keyword
MENU ▼
Read by QxMD icon Read
search

obesity lung

keyword
https://www.readbyqxmd.com/read/28797888/the-weighty-issue-of-obesity-in-paediatric-respiratory-medicine
#1
REVIEW
Dominic A Fitzgerald
Some have observed that developed world is fat and getting fatter. This is even extending into the developing world, and it is important to appreciate that the consequences of childhood obesity last into adulthood and are associated with premature death. From the paediatric respiratory perspective, the deposition of excess adipose tissue in the thoraco-abdominal region begins early in life and is believed to alter diaphragm mobility and chest wall expansion, reduce lung compliance, and result in a rapid shallow breathing pattern with an increased work of breathing and reduction in maximum ventilatory capacity...
June 11, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28794957/prevalence-of-metabolic-syndrome-and-metabolic-syndrome-components-in-young-adults-a-pooled-analysis
#2
Paul B Nolan, Graeme Carrick-Ranson, James W Stinear, Stacey A Reading, Lance C Dalleck
Metabolic syndrome (MetSyn) represents a clustering of different metabolic abnormalities. MetSyn prevalence is present in approximately 25% of all adults with increased prevalence in advanced ages. The presence of one component of MetSyn increases the risk of developing MetSyn later in life and likely represents a high lifetime burden of cardiovascular disease risk. Therefore we pooled data from multiple studies to establish the prevalence of MetSyn and MetSyn component prevalence across a broad range of ethnicities...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28789683/voluntary-running-exercise-protects-against-sepsis-induced-early-inflammatory-and-pro-coagulant-responses-in-aged-mice
#3
Karel Tyml, Scott Swarbreck, Cynthia Pape, Dan Secor, James Koropatnick, Qingping Feng, Ruud A W Veldhuizen, Sean E Gill
BACKGROUND: Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic patients are elderly (60 - 70 years). The objective of the present study was to examine the sepsis-induced inflammatory and pro-coagulant responses in aged mice. Since running exercise protects against a variety of diseases, we also examined the effect of voluntary running on septic responses in aged mice...
August 8, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28783757/improving-food-environments-and-tackling-obesity-a-realist-systematic-review-of-the-policy-success-of-regulatory-interventions-targeting-population-nutrition
#4
Jana Sisnowski, Jackie M Street, Tracy Merlin
BACKGROUND: This systematic review (PROSPERO: CRD42015025276) employs a realist approach to investigate the effect of "real-world" policies targeting different aspects of the food environment that shape individual and collective nutrition. OBJECTIVES: We were interested in assessing intermediate outcomes along the assumed causal pathway to "policy success", in addition to the final outcome of changed consumption patterns. DATA SOURCES: We performed a search of 16 databases through October 2015, with no initial restriction by language...
2017: PloS One
https://www.readbyqxmd.com/read/28768612/short-term-efficacy-of-an-innovative-mobile-phone-technology-based-intervention-for-weight-management-for-overweight-and-obese-adolescents-pilot-study
#5
Jyu-Lin Chen, Claudia M Guedes, Bruce A Cooper, Audrey E Lung
BACKGROUND: In the United States, approximately one-third of adolescents are now overweight or obese, and one in six is obese. This financial cost and the larger nonfinancial costs of obesity make obesity prevention and management for adolescents imperative for the health of the nation. However, primary care visits are typically brief, and primary care providers may lack adequate resources to help overweight or obese adolescents to manage weight issues. To augment the efficacy of primary care visits for adolescent weight management, mobile phone technology can be used as an adjunct treatment that provides additional opportunities for encouraging improvement in lifestyle, attainment, and maintenance of healthy weight...
August 2, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28764134/exposure-to-polycyclic-aromatic-hydrocarbons-and-central-obesity-enhanced-risk-for-diabetes-among-individuals-with-poor-lung-function
#6
Jian Hou, Huizhen Sun, Xiji Huang, Yun Zhou, Youjian Zhang, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Some studies have shown an association between obesity or exposure to polycyclic aromatic hydrocarbons (PAHs) and the risk of diabetes. This study aimed to investigate the interaction of obesity and urinary monohydroxy-PAHs (OH-PAHs) on diabetes. Individuals (n = 2716) were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. They completed the physical examination, measurements of lung function, biochemical indices and urinary OH-PAHs levels. Additive effect of obesity and urinary ΣOH-PAHs levels on diabetes was assessed by calculating the relative excess risk due to interaction (RERI) and the attributable proportion (AP) due to interaction...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28759122/differential-effects-of-late-gestation-maternal-overnutrition-on-the-regulation-of-surfactant-maturation-in-fetal-and-postnatal-life
#7
Mitchell C Lock, Erin V McGillick, Sandra Orgeig, I Caroline McMillen, Beverly S Mühlhäusler, Song Zhang, Janna L Morrison
With the increasing incidence of obesity worldwide, the proportion of women entering pregnancy overweight or obese has increased dramatically. The fetus of an overnourished mother experiences numerous metabolic changes that may modulate lung development and hence successful transition to air-breathing at birth. We used a sheep model of maternal late gestation overnutrition (LGON; from 115 d gestation, term 147 ± 3 d) to determine the effect of exposure to an increased plane of nutrition in late gestation on lung development in the fetus (at 141 d gestation) and the lamb (30 d after birth)...
July 31, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28757418/obesity-paradox-in-lung-cancer-prognosis-evolving-biological-insights-and-clinical-implications
#8
REVIEW
Xueli Zhang, Yamin Liu, Hua Shao, Xiao Zheng
The survival rate of lung cancer remains low despite the progress of surgery and chemotherapy. With the increasing comorbidity of obesity in lung cancer patients, new challenges emerge in the management of this patient population. A key issue of interest is the prognostic effect of obesity on surgical and chemotherapeutical outcomes in lung cancer patients, which is fueled by the growing observation of survival benefits in overweight or obese patients. This unexpected inverse relation between obesity and lung cancer mortality, called 'obesity paradox', remains poorly understood...
July 27, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28753389/feasibility-of-dose-reduced-chest-ct-with-photon-counting-detectors-initial-results-in-humans
#9
Rolf Symons, Amir Pourmorteza, Veit Sandfort, Mark A Ahlman, Tracy Cropper, Marissa Mallek, Steffen Kappler, Stefan Ulzheimer, Mahadevappa Mahesh, Elizabeth C Jones, Ashkan A Malayeri, Les R Folio, David A Bluemke
Purpose To investigate whether photon-counting detector (PCD) technology can improve dose-reduced chest computed tomography (CT) image quality compared with that attained with conventional energy-integrating detector (EID) technology in vivo. Materials and Methods This was a HIPAA-compliant institutional review board-approved study, with informed consent from patients. Dose-reduced spiral unenhanced lung EID and PCD CT examinations were performed in 30 asymptomatic volunteers in accordance with manufacturer-recommended guidelines for CT lung cancer screening (120-kVp tube voltage, 20-mAs reference tube current-time product for both detectors)...
July 28, 2017: Radiology
https://www.readbyqxmd.com/read/28748811/the-obesity-paradox-what-does-it-mean-for-lung-cancer-surgery
#10
EDITORIAL
Emily Stone, Christopher G Slatore
No abstract text is available yet for this article.
August 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28748269/presence-of-bpifb1-in-saliva-from-non-obese-diabetic-mice
#11
Tomoko Nashida, Junko Shimomura-Kuroki, Fumi Mizuhashi, Maiko Haga-Tsujimura, Ken Yoshimura, Sachiko Hayashi-Sakai
We previously showed that mRNA expression of BPIFB1 (Bpifb1), an antibacterial protein in the palate, lung, and nasal epithelium clone protein family, was increased in parotid acinar cells in non-obese diabetic (NOD, NOD/ShiJcl) mice, which is an animal model for Sjögren's syndrome. However, we did not previously assess the protein levels. In this report, we confirmed the expression of BPIFB1 protein in the parotid glands of NOD mice. Immunoblotting of subcellular fractions revealed that BPIBB1 was localised in secretory granules in parotid glands from NOD mice, and was almost not in parotid glands from the control mice...
July 26, 2017: Odontology
https://www.readbyqxmd.com/read/28748213/metabolic-reprogramming-underlies-metastatic-potential-in-an-obesity-responsive-murine-model-of-metastatic-triple-negative-breast-cancer
#12
Ciara H O'Flanagan, Emily L Rossi, Shannon B McDonell, Xuewen Chen, Yi-Hsuan Tsai, Joel S Parker, Jerry Usary, Charles M Perou, Stephen D Hursting
The vast majority of cancer-related deaths are due to metastatic disease, whereby primary tumor cells disseminate and colonize distal sites within the body. Triple negative breast cancer typically displays aberrant Wnt signaling, lacks effective targeted therapies, and compared with other breast cancer subtypes, is more likely to recur and metastasize. We developed a Wnt-driven lung metastasis model of triple negative breast cancer (metM-Wnt(lung)) through serial passaging of our previously described, nonmetastatic, claudin-low M-Wnt cell line...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28743914/cyclic-gmp-amp-ameliorates-diet-induced-metabolic-dysregulation-and-regulates-proinflammatory-responses-distinctly-from-sting-activation
#13
Xin Guo, Chang Shu, Honggui Li, Ya Pei, Shih-Lung Woo, Juan Zheng, Mengyang Liu, Hang Xu, Rachel Botchlett, Ting Guo, Yuli Cai, Xinsheng Gao, Jing Zhou, Lu Chen, Qifu Li, Xiaoqiu Xiao, Linglin Xie, Ke K Zhang, Jun-Yuan Ji, Yuqing Huo, Fanyin Meng, Gianfranco Alpini, Pingwei Li, Chaodong Wu
Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to induce type I interferons. However, whether cGAMP plays any roles in regulating metabolic homeostasis remains unknown. Here we show that exogenous cGAMP ameliorates obesity-associated metabolic dysregulation and uniquely alters proinflammatory responses. In obese mice, treatment with cGAMP significantly decreases diet-induced proinflammatory responses in liver and adipose tissues and ameliorates metabolic dysregulation. Strikingly, cGAMP exerts cell-type-specific anti-inflammatory effects on macrophages, hepatocytes, and adipocytes, which is distinct from the effect of STING activation by DMXAA on enhancing proinflammatory responses...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740685/minimally-invasive-aortic-valve-replacement-in-high-risk-patient-groups
#14
REVIEW
Daniel Fudulu, Harriet Lewis, Umberto Benedetto, Massimo Caputo, Gianni Angelini, Hunaid A Vohra
Minimally invasive aortic valve replacement (AVR) aims to preserve the sternal integrity and improve postoperative outcomes. In low risk patients, this technique can be achieved with comparable mortality to the conventional approach and there is evidence of possible reduction in intensive care and hospital length of stay, transfusion requirement, renal dysfunction, improved respiratory function and increased patient satisfaction. In this review, we aim to asses if these benefits can be transferred to the high risk patient groups...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28737966/effect-of-obesity-on-sinonasal-disease-in-asthma
#15
S Kanagalingam, S S Shehab, D A Kaminsky, R A Wise, J E Lang, A E Dixon
Sinonasal disease can contribute to poor asthma control. There are reports that link obesity with an increased prevalence of sinonasal disease, but no studies evaluating the severity of sinonasal disease in obese asthmatics, and how this impacts asthma control. The purpose of the current study was to determine if obesity is associated with increased severity of sinonasal disease, and/or affects response to nasal corticosteroid treatment in asthma. METHODS: This study included 236 adults participating in a 24-week randomized, double-masked, placebo-controlled study of nasal mometasone for the treatment of poorly controlled asthma...
July 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28737771/obesity-alters-the-lung-myeloid-cell-landscape-to-enhance-breast-cancer-metastasis-through-il5-and%C3%A2-gm-csf
#16
Daniela F Quail, Oakley C Olson, Priya Bhardwaj, Logan A Walsh, Leila Akkari, Marsha L Quick, I-Chun Chen, Nils Wendel, Nir Ben-Chetrit, Jeanne Walker, Peter R Holt, Andrew J Dannenberg, Johanna A Joyce
Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast cancer metastasis to this site, in a GM-CSF- and IL5-dependent manner...
August 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28736826/impact-of-respiratory-motion-and-acquisition-settings-on-spect-liver-dosimetry-for-radioembolization
#17
Remco Bastiaannet, Max A Viergever, Hugo W A M de Jong
PURPOSE: Respiratory motion may impose significant inaccuracies on emission activity estimation in quantitative SPECT. This effect may be a major issue in dosimetry as used in management of liver radioembolization. The purpose of this study was to investigate the impact of respiratory motion on radioembolization liver dosimetry for different SPECT acquisition settings. METHODS: In a series of SPECT/CT Monte Carlo simulations using several digital XCAT phantoms, the following parameters were varied: breathing/non-breathing, liver tumor size (0...
July 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28728934/beyond-bmi-obesity-and-lung-disease
#18
REVIEW
Ubong Peters, Benjamin T Suratt, Jason H T Bates, Anne E Dixon
The worldwide prevalence of obesity has increased rapidly in the last 3 decades, and this increase has led to important changes in the pathogenesis and clinical presentation of many common diseases. This review article examines the relationship between obesity and lung disease, highlighting some of the major findings that have advanced our understanding of the mechanisms contributing to this relationship. Changes in pulmonary function related to fat mass are important, but obesity is much more than simply a state of mass loading, and BMI is only a very indirect measure of metabolic health...
July 17, 2017: Chest
https://www.readbyqxmd.com/read/28724854/improvement-of-pulmonary-function-after-comprehensive-obesity-rehabilitation-program-in-obese-patients
#19
Tamao Takahashi, Satoru Ebihara, Masahiro Kohzuki
Obesity is a major risk factor of cardiovascular, osteoarthritis, metabolic and pulmonary disorders, and exercise is an efficient method for treating obesity. However, obese patients often complain of dyspnea on exertion, which makes it difficult to continue exercise program. Obesity is also known to have an adverse effect on pulmonary function. The purpose of this study was to examine the effects of a comprehensive obesity rehabilitation (COR) program on pulmonary function in Japanese patients with morbid obesity...
July 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28722077/invasive-haemodynamic-evaluation-of-the-pulmonary-circulation-in-pulmonary-hypertension
#20
Alberto Pagnamenta, Andrea Azzola, Maurice Beghetti, Frédéric Lador, On Behalf Of The Swiss Society Of Pulmonary Hypertension
The term pulmonary hypertension refers to a serious condition characterised by high pulmonary vascular pressure, mainly as a consequence of various cardiac and respiratory diseases. Current clinical classification of pulmonary hypertension considers five distinct groups. Transthoracic echocardiography represents the first and most important noninvasive screening tool for estimating the probability of pulmonary hypertension. The diagnostic approach to pulmonary hypertension is supported by a proposed algorithm, which identifies the underlying cause...
July 19, 2017: Swiss Medical Weekly
keyword
keyword
39493
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"