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Cascade of HIV care

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https://www.readbyqxmd.com/read/28533167/performance-of-the-antiretroviral-treatment-program-in-ethiopia-2005-2015-strengths-and-weaknesses-toward-ending-aids
#1
Yibeltal Assefa, Charles F Gilks, Lutgarde Lynen, Owain Williams, Peter S Hill, Taye Tolera, Alankar Malvia, Wim Van Damme
BACKGROUND: Ethiopia is one of the countries which has scaled up antiretroviral treatment (ART) over the past decade. This study reviews the performance of the ART program in Ethiopia during the past decade, and identifies successes and weaknesses toward ending AIDS in the country. METHODS: A review and synthesis of data was conducted using multiple data sources: reports from all health facilities in Ethiopia to the Federal Ministry of Health, HIV/AIDS estimates and projections, and retrospective cohort and cross-sectional studies conducted between 2005/6 and 2014/15...
May 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28520807/time-from-hiv-diagnosis-to-commencement-of-antiretroviral-therapy-as-an-indicator-to-supplement-the-hiv-cascade-dramatic-fall-from-2011-to-2015
#2
Nicholas A Medland, Eric P F Chow, James H McMahon, Julian H Elliott, Jennifer F Hoy, Christopher K Fairley
INTRODUCTION: The HIV care cascade is increasingly used to evaluate HIV treatment programs at the population level. However, the cascade indicators lack the ability to show changes over time, which reduces their utility to guide health policy. Alternatives have been proposed but are complex or result in a delay in results. We propose a new indicator of ART uptake, the time from HIV diagnosis to commencement of ART, and compare it to the existing cascade indicator of proportion of patients on treatment and the WHO proposed cohort cascade indicator of proportion of patients on treatment within one year of diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/28511680/cohort-profile-seek-test-treat-and-retain-united-states-criminal-justice-cohort
#3
Redonna Chandler, Michael S Gordon, Bridget Kruszka, Lauren N Strand, Frederick L Altice, Curt G Beckwith, Mary L Biggs, William Cunningham, J A Chris Delaney, Patrick M Flynn, Carol E Golin, Kevin Knight, Alex H Kral, Irene Kuo, Jennifer Lorvick, Robin M Nance, Lawrence J Ouellet, Josiah D Rich, Stanley Sacks, David Seal, Anne Spaulding, Sandra A Springer, Faye Taxman, David Wohl, Jeremy D Young, Rebekah Young, Heidi M Crane
BACKGROUND: The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement. METHODS: The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved in the criminal justice system, often but not exclusively for reasons related to substance use...
May 16, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28498188/the-impact-of-structured-mentor-mother-programs-on-presentation-for-early-infant-diagnosis-testing-in-rural-north-central-nigeria-a-prospective-paired-cohort-study
#4
Nadia A Sam-Agudu, Habib O Ramadhani, Christopher Isah, Salome Erekaha, Chinenye Fan-Osuala, Udochisom Anaba, Ebunoluwa A Adejuyigbe, Manhattan Charurat
BACKGROUND: Early infant diagnosis (EID) by 2 months of age is an important prevention of mother-to-child cascade step that serves as an early postpartum indicator of program success. Uptake and timely presentation for infant HIV diagnosis are significant challenges in resource-limited settings. Few studies on maternal peer support (PS) have demonstrated impact on EID. The MoMent study evaluated the impact of structured PS on timely presentation for EID testing in rural North-Central Nigeria...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28471841/a-flow-based-model-of-the-hiv-care-continuum-in-the-united-states
#5
Gregg S Gonsalves, A David Paltiel, Paul D Cleary, Michael John Gill, Mari M Kitahata, Peter F Rebeiro, Michael J Silverberg, Michael Horberg, Alison G Abraham, Keri N Althoff, Richard Moore, Ronald J Bosch, H Irene Hall, Edward H Kaplan
BACKGROUND: Understanding the flow of patients through the continuum of HIV care is critical to determine how best to intervene so that the proportion of HIV-infected persons who are on antiretroviral treatment and virally suppressed is as large as possible. METHODS: Using immunological and virological data from the Centers for Disease Control and Prevention and the North American AIDS Cohort Collaboration on Research and Design from 2009-2012, we estimated the distribution of time spent in and dropout probability from each stage in the continuum of HIV care...
April 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28465650/exploratory-analysis-of-time-from-hiv-diagnosis-to-art-start-factors-and-effect-on-survival-a-longitudinal-follow-up-study-at-seven-teaching-hospitals-in-ethiopia
#6
Alula M Teklu, Kesetebirhan Delele, Mulu Abraha, Bekele Belayhun, Esayas Kebede Gudina, Abiy Nega
BACKGROUND: The HIV care in Ethiopia has reached 79% coverage. The timeliness of the care provided at the different levels in the course of the disease starting from knowing HIV positive status to ART initiation is not well known. This study intends to explore the timing of the care seeking, the care provision and associated factors. METHODS: This is a longitudinal follow-up study at seven university hospitals. Patients enrolled in HIV care from September 2005 to December 2013 and aged ≥14 years were studied...
February 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28459881/facilitators-and-barriers-for-retention-in-hiv-care-between-testing-and-treatment-in-asia-a-study-in-bangladesh-indonesia-lao-nepal-pakistan-philippines-and-vietnam
#7
Sushil Koirala, Keshab Deuba, Oranuch Nampaisan, Gaetano Marrone, Anna Mia Ekström
INTRODUCTION: The need for efficient retention in HIV care is more evident than ever because of the expansion of earlier ART initiation and the shift towards 'Test and Treat'. This study assesses factors affecting participation in the HIV care cascade among people living with HIV (PLHIV) in the Asia-Pacific Region. METHODS: A total of 7843 PLHIV aged 18-50 years were recruited using targeted and venue-based sampling between October 1, 2012, and May 31, 2013, across 59 sites in 7 countries (Bangladesh, Indonesia, Lao People's Democratic Republic (Lao PDR), Nepal, Pakistan, Philippines and Vietnam)...
2017: PloS One
https://www.readbyqxmd.com/read/28441975/seek-test-treat-substance-using-women-in-the-hiv-treatment-cascade-in-south-africa
#8
Wendee M Wechsberg, Charles van der Horst, Jacqueline Ndirangu, Irene A Doherty, Tracy Kline, Felicia A Browne, Jennifer M Belus, Robin Nance, William A Zule
BACKGROUND: Women in South Africa who use alcohol and other drugs face multiple barriers to HIV care. These barriers make it difficult for women to progress through each step in the HIV treatment cascade from diagnosis to treatment initiation and adherence. This paper examines correlates of HIV status, newly diagnosed HIV status, and use of antiretroviral therapy (ART). METHODS: Outreach workers recruited sexually active Black African women who used substances in Pretoria as part of a U...
April 26, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28440604/a-proposed-novel-framework-for-monitoring-and-evaluation-of-the-cascade-of-hiv-associated-tb-care-at-the-health-facility-level
#9
Colleen F Hanrahan, Annelies Van Rie
INTRODUCTION: The rapid and accurate diagnosis of HIV-associated tuberculosis (TB), timely initiation of curative or preventative treatment and assurance of favourable treatment outcomes is a complex process. The current system of monitoring and reporting TB diagnosis and treatment does not include several key aspects of the care cascade, and may obscure systematic bottlenecks, inefficiencies or sources of sub-optimal care. METHODS: We critically reviewed the current World Health Organizations recommended system of monitoring and reporting, and identified the following key deficiencies that could limit the ability of healthcare workers to identify structural problems in the provision of TB/HIV care...
April 20, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28431923/sources-of-racial-disparities-in-hiv-prevalence-in-men-who-have-sex-with-men-in-atlanta-ga-usa-a-modelling-study
#10
Steven M Goodreau, Eli S Rosenberg, Samuel M Jenness, Nicole Luisi, Sarah E Stansfield, Gregorio A Millett, Patrick S Sullivan
BACKGROUND: In the USA, men who have sex men (MSM) are at high risk for HIV, and black MSM have a substantially higher prevalence of infection than white MSM. We created a simulation model to assess the strength of existing hypotheses and data that account for these disparities. METHODS: We built a dynamic, stochastic, agent-based network model of black and white MSM aged 18-39 years in Atlanta, GA, USA, that incorporated race-specific individual and dyadic-level prevention and risk behaviours, network attributes, and care patterns...
April 18, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28425903/improving-linkage-to-hiv-care-at-low-threshold-sti-hiv-testing-sites-an-evaluation-of-the-immediate-staging-pilot-project-in-vancouver-british-columbia
#11
Bobbi Brownrigg, Darlene Taylor, Felicia Phan, Irvine Sandstra, Rochelle Stimpson, Rolando Barrios, Richard Lester, Gina Ogilvie
OBJECTIVES: The objective of the Immediate Staging Pilot Project (ISPP) was to improve linkage to human immunodeficiency virus (HIV) care by increasing the number of referrals made to HIV care, and to decrease the time between diagnosis and linkage to care for newly diagnosed HIV clients. This pilot had the potential to decrease HIV transmission at a population level by engaging clients in treatment earlier. SETTING: The Bute Street Clinic and Health Initiative for Men Clinic on Davie in Vancouver, British Columbia are low-threshold public health facilities providing HIV/STI testing primarily to men who have sex with men (MSM)...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28406598/factors-associated-with-sex-work-involvement-among-transgender-women-in-jamaica-a-cross-sectional-study
#12
Carmen H Logie, Ying Wang, Ashley Lacombe-Duncan, Nicolette Jones, Uzma Ahmed, Kandasi Levermore, Ava Neil, Tyrone Ellis, Nicolette Bryan, Annecka Marshall, Peter A Newman
INTRODUCTION: Transgender women are disproportionately impacted by HIV. Transgender women involved in sex work may experience exacerbated violence, social exclusion, and HIV vulnerabilities, in comparison with non-sex work-involved transgender women. Scant research has investigated sex work among transgender women in the Caribbean, including Jamaica, where transgender women report pervasive violence. The study objective was to examine factors associated with sex work involvement among transgender women in Jamaica...
April 6, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28401415/monitoring-hiv-treatment-and-the-health-sector-cascade-from-treatment-numbers-to-impact
#13
Daniel Low-Beer, Michel Beusenberg, Chika Hayashi, Txema Calleja, Kimberly Marsh, Awandha Mamahit, Theresa Babovic, Gottfried Hirnschall
Although not originally part of the MDGs, HIV treatment has been at the center of global HIV reporting since 2003, marked by achievement of the target of 15 million people receiving treatment before 2015 and 18.2 million (16.1-19.0 million) by mid 2016. Monitoring of treatment has been strengthened with harmonized partner reporting and accountability with regular, annual reports. Beyond treatment numbers, increasingly measures of treatment adherence, retention and outcomes have been reported though with varying quality and completeness...
April 11, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28399160/a-new-cascade-of-hiv-care-for-the-era-of-treat-all
#14
Matthew P Fox, Sydney Rosen
Matthew Fox and Sydney Rosen discuss a cascade of HIV care adapted to WHO-recommended antiretroviral therapy irrespective of CD4 cell count.
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28398994/using-the-pmtct-cascade-to-accelerate-achievement-of-the-global-plan-goals
#15
Elizabeth Hamilton, Bernard Bossiky, John Ditekemena, Godfrey Esiru, Franck Fwamba, Ameena E Goga, Mary Pat Kieffer, Landry D Tsague, Roland van de Ven, Rose Wafula, Laura Guay
BACKGROUND: Development of country plans for prevention of mother-to-child HIV transmission (PMTCT), including expansion of comprehensive, integrated services, was key to Global Plan achievements. APPROACHES: Use of the PMTCT cascade, an evolving series of sequential steps needed to maximize the health of women and HIV-free survival of infants, was critical for development and implementation of PMTCT plans. Regular review of cascade data at national/subnational levels was a tool for evidence-based decision making, identifying areas of greatest need at each level, and targeting program interventions to address specific gaps...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28397527/it-helps-me-live-sends-my-children-to-school-and-feeds-me-a-qualitative-study-of-how-food-and-cash-incentives-may-improve-adherence-to-treatment-and-care-among-adults-living-with-hiv-in-tanzania
#16
Nancy L Czaicki, Agatha Mnyippembe, Madeline Blodgett, Prosper Njau, Sandra I McCoy
Financial and in-kind incentives have been shown to improve outcomes along the HIV care cascade, however the potential mechanismsthrough which they work remain unclear. To identify the pathways through which incentives improve retention in care and adherence to antiretroviral therapy (ART), we conducted a qualitative study with participants in a trial evaluating conditional food and cash incentives for HIV-positive food insecure adults in Shinyanga, Tanzania. We found that the incentives acted through three pathways to potentially increase retention in care and adherence to ART: (1) addressing competing needs and offsetting opportunity costs associated with clinic attendance, (2) alleviating stress associated with attending clinic and meeting basic needs, and (3) by potentially increasing motivation...
April 11, 2017: AIDS Care
https://www.readbyqxmd.com/read/28387654/ending-aids-as-a-public-health-threat-by-2030-scientific-developments-from-the-2016-interest-conference-in-yaound%C3%A3-cameroon
#17
Catherine A Hankins, Sinata Koulla-Shiro, Peter Kilmarx, Guido Ferrari, Mauro Schechter, Coumba Touré Kane, François Venter, Charles Ab Boucher, Anna-Laura Ross, Debrework Zewdie, Serge Paul Eholié, Elly Katabira
The underpinning theme of the 2016 INTEREST Conference held in Yaoundé, Cameroon, 3-6 May 2016 was ending AIDS as a public health threat by 2030. Focused primarily on HIV treatment, pathogenesis and prevention research in resource-limited settings, the conference attracted 369 active delegates from 34 countries, of which 22 were in Africa. Presentations on treatment optimization, acquired drug resistance, care of children and adolescents, laboratory monitoring and diagnostics, implementation challenges, HIV prevention, key populations, vaccine and cure, hepatitis C, mHealth, financing the HIV response and emerging pathogens, were accompanied by oral, mini-oral and poster presentations...
April 7, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28364566/identifying-gaps-in-hiv-service-delivery-across-the-diagnosis-to-treatment-cascade-findings-from-health-facility-surveys-in-six-sub-saharan-countries
#18
Kathryn Church, Kazuyo Machiyama, Jim Todd, Brian Njamwea, Mary Mwangome, Vicky Hosegood, Janet Michel, Samuel Oti, Constance Nyamukapa, Amelia Crampin, Nyaguara Amek, Gertrude Nakigozi, Denna Michael, F Xavier Gómez-Olivé, Jessica Nakiyingi-Miiro, Basia Zaba, Alison Wringe
INTRODUCTION: Despite the rollout of antiretroviral therapy (ART), challenges remain in ensuring timely access to care and treatment for people living with HIV. As part of a multi-country study to investigate HIV mortality, we conducted health facility surveys within 10 health and demographic surveillance system sites across six countries in Eastern and Southern Africa to investigate clinic-level factors influencing (i) use of HIV testing services, (ii) use of HIV care and treatment and (iii) patient retention on ART...
January 12, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28325068/the-relationship-between-health-worker-stigma-and-uptake-of-hiv-counseling-and-testing-and-utilization-of-non-hiv-health-services-the-experience-of-male-and-female-sex-workers-in-kenya
#19
Laura Nyblade, Aditi Reddy, David Mbote, John Kraemer, Melissa Stockton, Caroline Kemunto, Karol Krotki, Javier Morla, Stella Njuguna, Arin Dutta, Catherine Barker
The barrier HIV-stigma presents to the HIV treatment cascade is increasingly documented; however less is known about female and male sex worker engagement in and the influence of sex-work stigma on the HIV care continuum. While stigma occurs in all spheres of life, stigma within health services may be particularly detrimental to health seeking behaviors. Therefore, we present levels of sex-work stigma from healthcare workers (HCW) among male and female sex workers in Kenya, and explore the relationship between sex-work stigma and HIV counseling and testing...
March 22, 2017: AIDS Care
https://www.readbyqxmd.com/read/28319197/the-hiv-care-cascade-japanese-perspectives
#20
Aikichi Iwamoto, Rikizo Taira, Yoshiyuki Yokomaku, Tomohiko Koibuchi, Mahbubur Rahman, Yoko Izumi, Kenji Tadokoro
Japan has been known as a low HIV-prevalence country with a concentrated epidemic among high-risk groups. However, it has not been determined whether Japan meets the 90-90-90 goals set by the Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO). Moreover, to date, the HIV care cascade has not been examined. We estimated the total number of diagnosed people living with HIV/AIDS (PLWHA) (n = 22,840) based on legal reports to the Ministry of Health, Labour and Welfare by subtracting the number of foreigners who left Japan (n = 2,273) and deaths (n = 2,321) from the cumulative diagnosis report (n = 27,434)...
2017: PloS One
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