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https://www.readbyqxmd.com/read/28430689/perioperative-outcomes-of-robotic-assisted-hysterectomy-compared-with-open-hysterectomy
#1
Bhargavi Gali, Jamie N Bakkum-Gamez, David J Plevak, Darrell Schroeder, Timothy O Wilson, Christopher J Jankowski
BACKGROUND: Increasing numbers of robotic hysterectomies (RH) are being performed. To provide ventilation (with pneumoperitoneum and steep Trendelenburg position) for these procedures, utilization of lung protective strategies with limiting airway pressures and tidal volumes is difficult. Little is known about the effects of intraoperative mechanical ventilation and high peak airway pressures on perioperative complications. We performed a retrospective review to determine whether patients undergoing RH had increased pulmonary complications compared to total abdominal hysterectomy (TAH)...
April 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28430296/effect-of-body-mass-index-on-the-outcome-of-surgical-patients-receiving-extracorporeal-devices-vv-ecmo-pecla-for-respiratory-failure
#2
Justyna Swol, Dirk Buchwald, Justus T Strauch, Thomas A Schildhauer, Christopher Ull
INTRODUCTION: To determine whether obese surgical patients are at a significant disadvantage in terms of outcomes after extracorporeal device (ECD) support, such as veno-venous extracorporeal membrane oxygenation (VV ECMO) or pumpless extracorporeal lung assist (pECLA), for respiratory failure, the relationship between body mass index (BMI) and hospital outcomes was analyzed. METHODS: This retrospective study included data on patients who were supported with an ECD between January 1, 2008 and December 31, 2014...
April 20, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28426531/high-fat-feeding-protects-mice-from-ventilator-induced-lung-injury-via-neutrophil-independent-mechanisms
#3
Michael R Wilson, Joanne E Petrie, Michael W Shaw, Cong Hu, Charlotte M Oakley, Samantha J Woods, Brijesh V Patel, Kieran P O'Dea, Masao Takata
OBJECTIVE: Obesity has a complex impact on acute respiratory distress syndrome patients, being associated with increased likelihood of developing the syndrome but reduced likelihood of dying. We propose that such observations are potentially explained by a model in which obesity influences the iatrogenic injury that occurs subsequent to intensive care admission. This study therefore investigated whether fat feeding protected mice from ventilator-induced lung injury. DESIGN: In vivo study...
April 19, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28424066/short-term-exposure-to-pm2-5-and-vanadium-and-changes-in-asthma-gene-dna-methylation-and-lung-function-decrements-among-urban-children
#4
Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R Jezioro, Lori Hoepner, Jamie Ross, Frederica P Perera, Steven N Chillrud, Rachel L Miller
BACKGROUND: Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μm (PM2.5) and vanadium (V) would be associated with altered buccal cell DNA methylation of targeted asthma genes and decreased lung function among urban children in a nested subcohort of African American and Dominican children. METHODS: Six day integrated levels of air pollutants were measured from children's homes (age 9-14; n = 163), repeated 6 months later (n = 98)...
April 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28420371/effect-of-pulmonary-arteriovenous-malformations-on-the-mechanical-properties-of-the-lungs
#5
Cécile Rotenberg, Marcel Bonay, Mostafa El Hajjam, Sandra Blivet, Alain Beauchet, Pascal Lacombe, Thierry Chinet
BACKGROUND: Pulmonary arteriovenous malformations (PAVMs) are present in approximately 15-50% individuals with hereditary hemorrhagic telangiectasia (HHT). They may be isolated but more often are multiple. The goal of this study was to evaluate the influence of PAVMs on lung mechanical properties. METHODS: We reviewed the files of all adult patients (age ≥ 18 years) referred to our Center for evaluation of HHT between 2005 and 2013. The diagnosis of HHT was based on the Curacao criteria and/or the presence of a pathogenic mutation...
April 19, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28420250/the-european-association-of-preventive-cardiology-exercise-prescription-in-everyday-practice-and-rehabilitative-training-expert-tool-a-digital-training-and-decision-support-system-for-optimized-exercise-prescription-in-cardiovascular-disease-concept-definitions
#6
Dominique Hansen, Paul Dendale, Karin Coninx, Luc Vanhees, Massimo F Piepoli, Josef Niebauer, Veronique Cornelissen, Roberto Pedretti, Eva Geurts, Gustavo R Ruiz, Ugo Corrà, Jean-Paul Schmid, Eugenio Greco, Constantinos H Davos, Frank Edelmann, Ana Abreu, Bernhard Rauch, Marco Ambrosetti, Simona S Braga, Olga Barna, Paul Beckers, Maurizio Bussotti, Robert Fagard, Pompilio Faggiano, Esteban Garcia-Porrero, Evangelia Kouidi, Michel Lamotte, Daniel Neunhäuserer, Rona Reibis, Martijn A Spruit, Christoph Stettler, Tim Takken, Cajsa Tonoli, Carlo Vigorito, Heinz Völler, Patrick Doherty
Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same patient. It was aimed to develop a digital training and decision support system for exercise prescription in cardiovascular disease patients in clinical practice: the European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28415779/relationship-of-p73-gene-polymorphism-and-additional-gene-smoking-and-gene-obesity-interaction-with-non-small-cell-lung-cancer-risk
#7
Qiuge Wu, Yan Shi, Lulu Ge, Dongbo Ma, Hui Zhang, Jing Wang
AIM: The aim of this study was to investigate the impact of G4C14-to-A4T14 polymorphism within P73 gene and additional interactions with current smoking and obesity on non-small cell lung cancer (NSCLC) risk in a Chinese population. RESULTS: Logistic regression analysis showed a significant association between genotypes of the AT allele in G4C14-to-A4T14 and decreased NSCLC risk. NSCLC risk was significantly lower in carriers of the G4C14-to-A4T14- AT allele than those with GC/GC genotype (AT/AT + GC/AT versus GC/GC), adjusted OR (95%CI) = 0...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411906/serum-levels-of-adiponectin-and-leptin-in-asthmatic-patients-and-its-relation-with-asthma-severity-lung-function-and-bmi
#8
R Nasiri Kalmarzi, P Ataee, M Mansori, G Moradi, S Ahmadi, Z Kaviani, B Khalafi, W Kooti
INTRODUCTION: Asthma is one of the diseases which has a high prevalence in developed and developing countries. The relationship between asthma and obesity has always been focused by researchers. In this field, adipokines, especially adiponectin and leptin have highly attended by the scientist. The aim of this study was to determine the serum level of adiponectin, leptin and the leptin/adiponectin ratio in asthmatic patients and its relationship with disease severity, lung function and BMI (body mass index)...
May 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28408935/socioeconomic-and-racial-ethnic-disparities-in-cancer-mortality-incidence-and-survival-in-the-united-states-1950-2014-over-six-decades-of-changing-patterns-and-widening-inequalities
#9
Gopal K Singh, Ahmedin Jemal
We analyzed socioeconomic and racial/ethnic disparities in US mortality, incidence, and survival rates from all-cancers combined and major cancers from 1950 to 2014. Census-based deprivation indices were linked to national mortality and cancer data for area-based socioeconomic patterns in mortality, incidence, and survival. The National Longitudinal Mortality Study was used to analyze individual-level socioeconomic and racial/ethnic patterns in mortality. Rates, risk-ratios, least squares, log-linear, and Cox regression were used to examine trends and differentials...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28405036/rapidity-and-efficacy-of-ultrasonographic-sliding-lung-sign-and-auscultation-in-confirming-endotracheal-intubation-in-overweight-and-obese-patients
#10
Sunil Rajan, Jayasankar Surendran, Jerry Paul, Lakshmi Kumar
BACKGROUND AND AIMS: Obese individuals are predisposed to difficult airway and intubation. They usually yield confusing or misleading auscultatory findings. We aimed to assess the rapidity and efficacy of ultrasonographic (USG) sliding lung sign for confirming endotracheal intubation in normal as well as overweight and obese surgical patients. METHODS: This prospective, observational study was performed in forty surgical patients. Twenty patients with body mass index (BMI) <25 were recruited to Group A, whereas twenty patients with BMI ≥25 constituted Group B...
March 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28403098/the-effects-of-body-mass-index-on-spirometry-tests-among-adults-in-xi-an-china
#11
Shengyu Wang, Xiuzhen Sun, Te-Chun Hsia, Xiaobo Lin, Manxiang Li
Obese people have higher risk of respiratory symptoms. The relationship between obesity and lung function varies with age, race, and geographical region. The objective of this study is to examine the effects of body mass index on spirometric tests among adults in Xi'an city.This is a cross-sectional study. Pulmonary function testing was conducted on participants recruited from Xi'an, China between July and August 2012. Force expiratory volume in first second (FEV1), force vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF25-75) were measured by portable Spirometer...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28400405/nutritional-approaches-for-managing-obesity-associated-metabolic-diseases
#12
Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li, Chaodong Wu
Obesity is an ongoing pandemic and serves as a causal factor of a wide spectrum of metabolic diseases including diabetes, fatty liver disease, and cardiovascular disease. Much evidence has demonstrated that nutrient overload initiates or exacerbates inflammatory responses in tissues/organs involved in the regulation of systemic metabolic homeostasis. This obesity-associated inflammation is usually at a low-grade and viewed as metabolic inflammation. When it exists continuously, inflammation inappropriately alters metabolic pathways and impairs insulin signaling cascades in peripheral tissues/organs such as adipose tissue, the liver and skeletal muscle, resulting in local fat deposition and insulin resistance and systemic metabolic dysregulation...
April 11, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28397961/the-association-between-wedging-of-the-aorta-and-cardiac-structural-anatomy-as-revealed-using-multidetector-row-computed-tomography
#13
Shumpei Mori, Robert H Anderson, Tomofumi Takaya, Takayoshi Toba, Tatsuro Ito, Sei Fujiwara, Yoshiaki Watanabe, Tatsuya Nishii, Atsushi K Kono, Ken-Ichi Hirata
The aortic root is wedged within the cardiac base. The precise extent of aortic wedging, however, and its influence on the surrounding cardiac structures, has not been systematically investigated. We analysed 100 consecutive patients, who underwent coronary arterial computed tomographic angiography. We assessed the extent of aortic wedging by measuring the vertical distance between the non-adjacent aortic sinus and the inferior epicardium. A shorter distance indicates deeper aortic wedging. We assessed the tilt angle and diameter of the ascending aorta, the relative heights of the left atrial roof and the oval fossa, the shape of the proximal right coronary artery, the angle of the aorta relative to the left ventricular axis, and the lung volume...
April 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28397284/altered-fatty-acid-metabolism-and-reduced-stearoyl-coenzyme-a-desaturase-activity-in-asthma
#14
N Rodriguez-Perez, E Schiavi, R Frei, R Ferstl, P Wawrzyniak, S Smolinska, M Sokolowska, N A Sievi, M Kohler, P Schmid-Grendelmeier, D Michalovich, K D Simpson, E M Hessel, M Jutel, M Martin-Fontecha, O Palomares, C A Akdis, L O'Mahony
BACKGROUND: Fatty acids and lipid mediator signaling play an important role in the pathogenesis of asthma, yet this area remains largely under-explored. The aims of this study were (i) to examine fatty acid levels and their metabolism in obese and non-obese asthma patients and (ii) to determine the functional effects of altered fatty acid metabolism in experimental models. METHODS: Medium- and long-chain fatty acid levels were quantified in serum from 161 human volunteers by LC/MS...
April 11, 2017: Allergy
https://www.readbyqxmd.com/read/28389304/cluster-analysis-on-longitudinal-data-of-patients-with-adult-onset-asthma
#15
Pinja Ilmarinen, Leena E Tuomisto, Onni Niemelä, Minna Tommola, Jussi Haanpää, Hannu Kankaanranta
BACKGROUND: Previous cluster analyses on asthma are based on cross-sectional data. OBJECTIVE: To identify phenotypes of adult-onset asthma by using data from baseline (diagnostic) and 12-year follow-up visits. METHODS: The Seinäjoki Adult Asthma Study is a 12-year follow-up study of patients with new-onset adult asthma. K-means cluster analysis was performed by using variables from baseline and follow-up visits on 171 patients to identify phenotypes...
April 4, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28386756/effects-of-a-physical-activity-program-on-cardiorespiratory-fitness-and-pulmonary-function-in-obese-women-after-bariatric-surgery-a-pilot-study
#16
Tatiana Onofre, Renata Carlos, Nicole Oliver, Amanda Felismino, Davi Fialho, Renata Corte, Eliane Pereira da Silva, Eudes Godoy, Selma Bruno
BACKGROUND: In severely obese individuals, reducing body weight induced by bariatric surgery is able to promote a reduction in comorbidities and improve respiratory symptoms. However, cardiorespiratory fitness (CRF) reflected by peak oxygen uptake (VO2peak) may not improve in individuals who remain sedentary post-surgery. The objective of this study was to evaluate the effects of a physical training program on CRF and pulmonary function in obese women after bariatric surgery, and to compare them to a control group...
April 7, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28380304/cardiopulmonary-exercise-testing-in-heart-failure-patients-with-specific-comorbidities
#17
Massimo F Piepoli, Ugo Corrà, Piergiuseppe Agostoni
Exercise capacity is one of the most powerful predicting factors of life expectancy, both in patients with and without cardiac disease. Cardiopulmonary exercise testing provides a global assessment of the integrative exercise responses involving the pulmonary, cardiovascular, hematopoietic, neuropsychological, and skeletal muscle systems, which are not adequately reflected through the measurement of individual organ system function. This relatively noninvasive, dynamic, physiologic overview allows the evaluation of both submaximal and peak exercise responses, providing the physician with relevant information for clinical decision making...
April 5, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28376206/prediagnostic-body-mass-index-trajectories-in-relation-to-prostate-cancer-incidence-and-mortality-in-the-plco-cancer-screening-trial
#18
Scott P Kelly, Barry I Graubard, Gabriella Andreotti, Naji Younes, Sean D Cleary, Michael B Cook
Background: Evidence suggests that obesity in adulthood is associated with increased risk of "clinically significant" prostate cancer. However, studies of body mass index (BMI) across the adult life course and prostate cancer risks remain limited. Methods: In a prospective cohort of 69 873 men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined associations of prediagnostic BMI across the adult life course with risk of incident prostate cancer and fatal prostate cancer (prostate cancer-specific mortality)...
March 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376119/obesity-disproportionately-impacts-lung-volumes-airflow-and-exhaled-nitric-oxide-in-children
#19
Tsung-Chieh Yao, Hui-Ju Tsai, Su-Wei Chang, Ren-Hua Chung, Jing-Ya Hsu, Ming-Han Tsai, Sui-Ling Liao, Man-Chin Hua, Shen-Hao Lai, Li-Chen Chen, Kuo-Wei Yeh, Yu-Lun Tseng, Wan-Chen Lin, Su-Ching Chang, Jing-Long Huang
BACKGROUND: The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with lung function and FeNO in children is modified by atopy is unclear. The objective of this study was to examine the effect of excess weight on lung function parameters and FeNO among Asian children, with a particular focus on exploring the potential effect modification by atopy...
2017: PloS One
https://www.readbyqxmd.com/read/28366262/managing-a-patient-with-copd
#20
Isabelle Clavagnier
Mrs. Hayek, a patient so obese as to be house-bound, is admitted to the Medical Unit with exacerbation of her COPD (Chronic obstructive pulmonary disease) and lung infection. After her discharge from hospital, the district nursing service draws up a care plan with her.
April 2017: Revue de L'infirmière
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