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https://www.readbyqxmd.com/read/27798768/network-based-expression-analysis-reveals-key-genes-related-to-glucocorticoid-resistance-in-infant-acute-lymphoblastic-leukemia
#1
Zaynab Mousavian, Abbas Nowzari-Dalini, Ronald W Stam, Yasir Rahmatallah, Ali Masoudi-Nejad
PURPOSE: Despite vast improvements that have been made in the treatment of children with acute lymphoblastic leukemia (ALL), the majority of infant ALL patients (~80 %, < 1 year of age) that carry a chromosomal translocation involving the mixed lineage leukemia (MLL) gene shows a poor response to chemotherapeutic drugs, especially glucocorticoids (GCs), which are essential components of all current treatment regimens. Although addressed in several studies, the mechanism(s) underlying this phenomenon have remained largely unknown...
October 31, 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27778118/a-panel-of-autoantibodies-as-potential-early-diagnostic-serum-biomarkers-in-patients-with-breast-cancer
#2
Ying Liu, Ying Liao, Linlin Xiang, Kuo Jiang, Siyao Li, Mingmei Huangfu, Shilong Sun
BACKGROUND: Specific circulating autoantibodies are produced by host immune systems to respond to antigens that arise during tumorigenesis. To achieve auxiliary diagnosis, the present study was designed to test whether circulating autoantibodies against tumor-associated antigens (TAAs) were altered in early breast cancer. METHODS: A total of 102 breast cancer patients and 146 age-matched healthy volunteers were recruited to participate in this study. Autoantibody expression was tested using in-house developed enzyme-linked immunosorbent assay (ELISA) with linear peptide envelope antigens derived from TAAs...
October 24, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27399455/176%C3%A2-andexanet-alfa-an-investigational-universal-antidote-for-reversal-of-anticoagulation-of-factor-xa-inhibitors-in-healthy-human-volunteers
#3
Florie Mar, Mark Crowther, Alex Gold, Genmin Lu, Janet Leeds, Brian Wiens, Vandana Mathur, Janice Castillo, Pamela Conley, Stuart Connolly, John Curnutte
INTRODUCTION: Direct FXa inhibitors have demonstrated convincing anticoagulant efficacy. However, risk of major bleeding is a concern and no specific antidotes are available for reversal. Andexanet alfa (AnXa), a recombinant modified FXa, is an investigational specific antidote for FXa inhibitors. We report data from the ANNEXA"! Phase 3 registration studies in older healthy subjects anticoagulated with apixaban (apix) or rivaroxaban (riva). METHODS: ANNEXA A&R were 2 phase 3, randomized, double-blind, placebo-controlled studies of AnXa in healthy subjects age 50 to 75 administered either apixaban or rivaroxaban...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27274723/annexin-a2-coordinates-stat3-to-regulate-the-invasion-and-migration-of-colorectal-cancer-cells-in-vitro
#4
Dianhui Xiu, Lin Liu, Fengli Qiao, Haishan Yang, Lu Cui, Guifeng Liu
The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27188606/-expression-of-annexin-a7-and-its-clinical-significance-in-gastric-carcinoma
#5
H F Yuan, Y Li, B B Tan, Q Zhao, L Q Fan, W H Ye
OBJECTIVE: To investigate the expression of annexin A7 (ANXA7) in the differentiation and lymphatic metastasis of gastric cancer (GC), and to investigate the relationship between ANXA7 and biological characteristics of GC. METHODS: The clinicopathological data of 124 patients with gastric cancer who underwent surgical treatment in our hospital were retrospectively reviewed and analyzed. Immunohistochemical staining and Western blot were performed to analyze the expression of ANXA 7 in primary GC tissues...
May 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27145782/resolvin-d1-alleviates-the-lung-ischemia-reperfusion-injury-via-complement-immunoglobulin-tlr4-and-inflammatory-factors-in-rats
#6
Qifeng Zhao, Ji Wu, Zhiyong Lin, Qingwang Hua, Weixi Zhang, Leping Ye, Guowei Wu, Jie Du, Jie Xia, Maoping Chu, Xingti Hu
Lung ischemia-reperfusion injury (LIRI) is still an unsolved medical issue, which negatively affects the prognosis of many lung diseases. The aim of this study is to determine the effects of RvD1 on LIRI and the potential mechanisms involved. The results revealed that the levels of complement, immunoglobulin, cytokines, sICAM-1, MPO, MDA, CINC-1, MCP-1, ANXA-1, TLR4, NF-κBp65, apoptosis index, and pulmonary permeability index were increased, whereas the levels of SOD, GSH-PX activity, and oxygenation index were decreased in rats with LIRI...
August 2016: Inflammation
https://www.readbyqxmd.com/read/26686866/andexanet-alfa-for-the-reversal-of-factor-xa-inhibitor-related-anticoagulation
#7
REVIEW
Kamrouz Ghadimi, Keith E Dombrowski, Jerrold H Levy, Ian J Welsby
Andexanet alfa is a specific reversal agent for Factor Xa inhibitors. The molecule is a recombinant protein analog of factor Xa that binds to Factor Xa inhibitors and antithrombin:LMWH complex but does not trigger prothrombotic activity. In ex vivo, animal, and volunteer human studies, andexanet alfa (AnXa) was able to dose-dependently reverse Factor Xa inhibition and restore thrombin generation for the duration of drug administration. Further trials are underway to examine its safety and efficacy in the population of patients experiencing FXa inhibitor-related bleeding...
2016: Expert Review of Hematology
https://www.readbyqxmd.com/read/26223656/vibrio-vulnificus-vvpe-stimulates-il-1%C3%AE-production-by-the-hypomethylation-of-the-il-1%C3%AE-promoter-and-nf-%C3%AE%C2%BAb-activation-via-lipid-raft-dependent-anxa2-recruitment-and-reactive-oxygen-species-signaling-in-intestinal-epithelial-cells
#8
Sei-Jung Lee, Young Hyun Jung, Eun Ju Song, Kyung Ku Jang, Sang Ho Choi, Ho Jae Han
An inflammatory response is a hallmark of necrosis evoked by bacterial pathogens. Vibrio vulnificus, VvpE, is an elastase that is responsible for tissue necrosis and inflammation; however, the molecular mechanism by which it regulates host cell death has not been characterized. In the present study, we investigate the cellular mechanism of VvpE with regard to host cell death and the inflammatory response of human intestinal epithelial (INT-407) cells. The recombinant protein (r)VvpE (50 pg/ml) caused cytotoxicity mainly via necrosis coupled with IL-1β production...
September 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26076081/if7-conjugated-nanoparticles-target-annexin-1-of-tumor-vasculature-against-p-gp-mediated-multidrug-resistance
#9
De-Hong Yu, Ya-Rong Liu, Xin Luan, Hai-Jun Liu, Yun-Ge Gao, Hao Wu, Chao Fang, Hong-Zhuan Chen
Multidrug resistance is the main cause of clinical chemotherapeutic failure. Antiangiogenic cancer therapy with nanomedicine that allows the targeted delivery of antiangiogenic agents to tumor endothelial cells may contribute to innovative strategies for treating multidrug-resistant cancers. In this study, we developed a new nanodrug delivery system (nano-DDS), with improved antiangiogenic efficacy against multidrug resistant human breast cancer MCF-7/ADR cells. Here, the IF7 ligand was a peptide designed to bind the annexin 1 (Anxa 1), a highly specific marker of the tumor vasculature surface, with high affinity and specificity...
August 19, 2015: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/25400735/expression-of-annexin-a7-and-its-clinical-significance-in-differentiation-and-metastasis-of-gastric-carcinoma
#10
Hu-Fang Yuan, Yong Li, Qun Zhao, Li-Qiao Fan, Bi-Bo Tan, Wei-Hua Ye
OBJECTIVE: To investigate the expression and clinical significance of annexin A7 in the differentiation and lymphatic metastasis of gastric cancer (GC). METHODS: The clinical and pathological data were recorded for analysis. Immunohistochemical staining and Western blot were performed to analyze the expression of ANXA 7 in primary GC tissues. Logistic regression analyses were conducted to evaluate the associations between annexin A7 expression levels and differentiations of GC...
2014: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/25362540/characterization-of-pro-invasive-mechanisms-and-n-terminal-cleavage-of-anxa1-in-melanoma
#11
Z Boudhraa, C Merle, D Mazzocut, J M Chezal, C Chambon, E Miot-Noirault, M Theisen, B Bouchon, F Degoul
Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and STAT3 pathways. To decipher endogenous annexin A1 action mode, we showed that annexin A1 is externalized in A375 cells and cleaved by a membrane-associated serine protease, allowing the release of a pro-invasive annexin A1 peptide in the extra cellular environment...
December 2014: Archives of Dermatological Research
https://www.readbyqxmd.com/read/24348815/inhibition-of-annexin-a2-gene-transcription-is-a-promising-molecular-target-for-hepatoma-cell-proliferation-and-metastasis
#12
Zhizhen Dong, Min Yao, Haijian Zhang, Li Wang, Hua Huang, Meijuan Yan, Wei Wu, Dengfu Yao
Hepatocyte Annexin A2 (ANXA2) expression is associated with the progression and metastasis of hepatocellular carcinoma (HCC). Circulating ANXA2 levels in HCC patients are significantly higher compared with that of patients with benign liver disease. ANXA2 levels have been found to correlate with hepatitis B virus infection, extrahepatic metastasis and portal vein thrombus. By contrast, ANXA2 levels do not correlate with tumour size and AFP levels. However, the underlying mechanisms of ANXA2 remain obscure. The results of the current study identified that abnormalities in hepatic ANXA2 expression were localised to the cell membrane and cytoplasm of HCC tissues and mainly in the cytoplasm of para-cancerous tissues...
January 2014: Oncology Letters
https://www.readbyqxmd.com/read/23977414/annexin-a6-is-down-regulated-through-promoter-methylation-in-gastric-cancer
#13
Xian Wang, Shengjie Zhang, Jianbin Zhang, Emily Lam, Xin Liu, Jie Sun, Lifeng Feng, Haiqi Lu, Jun Yu, Hongchuan Jin
BACKGROUND: The aberrant activation of oncogenic signaling such as Ras/MAPK signaling is a frequent event in human cancers. In addition to genetic changes, epigenetic silencing of inhibitors in Ras/MAPK signaling contributes to the activation of Ras/MAPK signaling. Recently, ANXA6 has been shown to interact with Ras-GAP1 and inhibit Ras activation in human breast cancer. However, whether and how it is involved in human cancers remain unknown. METHODS: Real-time PCR was used to determine ANXA6 expression in gastric cancer cells and primary gastric carcinomas...
2013: American Journal of Translational Research
https://www.readbyqxmd.com/read/23750556/up-regulation-of-endothelial-nitric-oxide-synthase-enos-silent-mating-type-information-regulation-2-homologue-1-sirt1-and-autophagy-related-genes-by-repeated-treatments-with-resveratrol-in-human-umbilical-vein-endothelial-cells
#14
Yoshie Takizawa, Yukiko Kosuge, Hiroyo Awaji, Emi Tamura, Ayako Takai, Takaaki Yanai, Reiko Yamamoto, Koichi Kokame, Toshiyuki Miyata, Rieko Nakata, Hiroyasu Inoue
Resveratrol, a polyphenolic phytoalexin found in red wine and various plants, has been reported to up-regulate the expression of endothelial NO synthase (eNOS) in human umbilical vein endothelial cells (HUVEC). However, this effect was neither long term in nature nor physiologically relevant at the concentration of resveratrol studied. In the present study, we investigated the effects of repeated treatments with a lower concentration of resveratrol on the expression of genes in HUVEC. The expression levels of eNOS and silent mating type information regulation 2 homologue 1 (SIRT1) were up-regulated in HUVEC by repeated treatments with 1 μm-resveratrol for 6 d, but not with fenofibrate...
December 2013: British Journal of Nutrition
https://www.readbyqxmd.com/read/22791338/annexin-a1-modulates-macula-densa-function-by-inhibiting-cyclooxygenase-2
#15
S Seidel, H Neymeyer, T Kahl, T Röschel, K Mutig, R Flower, J Schnermann, S Bachmann, A Paliege
Annexin A1 (ANXA1) exerts anti-inflammatory effects through multiple mechanisms including inhibition of prostaglandin synthesis. Once secreted, ANXA1 can bind to G protein-coupled formyl peptide receptors (Fpr) and activate diverse cellular signaling pathways. ANXA1 is known to be expressed in cells of the juxtaglomerular apparatus, but its relation to the expression of cyclooxygenase 2 (COX-2) in thick ascending limb and macula densa cells has not been elucidated. We hypothesized that ANXA1 regulates the biosynthesis of COX-2...
September 15, 2012: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/22497081/-animal-in-vivo-model-of-arrhythmia-for-genes-target-identification-for-5-amino-exo-3-azatricyclo-5-2-1-0-2-6-decan-4-one
#16
Iu V Vakhitova, E I Antipina, R S Yamidanov, R Iu Khisamutdinova, F S Zarudiĭ, N Zh Baschenko, V A Dokichev, Iu V Tomilov, O M Nefedov
The goal of the current work is to study the molecular mechanisms underlay the action of 5- amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one (P-11) with combined antiarrhythmic, nootropic, anti-inflammatory and anaesthetic activities. The aconitine-induced experimental rat model of cardiac arrhythmia has been used in our study. Aconitine was administered once intravenously in a dose 50 microg/kg whereas experimental animal group received P-11 in a dose 0.3 mg/kg (the compound was injected intravenously 2 min before acute aconitine treatment)...
November 2011: Bioorganicheskaia Khimiia
https://www.readbyqxmd.com/read/22126795/proteomics-analyses-of-human-optic-nerve-head-astrocytes-following-biomechanical-strain
#17
Ronan S Rogers, Moyez Dharsee, Suzanne Ackloo, Jeremy M Sivak, John G Flanagan
We investigate the role of glial cell activation in the human optic nerve caused by raised intraocular pressure, and their potential role in the development of glaucomatous optic neuropathy. To do this we present a proteomics study of the response of cultured, optic nerve head astrocytes to biomechanical strain, the magnitude and mode of strain based on previously published quantitative models. In this case, astrocytes were subjected to 3 and 12% stretches for either 2 h or 24 h. Proteomic methods included nano-liquid chromatography, tandem mass spectrometry, and iTRAQ labeling...
February 2012: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/20700061/detection-of-annexin-a-autoantibodies-in-sera-from-colorectal-cancer-patients
#18
Jinn-Shiun Chen, Yeh-Pin Chou, Kuei-Tien Chen, Ray-Ping Hung, Jau-Song Yu, Yu-Sun Chang, Err-Cheng Chan
BACKGROUND: Annexins (ANXAs) belong to a superfamily of closely related calcium and membrane-binding proteins and are overexpressed in some carcinomas. The overexpression of ANXAs presumably induces an autoantibody response, but this has not been demonstrated for sera from colorectal cancer (CRC) patients. STUDY: We examined serum samples from 220 CRC patients and 216 healthy volunteers to evaluate the ANXA autoantibody response in patients by using an enzyme-linked immunosorbent assay with recombinant ANXA A4 as the antigen...
February 2011: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/19345290/polymorphisms-in-the-annexin-gene-family-and-the-risk-of-osteonecrosis-of-the-femoral-head-in-the-korean-population
#19
Tae-Ho Kim, Jung Min Hong, Eun-Soon Shin, Hyun-Ju Kim, Yoon Shin Cho, Jong-Young Lee, Sang-Han Lee, Eui Kyun Park, Shin-Yoon Kim
OBJECTIVE: The pathogenesis of osteonecrosis of the femoral head (ONFH) probably reflects multiple etiologies. Recent studies have explored associations between genetic mutations and/or polymorphisms and ONFH. Annexins (ANXs) have been implicated in many physiological functions, including blood coagulation, inflammation, apoptosis, as well as Ca(2+) homeostasis in bone cells, all of which may be associated with ONFH. The aim of this study was to evaluate the possible association of AnnexinA (ANXA) family gene polymorphisms with ONFH...
July 2009: Bone
https://www.readbyqxmd.com/read/19000723/human-immunodeficiency-virus-type-1-chronic-infection-is-associated-with-different-gene-expression-in-mt-4-h9-and-u937-cell-lines
#20
Isabel Olivares, Alicia Ballester, Luis Lombardia, Orlando Dominguez, Cecilio López-Galíndez
To investigate cellular factors involved in HIV-1 chronic infection, three cell lines chronically infected with the same HIV-1 viral isolate (s61) were studied by cDNA microarray analysis. Two T cell lines, H61 and M61, showed the characteristics of a persistent infection whereas U61 cell line displayed a latent infection pattern. Analysis of genes with altered expression in the three cell lines revealed evidence of apoptosis control by up-regulation of anti-apoptotic genes and down-regulation of pro-apoptotic genes...
January 2009: Virus Research
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