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https://www.readbyqxmd.com/read/29137071/a-comparative-study-of-biological-and-metabolic-biomarkers-between-healthy-individuals-and-patients-with-acne-vulgaris-a-cross-sectional-study-protocol
#1
Kyuseok Kim, Injin Ha, Eunok Kim, Kyunglee Kim
Acne is a multifactorial dermatosis, which is influenced not only by hormones but also by the biochemical relationship between them and the pilosebaceous unit. Inflammatory cytokines, chemokines, active oxygen, and zinc are known to be associated with the development of acne. Further, steroid metabolism is known as one of the important factors related to sebum secretion and comedone formation in acne. However, there is a lack of studies comparing these human biomarkers between healthy individuals and patients with acne...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29118526/panfolliculoma-a-clinical-case-report
#2
Roberto Estrada-Castañón, María Elisa Vega-Memije, Juan Carlos Cuevas-González, María de Guadalupe Chávez-López
Panfolliculoma is a benign neoplasm of follicular differentiation, and its morphological characteristics are similar to those of trichoblastoma, but it shows greater follicular differentiation. A 55-year-old female patient, visited for a dermatological consultation, presented comedo-like lesions on the eyelids, which were accompanied by moderate pruritus that spread gradually. On examination, the patient had localized dermatosis on the face, which symmetrically affected both upper eyelids and to a lesser extent the lower eyelids...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29084194/-diet-in-pathogenesis-of-acne-vulgaris
#3
REVIEW
Katarzyna Ozdarska, Karolina Osucha, Stepan Savitskyi, Jacek Malejczyk, Ryszard Galus
Acne vulgaris is one of the most common dermatologic condition especially among adolescents. Acne is related to excess sebum production by sebaceous glands, inflammation both within and adjacent to the comedones, hyperproliferation of Propionibacterium acnes. Some of investigations show association between acne and diet. Milk increases the level of IGF-1 leading to the synthesis of androgen-mediated increases sebum production. Chocolate predispose to hyperglycemia and insulinemia which aggravate of acne vulgaris...
October 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29024079/the-preadolescent-acne-microbiome-a-prospective-randomized-pilot-study-investigating-characterization-and-effects-of-acne-therapy
#4
Carrie C Coughlin, Shane M Swink, Joseph Horwinski, Georgia Sfyroera, Julia Bugayev, Elizabeth A Grice, Albert C Yan
BACKGROUND/OBJECTIVES: Acne, a common pediatric disease, tends to be more comedonal in preadolescents, whereas older individuals are more likely to have inflammatory lesions in addition to comedones. Thus the microbiome of preadolescents may be different. In this pilot study we aimed to characterize the preadolescent acne microbiome, compare the microbiome in preadolescents with and without acne, and investigate changes in the microbiome after topical treatment with benzoyl peroxide or a retinoid in a small cohort of preadolescents...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28954114/multiple-vulvar-dilated-pores-in-a-postmenopausal-woman
#5
Ge Shi, Wei Li, Ni Liang, Ting-Ting Wang, Ying Zhou, Yi-Ming Fan
Winer's dilated pore is an infrequent appendageal tumor characterized by a giant comedone on the face, neck, and upper trunk in adults. We report a 57-year-old woman who developed multiple asymptomatic black papules on both labia majora. Histopathology showed grouped dilated follicles lined by keratinizing squamous epithelium in the superficial dermis. The superficial lining epithelium and interfollicular epidermis were atrophic, while the deep epithelium showed mild proliferation and melanin pigmentation with a few short projections extending into the surrounding dermis...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28859748/isotretinoin-and-surgical-extraction-for-adult-onset-nevus-comedonicus
#6
Joanna Dong, Robert G Phelps, Jacob Levitt
We present a case of postmenopausal-onset nevus comedonicus in a 58-year-old white woman with no relevant medical history. Two years before presentation, the patient had had a solitary red nodule, measuring 3.8 cm wide, on the mid lateral region of her left thigh. This progressed to a large area, 11.4 cm wide and 14 cm long, of multiple pruritic and painful red nodules, cysts, and deep open comedones extending across the lateral part of the left thigh, with less severe segmental extension to the lateral aspect of the left leg...
2017: Skinmed
https://www.readbyqxmd.com/read/28857716/chronic-cutaneous-lupus-erythematosus-presenting-as-atypical-acneiform-and-comedonal-plaque-case-report-and-literature-review
#7
M L Vieira, E R M C Marques, Y L A Leda, L F Noriega, D L Bet, G A A M Pereira
Introduction Chronic cutaneous lupus erythematosus (CCLE) usually presents as characteristic erythematous patches and infiltrated coin-shaped plaques. However, there are some atypical clinical variants that may mimic other dermatological conditions. Haroon et al. reported in 1972 an unusual presentation of CCLE with hypertrophic follicular scars seen in acne vulgaris. Acneiform presentation is one of the most rarely reported and one of the most confusing, as it resembles a very common inflammatory skin disease...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28794543/synchronizing-pharmacotherapy-in-acne-with-review-of-clinical-care
#8
REVIEW
Sarvajnamurthy Aradhya Sacchidanand, Koushik Lahiri, Kiran Godse, Narendra Gajanan Patwardhan, Anil Ganjoo, Rajendra Kharkar, Varsha Narayanan, Dhammraj Borade, Lyndon D'souza
Acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of Propionibacterium acnes, and inflammation. Several acne mono-treatment and combination treatment regimens are available and prescribed in the Indian market, ranging from retinoids, benzoyl peroxide (BPO), anti-infectives, and other miscellaneous agents. Although standard guidelines and recommendations overview the management of mild, moderate, and severe acne, relevance and positioning of each category of pharmacotherapy available in Indian market are still unexplained...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28686778/a-randomized-controlled-study-of-a-novel-botanical-acne-spot-treatment
#9
Deganit Barak-Shinar, Zoe Diana Draelos
<p>OBJECTIVE: The study evaluated the tolerability and efficacy of a new presented treatment for acne. The product is an OTC topical gel consisting of 2% SA, which is also enriched in botanicals that have been shown to have anti-inflammatory properties.</p> <p>DESIGN: The study was designed as a single-site, randomized, investigator-blinded, split-face 10-day study.</p> <p>SETTING: Subjects enrolled with a minimum of 2 inflammatory papular acne lesions and 2 non-inflammatory open or closed comedones on both sides of the face in symmetrical locations, to the greatest degree possible...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686774/prospective-study-of-pathogenesis-of-atrophic-acne-scars-and-role-of-macular-erythema
#10
Jerry Tan, Valérie Bourdès, Robert Bissonnette, Laurent Petit B Eng, Philippe Reynier, Amir Khammari, Brigitte Dreno
<p>BACKGROUND: There are few studies on the natural history of acne lesions including the antecedents of atrophic scars.</p> <p>STUDY DESIGN: Prospective study of relationship between primary (papules, pustules, comedones) and secondary lesions (atrophic scars, macular erythema, and hyperpigmentation) over 6 months. Subjects (n=32) had moderate facial acne including 10 or more atrophic acne scars and were their own control via randomized split-face design. Lesions were mapped 2x/week for 2 months and every 2 weeks thereafter until month 6 to track pathogenic progression...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28677199/acne
#11
Klaus Degitz, Falk Ochsendorf
Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF-1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28639579/postherpetic-comedones-in-two-chinese-han-patients
#12
Bo Wang, Jie Zheng, Hong-Wei Wang
No abstract text is available yet for this article.
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28594082/acneiform-eruptions-caused-by-vitamin-b12-a-report-of-five-cases-and-review-of-the-literature
#13
Stefano Veraldi, Susanna Benardon, Marco Diani, Mauro Barbareschi
We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. or oral vitamin B12. Clinical picture was characterized by papules and pustules located on the face. In three patients, similar lesions were also present on the neck, shoulders, chest, and upper portion of the back. Comedones and cysts were absent. In two patients, serum vitamin B12 levels were very high...
June 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28538881/efficacy-and-safety-of-superficial-chemical-peeling-in-treatment-of-active-acne-vulgaris
#14
REVIEW
Hassanain Al-Talib, Alyaa Al-Khateeb, Ayad Hameed, Chandrika Murugaiah
Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28369875/a-randomized-double-blind-placebo-controlled-trial-to-determine-the-efficacy-and-safety-of-lactoferrin-with-vitamin-e-and-zinc-as-an-oral-therapy-for-mild-to-moderate-acne-vulgaris
#15
Heidi Chan, Gertrude Chan, Joyce Santos, Kennie Dee, Juliene Kimberly Co
Lactoferrin is an iron-binding milk-derived protein that has shown antibacterial and anti-inflammatory effects in vitro and in vivo. The objective of this study was to determine the efficacy and safety of lactoferrin, combined with vitamin E and zinc, for mild to moderate acne vulgaris. In this randomized, double-blind, placebo-controlled trial, 168 subjects aged 13-40 years old were randomly assigned to take either a capsule formulation containing lactoferrin with vitamin E and zinc or placebo twice a day for 3 months...
June 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28358171/secondary-comedones-in-a-case-of-acne-conglobata-correlate-with-double-ended-pseudocomedones-in-hidradenitis-suppurativa
#16
Francesco Lacarrubba, Federica Dall'Oglio, Maria Letizia Musumeci, Maria Rita Nasca, Giuseppe Micali
No abstract text is available yet for this article.
August 31, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28342238/a-peel-off-facial-mask-comprising-myoinositol-and-trehalose-loaded-liposomes-improves-adult-female-acne-by-reducing-local-hyperandrogenism-and-activating-autophagy
#17
Gabriella Fabbrocini, Claudia Capasso, Marianna Donnarumma, Mariateresa Cantelli, Michel Le Maître, Giuseppe Monfrecola, Enzo Emanuele
BACKGROUND: Hyperandrogenism and reduced skin autophagy have been implicated in the pathogenesis of adult female acne (AFA). Here, we tested whether a ready-to-use peel-off facial mask containing myoinositol (an androgen inhibitor) and trehalose-loaded liposomes (as activators of cutaneous autophagy) applied overnight every other day for 60 days can improve AFA. We also sought to investigate the molecular mechanisms underlying the clinical effects. OBJECTIVES: We conducted an uncontrolled, open-label clinical study in 40 cases of AFA to investigate the effect of the facial mask on lesion count, sebum production (measured with the Sebutape® technique), and Global Acne Grading System (GAGS) scale...
March 25, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28293556/generalized-comedones-acne-and-hidradenitis-suppurativa-in-a-patient-with-an-fgfr2-missense-mutation
#18
Rebecca Higgins, Andrew Pink, Robert Hunger, Nikhil Yawalkar, Alexander A Navarini
Mutations in the fibroblast growth factor-receptor gene 2 (FGFR2) gene have been implicated in numerous diseases, including nevus comedonicus (NC) and naevoid acne that have somatic missense mutations in FGFR2 in the affected tissue. A patient presented in our department with unusual, innumerable large comedones throughout his back reminiscient of NC, as well as multifocal hidradenitis suppurativa and acne. Topical and systemic treatments were unsuccessful. Whole exome sequencing of blood-derived DNA detected a germline mutation in FGFR2 that was predicted to be damaging...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28274355/topical-treatments-for-acne
#19
Marita Kosmadaki, Andreas Katsambas
Topical drugs have been used successfully to treat acne for decades. This review discusses the use, efficacy, and safety of options available via prescription. Topical antibiotics, dapsone, benzyl peroxide, azelaic acid, and topical retinoids are included. Topical antibiotics should not be used as monotherapy but rather be combined with other agents to avoid resistant Propionibacterium acnes strains. Benzoyl peroxide is effective in preventing bacteria resistance. Topical retinoids address primarily the comedonal but also the inflammatory lesions of acne...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28251894/characteristics-of-premenstrual-acne-flare-up-and-benefits-of-a-dermocosmetic-treatment-a-double-blind-randomised-trial
#20
RANDOMIZED CONTROLLED TRIAL
Mélanie Saint-Jean, Amir Khammari, Sophie Seite, Dominique Moyal, Brigitte Dreno
To date, facial acne flare-ups in adult women during the luteal phase of the menstrual cycle have been poorly investigated. To clinically characterize premenstrual acne flare-up in adult women and investigate the effect of a dermocosmetic treatment. This single-centre study included 32 young adult women with declared premenstrual acne flares and was composed of two phases: (1) an observational phase (two menstrual cycles) and (2) an interventional phase (one menstrual cycle) in a controlled, randomised, double-blind, intra-individual (half-face) setting in which a dermocosmetic (containing lipohydroxyacid, nicotinamide, and piroctone-olamine) and placebo were compared...
April 1, 2017: European Journal of Dermatology: EJD
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