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A. Salama

Mohamed S Abdel Aziz, Hend E Salama
This work aims to study the effect of a vinyl-modified montmorillonite (VMT) on the physical and antimicrobial properties of chitosan-graft-polyacrylic acid superabsorbent (Ch-g-PA). Ch-g-PA was first optimized using Box-Behnken Design to obtain the maximum equilibrium swelling, and the model was efficient to express the experimental swelling data (R2  = 0.999). VMT was further added to the optimized Ch-g-PA in different contents 0, 4, 7 and 10 wt%. FTIR confirmed the successful synthesis of the copolymers and their nanocomposites...
May 16, 2018: International Journal of Biological Macromolecules
Heba Elmotasem, Hala K Farag, Abeer A A Salama
The objective of this study was to innovate an effective oral sustained release hepatoprotective formula for - the water soluble drug - caffeine. Caffeine is rapidly absorbed and eliminated which dictates frequent administration to achieve adequate therapeutic effect. A w/o Pickering emulsion incorporating caffeine in the internal phase was primed. It contained wheat germ oil and was stabilized by synthesized magnesium oxide nanoparticles (MgO NPs). Components selection was based on their antioxidant, hepatoprotective and anticarcinogenic effects...
May 16, 2018: International Journal of Pharmaceutics
Jiajing Qiu, Mohamed E Salama, Cing Siang Hu, Yan Li, Xiaoli Wang, Ronald Hoffman
The CD34- CD8α+ , sinusoid lining, littoral cells (LCs), and CD34+ CD8α- , splenic vascular endothelial cells (SVECs) represent 2 distinct cellular types that line the vessels within normal spleens and those of patients with myelofibrosis (MF). To further understand the respective roles of LCs and SVECs, each was purified from normal and MF spleens, cultured, and characterized. Gene expression profiling indicated that LCs were a specialized type of SVEC. LCs possessed a distinct gene expression profile associated with cytoskeleton regulation, cellular interactions, endocytosis, and iron transport...
May 22, 2018: Blood Advances
Azhar M Elwan, Aida A Salama, Abdelbaset M Sayed, Ahmad M Ghoneim, Aziza A Assaied, Fatma A Ibrahim, Hany A Shousha, Mohamed M M Elnasharty
The response of adult Wistar albino female rats toward two dose rates of gamma radiation delivered as acute dose of 7 Gy is investigated using classical methodologies as chemical, hematological and histological parameters in comparison with newly introduced dielectric parameters. Two groups of rats were exposed to γ ray with dose rates 533.35 mGy/min and 325.89 mGy/min. Then the irradiated groups were followed up for two weeks after irradiation. In case of higher dose rate, high percentage of animals was lost and there were substantial alterations in the dielectric parameters in addition to massive damage in liver and bone marrow cells...
May 10, 2018: Progress in Biophysics and Molecular Biology
Ossama Ashraf Ahmed, Eslam Safwat, Mohamed Omar Khalifa, Ahmed I Elshafie, Mohamed Hassan Ahmed Fouad, Mohamed Magdy Salama, Gina Gamal Naguib, Mohamed Mahmoud Eltabbakh, Ahmed Fouad Sherief, Sherief Abd-Elsalam
Background and Aims: As indicated by the World Health Organization (WHO), Egypt is positioned as the country with the world's highest prevalence of Hepatitis C virus (HCV). HCV is transmitted through unexamined blood transfusions, different employments of syringes, and poor cleansing, as per the WHO. Our study aimed at screening and management of chronic hepatitis C genotype 4 infected patients in Bardeen village, Sharkeya Governorate, Egypt, with Sofosbuvir plus Daclatasvir, as well as estimating the safety and efficacy of that regimen...
2018: International Journal of Hepatology
Ahmed M Ashour, Tarek H Elserry, Mohamed S Nosser, Zeyad Y Fayed, Mohamed Wael Samir, Alaa Fakher, Maamoun M Ashour, Mamdouh M Salama
Background: Spinal cord involvement by schistosomiasis is considered to be rare. Clinical presentation of spinal schistosomiasis ranges from radicular pain to myelopathy causing flaccid paraplegia, bladder incontinence, and dysesthesia. We reported six cases with spinal schistosomiasis. Methodology: We did a retrospective analysis of the records in our department from March 1995 to March 2015, and we found that six cases of proved spinal schistosomiasis were documented, with follow-up period more than a year, aiming to find an assumption for a guideline for this ambiguous issue...
January 2018: Journal of Craniovertebral Junction and Spine
William L Heaton, Anna V Senina, Anthony D Pomicter, Mohamed E Salama, Phillip M Clair, Dongqing Yan, Russell N Bell, Jeremy M Gililland, Josef T Prchal, Thomas O'Hare, Michael W Deininger
Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF responsiveness in MF cells are unknown. We show that the proportion of marrow (BM) cells expressing TNF is increased in MF compared to controls, with the largest differential in primitive cells. Blockade of TNF receptor 2 (TNFR2), but not TNFR1, selectively inhibited colony formation by MF CD34+ and mouse JAK2V617F progenitor cells. Microarray of mouse MPN revealed reduced expression of X-linked inhibitor of apoptosis (Xiap) and mitogen-activated protein kinase 8 (Mapk8) in JAK2V617F relative to JAK2WT cells, which were normalized by TNFR2 but not TNFR1 blockade...
April 18, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Kathryn P Lowry, Lior Z Braunstein, Konstantinos P Economopoulos, Laura Salama, Constance D Lehman, G Scott Gazelle, Elkan F Halpern, Catherine S Giess, Alphonse G Taghian, Janie M Lee
PURPOSE: To identify predictors of poor mammography surveillance outcomes based on clinico-pathologic features. METHODS: This study was HIPAA compliant and IRB approved. We performed an electronic medical record review for a cohort of women with American Joint Committee on Cancer (AJCC) Stage I or II invasive breast cancer treated with breast conservation therapy who developed subsequent in-breast treatment recurrence (IBTR) or contralateral breast cancer (CBC)...
May 10, 2018: Breast Cancer Research and Treatment
Eleana Ntatsaki, Alba Velo-Garcia, Vassilios S Vassiliou, Alan D Salama, David A Isenberg
Lupus nephritis (LN) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE) often leading to end-stage renal failure (ESRF) and necessitating renal transplantation (rTp). Optimal timing of rTp in SLE patients with ESRF is uncertain and could potentially affect survival. We investigated the time spent on dialysis before rTp and survival following rTp in a cohort of SLE patients. Retrospective analysis of all adult SLE patients receiving rTp over a 40-year period (1975-2015) in two tertiary UK centres...
May 11, 2018: Clinical Rheumatology
Reda Salem, Ibrahim A Arif, Mohamed Salama, Gamal E H Osman
Psorosis is a damaging disease of citrus that is widespread in many parts of the world. Citrus psorosis virus (CPsV), the type species of the genus Ophiovirus, is the putative causal agent of psorosis. Detection of CPsV by laboratory methods, serology in particular is a primary requirement for large-scale surveys but their production has been impaired by the difficulty of obtaining sufficient clean antigen for immunization. Specific PAbs against coat protein were produced in E. coli using recombinant DNA approach...
May 2018: Saudi Journal of Biological Sciences
Mohammad Peikari, Sherine Salama, Sharon Nofech-Mozes, Anne L Martel
Completely labeled pathology datasets are often challenging and time-consuming to obtain. Semi-supervised learning (SSL) methods are able to learn from fewer labeled data points with the help of a large number of unlabeled data points. In this paper, we investigated the possibility of using clustering analysis to identify the underlying structure of the data space for SSL. A cluster-then-label method was proposed to identify high-density regions in the data space which were then used to help a supervised SVM in finding the decision boundary...
May 8, 2018: Scientific Reports
Wilhelm Roell, Alexandra M Klein, Martin Breitbach, Torsten S Becker, Ashish Parikh, Jane Lee, Katrin Zimmermann, Shaun Reining, Beth Gabris, Annika Ottersbach, Robert Doran, Britta Engelbrecht, Miriam Schiffer, Kenichi Kimura, Patricia Freitag, Esther Carls, Caroline Geisen, Georg D Duerr, Philipp Sasse, Armin Welz, Alexander Pfeifer, Guy Salama, Michael Kotlikoff, Bernd K Fleischmann
Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI). Biological correction of the conduction inhomogeneity that underlies re-entry could be a major advance in infarction therapy. As minimal increases in conduction of infarcted tissue markedly influence VT susceptibility, we reasoned that enhanced propagation of the electrical signal between non-excitable cells within a resolving infarct might comprise a simple means to decrease post-infarction arrhythmia risk...
May 8, 2018: Scientific Reports
Rohit Tandon, Mohammed J Arisha, Navin C Nanda, Sooraj Kumar, Gurpreet S Wander, Swetha Srialluri, Hassan Kamel, Ahmed Y Salama
Left atrial appendage aneurysm (LAA AN) is a rare disease entity, which can be congenital or acquired in nature. We report an adult patient with LAA AN presenting with anginal chest pain in whom live/real time three-dimensional transthoracic echocardiography (3DTTE) provided incremental value over the two-dimensional (2D) technique in providing a more comprehensive assessment of the lesion. A literature review of the salient features of LAA AN is also provided in a tabular form.
May 7, 2018: Echocardiography
Rosana Salama-Bello, Jose R Duncan, Samantha L Howard, Jun Song, Mauro H Schenone
OBJECTIVES: Abnormal placentation is an important factor in the pathogenesis of preeclampsia. As a result of diminished blood flow, the incidence of preeclampsia might be higher in patients with laterally located placentas compared to patients with centrally located placentas. The objective of this study was to evaluate the relationship between placental location and the development of hypertensive disorders of pregnancy. METHODS: Patients with singleton pregnancies who were seen in our ultrasound unit and delivered at our institution from October 2014 to April 2015 were included...
May 6, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Salama A Ouf, Sobhi M Gomha, Mohamed Eweis, Ahmed S Ouf, Ihab A Sharawy
A series of fourteen novel synthesized arylazothiazole and arylhydrazothiazole derivatives were tested for their antifungal activity and structure-activity relationship. The activity of the compounds depends mainly on the side chains of the nucleus compound. The antifungal activity was more significant when both side chains are aromatic > one aromatic and one aliphatic and substituted aromatic with CH3 or OCH3  > non-substituted > substituted aromatic with chloro- or nitro-groups. Thiazole derivatives 7a, 7c, 7e, 7f, 7 g, 7i, 7 m, and 11a showed the most effective as antifungal compounds and were comparable with fluconazole as antifungal reference drug when investigated against Candida albicans, Microsporum gypseum and Trichophyton mentagrophytes...
April 27, 2018: Bioorganic & Medicinal Chemistry
Hend E Salama, Mohamed S Abdel Aziz, Magdy W Sabaa
Novel bioactive edible films synthesized from sodium alginate (A) and chitosan biguanidine hydrochloride (CG) with different weight percents were successfully prepared. 13 C NMR and 1 H NMR confirmed the successful guanidylation of chitosan. Fourier transform infrared confirmed the successful reaction between CG and A. The interaction between CG and A was confirmed through the reduction of the crystalline peaks using wide-angle X-ray diffraction of both CG and A. Thermogravimetric analysis confirmed that CG enhanced the thermal stability of films as detected from the calculated Integral Procedure Decomposition Temperature (IPDT) values...
May 1, 2018: International Journal of Biological Macromolecules
Ahmed M Youssef, Samah M El-Sayed, Hoda S El-Sayed, Heba H Salama, Faiza M Assem, Mohamed H Abd El-Salam
Bionanocomposites have attracted a tremendous level of consideration as alternatives for a broad group of commercial materials based on petroleum-derived compounds and used for coating cheese. Sustainable, economical and environmentally compatible materials based on chitosan (CS), poly vinyl alcohol (PVA), glycerol (Gy) and titanium dioxide nanoparticles (TiO2 -NPs) were prepared. Moreover, the prepared bionanocomposites (CS/PVA/Gy/TiO2 -NPs) were characterized using XRD, SEM, TEM, WVTR and mechanical strength...
April 30, 2018: International Journal of Biological Macromolecules
Abdullah Abdullah, George Eigbire, Amr Salama, Abdul Wahab, Mohanad Awadalla, Ryan Hoefen, Richard Alweis
BACKGROUND: Delirium is associated with worse outcomes in critically ill patients. In the subset of patients with myocardial infarction (MI), the impact on clinical outcomes of delirium is not as well elucidated. HYPOTHESIS: Delirium is associated with increased mortality in patients hospitalized for MI METHODS: The study used data from the National Inpatient Sample (NIS) 2012 - 2014, Healthcare Cost and Utilization Project (HCUP). We included discharges associated with the primary diagnosis of MI using the relevant ICD-9-CM codes...
May 1, 2018: Clinical Cardiology
Nevien K Abdelkhalek, Mohamed A El-Adl, Mohamed F Salama, Bassem Elmishmishy, Mayar O Ali, Ahmed El-Ashram, Mohamed F Hamed, Moustafa A Al-Araby
Trichodinids are peritrichous ciliated protozoa that affect both wild and cultured fishes. Several Trichodina species have low host specificity and are morphologically distinct, facilitating their identification based primarily on the presence of adhesive discs and the number of attached denticles. A trichodinid species named Trichodina compacta was first reported by Van As and Basson (1989) (Protozoa: Ciliophora: Peritrichia). However, in trichodinid infestations, morphological characteristics are insufficient for identifying the infesting species...
May 1, 2018: Parasitology Research
Azza Saad Ibrahim, Mona Mohamed Eldeeb, Ola Ahmed Salama, Mona Mohamed Rashad, Khaled Mohamed Okasha
OBJECTIVES: Helicobacter pylori (H. pylori) is a common gastric infection associated with extragastric conditions. The association between H. pylori infection and obesity is unclear. H. pylori may affect gut hormones involved in food intake and energy expenditure. The aim of this study is to evaluate ghrelin/obestatin balance and leptin in obese subjects with H. pylori infection. METHODS: Sixty healthy volunteers were divided into: obese and non-obese groups. Each group was divided into H...
April 1, 2018: Endocrine Regulations
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