Christine Prodinger, Subhanitthaya Chottianchaiwat, Jemima E Mellerio, John A McGrath, Linda Ozoemena, Lu Liu, William Moore, Martin Laimer, Gabriela Petrof, Anna E Martinez
BACKGROUND/OBJECTIVES: Laryngo-onycho-cutaneous syndrome (LOC) is a rare subtype of junctional epidermolysis bullosa (JEB), featuring aberrant granulation tissue formation in the skin, larynx, and eyes. So far, three mutations including the specific (founder) mutation in exon 39 of LAMA3 (c.151dup) have been identified, but sparse data exists regarding the natural history, the genotype-phenotype correlation, and its differentiation from other JEB types. METHODS: We reviewed our pediatric EB database to identify English children with clinical and genetically diagnosed LOC within the last 15 years...
September 2021: Pediatric Dermatology