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Cascade of HIV care

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https://www.readbyqxmd.com/read/28975029/cascade-of-care-among-hiv-patients-diagnosed-in-2013-in-georgia-risk-factors-for-late-diagnosis-and-attrition-from-hiv-care
#1
Ekaterine Ruadze, Nikoloz Chkhartishvili, Otar Chokoshvili, Tengiz Tsertsvadze
INTRODUCTION: The major challenge in the HIV epidemic in Georgia is a high proportion of undiagnosed people living with HIV (estimated 48%) as well as a very high proportion of late presentations for care, with 66% presenting for HIV care with CD4 count <350 and 40% with <200 cells/mm(3), in 2013. The objectives of this study was to evaluate patient engagement in the continuum of HIV care for HIV patients diagnosed in 2013 and, within this cohort, to evaluate factors associated with late diagnosis and attrition from care...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28953326/scaling-a-waterfall-a-meta-ethnography-of-adolescent-progression-through-the-stages-of-hiv-care-in-sub-saharan-africa
#2
Shannon Williams, Jenny Renju, Ludovica Ghilardi, Alison Wringe
INTRODUCTION: Observational studies have shown considerable attrition among adolescents living with HIV across the "cascade" of HIV care in sub-Saharan Africa, leading to higher mortality rates compared to HIV-infected adults or children. We synthesized evidence from qualitative studies on factors that promote or undermine engagement with HIV services among adolescents living with HIV in sub-Saharan Africa. METHODS: We systematically searched five databases for studies published between 2005 and 2016 that met pre-defined inclusion criteria...
September 15, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953323/hiv-testing-and-the-care-continuum-among-transgender-women-population-estimates-from-rio-de-janeiro-brazil
#3
Emilia M Jalil, Erin C Wilson, Paula M Luz, Luciane Velasque, Ronaldo I Moreira, Cristiane V Castro, Laylla Monteiro, Ana Cristina F Garcia, Sandra W Cardoso, Lara E Coelho, Willi McFarland, Albert Y Liu, Valdilea G Veloso, Susan Buchbinder, Beatriz Grinsztejn
INTRODUCTION: Evidence suggests that, of all affected populations, transgender women (transwomen) may have the heaviest HIV burden worldwide. Little is known about HIV linkage and care outcomes for transwomen. We aimed to estimate population-level indicators of the HIV cascade of care continuum, and to evaluate factors associated with viral suppression among transwomen in Rio de Janeiro, Brazil. METHODS: We conducted a respondent-driven sampling (RDS) study of transwomen from August 2015 to January 2016 in Rio de Janeiro, Brazil and collected data on linkage and access to care, antiretroviral treatment and performed HIV viral load testing...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28953322/a-historical-review-of-hiv-prevention-and-care-initiatives-in-british-columbia-canada-1996-2015
#4
Michelle Olding, Ben Enns, Dimitra Panagiotoglou, Jean Shoveller, P Richard Harrigan, Rolando Barrios, Thomas Kerr, Julio S G Montaner, Bohdan Nosyk
INTRODUCTION: British Columbia has made significant progress in the treatment and prevention of HIV since 1996, when Highly Active Antiretroviral Therapy (HAART) became available. However, we currently lack a historical summary of HIV prevention and care interventions implemented in the province since the introduction of HAART and how they have shaped the HIV epidemic. Guided by a socio-ecological framework, we present a historical review of biomedical and health services, community and structural interventions implemented in British Columbia from 1996-2015 to prevent HIV transmission or otherwise enhance the cascade of HIV care...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28886165/low-mother-to-child-hiv-transmission-rate-but-high-loss-to-follow-up-among-mothers-and-babies-in-mandalay-myanmar-a-cohort-study
#5
Khine Wut Yee Kyaw, Myo Minn Oo, Nang Thu Thu Kyaw, Khaing Hnin Phyo, Thet Ko Aung, Theingi Mya, Nilar Aung, Htun Nyunt Oo, Petros Isaakidis
INTRODUCTION: Loss-to-follow-up (LTFU) throughout the Prevention of Mother-To-Child Transmission (PMTCT) cascade remains one of the major threats to the success of PMTCT programs. In this study, we aimed to determine the mother-to-child transmission rate in a programmatic setting and to determine factors associated with LTFU among enrolled mothers and unfavorable outcomes among HIV-exposed babies which includes being HIV positive, death and LTFU. METHODS: A retrospective cohort study reviewing routinely collected data in an Integrated HIV care program, Mandalay, Myanmar in June 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28880486/out-of-focus-tailoring-the-cascade-of-care-to-the-needs-of-women-living-with-hiv
#6
REVIEW
A M Geretti, M Loutfy, A D'Arminio Monforte, I Latysheva, M J Pérez Elías, J Rymer, M Boffito
Around half of the global adult HIV-positive population are women, yet historically women have been under-represented in clinical studies of antiretroviral therapy (ART) and there has been minimal exploration of gender-specific factors related to the response to and appropriateness of treatment choices in women living with HIV (WLWH). There are several key issues pertaining to the cascade of HIV care that make it important to differentiate WLWH from men living with HIV. Factors that are gender specific may impact on the status of WLWH, affecting access to diagnosis and treatment, optimal clinical management, ART outcomes, retention in care, and the overall long-term wellbeing of WLWH...
September 2017: HIV Medicine
https://www.readbyqxmd.com/read/28870282/transgender-women-and-hiv-related-health-disparities-falling-off-the-hiv-treatment-cascade
#7
Seth C Kalichman, Dominica Hernandez, Stephanie Finneran, Devon Price, Redd Driver
Background: Transgender women living with HIV infection experience poorer health outcomes across the HIV continuum of care. While disparities are well established, their underlying mechanisms are not well understood. This study examined the HIV continuum of care (also known as the HIV treatment cascade), including linkage and engagement in care and health status among transgender women and cisgender women and cisgender men living with HIV. Method: Case-control matching was applied to a cohort of 1101 people living with HIV; 70 transgender women living with HIV were matched on years since testing HIV positive with cisgender women and cisgender men...
September 5, 2017: Sexual Health
https://www.readbyqxmd.com/read/28870232/hiv-treatment-cascade-among-female-entertainment-and-sex-workers-in-cambodia-impact-of-amphetamine-use-and-an-hiv-prevention-program
#8
Sokunny Muth, Aynar Len, Jennifer L Evans, Maly Phou, Sophal Chhit, Yuthea Neak, Song Ngak, Ellen S Stein, Adam W Carrico, Lisa Maher, Kimberly Page
BACKGROUND: HIV prevalence remains high in Cambodia among female entertainment and sex workers (FESW), and amphetamine-type stimulant (ATS) use significantly increases risk of infection. A successful continuum of care (CoC) is key to effective clinical care and prevention. This study aimed to describe the HIV CoC in HIV-positive FESW. We examined CoC outcomes among HIV-positive FESW participating in the Cambodia Integrated HIV and Drug Prevention Implementation (CIPI) study, being implemented in ten provinces...
September 5, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28867267/testing-and-linkage-to-hiv-care-in-china-a-cluster-randomised-trial
#9
Zunyou Wu, Zhenzhu Tang, Yurong Mao, Paul Van Veldhuisen, Walter Ling, David Liu, Zhiyong Shen, Roger Detels, Guanghua Lan, Lynda Erinoff, Robert Lindblad, Diane Gu, Houlin Tang, Lian Hu, Qiuying Zhu, Li Lu, Neal Oden, Albert L Hasson, Yan Zhao, Jennifer M McGoogan, Xianmin Ge, Nanci Zhang, Keming Rou, Jinhui Zhu, Hui Wei, Cynthia X Shi, Xia Jin, Jian Li, Julio S G Montaner
BACKGROUND: Multistage, stepwise HIV testing and treatment procedures can result in lost opportunities to provide timely antiretroviral therapy (ART). Incomplete engagement of patients along the care cascade translates into high preventable mortality. We aimed to identify whether a structural intervention to streamline testing and linkage to HIV health care would improve testing completeness, ART initiation, and viral suppression and reduce mortality. METHODS: We did a cluster-randomised, controlled trial in 12 hospitals in Guangxi, China...
August 31, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28855397/inflammatory-monocytes-expressing-tissue-factor-drive-siv-and-hiv-coagulopathy
#10
Melissa E Schechter, Bruno B Andrade, Tianyu He, George Haret Richter, Kevin W Tosh, Benjamin B Policicchio, Amrit Singh, Kevin D Raehtz, Virginia Sheikh, Dongying Ma, Egidio Brocca-Cofano, Cristian Apetrei, Russel Tracy, Ruy M Ribeiro, Alan Sher, Ivo M B Francischetti, Ivona Pandrea, Irini Sereti
In HIV infection, persistent inflammation despite effective antiretroviral therapy is linked to increased risk of noninfectious chronic complications such as cardiovascular and thromboembolic disease. A better understanding of inflammatory and coagulation pathways in HIV infection is needed to optimize clinical care. Markers of monocyte activation and coagulation independently predict morbidity and mortality associated with non-AIDS events. We identified a specific subset of monocytes that express tissue factor (TF), persist after virological suppression, and trigger the coagulation cascade by activating factor X...
August 30, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28841910/the-hiv-care-cascade-from-hiv-diagnosis-to-viral-suppression-in-sub-saharan-africa-a-systematic-review-and-meta-regression-analysis-protocol
#11
Aysel Gueler, Fiona Vanobberghen, Brian Rice, Matthias Egger, Catrina Mugglin
BACKGROUND: In 2014, UNAIDS announced the 90-90-90 treatment targets to curb the HIV epidemic by 2020: 90% of people living with HIV know their HIV status, 90% of people who know their HIV status access treatment and 90% of people on treatment have suppressed viral loads. Monitoring and evaluation are needed to track linkage and retention throughout the continuum of care. We propose a systematic review and meta-regression to identify the different methodological approaches used to define the steps in the HIV care cascade in sub-Saharan Africa (SSA), where most people with HIV live, and to assess the proportion of participants retained at each step...
August 25, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28797022/evaluation-of-the-isoniazid-preventive-therapy-care-cascade-among-hiv-positive-female-sex-workers-in-mombasa-kenya
#12
Sylvia M LaCourse, Ruth W Deya, Susan M Graham, Linnet N Masese, Walter Jaoko, Kischorchandra N Mandaliya, Julie Overbaugh, R Scott McClelland
BACKGROUND: Kenyan female sex workers (FSWs) have a high HIV prevalence, increasing their tuberculosis (TB) risk. Despite recommendations that HIV-positive individuals be offered isoniazid preventive therapy (IPT), uptake has been limited. METHODS: In this longitudinal cohort of HIV-positive FSWs, we retrospectively characterized the IPT care cascade between March 2000 and January 2010, including reasons for cascade loss or appropriate exit. Cascade success required completion of 6 months of IPT...
September 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28791915/assessing-the-feasibility-of-smartphone-apps-for-hiv-care-research-with-msm-and-transgender-individuals-in-mpumalanga-south-africa
#13
Joseph Daniels, Tim Lane, Helen Struthers, Kabelo Maleke, Winta Moges, James McIntyre, Thomas Coates
There is an urgent need to develop the HIV treatment cascade for men who have sex with men (MSM) and transgender individuals in rural Mpumalanga, South Africa. Mhealth tools such as smartphone applications have the potential to support HIV self-care behaviors. We conducted an exploratory study with HIV-positive community leaders to understand their current uses of cell phones and smartphones and to assess their interest in an HIV research study that utilized a smartphone application for HIV care support. A total of 18 community leaders were recruited to complete a questionnaire and focus group...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28777506/when-patients-fail-unaids-last-90-the-failure-cascade-beyond-90-90-90-in-rural-lesotho-southern-africa-a-prospective-cohort-study
#14
Niklaus Daniel Labhardt, Isaac Ringera, Thabo Ishmael Lejone, Molisana Cheleboi, Sarah Wagner, Josephine Muhairwe, Thomas Klimkait
INTRODUCTION: HIV-infected individuals on first-line antiretroviral therapy (ART) in resource-limited settings who do not achieve the last "90" (viral suppression) enter a complex care cascade: enhanced adherence counselling (EAC), repetition of viral load (VL) and switch to second-line ART aiming to achieve resuppression. This study describes the "failure cascade" in patients in Lesotho. METHODS: Patients aged ≥16 years on first-line ART at 10 facilities in rural Lesotho received a first-time VL in June 2014...
July 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28747999/human-immunodeficiency-virus-care-cascade-among-sub-populations-in-rakai-uganda-an-observational-study
#15
Veena G Billioux, Larry W Chang, Steven J Reynolds, Gertrude Nakigozi, Joseph Ssekasanvu, Mary K Grabowski, Robert Ssekubugu, Fred Nalugoda, Godfrey Kigozi, Joseph Kagaayi, David Serwadda, Ronald H Gray, Maria J Wawer
Introduction: To assess progress towards the UNAIDS 90-90-90 initiative targets, we examined the HIV care cascade in the population-based Rakai Community Cohort Study (RCCS) in rural Uganda and examined differences between sub-groups. Methods: Self-reports and clinical records were used to assess the proportion achieving each stage in the cascade. Statistical inference based on a χ(2) test for categorical variables and modified Poisson regression were used to estimate prevalence risk ratios (PRRs) and 95% confidence intervals (CI) for enrolment into care and initiating antiretroviral therapy (ART)...
2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28736393/traditional-healers-faith-healers-and-medical-practitioners-the-contribution-of-medical-pluralism-to-bottlenecks-along-the-cascade-of-care-for-hiv-aids-in-eastern-and-southern-africa
#16
Mosa Moshabela, Dominic Bukenya, Gabriel Darong, Joyce Wamoyi, Estelle McLean, Morten Skovdal, William Ddaaki, Kenneth Ondeng'e, Oliver Bonnington, Janet Seeley, Victoria Hosegood, Alison Wringe
OBJECTIVES: There are concerns that medical pluralism may delay patients' progression through the HIV cascade-of-care. However, the pathways of impact through which medical pluralism influence the care of people living with HIV (PLHIV) in African settings remain unclear. We sought to establish the manifestation of medical pluralism among PLHIV, and explore mechanisms through which medical pluralism contributes bottlenecks along the HIV care cascade. METHODS: We conducted a multicountry exploratory qualitative study in seven health and demographic surveillance sites in six eastern and southern African countries: Uganda, Kenya, Tanzania, Malawi, Zimbabwe and South Africa...
July 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28729520/challenges-and-emerging-opportunities-for-the-hiv-prevention-treatment-and-care-cascade-in-men-who-have-sex-with-men-in-asia-pacific
#17
REVIEW
Frits van Griensven, Thomas E Guadamuz, Jan Willem de Lind van Wijngaarden, Nittaya Phanuphak, Sunil Suhas Solomon, Ying-Ru Lo
In Asia Pacific, most countries have expanded HIV treatment guidelines to include all those with HIV infection and adopted antiretroviral treatment for prevention (TFP) as a blanket strategy for HIV control. Although the overall epidemic development associated with this focus is positive, the HIV epidemic in men who have sex with men (MSM) is continuing unperturbed without any signs of decline or reversal. This raises doubt about whether TFP as a blanket HIV prevention policy is the right approach. This paper reviews currently available biomedical HIV prevention strategies, national HIV prevention policies and guidelines from selected countries and published data on the HIV cascade in MSM...
August 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28718494/the-hiv-care-cascade-in-buenos-aires-argentina-results-in-a-tertiary-referral-hospital
#18
Carina Cesar, Gabriela Blugerman, José Antonio Valiente, Peter Rebeiro, Omar Sued, Valeria Fink, Mariana Romero Soto, Roberto Cillis, Cleyton Yamamoto, Carlos Falistocco, Pedro Cahn, Héctor Pérez
Objective: To determine rates of retention, antiretroviral therapy (ART) use, and viral suppression in an adult cohort from a public tertiary referral hospital in the city of Buenos Aires, Argentina. Methods: HIV-positive ART-naïve patients ≥ 18 years old starting care 2011-2013 contributed data until the end of 2014. Three outcomes were assessed in 2014: retention in care, ART use, and viral suppression. Patient characteristics associated with each outcome were assessed through logistic regression...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28718493/the-hiv-continuum-of-care-in-the-bahamas-in-2014
#19
Nikkiah Forbes, Glenise Johnson, Arvis Mortimer, Indira Martin, Morton Frankson, Kathryn Johnston, Tamara Thompson, Sharon Weissman
Objective: The HIV cascade of care describes the spectrum of engagement in HIV care from diagnosis to viral suppression (VS). The study objective was to develop a baseline HIV cascade of care for new HIV diagnoses in the Bahamas in 2014. Methods: Individuals who were newly diagnosed with HIV in 2014 and known to be alive within a year of that diagnosis were included in the cascade of care (n = 250). Individuals with one CD4 or HIV viral load (VL) measure in 2014 were considered linked to care...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28715986/the-hiv-care-cascade-among-individuals-under-community-supervision-in-baltimore-maryland
#20
Nickolas Zaller, Michael Gordon, Lauri Bazerman, Irene Kuo, Curt Beckwith
An estimated one in seven HIV-infected individuals pass through U.S. correctional facilities each year. Transitioning from correctional to community settings may increase HIV treatment interruptions and increase the risk of continued HIV transmission in the community. This study assessed access to HIV providers in the community, antiretroviral treatment, and viral suppression to inform the development of interventions to improve HIV treatment outcomes among individuals involved in community corrections. The sample included 100 individuals under community supervision (probation or parole) in Baltimore, Maryland...
July 2017: Journal of Correctional Health Care
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