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https://www.readbyqxmd.com/read/29881817/metastasis-associated-lung-adenocarcinoma-transcript-1-as-a-common-molecular-driver-in-the-pathogenesis-of-nonalcoholic-steatohepatitis-and-chronic-immune-mediated-liver-damage
#1
Silvia Sookoian, Diego Flichman, Martin E Garaycoechea, Julio San Martino, Gustavo O Castaño, Carlos J Pirola
Long noncoding RNAs (lncRNAs) are functional molecules that orchestrate gene expression. To identify lncRNAs involved in nonalcoholic fatty liver disease (NAFLD) severity, we performed a multiscale study that included: (a) systems biology modeling that indicated metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) as a candidate lncRNA for exploring disease-related associations, (b) translational exploration in the clinical setting, and (c) mechanistic modeling. MALAT1 liver profiling was performed in three consecutive phases, including an exploratory stage (liver samples from patients with NAFLD who were morbidly obese [n = 47] and from 13 individuals with normal liver histology); a replication stage (patients with NAFLD and metabolic syndrome [n =49]); and a hypothesis-driven stage (patients with chronic hepatitis C and autoimmune liver diseases, [n = 65])...
June 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29881704/is-obesity-related-to-the-lung-function-of-non-asthmatic-children
#2
REVIEW
Andrew Fretzayas, Maria Moustaki, Ioanna Loukou, Konstantinos Douros
Overweight and obesity are highly prevalent in developed and developing countries among children and adolescents. During the last two decades, it became evident that excess weight is adversely related to respiratory health in childhood and adolescence mainly in terms of asthma occurrence. Additionally, there is a mounting body of evidence that overweight/obesity may also affect lung function in non-asthmatic subjects. The aim of this review was to present and discuss the studies that investigated this issue in non-asthmatic children and adolescents...
May 8, 2018: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/29873189/prevalence-and-features-of-asthma-copd-overlap-in-the-u-s-2007-2012
#3
Angelico Mendy, Erick Forno, Theophile Niyonsenga, Ryan Carnahan, Janvier Gasana
BACKGROUND: Perceived to be distinct, asthma and chronic obstructive pulmonary disease (COPD) can co-exist and potentially have a worse prognosis than the separate diseases. Yet, little is known about the exact prevalence and the characteristics of the Asthma-COPD overlap (ACO) in the U.S. POPULATION: <AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To determine ACO prevalence in the U.S., identify ACO predictors, examine ACO association with asthma and COPD severity, and describe distinctive spirometry and laboratory features of ACO...
June 5, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29858003/asthma-and-its-comorbidities-in-middle-aged-and-older-adults-the-rotterdam-study
#4
Emmely W de Roos, Lies Lahousse, Katia M C Verhamme, Gert-Jan Braunstahl, M Arfan Ikram, Johannes C C M In 't Veen, Bruno H Ch Stricker, Guy G O Brusselle
BACKGROUND: Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over. METHODS: We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands...
June 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29844667/distribution-and-characteristics-of-copd-phenotypes-results-from-the-polish-sub-cohort-of-the-pope-study
#5
Aleksander Kania, Rafał Krenke, Krzysztof Kuziemski, Małgorzata Czajkowska-Malinowska, Natalia Celejewska-Wójcik, Barbara Kuźnar-Kamińska, Małgorzata Farnik, Juliusz Bokiej, Marta Miszczuk, Iwona Damps-Konstańska, Marcin Grabicki, Marzena Trzaska-Sobczak, Krzysztof Sładek, Halina Batura-Gabryel, Adam Barczyk
Background: This study aimed to examine the distribution of predefined phenotypes, demographic data, clinical outcomes, and treatment of patients who were included in the Polish cohort of the Phenotypes of COPD in Central and Eastern Europe (POPE) study. Patients and methods: This was a sub-analysis of the data from the Polish cohort of the POPE study, an international, multicenter, observational cross-sectional survey of COPD patients in Central and Eastern European countries...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29842885/m-6-a-demethylase-fto-facilitates-tumor-progression-in-lung-squamous-cell-carcinoma-by-regulating-mzf1-expression
#6
Jiqin Liu, Dangli Ren, Zhenhua Du, Hekong Wang, Hua Zhang, Ying Jin
N6 -Methyladenosine (m6 A) represents the most prevalent internal modification in mammalian mRNAs. Emerging evidences suggest that m6 A modification is profoundly implicated in many biological processes, including cancer development. However, limited knowledge is available about the functional importance of m6 A in lung cancer. In this study, by data mining The Cancer Genome Atlas (TCGA) database, we first identified fat mass- and obesity-associated protein (FTO) as a prognostic factor for lung squamous cell carcinoma (LUSC)...
May 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29809185/-effect-of-the-components-of-the-metabolic-syndrome-on-pulmonary-function-the-unexpected-role-of-high-density-lipoprotein-cholesterol
#7
Saúl Huerta-Ramírez, Angélica Paniagua-Pérez, David Castro-Serna, Andrés Ledesma-Velázquez, Alberto Rubio-Guerra, Germán Vargas-Ayala
Background: Metabolic syndrome is a condition that predisposes to cardiovascular disease and diabetes mellitus. In addition, it can have effects over neoplastic pathologies, liver and pulmonary function. Our objective is to analyze the effect of the metabolic syndrome and its components on pulmonary function. Method: 110 subjects from Mexico City were evaluated and anthropometric measurements, glucose determination, triglycerides and high-density lipoprotein (HDL) cholesterol were made...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29771333/multiple-comorbid-conditions-sleep-quality-and-duration-and-academic-performance-in-urban-children-with-asthma
#8
Katharine C Reynolds, Julie Boergers, Sheryl J Kopel, Daphne Koinis-Mitchell
Objective: Common comorbid medical conditions including allergic rhinitis (AR), obesity, and sleep disordered breathing (SDB) have been linked with asthma exacerbations; however, these conditions also impact sleep and academic functioning. The current study sought to examine unique and combined associations of these common comorbidities on sleep and academic performance among urban minority children with persistent asthma. We expected additional comorbid diagnoses would be associated with poorer sleep and academic functioning...
May 15, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29755730/having-concomitant-asthma-phenotypes-is-common-and-independently-relates-to-poor-lung-function-in-nhanes-2007-2012
#9
Rita Amaral, João A Fonseca, Tiago Jacinto, Ana M Pereira, Andrei Malinovschi, Christer Janson, Kjell Alving
Background: Evidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Methods: Data from the National Health and Nutrition Examination Surveys (NHANES) 2007-2012 were used (n = 30,442). Adults with current asthma were selected...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29751547/the-relationship-between-diabetes-mellitus-and-respiratory-function-in-patients-eligible-for-coronary-artery-bypass-grafting
#10
Aleksandra Szylińska, Mariusz Listewnik, Żaneta Ciosek, Magdalena Ptak, Anna Mikołajczyk, Wioletta Pawlukowska, Iwona Rotter
Introduction: Spirometry performed prior to surgery provides information on the types of lung disorders in patients. The purpose of this study was to look for a relationship between the prevalence of diabetes and spirometry parameters. Material and Methods: The study was conducted in patients with coronary artery disease who were eligible for an isolated coronary artery bypass graft in 2013. The study group included 367 patients (287 men and 80 women) aged 68.7 ± 8.4 years. They were divided into those with diagnosed diabetes (group I, n = 138, 37...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29747667/protective-effect-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-dyshomeostasis-of-energetic-metabolism-in-rat-lung
#11
Mohamed El Ayed, Safwen Kadri, Maha Mabrouk, Ezzedine Aouani, Salem Elkahoui
BACKGROUND: Obesity is currently one of the major epidemics of this millennium and affects poeples throughout the world. It causes multiple systemic complications as it significantly interferes with respiratory function. OBJECTIVE: We aimed in the present work to study the effect of high fat diet (HFD) on lung oxidative stress and energy metabolism alterations, as well as the putative protection afforded by grape seed and skin extract (GSSE). METHODS: We started by characterizing the GSSE and its composition using gas chromatography coupled to mass spectrometry (GC-MS)...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29729164/cluster-analysis-of-the-phenotype-of-asthma-and-obesity
#12
Victoria S Sukhan
OBJECTIVE: Introduction: The combination of asthma and obesity can affect the mutual encumbrance to which other pathogenetic mechanisms join, which worsen the course of both diseases. The aim of the work is to analyze the features of the genotype and phenotype in patients with a combined course of asthma and obesity. PATIENTS AND METHODS: Materials and methods: In order to detect the features of obesity asthma, 108 patients were examined. Patients were divided into two groups: the first included 50 patients with normal body weight, the second - 58 patients with obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29720598/relationship-between-body-mass-index-and-renal-function-deterioration-among-the-taiwanese-chronic-kidney-disease-population
#13
Tian-Jong Chang, Cai-Mei Zheng, Mei-Yi Wu, Tzu-Ting Chen, Yun-Chun Wu, Yi-Lien Wu, Hsin-Ting Lin, Jing-Quan Zheng, Nain-Feng Chu, Yu-Me Lin, Sui-Lung Su, Kuo-Cheng Lu, Jin-Shuen Chen, Fung-Chang Sung, Chien-Te Lee, Yu Yang, Shang-Jyh Hwang, Ming-Cheng Wang, Yung-Ho Hsu, Hung-Yi Chiou, Senyeong Kao, Yuh-Feng Lin
This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29684318/does-size-matter-when-calculating-the-correct-tidal-volume-for-pediatric-mechanical-ventilation-a-hypothesis-based-on-fvc
#14
Gina J Kim, Christopher J L Newth, Robinder G Khemani, Suzy L Wong, Allan L Coates, Patrick A Ross
BACKGROUND: Tidal volumes standardized to predicted body weight are recommended for adult mechanical ventilation, but children are frequently ventilated by using measured body weight. The goal of this study was to examine the difference in FVC (in milliliters per kilogram [mL/kg]) by using measured body weight compared with predicted body weight in children. METHODS: This retrospective analysis included outpatient pulmonary function tests (PFTs) from two datasets...
April 22, 2018: Chest
https://www.readbyqxmd.com/read/29671629/impaired-left-ventricular-filling-is-associated-with-decreased-pulse-oximetry-values
#15
Lene Gjelseth Dalbak, Henrik Schirmer, Jørund Straand, Ibrahimu Mdala, Ole Geir Solberg, Hasse Melbye
OBJECTIVES: The aim of this study was to investigate the association between echocardiographic measures of diastolic left ventricular dysfunction and decreased arterial oxyhaemoglobin saturation measured with pulse oximetry (SpO2 ). DESIGN: This is a cross-sectional population-based survey of Norwegian adults. Values obtained using echocardiography, pulse oximetry, and spirometry were included. The primary outcome was abnormal mitral Doppler inflow, defined as normal: E/A ratio 0...
April 19, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29663179/the-impact-of-obesity-on-pulmonary-deterioration-in-patients-undergoing-robotic-assisted-laparoscopic-prostatectomy
#16
Sebastian Blecha, Marion Harth, Florian Zeman, Timo Seyfried, Matthias Lubnow, Maximilian Burger, Stefan Denzinger, Michael T Pawlik
Obesity affects respiratory and hemodynamic function in anesthetized patients. The aim of this study was to evaluate the influence of the body mass index (BMI) on pulmonary changes in a permanent 45° steep Trendelenburg position (STP) during robotic-assisted laparoscopic prostatectomy (RALP). 51 patients undergoing RALP under standardized anesthesia were included. Perioperative pulmonary function and oxygenation were measured in awake patients (T0 ), 20 min after the induction of anesthesia (T1 ), after insufflation of the abdomen in supine position (T2 ), after 30 min in STP (T3 ), when controlling Santorini's plexus in STP (T4 ), before awakening while supine (T5 ), and after 45 min in the recovery room (T6 )...
April 16, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29627041/obesity-and-asthma
#17
REVIEW
Ubong Peters, Anne E Dixon, Erick Forno
Obesity is a vast public health problem and both a major risk factor and disease modifier for asthma in children and adults. Obese subjects have increased asthma risk, and obese asthmatic patients have more symptoms, more frequent and severe exacerbations, reduced response to several asthma medications, and decreased quality of life. Obese asthma is a complex syndrome, including different phenotypes of disease that are just beginning to be understood. We examine the epidemiology and characteristics of this syndrome in children and adults, as well as the changes in lung function seen in each age group...
April 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29608145/intraperitoneal-glucose-tolerance-test-measurement-of-lung-function-and-fixation-of-the-lung-to-study-the-impact-of-obesity-and-impaired-metabolism-on-pulmonary-outcomes
#18
Katharina Dinger, Jasmine Mohr, Christina Vohlen, Dharmesh Hirani, Eva Hucklenbruch-Rother, Regina Ensenauer, Jörg Dötsch, Miguel A Alejandre Alcazar
Obesity and respiratory disorders are major health problems. Obesity is becoming an emerging epidemic with an expected number of over 1 billion obese individuals worldwide by 2030, thus representing a growing socioeconomic burden. Simultaneously, obesity-related comorbidities, including diabetes as well as heart and chronic lung diseases, are continuously on the rise. Although obesity has been associated with increased risk for asthma exacerbations, worsening of respiratory symptoms, and poor control, the functional role of obesity and perturbed metabolism in the pathogenesis of chronic lung disease is often underestimated, and underlying molecular mechanisms remain elusive...
March 15, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29605211/spirometric-impairments-cardiovascular-outcomes-and-noncardiovascular-death-in-older-persons
#19
Carlos A Vaz Fragoso, Peter H Van Ness, Terrence E Murphy, Gail J McAvay
BACKGROUND: In prior work involving older persons, the reported associations of spirometric impairments with cardiovascular outcomes may have been confounded by age-related changes in lung function. Hence, using more age-appropriate spirometric criteria from the Global Lung Function Initiative (GLI), we have evaluated the associations of spirometric impairments, specifically restrictive-pattern and airflow-obstruction, with cardiovascular death (CV-death) and hospitalization (CV-hospitalization)...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29589109/prevalence-and-associated-factors-of-preoperative-functional-disability-in-elective-surgical-patients-over-55-years-old-a-prospective-cohort-study
#20
Mitsuru Ida, Yusuke Naito, Yasunori Matsunari, Yuu Tanaka, Satoki Inoue, Masahiko Kawaguchi
PURPOSE: In preoperative settings, patients may have functional disabilities due to the disease for which surgery is being performed or comorbidities, but the associated and predictive factors remain unknown. This study examined the prevalence of preoperative functional disability and clarified the associated factors. METHODS: Individuals aged ≥ 55 years who were scheduled to undergo surgery in a tertiary-care hospital in Japan between April 2016 and September 2016 were eligible for enrolment in the study...
March 27, 2018: Journal of Anesthesia
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