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https://www.readbyqxmd.com/read/28645969/protocol-for-the-residents-in-action-pilot-cluster-randomised-controlled-trial-riat-evaluating-a-behaviour-change-intervention-to-promote-walking-reduce-sitting-and-improve-mental-health-in-physically-inactive-older-adults-in-retirement-villages
#1
Cecilie Thøgersen-Ntoumani, Ashlene Wright, Eleanor Quested, Elissa Burton, Keith D Hill, Ester Cerin, Stuart J H Biddle, Nikos Ntoumanis
INTRODUCTION: Ageing is accompanied by increased risks of chronic disease, declined functioning and increased dependency. Physical activity is critical to retaining health and independence, but the majority of older people are insufficiently physically active to achieve these benefits and have high levels of sedentary (sitting) time. Activity programmes are often offered in retirement villages; however, their uptake is limited. Furthermore, although the physical environment in and around these villages can play an important role in decisions to be physically active, its role is often overlooked by research in these settings...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28643221/post-exercise-blood-flow-restriction-attenuates-hyperemia-similarly-in-males-and-females
#2
Scott J Dankel, J Grant Mouser, Matthew B Jessee, Kevin T Mattocks, Samuel L Buckner, Jeremy P Loenneke
PURPOSE: Our laboratory recently demonstrated that post-exercise blood flow restriction attenuated muscle hypertrophy only in females, which we hypothesized may be due to alterations in post-exercise blood flow. The aim of this study is to test our previous hypothesis that sex differences in blood flow would exist when employing the same protocol. METHODS: Twenty-two untrained individuals (12 females; 10 males) performed two exercise sessions, each involving one set of elbow flexion exercise to volitional failure on the right arm...
June 22, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28641993/peer-review-for-selection-of-oral-presentations-for-conferences-are-we-reliable
#3
Myriam Deveugele, Jonathan Silverman
INTRODUCTION: Although peer-review for journal submission, grant-applications and conference submissions has been called 'a counter- stone of science', and even 'the gold standard for evaluating scientific merit', publications on this topic remain scares. Research that has investigated peer-review reveals several issues and criticisms concerning bias, poor quality review, unreliability and inefficiency. The most important weakness of the peer review process is the inconsistency between reviewers leading to inadequate inter-rater reliability...
June 16, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28638239/using-transfer-learning-for-improved-mortality-prediction-in-a-data-scarce-hospital-setting
#4
Thomas Desautels, Jacob Calvert, Jana Hoffman, Qingqing Mao, Melissa Jay, Grant Fletcher, Chris Barton, Uli Chettipally, Yaniv Kerem, Ritankar Das
Algorithm-based clinical decision support (CDS) systems associate patient-derived health data with outcomes of interest, such as in-hospital mortality. However, the quality of such associations often depends on the availability of site-specific training data. Without sufficient quantities of data, the underlying statistical apparatus cannot differentiate useful patterns from noise and, as a result, may underperform. This initial training data burden limits the widespread, out-of-the-box, use of machine learning-based risk scoring systems...
2017: Biomedical Informatics Insights
https://www.readbyqxmd.com/read/28637296/omixcore-a-web-server-for-prediction-of-protein-interactions-with-large-rna
#5
Alexandros Armaos, Davide Cirillo, Gian Gaetano Tartaglia
Summary: Here we introduce omiXcore, a server for calculations of protein binding to large RNAs (> 500 nucleotides). Our webserver allows (i) use of both protein and RNA sequences without size restriction; (ii) pre-compiled library for exploration of human long intergenic RNAs (lincRNAs) interactions; (iii) prediction of binding sites. Results: omiXcore was trained and tested on enhanced UV Cross-Linking and ImmunoPrecipitation (eCLIP) data. The method discriminates interacting and non-interacting protein-RNA pairs and identifies RNA binding sites with Areas under the ROC curve > 0...
June 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28630576/no-effect-of-a-whey-growth-factor-extract-during-resistance-training-on-strength-body-composition-or-hypertrophic-gene-expression-in-resistance-trained-young-men
#6
Michael J Dale, Alison M Coates, Peter R C Howe, Grant R Tomkinson, Matthew T Haren, Andrew Brown, Marissa Caldow, David Cameron-Smith, Jonathan D Buckley
Growth factors can be isolated from bovine milk to form a whey growth factor extract (WGFE). This study examined whether WGFE promoted activation of the AKT/mTOR pathway enabling increased lean tissue mass and strength in resistance trained men. Forty six men with >6 months of resistance training (RT) experience performed 12 weeks of RT. Participants consumed 20 g/day of whey protein and were randomised to receive either 1.6 g WGFE/day (WGFE; n = 22) or 1.6 g cellulose/day (control, CONT; n = 24). The primary outcome was leg press one-repetition maximum (LP1-RM) which was assessed at baseline, 6 and 12 weeks...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28620575/osteoporosis-management-in-ankylosing-spondylitis
#7
Alicia M Hinze, Grant H Louie
Low bone mineral density (BMD) is increasingly recognized as a common comorbid condition in ankylosing spondylitis (AS). As low BMD increases fracture risk, it is important to identify and treat low BMD in patients with AS who have been shown to be at increased risk for fractures above the population normal. Since low BMD occurs early in disease, we screen during the first year of diagnosis with dual energy x-ray absorptiometry (DXA). If patients are found to have osteoporosis by T-score of less than -2.5 or if their Z-score on DXA is more than two standard deviations below the mean, we initiate therapy with bisphosphonates in males and in females who are not planning any future pregnancies...
December 2016: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28611110/the-liftmor-m-lifting-intervention-for-training-muscle-and-osteoporosis-rehabilitation-for-men-trial-protocol-for-a-semirandomised-controlled-trial-of-supervised-targeted-exercise-to-reduce-risk-of-osteoporotic-fracture-in-older-men-with-low-bone-mass
#8
Amy T Harding, Benjamin K Weeks, Steven L Watson, Belinda R Beck
INTRODUCTION: The primary aim of the proposed study is to examine the efficacy of an 8-month supervised, high-intensity progressive resistance training and impact loading programme in comparison with a supervised machine-based isometric exercise training programme using the bioDensity system in older men with low bone mass. We will also determine the safety and acceptability of each exercise training mode. Intervention group responses will be compared with those of a self-selected, non-randomised control sample of sex-matched and age-matched men who will follow their usual lifestyle activities for 8 months...
June 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28610590/a-continuous-quality-improvement-intervention-to-improve-the-effectiveness-of-community-health-workers-providing-care-to-mothers-and-children-a-cluster-randomised-controlled-trial-in-south-africa
#9
Christiane Horwood, Lisa Butler, Pierre Barker, Sifiso Phakathi, Lyn Haskins, Merridy Grant, Ntokozo Mntambo, Nigel Rollins
BACKGROUND: Community health workers (CHWs) play key roles in delivering health programmes in many countries worldwide. CHW programmes can improve coverage of maternal and child health services for the most disadvantaged and remote communities, leading to substantial benefits for mothers and children. However, there is limited evidence of effective mentoring and supervision approaches for CHWs. METHODS: This is a cluster randomised controlled trial to investigate the effectiveness of a continuous quality improvement (CQI) intervention amongst CHWs providing home-based education and support to pregnant women and mothers...
June 13, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28605253/pre-cooling-with-crushed-ice-is-as-effective-as-heat-acclimation-at-improving-cycling-time-trial-performance-in-the-heat
#10
Matthew Zimmermann, Grant J Landers, Karen E Wallman, Georgina Kent
This study compared pre-cooling (ice ingestion) with heat acclimation training on cycling time trial (CTT) performance in the heat. Fifteen male cyclists/triathletes completed two 800 kJ cycle time trials in the heat, with a 12-day training program in between. Initially, all participants consumed 7 g·kg(-1) of water (22°C) in 30 min, prior to completing an 800 kJ CTT in hot, humid conditions (pre-CTT) (35°C, 50% relative humidity; RH). Participants were then split into two groups, pre-cooling (n=7): trained in thermoneutral conditions then underwent pre-cooling with ice ingestion (7 g·kg(-1),1°C) prior to the final CTT (post-CTT), heat acclimation (n=8): trained in hot conditions (35°C, 50% RH) and consumed water (7 g·kg(-1)) prior to post-CTT...
June 12, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28604322/training-and-support-to-improve-icd-coding-quality-a-controlled-before-and-after-impact-evaluation
#11
Robin Dyers, Grant Ward, Shane Du Plooy, Stephanus Fourie, Juliet Evans, Hassan Mahomed
BACKGROUND: The proposed National Health Insurance policy for South Africa (SA) requires hospitals to maintain high-quality International Statistical Classification of Diseases (ICD) codes for patient records. While considerable strides had been made to improve ICD coding coverage by digitising the discharge process in the Western Cape Province, further intervention was required to improve data quality. The aim of this controlled before-and-after study was to evaluate the impact of a clinician training and support initiative to improve ICD coding quality...
May 24, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28603156/conflicts-of-interest-and-distribution-of-resources-to-community-partners-an-organizational-ethics-dilemma
#12
Allison M Cole, Laura-Mae Baldwin, Gina A Keppel, Ellen Kuwana, Brenda L Mollis, Benjamin S Wilfond
BACKGROUND: Conflicts of interest can arise when faculty and staff administer programs that distribute research funds, training opportunities, and other resources across academic and community partners. We describe the ethical concerns encountered by a Clinical Translational Science Award (CTSA) program in administering its community-focused pilot grant program and how its Research Bioethics Consultation service helped to address them.Ethical Concerns: CTSA program faculty and staff identified ethical concerns in several areas, including appropriateness of including Regional Research Collaborations (RRC) faculty as principal or co-investigators on applications, determining how much help RRC faculty and staff should provide to prospective applicants, and creating a fair and effective application review process...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/28600711/what-s-in-a-name-tensions-between-formal-and-informal-communities-of-practice-among-regional-subspecialty-cancer-surgeons
#13
Simon C Kitto, Rachel E Grant, Jennifer Peller, Carol-Anne Moulton, Steven Gallinger
In 2007 the Cancer Care Ontario Hepatobiliary-Pancreatic (HPB) Community of Practice was formed during the wake of provincial regionalization of HPB services in Ontario, Canada. Despite being conceptualized within the literature as an educational intervention, communities of practice (CoP) are increasingly being adopted in healthcare as quality improvement initiatives. A qualitative case study approach using in-depth interviews and document analysis was employed to gain insight into the perceptions and attitudes of the HPB surgeons in the CoP...
June 9, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28598948/causes-for-pauses-during-simulated-pediatric-cardiac-arrest
#14
David Oren Kessler, Dawn Taylor Peterson, Alexis Bragg, Yiqun Lin, John Zhong, Jonathan Duff, Mark Adler, Linda Brown, Farhan Bhanji, Jennifer Davidson, David Grant, Adam Cheng
OBJECTIVES: Pauses in cardiopulmonary resuscitation negatively impact clinical outcomes; however, little is known about the contributing factors. The objective of this study is to determine the frequency, duration, and causes for pauses during cardiac arrest. DESIGN: This is a secondary analysis of video data collected from a prospective multicenter trial. Twenty-six simulated pediatric cardiac arrest scenarios each lasting 12 minutes in duration were analyzed by two independent reviewers to document events surrounding each pause in chest compressions...
June 8, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28596910/research-capacity-strengthening-in-south-asia-based-on-the-experience-of-south-asian-hub-for-advocacy-research-and-education-on-mental-health-share
#15
M Sharma, B Razzaque
The South Asian Hub for Advocacy, Research and Education (SHARE) was a five-year National Institute of Mental Health (NIMH)-funded program that aimed to stimulate the research base for task-shifting mental health interventions to address the mental health treatment gap in low and middle-income countries. During its 5 years (2011-2016) SHARE made notable accomplishments, including providing 20 studentships for short courses and ten fellowships to conduct mentored study, developing a new humanitarian research training course, implementing distance learning courses, creating an online repository of training materials, creation of a network of public health researchers at different career stages in South Asia, strengthening of partnerships amongst institutions of SHARE network and supporting its member's to produce peer reviewed publications...
2017: Global Mental Health
https://www.readbyqxmd.com/read/28592522/feasibility-of-physiologist-led-stress-echocardiography-for-the-assessment-of-coronary-artery-disease
#16
Jamal Nasir Khan, Timothy Griffiths, Tamseel Fatima, Leah Michael, Andreea Mihai, Zeeshan Mustafa, Kully Sandhu, Robert Butler, Simon Duckett, Grant Heatlie
BACKGROUND: Physiologist-led stress echocardiography (PLSE) services provide potential for expansion of SE services and increased productivity for cardiologists. There are no published data on the feasibility of PLSE. We sought to assess the feasibility, safety and robustness of PLSE and CLSE for coronary artery disease (CAD) assessment. METHODS: Retrospective analysis of 898 patients undergoing PLSE or CLSE for CAD assessment using exercise or dobutamine stress over 24 months...
June 7, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28582988/trust-of-community-health-workers-influences-the-acceptance-of-community-based-maternal-and-child-health-services
#17
Merridy Grant, Aurene Wilford, Lyn Haskins, Sifiso Phakathi, Ntokozo Mntambo, Christiane M Horwood
BACKGROUND: Community health workers (CHWs) are a component of the health system in many countries, providing effective community-based services to mothers and infants. However, implementation of CHW programmes at scale has been challenging in many settings. AIM: To explore the acceptability of CHWs conducting household visits to mothers and infants during pregnancy and after delivery, from the perspective of community members, professional nurses and CHWs themselves...
May 29, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28579627/carriage-of-sub-microscopic-sexual-and-asexual-plasmodium-falciparum-stages-in-the-dry-season-at-navrongo-ghana
#18
Geoffrey R Atelu, Nancy O Duah, Michael D Wilson
BACKGROUND: We investigated the prevalence of sub-microscopic Plasmodium falciparum infections and gametocyte carriage in asymptomatic individuals in Navrongo in northern Ghana, an area of seasonal malaria transmission. DESIGN: A cross sectional study of 209 randomly selected participants of all age-groups was conducted in February and March, 2015. METHODS: Capillary blood samples collected from these individuals were used for the detection of both asexual and gametocyte stage parasites by microscopy, reverse transcriptase polymerase chain reaction (RT-PCR) and conventional nested PCR methods...
December 2016: Ghana Medical Journal
https://www.readbyqxmd.com/read/28576661/knowledge-and-practice-related-to-gestational-diabetes-among-primary-health-care-providers-in-morocco-potential-for-a-defragmentation-of-care
#19
Bettina Utz, Bouchra Assarag, Amina Essolbi, Amina Barkat, Alexandre Delamou, Vincent De Brouwere
INTRODUCTION: The objective of this study was to assess knowledge and practices of general practitioners, nurses and midwives working at primary health care facilities in Morocco regarding screening and management of gestational diabetes (GDM). METHODS: Structured interviews with 100 doctors, midwives and nurses at 44 randomly selected public health care centers were conducted in Marrakech and Al Haouz. All data were descriptively analyzed. Ethical approval for the study was granted by the institutional review boards in Belgium and Morocco...
May 30, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28575355/standardization-of-clinical-assessment-and-sample-collection-across-all-perch-study-sites
#20
Jane Crawley, Christine Prosperi, Henry C Baggett, W Abdullah Brooks, Maria Deloria Knoll, Laura L Hammitt, Stephen R C Howie, Karen L Kotloff, Orin S Levine, Shabir A Madhi, David R Murdoch, Katherine L O'Brien, Donald M Thea, Juliet O Awori, Charatdao Bunthi, Andrea N DeLuca, Amanda J Driscoll, Bernard E Ebruke, Doli Goswami, Melissa M Hidgon, Ruth A Karron, Sidi Kazungu, Nana Kourouma, Grant Mackenzie, David P Moore, Azwifari Mudau, Magdalene Mwale, Kamrun Nahar, Daniel E Park, Barameht Piralam, Phil Seidenberg, Mamadou Sylla, Daniel R Feikin, J Anthony G Scott
Background.: Variable adherence to standardized case definitions, clinical procedures, specimen collection techniques, and laboratory methods has complicated the interpretation of previous multicenter pneumonia etiology studies. To circumvent these problems, a program of clinical standardization was embedded in the Pneumonia Etiology Research for Child Health (PERCH) study. Methods.: Between March 2011 and August 2013, standardized training on the PERCH case definition, clinical procedures, and collection of laboratory specimens was delivered to 331 clinical staff at 9 study sites in 7 countries (The Gambia, Kenya, Mali, South Africa, Zambia, Thailand, and Bangladesh), through 32 on-site courses and a training website...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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