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https://www.readbyqxmd.com/read/29663179/the-impact-of-obesity-on-pulmonary-deterioration-in-patients-undergoing-robotic-assisted-laparoscopic-prostatectomy
#1
Sebastian Blecha, Marion Harth, Florian Zeman, Timo Seyfried, Matthias Lubnow, Maximilian Burger, Stefan Denzinger, Michael T Pawlik
Obesity affects respiratory and hemodynamic function in anesthetized patients. The aim of this study was to evaluate the influence of the body mass index (BMI) on pulmonary changes in a permanent 45° steep Trendelenburg position (STP) during robotic-assisted laparoscopic prostatectomy (RALP). 51 patients undergoing RALP under standardized anesthesia were included. Perioperative pulmonary function and oxygenation were measured in awake patients (T0 ), 20 min after the induction of anesthesia (T1 ), after insufflation of the abdomen in supine position (T2 ), after 30 min in STP (T3 ), when controlling Santorini's plexus in STP (T4 ), before awakening while supine (T5 ), and after 45 min in the recovery room (T6 )...
April 16, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29627041/obesity-and-asthma
#2
REVIEW
Ubong Peters, Anne E Dixon, Erick Forno
Obesity is a vast public health problem and both a major risk factor and disease modifier for asthma in children and adults. Obese subjects have increased asthma risk, and obese asthmatic patients have more symptoms, more frequent and severe exacerbations, reduced response to several asthma medications, and decreased quality of life. Obese asthma is a complex syndrome, including different phenotypes of disease that are just beginning to be understood. We examine the epidemiology and characteristics of this syndrome in children and adults, as well as the changes in lung function seen in each age group...
April 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29621304/trends-in-congenital-anomalies-in-europe-from-1980-to-2012
#3
Joan K Morris, Anna L Springett, Ruth Greenlees, Maria Loane, Marie-Claude Addor, Larraitz Arriola, Ingeborg Barisic, Jorieke E H Bergman, Melinda Csaky-Szunyogh, Carlos Dias, Elizabeth S Draper, Ester Garne, Miriam Gatt, Babak Khoshnood, Kari Klungsoyr, Catherine Lynch, Robert McDonnell, Vera Nelen, Amanda J Neville, Mary O'Mahony, Anna Pierini, Annette Queisser-Luft, Hanitra Randrianaivo, Judith Rankin, Anke Rissmann, Jennifer Kurinczuk, David Tucker, Christine Verellen-Dumoulin, Diana Wellesley, Helen Dolk
BACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens. METHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. RESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing...
2018: PloS One
https://www.readbyqxmd.com/read/29619146/high-fat-diet-increases-hmgb1-expression-and-promotes-lung-inflammation-in-mice-subjected-to-mechanical-ventilation
#4
Ana Beatriz Farias de Souza, Máira Tereza Talma Chírico, Christiane Teixeira Cartelle, Guilherme de Paula Costa, André Talvani, Sílvia Dantas Cangussú, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
This study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice. Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet. After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG), and diet mechanical ventilation group (DMVG). MVG and DMVG underwent mechanical ventilation for 60 minutes...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29609450/hepatopulmonary-syndrome-caused-by-hypothalamic-obesity-and-nonalcoholic-fatty-liver-disease-after-surgery-for-craniopharyngioma-a-case-report
#5
Dai Jung, Go Hun Seo, Yoon-Myung Kim, Jin-Ho Choi, Han-Wook Yoo
Hypothalamic obesity is often complicated in patients with craniopharyngioma due to hypothalamic damage by the tumor itself, treatment modalities, and associated multiple pituitary hormone deficiency. Hypothalamic obesity causes secondary diseases such as nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM). We report a 19-year-old female who was diagnosed with craniopharyngioma, developed hypothalamic obesity after tumor resection, and progressed to hepatopulmonary syndrome. She manifested NAFLD 1 year after tumor resection...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29608145/intraperitoneal-glucose-tolerance-test-measurement-of-lung-function-and-fixation-of-the-lung-to-study-the-impact-of-obesity-and-impaired-metabolism-on-pulmonary-outcomes
#6
Katharina Dinger, Jasmine Mohr, Christina Vohlen, Dharmesh Hirani, Eva Hucklenbruch-Rother, Regina Ensenauer, Jörg Dötsch, Miguel A Alejandre Alcazar
Obesity and respiratory disorders are major health problems. Obesity is becoming an emerging epidemic with an expected number of over 1 billion obese individuals worldwide by 2030, thus representing a growing socioeconomic burden. Simultaneously, obesity-related comorbidities, including diabetes as well as heart and chronic lung diseases, are continuously on the rise. Although obesity has been associated with increased risk for asthma exacerbations, worsening of respiratory symptoms, and poor control, the functional role of obesity and perturbed metabolism in the pathogenesis of chronic lung disease is often underestimated, and underlying molecular mechanisms remain elusive...
March 15, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29606090/application-of-intraoperative-lung-protective-ventilation-varies-in-accordance-with-the-knowledge-of-anaesthesiologists-a-single-centre-questionnaire-study-and-a-retrospective-observational-study
#7
Seung Hyun Kim, Sungwon Na, Woo Kyung Lee, Hyunwoo Choi, Jeongmin Kim
BACKGROUND: The benefits of lung-protective ventilation (LPV) with a low tidal volume (6 mL/kg of ideal body weight [IBW]), limited plateau pressure (< 28-30 cm H2 O), and appropriate positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome have become apparent and it is now widely adopted in intensive care units. Recently evidence for LPV in general anaesthesia has been accumulated, but it is not yet generally applied by anaesthesiologists in the operating room...
April 2, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29605211/spirometric-impairments-cardiovascular-outcomes-and-noncardiovascular-death-in-older-persons
#8
Carlos A Vaz Fragoso, Peter H Van Ness, Terrence E Murphy, Gail J McAvay
BACKGROUND: In prior work involving older persons, the reported associations of spirometric impairments with cardiovascular outcomes may have been confounded by age-related changes in lung function. Hence, using more age-appropriate spirometric criteria from the Global Lung Function Initiative (GLI), we have evaluated the associations of spirometric impairments, specifically restrictive-pattern and airflow-obstruction, with cardiovascular death (CV-death) and hospitalization (CV-hospitalization)...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29590183/high-health-literacy-is-associated-with-less-obesity-and-lower-framingham-risk-score-sub-study-of-the-vgh-healthcare-trial
#9
Yuan-Lung Cheng, Jiah-Hwang Shu, Hsiu-Chuan Hsu, Ying Liang, Ruey-Hsing Chou, Pai-Feng Hsu, Yuan-Jen Wang, Yaw-Zon Ding, Teh-Ling Liou, Ying-Wen Wang, Shao-Sung Huang, Chung-Chi Lin, Tse-Min Lu, Hsin-Bang Leu, Shing-Jong Lin, Wan-Leong Chan
BACKGROUNDS: Lower health literacy (HL) is associated with several cardiovascular disease (CVD) risk factors such as diabetes, hypertension, and metabolic syndrome (MS). The aim of our study was to investigate the association between HL and the Framingham 10-year risk score of CVD. METHODS: From 2015-2016, 1010 subjects aged 23 to 88 years receiving health check-up in Taipei Veterans General Hospital had complete clinical evaluations and laboratory examinations...
2018: PloS One
https://www.readbyqxmd.com/read/29589109/prevalence-and-associated-factors-of-preoperative-functional-disability-in-elective-surgical-patients-over-55-years-old-a-prospective-cohort-study
#10
Mitsuru Ida, Yusuke Naito, Yasunori Matsunari, Yuu Tanaka, Satoki Inoue, Masahiko Kawaguchi
PURPOSE: In preoperative settings, patients may have functional disabilities due to the disease for which surgery is being performed or comorbidities, but the associated and predictive factors remain unknown. This study examined the prevalence of preoperative functional disability and clarified the associated factors. METHODS: Individuals aged ≥ 55 years who were scheduled to undergo surgery in a tertiary-care hospital in Japan between April 2016 and September 2016 were eligible for enrolment in the study...
March 27, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29587720/spontaneous-adrenocorticotropic-hormone-acth-normalisation-due-to-tumour-regression-induced-by-metyrapone-in-a-patient-with-ectopic-acth-syndrome-case-report-and-literature-review
#11
Hideyuki Iwayama, Sho Hirase, Yuka Nomura, Tatsuo Ito, Hiroyuki Morita, Kazuo Otake, Akihisa Okumura, Junko Takagi
BACKGROUND: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. CASE PRESENTATION: A 71-year-old female with general fatigue, central obesity and impaired glucose tolerance was diagnosed with Cushing's syndrome due to elevated ACTH (192...
March 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29574860/a-dietary-pattern-based-on-estrogen-metabolism-is-associated-with-breast-cancer-risk-in-a-prospective-cohort-of-postmenopausal-women
#12
Mark A Guinter, Alexander C McLain, Anwar T Merchant, Dale P Sandler, Susan E Steck
Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxylated estrogen metabolites in a subsample of Prostate, Lung, Colorectal and Ovarian Screening Trial (PLCO) participants (n=653) using reduced rank regression, and examined its association with postmenopausal breast cancer prospectively in the larger PLCO cohort (n=27,488)...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29574856/hu-deviation-in-lung-and-bone-tissues-characterization-and-a-corrective-strategy
#13
Hua A Ai, Joseph G Meier, Richard E Wendt
INTRODUCTION: In the era of precision medicine, quantitative applications of x-ray Computed Tomography (CT) are on the rise. These require accurate measurement of the CT number, also known as the Hounsfield Unit. In this study, we evaluated the effect of patient attenuation-induced beam hardening of the x-ray spectrum on the accuracy of the HU values and a strategy to correct for the resulting deviations in the measured HU values. MATERIALS AND METHODS: A CIRS electron density phantom was scanned on a Siemens Biograph mCT Flow CT scanner and a GE Discovery 710 CT scanner using standard techniques that are employed in the clinic to assess the HU deviation caused by beam hardening in different tissue types...
March 24, 2018: Medical Physics
https://www.readbyqxmd.com/read/29567982/the-fraction-of-cancer-attributable-to-modifiable-risk-factors-in-england-wales-scotland-northern-ireland-and-the-united-kingdom-in-2015
#14
Katrina F Brown, Harriet Rumgay, Casey Dunlop, Margaret Ryan, Frances Quartly, Alison Cox, Andrew Deas, Lucy Elliss-Brookes, Anna Gavin, Luke Hounsome, Dyfed Huws, Nick Ormiston-Smith, Jon Shelton, Ceri White, D Max Parkin
BACKGROUND: Changing population-level exposure to modifiable risk factors is a key driver of changing cancer incidence. Understanding these changes is therefore vital when prioritising risk-reduction policies, in order to have the biggest impact on reducing cancer incidence. UK figures on the number of risk factor-attributable cancers are updated here to reflect changing behaviour as assessed in representative national surveys, and new epidemiological evidence. Figures are also presented by UK constituent country because prevalence of risk factor exposure varies between them...
March 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29567055/long-term-follow-up-of-disease-specific-quality-of-life-after-bariatric-surgery
#15
Simon Biron, Laurent Biertho, Simon Marceau, Yves Lacasse
BACKGROUND: Substantial improvements in health-related quality of life measured by generic questionnaires (most often the Short Form-36) have been noted over the long term in patients with morbid obesity who had undergone bariatric surgery. OBJECTIVES: To obtain long-term follow-up data on disease-specific quality of life in patients who underwent bariatric surgery (biliopancreatic diversion with duodenal switch) in 2007 to 2008. SETTING: Québec Heart and Lung Institute, Québec, Canada...
February 13, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29565180/ablation-of-the-leptin-receptor-in-myeloid-cells-impairs-pulmonary-clearance-of-streptococcus-pneumoniae-and-alveolar-macrophage-bactericidal-function
#16
Peter Mancuso, Jeffrey L Curtis, Christine M Freeman, Marc Peters-Golden, Jason B Weinberg, Martin G Myers
Leptin is a pleiotropic hormone produced by white adipose tissue that regulates appetite and many physiologic functions including the immune response to infection. Genetic leptin deficiency in humans and mice impairs host defenses against respiratory tract infections. Since leptin deficiency is associated with obesity and other metabolic abnormalities, we generated mice that lack the leptin receptor (LepRb) in cells of the myeloid linage (LysM-LepRb-KO) to evaluate its impact in lean metabolically normal mice in a murine model of pneumococcal pneumonia...
March 22, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29561930/improvement-in-lung-function-and-functional-capacity-in-morbidly-obese-women-subjected-to-bariatric-surgery
#17
Elaine Cristina de Campos, Fabiana Sobral Peixoto-Souza, Viviane Cristina Alves, Renata Basso-Vanelli, Marcela Barbalho-Moulim, Rafael Melillo Laurino-Neto, Dirceu Costa
OBJECTIVE: To determine whether weight loss in women with morbid obesity subjected to bariatric surgery alters lung function, respiratory muscle strength, functional capacity and the level of habitual physical activity and to investigate the relationship between these variables and changes in both body composition and anthropometrics. METHODS: Twenty-four women with morbid obesity were evaluated with regard to lung function, respiratory muscle strength, functional capacity, body composition, anthropometrics and the level of habitual physical activity two weeks prior to and six months after bariatric surgery...
March 15, 2018: Clinics
https://www.readbyqxmd.com/read/29560073/nasal-cannula-apneic-oxygenation-prevents-desaturation-during-endotracheal-intubation-an-integrative-literature-review
#18
REVIEW
Joshua M Gleason, Bill R Christian, Erik D Barton
Patients requiring emergency airway management may be at greater risk of acute hypoxemic events because of underlying lung pathology, high metabolic demands, insufficient respiratory drive, obesity, or the inability to protect their airway against aspiration. Emergency tracheal intubation is often required before complete information needed to assess the risk of procedural hypoxia is acquired (i.e., arterial blood gas level, hemoglobin value, or chest radiograph). During pre-oxygenation, administering high-flow nasal oxygen in addition to a non-rebreather face mask can significantly boost the effective inspired oxygen...
March 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29557605/the-impact-of-obesity-on-specific-airway-resistance-and-conductance-among-schoolchildren
#19
Andrea Parraguez Arévalo, Francisco Rojas Navarro, Macarena Ruz Céspedes, Paul Medina González, Máximo Escobar Cabello, Rodrigo Muñoz Cofré
INTRODUCTION: Child and adolescent obesity is an epidemiological problem in developing countries. Its prevalence among preschoolers and schoolchildren is over 30%. It has been associated with a wide range of health complications, including rapid loss of lung function leading to changes in physiology and ventilatory mechanics. The objective of this study was to analyze the association between obesity and the increase in specific airway resistance (sRaw) in a sample of obese children and adolescents from the district of Talca...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29555862/cancer-incidence-and-survival-among-m%C3%A3-tis-adults-in-canada-results-from-the-canadian-census-follow-up-cohort-1992-2009
#20
Maegan V Mazereeuw, Diana R Withrow, E Diane Nishri, Michael Tjepkema, Eduardo Vides, Loraine D Marrett
BACKGROUND: Métis people are 1 of 3 Aboriginal groups recognized by the Canadian constitution. We estimated site-specific incidence rates and survival for the most common cancers among Métis adults in Canada and compared these with rates among non-Aboriginal adults in Canada. METHODS: We examined responses to the 1991 long-form census, including self-reported Métis ancestry linked to national mortality and cancer databases for followup from 1992 to 2009. We estimated age-standardized incidence rates and 5-year relative survival...
March 19, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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