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obesity lung function

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https://www.readbyqxmd.com/read/28967546/overweight-obesity-and-lung-function-in-children-and-adults-a-meta-analysis
#1
Erick Forno, Yueh-Ying Han, James Mullen, Juan C Celedón
BACKGROUND: There is conflicting evidence on the effect of obesity on lung function in adults and children with and without asthma. We aimed to evaluate the relation between overweight or obesity and lung function, and whether such relationship varies by age, sex, or asthma status. METHODS: We searched PubMed, Scopus, CINAHL, Cochrane, and EMBASE for all studies (in English) reporting on obesity status (by body mass index) and lung function, from 2005 to 2017. Main outcomes were forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow between 25th and 75th percentile of the forced vital capacity (FEF25-75), total lung capacity (TLC), residual volume (RV), and functional residual capacity (FRC)...
September 26, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28963087/metformin-influences-on-respiratory-system-in-obese-mice-induced-by-postnatal-overnutrition
#2
Maycon Daniel Dias, Melissa Goulart, Cecilia Dalécio, Silvia Enes-Marques, Évila da Silva Lopes Salles, Marina Venâncio, Elisângela Monteiro Pereira, Valdemar Antonio Paffaro, Erika Kristina Incerpi, Roseli Soncini
Many studies have confirmed the merits of metformin to treat type 2 diabetes, but few studies have addressed its effect on the respiratory system. Moreover, vascular endothelial growth factor (VEGF) is critical to many lung functions. In this way, we evaluated the metformin impact on the lung in treated obese Swiss mice, induced by postnatal overnutrition. Glucose and insulin were detected and the insulin resistance index (HOMA) was calculated; inflammatory cells and nitrite/nitrate concentration (NOx) was quantified from bronchoalveolar lavage, collagen and lung VEGF-a was analysed in the lung tissue and lung mechanics were evaluated by methacholine-induced bronchoconstriction...
September 28, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28952460/serum-and-exhaled-breath-condensate-leptin-levels-in-asthmatic-and-obesity-children-a-pilot-study
#3
A Bodini, L Tenero, M Sandri, C Maffeis, M Piazza, L Zanoni, D Peroni, A Boner, G Piacentini
BACKGROUND: Recent studies have highlighted the possible involvement of leptin in inflammation. The leptin receptor is also expressed by alveolar macrophages, T lymphocytes and bronchial epitelial cells, suggesting a possible role in the cascade of airway inflammation. OBJECTIVES: The aim of the study was to evaluate the levels of leptin in exhaled breath condensate (EBC) from asthmatic, normal- and overweight children, in relationship with airway inflammation. METHODS: 15 asthmatic non-obese children, 15 healthy non-asthmatic non-obese children, 11 obese children with asthma (OA) and 20 obese children without asthma (ONA) were enrolled...
September 27, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28951839/lower-cellular-metabolic-power-can-be-an-explanation-for-obesity-trend-in-tae-eum-type-hypothesis-and-clinical-observation
#4
Eun Bo Shim, Chae Hun Leem, Joong Jae Kim, Jong Yeol Kim
BACKGROUND: Those classified as Tae-Eum (TE)-type people in Sasang constitutional medicine (SCM) are prone to obesity. Although extensive clinical observations have confirmed this tendency, the underlying physiological mechanisms are unknown. Here, we propose a novel hypothesis using integrative physiology to explain this phenomenon. METHODS: Hypoactive lung function in the TE type indicates that respiration is attenuated at the cellular level-specifically, mitochondrial oxygen consumption...
September 2017: Integrative medicine research
https://www.readbyqxmd.com/read/28947030/the-association-between-anthropometric-measures-and-lung-function-in-a-population-based-study-of-canadian-adults
#5
A Rowe, P Hernandez, S Kuhle, S Kirkland
BACKGROUND: Decreased lung function has health impacts beyond diagnosable lung disease. It is therefore important to understand the factors that may influence even small changes in lung function including obesity, physical fitness and physical activity. The aim of this study was to determine the anthropometric measure most useful in examining the association with lung function and to determine how physical activity and physical fitness influence this association. METHODS: The current study used cross-sectional data on 4662 adults aged 40-79 years from the Canadian Health Measures Survey Cycles 1 and 2...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28945872/serum-surfactant-protein-d-as-a-biomarker-for-measuring-lung-involvement-in-obese-type-2-diabetic-patients
#6
Carolina López-Cano, Albert Lecube, Marta García-Ramírez, Xavier Muñoz, Enric Sánchez, Asunción Seminario, Marta Hernández, Andreea Ciudin, Liliana Gutiérrez, Cristina Hernández, Rafael Simó
Context: Lung impairment is a new target for late diabetic complications. Biomarkers that could facilitate the identification of patients requiring functional respiratory tests have not been reported. Objective: The aim of this study is to examine whether serum surfactant protein D (SP-D) and A (SP-A) could be useful biomarkers of lung damage in obese patients with type 2 diabetes without known lung disease. Design and Setting: A case-control study conducted in an ambulatory obesity unit...
September 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28931052/improvement-of-dyspnea-after-bariatric-surgery-is-associated-with-increased-expiratory-reserve-volume-a-prospective-follow-up-study-of-45-patients
#7
Louis Boissière, Jeanne-Marie Perotin-Collard, Eric Bertin, Isabelle Gaubil, Ana Diaz Cives, Coralie Barbe, Sandra Dury, Julie Nardi, François Lebargy, Gaëtan Deslée, Claire Launois
OBJECTIVES: To assess the effects of bariatric surgery in patients with obesity on dyspnea and to analyze the relationships between improvement of dyspnea after bariatric surgery and changes in pulmonary function, especially Expiratory Reserve Volume (ERV) which is the lung volume abnormality most frequently associated with obesity. METHODS: Forty-five patients (5 males/40 females, mean Body Mass Index = 46.2 ± 6.8 kg/m2) were evaluated before and 6 to 12 months after bariatric surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28928207/a-perfect-storm-increased-colonization-and-failure-of-vaccination-leads-to-severe-secondary-bacterial-infection-in-influenza-virus-infected-obese-mice
#8
Erik A Karlsson, Victoria A Meliopoulos, Nicholas C van de Velde, Lee-Ann van de Velde, Beth Mann, Geli Gao, Jason Rosch, Elaine Tuomanen, Jon McCullers, Peter Vogel, Stacey Schultz-Cherry
Obesity is a risk factor for developing severe disease following influenza virus infection; however, the comorbidity of obesity and secondary bacterial infection, a serious complication of influenza virus infections, is unknown. To fill this gap in knowledge, lean and obese C57BL/6 mice were infected with a nonlethal dose of influenza virus followed by a nonlethal dose of Streptococcus pneumoniae Strikingly, not only did significantly enhanced death occur in obese coinfected mice compared to lean controls, but also high mortality was seen irrespective of influenza virus strain, bacterial strain, or timing of coinfection...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28916790/association-between-homa-ir-and-lung-function-in-korean-young-adults-based-on-the-korea-national-health-and-nutrition-examination-survey
#9
Young Bok Lee, Young Soo Kim, Dong-Hee Lee, Hee Yeon Kim, Jae-Im Lee, Hyo-Suk Ahn, Tae Seo Sohn, Tae-Kyu Lee, Jae Yen Song, Chang Dong Yeo, Mihee Hong, Kyungdo Han, Seong Cheol Jeong, Hiun Suk Chae
Metabolic syndrome, including obesity and insulin resistance, has been reported to lower lung function in elderly subjects with asthma or chronic obstructive lung disease. This study aimed to find the association between lung function and insulin resistance in Korean young adults. This study used data from the Korean National Health and Nutrition Examination Survey 2011-2013, which is a representative sample of the Korean population. A total of 1,922 young adults aged 19 to 40 were included in the analysis...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28913987/clinical-characteristics-of-exacerbation-prone-adult-asthmatics-identified-by-cluster-analysis
#10
Mi Ae Kim, Seung Woo Shin, Jong Sook Park, Soo Taek Uh, Hun Soo Chang, Da Jeong Bae, You Sook Cho, Hae Sim Park, Ho Joo Yoon, Byoung Whui Choi, Yong Hoon Kim, Choon Sik Park
PURPOSE: Asthma is a heterogeneous disease characterized by various types of airway inflammation and obstruction. Therefore, it is classified into several subphenotypes, such as early-onset atopic, obese non-eosinophilic, benign, and eosinophilic asthma, using cluster analysis. A number of asthmatics frequently experience exacerbation over a long-term follow-up period, but the exacerbation-prone subphenotype has rarely been evaluated by cluster analysis. This prompted us to identify clusters reflecting asthma exacerbation...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28903915/obesity-modulates-diaphragm-curvature-in-subjects-with-and-without-copd
#11
Aladin M Boriek, Michael A Lopez, Cristina Velasco, Azam A Bakir, Anna Frolov, Shari Wynd, Tony G Babb, Nicola A Hanania, Eric A Hoffman, Amir Sharafkhaneh
BACKGROUND: Obesity is a common co-morbidity of COPD and has been associated with worse outcomes. However, it is unknown whether the interaction between obesity and COPD modulates diaphragm shape and consequently its function. The body mass index has been used as a correlate of obesity. We tested the hypothesis that the shape of the diaphragm muscle and size of the ring of its insertion in Non-COPD and COPD subjects are modulated by BMI. METHODS: We recruited 48 COPD patients with post-bronchiodilator FEV1/FVC < 0...
September 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28899934/bronchial-hyperresponsiveness-and-obesity-in-middle-age-insights-from-an-australian-cohort
#12
John A Burgess, Melanie C Matheson, Fei Diao, David P Johns, Bircan Erbas, Adrian J Lowe, Lyle C Gurrin, Caroline J Lodge, Paul S Thomas, Stephen Morrison, Bruce R Thompson, Iain Feather, Jennifer L Perret, Michael J Abramson, Graham G Giles, John L Hopper, Shyamali C Dharmage, Eugene H Walters
The association between obesity and bronchial hyperresponsiveness (BHR) is incompletely characterised. Using the 2006 follow-up of the Tasmanian Longitudinal Health Study, we measured the association between obesity and BHR and whether it was mediated by small airway closure or modified by asthma and sex of the patient.A methacholine challenge measured BHR. Multivariable logistic regression measured associations between body mass index (BMI) and BHR, adjusting for sex, asthma, smoking, corticosteroid use, family history and lung function...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28875324/-extreme-obesity-particular-aspect-of-invasive-and-noninvasive-ventilation
#13
REVIEW
M Deppe, P Lebiedz
The obesity rate is increasing worldwide and the percentage of obese patients in the intensive care unit (ICU) is rising concomitantly. Ventilatory support strategies in obese patients must take into account the altered pathophysiological conditions. Unfortunately, prospective randomized multicenter trials on this subject are lacking. Therefore, current strategies are based on the individual experiences of ICU physicians and single-center studies. Noninvasive ventilation (NIV) in critically ill patients with acute respiratory failure and obesity hypoventilation syndrome (OHS) is an efficient treatment option and should be provided as early as possible is an effort to avoid intubation...
September 5, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28866107/baseline-features-of-the-severe-asthma-research-program-sarp-iii-cohort-differences-with-age
#14
W Gerald Teague, Brenda R Phillips, John V Fahy, Sally E Wenzel, Anne M Fitzpatrick, Wendy C Moore, Annette T Hastie, Eugene R Bleecker, Deborah A Meyers, Stephen P Peters, Mario Castro, Andrea M Coverstone, Leonard B Bacharier, Ngoc P Ly, Michael C Peters, Loren C Denlinger, Sima Ramratnam, Ronald L Sorkness, Benjamin M Gaston, Serpil C Erzurum, Suzy A A Comhair, Ross E Myers, Joe Zein, Mark D DeBoer, Anne-Marie Irani, Elliot Israel, Bruce Levy, Juan Carlos Cardet, Wanda Phipatanakul, Jonathan M Gaffin, Fernando Holguin, Merritt L Fajt, Shean J Aujla, David T Mauger, Nizar N Jarjour
BACKGROUND: The effect of age on asthma severity is poorly understood. OBJECTIVES: The objective of this study was to compare the baseline features of severe and nonsevere asthma in the Severe Asthma Research Program (SARP) III cohort, and examine in cross section the effects of age on those features. METHODS: SARP III is a National Institutes of Health/National Heart Lung Blood Institute multisite 3-year cohort study conducted to investigate mechanisms of severe asthma...
August 30, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28860741/comparison-of-world-health-organization-and-asia-pacific-body-mass-index-classifications-in-copd-patients
#15
Jeong Uk Lim, Jae Ha Lee, Ju Sang Kim, Yong Il Hwang, Tae-Hyung Kim, Seong Yong Lim, Kwang Ha Yoo, Ki-Suck Jung, Young Kyoon Kim, Chin Kook Rhee
INTRODUCTION: A low body mass index (BMI) is associated with increased mortality and low health-related quality of life in patients with COPD. The Asia-Pacific classification of BMI has a lower cutoff for overweight and obese categories compared to the World Health Organization (WHO) classification. The present study assessed patients with COPD among different BMI categories according to two BMI classification systems: WHO and Asia-Pacific. PATIENTS AND METHODS: Patients with COPD aged 40 years or older from the Korean COPD Subtype Study cohort were selected for evaluation...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28789683/voluntary-running-exercise-protects-against-sepsis-induced-early-inflammatory-and-pro-coagulant-responses-in-aged-mice
#16
Karel Tyml, Scott Swarbreck, Cynthia Pape, Dan Secor, James Koropatnick, Qingping Feng, Ruud A W Veldhuizen, Sean E Gill
BACKGROUND: Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic patients are elderly (60 - 70 years). The objective of the present study was to examine the sepsis-induced inflammatory and pro-coagulant responses in aged mice. Since running exercise protects against a variety of diseases, we also examined the effect of voluntary running on septic responses in aged mice...
August 8, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28764134/exposure-to-polycyclic-aromatic-hydrocarbons-and-central-obesity-enhanced-risk-for-diabetes-among-individuals-with-poor-lung-function
#17
Jian Hou, Huizhen Sun, Xiji Huang, Yun Zhou, Youjian Zhang, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Some studies have shown an association between obesity or exposure to polycyclic aromatic hydrocarbons (PAHs) and the risk of diabetes. This study aimed to investigate the interaction of obesity and urinary monohydroxy-PAHs (OH-PAHs) on diabetes. Individuals (n = 2716) were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. They completed the physical examination, measurements of lung function, biochemical indices and urinary OH-PAHs levels. Additive effect of obesity and urinary ΣOH-PAHs levels on diabetes was assessed by calculating the relative excess risk due to interaction (RERI) and the attributable proportion (AP) due to interaction...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28740685/minimally-invasive-aortic-valve-replacement-in-high-risk-patient-groups
#18
REVIEW
Daniel Fudulu, Harriet Lewis, Umberto Benedetto, Massimo Caputo, Gianni Angelini, Hunaid A Vohra
Minimally invasive aortic valve replacement (AVR) aims to preserve the sternal integrity and improve postoperative outcomes. In low risk patients, this technique can be achieved with comparable mortality to the conventional approach and there is evidence of possible reduction in intensive care and hospital length of stay, transfusion requirement, renal dysfunction, improved respiratory function and increased patient satisfaction. In this review, we aim to asses if these benefits can be transferred to the high risk patient groups...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28737966/effect-of-obesity-on-sinonasal-disease-in-asthma
#19
S Kanagalingam, S S Shehab, D A Kaminsky, R A Wise, J E Lang, A E Dixon
OBJECTIVE: Sinonasal disease can contribute to poor asthma control. There are reports that link obesity with an increased prevalence of sinonasal disease, but no studies evaluating the severity of sinonasal disease in obese asthmatics, and how this impacts asthma control. The purpose of the current study was to determine if obesity is associated with increased severity of sinonasal disease, and/or affects response to nasal corticosteroid treatment in asthma. METHODS: This study included 236 adults participating in a 24-week randomized, double-masked, placebo-controlled study of nasal mometasone for the treatment of poorly controlled asthma...
July 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28728934/beyond-bmi-obesity-and-lung-disease
#20
REVIEW
Ubong Peters, Benjamin T Suratt, Jason H T Bates, Anne E Dixon
The worldwide prevalence of obesity has increased rapidly in the last 3 decades, and this increase has led to important changes in the pathogenesis and clinical presentation of many common diseases. This review article examines the relationship between obesity and lung disease, highlighting some of the major findings that have advanced our understanding of the mechanisms contributing to this relationship. Changes in pulmonary function related to fat mass are important, but obesity is much more than simply a state of mass loading, and BMI is only a very indirect measure of metabolic health...
July 17, 2017: Chest
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