VIA screen-and-treat. METHODS: 764 women aged 30-69 underwent at visit 1: i) VIA, and cervical cell collection for ii) careHPV in Rwanda, and iii) liquid-based cytology and GP5+/6+ HR-HPV PCR in The Netherlands. All 177 women positive by VIA, careHPV and/or PCR were recalled, of whom 84% attended...
April 24, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29690868/oncological-and-reproductive-outcomes-of-adenocarcinoma-in-situ-of-the-cervix-managed-with-the-loop-electrosurgical-excision-procedure
#12
Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin, Zhenyu Zhang
BACKGROUND: The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions. Several previous studies have primarily demonstrated that the loop electrosurgical excision procedure (LEEP) is as safe and effective as cold knife cone (CKC) biopsy when AIS is unexpectedly found in a loop excision. This study evaluated the safety of LEEP as the initial treatment for patients with AIS who were strictly selected and evaluated before and after loop resection...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29652190/anal-cytology-institutional-statistics-correlation-with-histology-and-development-of-multidisciplinary-screening-program-with-review-of-the-current-literature
#13
Elizabeth G Morency, Tracey Harbert, Nazneen Fatima, Julia Samolcyzk, Kruti P Maniar, Ritu Nayar
CONTEXT: - The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. OBJECTIVE: - To review our experience and the current literature to create, in cooperation with clinicians, a standardized screening and treatment algorithm given our large volume of APTs. DATA SOURCES: - All APTs collected between January 2013 and June 2015 were reviewed and correlated with follow-up/concurrent biopsy diagnoses, and clinical and social history...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29627221/fluorescence-microscopy-of-h-e-stained-cervical-biopsies-to-assist-the-diagnosis-and-grading-of-cin
#14
REVIEW
Mario R Castellanos, Vijeyaluxmy Motilal Nehru, Edyta C Pirog, Lynne Optiz
BACKGROUND: Prevention of cervical cancer is based upon the accurate diagnosis and grading of cervical lesions identified during screening. The pathological classification of cervical intraepithelial neoplasia (CIN) is problematic, as it relies on subjective criteria and is known to have high interobserver variability and low reproducibility. These limitations can result in either over or under treatment of patients. Biomarkers to improve CIN diagnosis have not overcome all these challenges...
March 26, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29622059/combined-oral-contraceptives-promote-androgen-receptor-and-oestrogen-receptor-alpha-upregulation-in-the-female-prostate-skene
#15
Eliana G Pinto, Mônica S Campos, Luiz R Falleiros-Júnior, Mara R Marques, Sebastião R Taboga, Carlos H Castro, Manoel F Biancardi, Fernanda C A Santos
The aim of this study was to evaluate the effects of cyproterone acetate (CPA) and ethinyloestradiol (EE) alone or in combination on the female prostate of adult gerbils. Adult females were exposed for 21 days to daily oral doses of CPA (1mgkg-1), EE (10µgkg-1) or a combination of CPA and EE. Female prostatic complexes were removed, weighed and subjected to morphological, stereological, immunohistochemical and ultrastructural analyses. CPA treatment caused epithelial atrophy and decreased prostate secretory activity...
April 6, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29603508/steroidal-hormone-and-morphological-responses-in-the-prostate-anterior-lobe-in-different-cancer-grades-after-celecoxib-and-goniothalamin-treatments-in-tramp-mice
#16
Rafael Sauce Silva, Larissa Akemi Kido, Fabio Montico, Débora Barbosa Vendramini-Costa, Ronaldo Aloise Pilli, Valeria Helena Alves Cagnon
Prostate cancer is the second most diagnosed cancer in the world, and alternative methods to prevent and treat different lesion grades need to be evaluated. The objective was to evaluate the morphological, hormonal and inflammatory responses in the prostate anterior lobe in transgenic adenocarcinoma of the mouse prostate (TRAMP), following Celecoxib and Goniothalamin (GTN) treatments. All animals were treated for 4 weeks, from 8 weeks of age and euthanized either immediately after treatment (12-week-old mice: immediate response) or later (22-week-old mice: late response)...
March 30, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29532409/protein-expression-analysis-in-uterine-cervical-cancer-for-potential-targets-in-treatment
#17
Sugela Blancas, Rogelio Medina-Berlanga, Liliana Ortíz-García, Alfredo Loredo-Ramírez, Leticia Santos
Specific markers in lesions of the human uterine cervix cancer (UCC) are still needed for prognostic, diagnostic and/or therapeutic purposes. In this study we evaluated key molecules at protein level between normal epithelium, cervical intraepithelial neoplasia (CIN1-3) and invasive cancer of a group of molecules previously reported at mRNA level. For that purpose, human formalin-fixed paraffin embedded tissue microarrays (TMAs) were constructed containing 205 Mexican tissue core specimens. Immunohistochemistry and quantitative analysis of histological staining was performed against twenty-two distinct proteins for each core and the processing platform ImageJ...
March 12, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29527150/histological-exhibition-of-the-gastroprotective-effect-of-moringa-oleifera-leaf-extract
#18
S N Ijioma, E N Nwaogazi, A A Nwankwo, H Oshilonya, C M Ekeleme, L U Oshilonya
The gastroprotective activity of Moringa oleifera leaf extract against aspirin-induced ulcers was investigated in rats. Thirty (30) rats under starvation but with access to drinking water for 48 h were divided into 6 groups of 5 animals each. Animals in groups 1 and 2 were pretreated with 0.2 ml normal saline via the oral route. Group 3 received 32 mg/kg cimetidine while those in groups 4, 5 and 6 received oral Moringa leaf extract treatments at doses 200, 400 and 800 mg/kg body weight respectively. Thirty minutes after treatment, all animals in groups 2 to 6 were given 800 mg/kg Aspirin to induce ulcer...
2018: Comparative Clinical Pathology
https://www.readbyqxmd.com/read/29507011/extramammary-paget-s-disease-of-the-scrotum-with-complete-response-to-imiquimod-and-photodynamic-therapy
#19
Tyler M Bauman, Ilana S Rosman, David M Sheinbein
Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm with an extremely variable clinical course. The objective of this study was to determine if combination imiquimod and photodynamic therapy could induce remission of EMPD. A 69-year-old man with EMPD was treated with topical imiquimod 5% cream at night for 5 days per week for 1 month, followed by 2 months of 5% imiquimod for three nights a week. For the following 6 months, monthly 5-aminolevulinic acid photodynamic therapy was added. After 6 months, imiquimod was discontinued and the patient continued to be treated with quarterly photodynamic therapy...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29505679/second-harmonic-imaging-microscopy-for-identifying-colorectal-intraepithelial-neoplasia
#20
L H Li, W Z Jiang, D Y Kang, X Liu, H S Li, G X Guan, S M Zhuo, Z F Chen, J X Chen
In this study, second-harmonic imaging microscopy was used to monitor precancerous colorectal lesions at different stages. It was found that the morphology of glands and lamina propria in mucosa changes with the progression of colorectal diseases from normal to low-grade intraepithelial neoplasia to high-grade intraepithelial neoplasia and this microscopy has the ability of direct visualization of these warning symptoms. Furthermore, two morphologic variables were quantified to determine the changes of glands and collagen in lamina propria during the development of colorectal intraepithelial neoplasia...
March 5, 2018: Journal of Microscopy
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