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https://www.readbyqxmd.com/read/28646370/place-based-predictors-of-hiv-viral-suppression-and-durable-suppression-among-men-who-have-sex-with-men-in-new-york-city
#1
Kevin A Jefferson, Laura S Kersanske, Mary E Wolfe, Sarah L Braunstein, Regine Haardörfer, Don C Des Jarlais, Aimee N C Campbell, Hannah L F Cooper
We explore relationships between place characteristics and HIV viral suppression among HIV-positive men who have sex with men (MSM) in New York City (NYC). We conducted multilevel analyses to examine associations of United Hospital Fund (UHF)-level characteristics to individual-level suppression and durable suppression among MSM. Individual-level independent and dependent variables came from MSM in NYC's HIV surveillance registry who had been diagnosed in 2009-2013 (N = 7159). UHF-level covariates captured demographic composition, economic disadvantage, healthcare access, social disorder, and police stop and frisk rates...
June 23, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28646219/efficient-and-unbiased-metagenomic-recovery-of-rna-virus-genomes-from-human-plasma-samples
#2
Carmen F Manso, David F Bibby, Jean L Mbisa
RNA viruses cause significant human pathology and are responsible for the majority of emerging zoonoses. Mainstream diagnostic assays are challenged by their intrinsic diversity, leading to false negatives and incomplete characterisation. New sequencing techniques are expanding our ability to agnostically interrogate nucleic acids within diverse sample types, but in the clinical setting are limited by overwhelming host material and ultra-low target frequency. Through selective host RNA depletion and compensatory protocol adjustments for ultra-low RNA inputs, we are able to detect three major blood-borne RNA viruses - HIV, HCV and HEV...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645888/hiv-strategic-information-in-non-european-union-countries-in-the-world-health-organization-european-region-capacity-development-needs
#3
Ivana Bozicevic, Senad Handanagic, Jurja Ivana Cakalo, Annemarie Rinder Stengaard, George Rutherford
BACKGROUND: Capacity building of the national HIV strategic information system is a core component of the response to the HIV epidemic as it enables understanding of the evolving nature of the epidemic, which is critical for program planning and identification of the gaps and deficiencies in HIV programs. OBJECTIVE: The study aims to describe the results of the assessment of the needs for further development of capacities in HIV strategic information systems in the non-European Union (EU) countries in the World Health Organization European Region (EUR)...
June 23, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28641707/analysis-of-transmitted-hiv-drug-resistance-from-2005-to-2015-in-victoria-australia-a-comparison-of-the-old-and-the-new
#4
Jodie D'Costa, Megan Gooey, Nicole Richards, Rizmina Sameer, Elaine Lee, Doris Chibo
Background: Baseline genotyping is part of standard-of-care treatment. It reveals that transmitted drug resistance (TDR) continues to be important for the management of HIV infection. Attention is typically focused on determining whether resistance to the protease inhibitors (PI) and reverse transcriptase inhibitors (RTI) occurs. However, the increasing use of integrase inhibitors (INIs) raises a concern that TDR to this class of antiretroviral drug may also occur. Methods: PI and RTI drug resistance genotyping was performed on blood samples collected between 2005 and 2015 from 772 treatment-naïve Victorian patients infected with HIV within the previous 12 months...
June 23, 2017: Sexual Health
https://www.readbyqxmd.com/read/28637724/cross-sectional-association-between-zip-code-level-gentrification-and-homelessness-among-a-large-community-based-sample-of-people-who-inject-drugs-in-19-us-cities
#5
Sabriya L Linton, Hannah Lf Cooper, Mary E Kelley, Conny C Karnes, Zev Ross, Mary E Wolfe, Samuel R Friedman, Don Des Jarlais, Salaam Semaan, Barbara Tempalski, Catlainn Sionean, Elizabeth DiNenno, Cyprian Wejnert, Gabriela Paz-Bailey
BACKGROUND: Housing instability has been associated with poor health outcomes among people who inject drugs (PWID). This study investigates the associations of local-level housing and economic conditions with homelessness among a large sample of PWID, which is an underexplored topic to date. METHODS: PWID in this cross-sectional study were recruited from 19 large cities in the USA as part of National HIV Behavioral Surveillance. PWID provided self-reported information on demographics, behaviours and life events...
June 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28636590/host-and-viral-traits-predict-zoonotic-spillover-from-mammals
#6
Kevin J Olival, Parviez R Hosseini, Carlos Zambrana-Torrelio, Noam Ross, Tiffany L Bogich, Peter Daszak
The majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, HIV, Ebola and SARS). Understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. However, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species boundaries. Here we conduct a comprehensive analysis of mammalian host-virus relationships and show that both the total number of viruses that infect a given species and the proportion likely to be zoonotic are predictable...
June 21, 2017: Nature
https://www.readbyqxmd.com/read/28634152/ensuring-inclusion-of-adolescent-key-populations-at-higher-risk-of-hiv-exposure-recommendations-for-conducting-biological-behavioral-surveillance-surveys
#7
Lisa Grazina Johnston, Justine Sass, Jeffry Acaba, Wing-Sie Cheng, Shirley Mark Prabhu
Ending acquired immune deficiency syndrome (AIDS) depends on greater efforts to reduce new human immunodeficiency virus (HIV) infections and prevent AIDS-related deaths among key populations at highest HIV risk, including males who have sex with males, sex workers, and people who inject drugs. Although adolescent key populations (AKP) are disproportionately affected by HIV, they have been largely ignored in HIV biological behavioral surveillance survey (BBSS) activities to date. This paper reviews current ethical and sampling challenges and provides suggestions to ensure AKP are included in surveillance activities, with the aim being to enhance evidence-informed, strategic, and targeted funding allocations and programs toward ending AIDS among AKP...
June 20, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28633734/cutaneous-hiv-associated-kaposi-sarcoma-a-potential-setting-for-management-by-clinical-observation
#8
Surget V Beatrous, Stratton B Grisoli, Ryan R Riahi, Philip R Cohen
Kaposi sarcoma (KS) is a malignancy of viral etiology whose course ranges from cutaneous limited lesions to fulminant disease with multi-organ involvement. Four clinical variants of the disease exist: classic, endemic, iatrogenic, and epidemic. Iatrogenic and epidemic variants of Kaposi sarcoma develop in the setting of immune suppression. Transplant recipients who develop iatrogenic KS typically demonstrate improvement of lesions following de-escalation of immunosuppressive therapy. Similarly, HIV-infected patients who begin highly active antiretroviral therapy (HAART) experience immune reconstitution, which can induce KS regression...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28631059/trends-in-hiv-risk-testing-and-treatment-among-msm-in-chicago-2004-2014-implications-for-hiv-elimination-planning
#9
Ethan Morgan, Britt Skaathun, Nicola Lancki, Antonio D Jimenez, Jesus Ramirez-Valles, Ramona Bhatia, Stephanie Masiello-Schuette, Nanette Benbow, Nikhil Prachand, John A Schneider
Men who have sex with men (MSM) in the USA continue to have high rates of HIV infection. Increasingly, in addition to behavioral factors, biomedical interventions have been found to play important roles in HIV prevention. In this analysis, we used four waves of cross-sectional data (2004, 2008, 2011, and 2014) from the National HIV Behavioral Surveillance System (NHBS) to examine trends in key behaviors and biomedical interventions among MSM in Chicago (N = 3298). Logistic regression was used to determine changes in behaviors and use of biomedical interventions...
June 19, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28628702/financial-incentives-for-linkage-to-care-and-viral-suppression-among-hiv-positive-patients-a-randomized-clinical-trial-hptn-065
#10
Wafaa M El-Sadr, Deborah Donnell, Geetha Beauchamp, H Irene Hall, Lucia V Torian, Barry Zingman, Garret Lum, Michael Kharfen, Richard Elion, Jason Leider, Fred M Gordin, Vanessa Elharrar, David Burns, Allison Zerbe, Theresa Gamble, Bernard Branson
Importance: Achieving linkage to care and viral suppression in human immunodeficiency virus (HIV)-positive patients improves their well-being and prevents new infections. Current gaps in the HIV care continuum substantially limit such benefits. Objective: To evaluate the effectiveness of financial incentives on linkage to care and viral suppression in HIV-positive patients. Design, Setting, and Participants: A large community-based clinical trial that randomized 37 HIV test and 39 HIV care sites in the Bronx, New York, and Washington, DC, to financial incentives or standard of care...
June 19, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28628667/characterization-of-hiv-1-crf90_bf1-and-putative-novel-crfs_bf1-in-central-west-north-and-northeast-brazilian-regions
#11
Mônica Nogueira da Guarda Reis, Gonzalo Bello, Monick Lindenmeyer Guimarães, Mariane Martins Araújo Stefani
The Brazilian AIDS epidemic has been characterized by an increasing rate of BF1 recombinants and so far eight circulating recombinant forms/CRFs_BF1 have been described countrywide. In this study, pol sequences (protease/PR, reverse transcriptase/RT) of 87 BF1 mosaic isolates identified among 828 patients living in six Brazilian States from three geographic regions (Central West, North, Northeast) were analyzed. Phylogenetic and bootscan analyses were performed to investigate the evolutionary relationship and mosaic structure of BF1 isolates...
2017: PloS One
https://www.readbyqxmd.com/read/28627929/design-of-the-hptn-065-tlc-plus-study-a-study-to-evaluate-the-feasibility-of-an-enhanced-test-link-to-care-plus-treat-approach-for-hiv-prevention-in-the-united-states
#12
Theresa Gamble, Bernard Branson, Deborah Donnell, H Irene Hall, Georgette King, Blayne Cutler, Shannon Hader, David Burns, Jason Leider, Angela Fulwood Wood, Kevin G Volpp, Kate Buchacz, Wafaa M El-Sadr
Background/Aims HIV continues to be a major public health threat in the United States, and mathematical modeling has demonstrated that the universal effective use of antiretroviral therapy among all HIV-positive individuals (i.e. the "test and treat" approach) has the potential to control HIV. However, to accomplish this, all the steps that define the HIV care continuum must be achieved at high levels, including HIV testing and diagnosis, linkage to and retention in clinical care, antiretroviral medication initiation, and adherence to achieve and maintain viral suppression...
June 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28604445/development-of-an-hiv-testing-dashboard-to-complement-the-hiv-care-continuum-among-msm-pwid-and-heterosexuals-in-washington-dc-2007-2015
#13
Rudy Patrick, Alan Greenberg, Manya Magnus, Jenevieve Opoku, Michael Kharfen, Irene Kuo
BACKGROUND: We developed an HIV testing dashboard to complement the HIV care continuum in selected high-risk populations. Using National HIV Behavioral Surveillance (NHBS) data, we examined trends in HIV testing and care for men who have sex with men (MSM), persons who inject drugs (PWID), and heterosexuals at elevated risk (HET). METHODS: Between 2007 and 2015, 4792 participants ≥18 years old completed a behavioral survey and were offered HIV testing. For the testing dashboard, proportions ever tested, tested in the past year, testing HIV-positive, and newly testing positive were calculated...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604444/antiretroviral-therapy-use-among-hiv-infected-people-who-inject-drugs-20-cities-united-states-2009-2015
#14
Brooke E Hoots, Teresa J Finlayson, Dita Broz, Gabriela Paz-Bailey
BACKGROUND: Approximately 16% of infections among those living with diagnosed HIV infection in the United States are attributable to injection drug use. Antiretrovirals (ARVs) are recommended for all infected persons to improve health and prevent transmission. Using data from National HIV Behavioral Surveillance, we evaluated changes in ARV use from 2009 to 2015 among HIV-positive people who inject drugs (PWID). METHODS: PWID were recruited by respondent-driven sampling in 20 cities...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604443/differences-in-awareness-of-pre-exposure-prophylaxis-and-post-exposure-prophylaxis-among-groups-at-risk-for-hiv-in-new-york-state-new-york-city-and-long-island-ny-2011-2013
#15
Suzan M Walters, Alexis V Rivera, Lila Starbuck, Kathleen H Reilly, Nyasha Boldon, Bridget J Anderson, Sarah Braunstein
BACKGROUND: Pre-exposure prophylaxis (PrEP) to reduce the risk of HIV was approved in 2012 and post-exposure prophylaxis (PEP) in 2005. We report the differences in awareness of PrEP/PEP and factors associated with awareness by examining 3 risk groups (men who have sex with men (MSM), people who inject drugs, and high-risk heterosexuals). METHODS: National HIV Behavioral Surveillance system data collected in New York City (NYC) and Long Island, NY in 2011-2013 were used...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604442/awareness-willingness-and-use-of-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-in-washington-dc-and-miami-dade-county-fl-national-hiv-behavioral-surveillance-2011-and-2014
#16
Rudy Patrick, David Forrest, Gabriel Cardenas, Jenevieve Opoku, Manya Magnus, Gregory Phillips, Alan Greenberg, Lisa Metsch, Michael Kharfen, Marlene LaLota, Irene Kuo
INTRODUCTION: Despite the effectiveness of oral pre-exposure prophylaxis (PrEP) for HIV prevention, knowledge, and uptake of this new prevention intervention over time has not been fully studied. Using NHBS data from 2 urban areas highly impacted by HIV, we examined awareness, use, and willingness to use daily oral PrEP and factors associated with willingness to take oral PrEP among men who have sex with men (MSM) over time. METHODS: MSM from Washington, DC and Miami, FL were recruited in 2011 and 2014 using venue-based sampling...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604441/increasing-human-papillomavirus-vaccine-coverage-among-men-who-have-sex-with-men-national-hiv-behavioral-surveillance-united-states-2014
#17
Sara E Oliver, Brooke E Hoots, Gabriela Paz-Bailey, Lauri E Markowitz, Elissa Meites
BACKGROUND: Human papillomavirus (HPV) can cause oropharyngeal and anogenital cancers among men who have sex with men (MSM). In 2011, the Advisory Committee on Immunization Practices (ACIP) extended HPV vaccine recommendations to males through age 21 and MSM through age 26. Because of this distinction, vaccination for some MSM might rely on sexual behavior disclosure to health care providers. Receipt of ≥1 HPV vaccination among MSM aged 18-26 in National HIV Behavioral Surveillance (NHBS) was 4...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604440/syphilis-screening-and-diagnosis-among-men-who-have-sex-with-men-2008-2014-20-u-s-cities
#18
Qian An, Cyprian Wejnert, Kyle Bernstein, Gabriela Paz-Bailey
BACKGROUND: Annual screening for syphilis is indicated for all sexually active men who have sex with men (MSM). METHODS: Using National HIV Behavioral Surveillance data from 2008, 2011, and 2014, we assessed trends in self-reported syphilis testing and diagnoses in the past 12 months among MSM. We calculated percentages of syphilis screening and diagnosis by selected characteristics for each year. Trends were assessed using Poisson regression models with generalized estimation equations...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604438/preferences-for-home-based-hiv-testing-among-heterosexuals-at-increased-risk-for-hiv-aids-new-orleans-louisiana-2013
#19
William T Robinson, Meagan Zarwell, DeAnn Gruber
Participants in the New Orleans arm of the National HIV Behavioral Surveillance of Heterosexuals at Increased Risk for HIV were asked about potential utilization of self-administered home-based tests for HIV. The majority (86%) would use a free home-based test if provided by mail and 99% would seek treatment based on a positive result. In addition, more than half of respondents would return test results in some format to the test provider, whereas most of the remaining participants preferred to discuss results only with their doctor...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604437/a-decline-in-hiv-testing-among-persons-who-inject-drugs-in-the-seattle-area-2004-2015
#20
Richard D Burt, Joe Tinsley, Sara Nelson Glick
BACKGROUND: Promoting HIV testing is a key component of the public health response to HIV. Assessing HIV testing frequency among persons who inject drugs (PWID) monitors the status of these efforts and can identify unmet needs and opportunities to more effectively promote testing. METHODS: Data were combined from 4 Seattle-area surveys of PWID from the National HIV Behavioral Surveillance (NHBS) program (2005-2015) and 6 surveys of Needle Exchange clients (2004-2015)...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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