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Continuum of HIV care

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https://www.readbyqxmd.com/read/29778263/hepatitis-c-virus-elimination-in-the-human-immunodeficiency-virus-coinfected-population-leveraging-the-existing-human-immunodeficiency-virus-infrastructure
#1
REVIEW
Meredith E Clement, Lauren F Collins, Julius M Wilder, Michael Mugavero, Taryn Barker, Susanna Naggie
The objective of this review is to consider how existing human immunodeficiency virus (HIV) infrastructure may be leveraged to inform and improve hepatitis C virus (HCV) treatment efforts in the HIV-HCV coinfected population. Current gaps in HCV care relevant to the care continuum are reviewed. Successes in HIV treatment are then applied to the HCV treatment model for coinfected patients. Finally, the authors give examples of HCV treatment strategies for coinfected patients in both domestic and international settings...
June 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29771786/the-continuum-of-hiv-care-in-rural-mozambique-the-implications-of-hiv-testing-modality-on-linkage-and-retention
#2
Elisa Lopez-Varela, Laura Fuente-Soro, Orvalho Joaquim Augusto, Charfudin Sacoor, Ariel Nhacolo, Esmeralda Karajeanes, Paula Vaz, Denise Naniche
INTRODUCTION: Context-specific improvements in the continuum of HIV care are needed in order to achieve the UNAIDS target of 90-90-90. This study aimed to assess the linkage to and retention in HIV care according to different testing modalities in rural southern Mozambique. METHODS: Adults newly diagnosed with HIV from voluntary counseling and testing (VCT), provider-initiated (PICT) and home-based HIV testing (HBT) services were prospectively enrolled between 2014- 2015 at the Manhiça District...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771781/lack-of-virological-suppression-among-young-hiv-positive-adults-in-botswana
#3
Vlad Novitsky, Tendani Gaolathe, Mompati Mmalane, Sikhulile Moyo, Unoda Chakalisa, Etienne Kadima Yankinda, Tafireyi Marukutira, Molly Pretorius Holme, Tumalano Sekoto, Simani Gaseitsiwe, Rosemary Musonda, Erik van Widenfelt, Kathleen M Powis, Nealia Khan, Scott Dryden-Peterson, Kara Bennett, Kathleen E Wirth, Eric Tchetgen Tchetgen, Pam Bachanas, Lisa A Mills, Refeletswe Lebelonyane, El-Halabi Shenaaz, Joseph Makhema, Shahin Lockman, M Essex
BACKGROUND: HIV-1 RNA load is the best biological predictor of HIV transmission and treatment response. The rate of virologic suppression among key sub-populations can guide HIV prevention programs. METHODS: The Botswana Combination Prevention Project performed a population-based household survey among adults in 30 communities in Botswana. Data collected included knowledge of HIV-positive status, ART coverage and virologic suppression (HIV-1 RNA ≤400 copies/mL)...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29768489/optimal-allocation-of-hiv-prevention-funds-for-state-health-departments
#4
Emine Yaylali, Paul G Farnham, Stacy Cohen, David W Purcell, Heather Hauck, Stephanie L Sansom
OBJECTIVE: To estimate the optimal allocation of Centers for Disease Control and Prevention (CDC) HIV prevention funds for health departments in 52 jurisdictions, incorporating Health Resources and Services Administration (HRSA) Ryan White HIV/AIDS Program funds, to improve outcomes along the HIV care continuum and prevent infections. METHODS: Using surveillance data from 2010 to 2012 and budgetary data from 2012, we divided the 52 health departments into 5 groups varying by number of persons living with diagnosed HIV (PLWDH), median annual CDC HIV prevention budget, and median annual HRSA expenditures supporting linkage to care, retention in care, and adherence to antiretroviral therapy...
2018: PloS One
https://www.readbyqxmd.com/read/29762160/childbirth-experiences-of-women-living-with-hiv-a-neglected-event-in-the-prevention-of-mother-to-child-transmission-care-continuum
#5
Cody Cichowitz, Melissa H Watt, Blandina T Mmbaga
No abstract text is available yet for this article.
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29737610/monitoring-the-hiv-continuum-of-care-in-key-populations-across-europe-and-central-asia
#6
A E Brown, K Attawell, D Hales, B D Rice, A Pharris, V Supervie, D Van Beckhoven, V C Delpech, M An der Heiden, U Marcus, M Maly, T Noori
OBJECTIVES: The aim of the study was to measure and compare national continuum of HIV care estimates in Europe and Central Asia in three key subpopulations: men who have sex with men (MSM), people who inject drugs (PWID) and migrants. METHODS: Responses to a 2016 European Centre for Disease Prevention and Control (ECDC) survey of 55 European and Central Asian countries were used to describe continuums of HIV care for the subpopulations. Data were analysed using three frameworks: Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets; breakpoint analysis identifying reductions between adjacent continuum stages; quadrant analysis categorizing countries using 90% cut-offs for continuum stages...
May 8, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29727458/access-to-antiretroviral-therapy-in-hiv-infected-children-aged-0-19-years-in-the-international-epidemiology-databases-to-evaluate-aids-iedea-global-cohort-consortium-2004-2015-a-prospective-cohort-study
#7
Sophie Desmonde, Franck Tanser, Rachel Vreeman, Elom Takassi, Andrew Edmonds, Pagakrong Lumbiganon, Jorge Pinto, Karen Malateste, Catherine McGowan, Azar Kariminia, Marcel Yotebieng, Fatoumata Dicko, Constantin Yiannoutsos, Mwangelwa Mubiana-Mbewe, Kara Wools-Kaloustian, Mary-Ann Davies, Valériane Leroy
INTRODUCTION: Access to antiretroviral therapy (ART) is a global priority. However, the attrition across the continuum of care for HIV-infected children between their HIV diagnosis and ART initiation is not well known. We analyzed the time from enrollment into HIV care to ART initiation in HIV-infected children within the International Epidemiology Databases to Evaluate AIDS (IeDEA) Global Cohort Consortium. METHODS AND FINDINGS: We included 135,479 HIV-1-infected children, aged 0-19 years and ART-naïve at enrollment, between 1 January 2004 and 31 December 2015, in IeDEA cohorts from Central Africa (3 countries; n = 4,948), East Africa (3 countries; n = 22,827), West Africa (7 countries; n = 7,372), Southern Africa (6 countries; n = 93,799), Asia-Pacific (6 countries; n = 4,045), and Latin America (7 countries; n = 2,488)...
May 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29727296/croi-2018-advances-in-antiretroviral-therapy
#8
Hong-Van Tieu, Barbara S Taylor, Joyce Jones, Timothy J Wilkin
The 2018 Conference on Retroviruses and Opportunistic Infections (CROI) showcased exciting data on new investigational agents including MK-8591 and tri-specific antibody targeting 3 highly conserved epitopes on HIV-1 in a single antibody. Clinical trials of initial antiretroviral therapy (ART) and switch studies involving bictegravir/emtricitabine/tenofovir alafenamide were presented. Intensification of initial ART with integrase strand transfer inhibitors did not increase the risk of immune reconstitution inflammatory syndrome...
May 2018: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/29725192/african-american-clergy-perspectives-about-the-hiv-care-continuum-results-from-a-qualitative-study-in-jackson-mississippi
#9
Amy Nunn, Sharon Parker, Katryna McCoy, Mauda Monger, Melverta Bender, Joanna Poceta, Julia Harvey, Gladys Thomas, Kendra Johnson, Yusuf Ransome, Cassandra Sutten Coats, Phil Chan, Leandro Mena
Mississippi has some of the most pronounced racial disparities in HIV infection in the country; African Americans comprised 37% of the Mississippi population but represented 80% of new HIV cases in 2015. Improving outcomes along the HIV care continuum, including linking and retaining more individuals and enhancing adherence to medication, may reduce the disparities faced by African Americans in Mississippi. Little is understood about clergy's views about the HIV care continuum. We assessed knowledge of African American pastors and ministers in Jackson, Mississippi about HIV and the HIV care continuum...
2018: Ethnicity & Disease
https://www.readbyqxmd.com/read/29717402/assessing-the-effect-of-recent-incarceration-in-prison-on-hiv-care-retention-and-viral-suppression-in-two-states
#10
Michael Costa, Brian T Montague, Liza Solomon, Cara Sammartino, Roee Gutman, Chava Zibman, David Rosen, Josiah D Rich
The prevalence of HIV among people in correctional facilities remains much higher than that of the general population. Numerous studies have demonstrated the effectiveness and acceptability of HIV treatment for individuals incarcerated in US prisons and jails. However, the period following incarceration is characterized by significant disruptions in HIV care. These disruptions include failure to link in a timely manner (or at all) to community care post-release, as well as not being retained in care after linking...
May 1, 2018: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29712626/a-gamified-smartphone-app-to-support-engagement-in-care-and-medication-adherence-for-hiv-positive-young-men-who-have-sex-with-men-allyquest-development-and-pilot-study
#11
Lisa Hightow-Weidman, Kathryn Muessig, Kelly Knudtson, Mala Srivatsa, Ellena Lawrence, Sara LeGrand, Anna Hotten, Sybil Hosek
BACKGROUND: HIV disproportionately impacts young men who have sex with men (YMSM) who experience disparities across the HIV care continuum. Addressing antiretroviral therapy (ART) adherence among YMSM is an urgent public health priority. Technology-based interventions-particularly mobile health platforms-can provide tailored adherence interventions and allow YMSM to engage and connect with others. OBJECTIVE: The objective of this study was to describe the development of AllyQuest, a novel, theoretically-based, smartphone app designed to improve engagement in care and ART adherence and social support among HIV-positive YMSM...
April 30, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29683993/impact-of-improved-hiv-care-and-treatment-on-prep-effectivenesss-in-the-united-states-2016-2020
#12
Nidhi Khurana, Emine Yaylali, Paul G Farnham, Katherine A Hicks, Benjamin T Allaire, Evin Jacobson, Stephanie L Sansom
BACKGROUND: The effect of improving diagnosis, care, and treatment of persons living with HIV (PLWH) on PrEP effectiveness in the United States has not be well established. METHODS: We used a dynamic, compartmental model that simulates the sexually active US population. We investigated the change in cumulative HIV incidence from 2016 to 2020 for three HIV care continuum levels, and the marginal benefit of PrEP compared with each. We also explored the marginal benefit of PrEP for individual risk groups, and as PrEP adherence, coverage and dropout rates varied...
April 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29679811/hepatitis-c-care-continuum-and-associated-barriers-among-people-who-inject-drugs-in-chennai-india
#13
Eshan U Patel, Sunil S Solomon, Allison M Mcfall, Aylur K Srikrishnan, Amrose Pradeep, Paneerselvam Nandagopal, Oliver Laeyendecker, Aaron A R Tobian, David L Thomas, Mark S Sulkowski, M Suresh Kumar, Shruti H Mehta
BACKGROUND: Little is known regarding barriers to hepatitis C virus (HCV) treatment among people who inject drugs (PWID) in low-resource settings, particularly in the era of direct-acting antiviral therapies. METHODS: Between March, 2015-August, 2016, a cross-sectional survey was administered to community-based PWID in Chennai, India to examine the HCV care continuum and associated barriers. Adjusted prevalence ratios (APR) were estimated by multivariable Poisson regression with robust variance...
April 18, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29678121/the-relationship-between-adverse-neighborhood-socioeconomic-context-and-hiv-continuum-of-care-outcomes-in-a-diverse-hiv-clinic-cohort-in-the-southern-united-states
#14
Peter F Rebeiro, Chanelle J Howe, William B Rogers, Sally S Bebawy, Megan Turner, Asghar Kheshti, Catherine C McGowan, Stephen P Raffanti, Timothy R Sterling
Retention in care and viral suppression are critical to delaying HIV progression and reducing transmission. Neighborhood socioeconomic context (NSEC) may affect HIV care receipt. We therefore assessed NSEC's impact on retention and viral suppression in a diverse HIV clinical cohort. HIV-positive adults with ≥1 visit at the Vanderbilt Comprehensive Care Clinic and 5-digit ZIP code tabulation area (ZCTA) information between 2008 and 2012 contributed. NSEC z-score indices used neighborhood-level socioeconomic indicators for poverty, education, labor-force participation, proportion of males, median age, and proportion of residents of black race by ZCTA...
April 20, 2018: AIDS Care
https://www.readbyqxmd.com/read/29669456/perceived-hiv-related-stigma-among-university-students-in-south-africa-implications-for-hiv-testing
#15
Firoza Haffejee, Brendan Maughan-Brown, Thulasizwe Buthelezi, Ayesha B M Kharsany
HIV-related stigma, and particularly perceived stigma, has a negative impact across the HIV care continuum. This study adds to our understanding of stigma by assessing how perceived stigma varies from one context to another and how such differences are associated with the location where individuals would prefer an HIV test. We used self-administered questionnaire data (n = 378) obtained from a convenience sample of students (18 years and older) attending a tertiary education institution in Durban, South Africa...
April 18, 2018: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29657955/challenges-across-the-hiv-care-continuum-for-patients-with-hiv-1-tb-co-infection-in-atlanta-ga
#16
Marcos C Schechter, Destani Bizune, Michelle Kagei, David P Holland, Carlos Del Rio, Aliya Yamin, Omar Mohamed, Alawode Oladele, Yun F Wang, Paulina A Rebolledo, Susan M Ray, Russell R Kempker
Background: Antiretroviral therapy (ART) for persons with HIV infection prevents tuberculosis (TB) disease. Additionally, sequential ART after initiation of TB treatment improves outcomes. We examined ART use, retention in care, and viral suppression (VS) before, during, and 3 years following TB treatment for an inner-city cohort in the United States. Methods: Retrospective cohort study among persons treated for culture-confirmed TB between 2008 and 2015 at an inner-city hospital...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29629649/two-diseases-same-person-moving-toward-a-combined-hiv-and-tuberculosis-continuum-of-care
#17
Reuben Granich, Somya Gupta
The human immunodeficiency virus (HIV) and Mycobacterium tuberculosis syndemic remains a global public health threat. Separate HIV and tuberculosis (TB) global targets have been set; however, success will depend on achieving combined disease control objectives and care continua. The objective of this study was to review available policy, budgets, and data to reconceptualize TB and HIV disease control objectives by combining HIV and TB care continua. For 22 World Health Organization (WHO) TB and TB/HIV priority countries, we used 2015 data from the HIV90-90-90watch website, UNAIDS AIDSinfo, and WHO 2016 and 2017 Global TB Reports...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29617437/patient-nominated-supporters-as-facilitators-for-engagement-in-hiv-care-in-a-referral-hospital-in-peru-a-retrospective-cohort-study
#18
Mateo Prochazka, Larissa Otero, Kelika A Konda, Elsa González-Lagos, Juan Echevarría, Eduardo Gotuzzo
Patient-nominated supporters can potentially improve the continuum of HIV care. We retrospectively determined factors associated with having a patient-nominated supporter among people living with HIV (PLWH), and its association with retention in care and viral suppression. We analysed registries of adults evaluated by social workers (n = 1345) at a referral hospital in Peru between 2011-2014. Nondisclosure of HIV status was associated with lacking supporters (aPR: 5.41, 95% CI: 3.83-7.64). Retention in care was 76...
2018: PloS One
https://www.readbyqxmd.com/read/29603112/identifying-spatial-variation-along-the-hiv-care-continuum-the-role-of-distance-to-care-on-retention-and-viral-suppression
#19
A S Terzian, N Younes, A E Greenberg, J Opoku, J Hubbard, L P Happ, P Kumar, R R Jones, A D Castel
Distance to HIV care may be associated with retention in care (RIC) and viral suppression (VS). RIC (≥ 2 HIV visits or labs ≥ 90 days apart in 12 months), prescribed antiretroviral therapy (ART), VS (< 200 copies/mL at last visit) and distance to care were estimated among 3623 DC Cohort participants receiving HIV care in 13 outpatient clinics in Washington, DC in 2015. Logistic regression models and geospatial statistics were computed. RIC was 73%; 97% were on ART, among whom 77% had VS. ZIP code-level clusters of low RIC and high VS were found in Northwest DC, and low VS in Southeast DC...
March 30, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29602851/patient-perspectives-on-the-hiv-continuum-of-care-in-london-a-qualitative-study-of-people-diagnosed-between-1986-and-2014
#20
Jane Bruton, Tanvi Rai, Sophie Day, Helen Ward
OBJECTIVES: To describe the experiences of the HIV treatment cascade of diagnosis, engagement with care and initiation of treatment from the perspective of patients; we explored whether this differed according to the year of their diagnosis, for example, whether they had experienced HIV care in the pretreatment era. DESIGN: Qualitative interview study with framework analysis. SETTING: Two large HIV adult outpatient clinics in central London...
March 30, 2018: BMJ Open
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