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https://www.readbyqxmd.com/read/29460226/genetic-cluster-analysis-for-hiv-prevention
#1
REVIEW
Mary Kate Grabowski, Joshua T Herbeck, Art F Y Poon
PURPOSE OF REVIEW: This review summarizes the use of genetic similarity clusters to understand HIV transmission and inform prevention efforts. RECENT FINDINGS: Recent emphases include the development of real-time cluster identification in order to interrupt transmission chains, the use of clusters to estimate rates of transmission along the HIV care cascade, and the extension of cluster analyses to understand transmission in the generalized epidemics of sub-Saharan Africa...
February 19, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29458337/hiv-1-transmission-and-survival-according-to-feeding-options-in-infants-born-to-hiv-infected-women-in-yaound%C3%A3-cameroon
#2
Anne Esther Njom Nlend, Annie Carole Nga Motaze, Arsene Sandie, Joseph Fokam
BACKGROUND: Evidence of 24-months survival in the frame of prevention of mother-to-child transmission (PMTCT) cascade-care is scare from routine programs in sub-Saharan African (SSA) settings. Specifically, data on infant outcomes according to feeding options remain largely unknown by month-24, thus limiting its breath for public-health recommendations toward eliminating new pediatric HIV-1 infections and improving care. We sought to evaluate HIV-1 vertical transmission and infant survival rates according to feeding options...
February 19, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29454322/using-ehealth-to-engage-and-retain-priority-populations-in-the-hiv-treatment-and-care-cascade-in-the-asia-pacific-region-a-systematic-review-of-literature
#3
Julianita Purnomo, Katherine Coote, Limin Mao, Ling Fan, Julian Gold, Raghib Ahmad, Lei Zhang
BACKGROUND: The exponential growth in the reach and development of new technologies over the past decade means that mobile technologies and social media play an increasingly important role in service delivery models to maximise HIV testing and access to treatment and care. This systematic review examines the impact of electronic and mobile technologies in medical care (eHealth) in the linkage to and retention of priority populations in the HIV treatment and care cascade, focussing on the Asia-Pacific region...
February 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29438439/mother-to-child-transmission-of-hiv-in-brazil-data-from-the-birth-in-brazil-study-a-national-hospital-based-study
#4
Rosa Maria Soares Madeira Domingues, Valeria Saraceni, Maria do Carmo Leal
AIMS: to estimate the mother to child transmission (MTCT) of HIV among infected pregnant women identified in the "Birth in Brazil" study and to evaluate care practices provided in order to identify missed opportunities at preventing the MTCT of HIV infection in the country. METHODS: Descriptive study using data obtained from the consultation of different databases: the "Birth in Brazil" study database and the Brazilian National Information Systems (NIS) databases...
2018: PloS One
https://www.readbyqxmd.com/read/29381257/completion-of-the-tuberculosis-care-cascade-in-a-community-based-hiv-linkage-to-care-study-in-south-africa-and-uganda
#5
Adrienne E Shapiro, Alastair van Heerden, Torin T Schaafsma, James P Hughes, Jared M Baeten, Heidi van Rooyen, Elioda Tumwesigye, Connie L Celum, Ruanne V Barnabas
INTRODUCTION: Tuberculosis (TB) is the leading cause of HIV-associated mortality in Africa. As HIV testing, linkage to care and antiretroviral treatment initiation intensify to meet UNAIDS targets, it is not known what effect these efforts will have on TB detection and prevention. We aimed to characterize the TB care cascade of screening, diagnostic testing, treatment and provision of isoniazid preventive therapy (IPT) in a study of community-based HIV screening and linkage to care and determine whether symptom screening results affected progress along the cascade...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29378622/maximizing-adherence-and-retention-for-women-living-with-hiv-and-their-infants-in-kenya-motivate-study-study-protocol-for-a-randomized-controlled-trial
#6
Thomas A Odeny, Maricianah Onono, Kevin Owuor, Anna Helova, Iris Wanga, Elizabeth A Bukusi, Janet M Turan, Lisa L Abuogi
BACKGROUND: Successful completion and retention throughout the multi-step cascade of prevention of mother-to-child HIV transmission (PMTCT) remains difficult to achieve. The Mother and Infant Visit Adherence and Treatment Engagement study aims to evaluate the effect of mobile text messaging, community-based mentor mothers (cMMs), or both on increasing antiretroviral therapy (ART) adherence, retention in HIV care, maternal viral load suppression, and mother-to-child HIV transmission for mother-infant pairs receiving lifelong ART...
January 29, 2018: Trials
https://www.readbyqxmd.com/read/29369949/using-choice-architecture-to-integrate-substance-use-services-with-primary-care-commentary-on-donohue-et-al
#7
Leo Beletsky
: At a time when death and disability linked to problematic substance use have reached crisis levels, integration of substance use disorder (SUD) services into primary care settings is a clear national priority. Incentive-based interventions can catalyze such adoption, but have thus far demonstrated limited efficaciousness. Behavioral Economics can inform efforts to incentivize healthcare providers to adopt SUD interventions. Choice architecture principles dictate pegging rewards to defined quality metrics, improving provider information about effective and cost-effective practices, and reducing barriers to SUD service provision through technological tools, tackling stigma, and addressing real and perceived regulatory burdens and risks...
February 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29356376/boosting-art-uptake-and-retention-among-hiv-infected-pregnant-and-breastfeeding-women-and-their-infants-the-promise-of-innovative-service-delivery-models
#8
Meena Srivastava, David Sullivan, B Ryan Phelps, Surbhi Modi, Laura N Broyles
INTRODUCTION: With the rapid scale-up of antiretroviral treatment (ART) in the "Treat All" era, there has been increasing emphasis on using differentiated models of HIV service delivery. The gaps within the clinical cascade for mothers and their infants suggest that current service delivery models are not meeting families' needs and prompt re-consideration of how services are provided. This article will explore considerations for differentiated care and encourage the ongoing increase of ART coverage through innovative strategies while also addressing the unique needs of mothers and infants...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29291251/gaps-in-the-child-tuberculosis-care-cascade-in-32-rural-communities-in-uganda-and-kenya
#9
Florence Mwangwa, Gabriel Chamie, Dalsone Kwarisiima, James Ayieko, Asiphas Owaraganise, Theodore D Ruel, Albert Plenty, Khai Hoan Tram, Tamara D Clark, Craig R Cohen, Elizabeth A Bukusi, Maya Petersen, Moses R Kamya, Edwin D Charlebois, Diane V Havlir, Carina Marquez
Background: Reducing tuberculosis (TB) deaths among children requires a better understanding of the gaps in the care cascade from TB diagnosis to treatment completion. We sought to assess the child TB care cascade in 32 rural communities in Uganda and Kenya using programmatic data. Methods: This is a retrospective cohort study of 160,851 children (ages <15 years) living in 12 rural communities in Kenya and 22 in Uganda. We reviewed national TB registries from health centers in and adjacent to the 32 communities, and we included all child TB cases recorded from January 1, 2013 to June 30, 2016...
December 2017: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://www.readbyqxmd.com/read/29243109/hiv-pre-exposure-prophylaxis-prep-uptake-and-retention-among-men-who-have-sex-with-men-in-a-community-based-sexual-health-clinic
#10
J Carlo Hojilla, David Vlahov, Pierre-Cedric Crouch, Carol Dawson-Rose, Kellie Freeborn, Adam Carrico
In a community-based clinic serving men who have sex with men in San Francisco, California, this study characterized key steps of the pre-exposure prophylaxis (PrEP) cascade and identified correlates of retention in care. In total, 344 patients were evaluated for PrEP. Three-fourths (78%) of those who sought PrEP services initiated PrEP. The overall cumulative incidence of discontinuing PrEP at 13 months was 38%. Men with a sexually transmitted infection (STI) were 44% less likely to be retained (adjusted hazard ratio [aHR] 0...
December 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29220369/can-mother-to-child-transmission-of-hiv-be-eliminated-without-addressing-the-issue-of-stigma-modeling-the-case-for-a-setting-in-south-africa
#11
Holly J Prudden, Matthew Hamilton, Anna M Foss, Nicole Dzialowy Adams, Melissa Stockton, Vivian Black, Laura Nyblade
BACKGROUND: Stigma and discrimination ontinue to undermine the effectiveness of the HIV response. Despite a growing body of evidence of the negative relationship between stigma and HIV outcomes, there is a paucity of data available on the prevalence of stigma and its impact. We present a probabilistic cascade model to estimate the magnitude of impact stigma has on mother-to-child-transmission (MTCT). METHODS: The model was parameterized using 2010 data from Johannesburg, South Africa, from which loss-to-care at each stage of the antenatal cascade were available...
2017: PloS One
https://www.readbyqxmd.com/read/29210185/redemption-of-the-spoiled-identity-the-role-of-hiv-positive-individuals-in-hiv-care-cascade-interventions
#12
Carol S Camlin, Edwin D Charlebois, Elvin Geng, Fred Semitala, Jeanna Wallenta, Monica Getahun, Leatitia Kampiire, Elizabeth A Bukusi, Norton Sang, Dalsone Kwarisiima, Tamara D Clark, Maya L Petersen, Moses R Kamya, Diane V Havlir
INTRODUCTION: The concept of "therapeutic citizenship" has drawn attention to ways in which public testimony, the "story-telling in the public sphere" undertaken by people living with HIV (PLHIV), has shaped the global response to the epidemic. This paper presents qualitative findings from two large studies in eastern Africa that reveal how the advent of population-based HIV testing campaigns and efforts to accelerate antiretroviral "treatment for all" has precipitated a rapidly expanding therapeutic citizenship "project," or social movement...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29208530/analytical-performances-of-simultaneous-detection-of-hiv-1-hiv-2-and-hepatitis-c-specific-antibodies-and-hepatitis-b-surface-antigen-hbsag-by-multiplex-immunochromatographic-rapid-test-with-serum-samples-a-cross-sectional-study
#13
Leman Robin, Ralph-Sydney Mboumba Bouassa, Zita Aleyo Nodjikouambaye, Laura Charmant, Mathieu Matta, Sylvie Simon, Mounir Filali, Souleymane Mboup, Laurent Bélec
BACKGROUND: The HIV/HCV/HBsAg Triplex consists in manually performed, visually interpreted, lateral flow, immunochromatographic rapid diagnostic test simultaneously detecting in 15min human immunodeficiency virus (HIV)-1 and HIV-2 and hepatitis C virus (HCV)- specific antibodies (Ab) (IgG and IgM) and hepatitis B virus (HBV) surface antigen (HBsAg) in serum, plasma and whole blood. METHODS: A hospital-based cross-sectional study was conducted on a prospective panel of serum samples from adult inpatients included from routine analysis irrespectively of age and sex, including 250 sera positive for HIV-1-specific Ab, 250 for HCV-specific Ab, 250 for HBsAg and 250 sera negative for HIV- and HCV- Ab and HBsAg, and from 110 HIV-2-infected patients living in Ivory Coast, according to the results obtained by the reference chemiluminiscent microparticle immunoassay (CMIA) Abbott Architect i2000SR analyzer (Abbott Diagnostic, Chicago, IL, USA)...
December 5, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29206357/understanding-uptake-of-an-intervention-to-accelerate-antiretroviral-therapy-initiation-in-uganda-via-qualitative-inquiry
#14
Fred C Semitala, Carol S Camlin, Jeanna Wallenta, Leatitia Kampiire, Richard Katuramu, Gideon Amanyire, Jennifer Namusobya, Wei Chang, James G Kahn, Edwin D Charlebois, Diane V Havlir, Moses R Kamya, Elvin H Geng
INTRODUCTION: The Streamlined Antiretroviral Therapy Initiation Strategy (START-ART) study found that a theory-based intervention using opinion leaders to inform and coach health care providers about the risks of treatment delay, provision of point of care (POC) CD4 testing machines (PIMA) and reputational incentives, led to rapid rise in ART initiation. We used qualitative research methods to explore mechanisms of provider behaviour change. METHODS: We conducted in-depth interviews (IDIs) with 24 health care providers and nine study staff to understand perceptions, attitudes and the context of changes in ART initiation practices...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29198185/role-of-substance-use-in-hiv-care-cascade-outcomes-among-people-who-inject-drugs-in-russia
#15
Bulat Idrisov, Karsten Lunze, Debbie M Cheng, Elena Blokhina, Natalia Gnatienko, Emily Quinn, Carly Bridden, Alexander Y Walley, Kendall J Bryant, Dmitry Lioznov, Evgeny Krupitsky, Jeffrey H Samet
BACKGROUND: Engaging people who drink alcohol or inject drugs in HIV care can be challenging, particularly in Eastern Europe. Healthcare facilities in Russia are organized by specialty; therefore linking patients from addiction care to HIV hospitals has been difficult. The HIV care cascade outlines stages of HIV care (e.g., linkage to care, prescribed antiretroviral therapy [ART], and achieving HIV viral suppression). We hypothesized that unhealthy alcohol use, injection drug use, and opioid craving are associated with unfavorable HIV care cascade outcomes...
December 4, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29189416/the-treatment-cascade-in-children-with-unsuppressed-viral-load-a-reality-check-in-rural-lesotho-southern-africa
#16
Thabo Ishmael Lejone, Isaac Ringera, Molisana Cheleboi, Sarah Wagner, Josephine Muhairwe, Thomas Klimkait, Niklaus Daniel Labhardt
BACKGROUND: As per guidelines of the World Health Organization HIV infected children who do not achieve viral suppression while under antiretroviral therapy (ART), receive enhanced adherence counselling (EAC) with follow-up viral load (VL). A persisting unsuppressed VL after EAC triggers switch to a second-line regimen. We describe the care cascade of children with unsuppressed VL while taking ART. METHODS: Children, aged <16 years, on first-line ART for ≥6 months with unsuppressed VL (≥80copies/mL) at first measurement were enrolled...
November 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29189294/using-choice-architecture-to-integrate-substance-use-services-with-primary-care-commentary-on-donohue-et-al-2017
#17
Leo Beletsky
: At a time when death and disability linked to problematic substance use have reached crisis levels, integration of substance use disorder (SUD) services into primary care settings is a clear national priority. Incentive-based interventions can catalyze such adoption, but have thus far demonstrated limited efficaciousness. Behavioral Economics can inform efforts to incentivize healthcare providers to adopt SUD interventions. Choice architecture principles dictate pegging rewards to defined quality metrics, improving provider information about effective and cost-effective practices, and reducing barriers to SUD service provision through technological tools, tackling stigma, and addressing real and perceived regulatory burdens and risks...
November 20, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29185250/management-of-hepatitis-c-in-decentralised-versus-centralised-drug-substitution-programmes-and-minimally-invasive-point-of-care-tests-to-close-gaps-in-the-hcv-cascade
#18
Andrea Bregenzer, Anna Conen, Jürg Knuchel, Andrée Friedl, Franz Eigenmann, Martin Näf, Peter Ackle, Martin Roth, Christoph Andreas Fux
BACKGROUND: In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programmes are often insufficiently screened and treated. AIM: The aim was to compare the current state of HCV management in centralised and decentralised drug substitution programmes of the canton Aargau...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29183868/providing-home-based-hiv-testing-and-counseling-for-transgender-youth-project-moxie-protocol-for-a-pilot-randomized-controlled-trial
#19
Rob Stephenson, Nicholas Metheny, Akshay Sharma, Stephen Sullivan, Erin Riley
BACKGROUND: Transgender and gender nonconforming people experience some of the highest human immunodeficiency virus (HIV) rates in the United States, and experience many structural and behavioral barriers that may limit their engagement in HIV testing, prevention, and care. Evidence suggests that transgender and gender nonconforming youth (TY) are especially vulnerable to acquiring HIV, yet there is little research on TY and few services are targeted towards HIV testing, prevention, and care for this population...
November 28, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29164754/interventions-to-significantly-improve-service-uptake-and-retention-of-hiv-positive-pregnant-women-and-hiv-exposed-infants-along-the-pmtct-continuum-of-care-systematic-review
#20
REVIEW
Alexandra C Vrazo, Jacqueline Firth, Anouk Amzel, Rebecca Sedillo, Julia Ryan, B Ryan Phelps
OBJECTIVES: Despite the success of Prevention of Mother-to-Child Transmission of HIV (PMTCT) programs, low uptake of services and poor retention pose a formidable challenge to achieving the elimination of vertical HIV transmission in low and middle-income countries. This systematic review summarizes interventions that demonstrate statistically significant improvements in service uptake and retention of HIV-positive pregnant and breastfeeding women and their infants along the PMTCT cascade...
November 22, 2017: Tropical Medicine & International Health: TM & IH
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