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https://www.readbyqxmd.com/read/28211192/racial-differences-in-incident-de-novo-donor-specific-anti-hla-antibody-among-primary-renal-allograft-recipients
#1
Matthew J Everly, Kimberly P Briley, Carl E Haisch, Georg Dieplinger, Paul Bolin, Scott A Kendrick, Claire Morgan, Angela Q Maldonado, Lorita M Rebellato
Controversy exists as to whether African American (AA) transplant recipients are at risk for developing de novo donor-specific anti-human leukocyte antigen (HLA) antibody (dnDSA). We studied 341 HLA-mismatched, primary renal allograft recipients who were consecutively transplanted between 3/1999 and 12/2010. Sera were collected sequentially pre- and post-transplant and tested for anti-HLA immunoglobulin G (IgG) via single antigen bead assay. Of the 341 transplant patients (225 AA and 116 non-AA), 107 developed dnDSA at a median of 9...
February 17, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28209627/characterization-of-a-blood-spot-creatine-kinase-skeletal-muscle-isoform-immunoassay-for-high-throughput-newborn-screening-of-duchenne-muscular-dystrophy
#2
Stuart J Moat, Teemu Korpimäki, Petra Furu, Harri Hakala, Hanna Polari, Liisa Meriö, Pauliina Mäkinen, Ian Weeks
BACKGROUND: Duchenne muscular dystrophy (DMD) is a progressive, lethal X-linked neuromuscular disorder with an average worldwide incidence of 1:5000. Blood spot creatine kinase (CK) enzyme assays previously used in newborn screening programs for DMD are nonspecific because measured CK enzyme activity is attributable to 3 isoenzyme forms of CK (CK-MM, CK-MB, and CK-BB) and it is the CK-MM isoform that is found predominantly in skeletal muscle. CK-MM is increased in boys with DMD owing to muscle damage...
February 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28202059/cardiosphere-derived-cells-do-not-improve-cardiac-function-in-rats-with-cardiac-failure
#3
Taís Hanae Kasai-Brunswick, Andréa Rodrigues da Costa, Raiana Andrade Quintanilha Barbosa, Bruna Farjun, Fernanda Cristina Paccola Mesquita, Danúbia Silva Dos Santos, Isalira Peroba Ramos, Grazielle Suhett, Guilherme Visconde Brasil, Sandro Torrentes da Cunha, José Oscar R Brito, Juliana do Amaral Passipieri, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho
BACKGROUND: Heart failure represents an important public health issue due to its high costs and growing incidence worldwide. Evidence showing the regenerative potential of postmitotic heart tissue has suggested the existence of endogenous cardiac stem cells in adult hearts. Cardiosphere-derived cells (CDC) constitute a candidate pool of such cardiac stem cells. Previous studies using acute myocardial infarction (MI) models in rodents demonstrated an improvement in cardiac function after cell therapy with CDC...
February 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28198443/serum-lipid-alterations-identified-in-chronic-hepatitis-b-hepatitis-b-virus-associated-cirrhosis-and-carcinoma-patients
#4
Tao Wu, Xiaojiao Zheng, Ming Yang, Aihua Zhao, Meng Li, Tianlu Chen, Jun Panee, Wei Jia, Guang Ji
The incidences of chronic hepatitis B (CHB), Hepatitis B virus (HBV)-associated cirrhosis and HBV-associated carcinoma are high and increasing. This study was designed to evaluate serum lipid metabolite changes that are associated with the progression from CHB to HBV-associated cirrhosis and ultimately to HBV-associated HCC. A targeted metabolomic assay was performed in fasting sera from 136 CHB patients, 104 HBV-associated cirrhosis, and 95 HBV-associated HCC using ultra-performance liquid chromatography triple quadrupole mass spectrometry...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197738/vaccines-for-staphylococcus-aureus-and-target-populations
#5
Clarissa Pozzi, Reuben Olaniyi, Lassi Liljeroos, Ilaria Galgani, Rino Rappuoli, Fabio Bagnoli
Staphylococcus aureus is a leading pathogen in surgical site, intensive care unit, and skin infections, as well as healthcare-associated pneumonias. These infections are associated with an enormous burden of morbidity, mortality, and increase of hospital length of stay and patient cost. S. aureus is impressively fast in acquiring antibiotic resistance, and multidrug-resistant strains are a serious threat to human health. Due to resistance or insufficient effectiveness, antibiotics and bundle measures leave a tremendous unmet medical need worldwide...
February 15, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28197138/genetic-and-phenotypic-screening-of-mannose-binding-lectin-in-relation-to-risk-of-recurrent-vulvovaginal-infections-in-women-of-north-india-a-prospective-cohort-study
#6
Namarta Kalia, Jatinder Singh, Sujata Sharma, Hardesh Arora, Manpreet Kaur
Recurrent Vulvovaginal Infections (RVVI) is common problem associated with women of reproductive age. The function and deleterious effect of Mannose Binding Lectin 2 (MBL2) common polymorphisms are reported to be associated with various diseases. However, the role of MBL2 promoter gene polymorphisms and their combined effect with structural variant along with Serum Mannose Binding Lectin (sMBL) levels in RVVI has not been investigated. The study included 258 RVVI cases and 203 age matched healthy controls. These were investigated for the distribution of MBL2 codon 54 and promoter polymorphisms by Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28193746/dengue-virus-exposures-among-deployed-u-s-military-personnel
#7
Elisabeth M Hesse, Luis J Martinez, Richard G Jarman, Arthur G Lyons, Kenneth H Eckels, Rafael A De La Barrera, Stephen J Thomas
Dengue virus infections have adversely impacted U.S. military operations since the Spanish-American War. The erosion of mission capabilities and lost duty days are underestimated. Appreciating the incidence and prevalence of dengue infections in U.S. military personnel is important to inform disease prevention strategies. Banked pre- and post-deployment serum samples from 1,000 U.S. military personnel with a single deployment to a dengue-endemic region were tested using a screening microneutralization assay to detect anti-dengue-virus-neutralizing antibodies...
February 13, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28193090/estimating-false-recent-classification-for-the-limiting-antigen-avidity-eia-and-bed-capture-enzyme-immunoassay-in-vietnam-implications-for-hiv-1-incidence-estimates
#8
Neha S Shah, Yen T Duong, Linh-Vi Le, Nguyen Anh Tuan, Bharat Parekh, Hoang Thi Thanh Ha, Quang Duy Pham, Cao Thi Thu Cuc, Trudy Dobbs, Tran Hong Tram, Truong Tx Lien, Nick Wagar, Chunfu Yang, Amy Martin, Mitchell I Wolfe, Hien Tran Nguyen, Andrea A Kim
BACKGROUND: Laboratory tests that can distinguish recent from long-term HIV infection are used to estimate HIV incidence in a population but can potentially misclassify a proportion of long-term HIV infections as recent. Correct application of an assay requires determination of the proportion false recents (PFR) as part of the assay characterization and for calculating HIV incidence in a local population using a HIV incidence assay. METHODS: From April 2009 to December 2010, blood specimens were collected from HIV-infected individuals attending 9 outpatient clinics (OPCs) in Vietnam (4 from northern and 5 from southern Vietnam)...
February 14, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28192878/neuroprotective-effects-of-pretreatment-with-quercetin-as-assessed-by-acetylcholinesterase-assay-and-behavioral-testing-in-poloxamer-407-induced-hyperlipidemic-rats
#9
Josiane B S Braun, Jader B Ruchel, Stephen A Adefegha, Ana Paula V Coelho, Kelly B Trelles, Cristiane Signor, Maribel A Rubin, Juliana S Oliveira, Guilherme L Dornelles, Cinthia M de Andrade, Lívia G Castilhos, Daniela B R Leal
Hyperlipidemia is a group of disorders characterized by excessive lipids in the bloodstream. It is associated with the incidence of cardiovascular diseases and recognized as the most important factor underlying the occurrence of atherosclerosis. This study was conducted to investigate whether pretreatment with quercetin can protect against possible memory impairment and deterioration of the cholinergic system in hyperlipidemic rats. Animals were divided into ten groups (n=7): saline/control, saline/quercetin 5mg/kg, saline/quercetin 25mg/kg, saline/quercetin 50mg/kg, saline/simvastatin (0...
February 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28192050/evaluation-of-pcr-systems-for-field-screening-of-bacillus-anthracis
#10
Richard M Ozanich, Heather A Colburn, Kristin D Victry, Rachel A Bartholomew, Jennifer S Arce, Alejandro Heredia-Langner, Kristin Jarman, Helen W Kreuzer, Cynthia J Bruckner-Lea
There is little published data on the performance of hand-portable polymerase chain reaction (PCR) systems that can be used by first responders to determine if a suspicious powder contains a potential biothreat agent. We evaluated 5 commercially available hand-portable PCR instruments for detection of Bacillus anthracis. We used a cost-effective, statistically based test plan to evaluate systems at performance levels ranging from 0.85-0.95 lower confidence bound (LCB) of the probability of detection (POD) at confidence levels of 80% to 95%...
January 2017: Health Security
https://www.readbyqxmd.com/read/28188093/efficacy-of-epiphytic-bacteria-to-prevent-northern-leaf-blight-caused-by-exserohilum-turcicum-in-maize
#11
Melina Sartori, Andrea Nesci, Julián García, María A Passone, Analía Montemarani, Miriam Etcheverry
Eight potential biological control agents (BCAs) were evaluated in planta in order to assess their effectiveness in reducing disease severity of northern leaf blight caused by Exserohilum turcicum. The assay was carried out in greenhouse. Twenty-six-day-old plants, V4 phenological stage, were inoculated with antagonists by foliar spray. Only one biocontrol agent was used per treatment. Ten days after this procedure, all treatments were inoculated with E. turcicum by foliar application. Treatments performed were: C-Et: control of E...
February 7, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28187719/promotion-of-hepg2-cell-apoptosis-by-flower-of-allium-atroviolaceum-and-the-mechanism-of-action
#12
S Khazaei, R Abdul Hamid, N Mohd Esa, V Ramachandran, Ghomi Tabatabaee F Aalam, A Etemad, P Ismail
BACKGROUND: Liver cancer is a high incidence and fatal disease, the fifth most frequent cancer worldwide that is usually diagnosed at an advanced stage. The number of deaths from liver cancer has not declined even following various therapies. Plant secondary metabolites and their semi-synthetic derivatives play a principal role in anti-cancer drug therapy, since they are effective in the treatment of specific characteristics while also reducing side effects. Allium atroviolaceum, a plant of the genus Allium has been used in folk medicine to protect against several diseases...
February 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28186369/synthesis-and-mechanistic-studies-of-curcumin-analogs-based-oximes-as-potential-anticancer-agents
#13
Hua-Li Qin, Jing Leng, Bahaa G M Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Muhammad Ajaz Hussain, Zahid Hussain, Syeda Naveed Kazmi, Syed Nasir Abbas Bukhari
The incidence of cancer can be decreased by chemoprevention using either natural or synthetic agents. Apart from synthetic compounds, numerous natural products have exhibited promising potential to inhibit carcinogenesis in vivo. In this study, α, β-unsaturated carbonyl based anticancer compounds were used as starting materials to synthesize new oxime analogs. The findings from the antiproliferative assay using seven different human cancer cell lines provided a clear picture of structure-activity relationship...
February 10, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28185619/diagnosis-of-latent-tuberculosis-infection
#14
Alfred A Lardizabal, Lee B Reichman
For 2015, tuberculosis (TB) incidence in the United States has plateaued at 3.0 per 100,000. This remains the lowest case rate since recording started. On the global level, although the TB epidemic is larger than previously estimated, TB deaths and incidence rate continue to fall. For both low and high incidence countries, accelerating the decline in TB incidence towards elimination goals requires that more emphasis be placed on strengthening systems for detection and treatment of latent TB infection (LTBI) in addition to improving TB care globally...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28185617/mycobacterium-kansasii
#15
James C Johnston, Leslie Chiang, Kevin Elwood
The incidence of Mycobacterium kansasii varies widely over time and by region, but this organism remains one of the most clinically relevant isolated species of nontuberculous mycobacteria. In contrast to other common nontuberculous mycobacteria, M. kansasii is infrequently isolated from natural water sources or soil. The major reservoir appears to be tap water. Infection is likely acquired through the aerosol route, with low infectivity in regions of endemicity. Human-to-human transmission is thought not to occur...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28182079/immunocytoexpression-profile-of-proexc-in-smears-interpreted-as-asc-us-asc-h-and-cervical-intraepithelial-lesion
#16
Zeynep Tosuner, İlknur Türkmen, Sema Arici, Cavide Sönmez, Seval Turna, Öykü Onaran
AIMS: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears. SETTINGS AND DESIGN: Screening programs with Papanicolaou smear and high risk group human papilloma virus testing have yielded a dramatic reduction of cervical cancer incidence. However, both of these tests have limited specificity for the detection of clinically significant cervical high grade lesions...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28181380/fisetin-induced-apoptosis-of-human-oral-cancer-scc-4-cells-through-reactive-oxygen-species-production-endoplasmic-reticulum-stress-caspase-and-mitochondria-dependent-signaling-pathways
#17
Chen-Hsuan Su, Chao-Lin Kuo, Kung-Wen Lu, Fu-Shun Yu, Yi-Shih Ma, Jiun-Long Yang, Yung-Lin Chu, Fu-Shin Chueh, Kuo-Ching Liu, Jing-Gung Chung
Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer cells is still unclear; thus, in this study, we investigated fisetin-induced cell death and associated signal pathways on human oral cancer SCC-4 cells in vitro. We examined cell morphological changes, total viable cells, and cell cycle distribution by phase contrast microscopy and flow cytometry assays...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28178951/high-sensitive-c-reactive-protein-and-risk-of-incident-type-2-diabetes-a-case-control-study-nested-within-the-singapore-chinese-health-study
#18
An Pan, Yeli Wang, Jian-Min Yuan, Woon-Puay Koh
BACKGROUND: The liver-derived C-reactive protein (CRP) is a sensitive and systemic biomarker of inflammation, and has been associated with increased risk of developing type 2 diabetes in populations other than Chinese. Therefore, we prospectively examined the relation between plasma levels of CRP and risk of type 2 diabetes (T2D) among a Chinese population. METHODS: Plasma high-sensitive CRP (hs-CRP) concentrations were assayed among 571 T2D cases and 571 controls nested in the prospective cohort of the Singapore Chinese Health Study...
February 8, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28178632/impact-of-bioaccessibility-and-bioavailability-of-phenolic-compounds-in-biological-systems-upon-the-antioxidant-activity-of-the-ethanolic-extract-of-triplaris-gardneriana-seeds
#19
José Joaquim Lopes Neto, Thiago Silva de Almeida, Jackeline Lima de Medeiros, Leonardo Rogério Vieira, Thaís Borges Moreira, Ana Isabel Vitorino Maia, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Davi Felipe Farias, Ana Fontenele Urano Carvalho
The most studied bioactive potential of phenolic compounds corresponds to antioxidant activity, which in turn, is associated with a reduction in the incidence of various human diseases. However, the total quantity of these bioactive substances in foods and medicinal preparations does not reflect the amount absorbed and metabolized by the body. The present study aimed to investigate the bioaccessibility of Triplaris gardneriana seeds ethanolic extract (EETg) by determination of phenolic composition and antioxidant activities before and after in vitro digestion as well as to estimate its bioavailability by chemical analysis of plasma and urine in animal models after oral administration...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28176941/bioglass-implant-coating-interactions-in-synthetic-physiological-fluids-with-varying-degrees-of-biomimicry
#20
A C Popa, G E Stan, M A Husanu, I Mercioniu, L F Santos, H R Fernandes, Jmf Ferreira
Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid-implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorganic simulated body fluid. The advances in our knowledge point to the need of a true paradigm shift toward testing physiological fluids with enhanced biomimicry and a better understanding of the materials' structure-dissolution behavior...
2017: International Journal of Nanomedicine
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