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Cancer-related Fatigue

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https://www.readbyqxmd.com/read/29933034/cdk4-6-inhibitors-in-breast-cancer-therapy-current-practice-and-future-opportunities
#1
REVIEW
Filipa Lynce, Ayesha N Shajahan-Haq, Sandra M Swain
Dysregulation of the cyclin dependent kinase pathway in luminal breast cancer creates a new therapeutic opportunity for estrogen receptor positive breast cancer. Initial pan-CDK inhibitors were associated with extensive toxicities but in recent years, the development of potent specific CDK inhibitors with favorable tolerability has driven renewed interests in this class of targeted therapies. Palbociclib, ribociclib and abemaciclib are specific CDK4/6 inhibitors that have been approved by the U.S. Food and Drug Administration for use in combination with endocrine therapy for women with advanced hormone receptor positive breast cancer...
June 19, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29930550/neuroimmunology-of-behavioral-comorbidities-associated-with-cancer-and-cancer-treatments
#2
REVIEW
Jessica C Santos, Leah M Pyter
Behavioral comorbidities (depression, anxiety, fatigue, cognitive disturbances, and neuropathic pain) are prevalent in cancer patients and survivors. These mental and neurological health issues reduce quality-of-life, which is a significant societal concern given the increasing rates of long-term survival after various cancers. Hypothesized causes of behavioral comorbidities with cancer include tumor biology, stress associated with the cancer experience, and cancer treatments. A relatively recent leading mechanism by which these causes contribute to changes in neurobiology that underlie behavior is inflammation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29929087/an-effort-expenditure-perspective-on-cancer-related-fatigue
#3
Tamara E Lacourt, Elisabeth G Vichaya, Carmen Escalante, Ellen F Manzullo, Brandon Gunn, Kenneth R Hess, Cobi J Heijnen, Robert Dantzer
While fatigue is the most common and debilitating side effect of cancer and cancer treatment it is still poorly understood, partly because it is usually characterized by patient-reported outcomes. As patient-reports are inherently subjective, behavioral correlates of the symptom of fatigue are needed to increase our understanding of the symptom. We focused on motivational effort expenditure as a crucial behavior in cancer-related fatigue, using a validated computerized task contrasting high effort/high reward and low effort/low reward choices under different probabilities of success...
June 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29926131/a-phase-i-study-of-ly3164530-a-bispecific-antibody-targeting-met-and-egfr-in-patients-with-advanced-or-metastatic-cancer
#4
Amita Patnaik, Michael Gordon, Frank Tsai, Kyri Papadopoulous, Drew Rasco, S Muralidhar Beeram, Siqing Fu, Filip Janku, Scott M Hynes, Sushma R Gundala, Melinda D Willard, Wei Zhang, Aimee Bence Lin, David Hong
PURPOSE: The phase I study characterized the safety, pharmacokinetics, anti-tumor activity, and recommended phase II dose/schedule of LY3164530 in patients with advanced or metastatic cancer. METHODS: Patients received LY3164530 on days 1 and 15 (Schedule 1: 300, 600, 1000, and 1250 mg) or Days 1, 8, 15, and 22 (Schedule 2: 500 and 600 mg) of each 28 days cycle. Dose escalation used a modified toxicity probability interval model. RESULTS: Dose escalation defined a maximum tolerated dose (MTD) of 1000 mg on Schedule 1 and 500 mg on Schedule 2...
June 20, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29925044/a-systematic-review-of-patient-reported-outcomes-in-phase-ii-or-iii-clinical-trials-of-myelodysplastic-syndromes-and-acute-myeloid-leukemia
#5
REVIEW
Ashley Leak Bryant, Sarah W Drier, Sejin Lee, Antonia V Bennett
The purpose of this systematic literature review was to identify clinical trials of MDS and AML that included patient-reported outcome (PRO) instruments, and to summarize the symptom and other health related quality of life (HRQOL) concepts most frequently assessed and the PRO instruments that were used. Sixteen manuscripts describing 14 distinct trials met all criteria (i.e., phase 2 or 3 clinical trial for MDS or AML which included PRO assessment) and were published between 1996-2017. In trials evaluating anemia, PRO scores showed significant improvement in relevant domains (e...
June 7, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29924668/effect-of-fitbit-and-ipad-wearable-technology-in-health-related-quality-of-life-in-adolescent-and-young-adult-cancer-patients
#6
Ilana R Yurkiewicz, Pamela Simon, Michaela Liedtke, Gary Dahl, Tamara Dunn
PURPOSE: Adolescent and young adult (AYA) patients with cancer face significant challenges with regard to fatigue, reduced physical activity, and social isolation, which may negatively impact quality of life. This study investigated whether the use of digital wearable technology (Fitbits, along with synced iPads) can affect health-related quality of life (HRQOL) in AYA aged patients with cancer. MATERIALS AND METHODS: This was a prospective cohort study that offered Fitbits and iPads to all AYA patients aged 15 to 29 at an academic medical center at the time of cancer diagnosis...
June 20, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29922633/kamikihito-improves-cancer-related-fatigue-by-restoring-balance-between-the-sympathetic-and-parasympathetic-nervous-systems
#7
Satoshi Tamada, Kyoko Ebisu, Sayaka Yasuda, Minoru Kato, Noriko Ninomiya, Takeshi Yamasaki, Taro Iguchi, Tatsuya Nakatani, Yasuyoshi Watanabe
Background: Cancer-related fatigue is one of the most prevalent symptoms that patients with cancer experience, but the mechanisms underlying it are unknown. We aimed to quantify and mechanistically evaluate the improvement in fatigue related to administration of the Kampo medicine, Kamikihito. Materials and methods: Initially, we recruited outpatients with urological diseases and compared fatigue levels of 37 patients with cancer with a control group of 23 volunteers who had recovered completely from cancer or who were being treated for dysuria...
June 2018: Prostate International
https://www.readbyqxmd.com/read/29921320/phase-ia-study-of-the-indoleamine-2-3-dioxygenase-1-ido1-inhibitor-navoximod-gdc-0919-in-patients-with-recurrent-advanced-solid-tumors
#8
Asha Nayak-Kapoor, Zhonglin Hao, Ramses Sadek, Robin Dobbins, Lisa Marshall, Nicholas N Vahanian, W Jay Ramsey, Eugene Kennedy, Mario R Mautino, Charles J Link, Ray S Lin, Stephanie Royer-Joo, Xiaorong Liang, Laurent Salphati, Kari M Morrissey, Sami Mahrus, Bruce McCall, Andrea Pirzkall, David H Munn, John E Janik, Samir N Khleif
BACKGROUND: Indoleamine-2,3-dioxygenase 1 (IDO1) catalyzes the oxidation of tryptophan into kynurenine and is partially responsible for acquired immune tolerance associated with cancer. The IDO1 small molecule inhibitor navoximod (GDC-0919, NLG-919) is active as a combination therapy in multiple tumor models. METHODS: This open-label Phase Ia study assessed safety, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of navoximod in patients with recurrent/advanced solid tumors, administered as 50-800 mg BID on a 21/28 day and at 600 mg on a 28/28 day schedule...
June 20, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29920845/work-specific-cognitive-symptoms-and-the-role-of-work-characteristics-fatigue-and-depressive-symptoms-in-cancer-patients-during-18-months-post-return-to-work
#9
H F Dorland, F I Abma, C A M Roelen, R Stewart, B C Amick, U Bültmann, A V Ranchor
OBJECTIVE: Cancer patients can experience work-specific cognitive symptoms post return to work (RTW). The study aims to: 1) describe the course of work-specific cognitive symptoms in the first 18 months post RTW, and 2) examine the associations of work characteristics, fatigue and depressive symptoms with work-specific cognitive symptoms over time. METHODS: This study used data from the 18-months longitudinal "Work Life after Cancer" cohort. The Cognitive Symptom Checklist-Work, Dutch Version (CSC-W DV) was used to measure work-specific cognitive symptoms...
June 19, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29915949/dietary-supplements-and-fatigue-in-patients-with-breast-cancer-a-systematic-review
#10
REVIEW
Paula Tâmara Vieira Teixeira Pereira, Andréa Dias Reis, Renata Rodrigues Diniz, Franciléia Andrade Lima, Richard Diego Leite, Mayara Cristina Pinto da Silva, Rosane Nassar Meireles Guerra, Érica Brandão de Moraes Vieira, João Batista Santos Garcia
PURPOSE: Cancer-related fatigue (CRF) is defined as a distressing, persistent, and subjective sense of physical or emotional and/or cognitive exhaustion. The treatment of CRF includes pharmacological and non-pharmacological therapies; dietary strategies with promising results have also been used. This study aimed to identify dietary supplements that improve fatigue in patients with breast cancer. METHODS: A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29915446/refractory-hypotension-due-to-nivolumab-induced-adrenal-insufficiency
#11
Yoshiaki Tsukizawa, Keisuke Kondo, Toshihisa Ichiba, Hiroshi Naito, Kazuhito Mizuki, Ken Masuda
Nivolumab, a new immune checkpoint inhibitor that has been found to improve outcomes for patients with some advanced cancers, is being increasingly used. Immune checkpoint inhibitors can cause immune-related adverse events, including dermatitis, enterocolitis, hepatitis and hypophysitis, but adrenal insufficiency rarely occurs. We present a case of Nivolumab-induced adrenal insufficiency in a man who complained of refractory hypotension. A 52-year-old man with non-small cell lung cancer visited our emergency department complaining of fatigue and diarrhea...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29914528/how-to-address-the-challenges-of-evaluating-treatment-benefits-risks-in-rare-diseases-a-convergent-mixed-methods-approach-applied-within-a-merkel-cell-carcinoma-phase-2-clinical-trial
#12
Murtuza Bharmal, Isabelle Guillemin, Alexia Marrel, Benoit Arnould, Jérémy Lambert, Meliessa Hennessy, Fatoumata Fofana
BACKGROUND: Demonstrating treatment benefits within clinical trials in the context of rare diseases is often methodologically and practically challenging. Mixed methods research offers an approach to overcome these challenges by combining quantitative and qualitative data, thus providing a better understanding of the research question. A convergent mixed methods design in the context of Merkel cell carcinoma, a rare skin cancer, was used during the JAVELIN Merkel 200 trial (NCT02155647)...
June 18, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29914509/a-prospective-observational-study-to-assess-clinical-decision-making-prognosis-quality-of-life-and-satisfaction-with-care-in-patients-with-relapsed-refractory-multiple-myeloma-the-clarity-study-protocol
#13
Fabio Efficace, Mario Boccadoro, Antonio Palumbo, Maria Teresa Petrucci, Francesco Cottone, Laura Cannella, Elena Zamagni, Pasquale Niscola, Charalampia Kyriakou, Tommaso Caravita, Massimo Offidani, Franco Mandelli, Michele Cavo
BACKGROUND: Treatment decision-making in patients with relapsed/refractory multiple myeloma (RRMM) is challenging for a number of reasons including, the heterogeneity of disease at relapse and the number of possible therapeutic approaches. This study broadly aims to generate new evidence-based data to facilitate clinical decision-making in RRMM patients. The primary objective is to investigate the prognostic value of patient self-reported fatigue severity for overall survival. METHODS: This multicenter prospective observational study will consecutively enroll 312 patients with multiple myeloma who have received at least 1 prior line of therapy and are considered as RRMM according to the International Myeloma Working Group (IMWG) criteria...
June 18, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29912607/reference-data-of-the-eortc-qlq-c30-questionnaire-five-consecutive-annual-assessments-of-approximately-2000-representative-dutch-men-and-women
#14
Floortje Mols, Olga Husson, Marije Oudejans, Carla Vlooswijk, Nicole Horevoorts, Lonneke V van de Poll-Franse
OBJECTIVE: Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire. METHODS: The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333)...
June 18, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29910314/cancer-and-exercise-warburg-hypothesis-tumour-metabolism-and-high-intensity-anaerobic-exercise
#15
REVIEW
Peter Hofmann
There is ample evidence that regular moderate to vigorous aerobic physical activity is related to a reduced risk for various forms of cancer to suggest a causal relationship. Exercise is associated with positive changes in fitness, body composition, and physical functioning as well as in patient-reported outcomes such as fatigue, sleep quality, or health-related quality of life. Emerging evidence indicates that exercise may also be directly linked to the control of tumour biology through direct effects on tumour-intrinsic factors...
January 31, 2018: Sports
https://www.readbyqxmd.com/read/29909057/study-design-and-protocol-for-a-culturally-adapted-cognitive-behavioral-stress-and-self-management-intervention-for-localized-prostate-cancer-the-encuentros-de-salud-study
#16
Frank J Penedo, Michael H Antoni, Patricia I Moreno, Lara Traeger, Dolores Perdomo, Jason Dahn, Gregory E Miller, Steve Cole, Julian Orjuela, Edgar Pizarro, Betina Yanez
Almost 2.8 million men in the U.S. are living with prostate cancer (PC), accounting for 40% of all male cancer survivors. Men diagnosed with prostate cancer may experience chronic and debilitating treatment side effects, including sexual and urinary dysfunction, pain and fatigue. Side effects can be stressful and can also lead to poor psychosocial functioning. Prior trials reveal that group-based cognitive behavioral stress and self-management (CBSM) is effective in reducing stress and mitigating some of these symptoms, yet little is known about the effects of culturally-translated CBSM among Spanish-speaking men with PC...
June 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29908324/pd-1-blockade-with-nivolumab-in-patients-with-recurrent-malignant-pleural-mesothelioma
#17
Josine Quispel-Janssen, Vincent van der Noort, Jeltje F de Vries, Marion Zimmerman, Ferry Lalezari, Erik Thunnissen, Kim Monkhorst, Robert Schouten, Laurel Schunselaar, Maria Disselhorst, Houke Klomp, Koen Hartemink, Sjaak Burgers, Wieneke Buikhuisen, Paul Baas
BACKGROUND: Malignant Pleural Mesothelioma (MPM) has limited treatment options and a poor outcome. PD-1/PD-L1 checkpoint inhibitors have proven efficacious in several cancer types. Nivolumab is a fully humanized monoclonal antibody against PD-1 with a favorable toxicity profile. In MPM, the immune system is considered to play an important role. We therefore tested nivolumab in recurrent MPM. METHODS: In this single center trial, patients with MPM received nivolumab 3mg/kg i...
June 13, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29905941/life-stress-as-a-risk-factor-for-sustained-anxiety-and-cortisol-dysregulation-during-the-first-year-of-survivorship-in-ovarian-cancer
#18
Jessica S Armer, Lauren Clevenger, Lauren Z Davis, Michaela Cuneo, Premal H Thaker, Michael J Goodheart, David P Bender, Laila Dahmoush, Anil K Sood, Steven W Cole, George M Slavich, Susan K Lutgendorf
BACKGROUND: Patients with ovarian cancer often report elevated anxiety at diagnosis that decreases posttreatment. However, a minority of patients experience sustained anxiety. Few studies have examined risk factors for persistent anxiety or its physiologic sequelae in ovarian cancer. Therefore, the authors investigated associations between prior life events, anxiety, inflammation (plasma levels of interleukin-6), and diurnal cortisol profiles in patients with ovarian cancer during the first year postdiagnosis...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29905018/phase-ii-study-of-carboplatin-pemetrexed-and-bevacizumab-in-advanced-nonsquamous-non-small-cell-lung-cancer
#19
Nicole F Laslett, SuJung Park, Gregory A Masters, David D Biggs, Charles J Schneider, Jamal G Misleh, Kathir Suppiah, Pamela S Simpson, Stephen Grubbs, Timothy F Wozniak, Michael Guarino
Lung cancer remains the leading cause of cancer death throughout the world. Despite new chemotherapeutic, immunomodulating and molecularly targeted agents, patients with locally advanced or metastatic disease still have a poor prognosis. This trial looked to combine antiangiogenic therapy with a first-line cytotoxic chemotherapy doublet, hoping to extend median progression-free survival (PFS) while minimizing toxicity in patients with advanced nonsquamous non-small-cell lung cancer (NSCLC). In this single institution, single-arm study, 51 patients (age >18 yo) were followed from 2007 to 2012...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29903802/study-protocol-for-a-feasibility-study-of-an-internet-administered-guided-cbt-based-self-help-intervention-engage-for-parents-of-children-previously-treated-for-cancer
#20
Joanne Woodford, Anna Wikman, Martin Cernvall, Gustaf Ljungman, Amanda Romppala, Helena Grönqvist, Louise von Essen
INTRODUCTION: A subgroup of parents of children previously treated for cancer report long-term psychological distress after end of treatment. However, needs for psychological support are commonly unmet and there is a lack of evidence-based treatments tailored to the specific needs of this population. An internet-administered, guided, cognitive-behavioural therapy-based, self-help intervention (ENGAGE) for parents of children previously treated for cancer may provide a solution. The aim is to examine the feasibility and acceptability of the intervention ENGAGE and the study procedures for a future controlled trial...
June 14, 2018: BMJ Open
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