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https://www.readbyqxmd.com/read/28335527/metabolic-disorder-in-chronic-obstructive-pulmonary-disease-copd-patients-towards-a-personalized-approach-using-marine-drug-derivatives
#1
REVIEW
Palma Lamonaca, Giulia Prinzi, Aliaksei Kisiliaou, Vittorio Cardaci, Massimo Fini, Patrizia Russo
Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease (COPD) patients. However, the exact correlation between obesity, which is a complex metabolic disorder, and COPD remains controversial. The current study summarizes a variety of drugs from marine sources that have anti-obesity effects and proposed potential mechanisms by which lung function can be modulated with the anti-obesity activity. Considering the similar mechanism, such as inflammation, shared between obesity and COPD, the study suggests that marine derivatives that act on the adipose tissues to reduce inflammation may provide beneficial therapeutic effects in COPD subjects with high body mass index (BMI)...
March 20, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28317846/serum-and-synovial-fluid-lipidomic-profiles-predict-obesity-associated-osteoarthritis-synovitis-and-wound-repair
#2
Chia-Lung Wu, Kelly A Kimmerling, Dianne Little, Farshid Guilak
High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and wound healing in a pre-clinical obese mouse model of OA. Male C57BL/6 J mice were fed either a low-fat (10% kcal) or one of three high-fat (HF, 60% kcal) diets rich in saturated fatty acids (SFAs), ω-6 or ω-3 polyunsaturated FAs (PUFAs). OA was induced by destabilization of the medial meniscus...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28316156/-risk-factors-of-pulmonary-embolism-in-senile-and-non-senile-inpatients-and-the-predictive-value-of-caprini-risk-assessment-model-in-these-two-populations
#3
Y Chen, H X Zhou, Y H Hu, T X Cong, Y J Tang, L Wang, M Y Wang, Q Yi, Z A Liang
Objective: To investigate the risk factors of pulmonary embolism (PE) in senile and non-senile inpatients, and evaluate the predictive value of Caprini risk assessment model in these two populations. Methods: Case control study design was used in this study. All the PE patients diagnosed in West China Hospital of Sichuan University between January 2012 and December 2014 was included and divided into senile PE group (age ≥65 years old) and non-senile PE group (age <65 years old). Age matched controls (senile control group and non-senile control group) were selected from the patients admitted into the same departments during the same time period as PE patients, at a ratio of 2∶1...
March 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28315009/severe-underweight-decreases-the-survival-rate-in-adult-lung-transplantation
#4
Teruya Komatsu, Toyofumi F Chen-Yoshikawa, Ayako Oshima, Shin-Ichi Harashima, Akihiro Aoyama, Nobuya Inagaki, Hiroshi Date
PURPOSE: The body mass index (BMI) before lung transplantation (LT) is a benchmark of the post-LT survival. The aim of the study is to determine the BMI inadequate for the post-LT survival. METHODS: We examined the survival after LT in patients grouped into the following BMI categories: <18.5 kg/m(2) (underweight), 18.5-24.9 kg/m(2) (normal weight), 25-29.9 kg/m(2) (overweight), and ≥30.0 kg/m(2) (obese) according to the World Health Organization (WHO) criteria...
March 17, 2017: Surgery Today
https://www.readbyqxmd.com/read/28314081/delirium-after-lung-transplantation-association-with-recipient-characteristics-hospital-resource-utilization-and-mortality
#5
Yelizaveta Sher, Joshua Mooney, Gundeep Dhillon, Roy Lee, José R Maldonado
BACKGROUND: Delirium is associated with increased morbidity and mortality. The factors associated with post-lung transplant delirium and its impact on outcomes are under characterized. METHODS: The medical records of 163 consecutive adult lung transplant recipients were reviewed for delirium within 5 days (early-onset) and 30 hospital days (ever-onset) post-transplantation. A multivariable logistic regression model assessed factors associated with delirium. Multivariable negative binomial regression and Cox proportional hazards models assessed the association of delirium with ventilator duration, intensive care unit (ICU) length of stay (LOS), hospital LOS and one-year mortality...
March 17, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28302993/content-analysis-of-news-coverage-on-cancer-prevention-and-screening-in-japanese-newspapers
#6
Rina Miyawaki, Kaori Ishii, Ai Shibata, Koichiro Oka
Objectives The present study investigated articles on cancer prevention published in Japanese newspapers in 2011.Methods A content analysis of news coverage on cancer primary prevention and screening was conducted. Articles which mentioned cancer risk, prevention, and screening were extracted. For all articles on prevention, the newspaper's name, month of publication, and information source were checked. Coding variables for articles on primary prevention included causes of human cancer, risk and/or prevention, and recommended screening criteria...
2017: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
https://www.readbyqxmd.com/read/28298897/plasma-ghrelin-levels-are-associated-with-anorexia-but-not-cachexia-in-patients-with-nsclc
#7
Susanne Blauwhoff-Buskermolen, Jacqueline A E Langius, Annemieke C Heijboer, Annemarie Becker, Marian A E de van der Schueren, Henk M W Verheul
Background and Aims: The ghrelin receptor is one of the new therapeutic targets in the cancer anorexia-cachexia syndrome. Previous studies revealed that plasma ghrelin levels were high in patients with anorexia nervosa and low in obese subjects. We studied to what extent ghrelin levels are related with anorexia and cachexia in patients with cancer. Materials and Methods: Fasted ghrelin levels were determined as well as anorexia and cachexia in patients with stage III/IV non-small cell lung cancer before chemotherapy...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28298763/effect-of-switching-between-pressure-controlled-and-volume-controlled-ventilation-on-respiratory-mechanics-and-hemodynamics-in-obese-patients-during-abdominoplasty
#8
Medhat Mikhail Messeha
BACKGROUND: The ideal intraoperative ventilation strategy in obese patients remains obscure. This prospective, randomized study was designed to evaluate the effect of pressure-controlled ventilation (PCV) before or after volume-controlled ventilation (VCV) on lung mechanics and hemodynamics variables in obese patients subjected to abdominoplasty operation. PATIENTS AND METHODS: The study included forty patients with body mass index 30-45 kg/m(2) subjected to abdominoplasty...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28293621/development-of-the-physical-activity-and-your-nutrition-for-cancer-pync-smartphone-app-for-preventing-breast-cancer-in-women
#9
Steven S Coughlin, Gina M Besenyi, Deborah Bowen, Gianluca De Leo
BACKGROUND: In the U.S., breast cancer accounts for more cancer deaths in women than any site other than lung cancer. Based upon attributable risks, about 30-35% of breast cancers could potentially be prevented by addressing obesity, physical inactivity, increased alcohol consumption, and carcinogenic exposures such as hormone replacement therapy (HRT). We need methods of reducing women's risks of this disease that are attractive and easy to use, widely accessible to diverse women, and able to be easily amended to account for new research...
2017: MHealth
https://www.readbyqxmd.com/read/28284316/the-effects-of-obesity-on-lung-volumes-and-oxygenation
#10
Stephen W Littleton, Aiman Tulaimat
INTRODUCTION: Obesity can cause hypoxemia by decreasing lung volumes to where there is closure of lung units during normal breathing. Studies describing this phenomenon are difficult to translate into clinical practice. We wanted to determine the lung volume measurements that are associated with hypoxemia in obese patients, and explore how we could use these measurements to identify them. METHODS: We collected pulmonary function test results and arterial blood gas data on 118 patients without obstruction on pulmonary function testing...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28282907/complications-from-surgeries-related-to-ovarian-cancer-screening
#11
Lauren A Baldwin, Edward J Pavlik, Emma Ueland, Hannah E Brown, Kelsey M Ladd, Bin Huang, Christopher P DeSimone, John R van Nagell, Frederick R Ueland, Rachel W Miller
The aim of this study was to evaluate complications of surgical intervention for participants in the Kentucky Ovarian Cancer Screening Program and compare results to those of the Prostate, Lung, Colorectal and Ovarian Cancer Screening trial. A retrospective database review included 657 patients who underwent surgery for a positive screen in the Kentucky Ovarian Cancer Screening Program from 1988-2014. Data were abstracted from operative reports, discharge summaries, and office notes for 406 patients. Another 142 patients with incomplete records were interviewed by phone...
March 8, 2017: Diagnostics
https://www.readbyqxmd.com/read/28280320/the-effect-of-obesity-on-patients-with-mild-chronic-obstructive-pulmonary-disease-results-from-knhanes-2010-to-2012
#12
Ju-Hee Park, Jung-Kyu Lee, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung
PURPOSE: A low body mass index has been associated with high mortalities in patients with chronic obstructive pulmonary disease (COPD), and studies reveal that obesity aggravates the clinical effects of COPD. We investigated the impact of obesity on patients newly identified with COPD. PATIENTS AND METHODS: This population-based, cross-sectional study, used data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted from 2010 to 2012...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28278558/discriminatory-ability-of-visceral-adiposity-index-vai-in-diagnosis-of-metabolic-syndrome-a-population-based-study
#13
N Motamed, M R Khonsari, B Rabiee, H Ajdarkosh, G R Hemasi, M R Sohrabi, M Maadi, F Zamani
Background Visceral adiposity index (VAI) has been suggested as an index of visceral adiposity. This study was conducted to determine the discriminatory ability of VAI in diagnosis of metabolic syndrome (MetS). Methods and materials We used the data of 5 312 subjects aged 18-74 years of a cohort study conducted among 6 140 individuals aged 10-90 years in Amol, northern Iran. The city population was divided into 16 strata based on gender and age groups in 10-year intervals. The subjects were randomly selected from each stratum...
March 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28277743/obesity-induced-endoplasmic-reticulum-stress-causes-lung-endothelial-dysfunction-and-promotes-acute-lung-injury
#14
Dilip Shah, Freddy Romero, Zhi Guo, Jianxin Sun, Jonathan Li, Caleb B Kallen, Ulhas P Naik, Ross Summer
Obesity is a significant risk factor for the acute respiratory distress syndrome (ARDS). The mechanisms underlying this association are unknown. We recently showed that diet-induced obese (DIO) mice exhibit pulmonary vascular endothelial dysfunction which is associated with enhanced susceptibility to lipopolysaccharide (LPS)-induced lung injury. Here, we demonstrate that lung endothelial dysfunction in DIO mice coincides with increased endoplasmic reticulum (ER) stress. Specifically, we observed enhanced expression of the major sensors of misfolded proteins including PERK, IREα and ATF6, in whole lung and in lung endothelial cells isolated from DIO mice...
March 9, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28273875/characterization-of-ace-and-ace2-expression-within-different-organs-of-the-nod-mouse
#15
Heleia Roca-Ho, Marta Riera, Vanesa Palau, Julio Pascual, Maria Jose Soler
Renin angiotensin system (RAS) is known to play a key role in several diseases such as diabetes, and renal and cardiovascular pathologies. Its blockade has been demonstrated to delay chronic kidney disease progression and cardiovascular damage in diabetic patients. In this sense, since local RAS has been described, the aim of this study is to characterize angiotensin converting enzyme (ACE) and ACE2 activities, as well as protein expression, in several tissues of the non-obese diabetic (NOD) mice model. After 21 or 40 days of diabetes onset, mouse serums and tissues were analyzed for ACE and ACE2 enzyme activities and protein expression...
March 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28267354/body-size-specific-organ-and-effective-doses-of-chest-ct-screening-examinations-of-the-national-lung-screening-trial
#16
Choonsik Lee, Michael J Flynn, Phillip F Judy, Dianna D Cody, Wesley E Bolch, Randell L Kruger
OBJECTIVE: We calculated body size-specific organ and effective doses for 23,734 participants in the National Lung Screening Trial (NLST) using a CT dose calculator. MATERIALS AND METHODS: We collected participant-specific technical parameters of 23,734 participants who underwent CT in the clinical trial. For each participant, we calculated two sets of organ doses using two methods. First, we computed body size-specific organ and effective doses using the National Cancer Institute CT (NCICT) dosimetry program, which is based on dose coefficients derived from a library of body size-dependent adult male and female computational phantoms...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28265721/association-between-type-2-diabetes-and-risk-of-cancer-mortality-a-pooled-analysis-of-over-771-000-individuals-in-the-asia-cohort-consortium
#17
Yu Chen, Fen Wu, Eiko Saito, Yingsong Lin, Minkyo Song, Hung N Luu, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Yong-Bing Xiang, Yasutake Tomata, Kemmyo Sugiyama, Sue K Park, Keitaro Matsuo, Chisato Nagata, Yumi Sugawara, You-Lin Qiao, San-Lin You, Renwei Wang, Myung-Hee Shin, Wen-Harn Pan, Mangesh S Pednekar, Shoichiro Tsugane, Hui Cai, Jian-Min Yuan, Yu-Tang Gao, Ichiro Tsuji, Seiki Kanemura, Hidemi Ito, Keiko Wada, Yoon-Ok Ahn, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Paolo Boffetta, Wei Zheng, Manami Inoue, Daehee Kang, John D Potter
AIMS/HYPOTHESIS: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. METHODS: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia...
March 7, 2017: Diabetologia
https://www.readbyqxmd.com/read/28263381/obesity-promotes-prolonged-ovalbumin-induced-airway-inflammation-modulating-th1-th2-and-th17-immune-responses-in-balb-c-mice
#18
F M C Silva, E E Oliveira, A C C Gouveia, A S S Brugiolo, C C Alves, J O A Correa, J Gameiro, J Mattes, H C Teixeira, A P Ferreira
Clinical and epidemiological studies indicate that obesity affects the development and phenotype of asthma by inducing inflammatory mechanisms in addition to eosinophilic inflammation. The aim of this study was to assess the effect of obesity on allergic airway inflammation and T helper 2 (Th2) immune responses using an experimental model of asthma in BALB/c mice. Mice fed a high-fat diet (HFD) for 10 weeks were sensitized and challenged with ovalbumin (OVA), and analysis were performed at 24 and 48 hours after the last OVA challenge...
March 6, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28262207/sex-differences-in-the-effects-of-obesity-on-lung-volume
#19
Li Na Zhou, Qiong Wang, Chen Juan Gu, Ning Li, Jian Ping Zhou, Xian Wen Sun, Jun Zhou, Qing Yun Li
BACKGROUND: Obesity is linked to variation of lung volume; however, it is still unclear whether a sex difference exists. The study aimed to find out the effect of obesity on lung volume and sex difference among the Chinese population. METHOD: Pulmonary function test results were collected from 300 patients (aged 18 to ~80 years) with normal airway function and a wide range of body mass indexes (BMI). Measures of total lung capacity, vital capacity (VC), inspiratory capacity (IC), reserve volume, expiratory reserve volume (ERV) and functional reserve capacity (FRC) were analyzed by sex and different BMI groups...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28259595/donor-recipient-size-matching-and-mortality-in-heart-transplantation-influence-of-body-mass-index-and-gender
#20
Henrik Bergenfeldt, Josef Stehlik, Peter Höglund, Bodil Andersson, Johan Nilsson
BACKGROUND: The International Society for Heart and Lung Transplantation (ISHLT) guidelines advise against inappropriate weight match (IWM) for heart transplant, defined as donor weight <70% of recipient's weight. Few studies have explored in detail this size-matching recommendation, especially with regard to body mass index (BMI) and gender matching. We aimed to determine whether any difference could be observed between size-matching in obese and non-obese recipients with regard to mortality after cardiac transplantation...
February 3, 2017: Journal of Heart and Lung Transplantation
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