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https://www.readbyqxmd.com/read/28335527/metabolic-disorder-in-chronic-obstructive-pulmonary-disease-copd-patients-towards-a-personalized-approach-using-marine-drug-derivatives
#1
REVIEW
Palma Lamonaca, Giulia Prinzi, Aliaksei Kisiliaou, Vittorio Cardaci, Massimo Fini, Patrizia Russo
Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease (COPD) patients. However, the exact correlation between obesity, which is a complex metabolic disorder, and COPD remains controversial. The current study summarizes a variety of drugs from marine sources that have anti-obesity effects and proposed potential mechanisms by which lung function can be modulated with the anti-obesity activity. Considering the similar mechanism, such as inflammation, shared between obesity and COPD, the study suggests that marine derivatives that act on the adipose tissues to reduce inflammation may provide beneficial therapeutic effects in COPD subjects with high body mass index (BMI)...
March 20, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28298897/plasma-ghrelin-levels-are-associated-with-anorexia-but-not-cachexia-in-patients-with-nsclc
#2
Susanne Blauwhoff-Buskermolen, Jacqueline A E Langius, Annemieke C Heijboer, Annemarie Becker, Marian A E de van der Schueren, Henk M W Verheul
Background and Aims: The ghrelin receptor is one of the new therapeutic targets in the cancer anorexia-cachexia syndrome. Previous studies revealed that plasma ghrelin levels were high in patients with anorexia nervosa and low in obese subjects. We studied to what extent ghrelin levels are related with anorexia and cachexia in patients with cancer. Materials and Methods: Fasted ghrelin levels were determined as well as anorexia and cachexia in patients with stage III/IV non-small cell lung cancer before chemotherapy...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28284316/the-effects-of-obesity-on-lung-volumes-and-oxygenation
#3
Stephen W Littleton, Aiman Tulaimat
INTRODUCTION: Obesity can cause hypoxemia by decreasing lung volumes to where there is closure of lung units during normal breathing. Studies describing this phenomenon are difficult to translate into clinical practice. We wanted to determine the lung volume measurements that are associated with hypoxemia in obese patients, and explore how we could use these measurements to identify them. METHODS: We collected pulmonary function test results and arterial blood gas data on 118 patients without obstruction on pulmonary function testing...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28280320/the-effect-of-obesity-on-patients-with-mild-chronic-obstructive-pulmonary-disease-results-from-knhanes-2010-to-2012
#4
Ju-Hee Park, Jung-Kyu Lee, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung
PURPOSE: A low body mass index has been associated with high mortalities in patients with chronic obstructive pulmonary disease (COPD), and studies reveal that obesity aggravates the clinical effects of COPD. We investigated the impact of obesity on patients newly identified with COPD. PATIENTS AND METHODS: This population-based, cross-sectional study, used data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted from 2010 to 2012...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28262207/sex-differences-in-the-effects-of-obesity-on-lung-volume
#5
Li Na Zhou, Qiong Wang, Chen Juan Gu, Ning Li, Jian Ping Zhou, Xian Wen Sun, Jun Zhou, Qing Yun Li
BACKGROUND: Obesity is linked to variation of lung volume; however, it is still unclear whether a sex difference exists. The study aimed to find out the effect of obesity on lung volume and sex difference among the Chinese population. METHOD: Pulmonary function test results were collected from 300 patients (aged 18 to ~80 years) with normal airway function and a wide range of body mass indexes (BMI). Measures of total lung capacity, vital capacity (VC), inspiratory capacity (IC), reserve volume, expiratory reserve volume (ERV) and functional reserve capacity (FRC) were analyzed by sex and different BMI groups...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28254764/follow-up-of-patients-with-uncontrolled-asthma-clinical-features-of-asthma-patients-according-to-the-level-of-control-achieved-the-coas-study
#6
Rosa Munoz-Cano, Alfons Torrego, Joan Bartra, Jaime Sanchez-Lopez, Rosa Palomino, Cesar Picado, Antonio Valero
Our aim was to study the asthma control achieved in patients with uncontrolled asthma who had received appropriate treatment according to the Global Initiative for Asthma (GINA) 2010 (valid at the time the study was designed), and to analyse the factors associated with a lack of asthma control.This was a multicentre study in routine clinical practice performed in patients with uncontrolled asthma according to GINA 2010. At visit 1, we recorded demographics, asthma characteristics and spirometry. We assessed asthma control using GINA 2010 criteria and the Asthma Control Test (ACT)...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28254428/the-behavioural-cognitive-and-neural-corollaries-of-blunted-cardiovascular-and-cortisol-reactions-to-acute-psychological-stress
#7
REVIEW
Douglas Carroll, Annie T Ginty, Anna C Whittaker, William R Lovallo, Susanne R de Rooij
Recent research shows that blunted cardiovascular and cortisol reactions to acute psychological stress are associated with adverse behavioural and health outcomes: depression, obesity, bulimia, and addictions. These outcomes may reflect suboptimal functioning of the brain's fronto-limbic systems that are needed to regulate motivated behaviour in the face of challenge. In support of this, brain imaging data demonstrate fronto-limbic hypoactivation during acute stress exposure. Those demonstrating blunted reactions also show impairments of motivation, including lower cognitive ability, more rapid cognitive decline, and poorer performance on motivation-dependent tests of lung function...
February 27, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28245609/lifestyle-risk-factors-for-weight-gain-in-children-with-and-without-asthma
#8
Megan E Jensen, Peter G Gibson, Clare E Collins, Jodi M Hilton, Lisa G Wood
A higher proportion of children with asthma are overweight and obese compared to children without asthma; however, it is unknown whether asthmatic children are at increased risk of weight gain due to modifiable lifestyle factors. Thus, the aim of this cross-sectional study was to compare weight-gain risk factors (sleep, appetite, diet, activity) in an opportunistic sample of children with and without asthma. Non-obese children with (n = 17; age 10.7 (2.4) years) and without asthma (n = 17; age 10.8 (2.3) years), referred for overnight polysomnography, underwent measurement of lung function, plasma appetite hormones, dietary intake and food cravings, activity, and daytime sleepiness...
February 25, 2017: Children
https://www.readbyqxmd.com/read/28244800/reduced-forced-vital-capacity-in-an-african-population-prevalence-and-risk-factors
#9
Daniel O Obaseki, Gregory E Erhabor, Olayemi F Awopeju, Olufemi O Adewole, Bamidele O Adeniyi, A Sonia Buist, Peter G Burney
RATIONALE: Black Africans have a reduced forced vital capacity compared with Caucasians, but the prevalence and determinants of reduced values are not well understood. OBJECTIVES: To evaluate the prevalence and factors leading to reduced forced vital capacity in a Nigerian population and to examine current theories regarding the determinants of this difference. METHODS: We studied the ventilatory function of 883 adults aged ≥40 years participating in the Burden of Obstructive Lung Disease (BOLD) study in Ile-Ife, Nigeria...
February 28, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28215237/severity-of-nocturnal-hypoxia-and-daytime-hypercapnia-predicts-cpap-failure-in-patients-with-copd-and-obstructive-sleep-apnea-overlap-syndrome
#10
Zuzana Kuklisova, Ruzena Tkacova, Pavol Joppa, Emiel Wouters, Manuel Sastry
BACKGROUND: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are independent risk factors for cardiovascular diseases. In patients with OSA and concurrent COPD, continuous positive airway pressure (CPAP) therapy improves survival. Nevertheless, a significant proportion of such patients do not tolerate CPAP. The aim of the present study was to analyze early predictors of CPAP failure in patients with OSA and concurrent COPD, and to evaluate the effects of bilevel positive airway pressure (BiPAP) in this high-risk group of patients...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28181198/influence-of-socioeconomic-and-anthropometric-factors-on-respiratory-function-in-female-university-students
#11
D Nowakowski, K Kliś, M Żurawiecka, A Dubrowski, Iwona Wronka
The purpose of this study was to evaluate lung function in healthy young female university students and to seek the relation of lung function to socioeconomic and anthropometric indices. The methodology consisted of spirometry tests, anthropometric measures and a questionnaire conducted in November of 2015 among 152 female university students. At first, lung function was analyzed for any relationship with socioeconomic factors and smoking. The results of a multi-factor analysis of variance demonstrate significant differences in the FEV1/FVC ratio depending on the general socioeconomic status...
February 9, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28166215/genetic-loci-associated-with-chronic-obstructive-pulmonary-disease-overlap-with-loci-for-lung-function-and-pulmonary-fibrosis
#12
Brian D Hobbs, Kim de Jong, Maxime Lamontagne, Yohan Bossé, Nick Shrine, María Soler Artigas, Louise V Wain, Ian P Hall, Victoria E Jackson, Annah B Wyss, Stephanie J London, Kari E North, Nora Franceschini, David P Strachan, Terri H Beaty, John E Hokanson, James D Crapo, Peter J Castaldi, Robert P Chase, Traci M Bartz, Susan R Heckbert, Bruce M Psaty, Sina A Gharib, Pieter Zanen, Jan W Lammers, Matthijs Oudkerk, H J Groen, Nicholas Locantore, Ruth Tal-Singer, Stephen I Rennard, Jørgen Vestbo, Wim Timens, Peter D Paré, Jeanne C Latourelle, Josée Dupuis, George T O'Connor, Jemma B Wilk, Woo Jin Kim, Mi Kyeong Lee, Yeon-Mok Oh, Judith M Vonk, Harry J de Koning, Shuguang Leng, Steven A Belinsky, Yohannes Tesfaigzi, Ani Manichaikul, Xin-Qun Wang, Stephen S Rich, R Graham Barr, David Sparrow, Augusto A Litonjua, Per Bakke, Amund Gulsvik, Lies Lahousse, Guy G Brusselle, Bruno H Stricker, André G Uitterlinden, Elizabeth J Ampleford, Eugene R Bleecker, Prescott G Woodruff, Deborah A Meyers, Dandi Qiao, David A Lomas, Jae-Joon Yim, Deog Kyeom Kim, Iwona Hawrylkiewicz, Pawel Sliwinski, Megan Hardin, Tasha E Fingerlin, David A Schwartz, Dirkje S Postma, William MacNee, Martin D Tobin, Edwin K Silverman, H Marike Boezen, Michael H Cho
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new...
March 2017: Nature Genetics
https://www.readbyqxmd.com/read/28143694/quantitative-computed-tomographic-imaging-based-clustering-differentiates-asthmatic-subgroups-with-distinctive-clinical-phenotypes
#13
Sanghun Choi, Eric A Hoffman, Sally E Wenzel, Mario Castro, Sean Fain, Nizar Jarjour, Mark L Schiebler, Kun Chen, Ching-Long Lin
BACKGROUND: Imaging variables, including airway diameter, wall thickness, and air trapping, have been found to be important metrics when differentiating patients with severe asthma from those with nonsevere asthma and healthy subjects. OBJECTIVE: The objective of this study was to identify imaging-based clusters and to explore the association of the clusters with existing clinical metrics. METHODS: We performed an imaging-based cluster analysis using quantitative computed tomography-based structural and functional variables extracted from the respective inspiration and expiration scans of 248 asthmatic patients...
January 29, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28115224/the-burden-of-obesity-in-asthma-and-copd-role-of-adiponectin
#14
REVIEW
Andrea Bianco, Ersilia Nigro, Maria Ludovica Monaco, Maria Gabriella Matera, Olga Scudiero, Gennaro Mazzarella, Aurora Daniele
The influence of obesity on development, severity and prognosis of both asthma and COPD is attracting growing interest. The impact of obesity on the respiratory system ranges from structural modifications (decline of total lung capacity) to humoral alterations. Adipose tissue strongly contributes to the establishment of an inflammatory state being an important source of adipokines. Amongst adipokines, adiponectin is an important component of organ cross talk with adipose tissue exerting protective effects on a variety of pathophysiological processes...
January 20, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28093732/long-term-hormone-therapy-for-perimenopausal-and-postmenopausal-women
#15
REVIEW
Jane Marjoribanks, Cindy Farquhar, Helen Roberts, Anne Lethaby, Jasmine Lee
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopausal women during and after cessation of treatment...
January 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28090302/three-dimensional-micro-computed-tomography-analysis-of-the-lung-vasculature-and-differential-adipose-proteomics-in-the-sugen-hypoxia-rat-model-of-pulmonary-arterial-hypertension
#16
Kelly J Shields, Kostas Verdelis, Michael J Passineau, Erin M Faight, Lee Zourelias, Changgong Wu, Rong Chong, Raymond L Benza
Pulmonary arterial hypertension (PAH) is a rare disease characterized by significant vascular remodeling. The obesity epidemic has produced great interest in the relationship between small visceral adipose tissue depots producing localized inflammatory conditions, which may link metabolism, innate immunity, and vascular remodeling. This study used novel micro computed tomography (microCT) three-dimensional modeling to investigate the degree of remodeling of the lung vasculature and differential proteomics to determine small visceral adipose dysfunction in rats with severe PAH...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28076945/effect-of-body-mass-index-on-pulmonary-function-in-children
#17
G Liyanage, B D Jayamanne, M Aaqiff, D Sriwardhana
Introduction: The relationship between obesity or overweight and pulmonary functions has not been investigated in Sri Lankan children previously. Therefore, we aimed to study the effects of obesity/overweight on dynamic lung functions in healthy school children in Sri Lanka. Methods: HASH(0x4b7c220) Results: Of 275 children 55 (20%) were ‘obese/ overweight’. BMI has no significant relationship to any of the pulmonary function parameters...
December 30, 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28017629/identifying-risk-of-future-asthma-attacks-using-uk-medical-record-data-a-respiratory-effectiveness-group-initiative
#18
John D Blakey, David B Price, Emilio Pizzichini, Todor A Popov, Borislav D Dimitrov, Dirkje S Postma, Lynn K Josephs, Alan Kaplan, Alberto Papi, Marjan Kerkhof, Elizabeth V Hillyer, Alison Chisholm, Mike Thomas
BACKGROUND: Asthma attacks are common, serious, and costly. Individual factors associated with attacks, such as poor symptom control, are not robust predictors. OBJECTIVE: We investigated whether the rich data available in UK electronic medical records could identify patients at risk of recurrent attacks. METHODS: We analyzed anonymized, longitudinal medical records of 118,981 patients with actively treated asthma (ages 12-80 years) and 3 or more years of data...
December 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27998872/-association-between-gender-and-lung-function-in-obese-asthmatic-children-after-inhaling-corticosteroids
#19
Ze-Hui Ye, Ying Huang
OBJECTIVE: To study the association between gender and lung function in obese asthmatic children before and after inhaling corticosteroids (ICS). METHODS: A total of 102 asthmatic boys (including 57 normal-weight and 45 obese boys) and 88 asthmatic girls (including 46 normal-weight and 42 obese girls) received ICS treatment for one year. Pulmonary functions were evaluated before and after the treatment for forced expiratory volume in one second (FEV1), forced vital capacity (FVC), maximal expiratory flow 25 (MEF25) and maximal expiratory flow 50 (MEF50)...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27976661/an-approach-to-interpreting-restrictive-spirometric-pattern-results-in-occupational-settings
#20
Federica Tafuro, Massimo Corradi
OBJECTIVES: The aim of this review is to provide an updated overview of definition, epidemiology, diagnostic algorithm and occupational exposures related to abnormal restrictive spirometrical pattern (RSP) in order to improve the correct interpretation of spirometry test results by occupational healthcare providers. METHODS: A review of the scientific English literature of the last 25 years was carried out with MEDLINE and related keywords [(restricti* AND spirometr*) AND occupational]...
December 13, 2016: La Medicina del Lavoro
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