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https://www.readbyqxmd.com/read/28686778/a-randomized-controlled-study-of-a-novel-botanical-acne-spot-treatment
#1
Deganit Barak-Shinar, Zoe Diana Draelos
<p>OBJECTIVE: The study evaluated the tolerability and efficacy of a new presented treatment for acne. The product is an OTC topical gel consisting of 2% SA, which is also enriched in botanicals that have been shown to have anti-inflammatory properties.</p> <p>DESIGN: The study was designed as a single-site, randomized, investigator-blinded, split-face 10-day study.</p> <p>SETTING: Subjects enrolled with a minimum of 2 inflammatory papular acne lesions and 2 non-inflammatory open or closed comedones on both sides of the face in symmetrical locations, to the greatest degree possible...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686774/prospective-study-of-pathogenesis-of-atrophic-acne-scars-and-role-of-macular-erythema
#2
Jerry Tan, Valérie Bourdès, Robert Bissonnette, Laurent Petit B Eng, Philippe Reynier, Amir Khammari, Brigitte Dreno
<p>BACKGROUND: There are few studies on the natural history of acne lesions including the antecedents of atrophic scars.</p> <p>STUDY DESIGN: Prospective study of relationship between primary (papules, pustules, comedones) and secondary lesions (atrophic scars, macular erythema, and hyperpigmentation) over 6 months. Subjects (n=32) had moderate facial acne including 10 or more atrophic acne scars and were their own control via randomized split-face design. Lesions were mapped 2x/week for 2 months and every 2 weeks thereafter until month 6 to track pathogenic progression...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28677199/acne
#3
Klaus Degitz, Falk Ochsendorf
Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF-1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28639579/postherpetic-comedones-in-two-chinese-han-patients
#4
Bo Wang, Jie Zheng, Hong-Wei Wang
No abstract text is available yet for this article.
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28594082/acneiform-eruptions-caused-by-vitamin-b12-a-report-of-five-cases-and-review-of-the-literature
#5
Stefano Veraldi, Susanna Benardon, Marco Diani, Mauro Barbareschi
We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. or oral vitamin B12. Clinical picture was characterized by papules and pustules located on the face. In three patients, similar lesions were also present on the neck, shoulders, chest, and upper portion of the back. Comedones and cysts were absent. In two patients, serum vitamin B12 levels were very high...
June 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28538881/efficacy-and-safety-of-superficial-chemical-peeling-in-treatment-of-active-acne-vulgaris
#6
Hassanain Al-Talib, Alyaa Al-Khateeb, Ayad Hameed, Chandrika Murugaiah
Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28369875/a-randomized-double-blind-placebo-controlled-trial-to-determine-the-efficacy-and-safety-of-lactoferrin-with-vitamin-e-and-zinc-as-an-oral-therapy-for-mild-to-moderate-acne-vulgaris
#7
Heidi Chan, Gertrude Chan, Joyce Santos, Kennie Dee, Juliene Kimberly Co
Lactoferrin is an iron-binding milk-derived protein that has shown antibacterial and anti-inflammatory effects in vitro and in vivo. The objective of this study was to determine the efficacy and safety of lactoferrin, combined with vitamin E and zinc, for mild to moderate acne vulgaris. In this randomized, double-blind, placebo-controlled trial, 168 subjects aged 13-40 years old were randomly assigned to take either a capsule formulation containing lactoferrin with vitamin E and zinc or placebo twice a day for 3 months...
June 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28358171/secondary-comedones-in-a-case-of-acne-conglobata-correlate-with-double-ended-pseudocomedones-in-hidradenitis-suppurativa
#8
(no author information available yet)
No abstract text is available yet for this article.
March 30, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28342238/a-peel-off-facial-mask-comprising-myoinositol-and-trehalose-loaded-liposomes-improves-adult-female-acne-by-reducing-local-hyperandrogenism-and-activating-autophagy
#9
Gabriella Fabbrocini, Claudia Capasso, Marianna Donnarumma, Mariateresa Cantelli, Michel Le Maître, Giuseppe Monfrecola, Enzo Emanuele
BACKGROUND: Hyperandrogenism and reduced skin autophagy have been implicated in the pathogenesis of adult female acne (AFA). Here, we tested whether a ready-to-use peel-off facial mask containing myoinositol (an androgen inhibitor) and trehalose-loaded liposomes (as activators of cutaneous autophagy) applied overnight every other day for 60 days can improve AFA. We also sought to investigate the molecular mechanisms underlying the clinical effects. OBJECTIVES: We conducted an uncontrolled, open-label clinical study in 40 cases of AFA to investigate the effect of the facial mask on lesion count, sebum production (measured with the Sebutape® technique), and Global Acne Grading System (GAGS) scale...
March 25, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28293556/generalized-comedones-acne-and-hidradenitis-suppurativa-in-a-patient-with-an-fgfr2-missense-mutation
#10
Rebecca Higgins, Andrew Pink, Robert Hunger, Nikhil Yawalkar, Alexander A Navarini
Mutations in the fibroblast growth factor-receptor gene 2 (FGFR2) gene have been implicated in numerous diseases, including nevus comedonicus (NC) and naevoid acne that have somatic missense mutations in FGFR2 in the affected tissue. A patient presented in our department with unusual, innumerable large comedones throughout his back reminiscient of NC, as well as multifocal hidradenitis suppurativa and acne. Topical and systemic treatments were unsuccessful. Whole exome sequencing of blood-derived DNA detected a germline mutation in FGFR2 that was predicted to be damaging...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28274355/topical-treatments-for-acne
#11
Marita Kosmadaki, Andreas Katsambas
Topical drugs have been used successfully to treat acne for decades. This review discusses the use, efficacy, and safety of options available via prescription. Topical antibiotics, dapsone, benzyl peroxide, azelaic acid, and topical retinoids are included. Topical antibiotics should not be used as monotherapy but rather be combined with other agents to avoid resistant Propionibacterium acnes strains. Benzoyl peroxide is effective in preventing bacteria resistance. Topical retinoids address primarily the comedonal but also the inflammatory lesions of acne...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28251894/characteristics-of-premenstrual-acne-flare-up-and-benefits-of-a-dermocosmetic-treatment-a-double-blind-randomised-trial
#12
Mélanie Saint-Jean, Amir Khammari, Sophie Seite, Dominique Moyal, Brigitte Dreno
To date, facial acne flare-ups in adult women during the luteal phase of the menstrual cycle have been poorly investigated. To clinically characterize premenstrual acne flare-up in adult women and investigate the effect of a dermocosmetic treatment. This single-centre study included 32 young adult women with declared premenstrual acne flares and was composed of two phases: (1) an observational phase (two menstrual cycles) and (2) an interventional phase (one menstrual cycle) in a controlled, randomised, double-blind, intra-individual (half-face) setting in which a dermocosmetic (containing lipohydroxyacid, nicotinamide, and piroctone-olamine) and placebo were compared...
March 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28244938/actinic-granuloma-annulare-with-scarring-and-open-comedones
#13
Cfb Gavioli, Nys Valente, M Sangueza, M M Nico
Actinic granuloma and annular elastolytic giant cell granuloma are variants of granuloma annulare affecting, respectively, sun-exposed and sun-covered skin sites on where, besides classical findings, abundant elastophagocytosis is observed. Here, we report a case of exuberant actinic granuloma annulare that, in addition to extensive scarring, showed multiple overlying open comedones. Markedly dilated follicular infundibula filled with compact masses of laminated keratinous material were observed in proximity to dermal inflammation composed of many histiocytes and multinucleated giant cells in close association with degenerated elastic fibers and abundant elastophagocytosis...
August 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28180934/measuring-acne-using-coproporphyrin-iii-protoporphyrin-ix-and-lesion-specific-inflammation-an-exploratory-study
#14
Sachin V Patwardhan, C Richter, A Vogt, U Blume-Peytavi, D Canfield, J Kottner
Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. acnes. In this exploratory study, for the first time, the possible relationships of Coproporphyrin III (CpIII) and Protoporphyrin IX (PpIX) fluorescence as well as acne lesion-specific inflammation measurements with clinical signs of acne are investigated...
April 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28133878/acne-ra-1-2-a-novel-uv-selective-face-cream-for-patients-with-acne-efficacy-and-tolerability-results-of-a-randomized-placebo-controlled-clinical-study
#15
Enza Cestone, Angela Michelotti, Valentina Zanoletti, Andrea Zanardi, Raffaella Mantegazza, Maurizia Dossena
BACKGROUND: General skincare measures such as the use of moisturisers and products containing adequate photoprotection are important components of acne patients' management to complement the pharmacological regimen. Acne RA-1,2 is a novel dermato-cosmetic product which contains selective photofilters and active ingredients against the multifactorial pathophysiology of acne. OBJECTIVES: To evaluate the tolerability of Acne RA-1,2 and its effect on the clinical signs of acne...
January 29, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28115862/efficacy-of-a-twice-daily-3-step-over-the-counter-skincare-regimen-for-the-treatment-of-acne-vulgaris
#16
Katie Rodan, Kathy Fields, Timothy J Falla
BACKGROUND: Acne vulgaris (acne) is the most common skin disorder producing physical and emotional scars that can persist for years. An estimated 83% of acne sufferers self-treat, but there is lack of studies documenting the effectiveness of over-the-counter (OTC) acne treatment products. OBJECTIVE: This study was conducted to determine the effectiveness of an OTC, 3-step, anti-acne skincare regimen in treating acne and improving the appearance of red/inflamed facial skin...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28094874/skin-microbiome-and-acne-vulgaris-staphylococcus-a-new-actor-in-acne
#17
Brigitte Dreno, Richard Martin, Dominique Moyal, Jessica B Henley, Amir Khammari, Sophie Seité
Propionibacterium acnes (P. acnes), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. This exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. Skin microbiota were collected under axenic conditions from comedones, papulo-pustular lesions and non-lesional skin areas from subjects with mild to moderate acne according to the GEA grading using swabs...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/27905128/ehlers-danlos-syndrome-related-to-fkbp14-mutations-detailed-cutaneous-phenotype
#18
A C Bursztejn, M Baumann, D Lipsker
In 2012, a new Ehlers-Danlos (ED) variant, characterized by severe progressive kyphoscoliosis, neonatal myopathy and hearing loss, with normal urinary lysylpyridinoline to hydroxylysylpyridinoline ratio and most often a recurrent homozygous mutation in the FKBP14 gene, was reported. Because one of the major affected tissues in ED syndrome is the skin, recognition of the cutaneous features of this newly recognized EDS variant is important. We describe the cutaneous phenotype of an adolescent girl harbouring the recurrent homozygous FKBP14 mutation...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27904577/comparison-the-effectiveness-of-pyruvic-acid-50-and-salicylic-acid-30-in-the-treatment-of-acne
#19
Fariba Jaffary, Gita Faghihi, Sara Saraeian, Sayed Mohsen Hosseini
BACKGROUND: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles and one of the most common skin diseases. The peeling method has been recently found to be effective for acne treatment. This study aimed to compare the efficacy of pyruvic acid 50% and salicylic acid 30% peeling in the treatment of mild to moderate acne. MATERIALS AND METHODS: In a prospective single-blinded clinical trial, 86 patients with acne were randomly assigned into two groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27900998/novel-mutations-in-psenen-gene-in-two-chinese-acne-inversa-families-manifested-as-familial-multiple-comedones-and-dowling-degos-disease
#20
Cheng Zhou, Guang-Dong Wen, Lwin Myint Soe, Hong-Jun Xu, Juan Du, Jian-Zhong Zhang
BACKGROUND: Acne inversa (AI), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent skin disease of the hair follicle. Familial AI shows autosomal-dominant inheritance caused by mutations in the γ-secretase genes. This study was aimed to identify the specific mutations in the γ-secretase genes in two Chinese families with AI. METHODS: In this study, two Chinese families with AI were investigated. All the affected individuals in the two families mainly manifested with multiple comedones, pitted scars, and a few inflammatory nodules on their face, neck, trunk, axilla, buttocks, upper arms, and thighs...
December 5, 2016: Chinese Medical Journal
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