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intraepithelial lesion treatment

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https://www.readbyqxmd.com/read/28938608/use-of-confocal-laser-endomicroscopy-with-a-fluorescently-labeled-fatty-acid-to-diagnose-colorectal-neoplasms
#1
Feihong Deng, Yuan Fang, Zhiyong Shen, Wei Gong, Tao Liu, Jing Wen, Wanling Zhang, Xianjun Zhu, Hui Zhong, Tong Wang, Fachao Zhi, Biao Nie
Endoscopic treatment for early colorectal cancer closely correlates with patient prognosis. However, endoscopic differentiation between carcinomas and non-neoplastic lesions remains difficult. Here, we topically stained colorectal neoplasms with a fatty acid analogue (BODIPY-FA) and quantified the fluorescent signals using confocal laser endomicroscopy (CLE) and fluorescence microscopy. We also analyzed protein expression in colorectal cancer tissues. We found that expression of fatty acid synthase was elevated, while the expression of fatty acid transporters was reduced in colorectal cancer...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28928886/vulvar-cancer-in-china-epidemiological-features-and-risk-analysis
#2
Xue Xiao, Yi-Bo Meng, Peng Bai, Juan Zou, Ya Zhang, Tri M Bui Nguyen, Jian-Guo Xiao, Xue-Mei Gao, Bang-Fen Wen
Objective: Describe for the first time the clinical, epidemiological features of vulvar cancer in southwest China. Identify risk factors and provide reference for the prevention of vulvar cancer. Method: We retrospectively analyzed 885 patients admitted to the West China Second University Hospital for vulvar diseases between 2006 and 2016. Vulvar cancer patients with previously diagnosed vulvar nonneoplastic epithelial disorders (n=132) were analyzed and compared to those without prior history of vulvar nonneoplastic epithelial disorders (n=219)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28918603/tumor-markers-of-uterine-cervical-cancer-a-new-scenario-to-guide-surgical-practice
#3
REVIEW
Gaetano Valenti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Since the introduction of Pap smear screening, the incidence and mortality of cervical cancer (CC) have been reduced drastically in USA and in other western states. Nevertheless, CC still remains the main cause of death from gynecological cancer in developing countries where screening programs are scant or inexistent. This evidence highlights the efficacy of screening, and the wide use of Human Papilloma Viruses (HPV) vaccines in developed countries. More and more people are, consequentially, undergoing a screening procedure, usually combined with HPV DNA test, increasing the early diagnosis of intraepithelial HPV-related lesions...
September 16, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28902073/cryotherapy-reduces-progression-of-cervical-intraepithelial-neoplasia-grade-1-in-south-african-hiv-infected-women-a-randomized-controlled-trial
#4
Cynthia Firnhaber, Avril Swarts, Bridgette Goeieman, Ntombi Rakhombe, Masangu Mulongo, Anna-Lise Williamson, Pam Michelow, Sibongile Ramotshela, Mark Faesen, Simon Levin, Timothy Wilkin
BACKGROUND: HIV-infected women are at increased risk of cervical cancer, especially in resource-limited countries. Cervical cancer prevention strategies focus treating cervical high-grade squamous intraepithelial lesions (HSIL). The management of low-grade squamous intraepithelial lesions (LSIL) in HIV-infected women is unknown. SETTING: HIV treatment clinic in Johannesburg, South Africa METHODS:: We randomized HIV-infected women with histologic cervical LSIL to cervical cryotherapy vs...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28898279/lifestyle-factors-and-oncogenic-papillomavirus-infection-in-a-high-risk-male-population
#5
Elena Lopez-Diez, Sonia Perez, Manuel Carballo, Amparo Iñarrea, Angel de la Orden, Maximo Castro, Moises Rodríguez, Sheila Almuster, Ruben Montero, Miguel Perez, Jorge Sanchez, Antonio Ojea
BACKGROUND: High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. The study was focused on men with an increased risk of HR-HPV infection: male sexual partners of women diagnosed with high-grade squamous intraepithelial cervical lesions...
2017: PloS One
https://www.readbyqxmd.com/read/28885778/histopathologic-follow-up-and-hpv-test-results-with-hsil-papanicolaou-test-results-in-china-s-largest-academic-women-s-hospital
#6
Xiang Tao, R Marshall Austin, Hao Zhang, Lihong Zhang, Jianan Xiao, Xianrong Zhou, Li Wang, Chengquan Zhao
BACKGROUND: Cervical cancer screening in China is largely limited to occasional opportunistic screening in urban centers. The current study reports histopathologic follow-up and human papillomavirus (HPV) results in women with high-grade squamous intraepithelial lesion (HSIL) Papanicolaou (Pap) tests reported at the largest academic women's hospital in China and compares these findings with those of published Western studies among frequently screened women. METHODS: A retrospective cohort study documented HSIL Pap tests, patient age, HPV results, and histopathologic follow-up from 2011 through 2015 in the Obstetrics and Gynecology Hospital of Fudan University (OGHFU) in Shanghai, China...
September 8, 2017: Cancer
https://www.readbyqxmd.com/read/28877935/targeting-aberrant-p70s6k-activation-for-estrogen-receptor-negative-breast-cancer-prevention
#7
Xiao Wang, Jun Yao, Jinyang Wang, Qingling Zhang, Samuel Warren Brady, Banu Arun, Victoria Seewaldt, Dihua Yu
The prevention of ER- breast cancer remains a major challenge in the cancer prevention field although anti-estrogen and aromatase inhibitors have shown adequate efficacy in preventing ER+ breast cancer. Lack of commonly expressed, druggable targets is a major obstacle for meeting this challenge. Previously, we detected the activation of Akt signaling pathway in atypical hyperplasic early stage lesions of patients. In the current study, we found that Akt and the downstream p70S6K signaling pathway was highly activated in ER- pre-malignant breast lesions and ER- breast cancer...
September 6, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28857936/radiofrequency-ablation-therapy-for-anal-intraepithelial-neoplasia-results-from-a-single-center-prospective-pilot-study-in-hiv-participants
#8
Robert N Goldstone, Shirin R Hasan, Stephen E Goldstone
BACKGROUND: HIV-positive individuals have high incidence of anal high-grade squamous intraepithelial lesions (HSIL) at the squamocolumnar junction (SCJ), which can progress to cancer.1 Focal radiofrequency ablation (RFA) treats HSIL, but metachronous recurrence remains high and may be improved with circumferential treatment. SETTING: The study was performed at a single center. METHODS: This was a prospective trial of circumferential anal RFA using Barrx™ 60 RFA focal catheters in participants with ≥1 anal SCJ HSIL...
August 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28833949/argon-plasma-coagulation-treatment-of-anal-high-grade-squamous-intraepithelial-lesions-in-men-who-have-sex-with-men-living-with-hiv-results-of-a-2-year-prospective-pilot-study
#9
A de Pokomandy, D Rouleau, R Lalonde, C Beauvais, C de Castro, F Coutlée
OBJECTIVES: Men who have sex with men (MSM) living with HIV are at high risk for anal high-grade squamous intraepithelial lesions (HSILs) and cancer. The best management of anal HSIL remains unclear. Our objective was to assess whether argon plasma coagulation (APC) could be safe, well tolerated and efficient to treat anal HSILs in MSM living with HIV. METHODS: A prospective phase II, open-label, pilot study was conducted to evaluate APC to treat anal HSILs in 20 HIV-positive MSM...
August 23, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28832077/diagnostic-and-treatment-reproducibility-of-cervical-intraepithelial-neoplasia-squamous-intraepithelial-lesion-and-factors-affecting-the-diagnosis
#10
Arzu Sağlam, Alp Usubütün, Anıl Dolgun, George L Mutter, M Coşkun Salman, Olcay Kurtulan, Aytekin Akyol, Eylem Akar Özkan, Sema Baykara, Dilek Bülbül, Zerrin Calay, Funda Eren, Derya Gümürdülü, Nihan Haberal, Şennur Ilvan, Şeyda Karaveli, Meral Koyuncuoğlu, Bahar Müezzinoğlu, Kamil Hakan Müftüoğlu, Özlem Özen, Necmettin Özdemir, Elif Peştereli, Çağnur Ulukuş, Osman Zekioğlu
OBJECTIVE: Inter-observer differences in the diagnosis of HPV related cervical lesions are problematic and response of gynecologists to these diagnostic entities is non-standardized. This study evaluated the diagnostic reproducibility of "cervical intraepithelial neoplasia" (CIN) and "squamous intraepithelial lesion" (SIL) diagnoses. MATERIAL AND METHOD: 19 pathologists evaluated 66 cases once using H&E slides and once with immunohistochemical studies (p16, Ki-67 and Pro-ExC)...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28831506/-cystic-pancreatic-tumors-diagnostics-and-new-biomarkers
#11
REVIEW
A W Berger, T Seufferlein, A Kleger
Mortality due to pancreatic ductal adenocarcinoma (PDAC) will increase in the near future. The only curative treatment for PDAC is radical resection; however, even small carcinomas exhibit micrometastases leading to early relapse. Accordingly, detection of premalignant precursor lesions is important. In essence, PDAC develops from three precursor lesions: pancreatic intraepithelial lesions (PanIN), intraductal papillary-mucinous neoplasia (IPMN) and mucinous-cystic neoplasia (MCN). Together with serous cystic neoplasia (SCN) and solid pseudopapillary neoplasia (SPN), these cystic lesions constitute the most common cystic neoplasms in the pancreas...
August 22, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28828409/the-diagnostic-accuracy-of-conventional-forceps-biopsy-compared-to-esd
#12
Shimin Wu, Xinjian Zhu, Lijuan Xiang, Jianqiang Chen, Chunxiao Chen
OBJECTIVE: conventional forceps biopsy (CFB) is the most popular way to screen for gastric epithelial neoplasia (GEN). Our study aimed to compare the diagnostic accuracy between conventional forceps biopsy and endoscopic submucosal dissection (ESD). METHODS: 105 patients diagnosed GEN finally undertook ESD in our hospital were enrolled. We retrospectively assessed the characteristics of pathological results of CFB and ESD. RESULTS: The overall pathologic concordance rate between the CFB and ESD specimens was 68...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28807605/adjuvant-hpv-vaccination-for-anal-cancer-prevention-in-hiv-positive-men-who-have-sex-with-men-the-time-is-now
#13
Ashish A Deshmukh, Scott B Cantor, Elisabeth Fenwick, Elizabeth Y Chiao, Alan G Nyitray, Elizabeth A Stier, Stephen E Goldstone, Timothy Wilkin, Jagpreet Chhatwal
IMPORTANCE: Outcomes of treating high-grade squamous intraepithelial lesions (HSIL), a precursor to anal cancer, remain uncertain. Emerging evidence shows that post HSIL treatment adjuvant quadrivalent human papillomavirus (qHPV) vaccination improves the effectiveness of treatment. However, no recommendations exist regarding the use of qHPV vaccine as an adjuvant form of therapy. Our objective was to determine whether post-treatment adjuvant vaccination should be adopted in HIV-infected MSM (individuals at highest risk for anal cancer) on the basis of cost-effectiveness determined using existing evidence or whether future research is needed...
September 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28796882/cytology-versus-hpv-testing-for-cervical-cancer-screening-in-the-general-population
#14
REVIEW
George Koliopoulos, Victoria N Nyaga, Nancy Santesso, Andrew Bryant, Pierre Pl Martin-Hirsch, Reem A Mustafa, Holger Schünemann, Evangelos Paraskevaidis, Marc Arbyn
BACKGROUND: Cervical cancer screening has traditionally been based on cervical cytology. Given the aetiological relationship between human papillomavirus (HPV) infection and cervical carcinogenesis, HPV testing has been proposed as an alternative screening test. OBJECTIVES: To determine the diagnostic accuracy of HPV testing for detecting histologically confirmed cervical intraepithelial neoplasias (CIN) of grade 2 or worse (CIN 2+), including adenocarcinoma in situ, in women participating in primary cervical cancer screening; and how it compares to the accuracy of cytological testing (liquid-based and conventional) at various thresholds...
August 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28780541/associations-between-highly-active-antiretroviral-therapy-and-the-presence-of-hpv-premalignant-and-malignant-cervical-lesions-in-sub-saharan-africa-a-systematic-review-current-evidence-and-directions-for-future-research
#15
Sonia Menon, Rodolfo Rossi, Natasha Zdraveska, Mbabazi Kariisa, Sushama D Acharya, Davy Vanden Broeck, Steven Callens
OBJECTIVES: In sub-Saharan Africa, substantial international funding along with evidence-based clinical practice have resulted in an unparalleled scale-up of access to antiretroviral treatment at a higher CD4 count. The role and timing of highly active antiretroviral therapy (HAART) in mediating cervical disease remains unclear. The aim of this article is to systematically review all evidence pertaining to Africa and identify research gaps regarding the epidemiological association between HAART use and the presence of premalignant/malignant cervical lesions...
August 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28767389/use-of-confocal-laser-endomicroscopy-with-a-fluorescently-labeled-fatty-acid-to-diagnose-colorectal-neoplasms
#16
Feihong Deng, Yuan Fang, Zhiyong Shen, Wei Gong, Tao Liu, Jing Wen, Wanling Zhang, Xianjun Zhu, Hui Zhong, Tong Wang, Fachao Zhi, Biao Nie
Endoscopic treatment for early colorectal cancer closely correlates with patient prognosis. However, endoscopic differentiation between carcinomas and non-neoplastic lesions remains difficult. Here, we topically stained colorectal neoplasms with a fatty acid analogue (BODIPY-FA) and quantified the fluorescent signals using confocal laser endomicroscopy (CLE) and fluorescence microscopy. We also analyzed protein expression in colorectal cancer tissues. We found that expression of fatty acid synthase was elevated, while the expression of fatty acid transporters was reduced in colorectal cancer...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765837/the-impact-of-finasteride-and-dutasteride-treatments-on-proliferation-apoptosis-androgen-receptor-5%C3%AE-reductase-1-and-5%C3%AE-reductase-2-in-tramp-mouse-prostates
#17
Alexander B Opoku-Acheampong, Jamie N Henningson, Brian L Lindshield
BACKGROUND: Previously, we studied the effect of finasteride- or dutasteride-containing diets in male C57BL/6 TRAMP x FVB mice. Pre (6 weeks of age) and post (12 weeks of age) groups received finasteride or dutasteride to determine the efficacy of these pharmaceuticals on prostate cancer (PCa) development in male C57BL/6 TRAMP x FVB mice. Post-Dutasteride treatment was more effective than Pre-Dutasteride treatment, and dutasteride treatments were more effective than finasteride treatments in decreasing prostatic intraepithelial neoplasia (PIN) progression and PCa development...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28765154/gemcitabine-induced-timp1-attenuates-therapy-response-and-promotes-tumor-growth-and-liver-metastasis-in-pancreatic-cancer
#18
Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y Lim, Ana L Gomes, Paul Kinchesh, Sean C Smart, W Gillies McKenna, Francesca M Buffa, Owen J Sansom, Ruth J Muschel, Eric O'Neill, Emmanouil Fokas
Gemcitabine constitutes one of the backbones for chemotherapy treatment in pancreatic ductal adenocarcinoma (PDAC), but patients often respond poorly to this agent. Molecular markers downstream of gemcitabine treatment in pre-clinical models may provide an insight into resistance mechanisms. Using cytokine arrays, we identified potential secretory biomarkers of gemcitabine resistance (response) in the transgenic KRasG12D; Trp53R172H; Pdx-1 Cre (KPC) mouse model of PDAC. We verified the oncogenic role of the cytokine tissue inhibitor of matrix metalloproteinases 1 (TIMP1) in primary pancreatic tumors and metastases using both in vitro techniques and animal models...
August 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28763913/-analysis-of-psychological-status-and-relevant-factors-of-patients-with-esophageal-and-gastric-cardia-precancerous-lesions-in-linzhou-of-henan
#19
S R Ma, Q Ma, C Q Hao, C T Guan, B Y Li, J W Wang, X Q Li, Z K Liu, W W Wei
Objective: To explore the psychological status and related factors in patients with precancerous of esophageal and gastric cardia in Linzhou of Henan. Methods: Clinical psycho-rating scale of Social Support Rating Scale (SSRS), Self-Rating Anxiety Scale (SAS, score ≥50 points with symptoms of anxiety) and Self-Rating Depression Scale (SDS, score ≥53 points with the symptoms of depression) were applied to survey life events and psychological status of subjects who aged 40-69 years old and participated in"The Early diagnosis and Early Treatment"program in Linzhou cancer hospital from July 2015 to Jan 2016...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28753702/probe-based-endomicroscopy-for-in-vivo-detection-of-gastric-intestinal-metaplasia-and-neoplasia-a-multicenter-randomized-controlled-trial
#20
Xiu-Li Zuo, Zhen Li, Chang-Qing Li, You-You Zheng, Li-Dong Xu, Jie Chen, Rong Lin, Jun Song, Chao-Hui Yu, Min Yue, Qi Zhou, Zhi-Yan Liu, Yan-Qing Li
Background and study aims Owing to the indistinctive endoscopic appearance of gastric intestinal metaplasia (GIM), gastric intraepithelial neoplasia (GIN), and early gastric cancer (EGC), a significant number of such lesions may be missed during surveillance endoscopy. The aim of this clinical trial was to assess the value of combined computed virtual chromoendoscopy (flexible spectral imaging color enhancement [FICE]) and probe-based confocal laser endomicroscopy (pCLE) for in vivo detection of GIM, GIN, and EGC...
July 28, 2017: Endoscopy
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