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Haemodialysi

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https://www.readbyqxmd.com/read/28533146/bioactive-lipids-derived-from-arachidonic-acid-metabolism-in-different-types-of-renal-replacement-therapy
#1
Joanna Stępniewska, Barbara Dołęgowska, Kamila Puchałowicz, Edyta Gołembiewska, Kazimierz Ciechanowski
INTRODUCTION: Metabolism and plasma concentration of lipids and lipid-derived compounds play an important role in kidney physiology and pathological processes. The component of membrane phospholipids - arachidonic acid (AA) and its active derivatives - eicosanoids are involved in the development of hypertension, diabetes, inflammation and may contribute to progression of chronic kidney disease (CKD). The purpose of the study was to determine, whether the type of renal replacement therapy has an effect on eicosanoids metabolism...
May 19, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28532509/barriers-and-facilitators-to-healthcare-professional-behaviour-change-in-clinical-trials-using-the-theoretical-domains-framework-a-case-study-of-a-trial-of-individualized-temperature-reduced-haemodialysis
#2
Justin Presseau, Brittany Mutsaers, Ahmed A Al-Jaishi, Janet Squires, Christopher W McIntyre, Amit X Garg, Manish M Sood, Jeremy M Grimshaw
BACKGROUND: Implementing the treatment arm of a clinical trial often requires changes to healthcare practices. Barriers to such changes may undermine the delivery of the treatment making it more likely that the trial will demonstrate no treatment effect. The 'Major outcomes with personalized dialysate temperature' (MyTEMP) is a cluster-randomised trial to be conducted in 84 haemodialysis centres across Ontario, Canada to investigate whether there is a difference in major outcomes with an individualized dialysis temperature (IDT) of 0...
May 22, 2017: Trials
https://www.readbyqxmd.com/read/28532480/medication-adherence-perspectives-in-haemodialysis-patients-a-qualitative-study
#3
Saurav Ghimire, Ronald L Castelino, Matthew D Jose, Syed Tabish R Zaidi
BACKGROUND: End-stage kidney disease patients undergoing haemodialysis are prescribed with multiple complex regimens and are predisposed to high risk of medication nonadherence. The aims of this study were to explore factors associated with medication adherence, and, to examine the differential perspectives on medication-taking behaviour shown by adherent and nonadherent haemodialysis patients. METHODS: A qualitative exploratory design was used. One-on-one semi-structured interviews were conducted with 30 haemodialysis patients at the outpatient dialysis facility in Hobart, Australia...
May 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28530212/-measurements-of-vancomycin-concentrations-in-the-blood-a-method-of-personalization-the-antibiotic-therapy-in-patients-with-chronic-kidney-disease
#4
Joanna Pondel, Piotr Krajewski, Natalia Królikowska, Aleksandra Tobiasz, Hanna Augustyniak-Bartosik, Magdalena Hurkacz
Therapeutic Drug Monitoring is a recognized method of personalizing treatment, having particular application in patients with chronic kidney disease who have frequent infections, requiring administration of vancomycin. International guidelines indicate the need to adjust the dose of the drug to the state of renal function. The recommended therapeutic ranges of minimum and maximum levels should be achieved in order to increase the effectiveness and safety of treatment. AIM: The aim of this study was to evaluate the usefulness of measuring the concentration of vancomycin in patients with chronic kidney disease due to bacterial infection...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28529915/hemolytic-uremic-syndrome-in-adults-a-case-report
#5
Fabiel Gerardo Pérez-Cruz, Patricia Villa-Díaz, María Consuelo Pintado-Delgado, María Loreto Fernández Rodríguez, Ana Blasco-Martínez, María Pérez-Fernández
Thrombotic microangiopathies (TMA) are microvascular occlusive disorders characterized by platelet aggregation and mechanical damage to erythrocytes, clinically characterized by microangiopatic haemolytic anemia, thrombocytopenia and organ injury. We are reporting a case of a woman patient with severe hemolytic uremic syndrome associated to infectious diarrhoea caused by Shiga toxin-producing pathogen, who were admitted to our intensive care unit. The patient described developed as organ injury, neurological failure and acute renal failure, with need of haemodialysis technique...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28526396/the-impact-of-initial-misdiagnosis-of-ruptured-abdominal-aortic-aneurysms-on-lead-times-complication-rate-and-survival
#6
K Smidfelt, C Drott, K Törngren, J Nordanstig, J Herlitz, M Langenskiöld
OBJECTIVE/BACKGROUND: To investigate the frequency of initial misdiagnosis and the clinical consequences of an initial misdiagnosis of ruptured abdominal aortic aneurysms (rAAA). METHODS: This was a retrospective cohort study. Data from the Swedish National Registry for Vascular Surgery (Swedvasc) and medical charts were extracted for patients treated for rAAA in the West of Sweden in the period 2008-14. Initially misdiagnosed patients were compared with correctly diagnosed patients...
May 16, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28524236/commitment-to-care-the-most-important-coping-strategies-among-family-caregivers-of-patients-undergoing-haemodialysis
#7
Shahriar Salehi-Tali, Fazlollah Ahmadi, Kourosh Zarea, Malek Fereidooni-Moghadam
BACKGROUND: Caregivers of patients undergoing haemodialysis often experience an intensive burden of care; therefore, it is important to understand the type of strategies that are used by caregivers to adapt and to commit themselves to caring for another individual. AIM: The aim of this study was to explore the specific coping strategies used by family caregivers of patients undergoing haemodialysis. METHODS: In this qualitative study, 16 family caregivers of patients undergoing haemodialysis were selected through purposive sampling in four dialysis centres in south of Iran...
May 19, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28523048/what-to-eat-for-a-better-sleep-in-haemodialysis-patients-potential-role-of-b-vitamins-intake-and-appetite
#8
Dilek Ongan, Aysun Yuksel
OBJECTIVE: Sleeping disorders are common among Haemodialysis-HD patients. In addition to well-known factors, food consumption impact on sleep quality needs being discovered. Aim was to examine the nutrition-related factors that may influence sleep quality in HD patients. METHODS: One hundred and three patients in three HD centres participated. Data were collected with Pittsburgh Sleep Quality Index-PSQI and Questionnaire Form about socio-demographic characteristics and appetite...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28508973/phlegmasia-cerulean-dolens-complication-of-femoral-vein-catheterization
#9
M Hari Krishna Reddy, B Sangeetha, M Aruna, V Sarat Chandra, Anil C Venkata Kumar, R Ram, V Sivakumar
There are three less frequent manifestations of acute massive venous thrombosis and obstruction of the venous drainage of an extremity. They are phlegmasia alba dolens, phlegmasia cerulean dolens (PCD), and venous gangrene. The term PCD differentiates ischemia-associated massive venous thrombosis from phlegmasia alba dolens, which describes fulminant venous thrombosis without ischemia. We present a 55-year-old hypertensive, who presented with paedal oedema and breathlessness at rest. About a month prior to this admission, she suffered dislocation of left patella...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28502697/impact-of-high-flux-haemodialysis-on-the-probability-of-target-attainment-for-oral-amoxicillin-clavulanic-acid-combination-therapy
#10
Katrina Hui, Kashyap Patel, David C M Kong, Carl M J Kirkpatrick
Clearance of small molecules such as amoxicillin and clavulanic acid is expected to increase during high-flux haemodialysis, which may result in lower concentrations and thus reduced efficacy. To date, clearance of amoxicillin/clavulanic acid (AMC) during high-flux haemodialysis remains largely unexplored. Using published pharmacokinetic parameters, a two-compartment model with first-order input was simulated to investigate the impact of high-flux haemodialysis on the probability of target attainment (PTA) of orally administered AMC combination therapy...
May 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28500363/diffusion-weighted-imaging-of-the-kidneys-in-haemolytic-uraemic-syndrome
#11
Jochen Herrmann, Ulrich Wenzel, Stephanie Galler, Bjoern P Schoennagel, Jasmin D Busch, Magdalini Tozakidou, Kay U Petersen, Michaela Joekel, Peter Bannas, Jin Yamamura, Michael Groth, Gerhard Adam, Christian R Habermann
OBJECTIVES: To evaluate the kidneys of patients with haemolytic uraemic syndrome (HUS) using diffusion-weighted imaging (DWI) and Doppler ultrasound (US) compared with healthy controls. MATERIALS AND METHODS: Fifteen patients (mean age 33.3 years; three male; 12 female) with diarrhoea-positive HUS and 15 healthy volunteers were prospectively evaluated with DWI and Doppler US. A total apparent diffusion coefficient (ADCTOT), and ADCs predominantly reflecting microperfusion (ADCLOW) and diffusion (ADCHIGH) were calculated...
May 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28499421/patterns-of-use-and-appropriateness-of-antibiotics-prescribed-to-patients-receiving-haemodialysis-an-observational-study
#12
Katrina Hui, Michelle Nalder, Kirsty Buising, Aspasia Pefanis, Khai Y Ooi, Eugenie Pedagogos, Craig Nelson, Carl M J Kirkpatrick, David C M Kong
BACKGROUND: There are limited published data on the types and appropriateness of oral and intravenous (IV) antibiotics prescribed to patients receiving haemodialysis. This information is critical to optimise antibiotic prescribing. Therefore this study aims to describe the patterns of use and the appropriateness of oral and IV antibiotics prescribed to patients receiving haemodialysis. METHODS: This was a prospective, observational study across four community and two hospital inpatient haemodialysis units in Melbourne, Australia...
May 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28498615/understanding-the-impact-of-haemodialysis-on-uk-nhs-patients-wellbeing-a-qualitative-investigation
#13
Daniel J W Jones, Kate Harvey, John P Harris, Laurie T Butler, Emma C Vaux
AIMS AND OBJECTIVES: While haemodialysis (HD) is an effective treatment for end-stage renal disease (ESRD), the requirements and restrictions it imposes on patients can be onerous. The aim of the current study was to obtain UK National Health Service (NHS) patients' perspectives on the challenges arising from HD with the intention of identifying potential improvements. BACKGROUND: Depression rates are particularly high in those with ESRD, however, there is limited insight into the range of stressors associated with HD treatment within the NHS contributing to such high rates, particularly those of a cognitive or psychological nature...
May 12, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28494192/prooxidant-antioxidant-balance-hstni-and-hscrp-mortality-prediction-in-haemodialysis-patients-two-year-follow-up
#14
Tanja Antunovic, Aleksandra Stefanovic, Najdana Gligorovic Barhanovic, Milica Miljkovic, Danilo Radunovic, Jasmina Ivanisevic, Vladimir Prelevic, Nebojsa Bulatovic, Marina Ratkovic, Marina Stojanov
Oxidative stress and inflammation are highly intertwined pathophysiological processes. We analyzed the markers of these processes and high-sensitive troponin I (hsTnI) for mortality prediction in patients on haemodialysis. This study enrolled a total of 62 patients on regular haemodialysis. The patients were monitored for two years, and the observed outcomes were all-cause and cardiovascular mortality. Blood samples were taken before one dialysis session for analysis of the baseline concentrations of prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), total oxidative status (TOS), hsTnI, hsCRP and resistin...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28491228/-survival-among-chronic-hemodialysed-patient-in-cameroon
#15
Hermine Fouda, Gloria Ashuntantang, François Kaze, Marie-Patrice Halle
INTRODUCTION: Haemodialysis is the only renal replacement therapy available in Cameroon; 95% of patients has received subsidies by the State since 2002 and the number of dialysis centers is growing. However, since the opening of the first center in 1990, there are no data on survival in chronic dialysis patients. METHODS: We conducted a multicenter prospective cohort study of 15 months in order to assess mortality rates and factors that influence the survival of chronic hemodialysis patients in Cameroon...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28490481/vitamin-a-deficiency-due-to-chronic-malabsorption-an-ophthalmic-manifestation-of-a-systemic-condition
#16
James Cheshire, Sai Kolli
A 47-year-old woman presented with a 4-week history of progressive loss of vision, first manifesting as night blindness. Additionally, the patient reported frequent severe episodes of diarrhoea over the past month. Her medical history included end-stage renal failure for which she was currently on haemodialysis after a failed renal transplant, chronic pancreatitis and autonomic diabetes mellitus. Ophthalmological examination revealed severe bilateral corneal xerosis, bilateral Bitot's spots and inferior ulceration of the right cornea...
May 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28490014/aryl-hydrocarbon-receptor-activation-in-chronic-kidney-disease-role-of-uremic-toxins
#17
Jessyca S Brito, Natália A Borges, Marta Esgalhado, D''Angelo C Magliano, Christophe O Soulage, Denise Mafra
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients...
May 11, 2017: Nephron
https://www.readbyqxmd.com/read/28489901/characterization-and-proteomic-profile-of-extracellular-vesicles-from-peritoneal-dialysis-efflux
#18
Laura Carreras-Planella, Jordi Soler-Majoral, Cristina Rubio-Esteve, Sara Inés Lozano-Ramos, Marcella Franquesa, Josep Bonet, Maria Isabel Troya-Saborido, Francesc Enric Borràs
Peritoneal Dialysis (PD) is considered the best option for a cost-effective mid-term dialysis in patients with Chronic Renal Failure. However, functional failure of the peritoneal membrane (PM) force many patients to stop PD treatment and start haemodialysis. Currently, PM functionality is monitored by the peritoneal equilibration test, a tedious technique that often show changes when the membrane damage is advanced. As in other pathologies, the identification and characterization of extracellular vesicles (EVs) in the peritoneal dialysis efflux (PDE) may represent a non-invasive alternative to identify biomarkers of membrane failure...
2017: PloS One
https://www.readbyqxmd.com/read/28486916/are-markers-of-cardiac-dysfunction-useful-in-the-assessment-of-cardiovascular-risk-in-dialysis-patients
#19
Beata Franczyk, Anna Gluba-Brzózka, Piotr Bartnicki, Maciej Banach, Jacek Rysz
Cardiovascular morbidity and mortality of dialysis patients is a major problem in this group. The purpose of this study was also to evaluate whether any of studied markers are better than troponin in early detection of the occurrence of ventricular arrhythmias and prolongation of QT interval. This study included 45 patients undergoing haemodialysis. ECG Holter and echocardiographic examination were performed before and after dialysis. The concentration of markers: copeptin, GDF-15, HFABP and troponin were measured with the use of ELISA tests...
May 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28485814/partial-nephrectomy-versus-radical-nephrectomy-for-clinical-localised-renal-masses
#20
REVIEW
Frank Kunath, Stefanie Schmidt, Laura-Maria Krabbe, Arkadiusz Miernik, Philipp Dahm, Anne Cleves, Mario Walther, Nils Kroeger
BACKGROUND: Partial nephrectomy and radical nephrectomy are the relevant surgical therapy options for localised renal cell carcinoma. However, debate regarding the effects of these surgical approaches continues and it is important to identify and summarise high-quality studies to make surgical treatment recommendations. OBJECTIVES: To assess the effects of partial nephrectomy compared with radical nephrectomy for clinically localised renal cell carcinoma. SEARCH METHODS: We searched CENTRAL, MEDLINE, PubMed, Embase, Web of Science, BIOSIS, LILACS, Scopus, two trial registries and abstracts from three major conferences to 24 February 2017, together with reference lists; and contacted selected experts in the field...
May 9, 2017: Cochrane Database of Systematic Reviews
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