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https://www.readbyqxmd.com/read/28617387/-pharmacological-neuroprotection-in-stroke-in-clinical-practice-new-perspectives
#1
D V Sergeev, M A Domashenko, M A Piradov
Despite recent advances in acute stroke care, clinical armamentarium against stroke remains limited. Furthermore, highly effective approaches to stroke treatment, such as systemic reperfusion and mechanical thrombectomy, cannot be performed in the majority of patients. Neuroprotective strategies, i.e. prevention of irreversible cell damage due to the ischemia, may improve stroke outcomes. However, only few pharmacological agents demonstrated clinical efficacy. Citicoline is an endogenous mononucleotide with neuroprotective effect and established clinical safety and tolerability, which effectiveness in acute stroke was studied in several large, well-controlled trials...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28573143/combination-of-neuroprotective-and-regenerative-agents-for-age-induced-retinal-degeneration-in-vitro-study
#2
Guzel Bikbova, Toshiyuki Oshitari, Takayuki Baba, Shuichi Yamamoto
To determine the most effective combination of neuroprotective and regenerative agents for cultured retinal neurons from advanced glycation end products- (AGEs-) induced degeneration, retinal explants of 7 adult Sprague-Dawley rats were three-dimensionally cultured in collagen gel and incubated in serum-free media and in 7 media; namely, AGEs, AGEs + 100 μM citicoline, AGEs + 10 ng/mL NT-4, AGEs + 100 μM TUDCA, AGEs + 100 μM citicoline + TUDCA (doublet), and AGEs + 100 μM citicoline + TUDCA + 10 ng/mL NT-4 (triplet) were examined...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28458415/is-aura-around-citicoline-fading-a-systemic-review
#3
Saurabh Agarwal, Bhoomika M Patel
Stroke and traumatic brain injury (TBI) are the critical public health and socioeconomic problems throughout the world. At present, citicoline is used as a coadjuvant for the management of acute ischemic stroke (AIS) and TBI in various countries. This systemic review analyzes the beneficial role of citicoline in AIS and TBI. This systemic review is based on "PubMed" and "Science Direct" search results for citicoline role in stroke and TBI. In this systemic review, we included 12 human trials. A meta-analysis was performed on the basis of neurological evaluation, functional evaluation and Glasgow outcome scale, domestic adaptation evaluation outcomes, and cognitive outcome individually...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28440093/turmeric-curcuma-longa-l-extract-may-prevent-the-deterioration-of-spatial-memory-and-the-deficit-of-estimated-total-number-of-hippocampal-pyramidal-cells-of-trimethyltin-exposed-rats
#4
Sapto Yuliani, Mustofa, Ginus Partadiredja
CONTEXT: Protection of neurons from degeneration is an important preventive strategy for dementia. Much of the dementia pathology implicates oxidative stress pathways. Turmeric (Curcuma longa L.) contains curcuminoids which has anti-oxidative and neuro-protective effects. These effects are considered to be similar to those of citicoline which has been regularly used as one of standard medications for dementia. OBJECTIVE: This study aimed at investigating the effects of turmeric rhizome extract on the hippocampus of trimethyltin (TMT)-treated Sprague-Dawley rats...
April 25, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28417449/citicoline-pharmacological-and-clinical-review-2016-update
#5
REVIEW
J J Secades
This review is based on the previous one published in 2010 -Secades JJ. Citicoline: pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62-, incorporating 183 new references, having all the information available to facilitate the access to the information in one document. This review is focused on the main indications of the drug, as acute stroke and its sequelae, including the cognitive impairment, and traumatic brain injury and its sequelae. There are retrieved the most important experimental and clinical data in both indications...
December 23, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/28366066/neuroprotective-strategies-and-the-underlying-molecular-basis-of-cerebrovascular-stroke
#6
REVIEW
Michael Karsy, Andrea Brock, Jian Guan, Phillip Taussky, M Yashar S Kalani, Min S Park
Stroke is a leading cause of disability in the US. Although there has been significant progress in the area of medical and surgical thrombolytic technologies, neuroprotective agents to prevent secondary cerebral injury and to minimize disability remain limited. Only limited success has been reported in preclinical and clinical trials evaluating a variety of compounds. In this review, the authors discuss the most up-to-date information regarding the underlying molecular biology of stroke as well as strategies that aim to mitigate this complex signaling cascade...
April 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28319408/turmeric-extract-inhibits-apoptosis-of-hippocampal-neurons-of-trimethyltin-exposed-rats
#7
S Yuliani, S Widyarini, Mustofa, G Partadiredja
OBJECTIVES: The aim of the present study was to reveal the possible antiapoptotic effect of turmeric (Curcuma longa Linn.) on the hippocampal neurons of rats exposed to trimethyltin (TMT). BACKGROUND: Oxidative damage in the hippocampus can induce the apoptosis of neurons associated with the pathogenesis of dementiaMETHODS. The ethanolic turmeric extract and a citicoline (as positive control) solution were administered to the TMT-exposed rats for 28 days. The body weights of rats were recorded once a week...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28301219/management-of-comorbid-bipolar-disorder-and-substance-use-disorders
#8
Ihsan M Salloum, Edson Sherwood Brown
BACKGROUND: The comorbidity of substance use disorders (SUDs) in bipolar disorder is among the highest in psychiatric disorders. Evidence-based controlled psychosocial or pharmacological interventions trials, which may guide treatment decisions, have not been systematically reviewed. OBJECTIVE: To present a narrative review of the public health and clinical significance of this condition, including diagnostic and treatment implications, and to evaluate controlled trials conducted to date...
July 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28121935/effects-of-citicoline-therapy-on-the-network-connectivity-of-the-corpus-callosum-in-patients-with-leukoaraiosis
#9
Liang Feng, Hong Jiang, Yunxia Li, Fei Teng, Yusheng He
This study aimed to investigate the effects of citicoline therapy on the network connectivity of the corpus callosum in patients with leukoaraiosis (LA) by diffusion tension imaging (DTI).A total of 30 LA patients with Fazekas score of 2 to 3 were voluntarily assigned into citicoline group (n = 14) and control group (n = 16). In citicoline group, citicoline was administered at 0.6 g/d for 1 year. In control group, central nervous system drugs should not be used, except for sleeping pills and antidepressants...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28039682/citicoline-for-traumatic-brain-injury-a-systematic-review-meta-analysis
#10
Ali Meshkini, Mohammad Meshkini, Homayoun Sadeghi-Bazargani
BACKGROUND: Traumatic Brain Injury (TBI) is the leading cause of mortality and morbidity especially in young ages. Despite over 30 years of using Neuroprotective agents for TBI management, there is no absolute recommended agent for the condition yet. METHODS: This study is a part of a scoping review thesis on "Neuroprotective agents using for Traumatic Brain Injury: a systematic review & meta-analyses", which had a wide proposal keywords and ran in "Cochrane CENTRAL", "MedLine/PubMed", "SCOPUS", "Thomson Reuters Web of Science", "SID...
January 1, 2017: Journal of Injury & Violence Research
https://www.readbyqxmd.com/read/28035929/the-citicholinage-study-citicoline-plus-cholinesterase-inhibitors-in-aged-patients-affected-with-alzheimer-s-disease-study
#11
Pietro Gareri, Alberto Castagna, Antonino Maria Cotroneo, Daria Putignano, Raffaele Conforti, Francesco Santamaria, Saverio Marino, Salvatore Putignano
BACKGROUND: Citicoline can have beneficial effects both in degenerative and in vascular cognitive decline in a variety of ways (apoptosis inhibition, neuroplasticity potentiation, phospholipid, and acetylcholine (ACh) synthesis). Acetylcholinesterase inhibitors (AChEIs) have been used for treatment of Alzheimer's disease (AD). When co-administered with cholinergic precursors, they are able to increase the intrasynaptic levels of ACh more than when the single drugs given alone. OBJECTIVE: The aim of the present study was to show the effectiveness of oral citicoline plus AChEIs in patients affected with AD...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27769579/molecular-structure-and-differential-function-of-choline-kinases-chk%C3%AE-and-chk%C3%AE-in-musculoskeletal-system-and-cancer
#12
REVIEW
Xi Chen, Heng Qiu, Chao Wang, Yu Yuan, Jennifer Tickner, Jiake Xu, Jun Zou
Choline, a hydrophilic cation, has versatile physiological roles throughout the body, including cholinergic neurotransmission, memory consolidation and membrane biosynthesis and metabolism. Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). PC is a major constituent of the phospholipid bilayer which constitutes the eukaryotic cell membrane, and regulates cell signal transduction...
February 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27587069/the-citirivad-study-citicoline-plus-rivastigmine-in-elderly-patients-affected-with-dementia-study
#13
Alberto Castagna, Antonino Maria Cotroneo, Giovanni Ruotolo, Pietro Gareri
BACKGROUND: Acetylcholinesterase inhibitors (AchEIs), such as rivastigmine, coadministered with cholinergic precursors, such as citicoline, could be effective in Alzheimer's disease (AD) and in mixed dementia (MD), because they are able to increase the intrasynaptic levels of acetylcholine more than the single drugs given alone. OBJECTIVE: The aim of the present study was to show the effectiveness of oral citicoline plus rivastigmine in patients with AD and MD. METHODS: The CITIRIVAD study was a retrospective case-control study on 174 consecutive outpatients aged ≥65 years, affected with AD or MD, mean age 81...
December 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27581256/commentary-citicoline-a-food-beneficial-for-patients-suffering-from-or-threated-with-glaucoma
#14
COMMENT
Vincenzo Parisi, Lucia Ziccardi, Gloria Roberti, Lucia Tanga, Gianluca Manni
No abstract text is available yet for this article.
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27539610/a-meta-analysis-of-the-effect-of-different-neuroprotective-drugs-in-management-of-patients-with-traumatic-brain-injury
#15
REVIEW
Iman El Sayed, Adel Zaki, Akram M Fayed, Gihan M Shehata, Sherif Abdelmonem
Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients. Comprehensive search of electronic databases, search engines, and conferences proceedings; hand search journals; searching reference lists of relevant articles, theses, and local publications; and contact of authors for incomplete data were performed...
August 18, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27475676/evaluation-of-neuroprotective-anticonvulsant-sedative-and-anxiolytic-activity-of-citicoline-in-rats
#16
Arash Abdolmaleki, Ali Moghimi, Mohammad B Ghayour, Morteza B Rassouli
Citicoline (cytidine-5'-diphosphocholine) is a neuroprotective agent that is administered following ischemic and traumatic brain injuries. There is little information about the antiseizure and anxiolytic effects of citicoline, which are therefore addressed in the present study. For evaluating the anticonvulsant effect of citicoline in the pentylentetrazole seizure model, a single intraperitoneal dose of citicoline was administered at 50, 100 or 150mg/kg. Sedative and anxiolytic effects of citicoline were examined via elevated plus maze and pentobarbital induced sleep tests...
October 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27446492/label-free-cest-mri-detection-of-citicoline-liposome-drug-delivery-in-ischemic-stroke
#17
Huanling Liu, Anna Jablonska, Yuguo Li, Suyi Cao, Dexiang Liu, Hanwei Chen, Peter Cm Van Zijl, Jeff W M Bulte, Miroslaw Janowski, Piotr Walczak, Guanshu Liu
ABSTRACT Citicoline (CDPC) is a natural supplement with well-documented neuroprotective effects in the treatment of neurodegenerative diseases. In the present study, we sought to exploit citicoline as a theranostic agent with its inherent chemical exchange saturation transfer (CEST) MRI signal, which can be directly used as an MRI guidance in the citicoline drug delivery. Our in vitro CEST MRI results showed citicoline has two inherent CEST signals at +1 and +2 ppm, attributed to exchangeable hydroxyl and amine protons, respectively...
2016: Theranostics
https://www.readbyqxmd.com/read/27284264/cytidine-5-diphosphocholine-administration-prevents-peripheral-neuropathic-pain-after-sciatic-nerve-crush-injury-in-rats
#18
Dessy R Emril, Samekto Wibowo, Lucas Meliala, Rina Susilowati
BACKGROUND: Cytidine 5'-diphosphocholine (citicoline) has been shown to have beneficial effects in central nervous system injury as well as in motoric functional recovery after peripheral nerve injury. This study aimed to examine the effect of citicoline on prevention of neuropathic pain in a rat model of sciatic nerve crush injury. METHODS: Forty experimental rats were divided into four groups. In three groups, the right sciatic nerves were crushed in the mid-thigh region, and a gelatin sponge moistened with 0...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27234918/citicoline-for-acute-ischemic-stroke-a-systematic-review-and-formal-meta-analysis-of-randomized-double-blind-and-placebo-controlled-trials
#19
REVIEW
Julio J Secades, José Alvarez-Sabín, José Castillo, Exuperio Díez-Tejedor, Eduardo Martínez-Vila, José Ríos, Natalia Oudovenko
BACKGROUND: Citicoline is a drug approved for the treatment of acute ischemic stroke. Although evidence of its efficacy has been reported, recently published results of a large placebo-controlled clinical trial did not show differences. This study aims to assess whether starting citicoline treatment within 14 days after stroke onset improves the outcome in patients with acute ischemic stroke, as compared with placebo. METHODS: A systematic search was performed to identify all published, unconfounded, randomized, double-blind, and placebo-controlled clinical trials of citicoline in acute ischemic stroke...
August 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27178312/protective-effect-of-citicoline-against-aluminum-induced-cognitive-impairments-in-rats
#20
Ahmed O Abdel-Zaher, Mostafa M Hamdy, Mahran S Abdel-Rahman, Doaa H Abd El-Hamid
The potential protective effect of citicoline on aluminum chloride-induced cognitive deficits was investigated in rats. In a Morris water maze, administration of aluminum chloride to rats for 90 days resulted in increased escape latency to reach the platform and decreased swimming speed in acquisition trials. Similarly, in probe trials, the time required to reach the hidden platform was increased and the time spent in the target quadrant was reduced. Also, administration of aluminum chloride to rats for 90 days increased the reference and working memory errors and time required to end the task in the radial arm maze...
April 2017: Toxicology and Industrial Health
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