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https://www.readbyqxmd.com/read/27905128/ehlers-danlos-syndrome-related-to-fkbp14-mutations-detailed-cutaneous-phenotype
#1
A C Bursztejn, M Baumann, D Lipsker
In 2012, a new Ehlers-Danlos (ED) variant, characterized by severe progressive kyphoscoliosis, neonatal myopathy and hearing loss, with normal urinary lysylpyridinoline to hydroxylysylpyridinoline ratio and most often a recurrent homozygous mutation in the FKBP14 gene, was reported. Because one of the major affected tissues in ED syndrome is the skin, recognition of the cutaneous features of this newly recognized EDS variant is important. We describe the cutaneous phenotype of an adolescent girl harbouring the recurrent homozygous FKBP14 mutation...
November 30, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27904577/comparison-the-effectiveness-of-pyruvic-acid-50-and-salicylic-acid-30-in-the-treatment-of-acne
#2
Fariba Jaffary, Gita Faghihi, Sara Saraeian, Sayed Mohsen Hosseini
BACKGROUND: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles and one of the most common skin diseases. The peeling method has been recently found to be effective for acne treatment. This study aimed to compare the efficacy of pyruvic acid 50% and salicylic acid 30% peeling in the treatment of mild to moderate acne. MATERIALS AND METHODS: In a prospective single-blinded clinical trial, 86 patients with acne were randomly assigned into two groups...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27900998/novel-mutations-in-psenen-gene-in-two-chinese-acne-inversa-families-manifested-as-familial-multiple-comedones-and-dowling-degos-disease
#3
Cheng Zhou, Guang-Dong Wen, Lwin Myint Soe, Hong-Jun Xu, Juan Du, Jian-Zhong Zhang
BACKGROUND: Acne inversa (AI), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent skin disease of the hair follicle. Familial AI shows autosomal-dominant inheritance caused by mutations in the γ-secretase genes. This study was aimed to identify the specific mutations in the γ-secretase genes in two Chinese families with AI. METHODS: In this study, two Chinese families with AI were investigated. All the affected individuals in the two families mainly manifested with multiple comedones, pitted scars, and a few inflammatory nodules on their face, neck, trunk, axilla, buttocks, upper arms, and thighs...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27875092/morphological-variability-of-demodex-cati-in-a-feline-immunodeficiency-virus-positive-cat
#4
Elien R L Taffin, Stijn Casaert, Edwin Claerebout, Thomas J J Vandekerkhof, Sophie Vandenabeele
CASE DESCRIPTION A 17-year-old FIV-positive cat was evaluated because of weight loss during the preceding few months. The cat had a weight loss of 0.5 kg (1.1 lb) during the last month. Because of its FIV-positive status, the cat was confined indoors. CLINICAL FINDINGS A large nonpruritic area of alopecia with hyperpigmentation and comedones was present on the right lateral aspect of the neck. The chin had diffuse alopecia and comedones. Mild alopecia was present on the dorsal aspect of the muzzle. Trichography and microscopic examination of acetate tape imprint preparations and skin scrapings revealed a very morphologically heterogeneous population of Demodex mites...
December 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27847545/efficacy-safety-and-dermal-tolerability-of-dapsone-gel-7-5-in-patients-with-moderate-acne-vulgaris-a-pooled-analysis-of-two-phase-3-trials
#5
Diane M Thiboutot, Leon Kircik, Amy McMichael, Fran E Cook-Bolden, Stephen K Tyring, David R Berk, Joan-En Chang-Lin, Vince Lin, Alexandre Kaoukhov
Objective: Assess efficacy and safety of once-daily topical dapsone gel, 7.5% compared with vehicle for treating acne vulgaris (acne). Design: A pooled analysis of data from two identically designed, randomized, double-blind, vehicle-controlled, multicenter, 12-week clinical trials. Setting: Study sites in the United States and Canada. Participants: overall, 4,340 patients were randomized 1:1 to dapsone and vehicle. Criteria included age 12 years or older with acne diagnosis, 20 to 50 facial inflammatory lesions (papules and pustules), 30 to 100 facial noninflammatory lesions (open and closed comedones), and acne grade of 3 (moderate) on the Global Acne Assessment Score scale...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27816123/consensus-based-acne-classification-system-and-treatment-algorithm-for-spain
#6
J L López-Estebaranz, P Herranz-Pinto, B Dréno
Acne is a chronic inflammatory disease whose psychosocial effects can greatly impair quality of life. Various scales are used to classify the severity of acne, and several treatment algorithms are currently applied: no consensus on a common scale or treatment guidelines has been reached. A group of Spanish experts therefore met to identify a scale the majority could accept as the most appropriate for classifying severity and treating accordingly. The group chose the following classifications: comedonal acne, mild or moderate papulopustular acne, severe papulopustular acne, moderate nodular acne, and nodular-cystic acne (or acne tending to leave scars)...
November 2, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27762647/clinical-comparison-of-salicylic-acid-peel-and-led-laser-phototherapy-for-the-treatment-of-acne-vulgaris-in-teenagers
#7
Monique Narciso Alba, Marli Gerenutti, Valquíria Miwa Hanai Yoshida, Denise Grotto
Acne vulgaris treatments usually cause sensitivity, teratogenicity and bacterial resistance. Investigations of other therapeutic techniques, such as phototherapy, are highly relevant. Thus, we compared the effectiveness of two Acne vulgaris treatments in adolescents: peeling with salicylic acid (SA) and phototherapy. Teens were randomly divided into: group I, treatment with SA peels (10%) and group II, treatment with phototherapy (blue LED and red laser lights). Photographs were taken before and after ten sessions of each treatment, carried out weekly, and compared...
November 23, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27681360/targeting-of-sebaceous-glands-to-treat-acne-by-micro-insulated-needles-with-radio-frequency-in-a-rabbit-ear-model
#8
Tae-Rin Kwon, Eun Ja Choi, Chang Taek Oh, Dong-Ho Bak, Song-I Im, Eun Jung Ko, Hyuck Ki Hong, Yeon Shik Choi, Joon Seok, Sun Young Choi, Gun Young Ahn, Beom Joon Kim
BACKGROUND AND OBJECTIVES: Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a micro-insulated needle RF applicator in a rabbit ear acne (REA) model. STUDY DESIGN/MATERIALS AND METHODS: In this study, we investigated the effect of selectively destroying the sebaceous glands using a micro-insulated needle RF applicator on the formation of comedones induced by application of 50% oleic acid and intradermal injection of P...
September 29, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27630934/intense-pulsed-light-versus-1-064-long-pulsed-neodymium-yttrium-aluminum-garnet-laser-in-the-treatment-of-facial-acne-vulgaris
#9
Essam Elden Mohamed, Khaled Tawfik, Mohamed Elsaie
INTRODUCTION: Laser and light-based procedures provide a good and safe modality for treatment of active acne lesions when used properly. AIM: To compare the clinical efficacy of intense pulsed light (IPL) versus 1,064 long-pulsed Neodymium:Yttrium-Aluminum- Garnet (Nd: YAG) in treatment of facial acne vulgaris. MATERIALS AND METHODS: Seventy four patients recruited between June 2013 and August 2014 was enrolled in this controlled, single-blind, split-face clinical trial...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27557589/jessner-s-solution-vs-30-salicylic-acid-peels-a-comparative-study-of-the-efficacy-and-safety-in-mild-to-moderate-acne-vulgaris
#10
Surabhi Dayal, Ashish Amrani, Priyadarshini Sahu, Vijay Kumar Jain
INTRODUCTION: Chemical peeling is a well-identified therapeutic modality for acne vulgaris (AV). Jessner's solution (JS) is a known peeling agent for acne since more than 100 years. Salicylic acid (SA) peel is a well-established peeling agent for acne. There is paucity of literature comparing the current peeling agents of choice, that is, SA with the older peeling agents, that is, JS for acne. OBJECTIVE: To compare the efficacy and safety of 30% SA vs. JS peels in treatment of mild-to-moderate facial acne in Indian patients...
August 25, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27529209/treatment-modalities-for-acne
#11
REVIEW
Lizelle Fox, Candice Csongradi, Marique Aucamp, Jeanetta du Plessis, Minja Gerber
Acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. It can have severe psychological effects and can leave the patient with severe skin scarring. There are four well-recognized pathological factors responsible for acne which is also the target for acne therapy. In this review, different treatment options are discussed, including topical (i.e., retinoids, and antibiotics) and systemic (i.e., retinoids, antibiotics, and hormonal) treatments. Since the general public has been showing an increasing interest in more natural and generally safer treatment options, the use of complementary and alternative medicines (CAM) for treating acne was also discussed...
August 13, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27498658/successful-treatment-of-mild-to-moderate-acne-vulgaris-with-dr-michaels%C3%A2-also-branded-as-zitinex%C3%A2-topical-products-family-a-clinical-trial
#12
U Wollina, M Tirant, P Bayer, M Coburn, P Anderson, B Donnelly, T Kennedy, J Gaibor, M Arora, L Clews, S Walmsley, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Acne vulgaris is an epidemic inflammatory skin disease of multi-factorial origin, frequently seen in adolescents and often persisting or occurring through to adulthood. Acne vulgaris is a nearly universal skin disease afflicting 79-95% of the adolescent population in westernized societies and is a significant cause of psychological morbidity in affected patients. Despite the various treatment options available for acne, there is still a need for a safe and effective option. The aim of the study was to investigate the efficacy and tolerability of Dr Michaels® (Zitinex®) product family in the treatment of papulo-pustular acne...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27484346/new-effective-azelaic-acid-liposomal-gel-formulation-of-enhanced-pharmaceutical-bioavailability
#13
E Burchacka, P Potaczek, P Paduszyński, K Karłowicz-Bodalska, T Han, S Han
Azelaic acid is a naturally occurring saturated C9-dicarboxylic acid which has been shown to be effective in the treatment of comedonal acne and inflammatory acne, as well as hiperpigmentary skin disorders. The aim of the present study is to compare new developed liposomal hydrogel (lipogel) and commercially available product in terms of the active substance-azelaic acid bioavailability. Topical formulations were evaluated for physical parameters, such as pH measurement, organoleptic evaluation and liposome size analysis in lipogel formulation...
July 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27470329/birt-hogg-dub%C3%A3-syndrome-presenting-as-a-nevus-comedonicus-like-lesion-in-an-8-year-old-boy
#14
Jessica Sprague, Joseph W Landau
Birt-Hogg-Dubé syndrome is an uncommon genodermatosis characterized by hair follicle hamartomas and an increased risk of pneumothorax and renal cell carcinoma. Recognition of cutaneous manifestations is essential because it allows for early screening and management of systemic complications. We present the case of an 8-year-old boy with a recently described cystic and comedonal variant of the classic fibrofolliculoma, which had been present since birth.
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27421059/a-comparative-study-of-mmp-1-mmp-2-and-tnf-%C3%AE-expression-in-different-acne-vulgaris-lesions
#15
Seyma Ozkanli, Ayse Serap Karadag, Emin Ozlu, Tugba Kevser Uzuncakmak, Zennure Takci, Ebru Zemheri, Ilkin Zindancı, Necmettin Akdeniz
Many inflammatory mediators and cytokines play important roles in the pathogenesis of acne vulgaris (AV). Information about the roles of these factors in the pathogenesis of the disease is limited. The purpose of this study was to evaluate levels of matrix metalloproteinase-1 (MMP-1), MMP-2, and tumor necrosis factor-α (TNF-α) in AV lesions. We selected 80 patients who presented at our dermatology department with AV. Their lesions included papules, pustules, nodules, and comedones. Each specimen was evaluated by histopathology with hematoxylin and eosin staining, and subsequently by immunohistochemical analysis for MMP-1, MMP-2, and TNF-α antibodies...
July 15, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27400809/epidemiology-of-post-adolescence-acne-and-adolescence-acne-in-singapore-a-10-year-retrospective-and-comparative-study
#16
X D Han, H H Oon, C L Goh
INTRODUCTION: Acne vulgaris commonly affects adolescents. But recent reports suggest a rising prevalence of post-adolescence acne. While there are few reports on post-adolescence acne, there are even fewer reports comparing adolescence acne and post-adolescence. METHODS: Epidemiological data of adolescence (<25 years) and post-adolescence (≥25 years) acne patients diagnosed between 2004 and 2013 in a tertiary dermatology referral centre was analysed. From the pool of patients seen in 2010, 80 adolescence and 84 post-adolescence acne patients' epidemiological characteristics and treatment responses were analysed...
July 12, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27272089/failure-of-anakinra-in-a-case-of-severe-hidradenitis-suppurativa
#17
Veronica Russo, Ali Alikhan
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, painful, inflammatory disorder of hair follicles and manifests with several cutaneous findings, including double comedones, papules, cysts, nodules, draining abscesses, and sinus tracts. It is associated with tremendous morbidity and decreased quality of life. Treatment of HS is challenging. Recently, there have been mixed reports regarding the efficacy of anakinra, an interleukin 1 receptor antagonist, in the management of HS.<br/> CASE: A 55-year-old African American male with a several year history of severe HS, recalcitrant to multiple prior treatments, was treated with a 12 week course of anakinra 100 mg subcutaneously daily...
June 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27216488/evaluation-of-anti-acne-property-of-purified-bee-venom-serum-in-humans
#18
Sang Mi Han, Sok Cheon Pak, Young Mee Nicholls, Nicola Macfarlane
OBJECTIVE: Acne vulgaris is a chronic dermatologic disease with four factors involved in the development of lesions. Treatments need to address as many of these underlying factors as possible in order to reduce acne lesions. As such, purified bee venom (PBV(™) ) serum is an attractive therapeutic option for acne, but little data exist on the efficacy of this treatment strategy. METHODS: In this prospective, noncomparative study, 30 subjects having mild-to-moderate acne vulgaris were enrolled and treated with PBV(™) serum twice daily for a period of 6 weeks...
May 24, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27207185/treatment-of-axillary-bromhidrosis-through-a-mini-incision-with-subdermal-vascular-preservation-a-retrospective-study-in-396-patients
#19
Hengguang Zhao, Shuang Li, Owais Nabi, Li Hu, Xi Gao, Fuling Luo
BACKGROUND: Axillary bromhidrosis is a condition presenting as malodor caused by an interaction between the discharge of apocrine glands and bacteria. Topical agents, liposuction, and elective surgery are currently the main therapeutic modalities. However, the efficiency of these treatments and incidences of side effects are various and frequent, and depend on patient characteristics, surgical technique, and other unknown factors. METHODS: We report a retrospective study of outcomes in 396 patients treated by mini-incision with subdermal vascular preservation...
August 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27177989/a-consensus-based-practical-and-daily-guide-for-the-treatment-of-acne-patients
#20
H P Gollnick, V Bettoli, J Lambert, E Araviiskaia, I Binic, C Dessinioti, I Galadari, R Ganceviciene, N Ilter, M Kaegi, L Kemeny, J L López-Estebaranz, A Massa, C Oprica, W Sinclair, J C Szepietowski, B Dréno
BACKGROUND: Many current guidelines provide detailed evidence-based recommendations for acne treatment. OBJECTIVE: To create consensus-based, simple, easy-to-use algorithms for clinical acne treatment in daily office-based practice and to provide checklists to assist in determining why a patient may not have responded to treatment and what action to take. METHODS: Existing treatment guidelines and consensus papers were reviewed. The information in them was extracted and simplified according to daily clinical practice needs using a consensus-based approach and based on the authors' clinical expertise...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
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