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https://www.readbyqxmd.com/read/28238406/the-effect-of-trauma-on-neanderthal-culture-a-mathematical-analysis
#1
W Nakahashi
Traumatic lesions are often observed in ancient skeletal remains. Since ancient medical technology was immature, severely traumatized individuals may have frequently lost the physical ability for cultural skills that demand complex body movements. I develop a mathematical model to analyze the effect of trauma on cultural transmission and apply it to Neanderthal culture using Neanderthal fossil data. I estimate from the data that the proportion of adult individuals who suffered traumatic injuries before death was approximately 0...
February 4, 2017: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
https://www.readbyqxmd.com/read/28238221/acquisition-of-involuntary-spinal-locomotion-spinal-walking-in-dogs-with-irreversible-thoracolumbar-spinal-cord-lesion-81-dogs
#2
A Gallucci, L Dragone, M Menchetti, T Gagliardo, M Pietra, M Cardinali, G Gandini
BACKGROUND: Spinal walking (SW) is described as the acquisition of an involuntary motor function in paraplegic dogs and cats without pain perception affected by a thoracolumbar lesion. Whereas spinal locomotion is well described in cats that underwent training trials after experimental spinal cord resection, less consistent information is available for dogs. HYPOTHESIS: Paraplegic dogs affected by a thoracolumbar complete spinal cord lesion undergoing intensive physical rehabilitation could acquire an autonomous SW gait under field conditions...
February 26, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28237839/systemic-aav8-mediated-gene-therapy-drives-whole-body-correction-of-myotubular-myopathy-in-dogs
#3
David L Mack, Karine Poulard, Melissa A Goddard, Virginie Latournerie, Jessica M Snyder, Robert W Grange, Matthew R Elverman, Jérôme Denard, Philippe Veron, Laurine Buscara, Christine Le Bec, Jean-Yves Hogrel, Annie G Brezovec, Hui Meng, Lin Yang, Fujun Liu, Michael O'Callaghan, Nikhil Gopal, Valerie E Kelly, Barbara K Smith, Jennifer L Strande, Fulvio Mavilio, Alan H Beggs, Federico Mingozzi, Michael W Lawlor, Ana Buj-Bello, Martin K Childers
X-linked myotubular myopathy (XLMTM) results from MTM1 gene mutations and myotubularin deficiency. Most XLMTM patients develop severe muscle weakness leading to respiratory failure and death, typically within 2 years of age. Our objective was to evaluate the efficacy and safety of systemic gene therapy in the p.N155K canine model of XLMTM by performing a dose escalation study. A recombinant adeno-associated virus serotype 8 (rAAV8) vector expressing canine myotubularin (cMTM1) under the muscle-specific desmin promoter (rAAV8-cMTM1) was administered by simple peripheral venous infusion in XLMTM dogs at 10 weeks of age, when signs of the disease are already present...
February 22, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28237009/a-new-method-of-ergonomic-testing-of-gloves-protecting-against-cuts-and-stabs-during-knife-use
#4
Emilia Irzmańska, Tomasz Tokarski
The paper presents a new method of ergonomic evaluation of gloves protecting against cuts and stabs during knife use, consisting of five manual dexterity tests. Two of them were selected based on the available literature and relevant safety standards, and three were developed by the authors. All of the tests were designed to simulate occupational tasks associated with meat processing as performed by the gloved hand in actual workplaces. The tests involved the three most common types of protective gloves (knitted gloves made of a coverspun yarn, metal mesh gloves, and metal mesh gloves with an ergonomic polyurethane tightener) and were conducted on a group of 20 males...
May 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28236918/morbidity-and-mortality-after-emergency-lower-extremity-embolectomy
#5
Sergio Casillas-Berumen, Lili Sadri, Alik Farber, Mohammad H Eslami, Jeffrey A Kalish, Denis Rybin, Gheorghe Doros, Jeffrey J Siracuse
OBJECTIVE: Emergency lower extremity embolectomy is a common vascular surgical procedure that has poorly defined outcomes. Our goal was to define the perioperative morbidity for emergency embolectomy and develop a risk prediction model for perioperative mortality. METHODS: The American College of Surgeons National Surgical Quality Improvement database was queried to identify patients undergoing emergency unilateral and lower extremity embolectomy. Patients with previous critical limb ischemia, bilateral embolectomy, nonemergency indication, and those undergoing concurrent bypass were excluded...
March 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28236079/the-2017-abjs-nicolas-andry-award-advancing-personalized-medicine-for-clubfoot-through-translational-research
#6
Matthew B Dobbs, Christina A Gurnett
BACKGROUND: Clubfoot is one of the most common pediatric orthopaedic disorders. While the Ponseti method has revolutionized clubfoot treatment, it is not effective for all patients. When the Ponseti method does not correct the foot, patients are at risk for lifelong disability and may require more-extensive surgery. QUESTIONS/PURPOSES: (1) What genetic and morphologic abnormalities contribute to the development of clubfoot? (2) How can this information be used to devise personalized treatment paradigms for patients with clubfoot? METHODS: Human gene sequencing, molecular genetic engineering of mouse models of clubfoot, MRI of clubfoot, and development of new treatment methods all have been used by our group to understand the biological basis and improve therapy for this group of disorders...
February 24, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28235582/repeated-removal-of-developing-limb-buds-permanently-reduces-appendage-size-in-the-highly-regenerative-axolotl
#7
Donald M Bryant, Konstantinos Sousounis, Johanna E Farkas, Sevara Bryant, Neng Thao, Anna R Guzikowski, James R Monaghan, Michael Levin, Jessica L Whited
Matching appendage size to body size is fundamental to animal function. Generating an appropriately-sized appendage is a robust process executed during development which is also critical for regeneration. When challenged, larger animals are programmed to regenerate larger limbs than smaller animals within a single species. Understanding this process has important implications for regenerative medicine. To approach this complex question, models with altered appendage size:body size ratios are required. We hypothesized that repeatedly challenging axolotls to regrow limb buds would affect their developmental program resulting in altered target morphology...
February 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28231269/a-mouse-model-of-paralytic-myelitis-caused-by-enterovirus-d68
#8
Alison M Hixon, Guixia Yu, J Smith Leser, Shigeo Yagi, Penny Clarke, Charles Y Chiu, Kenneth L Tyler
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory disease. Up to half of the 2014 AFM patients had EV-D68 RNA detected by RT-PCR in their respiratory secretions, although EV-D68 was only detected in cerebrospinal fluid (CSF) from one 2014 AFM patient. Given previously described molecular and epidemiologic associations between EV-D68 and AFM, we sought to develop an animal model by screening seven EV-D68 strains for the ability to induce neurological disease in neonatal mice...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28230612/nationwide-survey-of-pediatric-acute-osteomyelitis-in-the-usa
#9
Yusuke Okubo, Kotaro Nochioka, Marcia Testa
: The epidemiology of pediatric acute osteomyelitis in the USA, such as annual hospitalization rates and disparities with respect to age, sex, race/ethnicity, and socioeconomic status, remains unknown. We obtained discharge records of hospitalized patients with acute osteomyelitis younger than 20 years of age from the Kids Inpatient Database for 2006, 2009, and 2012. We weighted the records to estimate the number of hospitalizations in the USA and calculated the annual rates of hospitalization because of acute osteomyelitis...
February 22, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28230213/knock-in-human-fgfr3-achondroplasia-mutation-as-a-mouse-model-for-human-skeletal-dysplasia
#10
Yi-Ching Lee, I-Wen Song, Ya-Ju Pai, Sheng-De Chen, Yuan-Tsong Chen
Achondroplasia (ACH), the most common genetic dwarfism in human, is caused by a gain-of function mutation in fibroblast growth factor receptor 3 (FGFR3). Currently, there is no effective treatment for ACH. The development of an appropriate human-relevant model is important for testing potential therapeutic interventions before human clinical trials. Here, we have generated an ACH mouse model in which the endogenous mouse Fgfr3 gene was replaced with human FGFR3(G380R) (FGFR3(ACH)) cDNA, the most common mutation in human ACH...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229193/osseointegrated-prostheses-for-rehabilitation-following-amputation-the-pioneering-swedish-model
#11
Yan Li, Rickard Brånemark
The direct attachment of osseointegrated (OI) prostheses to the skeleton avoids the inherent problems of socket suspension. It also provides physiological weight bearing, improved range of motion in the proximal joint, as well as osseoperceptive sensory feedback, enabling better control of the artificial limbs by amputees. The present article briefly reviews the pioneering efforts on extremity osseointegration surgeries in Sweden and the development of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) program...
February 22, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28228103/disease-manifestations-and-burden-of-illness-in-patients-with-acid-sphingomyelinase-deficiency-asmd
#12
REVIEW
Margaret M McGovern, Ruzan Avetisyan, Bernd-Jan Sanson, Olivier Lidove
Acid sphingomyelinase deficiency (ASMD), a rare lysosomal storage disease, is an autosomal recessive genetic disorder caused by different SMPD1 mutations. Historically, ASMD has been classified as Niemann-Pick disease (NPD) types A (NPD A) and B (NPD B). NPD A is associated with a uniformly devastating disease course, with rapidly progressing psychomotor degeneration, leading to death typically by the age of 3 years, most often from respiratory failure. In contrast, the clinical phenotype and life expectancy of patients with NPD B may vary widely...
February 23, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28227918/longitudinal-wearable-tremor-measurement-system-with-activity-recognition-algorithms-for-upper-limb-tremor
#13
Jeonghee Kim, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Jeonghee Kim, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Claire Parnell, Thomas Wichmann, Stephen P DeWeerth, Jeonghee Kim
Assessments of tremor characteristics by movement disorder physicians are usually done at single time points in clinic settings, so that the description of the tremor does not take into account the dependence of the tremor on specific behavioral situations. Moreover, treatment-induced changes in tremor or behavior cannot be quantitatively tracked for extended periods of time. We developed a wearable tremor measurement system with tremor and activity recognition algorithms for long-term upper limb behavior tracking, to characterize tremor characteristics and treatment effects in their daily lives...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227836/exerciser-for-rehabilitation-of-the-arm-era-development-and-unique-features-of-a-3d-end-effector-robot
#14
Marie-Helene Milot, Mathieu Hamel, Philippe-Olivier Provost, Julien Bernier-Ouellet, Maxime Dupuis, Dominic Letourneau, Simon Briere, Francois Michaud, Marie-Helene Milot, Mathieu Hamel, Philippe-Olivier Provost, Julien Bernier-Ouellet, Maxime Dupuis, Dominic Letourneau, Simon Briere, Francois Michaud, Philippe-Olivier Provost, Dominic Letourneau, Maxime Dupuis, Marie-Helene Milot, Francois Michaud, Mathieu Hamel, Julien Bernier-Ouellet, Simon Briere
Stroke is one of the leading causes of disability worldwide. Consequently, many stroke survivors exhibit difficulties undergoing voluntary movement in their affected upper limb, compromising their functional performance and level of independence. To minimize the negative impact of stroke disabilities, exercises are recognized as a key element in post-stroke rehabilitation. In order to provide the practice of exercises in a uniform and controlled manner as well as increasing the efficiency of therapists' interventions, robotic training has been found, and continues to prove itself, as an innovative intervention for post-stroke rehabilitation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227654/preliminary-results-for-an-adaptive-pattern-recognition-system-for-novel-users-using-a-powered-lower-limb-prosthesis
#15
John A Spanias, Ann M Simon, Eric J Perreault, Levi J Hargrove, John A Spanias, Ann M Simon, Eric J Perreault, Levi J Hargrove, Eric J Perreault, John A Spanias, Ann M Simon, Levi J Hargrove
Powered prosthetic legs are capable of improving the gait of lower limb amputees. Pattern recognition systems for these devices allow amputees to transition between different locomotion modes in a way that is seamless and transparent to the user. However, the potential of these systems is diminished because they require large amounts of training data that is burdensome to collect. To reduce the effort required to acquire these data, we developed an adaptive pattern recognition system that automatically learns from subject-specific data as the user is ambulating...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227653/delaying-ambulation-mode-transitions-in-a-powered-knee-ankle-prosthesis
#16
Ann M Simon, John A Spanias, Kimberly A Ingraham, Levi J Hargrove, Ann M Simon, John A Spanias, Kimberly A Ingraham, Levi J Hargrove, John A Spanias, Ann M Simon, Kimberly A Ingraham, Levi J Hargrove
Powered knee and ankle prostheses have the potential to improve the mobility of individuals with a lower limb amputation. As the number of different ambulation modes the prosthesis can be configured for increases, so too does the challenge of how to best transition the prosthesis between these modes. Pattern recognition systems have been suggested as a means to provide seamless and natural transitions, although error rates need to be reduced for these systems to be clinical viable. Delaying mode transitions by a small window may be one way to reduce error rates and improve reliability...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227651/adaptive-control-of-powered-transfemoral-prostheses-based-on-adaptive-dynamic-programming
#17
Yue Wen, Ming Liu, Jennie Si, He Helen Huang, Yue Wen, Ming Liu, Jennie Si, He Huang, He Helen Huang, Yue Wen, Ming Liu, Jennie Si
In this study, we developed and tested a novel adaptive controller for powered transfemoral prostheses. Adaptive dynamic programming (ADP) was implemented within the prosthesis control to complement the existing finite state impedance control (FS-IC) in a prototypic active-transfemoral prosthesis (ATP). The ADP controller interacts with the human user-prosthesis system, observes the prosthesis user's dynamic states during walking, and learns to personalize user performance properties via online adaptation to meet the individual user's objectives...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227650/real-time-gait-event-detection-for-lower-limb-amputees-using-a-single-wearable-sensor
#18
H F Maqbool, M A B Husman, M I Awad, A Abouhossein, P Mehryar, N Iqbal, A A Dehghani-Sanij, H F Maqbool, M A B Husman, M I Awad, A Abouhossein, P Mehryar, N Iqbal, A A Dehghani-Sanij, M A B Husman, M I Awad, N Iqbal, P Mehryar, H F Maqbool, A Abouhossein, A A Dehghani-Sanij
This paper presents a rule-based real-time gait event/phase detection system (R-GEDS) using a shank mounted inertial measurement unit (IMU) for lower limb amputees during the level ground walking. Development of the algorithm is based on the shank angular velocity in the sagittal plane and linear acceleration signal in the shank longitudinal direction. System performance was evaluated with four control subjects (CS) and one transfemoral amputee (TFA) and the results were validated with four FlexiForce footswitches (FSW)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227568/system-to-induce-and-measure-embodiment-of-an-artificial-hand-with-programmable-convergent-visual-and-tactile-stimuli
#19
Heather L Benz, Talia R Sieff, Mahsa Alborz, Kimberly Kontson, Elizabeth Kilpatrick, Eugene F Civillico, Heather L Benz, Talia R Sieff, Mahsa Alborz, Kimberly Kontson, Elizabeth Kilpatrick, Eugene F Civillico, Kimberly Kontson, Heather L Benz, Talia R Sieff, Elizabeth Kilpatrick, Eugene F Civillico, Mahsa Alborz
The sense of prosthesis embodiment, or the feeling that the device has been incorporated into a user's body image, may be enhanced by emerging technology such as invasive electrical stimulation for sensory feedback. In turn, prosthesis embodiment may be linked to increased prosthesis use and improved functional outcomes. We describe the development of a tool to assay artificial hand embodiment in a quantitative way in people with intact limbs, and characterize its operation. The system delivers temporally coordinated visual and tactile stimuli at a programmable latency while recording limb temperature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227556/case-studies-in-poststroke-hemiplegic-patients-using-semul-a-passive-2-dof-rehabilitation-robot
#20
Ken'ichi Koyanagi, Yuya Kuwahara, Takehiro Kamida, Takuya Ozawa, Rieko Mizukami, Kiyokazu Genda, Ayaka Mori, Tatsuo Motoyoshi, Hiroyuki Masuta, Toru Oshima, Ken'ichi Koyanagi, Yuya Kuwahara, Takehiro Kamida, Takuya Ozawa, Rieko Mizukami, Kiyokazu Genda, Ayaka Mori, Tatsuo Motoyoshi, Hiroyuki Masuta, Toru Oshima, Tatsuo Motoyoshi, Toru Oshima, Rieko Mizukami, Kiyokazu Genda, Takehiro Kamida, Takuya Ozawa, Ken'ichi Koyanagi, Ayaka Mori, Yuya Kuwahara, Hiroyuki Masuta
Following stroke, rehabilitation exercises paired with medical treatment are important for the recovery and maintenance of upper limb function. We developed a 2-DOF passive haptic system for upper limb rehabilitation and software focusing on reaching exercises, known as the coin collecting program, which provides training and evaluation of motor function, particularly dexterity. Past studies have revealed quantitative, reproducible evaluation indices using this software. In this paper, we compared case studies of post-stroke patients with results from healthy participants, and confirmed the reliability of the evaluation indices in grading or scoring motor skills...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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