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https://www.readbyqxmd.com/read/29913280/emricasan-improves-liver-function-in-patients-with-cirrhosis-and-high-model-for-end-stage-liver-disease-scores-compared-with-placebo
#1
Catherine T Frenette, Giuseppe Morelli, Mitchell L Shiffman, R Todd Frederick, Raymond A Rubin, Michael B Fallon, Jason T Cheng, Matt Cave, Saira A Khaderi, Omar Massoud, Nikolaos Pyrsopoulos, James S Park, James M Robinson, Mason Yamashita, Alfred P Spada, Jean L Chan, David T Hagerty
BACKGROUND & AIMS: Caspase-mediated apoptosis and inflammation contribute to progression of liver disease. Emricasan is a pan-caspase inhibitor that reduced serum markers of apoptosis and liver inflammation in patients with hepatitis C and non-alcoholic steatohepatitis (NASH). METHODS: We performed a multicenter study of 86 patients with cirrhosis (Child-Pugh class A or B; mean score, 6.9; 38% with alcohol-associated cirrhosis, 29% with HCV-associated cirrhosis, and 23% with NASH) and model for end-stage liver disease (MELD) scores of 11-18 (mean, 12...
June 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29913113/the-frequency-of-false-allegations-of-child-sexual-abuse-a-critical-review
#2
William O'Donohue, Caroline Cummings, Brendan Willis
The rate of false allegations has been a topic of research spanning back to as early as the 1970s. Studies have often relied on data gathered by Child Protective Services workers and court administrators. Some researchers have also used hypothetical scenarios to estimate rates. However, given the plethora of sampling methods, there is a large variation in estimated rates of false allegations of sexual abuse depending on the data source and context of the allegation. Additionally, methodological problems such as unclear or invalid criteria used to judge truth or falsity of an allegation, unrepresentative samples, and ignoring important contextual variables such as the stage at which an allegation is made, currently all render the determination of actual rates of false child sexual abuse allegations to be unknown...
June 18, 2018: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/29913088/development-of-therapist-adherence-in-relation-to-treatment-outcomes-of-adolescents-with-behavioral-problems
#3
Aurelie M C Lange, Rachel E A van der Rijken, Marc J M H Delsing, Jan J V Busschbach, Ron H J Scholte
Therapist adherence to the treatment manual is assumed to be crucial for adequate implementation and subsequent achievement of the intended, positive treatment outcomes. Although adherence has been mostly studied as a static factor, recent studies suggest that adherence might be dynamic and changes over time. We investigated how parent-perceived adherence to the multisystemic therapy (MST) model develops during treatment and how this development is related to treatment outcomes up to 18 months posttreatment, controlling for the effect of alliance...
June 18, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29912601/preliminary-efficacy-of-a-friendly-constraint-induced-therapy-friendly-cit-program-on-motor-and-psychosocial-outcomes-in-children-with-cerebral-palsy
#4
Yu-Lun Chen, Hao-Ling Chen, Jeng-Yi Shieh, Tien-Ni Wang
AIMS: Constraint-induced therapy (CIT) is effective, but concerns have been repeatedly raised regarding the generalizability, feasibility, and potentially intrusive nature of restraining a child's unimpaired upper limb. We examined the feasibility and efficacy of friendly-CIT, which uses home-based model, a caregiver-determined schedule, and gentle restraint, in children with cerebral palsy. METHODS: In a one-group pre-post intervention trial, 15 children (median of age = 8 years, 4 months) participated in 8 weeks of friendly-CIT (36 hours)...
June 18, 2018: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/29911521/integrated-perinatal-mental-health-care-a-national-model-of-perinatal-primary-care-in-vulnerable-populations
#5
Kimberly C Lomonaco-Haycraft, Jennifer Hyer, Britney Tibbits, Jennifer Grote, Kelly Stainback-Tracy, Claire Ulrickson, Alison Lieberman, Lies van Bekkum, M Camille Hoffman
IntroductionPerinatal mood and anxiety disorders (PMADs) are the most common complication of pregnancy and have been found to have long-term implications for both mother and child. In vulnerable patient populations such as those served at Denver Health, a federally qualified health center the prevalence of PMADs is nearly double the nationally reported rate of 15-20%. Nearly 17% of women will be diagnosed with major depression at some point in their lives and those numbers are twice as high in women who live in poverty...
June 18, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29910991/unfamiliar-face-matching-with-photographs-of-infants-and-children
#6
Robin S S Kramer, Jerrica Mulgrew, Michael G Reynolds
Background: Infants and children travel using passports that are typically valid for five years (e.g. Canada, United Kingdom, United States and Australia). These individuals may also need to be identified using images taken from videos and other sources in forensic situations including child exploitation cases. However, few researchers have examined how useful these images are as a means of identification. Methods: We investigated the effectiveness of photo identification for infants and children using a face matching task, where participants were presented with two images simultaneously and asked whether the images depicted the same child or two different children...
2018: PeerJ
https://www.readbyqxmd.com/read/29910752/gender-differences-in-how-family-income-and-parental-education-relate-to-reading-achievement-in-china-the-mediating-role-of-parental-expectation-and-parental-involvement
#7
Xiaolin Guo, Bo Lv, Huan Zhou, Chunhui Liu, Juan Liu, Kexin Jiang, Liang Luo
The impact of social economic status (SES) on children's academic outcomes has been well documented. However, the mechanisms underlying this relationship remain poorly understood. Furthermore, the process by which SES relates to academic achievement needs to be studied separately for boys and girls. Using a sample of 598 Chinese children (299 boys, 299 girls) in grades 4 to 6 and their parents, this study examined the process of how family SES, specifically family income and parental education, indirectly relates to children's reading achievement through parental expectation and parental involvement and whether this process differs between boys and girls...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29910617/acetaminophen-antibiotics-ear-infection-breastfeeding-vitamin-d-drops-and-autism-an-epidemiological-study
#8
Seth Scott Bittker, Kathleen Roberta Bell
Background: While many studies have examined environmental risk factors for autism spectrum disorder (ASD), much of the research focus has been on prenatal or perinatal factors. Yet, the postnatal environment may affect the risk of ASD as well. Objective: To determine whether a set of five postnatal variables are associated with ASD. These variables are: acetaminophen exposure, antibiotic exposure, incidence of ear infection, decreased duration of breastfeeding, and decreased consumption of oral vitamin D drops...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29910308/links-between-adolescent-athletes-prosocial-behavior-and-relationship-with-parents-a-mixed-methods-study
#9
Aušra Lisinskienė, Marc Lochbaum
Adolescent relationships with parents are of the highest importance. The relationships likely reflect the nature of internal working models in youth sport that may well function as a psychological template during the construction of youth prosocial behavior. However, researchers' focus to date has concerned specific aspects of parental practices in child-based sporting activities. There is a lack of research covering parent-athlete interpersonal relationships concerned with how the relationships affect adolescent prosocial behavior...
January 17, 2018: Sports (Basel)
https://www.readbyqxmd.com/read/29909940/management-of-healthy-newborns-in-the-delivery-room-and-maternal-satisfaction
#10
A Tasseau, E Walter-Nicolet, F Autret
INTRODUCTION: The first exchanges between a newborn baby and its mother are essential. Any separation can have negative effects on the establishment of the first connections as well as breastfeeding. OBJECTIVE: To establish the current state of management of healthy newborn babies in the delivery room and assess the reasons for possible separation and the feelings of mothers facing this separation. MATERIALS AND METHODS: Observational descriptive single-center study, made up of two parts: 1/a questionnaire given to the mothers, postpartum; 2/the collection of data concerning the transfer of healthy newborn babies to the nursery...
June 14, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29909713/how-does-exposure-to-violence-affect-school-delay-and-academic-motivation-for-adolescents-living-in-socioeconomically-disadvantaged-communities-in-south-africa
#11
Rocio Herrero Romero, James Hall, Lucie Cluver, Franziska Meinck, Eleanor Hinde
To date, little is known about the effects of violence on the educational outcomes of adolescents in disadvantaged communities in South Africa. In response, self-report data were collected from a socioeconomically disadvantaged sample of 503 adolescents aged 10 to 18 participating in a child abuse prevention trial in the Eastern Cape. Adolescents were purposively selected in the trial. This study applies Latent Profile Analysis (LPA) to examine relationships between past-month exposure to violence, school delay, and academic motivation...
June 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29909138/narcolepsy-and-hypothalamic-region-tumors-presentation-and-evolution
#12
Alexander G Weil, Katherine Muir, Juliette Hukin, Alex Desautels, Véronique Martel, Sébastien Perreault
OBJECTIVE: Because most cases of brain tumor-associated narcolepsy have been published in the form of case reports or small series, the clinical presentation and evolution have not been well described. We sought to better define the epidemiology, etiology, and outcome of brain tumor-related narcolepsy. METHODS: We conducted an extensive review of the literature to identify cases of narcolepsy associated with brain tumors. Only cases of brain tumors involving the hypothalamic region including the suprasellar, sellar, and thalamus were included in this study...
February 14, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29908977/promoting-greater-diversity-and-inclusion-in-radiology-research-a-survey-of-the-american-association-for-women-radiologists
#13
Andrew B Rosenkrantz, Margaret M Szabunio, Katarzyna J Macura
OBJECTIVES: To assess perceived challenges to radiology research and publication by female radiologists, as well as possible strategies for overcoming these challenges. METHODS: An electronic survey was conducted of female nontrainee members of the American Association for Women Radiologists in September and October, 2017. Respondents were recruited by e-mail. Responses were assessed descriptively. RESULTS: The response rate was 31.8% (89/280)...
June 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29908971/why-are-maternally-separated-females-inflexible-brain-activity-pattern-of-cox-and-c-fos
#14
María Banqueri, Marta Méndez, Jorge L Arias
Subjects' early life events will affect them later in life. When these events are stressful, such as child abuse in humans or repeated maternal separation in rodents, subjects can show some behavioral and brain alterations. This study used young adult female Wistar rats that were maternally raised (AFR), maternally separated from post-natal day (PND) 1 to PND10 (MS10), or maternally separated from PND1 to PND21 (MS21), in order to assess the effects of maternal separation (MS) on spatial learning and memory, as well as cognitive flexibility, using the Morris Water Maze (MWM)...
June 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29908773/maternal-diabetes-mellitus-and-timing-of-pubertal-development-in-daughters-and-sons-a-nationwide-cohort-study
#15
Lea L B Lauridsen, Linn H Arendt, Andreas Ernst, Nis Brix, Erik T Parner, Jørn Olsen, Cecilia H Ramlau-Hansen
OBJECTIVE: To study the association between maternal diabetes and timing of pubertal development in daughters and sons. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 15,822 mother-child pairs included in the Danish National Birth Cohort and the Puberty Cohort with prospectively collected, register-based and self-reported information on maternal diabetes and self-reported information on pubertal development...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29908772/first-in-vitro-fertilization-baby-this-is-how-it-happened
#16
REVIEW
Simon Fishel
On July 25, 1978, the first human was born following extracorporeal fertilization, an event that opened up a new medical science: expanding our knowledge of and developing novel treatments for infertility, radically changing the opportunities for families with inherited monogenic disorders, generating the new discipline of clinical embryology, and paving the way for studies into stem cell biology. In vitro fertilization (IVF), as it became known in its simplest form, went even further: it engaged the myriad of minds in human society...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29908436/adverse-experiences-in-infancy-and-toddlerhood-relations-to-adaptive-behavior-and-academic-status-in-middle-childhood
#17
Lorraine M McKelvey, Nicola Conners Edge, Glenn R Mesman, Leanne Whiteside-Mansell, Robert H Bradley
Findings from the Adverse Childhood Experiences (ACE) study articulated the negative effects of childhood trauma on long-term well-being. The purpose of the current study is to examine the associations between ACEs experienced in infancy and toddlerhood and adaptive behavior and academic status in middle childhood. We used data collected from a sample of low-income families during the impacts study of Early Head Start (EHS). Data were collected by trained interviewers demonstrating at least 85% reliability with protocols...
June 13, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29907598/clinical-response-of-the-novel-activating-alk-i1171t-mutation-in-neuroblastoma-to-the-alk-inhibitor-ceritinib
#18
Jikui Guan, Susanne Fransson, Joachim Tetteh T Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Petter Svenberg, Kristina Ruuth, Sandra Wessman, Alia Shamikh, Hans Jacobsson, Lena Gordon, Jakob Stenman, Erik Larsson, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H Palmer, Bengt Hallberg
Tumors with Anaplastic Lymphoma Kinase (ALK) fusion rearrangements, including non-small cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. While mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been disappointing. Embryonal tumors in patients with DNA repair defects such as Fanconi anemia (FA) often have a poor prognosis, due to lack of therapeutic options...
June 15, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29907177/-sharing-to-improve-our-way-of-working
#19
REVIEW
Julien Billères, Frédérique Marrodal, Ivan Gicquel
Inter-day hospital supervisions in child psychiatry, through clinical and case studies, give caregivers a chance to review and reflect on their practices as well as training and tools. Experienced psychiatry experts share their knowledge. Through the exchanges, professionals analyse and develop practices. Caregivers from Toulouse describe the benefits observed through these practices both on a collective and individual level.
June 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29905942/quality-of-life-in-patients-with-proton-treated-pediatric-medulloblastoma-results-of-a-prospective-assessment-with-5-year-follow-up
#20
Sophia C Kamran, Saveli I Goldberg, Karen A Kuhlthau, Miranda P Lawell, Elizabeth A Weyman, Sara L Gallotto, Clayton B Hess, Mary S Huang, Alison M Friedmann, Annah N Abrams, Shannon M MacDonald, Margaret B Pulsifer, Nancy J Tarbell, David H Ebb, Torunn I Yock
BACKGROUND: To the authors' knowledge, health-related quality of life (HRQOL) outcomes are not well described in patients with medulloblastoma. The use of proton radiotherapy (RT) may translate into an improved HRQOL. In the current study, the authors report long-term HRQOL in patients with proton-treated pediatric medulloblastoma. METHODS: The current study was a prospective cohort HRQOL study of patients with medulloblastoma who were treated with proton RT and enrolled between August 5, 2002, and October 8, 2015...
June 15, 2018: Cancer
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