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https://www.readbyqxmd.com/read/29668141/-prevalence-and-risk-factors-associated-to-tuberculosis-and-non-tuberculous-mycobacterial-infections-in-hiv-positive-patients-in-bogot%C3%A3
#1
Magda Beltrán-León, Francy Pérez-Llanos, Liliana Sánchez, Carlos Parra-López, Myriam Navarrete, Ricardo Sánchez, Carlos Awad, Ana María Granada, Edgardo Quintero, Óscar Briceño, Óscar Cruz, Martha Isabel Murcia
INTRODUCTION: Tuberculosis is one of the most widely distributed infectious diseases worldwide. It is the most common cause of mortality among AIDS patients. In Colombia, 12,918 tuberculosis cases were notified, and 926 deaths were reported in 2015. OBJECTIVE: To determine the prevalence and risk factors associated to mycobacterial infections in HIVpositive patients in two public hospitals from Bogotá. MATERIALS AND METHODS: A prospective and descriptive study was carried out by an active search for tuberculosis cases and non-tuberculous mycobacterial infections in HIV-positive patients...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667577/people-living-with-undiagnosed-hiv-infection-and-a-low-cd4-count-estimates-from-surveillance-data-italy-2012-to-2014
#2
Vincenza Regine, Maria Dorrucci, Patrizio Pezzotti, Alessia Mammone, Chantal Quinten, Anastasia Pharris, Barbara Suligoi, The Regional Representatives Of The National Hiv Surveillance System
Background and aimsLate HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count < 350 cells/mm3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 -2014 were obtained from the national HIV surveillance system...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29667336/optimal-breastfeeding-durations-for-hiv-exposed-infants-the-impact-of-maternal-art-use-infant-mortality-and-replacement-feeding-risk
#3
Divya Mallampati, Rachel L MacLean, Roger Shapiro, Francois Dabis, Barbara Engelsmann, Kenneth A Freedberg, Valeriane Leroy, Shahin Lockman, Rochelle Walensky, Nigel Rollins, Andrea Ciaranello
INTRODUCTION: In 2010, the WHO recommended women living with HIV breastfeed for 12 months while taking antiretroviral therapy (ART) to balance breastfeeding benefits against HIV transmission risks. To inform the 2016 WHO guidelines, we updated prior research on the impact of breastfeeding duration on HIV-free infant survival (HFS) by incorporating maternal ART duration, infant/child mortality and mother-to-child transmission data. METHODS: Using the Cost-Effectiveness of Preventing AIDS Complications (CEPAC)-Infant model, we simulated the impact of breastfeeding duration on 24-month HFS among HIV-exposed, uninfected infants...
April 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29666424/cardiovascular-markers-of-inflammation-and-serum-lipid-levels-in-hiv-infected-patients-with-undetectable-viremia
#4
Klaudija Višković, Snježana Židovec Lepej, Ana Gorenec, Ivana Grgić, Davorka Lukas, Šime Zekan, Anja Dragobratović, Maja Trupković, Josip Begovac
Patients successfully treated for HIV infection still have an increased risk for cardiovascular morbidity and mortality, which might be related not only to traditional risks, but also to inflammation and dyslipidemia. We examined the relationship of serum lipid levels with plasma biomarkers of inflammation using a composite inflammatory burden score (IBS) based on individual (>75th percentile) measurements from the following seven markers: CD40L, tPA, MCP-1, IL-8, IL-6, hCRP and P-selectin. IBS was categorized as 0 (none of the biomarkers >75th percentile), 1, 2 and 3 or more scores...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663871/design-of-a-randomized-controlled-trial-of-zinc-supplementation-to-improve-markers-of-mortality-and-hiv-disease-progression-in-hiv-positive-drinkers-in-st-petersburg-russia
#5
Natalia Gnatienko, Matthew S Freiberg, Elena Blokhina, Tatiana Yaroslavtseva, Carly Bridden, Debbie M Cheng, Christine E Chaisson, Dmitry Lioznov, Sally Bendiks, Glory Koerbel, Sharon M Coleman, Evgeny Krupitsky, Jeffrey H Samet
Background Russia continues to have an uncontrolled HIV epidemic and its per capita alcohol consumption is among the highest in the world. Alcohol use among HIV-positive individuals is common and is associated with worse clinical outcomes. Alcohol use and HIV each lead to microbial translocation, which in turn results in inflammation. Zinc supplementation holds potential for lowering levels of biomarkers of inflammation, possibly as a consequence of its impact on intestinal permeability. This paper describes the protocol of a double-blinded randomized placebo-controlled trial of zinc supplementation in St...
April 17, 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29663282/the-frozen-brain-state-of-cryptococcus-gattii-a-globe-trotting-tropical-neurotropic-fungus
#6
Paul T Akins, Brian Jian
Initially reported in tropical regions, Cryptococcus gattii infection is now diagnosed globally. METHODS: case report; Literature review. Although initial reports described outbreaks of pulmonary and central nervous system (CNS) disease in tropical regions such as Australia and New Guinea, it is now clear that Cryptococcus gattii is a global, neurotropic pathogen. In contrast with C. neoformans, C. gattii patients are more likely to present with cryptococcomas in the brain and lungs and are often HIV negative...
April 16, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29662603/increased-mortality-among-hiv-infected-patients-with-cryptococcal-antigenemia-in-guinea-bissau
#7
Ditte Thomsen, Cecilie Juul Hviid, Bo Langhoff Hønge, Candida Medina, David Da Silva Té, Faustino Gomes Correira, Lars Østergaard, Christian Erikstrup, Christian Wejse, Alex Lund Laursen, Sanne Jespersen
Cryptococcal antigenemia may precede development of cryptococcal meningitis and death among patients with advanced HIV infection. Among 200 retrospectively and randomly selected ART-naïve patients with CD4 counts < 100 cells/μl from Guinea-Bissau, 20 (10%) had a positive cryptococcal antigen test. Self-reported headache and fever were predictors of a positive test, while cryptococcal antigenemia was a strong predictor of death within the first year of follow-up, MRR 2.22 (95% CI: 1.15-4.30). Screening for cryptococcal antigenemia should be implemented for patients with advanced HIV in Guinea-Bissau...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29661246/risk-factors-and-outcomes-for-the-q151m-and-t69-insertion-hiv-1-resistance-mutations-in-historic-uk-data
#8
Oliver T Stirrup, David T Dunn, Anna Tostevin, Caroline A Sabin, Anton Pozniak, David Asboe, Alison Cox, Chloe Orkin, Fabiola Martin, Patricia Cane
BACKGROUND: The prevalence of HIV-1 resistance to antiretroviral therapies (ART) has declined in high-income countries over recent years, but drug resistance remains a substantial concern in many low and middle-income countries. The Q151M and T69 insertion (T69i) resistance mutations in the viral reverse transcriptase gene can reduce susceptibility to all nucleoside/tide analogue reverse transcriptase inhibitors, motivating the present study to investigate the risk factors and outcomes associated with these mutations...
April 16, 2018: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29661197/relevance-and-acceptability-of-using-the-quantiferon-gold-test-qgit-to-screen-cd4-blood-draws-for-latent-tb-infection-among-plhiv-in-south-africa-formative-qualitative-research-findings-from-the-teko-trial
#9
Deanna Kerrigan, Carrie Tudor, Katlego Motlhaoleng, Limakatso Lebina, Cokiswa Qomfu, Ebrahim Variava, Sandy Chon, Neil Martinson, Jonathan E Golub
BACKGROUND: Tuberculosis (TB) is the leading cause of mortality among people living with HIV (PLHIV), despite the availability of effective preventive therapy. The TEKO trial is assessing the impact of using a blood test, Quantiferon-TB Gold In-Tube Test (QGIT), to screen for latent TB compared to the Tuberculin Screening Test (TST) among PLHIV in South Africa. METHODS: Fifty-six qualitative interviews were conducted with PLHIV and clinical providers participating in the TEKO trial...
April 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29659759/community-acquired-legionella-pneumonia-in-hiv-infected-adult-patients-a-matched-case-control-study
#10
Catia Cillóniz, Lucia Miguel-Escuder, María Luisa Pedro-Bonet, Vicenç Falcó, Yessica Lopez, Carolina García-Vidal, Albert Gabarrús, Asunción Moreno, Antoni Torres, José M Miró
We investigated whether the clinical presentations and outcomes (length of hospital stay [LOS], intensive care unit[ICU] admission, 30-day mortality) of Legionella pneumonia in HIV-infected patients were comparable to those without HIV infection.Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.
April 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29659636/prognostic-score-to-predict-mortality-during-tb-treatment-in-tb-hiv-co-infected-patients
#11
Duc T Nguyen, Helen E Jenkins, Edward A Graviss
BACKGROUND: Estimating mortality risk during TB treatment in HIV co-infected patients is challenging for health professionals, especially in a low TB prevalence population, due to the lack of a standardized prognostic system. The current study aimed to develop and validate a simple mortality prognostic scoring system for TB/HIV co-infected patients. METHODS: Using data from the CDC's Tuberculosis Genotyping Information Management System of TB patients in Texas reported from 01/2010 through 12/2016, age ≥15 years, HIV(+), and outcome being "completed" or "died", we developed and internally validated a mortality prognostic score using multiple logistic regression...
2018: PloS One
https://www.readbyqxmd.com/read/29657212/mortality-in-the-elderly-with-acute-kidney-injury-in-an-internal-medicine-department-in-abidjan-cote-d-ivoire
#12
Hubert Kouamé Yao, Allah Yves Omer Binan, Serge-Didier Konan, Koffi Justin N'Da, Sery Patrick Diopoh
Acute kidney injury (AKI) in the elderly is characterized by high mortality. The objective of this study is to identify the causes of death in the elderly with AKI. This is a prospective cohort study with a descriptive purpose which was carried out during the period from January 2009 to December 2014 in the Department of Nephrology-Internal Medicine of Treichville University Hospital. The diagnosis of AKI was made on the basis of serum creatinine (SCr) values determined during hospitalization, according to KDIGO classification...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29655949/incidence-and-predictors-of-6-months-mortality-after-an-acute-heart-failure-event-in-rural-uganda-the-mbarara-heart-failure-registry-mahfer
#13
Fardous Charles Abeya, Boniface Amanee Elias Lumori, Suzan Joan Akello, Brian H Annex, Andrew J Buda, Samson Okello
OBJECTIVE: We sought to estimate the incidence and predictors of all-cause mortality 6 months after heart failure hospitalization in Uganda. METHODS: Mbarara Heart Failure Registry is a cohort of patients hospitalized with a clinical diagnosis of heart failure at Mbarara Regional Referral Hospital, Uganda. We measured serum electrolytes, cardiac markers, and echocardiograms. All participants were followed until death or end of 6 months. We used Fine and Gray models to estimate the incidence and predictors all-cause mortality...
March 29, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29649107/impaired-hematologic-status-in-relation-to-clinical-outcomes-among-hiv-infected-adults-from-uganda-a-prospective-cohort-study
#14
Amara E Ezeamama, David Guwatudde, Alla Sikorskii, Edmond K Kabagambe, Raybun Spelts, Grace Vahey, Jenifer I Fenton, Wafaie W Fawzi
Impaired hematologic status (IHS) was investigated as a determinant of immune function defined as cluster of differentiation 4 (CD4) T-helper cell count, quality of life (QOL) weight and hospitalization/mortality over 18-months among 398 adult persons living with HIV/AIDS (PLWHA) on anti-retroviral therapy. IHS was defined as having anemia at baseline (Hemoglobin: <12 g/dL for women and <13 g/dL for men), time-updated anemia or having low (<30 μg/L) or high (>200 μg/L for men and >150 μg/L for women) ferritin levels at baseline...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29649095/measuring-quality-gaps-in-tb-screening-in-south-africa-using-standardised-patient-analysis
#15
Carmen S Christian, Ulf-G Gerdtham, Dumisani Hompashe, Anja Smith, Ronelle Burger
This is the first multi-district Standardised Patient (SP) study in South Africa. It measures the quality of TB screening at primary healthcare (PHC) facilities. We hypothesise that TB screening protocols and best practices are poorly adhered to at the PHC level. The SP method allows researchers to observe how healthcare providers identify, test and advise presumptive TB patients, and whether this aligns with clinical protocols and best practice. The study was conducted at PHC facilities in two provinces and 143 interactions at 39 facilities were analysed...
April 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29649078/point-of-diagnosis-and-patient-retention-in-hiv-care-in-western-kenya
#16
Becky L Genberg, Hana Lee, Joseph W Hogan, Fatma Some, Juddy Wachira, Xiaotian K Wu, Paula Braitstein
BACKGROUND: Home-based counseling and testing (HBCT) achieves earlier HIV diagnosis than other testing modalities; however, retention in care for these healthier patients is unknown. The objective of this study was to determine the association between point of HIV testing and retention in care and mortality. SETTING: AMPATH (Academic Model Providing Access to Healthcare) has provided HIV care in western Kenya since 2001. METHODS: AMPATH initiated HBCT in 2007...
April 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29630022/access-to-fertility-treatment-for-mixed-status-couples-with-human-immunodeficiency-virus
#17
Jennifer F Kawwass, Lisa B Haddad, Jean R Anderson, Denise J Jamieson
In an effort to place the recent Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report publications regarding conception options for mixed-status couples with human immunodeficiency virus (HIV) in perspective, we review the historical evolution of conception options for mixed-status couples with HIV with particular focus on the potential need for fertility treatment and the feasibility of accessing such treatment.
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29629518/atypical-presentation-of-pneumocystis-jirovecii-infection-in-hiv-infected-patients-three-different-manifestations
#18
Bongyoung Kim, Jieun Kim, Seung Sam Paik, Hyunjoo Pai
Advances in the treatment and prevention of Pneumocystis jirovecii infection (PJI) in human immunodeficiency virus (HIV) patients decreased incidence and mortality dramatically, however, it may be associated with an increased frequency of unusual manifestation such as cystic formation, pneumothorax, focal infiltration, nodular formation, or extrapulmonary lesions. We report three cases of PJI with atypical manifestations. Each case demonstrates different clinical features: multiple nodular pulmonary lesion (32-year-old man with abnormal chest X-ray finding), subpleural mass-like lesion (43-year-old man with left visual loss and right pleuritic chest pain), and extrapulmonary mass-like lesions in the liver, lymph nodes, and small bowel (39-year-old man with cough, sputum, and dyspnea)...
April 9, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29629291/zinc-copper-cd4-t-cell-count-and-some-hematological-parameters-of-hiv-infected-subjects-in-southern-nigeria
#19
Enosakhare A Asemota, Ifeyinwa M Okafor, Henshaw U Okoroiwu, Ewaro R Ekong, Stanley Obialor Anyanwu, Esienanwan Esien Efiong, Francis Udomah
Background: Low concentration of trace elements has been associated with poor prognosis and mortality in HIV infection. Methods: A cross sectional study was conducted among 100 HIV-infected subjects (70 were on ART treatment, while 30 were ART naïve). Fifty (50) apparently healthy controls were enrolled. Concentration of serum levels of zinc and copper was done using atomic absorption spectrometric method, while complete blood count was determined using automated blood analyzer...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29628338/stroke-in-human-immunodeficiency-virus-infected-individuals-in-sub-saharan-africa-ssa-a-systematic-review
#20
Amir Abdallah, Jonathan L Chang, Cumara B O'Carroll, Abdu Musubire, Felicia C Chow, Anthony L Wilson, Mark J Siedner
BACKGROUND: Human immunodeficiency virus (HIV) infection is associated with worse outcomes after stroke, but this association is less well-described in sub-Saharan Africa (SSA). We reviewed literature on stroke among people living with HIV (PLWH) in SSA. METHODS: We systematically reviewed published literature for original clinical stroke studies conducted in SSA that included PLWH. We included studies that reported data on presenting characteristics, risk factors, and/or outcomes after stroke...
April 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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