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Cancer-related Fatigue

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https://www.readbyqxmd.com/read/29451666/pilates-for-breast-cancer-a-systematic-review-and-meta-analysis
#1
Roberta Costa Espíndula, Gabriella Barbosa Nadas, Maria Inês da Rosa, Charlie Foster, Florentino Cardoso de Araújo, Antonio Jose Grande
INTRODUCTION: Breast cancer is the leading type of cancer causing death in women worldwide. The incidence of the disease is expected to grow worldwide due to the aging of the population and risk factors related to lifestyle behaviors. Considering the lifestyle of women with breast cancer before or after surgery, pilates exercise may be a complementary intervention additionally to standard treatment. OBJECTIVE: To analyze the efficacy of pilates compared to other exercises and to no exercise for women with breast cancer diagnosis...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29445285/the-effect-of-exercise-on-cancer-related-fatigue-in-cancer-survivors-a-systematic-review-and-meta-analysis
#2
REVIEW
Ellen Kessels, Olga Husson, Christina M van der Feltz-Cornelis
Objective: The objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls. Methods: Trials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29440804/prevalence-and-severity-of-sleep-disturbances-among-patients-with-early-breast-cancer
#3
Rami Fakih, Mahmoud Rahal, Lara Hilal, Lana Hamieh, Mohammed Dany, Simone Karam, Latifa Shehab, Nagi S El Saghir, Arafat Tfayli, Ziad Salem, Hazem Assi, Sally Temraz, Ali Shamseddine, Deborah Mukherji
Context: Data regarding health-related quality of life in breast cancer patients in the Middle East are limited with fatigue and sleep disturbance being the most distressing symptoms reported by patients treated for early breast cancer. Aims: The aim of this study was to examine the prevalence and incidence of insomnia among patients with early-stage breast cancer patients treated with chemotherapy. Subjects and Methods: This was a prospective cohort study...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29440181/a-first-in-human-study-of-the-new-oral-selective-estrogen-receptor-degrader-azd9496-for-hr-her2-advanced-breast-cancer
#4
Erika P Hamilton, Manish R Patel, Anne C Armstrong, Richard D Baird, Komal Jhaveri, Matthias Hoch, Teresa Klinowska, Justin P O Lindemann, Shethah Morgan, Gaia Schiavon, Hazel M Weir, Seock-Ah Im
PURPOSE: AZD9496 is an oral non-steroidal, small-molecule inhibitor of estrogen receptor alpha (ERα), and a potent and selective antagonist and degrader of ERα. This first in human Phase 1 study determined the safety and tolerability of ascending doses of oral AZD9496 in women with estrogen receptor (ER)+/HER2- advanced breast cancer, characterized its pharmacokinetic (PK) profile, and made preliminary assessment of antitumor activity. EXPERIMENTAL DESIGN: Forty-five patients received AZD9496 (20 mg once daily to 600 mg twice daily) in a dose-escalation, dose- expansion 'rolling 6' design...
February 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29439857/axitinib-in-combination-with-pembrolizumab-in-patients-with-advanced-renal-cell-cancer-a-non-randomised-open-label-dose-finding-and-dose-expansion-phase-1b-trial
#5
Michael B Atkins, Elizabeth R Plimack, Igor Puzanov, Mayer N Fishman, David F McDermott, Daniel C Cho, Ulka Vaishampayan, Saby George, Thomas E Olencki, Jamal C Tarazi, Brad Rosbrook, Kathrine C Fernandez, Mariajose Lechuga, Toni K Choueiri
BACKGROUND: Previous studies combining PD-1 checkpoint inhibitors with tyrosine kinase inhibitors of the VEGF pathway have been characterised by excess toxicity, precluding further development. We hypothesised that axitinib, a more selective VEGF inhibitor than others previously tested, could be combined safely with pembrolizumab (anti-PD-1) and yield antitumour activity in patients with treatment-naive advanced renal cell carcinoma. METHODS: In this ongoing, open-label, phase 1b study, which was done at ten centres in the USA, we enrolled patients aged 18 years or older who had advanced renal cell carcinoma (predominantly clear cell subtype) with their primary tumour resected, and at least one measureable lesion, Eastern Cooperative Oncology Group performance status 0-1, controlled hypertension, and no previous systemic therapy for renal cell carcinoma...
February 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29433963/pertuzumab-and-trastuzumab-with-or-without-metronomic-chemotherapy-for-older-patients-with-her2-positive-metastatic-breast-cancer-eortc-75111-10114-an-open-label-randomised-phase-2-trial-from-the-elderly-task-force-breast-cancer-group
#6
Hans Wildiers, Konstantinos Tryfonidis, Lissandra Dal Lago, Peter Vuylsteke, Giuseppe Curigliano, Simon Waters, Barbara Brouwers, Sevilay Altintas, Nathan Touati, Fatima Cardoso, Etienne Brain
BACKGROUND: Despite the high incidence of metastatic breast cancer and its related mortality in the elderly population, our knowledge about optimal treatment for older patients with cancer is far from adequate. We aimed to evaluate the efficacy of dual anti-HER2 treatment with or without metronomic chemotherapy in older patients with HER2-positive metastatic breast cancer. METHODS: We did a multicentre, open-label, randomised, phase 2 trial in 30 centres from eight countries in Europe, in patients with histologically proven, HER2-positive metastatic breast cancer, without previous chemotherapy for metastatic disease, who were 70 years or older, or 60 years or older with confirmed functional restrictions defined by protocol, and had a life expectancy of more than 12 weeks and a performance status according to WHO scale of 0-3...
February 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29429612/the-effect-of-lenalidomide-on-health-related-quality-of-life-in-patients-with-lower-risk-non-del-5q-myelodysplastic-syndromes-results-from-the-mds-005-study
#7
Valeria Santini, Antonio Almeida, Aristoteles Giagounidis, Uwe Platzbecker, Rena Buckstein, C L Beach, Shien Guo, Arman Altincatal, Chengqing Wu, Pierre Fenaux
BACKGROUND: The phase III MDS-005 study compared lenalidomide versus placebo in red blood cell transfusion-dependent (RBC-TD) patients with lower-risk non-del(5q) myelodysplastic syndromes (MDS), ineligible/refractory to erythropoiesis-stimulating agents. Lenalidomide-treated patients were more likely to achieve transfusion independence (TI) ≥ 8 weeks (26.9% vs. 2.5%; P < .001) and hemoglobin increase ≥ 1.5 g/dL (19.4% vs. 2.5%) versus placebo. PATIENTS AND METHODS: Patients were randomized 2:1 to oral lenalidomide 10 mg once daily or placebo once daily (both on 28-day cycles)...
February 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29426869/open-label-placebo-treatment-for-cancer-related-fatigue-a-randomized-controlled-clinical-trial
#8
Teri W Hoenemeyer, Ted J Kaptchuk, Tapan S Mehta, Kevin R Fontaine
The purpose of this 21-day assessor blinded, randomized-controlled trial was to compare an open-label placebo (OLP) to treatment as usual (TAU) for cancer survivors with fatigue. This was followed by an exploratory 21-day study in which TAU participants received OLPs while OLP participants in the main study were followed after discontinuing placebos. Cancer survivors (N = 74) who completed cancer treatment 6 months to 10 years prior to enrollment reporting at least moderate fatigue (i.e., ≥4 on a 0-10 scale) were randomized to OLP or TAU...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421582/ginseng-phytochemicals-as-therapeutics-in-oncology-recent-perspectives
#9
REVIEW
Fatima Majeed, Fozia Zahur Malik, Zaheer Ahmed, Asma Afreen, Muhammad Naveed Afzal, Nauman Khalid
During the last few decades, cancer has mushroomed as a major health issue; and almost all drugs used for its therapy are very toxic with lethal side effects. Complementary and alternative medicines gain popularity among health professionals in recent era owing to its preventive mechanism against side effect chemotherapeutic drugs. Efforts are focused by scientists to isolate compounds from medicinal plant that have chemotherapeutic attributes; and ability to neutralize the side effects of chemotherapy. Ginseng is an oriental medicinal recipe from Araliceae family and Panax species...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29421164/the-long-term-impact-of-neurofeedback-on-symptom-burden-and-interference-in-patients-with-chronic-chemotherapy-induced-neuropathy-analysis-of-a-randomized-controlled-trial
#10
Sarah Prinsloo, Diane Novy, Larry Driver, Randall Lyle, Lois Ramondetta, Cathy Eng, Gabriel Lopez, Yisheng Li, Lorenzo Cohen
CONTEXT: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment, and may adversely affect quality of life for years. OBJECTIVES: We explored the long-term effects of electroencephalographic (EEG) neurofeedback (NFB) as a treatment for CIPN and other aspects of quality of life (QOL). METHODS: Seventy-one cancer survivors (mean age=62.5; 87% female) with CIPN were randomized to NFB or to a waitlist control group (WLC)...
February 5, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29408395/the-beneficial-role-of-exercise-in-mitigating-doxorubicin-induced-mitochondrionopathy
#11
REVIEW
I Marques-Aleixo, E Santos-Alves, P J Oliveira, P I Moreira, J Magalhães, A Ascensão
Doxorubicin (DOX) is a widely used antineoplastic agent for a wide range of cancers, including hematological malignancies, soft tissue sarcomas and solid tumors. However, DOX exhibits a dose-related toxicity that results in life-threatening cardiomyopathy. In addition to the heart, there is evidence that DOX toxicity extends to other organs. This general toxicity seems to be related to mitochondrial network structural, molecular and functional impairments. Several countermeasures for these negative effects have been proposed, being physical exercise, not only one of the most effective non-pharmacologic strategy but also widely recommended as booster against cancer-related fatigue...
February 2, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29404835/fatigue-and-depressive-symptoms-improve-but-remain-negatively-related-to-work-functioning-over-18-months-after-return-to-work-in-cancer-patients
#12
H F Dorland, F I Abma, S K R Van Zon, R E Stewart, B C Amick, A V Ranchor, C A M Roelen, U Bültmann
PURPOSE: The aims of this study are to investigate the course of work functioning, health status, and work-related factors among cancer patients during 18 months after return to work (RTW) and to examine the associations between these variables and work functioning over time. METHODS: Data were used from the 18-month longitudinal "Work Life after Cancer" (WOLICA) cohort, among 384 cancer patients who resumed work. Linear mixed models were performed to examine the different courses during 18-month follow-up...
February 5, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29401504/anxiety-fatigue-and-attentional-bias-toward-threat-in-patients-with-hematopoietic-tumors
#13
Kohei Koizumi, Jun Tayama, Toshiyuki Ishioka, Hiromi Nakamura-Thomas, Makoto Suzuki, Motohiko Hara, Shigeru Makita, Toyohiro Hamaguchi
Cancer patients with hematopoietic tumors exhibit particularly high rates of anxiety disorders and depression, and often develop negative affect. In addition, psychological problems experienced by cancer patients impair their quality of life. When cancer patients feel anxious, they tend to direct their attention toward stimuli associated with threat in the surrounding environment. If attentional bias occurs in patients with hematopoietic tumors, who are at particular risk of developing negative affect, resolution of the bias could be useful in alleviating their anxiety...
2018: PloS One
https://www.readbyqxmd.com/read/29399917/the-function-of-fatigue-and-illness-perceptions-as-mediators-between-self-efficacy-and-health-related-quality-of-life-during-the-first-year-after-surgery-in-persons-treated-for-colorectal-cancer
#14
Ann-Caroline Johansson, Eva Brink, Christina Cliffordson, Malin Axelsson
AIMS AND OBJECTIVES: The aim of the present study was twofold: 1) to measure changes in health-related quality of life (HRQoL), two dimensions of illness perceptions (i.e., consequences and emotional representations), fatigue and self-efficacy in persons treated for CRC during the first year after surgical treatment, and 2) to study how fatigue, illness perceptions and self-efficacy measured at 3 months affect HRQoL at 12 months post-surgery. BACKGROUND: There are fluctuations in HRQoL during the first year after treatment for colorectal cancer (CRC), and fatigue may negatively influence HRQoL...
February 4, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29397354/napabucasin-versus-placebo-in-refractory-advanced-colorectal-cancer-a-randomised-phase-3-trial
#15
Derek J Jonker, Louise Nott, Takayuki Yoshino, Sharlene Gill, Jeremy Shapiro, Atsushi Ohtsu, John Zalcberg, Michael M Vickers, Alice C Wei, Yuan Gao, Niall C Tebbutt, Ben Markman, Timothy Price, Taito Esaki, Sheryl Koski, Matthew Hitron, Wei Li, Youzhi Li, Nadine M Magoski, Chiang J Li, John Simes, Dongsheng Tu, Christopher J O'Callaghan
BACKGROUND: Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3, which is a poor prognostic factor in colorectal cancer. This study aimed to test napabucasin in advanced colorectal cancer. METHODS: This study was a double-blind randomised phase 3 trial done at 68 centres in Canada, Australia, New Zealand, and Japan. Patients with advanced colorectal cancer with a good Eastern Cooperative Oncology Group (ECOG) performance status (0-1) for whom all available standard therapies had failed were eligible for the study...
January 31, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29394126/biopsychosocial-distress-in-young-adult-oncology-patients-examining-sex-differences-in-sources-of-high-distress-and-requests-for-assistance
#16
Elaine Wheat Dawson, Karen Clark, Richard Obenchain, Matthew J Loscalzo, Jeanelle Folbrecht
PURPOSE: This study examines biopsychosocial problem-related distress and requests for assistance with male and female young adult patients by applying a large-scale analysis among individuals diagnosed with a variety of cancers. METHODS: A retrospective study was conducted involving 630 patients of ages 18-39 treated for cancer at City of Hope between 2009 and 2014. Patients were asked to complete a biopsychosocial problem-related distress touch-screen instrument before treatment as part of their routine clinical care...
February 2, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29390869/sleep-pattern-and-predictors-of-sleep-disturbance-among-family-caregivers-of-terminal-ill-patients-with-cancer-in-taiwan-a-longitudinal-study
#17
Kwo-Chen Lee, Ya-Ling Hsieh, Pi-Chu Lin, Yun-Ping Lin
BACKGROUND: Sleep disturbance commonly has a negative impact on the well-being of family caregivers (FCs) of terminally ill patients with cancer. The effect of sleep disturbance on FCs has not been explored through long-term follow-up studies in Taiwan. OBJECTIVE: The purposes of this study were to (1) identify the trajectory of sleep quality of FCs of terminally ill patients with cancer in Taiwan and (2) examine the determinants of sleep disturbance through a longitudinal follow-up until patient death...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29388275/a-randomized-dose-response-trial-of-aerobic-exercise-and-health-related-quality-of-life-in-colon-cancer-survivors
#18
Justin C Brown, Nevena Damjanov, Kerry S Courneya, Andrea B Troxel, Babette S Zemel, Michael R Rickels, Bonnie Ky, Andrew D Rhim, Anil K Rustgi, Kathryn H Schmitz
OBJECTIVE: To examine the dose-response effects of aerobic exercise on health-related quality of life (HRQoL) among colon cancer survivors. METHODS: Thirty-nine stage I-III colon cancer survivors were randomized to one of three groups: usual-care control, 150 min·wk-1 of aerobic exercise (low-dose), and 300 min·wk-1 of aerobic exercise (high-dose) for six months. HRQoL outcomes included the Short Form (SF)-36 physical and mental component summary, Functional Assessment of Cancer Therapy-Colorectal (FACT-C), Pittsburgh Sleep Quality Index (PSQI), Fear of Cancer Recurrence Inventory (FCRI), Fatigue Symptom Inventory (FSI), and North Central Cancer Treatment Group bowel function questionnaire, assessed at baseline and post intervention...
February 1, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29388071/yoga-for-the-management-of-cancer-treatment-related-toxicities
#19
REVIEW
Po-Ju Lin, Luke J Peppone, Michelle C Janelsins, Supriya G Mohile, Charles S Kamen, Ian R Kleckner, Chunkit Fung, Matthew Asare, Calvin L Cole, Eva Culakova, Karen M Mustian
PURPOSE OF REVIEW: To (1) explain what yoga is, (2) summarize published literature on the efficacy of yoga for managing cancer treatment-related toxicities, (3) provide clinical recommendations on the use of yoga for oncology professionals, and (4) suggest promising areas for future research. RECENT FINDINGS: Based on a total of 24 phase II and one phase III clinical trials, low-intensity forms of yoga, specifically gentle hatha and restorative, are feasible, safe, and effective for treating sleep disruption, cancer-related fatigue, cognitive impairment, psychosocial distress, and musculoskeletal symptoms in cancer patients receiving chemotherapy and radiation and cancer survivors...
February 1, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29383944/the-effects-of-a-culturally-tailored-patient-centered-psychosocial-intervention-in-south-korean-cancer-survivors
#20
Dohun Kim, Sun Ju Chang, Hyun Ok Lee, Seung Hee Lee
This study aimed to develop a culturally tailored, patient-centered psychosocial intervention program and to investigate the effects of the program on health-related quality of life, sleep disturbance, and depression in cancer survivors. This was a one-group pretest and posttest design. A total of 19 cancer survivors participated in the program. The program was designed to have an 8-week duration with one class per week. Every class was composed of a 90-min education session and a 90-min exercise. Among the health-related quality of life subscales, the scores of global health status/quality of life, physical functioning, and emotional functioning at posttest were statistically increased than those at pretest...
January 1, 2018: Clinical Nursing Research
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