keyword
MENU ▼
Read by QxMD icon Read
search

Recent infection testing algorithm

keyword
https://www.readbyqxmd.com/read/28762652/hiv-incidence-in-the-estonian-population-in-2013-determined-using-the-hiv-1-limiting-antigen-avidity-assay
#1
P Soodla, R Simmons, K Huik, M Pauskar, E-L Jõgeda, H Rajasaar, E Kallaste, M Maimets, R Avi, G Murphy, K Porter, I Lutsar
OBJECTIVES: Estonia has one the highest number of new HIV diagnoses in the European Union, mainly among injecting drug users and heterosexuals. Little is known of HIV incidence, which is crucial for limiting the epidemic. Using a recent HIV infection testing algorithm (RITA) assay, we aimed to estimate HIV incidence in 2013. METHODS: All individuals aged ≥18 years newly-diagnosed with HIV in Estonia January- December 2013, except blood donors and those undergoing antenatal screening, were included...
August 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28737960/optimization-and-interpretation-of-serial-quantiferon-testing-to-measure-acquisition-of-m-tuberculosis-infection
#2
Elisa Nemes, Virginie Rozot, Hennie Geldenhuys, Nicole Bilek, Simbarashe Mabwe, Deborah Abrahams, Lebohang Makhethe, Mzwandile Erasmus, Alana Keyser, Asma Toefy, Yolundi Cloete, Frances Ratangee, Thomas Blauenfeldt, Morten Ruhwald, Gerhard Walzl, Bronwyn Smith, Andre G Loxton, Willem A Hanekom, Jason R Andrews, Maria D Lempicki, Ruth Ellis, Ann M Ginsberg, Mark Hatherill, Thomas J Scriba
RATIONALE: Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (M.tb) infection, which predisposes to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability. OBJECTIVES: To improve consistency of serial QuantiFERON-TB testing algorithms and provide a data-driven definition of conversion. METHODS: Sources of QuantiFERON-TB variability were assessed and optimal procedures identified...
July 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28691435/clinical-and-public-health-implications-of-acute-and-early-hiv-detection-and-treatment-a-scoping-review
#3
Sarah E Rutstein, Jintanat Ananworanich, Sarah Fidler, Cheryl Johnson, Eduard J Sanders, Omar Sued, Asier Saez-Cirion, Christopher D Pilcher, Christophe Fraser, Myron S Cohen, Marco Vitoria, Meg Doherty, Joseph D Tucker
INTRODUCTION: The unchanged global HIV incidence may be related to ignoring acute HIV infection (AHI). This scoping review examines diagnostic, clinical, and public health implications of identifying and treating persons with AHI. METHODS: We searched PubMed, in addition to hand-review of key journals identifying research pertaining to AHI detection and treatment. We focused on the relative contribution of AHI to transmission and the diagnostic, clinical, and public health implications...
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691129/preponderance-of-enterovirus-c-in-rd-l20b-cell-culture-negative-stool-samples-from-children-diagnosed-with-acute-flaccid-paralysis-in-nigeria
#4
J A Adeniji, A O Oragwa, U E George, U I Ibok, T O C Faleye, M O Adewumi
Recently, a reverse transcriptase semi-nested polymerase chain reaction (RT-snPCR) assay was recommended by the WHO for direct detection of enteroviruses in clinical specimens. In this study, we use this assay and a modification thereof to screen acute flaccid paralysis (AFP) samples that had previously tested negative for enteroviruses by the RD-L20B algorithm. Thirty paired stool suspensions collected in 2015 as part of the national AFP surveillance program in different states of Nigeria were analyzed in this study...
July 10, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28670965/false-recent-ratio-of-the-limiting-antigen-avidity-assay-and-viral-load-testing-algorithm-among-cameroonians-with-long-term-hiv-infection
#5
Briana A Lynch, Eshan U Patel, Colleen R Courtney, Aubin J Nanfack, Jude Bimela, Xiaohong Wang, Issa Eid, Thomas C Quinn, Oliver Laeyendecker, Phillipe N Nyambi, Ralf Duerr, Andrew D Redd
Current serological assays that are used for cross-sectional HIV incidence estimation have been shown to misclassify individuals with chronic infection. Limited information exists on the performance of cross-sectional incidence assays in Central Africa. HIV-positive individuals from Cameroon who were infected for at least 1 or 2 years were evaluated to determine the false recent ratio (FRR) of a two-assay algorithm, which includes the Limiting Antigen Avidity (LAg-Avidity) assay (normalized optical density units, ODn <1...
August 7, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28659319/laboratory-diagnosis-of-infective-endocarditis
#6
Rachael M Liesman, Bobbi S Pritt, Joseph J Maleszewski, Robin Patel
Infective endocarditis is life-threatening; identification of the underlying etiology informs optimized individual patient management. Changing epidemiology, advances in blood culture techniques, and new diagnostics guide the application of laboratory testing for diagnosis of endocarditis. Blood cultures remain the standard test for microbial diagnosis, with directed serological testing (i.e., Q fever serology, Bartonella serology) in culture-negative cases. Histopathology and molecular diagnostics (e.g., 16S ribosomal RNA gene PCR/sequencing, Trophyerma whipplei PCR) may be applied to resected valves to aid in diagnosis...
June 28, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28606812/novel-ctl-epitopes-identified-through-a-y-pestis-proteome-wide-analysis-in-the-search-for-vaccine-candidates-against-plague
#7
Anat Zvi, Shahar Rotem, Ayelet Zauberman, Uri Elia, Moshe Aftalion, Erez Bar-Haim, Emanuelle Mamroud, Ofer Cohen
The causative agent of Plague, Yersinia pestis, is a highly virulent pathogen and a potential bioweapon. Depending on the route of infection, two prevalent occurrences of the disease are known, bubonic and pneumonic. The latter has a high fatality rate. In the absence of a licensed vaccine, intense efforts to develop a safe and efficacious vaccine have been conducted, and humoral-driven subunit vaccines containing the F1 and LcrV antigens are currently under clinical trials. It is well known that a cellular immune response might have an essential additive value to immunity and protection against Y...
June 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28513998/inflammatory-bowel-disease-caused-by-primary-immunodeficiencies-clinical-presentations-review-of-literature-and-proposal-of-a-rational-diagnostic-algorithm
#8
REVIEW
Daniel Tegtmeyer, Maximilian Seidl, Patrick Gerner, Ulrich Baumann, Christian Klemann
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis have a multifactorial pathogenesis with complex interactions between polygenetic predispositions and environmental factors. However, IBD can also be caused by monogenic diseases, such as primary immunodeficiencies (PID). Recently, an increasing number of these altogether rare diseases have been described to present often primarily, or solely, as IBD. Early recognition of these conditions enables adaption of therapies and thus directly benefits the course of IBDs...
August 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28472089/performance-characteristics-of-an-antibody-based-multiplex-kit-for-determining-recent-hiv-1-infection
#9
Kelly A Curtis, Debra L Hanson, Krystin Ambrose Price, S Michele Owen
The availability of reliable laboratory methods for determining recent HIV infection is vital for accurate estimation of population-based incidence. The mean duration of recent infection (MDRI) and false recent rate (FRR) are critical parameters for HIV incidence assays, as they impact HIV incidence estimates and provide a measure of assay performance. The HIV-1 Multiplex assay is an in-house developed, magnetic bead-based assay that measures virus-specific antibody levels and avidity to multiple analytes. To ensure quality control and to facilitate transfer of the assay to external laboratories or testing facilities, the in-house assay has been adapted and produced in kit form...
2017: PloS One
https://www.readbyqxmd.com/read/28464021/predictive-value-of-clinical-and-laboratory-features-for-the-main-febrile-diseases-in-children-living-in-tanzania-a-prospective-observational-study
#10
Olga De Santis, Mary Kilowoko, Esther Kyungu, Willy Sangu, Pascal Cherpillod, Laurent Kaiser, Blaise Genton, Valérie D'Acremont
BACKGROUND: To construct evidence-based guidelines for management of febrile illness, it is essential to identify clinical predictors for the main causes of fever, either to diagnose the disease when no laboratory test is available or to better target testing when a test is available. The objective was to investigate clinical predictors of several diseases in a cohort of febrile children attending outpatient clinics in Tanzania, whose diagnoses have been established after extensive clinical and laboratory workup...
2017: PloS One
https://www.readbyqxmd.com/read/28434809/real-world-performance-of-the-new-us-hiv-testing-algorithm-in-medical-settings
#11
Kara G Marson, Robert Marlin, Phong Pham, Stephanie E Cohen, Diane Jones, Marguerite Roemer, Philip J Peters, Barbara Haller, Christopher D Pilcher
BACKGROUND: Our medical center laboratory recently adapted its 24/7, two-hourly testing program to use an ARCHITECT-Multispot-viral load (AR-MS-VL) algorithm in place of a previous rapid test-immunofluorescence (RT-IF) algorithm. OBJECTIVES: We evaluated screening test performance, acute case detection, turnaround time and ability to resolve HIV status under the new algorithm. STUDY DESIGN: We considered consecutive HIV tests from January to November 2015...
April 7, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28398683/update-on-syphilis-and-pregnancy
#12
REVIEW
Michael E Tsimis, Jeanne S Sheffield
While the origins of syphilis remain unknown, it has long been recognized as an infectious entity with complex pathophysiology. In this review, we highlighted the epidemiology and risk factors associated with syphilis. The incidence of syphilis in most populations showed a consistent upward trend until the 1940s with the introduction of penicillin as the preferred treatment. The emergence of congenital syphilis and vertical transmission has been a direct result of heterosexual syphilis transmission. We also explore the microbiology and pathogenesis of Treponema pallidum as it directly correlates with its route of transmission and infectivity...
March 15, 2017: Birth defects research
https://www.readbyqxmd.com/read/28291127/an-update-on-the-perioperative-management-of-children-with-upper-respiratory-tract-infections
#13
Adrian Regli, Karin Becke, Britta S von Ungern-Sternberg
PURPOSE OF REVIEW: This review summarizes the current evidence for the management of children with recent upper respiratory tract infections (URTIs). Furthermore, the review includes management guidelines for children with URTIs. RECENT FINDINGS: Good history and clinical examination is sufficient in most children presenting with URTI. Testing for immune markers or preoperative nitric oxide measurement does not add any additional value. Preoperative bronchodilator administration, intravenous induction with propofol, and noninvasive airway management all reduce the occurrence of respiratory adverse events...
June 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28283005/-comparison-of-maldi-tof-and-16s-rrna-methods-in-identification-of-viridans-group-streptococci
#14
Serap Süzük Yıldız, Banu Kaşkatepe, Salih Altınok, Mustafa Çetin, Alper Karagöz, Sümeyra Savaş
Accurate identification of viridans group streptococci (VGS) frequently encountered as a causative agent of infective endocarditis is always a challenge for the clinical microbiology laboratory. Clinical microbiology laboratories generally use semi automatic/full automatic systems, molecular methods and also conventional methods for the identification of these bacteria. There are recent published studies that have used MALDI-TOF (Matrix Assisted Laser Ionization Mass Spectrometry-Time of Flight) systems in the identification of VGS...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28155817/impact-of-the-genexpert-mtb-rif-technology-on-tuberculosis-control
#15
REVIEW
Wendy Susan Stevens, Lesley Scott, Lara Noble, Natasha Gous, Keertan Dheda
Molecular technology revolutionized the diagnosis of tuberculosis (TB) with a paradigm shift to faster, more sensitive, clinically relevant patient care. The most recent molecular leader is the GeneXpert MTB/RIF assay (Xpert) (Cepheid, Sunnyvale, CA), which was endorsed by the World Health Organization with unprecedented speed in December 2010 as the initial diagnostic for detection of HIV-associated TB and for where high rates of drug resistance are suspected. South Africa elected to take an aggressive smear replacement approach to facilitate earlier diagnosis and treatment through the decision to implement the Xpert assay nationally in March 2011, against the backdrop of approximately 6...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28107881/a-census-to-determine-the-prevalence-and-risk-factors-for-caprine-arthritis-encephalitis-virus-and-visna-maedi-virus-in-the-swiss-goat-population
#16
B Thomann, L C Falzon, G Bertoni, H R Vogt, G Schüpbach-Regula, I Magouras
In Switzerland, viruses belonging to two different phylogenetic groups of small ruminant lentiviruses (SRLV) are currently circulating: the caprine arthritis-encephalitis virus (CAEV) and visna/maedi virus (VMV). In the past two decades, a mandatory national control program has led to a very low prevalence of seropositivity, while completely eliminating CAE as a clinical manifestation. However, in order to reduce the high costs and effort associated with this program, adjustments based on the most recent epidemiological knowledge are needed...
February 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28077697/point-counterpoint-what-is-the-optimal-approach-for-detection-of-clostridium-difficile-infection
#17
Ferric C Fang, Christopher R Polage, Mark H Wilcox
INTRODUCTIONIn 2010, we published an initial Point-Counterpoint on the laboratory diagnosis of Clostridium difficile infection (CDI). At that time, nucleic acid amplification tests (NAATs) were just becoming commercially available, and the idea of algorithmic approaches to CDI was being explored. Now, there are numerous NAATs in the marketplace, and based on recent proficiency test surveys, they have become the predominant method used for CDI diagnosis in the United States. At the same time, there is a body of literature that suggests that NAATs lack clinical specificity and thus inflate CDI rates...
March 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28004622/moving-towards-a-reliable-hiv-incidence-test-current-status-resources-available-future-directions-and-challenges-ahead
#18
REVIEW
G Murphy, C D Pilcher, S M Keating, R Kassanjee, S N Facente, A Welte, E Grebe, K Marson, M P Busch, P Dailey, N Parkin, J Osborn, S Ongarello, K Marsh, J M Garcia-Calleja
In 2011 the Incidence Assay Critical Path Working Group reviewed the current state of HIV incidence assays and helped to determine a critical path to the introduction of an HIV incidence assay. At that time the Consortium for Evaluation and Performance of HIV Incidence Assays (CEPHIA) was formed to spur progress and raise standards among assay developers, scientists and laboratories involved in HIV incidence measurement and to structure and conduct a direct independent comparative evaluation of the performance of 10 existing HIV incidence assays, to be considered singly and in combinations as recent infection test algorithms...
April 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28002488/the-accuracy-of-diagnostic-tests-for-lyme-disease-in-humans-a-systematic-review-and-meta-analysis-of-north-american-research
#19
REVIEW
Lisa A Waddell, Judy Greig, Mariola Mascarenhas, Shannon Harding, Robbin Lindsay, Nicholas Ogden
There has been an increasing incidence of Lyme disease (LD) in Canada and the United States corresponding to the expanding range of the Ixodes tick vector and Lyme disease agent (Borrelia burgdorferi sensu stricto). There are many diagnostic tests for LD available in North America, all of which have some performance issues, and physicians are concerned about the appropriate use and interpretation of these tests. The objective of this systematic review is to summarize the North American evidence on the accuracy of diagnostic tests and test regimes at various stages of LD...
2016: PloS One
https://www.readbyqxmd.com/read/27956203/syphilis-during-pregnancy-a-preventable-threat-to-maternal-fetal-health
#20
REVIEW
Martha W F Rac, Paula A Revell, Catherine S Eppes
Syphilis remains the most common congenital infection worldwide and has tremendous consequences for the mother and her developing fetus if left untreated. Recently, there has been an increase in the number of congenital syphilis cases in the United States. Thus, recognition and appropriate treatment of reproductive-age women must be a priority. Testing should be performed at initiation of prenatal care and twice during the third trimester in high-risk patients. There are 2 diagnostic algorithms available and physicians should be aware of which algorithm is utilized by their testing laboratory...
April 2017: American Journal of Obstetrics and Gynecology
keyword
keyword
39530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"