keyword
MENU ▼
Read by QxMD icon Read
search

Citicoline

keyword
https://www.readbyqxmd.com/read/27769579/molecular-structure-and-differential-function-of-choline-kinases-chk%C3%AE-and-chk%C3%AE-in-musculoskeletal-system-and-cancer
#1
Xi Chen, Heng Qiu, Chao Wang, Yu Yuan, Jennifer Tickner, Jiake Xu, Jun Zou
Choline, a hydrophilic cation, has versatile physiological roles throughout the body, including cholinergic neurotransmission, memory consolidation and membrane biosynthesis and metabolism. Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). PC is a major constituent of the phospholipid bilayer which constitutes the eukaryotic cell membrane, and regulates cell signal transduction...
October 8, 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27587069/the-citirivad-study-citicoline-plus-rivastigmine-in-elderly-patients-affected-with-dementia-study
#2
Alberto Castagna, Antonino Maria Cotroneo, Giovanni Ruotolo, Pietro Gareri
BACKGROUND: Acetylcholinesterase inhibitors (AchEIs), such as rivastigmine, coadministered with cholinergic precursors, such as citicoline, could be effective in Alzheimer's disease (AD) and in mixed dementia (MD), because they are able to increase the intrasynaptic levels of acetylcholine more than the single drugs given alone. OBJECTIVE: The aim of the present study was to show the effectiveness of oral citicoline plus rivastigmine in patients with AD and MD. METHODS: The CITIRIVAD study was a retrospective case-control study on 174 consecutive outpatients aged ≥65 years, affected with AD or MD, mean age 81...
September 1, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27581256/commentary-citicoline-a-food-beneficial-for-patients-suffering-from-or-threated-with-glaucoma
#3
COMMENT
Vincenzo Parisi, Lucia Ziccardi, Gloria Roberti, Lucia Tanga, Gianluca Manni
No abstract text is available yet for this article.
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27539610/a-meta-analysis-of-the-effect-of-different-neuroprotective-drugs-in-management-of-patients-with-traumatic-brain-injury
#4
Iman El Sayed, Adel Zaki, Akram M Fayed, Gihan M Shehata, Sherif Abdelmonem
Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients. Comprehensive search of electronic databases, search engines, and conferences proceedings; hand search journals; searching reference lists of relevant articles, theses, and local publications; and contact of authors for incomplete data were performed...
August 18, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27475676/evaluation-of-neuroprotective-anticonvulsant-sedative-and-anxiolytic-activity-of-citicoline-in-rats
#5
Arash Abdolmaleki, Ali Moghimi, Mohammad B Ghayour, Morteza B Rassouli
Citicoline (cytidine-5'-diphosphocholine) is a neuroprotective agent that is administered following ischemic and traumatic brain injuries. There is little information about the antiseizure and anxiolytic effects of citicoline, which are therefore addressed in the present study. For evaluating the anticonvulsant effect of citicoline in the pentylentetrazole seizure model, a single intraperitoneal dose of citicoline was administered at 50, 100 or 150mg/kg. Sedative and anxiolytic effects of citicoline were examined via elevated plus maze and pentobarbital induced sleep tests...
October 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27446492/label-free-cest-mri-detection-of-citicoline-liposome-drug-delivery-in-ischemic-stroke
#6
Huanling Liu, Anna Jablonska, Yuguo Li, Suyi Cao, Dexiang Liu, Hanwei Chen, Peter Cm Van Zijl, Jeff W M Bulte, Miroslaw Janowski, Piotr Walczak, Guanshu Liu
ABSTRACT Citicoline (CDPC) is a natural supplement with well-documented neuroprotective effects in the treatment of neurodegenerative diseases. In the present study, we sought to exploit citicoline as a theranostic agent with its inherent chemical exchange saturation transfer (CEST) MRI signal, which can be directly used as an MRI guidance in the citicoline drug delivery. Our in vitro CEST MRI results showed citicoline has two inherent CEST signals at +1 and +2 ppm, attributed to exchangeable hydroxyl and amine protons, respectively...
2016: Theranostics
https://www.readbyqxmd.com/read/27284264/cytidine-5-diphosphocholine-administration-prevents-peripheral-neuropathic-pain-after-sciatic-nerve-crush-injury-in-rats
#7
Dessy R Emril, Samekto Wibowo, Lucas Meliala, Rina Susilowati
BACKGROUND: Cytidine 5'-diphosphocholine (citicoline) has been shown to have beneficial effects in central nervous system injury as well as in motoric functional recovery after peripheral nerve injury. This study aimed to examine the effect of citicoline on prevention of neuropathic pain in a rat model of sciatic nerve crush injury. METHODS: Forty experimental rats were divided into four groups. In three groups, the right sciatic nerves were crushed in the mid-thigh region, and a gelatin sponge moistened with 0...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27234918/citicoline-for-acute-ischemic-stroke-a-systematic-review-and-formal-meta-analysis-of-randomized-double-blind-and-placebo-controlled-trials
#8
Julio J Secades, José Alvarez-Sabín, José Castillo, Exuperio Díez-Tejedor, Eduardo Martínez-Vila, José Ríos, Natalia Oudovenko
BACKGROUND: Citicoline is a drug approved for the treatment of acute ischemic stroke. Although evidence of its efficacy has been reported, recently published results of a large placebo-controlled clinical trial did not show differences. This study aims to assess whether starting citicoline treatment within 14 days after stroke onset improves the outcome in patients with acute ischemic stroke, as compared with placebo. METHODS: A systematic search was performed to identify all published, unconfounded, randomized, double-blind, and placebo-controlled clinical trials of citicoline in acute ischemic stroke...
August 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27178312/protective-effect-of-citicoline-against-aluminum-induced-cognitive-impairments-in-rats
#9
Ahmed O Abdel-Zaher, Mostafa M Hamdy, Mahran S Abdel-Rahman, Doaa H Abd El-Hamid
The potential protective effect of citicoline on aluminum chloride-induced cognitive deficits was investigated in rats. In a Morris water maze, administration of aluminum chloride to rats for 90 days resulted in increased escape latency to reach the platform and decreased swimming speed in acquisition trials. Similarly, in probe trials, the time required to reach the hidden platform was increased and the time spent in the target quadrant was reduced. Also, administration of aluminum chloride to rats for 90 days increased the reference and working memory errors and time required to end the task in the radial arm maze...
May 13, 2016: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/27092075/citicoline-a-food-beneficial-for-patients-suffering-from-or-threated-with-glaucoma
#10
REVIEW
Pawel Grieb, Anselm Jünemann, Marek Rekas, Robert Rejdak
Oral form of citicoline, a nootropic and neuroprotective drug in use for almost five decades, recently was pronounced a food supplement in both USA and EU. The idea of adding citicoline to topical treatment of primary open angle glaucoma (POAG) aimed at decreasing intraocular pressure (IOP) appeared as a logical consequence of accepting neurodegenerative character of this disease. Experimental data, and also few clinical studies indicate that this substance has potential to counteract some important pathological mechanisms which seem to contribute to POAG initiation and progression, such as excitotoxicity and oxidative stress...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27072975/early-application-of-citicoline-in-the-treatment-of-acute-stroke-a-meta-analysis-of-randomized-controlled-trials
#11
Pei-yu Shi, Xiao-cui Zhou, Xiao-xue Yin, Liang-liang Xu, Xing-ming Zhang, Hong-ying Bai
This study was to evaluate the efficacy and safety of early application of citicoline in the treatment of patients with acute stroke by meta-analysis. Randomized controlled trials published until May 2015 were electronically searched in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, and China Biology Medicine disc. Two reviewers independently screened the articles and extracted the data based on the inclusion and exclusion criteria...
April 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27029452/-assessing-the-impact-of-citicoline-on-the-efficiency-of-rehabilitation-measures-in-patients-with-ischemic-stroke
#12
A V Mushba, D S Ivanova, O I Vinogradov
OBJECTIVE: To evaluate the effect of citicoline on the efficacy of rehabilitation measures in patients with ischemic stroke (IS). MATERIAL AND METHODS: Sixty patients were examined in the acute period of hemispheric IS. All patients underwent routine comprehensive treatment. The study group included 30 patients who received citicoline within the first 24 hours after IS onset. The control group consisted of 30 patients who were not treated with citicoline. The examination of patients included the assessment of neurological deficit, cognitive functions, P300 evoked potentials, head single photon emission computed tomography...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26999113/long-term-treatment-with-citicoline-prevents-cognitive-decline-and-predicts-a-better-quality-of-life-after-a-first-ischemic-stroke
#13
Jose Alvarez-Sabín, Estevo Santamarina, Olga Maisterra, Carlos Jacas, Carlos Molina, Manuel Quintana
Stroke, as the leading cause of physical disability and cognitive impairment, has a very significant impact on patients' quality of life (QoL). The objective of this study is to know the effect of citicoline treatment in Qol and cognitive performance in the long-term in patients with a first ischemic stroke. This is an open-label, randomized, parallel study of citicoline vs. usual treatment. All subjects were selected 6 weeks after suffering a first ischemic stroke and randomized into parallel arms. Neuropsychological evaluation was performed at 1 month, 6 months, 1 year and 2 years after stroke, and QoL was measured using the EuroQoL-5D questionnaire at 2 years...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26979720/citicoline-retards-myopia-progression-following-form-deprivation-in-guinea-pigs
#14
Junfeng Mao, Shuangzhen Liu, Chunyan Fu
The retinal dopaminergic system is involved in the myopic shift following form deprivation. Citicoline has been demonstrated to stimulate the dopaminergic system in the brain and retina. Furthermore, citicoline has been used in many neurogenic diseases, such as senile cognitive impairment, stroke and Parkinson's disease as well as in amblyopia and glaucoma. Our aim was to investigate the effect of citicoline on the refractive state and retinal dopamine level in form deprivation myopia of guinea pigs. Guinea pigs, at an age of four weeks, were randomly divided into normal control, deprivation, deprived + citicoline and deprived + vehicle groups...
June 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26959141/medical-therapies-of-amblyopia-translational-research-to-expand-our-treatment-armamentarium
#15
Charlotte Gore, Carolyn Wu
Amblyopia is a developmental brain disorder in which vision is lost due to asymmetric or inadequate visual stimulation early in life. Although amblyopia is responsive to treatment if therapy is initiated early, treatment of older children and adults is usually unsuccessful due to closure of a window of cortical brain plasticity. Extensive basic research has been devoted to understanding modulators in shaping the visual cortex during the critical period of plasticity, and to providing potential clinical applications of neurotransmitters in the treatment of amblyopia...
2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/26902360/anticonvulsant-effects-of-combined-treatment-with-citicoline-and-valproate-on-the-model-of-acute-generalized-convulsions-induced-by-pentylenetetrazole-in-wistar-rats
#16
M N Karpova, L V Kuznetsova, K A Zin'kovskii, N V Klishina
We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalized convulsions in male Wistar rats. Combined treatment with citicoline and valproate in minimum effective doses (70 and 300 mg/kg, respectively) potentiated the anticonvulsant properties of both agents...
February 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26658924/citicoline-treatment-improves-measures-of-impulsivity-and-task-performance-in-chronic-marijuana-smokers-a-pilot-bold-fmri-study
#17
Staci A Gruber, Kelly A Sagar, Mary Kathryn Dahlgren, Atilla Gonenç, Nina A Conn, Jeffrey P Winer, David Penetar, Scott E Lukas
OBJECTIVE: Citicoline is an endogenous nucleotide that has historically been used to treat stroke, traumatic brain injury, and cognitive dysfunction. Research has also shown that citicoline treatment is associated with improved cognitive performance in substance-abusing populations. We hypothesized that marijuana (MJ) smokers who received citicoline would demonstrate improvement in cognitive performance as well as increased neural efficiency during tasks of cognitive control relative to those who received placebo...
September 30, 2015: International Journal of Neurology and Neurotherapy
https://www.readbyqxmd.com/read/26633368/cytidine-5-diphosphocholine-citicoline-in-glaucoma-rationale-of-its-use-current-evidence-and-future-perspectives
#18
REVIEW
Gloria Roberti, Lucia Tanga, Manuele Michelessi, Luciano Quaranta, Vincenzo Parisi, Gianluca Manni, Francesco Oddone
Cytidine 5'-diphosphocholine or citicoline is an endogenous compound that acts in the biosynthetic pathway of phospholipids of cell membranes, particularly phosphatidylcholine, and it is able to increase neurotrasmitters levels in the central nervous system. Citicoline has shown positive effects in Parkinson's disease and Alzheimer's disease, as well as in amblyopia. Glaucoma is a neurodegenerative disease currently considered a disease involving ocular and visual brain structures. Neuroprotection has been proposed as a valid therapeutic option for those patients progressing despite a well-controlled intraocular pressure, the main risk factor for the progression of the disease...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26608705/electropharmacogram-of-sceletium-tortuosum-extract-based-on-spectral-local-field-power-in-conscious-freely-moving-rats
#19
Wilfried Dimpfel, Leonie Schombert, Nigel Gericke
ETHNOPHARMACOLOGICAL RELEVANCE: The endemic succulent South African plant, Sceletium tortuosum (L.) N.E. Br. (synonym Mesembryanthemum tortuosum L.), of the family Mesembryathemaceae, has an ancient oral tradition history of use by San and Khoikhoi people as an integral part of the indigenous culture and materia medica. A special standardized extract of Sceletium tortuosum (Zembrin®) has been developed and tested pre-clinically in rats, and clinically in healthy subjects. AIM OF THE STUDY: The present investigation aimed at the construction of electropharmacograms of Zembrin® in the presence of three dosages (2...
January 11, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26521569/-neonatal-hypoxic-ischemic-encephalopathy-treated-with-acupuncture-combined-with-acupoint-injection-a-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Ying Tang, Qing Shang
OBJECTIVE: To observe the clinical efficacy difference in the treatment of neonatal hypoxic ischemic encephalopathy (NHIE) between the combined therapy of acupuncture land acupoint injection of nerve growth fac-tor (NGF) and the combined therapy of the intravenous drop of citicoline sodium and intramuscular injection of NGF. METHODS: Sixty-one cases of NHIE were randomized into an observation group (32 cases) and a control group (29 cases). In the observation group, acupuncture combined with acupint injection of NGF was adopted...
July 2015: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
keyword
keyword
3954
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"