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https://www.readbyqxmd.com/read/27770643/1h-magnetic-resonance-spectroscopy-study-of-glutamate-related-abnormality-in-bipolar-disorder
#1
Hiroko Kubo, Masahito Nakataki, Satsuki Sumitani, Jun-Ichi Iga, Shusuke Numata, Naomi Kameoka, Shin-Ya Watanabe, Hidehiro Umehara, Makoto Kinoshita, Masatoshi Inoshita, Mai Tamaru, Masashi Ohta, Chiaki Nakayama-Yamauchi, Yasuhiro Funakoshi, Masafumi Harada, Tetsuro Ohmori
BACKGROUND: Previous studies of patients with bipolar disorder (BD) using magnetic resonance spectroscopy (MRS) have shown neurophysiological abnormalities related to the glutamate (Glu)-glutamine (Gln) cycle, membrane turnover, and neuronal integrity, although the results were neither consistent nor conclusive. Recently it has been reported the Gln/Glu ratio is the most useful index, quantifying neuronal-glial interactions and the balance of glutamatergic metabolites In this MRS study, we elucidated the abnormalities of metabolites in a larger sample of patients with BD with a high-field MRI system...
October 8, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27609245/postpartum-psychosis-madness-mania-and-melancholia-in-motherhood
#2
Veerle Bergink, Natalie Rasgon, Katherine L Wisner
OBJECTIVE: Psychosis or mania after childbirth is a psychiatric emergency with risk for suicide and infanticide. METHOD: The authors reviewed the epidemiologic and genetic research and physiological postpartum triggers (endocrine, immunological, circadian) of psychosis. They also summarized all systematic reviews and synthesized the sparse clinical studies to provide diagnostic recommendations, treatment options, and strategies for prevention. RESULTS: The incidence of first-lifetime onset postpartum psychosis/mania from population-based register studies of psychiatric admissions varies from 0...
December 1, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27500978/midazolam-ketamine-dual-therapy-stops-cholinergic-status-epilepticus-and-reduces-morris-water-maze-deficits
#3
Jerome Niquet, Roger Baldwin, Keith Norman, Lucie Suchomelova, Lucille Lumley, Claude G Wasterlain
OBJECTIVE: Pharmacoresistance remains an unsolved therapeutic challenge in status epilepticus (SE) and in cholinergic SE induced by nerve agent intoxication. SE triggers a rapid internalization of synaptic γ-aminobutyric acid A (GABAA ) receptors and externalization of N-methyl-d-aspartate (NMDA) receptors that may explain the loss of potency of standard antiepileptic drugs (AEDs). We hypothesized that a drug combination aimed at correcting the consequences of receptor trafficking would reduce SE severity and its long-term consequences...
September 2016: Epilepsia
https://www.readbyqxmd.com/read/27495218/status-epilepticus-alters-hippocampal-long-term-synaptic-potentiation-in-a-rat-lithium-pilocarpine-model
#4
Kirill A Kryukov, Kira K Kim, Lev G Magazanik, Aleksey V Zaitsev
Seizure-induced memory deficits are frequent in patients with temporal lobe epilepsy. However, the neural mechanisms responsible for this memory impairment are not entirely clear. Persistent changes in synaptic efficacy, long-term potentiation (LTP), and depression are considered a cellular substrate underlying the learning and memory processes. Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE...
November 9, 2016: Neuroreport
https://www.readbyqxmd.com/read/27444804/estimation-of-the-imprecision-on-clinical-chemistry-testing-due-to-fist-clenching-and-maintenance-during-venipuncture
#5
Gabriel Lima-Oliveira, Gian Cesare Guidi, Gian Luca Salvagno, Giorgio Brocco, Elisa Danese, Giuseppe Lippi
OBJECTIVES: An experimental study was planned to assess the influence on routine clinical chemistry parameters of fist making prior to, and maintenance during, venipuncture. DESIGN AND METHODS: Blood was collected from 16 healthy volunteers with two separate sequential procedures, entailing standard venipuncture with hand opened throughout blood collection, or clenching the fist 6 times before venipuncture and maintaining the fist until completion of blood collection...
December 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27216588/catatonic-syndrome-from-detection-to-therapy
#6
J Madigand, P Lebain, G Callery, S Dollfus
INTRODUCTION: Catatonia is a psychomotor syndrome which can include motor, mental, behavioral and vegetative symptoms. Exclusively associated with schizophrenia until the 1970s, catatonia still remains an under-diagnosed syndrome with significant morbidity and mortality. LITERATURE FINDINGS: As a result of its different forms and developments, catatonic syndrome can be associated with many organic and psychiatric etiologies and confused with a variety of diagnoses...
August 2016: L'Encéphale
https://www.readbyqxmd.com/read/27197133/quality-performance-of-laboratory-testing-in-pharmacies-a-collaborative-evaluation
#7
Martina Zaninotto, Giorgia Miolo, Adriano Guiotto, Silvia Marton, Mario Plebani
BACKGROUND: The quality performance and the comparability between results of pharmacies point-of-care-testing (POCT) and institutional laboratories have been evaluated. METHODS: Eight pharmacies participated in the project: a capillary specimen collected by the pharmacist and, simultaneously, a lithium-heparin sample drawn by a physician of laboratory medicine for the pharmacy customers (n=106) were analyzed in the pharmacy and in the laboratory, respectively. Glucose, cholesterol, HDL-cholesterol, triglycerides, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, were measured using: Reflotron, n=5; Samsung, n=1; Cardiocheck PA, n=1; Cholestech LDX, n=1 and Cobas 8000...
May 19, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27188468/the-role-of-gastrodin-on-hippocampal-neurons-after-n-methyl-d-aspartate-excitotoxicity-and-experimental-temporal-lobe-seizures
#8
Shi-Bing Wong, Wei-Chen Hung, Ming-Yuan Min
Tian ma (Gastrodia elata, GE) is an ancient Chinese herbal medicine that has been suggested to be effective as an anticonvulsant and analgesic, and to have sedative effects against vertigo, general paralysis, epilepsy and tetanus. The primary active ingredient isolated from GE is termed gastrodin, which is the glucoside of 4-hydroxybenzyl alcohol (4-HBA). Gastrodin can abolish hypoxia-, glutamate- and N-methyl-D-aspartate (NMDA) receptor-induced toxicity in primary culture of rat cortical neurons, and reduces seizure severity in seizure-sensitive gerbils...
June 30, 2016: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/26894301/mitochondrial-dysfunction-and-lipid-peroxidation-in-rat-frontal-cortex-by-chronic-nmda-administration-can-be-partially-prevented-by-lithium-treatment
#9
Helena K Kim, Cameron Isaacs-Trepanier, Nika Elmi, Stanley I Rapoport, Ana C Andreazza
Chronic N-methyl-d-aspartate (NMDA) administration to rats may be a model to investigate excitotoxicity mediated by glutamatergic hyperactivity, and lithium has been reported to be neuroprotective. We hypothesized that glutamatergic hyperactivity in chronic NMDA injected rats would cause mitochondrial dysfunction and lipid peroxidation in the brain, and that chronic lithium treatment would ameliorate some of these NMDA-induced alterations. Rats treated with lithium for 6 weeks were injected i.p. 25 mg/kg NMDA on a daily basis for the last 21 days of lithium treatment...
May 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/26807672/an-assessment-of-the-anti-fatigue-effects-of-ketamine-from-a-double-blind-placebo-controlled-crossover-study-in-bipolar-disorder
#10
Leorey N Saligan, David A Luckenbaugh, Elizabeth E Slonena, Rodrigo Machado-Vieira, Carlos A Zarate
BACKGROUND: Fatigue is a multidimensional condition that is difficult to treat with standard monoaminergic antidepressants. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist produces rapid and robust improvements in depressive symptoms in treatment-resistant depression. However, there is a dearth of literature examining the anti-fatigue effects of ketamine. We hypothesize that ketamine will rapidly improve fatigue symptoms in treatment-resistant depressed patients. METHODS: This is an exploratory analysis of data obtained from two double-blind, randomized, placebo-controlled, crossover trials...
April 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26688426/n-methyl-d-aspartate-receptor-nr2b-subunit-involved-in-depression-like-behaviours-in-lithium-chloride-pilocarpine-chronic-rat-epilepsy-model
#11
Wei-Feng Peng, Jing Ding, Xin Li, Fan Fan, Qian-Qian Zhang, Xin Wang
Depression is a common comorbidity in patients with epilepsy with unclear mechanisms. This study is to explore the role of glutamate N-methyl-D-aspartate (NMDA) receptor NR1, NR2A and NR2B subunits in epilepsy-associated depression. Lithium chloride (Licl)-pilocarpine chronic rat epilepsy model was established and rats were divided into epilepsy with depression (EWD) and epilepsy without depression (EWND) subgroups based on forced swim test. Expression of NMDA receptor NR1, NR2A and NR2B subunits was measured by western blot and immunofluorescence methods...
January 2016: Epilepsy Research
https://www.readbyqxmd.com/read/26327310/mammalian-csad-and-gadl1-have-distinct-biochemical-properties-and-patterns-of-brain-expression
#12
Ingeborg Winge, Knut Teigen, Agnete Fossbakk, Elaheh Mahootchi, Rune Kleppe, Filip Sköldberg, Olle Kämpe, Jan Haavik
Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have been proposed to be involved in the pyridoxal-5'-phosphate (PLP)-dependent biosynthesis of taurine. In the present study, we compared the catalytic properties, inhibitor sensitivity and expression profiles of GADL1 and CSAD in brain tissue. In mouse and human brain we observed distinct patterns of expression of the PLP-dependent decarboxylases CSAD, GADL1 and glutamic acid decarboxylase 67 (GAD67)...
November 2015: Neurochemistry International
https://www.readbyqxmd.com/read/26248944/phosphatase-inhibition-prevents-the-activity-dependent-trafficking-of-gabaa-receptors-during-status-epilepticus-in-the-young-animal
#13
Suchitra Joshi, Karthik Rajasekaran, Kyle M Hawk, Jasmit Brar, Brittany M Ross, Christine A Tran, Stephen J Chester, Howard P Goodkin
OBJECTIVES: To determine if the activity-dependent trafficking of γ2 subunit-containing γ-aminobutyric acid type A receptors (GABAA Rs) that has been observed in older animals and posited to contribute to benzodiazepine pharmacoresistance during status epilepticus (SE) is age-dependent, and to evaluate whether blockade of protein phosphatases can inhibit or reverse the activity-dependent plasticity of these receptors. METHODS: The efficacy and potency of diazepam 0...
September 2015: Epilepsia
https://www.readbyqxmd.com/read/26096168/mild-alcohol-intake-exacerbates-metabolic-syndrome-in-rodents-a-putative-role-of-gsk-3%C3%AE
#14
Yamini Chauhan, Rohit Goyal, Shaila Khah, Pyare Lal Sharma
Metabolic syndrome is characterized with abdominal obesity, insulin resistance, dyslipidemia and hepatic dysfunction. Glycogen synthase kinase-3β (GSK-3β) expression has been observed in adipose tissues in obese and diabetic humans, and in rodents. The aim of study was to investigate role of GSK-3β in modulation of metabolic alterations in alcoholic fed rats. Male Wistar albino rats (180-220 g) were used. High fat diet (HFD) for 8 weeks and alcohol (2%) from third to eighth week were given. Lithium chloride (LiCl), a GSK-3β inhibitor (60 mg/kg) was used orally from third to eighth week...
2015: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/26092248/mice-heterozygous-for-cathepsin-d-deficiency-exhibit-mania-related-behavior-and-stress-induced-depression
#15
Rui Zhou, Yi Lu, Yong Han, Xia Li, Huifang Lou, Liya Zhu, Xuechu Zhen, Shumin Duan
Mutations in cathepsin D (CTSD), an aspartic protease in the endosomal-lysosomal system, underlie congenital neuronal ceroid-lipofuscinosis (cNCL, also known as CLN10), a devastating neurodegenerative disease. CLN10 patients die within the first few days of life, and in the few patients who live into adulthood psychopathological symptoms have not been reported. Extensive neuropathology and altered neurotransmission have been reported in CTSD-deficient mice; however signs of neuropsychiatric behavior in these mice are not well characterized due to the severe movement disorder and premature death of the animal...
December 3, 2015: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/25888981/liver-function-testing-on-the-abaxis-piccolo-xpress-use-in-ebola-virus-disease-protocols
#16
William E Owen, Justin E Caron, Jonathan R Genzen
BACKGROUND: Laboratories that choose a point-of-care approach for liver function testing in patients undergoing evaluation for Ebola virus disease (EVD) have few options to choose from. The primary objective of this study was to conduct a performance characterization of a Clinical Laboratory Improvement Amendments (CLIA)-waived liver function panel on the Abaxis Piccolo® Xpress chemistry analyzer. The secondary objectives were to evaluate multiple specimen types, characterize whole blood specimen stability, and validate disposable exact transfer pipettes...
June 15, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/25650685/three-year-naturalistic-mirror-image-assessment-of-adding-memantine-to-the-treatment-of-30-treatment-resistant-patients-with-bipolar-disorder
#17
Giulia Serra, Athanasios Koukopoulos, Lavinia De Chiara, Alexia E Koukopoulos, Leonardo Tondo, Paolo Girardi, Ross J Baldessarini, Gino Serra
BACKGROUND: Developing safe and effective long-term treatments for bipolar disorder remains a major challenge. Given available treatments, patients with bipolar disorder remain unwell in half of long-term follow-up, mostly in depression. As memantine, an N-methyl-D-aspartate (NMDA)-glutamate receptor antagonist used to treat dementia, has been proposed for testing in bipolar disorder, we carried out a 3 + 3-year, mirror-image, chart-review study of the effects of adding memantine to stably continued, but insufficiently effective, ongoing mood-stabilizing treatments...
January 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/25536048/neuroprotective-effect-of-hemeoxygenase-1-glycogen-synthase-kinase-3%C3%AE-modulators-in-3-nitropropionic-acid-induced-neurotoxicity-in-rats
#18
A Khan, S Jamwal, K R V Bijjem, A Prakash, P Kumar
The present study has been designed to explore the possible interaction between hemeoxygenase-1 (HO-1) and glycogen synthase kinase-3β (GSK-3β) pathway in 3-nitropropionic acid (3-NP)-induced neurotoxicity in rats. 3-NP produces neurotoxicity by inhibition of the mitochondrial complex II (enzyme succinate dehydrogenase) and by sensitizing the N-methyl-D-aspartate receptor. Recent studies have reported the therapeutic potential of HO-1/GSK-3β modulators in different neurodegenerative disorders. However, their exact role is yet to be explored...
February 26, 2015: Neuroscience
https://www.readbyqxmd.com/read/25534739/protection-against-klebsiella-pneumoniae-using-lithium-chloride-in-an-intragastric-infection-model
#19
Nina Tsao, Chih-Feng Kuo, Ching-Chen Chiu, Wei-Chen Lin, Wan-Hui Huang, Li-Yang Chen
Intragastric Klebsiella pneumoniae infections of mice can cause liver abscesses, necrosis of liver tissues, and bacteremia. Lithium chloride, a widely prescribed drug for bipolar mood disorder, has been reported to possess anti-inflammatory properties. Using an intragastric infection model, the effects of LiCl on K. pneumoniae infections were examined. Providing mice with drinking water containing LiCl immediately after infection protected them from K. pneumoniae-induced death and liver injuries, such as necrosis of liver tissues, as well as increasing blood levels of aspartate aminotransferase and alanine aminotransferase, in a dose-dependent manner...
March 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/25522399/bimodal-effect-of-lithium-plasma-levels-on-hippocampal-glutamate-concentrations-in-bipolar-ii-depression-a-pilot-study
#20
Marcus V Zanetti, Maria C Otaduy, Rafael T de Sousa, Wagner F Gattaz, Geraldo F Busatto, Claudia C Leite, Rodrigo Machado-Vieira
BACKGROUND: The hippocampus has been highly implicated in the pathophysiology of bipolar disorder (BD). Nevertheless, no study has longitudinally evaluated hippocampal metabolite levels in bipolar depression under treatment with lithium. METHODS: Nineteen medication-free BD patients (78.9% treatment-naïve and 73.7% with BD type II) presenting an acute depressive episode and 17 healthy controls were studied. Patients were treated for 6 weeks with lithium in an open-label trial...
April 2015: International Journal of Neuropsychopharmacology
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