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https://www.readbyqxmd.com/read/29045944/prevalence-estimates-of-rare-congenital-anomalies-by-integrating-two-population-based-registries-in-tuscany-italy
#1
Alessio Coi, Michele Santoro, Anna Pierini, Sonia Marrucci, Federica Pieroni, Fabrizio Bianchi
BACKGROUND/AIMS: Population-based registries play a key role in the epidemiological surveillance of congenital anomalies (CAs). This study is aimed at improving the epidemiological surveillance and providing prevalence estimates of rare CAs using the Registry of Rare Diseases as an added data source to the Registry of Congenital Anomalies. METHODS: Cases of diagnosed rare CAs (2006-2013) were extracted from the Tuscany Registry of Rare Diseases and the Tuscany Registry of Congenital Anomalies in order to set up an integrated dataset...
September 19, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/29045936/anti-diabetic-potential-of-the-leaves-of-anisomeles-malabarica-in-streptozotocin-induced-diabetic-rats
#2
Peddanna Kotha, Kameswara Rao Badri, Ramya Nagalapuram, Rajasekhar Allagadda, Appa Rao Chippada
BACKGROUND/AIMS: Diabetes mellitus is a pandemic metabolic disorder that is affecting a majority of populations in recent years. There is a requirement for new drugs that are safer and cheaper due to the side effects associated with the available medications. METHODS: We investigated the anti-diabetic activity of leaves of Anisomeles malabarica following bioactivity guided fractionation. The different solvent (hexane, ethyl acetate, methanol and water) extracts of A...
October 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29045754/genomic-studies-of-local-adaptation-in-natural-plant-populations
#3
Victoria L Sork
Local adaptation arises as a result of selection by the local environment favoring phenotypes that enhance fitness. Geographic patterns of phenotypic variation are in part due to this selective process. Classically, the genetic basis of those phenotypes has been studied in plant populations using a quantitative genetic approach in which plants from different source populations are grown in common environments, in reciprocal transplant experiments, or in studies across a wide geographic and environmentally heterogeneous area...
October 14, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29045676/reproductive-plasticity-of-an-invasive-insect-pest-rice-water-weevil-coleoptera-curculionidae
#4
Yunshang Huang, Yan Ao, Mingxing Jiang, Charles Burks
Reproductive plasticity is a key determinant of species invasiveness. However, there are a limited number of studies addressing this issue in exotic insects. The rice water weevil Lissorhoptrus oryzophilus Kuschel (Coleoptera: Curculionidae), which is native to North America, is one of the most invasive insect pests in east Asia. In this study, we investigated the reproductive status of first-generation females (progeny of overwintered weevils) from five geographic regions in southern and northern China in the field, and reproductive status and ovipositional features of females provided with suitable host plants in the laboratory after collection...
October 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29045531/phylogenetic-and-functional-signals-in-gymnosperm-ovular-secretions
#5
Massimo Nepi, Stefan Little, Massimo Guarnieri, Daniele Nocentini, Natalie Prior, Julia Gill, P Barry Tomlinson, Stefanie M Ickert-Bond, Cary Pirone, Ettore Pacini, Patrick von Aderkas
Background and Aims: Gymnosperms are either wind-pollinated (anemophilous) or both wind- and insect-pollinated (ambophilous). Regardless of pollination mode, ovular secretions play a key role in pollen capture, germination and growth; they are likely also involved in pollinator reward. Little is known about the broad-scale diversity of ovular secretions across gymnosperms, and how these may relate to various reproductive functions. This study analyses the sugar and amino acid profiles of ovular secretions across a range of ambophilous (cycads and Gnetales) and anemophilous gymnosperms (conifers) to place them in an evolutionary context of their possible functions during reproduction...
October 16, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29045253/gut-microbial-diversity-in-hiv-infection-post-combined-antiretroviral-therapy-a-key-target-for-prevention-of-cardiovascular-disease
#6
Mohamed El-Far, Cécile L Tremblay
PURPOSE OF REVIEW: Although the HIV-infected population is living longer and getting older under current treatment regimens, significant challenges arise for health management as the infection is associated with various premature aging phenotypes, particularly increased incidence of cardiovascular diseases (CVDs). Here we review the current understanding of HIV-related gut dysbiosis in association with CVD and advances in clinical trials aiming to restore gut microbial diversity. RECENT FINDING: Identification of a unique signature for gut dysbiosis in HIV infection between different cohorts remains challenging...
October 17, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29045052/a-review-of-wheat-diseases-a-field-perspective
#7
REVIEW
Melania Figueroa, Kim E Hammond-Kosack, Peter S Solomon
Wheat is one of the primary staple foods throughout the planet. Significant yield gains in wheat production over the past 40 years have resulted in a steady balance of supply versus demand. However, predicted global population growth rates and dietary changes necessitate substantial yield gains over the next several decades to meet this escalating demand. A key component to meeting this challenge is better management of fungal incited diseases, which can be responsible for 15-20% yield losses per annum. Prominent diseases of wheat that currently contribute to these losses include the rusts, the blotches and head blight/scab...
October 18, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29044818/possible-glimpses-into-early-speciation-the-effect-of-ovarian-fluid-on-sperm-velocity-accords-with-post-copulatory-isolation-between-two-guppy-populations
#8
Alessandro Devigili, John L Fitzpatrick, Clelia Gasparini, Indar W Ramnarine, Andrea Pilastro, Jonathan P Evans
Identifying mechanisms of reproductive isolation is key to understanding speciation. Among the putative mechanisms underlying reproductive isolation, sperm-female interactions (postmating-prezygotic barriers) are arguably the hardest to identify, not least because these are likely to operate at the cellular or molecular level. Yet sperm-female interactions offer great potential to prevent the transfer of genetic information between different populations at the initial stages of speciation. Here we provide a preliminary test for the presence of a putative postmating-prezygotic barrier operating between three populations of Trinidadian guppies (Poecilia reticulata), an internally fertilizing fish that inhabits streams with different levels of connectivity across Trinidad...
October 17, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29043773/coherence-spectroscopy-in-the-condensed-phase-insights-into-molecular-structure-environment-and-interactions
#9
Jacob C Dean, Gregory D Scholes
The role of coherences, or coherently excited superposition states, in complex condensed-phase systems has been the topic of intense interest and debate for a number of years. In many cases, coherences have been utilized as spectators of ultrafast dynamics or for identifying couplings between electronic states. In rare cases, they have been found to drive excited state dynamics directly. Interestingly though, the utilization of coherences as a tool for high-detail vibronic spectroscopy has largely been overlooked until recently, despite their encoding of key information regarding molecular structure, electronically sensitive vibrational modes, and intermolecular interactions...
October 18, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29043762/food-deserts-in-winnipeg-canada-a-novel-method-for-measuring-a-complex-and-contested-construct
#10
Joyce Slater, Stefan Epp-Koop, Megan Jakilazek, Chris Green
INTRODUCTION: "Food deserts" have emerged over the past 20 years as spaces of concern for communities, public health authorities and researchers because of their potential negative impact on dietary quality and subsequent health outcomes. Food deserts are residential geographic spaces, typically in urban settings, where low-income residents have limited or no access to retail food establishments with sufficient variety at affordable cost. Research on food deserts presents methodological challenges including retail food store identification and classification, identification of low-income populations, and transportation and proximity metrics...
October 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29043759/-highly-processed-highly-packaged-very-unhealthy-but-they-are-low-risk-exploring-intersections-between-community-food-security-and-food-safety
#11
Kelsey A Speed, Samantha B Meyer, Rhona M Hanning, Shannon E Majowicz
INTRODUCTION: Food insecurity and foodborne disease are important issues in Canada, and the public health actions taken to address them can be conceptualized as factors shaping the food environment. Given emerging evidence that these two areas may interrelate, the objective of this study was to explore ways in which community food security efforts and food safety practices (and the population health issues they aim to address) may intersect in British Columbia, Canada, and interpret what this might mean for conceptualizing and attaining healthier food environments...
October 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29043248/health-by-design-interweaving-health-promotion-into-environments-and-settings
#12
Andrew E Springer, Alexandra E Evans, Jaquelin Ortuño, Deborah Salvo, Maria Teresa Varela Arévalo
The important influence of the environmental context on health and health behavior-which includes place, settings, and the multiple environments within place and settings-has directed health promotion planners from a focus solely on changing individuals, toward a focus on harnessing and changing context for individual and community health promotion. Health promotion planning frameworks such as Intervention Mapping provide helpful guidance in addressing various facets of the environmental context in health intervention design, including the environmental factors that influence a given health condition or behavior, environmental agents that can influence a population's health, and environmental change methods...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29043059/thermal-plasticity-in-postembryonic-life-history-traits-of-a-widely-distributed-collembola-effects-of-macroclimate-and-microhabitat-on-genotypic-differences
#13
Sagnik Sengupta, Torbjørn Ergon, Hans Petter Leinaas
Life history traits in many ectotherms show complex patterns of variation among conspecific populations sampled along wide latitudinal or climatic gradients. However, few studies have assessed whether these patterns can be explained better by thermal reaction norms of multiple life history traits, covering major aspects of the life cycle. In this study, we compared five populations of a Holarctic, numerically dominant soil microarthropod species, Folsomia quadrioculata, sampled from a wide latitudinal gradient (56-81°N), for growth, development, fecundity, and survival across four temperatures (10, 15, 20, and 25°C) in common garden experiments...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29043057/flower-resource-and-land-management-drives-hoverfly-communities-and-bee-abundance-in-seminatural-and-agricultural-grasslands
#14
Andrew Lucas, James C Bull, Natasha de Vere, Penelope J Neyland, Dan W Forman
Pollination is a key ecosystem service, and appropriate management, particularly in agricultural systems, is essential to maintain a diversity of pollinator guilds. However, management recommendations frequently focus on maintaining plant communities, with the assumption that associated invertebrate populations will be sustained. We tested whether plant community, flower resources, and soil moisture would influence hoverfly (Syrphidae) abundance and species richness in floristically-rich seminatural and floristically impoverished agricultural grassland communities in Wales (U...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29043025/diversity-and-distribution-of-genetic-variation-in-gammarids-comparing-patterns-between-invasive-and-non-invasive-species
#15
Miguel Baltazar-Soares, Filipa Paiva, Yiyong Chen, Aibin Zhan, Elizabeta Briski
Biological invasions are worldwide phenomena that have reached alarming levels among aquatic species. There are key challenges to understand the factors behind invasion propensity of non-native populations in invasion biology. Interestingly, interpretations cannot be expanded to higher taxonomic levels due to the fact that in the same genus, there are species that are notorious invaders and those that never spread outside their native range. Such variation in invasion propensity offers the possibility to explore, at fine-scale taxonomic level, the existence of specific characteristics that might predict the variability in invasion success...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29042551/integrating-evolutionary-and-regulatory-information-with-a-multispecies-approach-implicates-genes-and-pathways-in-obsessive-compulsive-disorder
#16
Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O'Dushlaine, Ross Swofford, Daniel Howrigan, Diane P Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grünblatt, Erik Andersson, Diana R Djurfeldt, Paresh D Patel, Michele Koltookian, Christina M Hultman, Michele T Pato, Carlos N Pato, Steven A Rasmussen, Michael A Jenike, Gregory L Hanna, S Evelyn Stewart, James A Knowles, Stephan Ruhrmann, Hans-Jörgen Grabe, Michael Wagner, Christian Rück, Carol A Mathews, Susanne Walitza, Daniëlle C Cath, Guoping Feng, Elinor K Karlsson, Kerstin Lindblad-Toh
Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method that prioritizes likely functional variants, we compared 592 cases to 560 controls and found four strongly associated genes, validated in a larger cohort. NRXN1 and HTR2A are enriched for coding variants altering postsynaptic protein-binding domains...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29042190/hematopoietic-stem-progenitor-involvement-in-retinal-microvascular-repair-during-diabetes-implications-for-bone-marrow-rejuvenation
#17
Ashay D Bhatwadekar, Yaqian Duan, Maria Korahw, Jeffrey S Thinschmidt, Ping Hu, Sameer P Leley, Sergio Caballero, Lynn Shaw, Julia Busik, Maria B Grant
The widespread nature of diabetes affects all organ systems of an individual including the bone marrow. Long-term damage to the cellular and extracellular components of the bone marrow leads to a rapid decline in the bone marrow-hematopoietic stem/progenitor cells (HS/PCs) compartment. This review will highlight the importance of bone marrow microenvironment in maintaining bone marrow HS/PC populations and the contribution of these key populations in microvascular repair during the natural history of diabetes...
October 14, 2017: Vision Research
https://www.readbyqxmd.com/read/29041996/preparedness-training-programs-for-working-with-deaf-and-hard-of-hearing-communities-and-older-adults-lessons-learned-from-key-informants-and-literature-assessments
#18
Patricia W Kamau, Susan L Ivey, Stephanie E Griese, Shoukat H Qari
OBJECTIVES: The objectives of this study were to (1) identify available training programs for emergency response personnel and public health professionals on addressing the needs of Deaf and hard of hearing individuals and older adults, (2) identify strategies to improve these training programs, and (3) identify gaps in available training programs and make recommendations for addressing these gaps. METHODS: A literature review was conducted to identify relevant training programs and identify lessons learned...
October 18, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29041936/pathways-to-increased-coverage-an-analysis-of-time-trends-in-contraceptive-need-and-use-among-adolescents-and-young-women-in-kenya-rwanda-tanzania-and-uganda
#19
Mardieh L Dennis, Emma Radovich, Kerry L M Wong, Onikepe Owolabi, Francesca L Cavallaro, Michael T Mbizvo, Agnes Binagwaho, Peter Waiswa, Caroline A Lynch, Lenka Benova
BACKGROUND: Despite efforts to make contraceptive services more "youth friendly," unmet need for contraception among young women in sub-Saharan Africa remains high. For health systems to effectively respond to the reproductive health needs of a growing youth population, it is imperative to understand their contraceptive needs and service seeking practices. This paper describes changes over time in contraceptive need, use, and sources of care among young women in four East African countries...
October 17, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29040476/national-responses-to-global-health-targets-exploring-policy-transfer-in-the-context-of-the-unaids-90-90-90-treatment-targets-in-ghana-and-uganda
#20
Ellen McRobie, Fred Matovu, Aisha Nanyiti, Justice Nonvignon, Daniel Nana Yaw Abankwah, Kelsey K Case, Timothy B Hallett, Johanna Hanefeld, Lesong Conteh
Global health organizations frequently set disease-specific targets with the goal of eliciting adoption at the national-level; consideration of the influence of target setting on national policies, programme and health budgets is of benefit to those setting targets and those intended to respond. In 2014, the Joint United Nations Programme on HIV/AIDS set 'ambitious' treatment targets for country adoption: 90% of HIV-positive persons should know their status; 90% of those on treatment; 90% of those achieving viral suppression...
October 11, 2017: Health Policy and Planning
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