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A. Salama

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https://www.readbyqxmd.com/read/28048465/su-f-t-591-sbrt-treatment-of-multiple-extracranial-oligometastases-using-a-single-isocenter-with-distinct-optimizations-sido
#1
M Trager, J Adamson, J Salama
PURPOSE: A new development in linac-based intracranial radiosurgery is treatment of multiple targets using single isocenter VMAT, which dramatically reduces treatment time while maintaining high conformality and dose gradient. Our purpose is to translate this technique to extracranial SBRT of oligometastases and address additional challenges such as interplay from motion and setup uncertainties. METHODS: We propose SIDO (Single Isocenter with Distinct Optimizations) planning in which all VMAT arcs share an isocenter but each arc treats only one target...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045324/evaluation-of-tablet-pc-as-a-tool-for-teaching-tooth-brushing-to-children
#2
F Salama, I Abobakr, N Al-Khodair, M Al-Wakeel
AIM: This study evaluated the effect of a single time tooth brushing instruction using video on a tablet PC (Apple iPad) compared to operator presentation using jaw model for plaque removal. METHODS: This cross-sectional study included a convenience sample of 100 children divided into two groups. For Group 1 brushing was demonstrated to the child by the operator with the use of a jaw model. This demonstration was videotaped for subsequent use in Group 2 using a tablet PC (Apple iPad)...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28043586/assessment-of-diabetes-among-tuberculosis-patients-presenting-at-a-tertiary-care-facility-in-pakistan
#3
Muhammad Irfan, Naseem Salahuddin, Qamar Masood, Owais Ahmed, Umme Salama Moosajee, Zahra Hasan
OBJECTIVE/BACKGROUND: Pakistan ranks sixth among high-tuberculosis (TB)-burden countries worldwide and fifth worldwide for diabetes incidence. Although both these factors are independently known, the rate of diabetes among TB patients is not well known. We aimed to determine the prevalence of diabetes among patients with TB presenting at tertiary care health centers in Karachi, Pakistan. METHODS: A total of 216 patients with TB were recruited and their blood samples were taken for testing of glycosylated hemoglobin (HbA1c) and random blood sugar...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28040628/two-dimensional-analytic-modeling-of-acoustic-diffraction-for-ultrasonic-beam-steering-by-phased-array-transducers
#4
Tiansi Wang, Chong Zhang, Aleksandar Aleksov, Islam Salama, Aravinda Kar
Phased array ultrasonic transducers enable modulating the focal position of the acoustic waves, and this capability is utilized in many applications, such as medical imaging and non-destructive testing. This type of transducers also provides a mechanism to generate tilted wavefronts in acousto-optic deflectors to deflect laser beams for high precision advanced laser material processing. In this paper, a theoretical model is presented for the diffraction of ultrasonic waves emitted by several phased array transducers into an acousto-optic medium such as TeO2 crystal...
December 9, 2016: Ultrasonics
https://www.readbyqxmd.com/read/28032679/acr-appropriateness-criteria-%C3%A2-nasal-cavity-and-paranasal-sinus-cancers
#5
Farzan Siddiqui, Richard V Smith, Sue S Yom, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Ehab Y Hanna, Christopher U Jones, Shlomo A Koyfman, Harry Quon, John A Ridge, Nabil F Saba, Francis Worden, Min Yao, Joseph K Salama
The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios...
December 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/28029430/reduced-human-transitional-b-cell-t1-t2-ratio-is%C3%A2-associated-with-subsequent-deterioration-in%C3%A2-renal-allograft-function
#6
Aravind Cherukuri, Alan D Salama, Clive R Carter, Douglas Landsittel, Gururaj Arumugakani, Brendan Clark, David M Rothstein, Richard J Baker
Human transitional B cells express relatively high IL-10 and low TNF-α levels, which correlate with B regulatory activity in vitro. Herein, we aim to further define B regulatory phenotype and determine whether B regulatory activity can serve as a prognostic marker for renal allograft dysfunction (graft loss or 2-fold fall in estimated glomerular filtration rate). Transitional B cells can be divided into T1 and T2 subsets based on surface phenotype. T1 cells express a significantly higher ratio of IL-10 to TNF-α than T2 cells or other B subsets...
October 28, 2016: Kidney International
https://www.readbyqxmd.com/read/28017873/open-reduction-internal-fixation-versus-percutaneous-iliosacral-screw-fixation-for-unstable-posterior-pelvic-ring-disruptions
#7
Mohamed Mansour Elzohairy, Adel Mohamed Salama
BACKGROUND: Surgical stabilization of posterior pelvic ring fractures can be achieved by either open or closed methods. They all provide a comparable biomechanical stability. The aim of the present study is to comparethe clinical results of both techniques for treating posterior pelvic ring injuries. MATERIAL AND METHODS: Seventy patientsoperated for unstable posterior pelvic ring disruptions wereretrospectively reviewed. We compared 35 patients treated by open reduction internal fixation (ORIFgroup)versus35 patients stabilized by using closed reduction and percutaneous iliosacral screw fixation (CRIF group) under fluoroscopic guidance...
December 22, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28011127/anticandidal-antibacterial-cytotoxic-and-antioxidant-activities-of-calendula-arvensis-flowers
#8
A-M Abudunia, I Marmouzi, M E A Faouzi, Y Ramli, J Taoufik, N El Madani, E M Essassi, A Salama, K Khedid, M Ansar, A Ibrahimi
Calendula arvensis (CA) is one of the important plants used in traditional medicine in Morocco, due to its interesting chemical composition. The present study aimed to determine the anticandidal, antioxidant and antibacterial activities, and the effects of extracts of CA flowers on the growth of myeloid cancer cells. Also, to characterize the chemical composition of the plant. Flowers of CA were collected based on ethnopharmacological information from the villages around the region Rabat-Khemisset, Moroccco...
December 20, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28005194/dapsone-7-5-gel-a-review-in-acne-vulgaris
#9
Zaina T Al-Salama, Emma D Deeks
Dapsone 7.5% gel (Aczone(®)) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. In two phase III trials of 12 weeks' duration in patients aged ≥12 years with moderate acne vulgaris, once-daily dapsone 7.5% gel reduced acne severity (as per the Global Acne Assessment Score) and lesion counts versus vehicle...
December 22, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28004619/high-occurrence-and-unusual-serotype-diversity-of-non-typhoidal-salmonella-in-non-clinical-niches-angola
#10
P Antunes, J Campos, J Mourão, T G Ribeiro, C Novais, L Peixe
Non-typhoidal Salmonella is an important burden, particularly in developing countries of the African region. We report for the first time in Angola, a sub-Saharan African country with commercial/travel relationships with Europe, an unexpectedly high occurrence of Salmonella (n = 12/63, 19%) from a high diversity of sources, particularly farm and wild animals. The detection of diverse serotypes (n = 12), involving putative new S. enterica subsp. salamae serotypes, is also of note, reinforcing the need for a comprehensive surveillance in Angola critical to identify animal/food/environmental sources of salmonellosis with impact on animal health, local people, tourists and exported products...
December 22, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/28001314/new-aspects-on-the-efficacy-of-high-dose-intravenous-immunoglobulins-in-patients-with-autoimmune-thrombocytopenia
#11
B Mayer, F Depré, F Ringel, A Salama
BACKGROUND AND OBJECTIVES: The clinical significance of autoimmune thrombocytopenia (ITP) is reflected by bleeding and/or an increased bleeding risk due to low platelet counts. In most cases, treatment with high-dose (1-2 g/kg body weight) intravenous immunoglobulin has been demonstrated to result in an increase in platelet counts after one day of treatment. Until now, there is little information on the true beginning of therapy effect in patients treated with high-dose intravenous immunoglobulin...
December 21, 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27998799/phospholipid-complex-enriched-micelles-a-novel-drug-delivery-approach-for-promoting-the-antidiabetic-effect-of-repaglinide
#12
Ahmed Alaa Kassem, Sameh Hosam Abd El-Alim, Mona Basha, Abeer Salama
To enhance the oral antidiabetic effect of repaglinide (RG), a newly emerging approach, based on the combination of phospholipid complexation and micelle techniques, was employed. Repaglinide-phospholipid complex (RG-PLC) was prepared by the solvent-evaporation method then characterized using Differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR) and X-ray powder diffraction (XPRD). The results revealed obvious disappearance of the characteristic peaks of the prepared RG-PLCs confirming the formation of drug-phospholipid complex...
December 17, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27997619/intranasal-chromium-induces-acute-brain-and-lung-injuries-in-rats-assessment-of-different-potential-hazardous-effects-of-environmental-and-occupational-exposure-to-chromium-and-introduction-of-a-novel-pharmacological-and-toxicological-animal-model
#13
Abeer Salama, Rehab Hegazy, Azza Hassan
Chromium (Cr) is used in many industries and it is widely distributed in the environment. Exposure to Cr dust has been reported among workers at these industries. Beside its hazardous effects on the lungs, brain injury could be induced, as the absorption of substances through the nasal membrane has been found to provide them a direct delivery to the brain. We investigated the distribution and the effects of Cr in both brain and lung following the intranasal instillation of potassium dichromate (inPDC) in rats...
2016: PloS One
https://www.readbyqxmd.com/read/27989826/development-and-optimization-of-self-assembling-nanosystem-for-intra-articular-delivery-of-indomethacin
#14
Rabab Kamel, Alaa H Salama, Azza A Mahmoud
Osteoarthritis is a propagated debilitating condition affecting patients' quality of life. Intra-articular injection approach was investigated as a localized treatment strategy providing: site-specific delivery, decreased side effects and, increased patient compliance. A 3(2) full factorial experimental design was employed to prepare the indomethacin-loaded self-assembling nanosystems (SANS). The surfactant (Poloxamer 407/Tetronic 90R4) ratio and the poly(lactic-co-glycolic acid) (PLGA) concentration significantly affected encapsulation efficiency and drug release (p<0...
October 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27984651/neoadjuvant-long-course-chemoradiation-remains-strongly-favored-over-short-course-radiotherapy-by-radiation-oncologists-in-the-united-states
#15
Yvonne M Mowery, Joseph K Salama, S Yousuf Zafar, Harvey G Moore, Christopher G Willett, Brian G Czito, M Benjamin Hopkins, Manisha Palta
BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes regarding SC-RT and LC-CRT for patients with rectal cancer. METHODS: The authors distributed a survey to 1701 radiation oncologists regarding treatment of neoadjuvant rectal cancer. Respondents were asked questions regarding the number of patients with rectal cancer treated, preference for SC-RT versus LC-CRT, and factors influencing regimen choice...
December 16, 2016: Cancer
https://www.readbyqxmd.com/read/27976047/chemical-composition-and-antimicrobial-activity-of-essential-oils-of-selected-apiaceous-plants-growing-in-egypt
#16
N Khalil, M Ashour, S Fikry, A NaserSingab, O Salama
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27936050/gene-targeted-mice-with-the-human-troponin-t-r141w-mutation-develop-dilated-cardiomyopathy-with-calcium-desensitization
#17
Mohun Ramratnam, Guy Salama, Ravi K Sharma, David Wen Rui Wang, Stephen H Smith, Sanjay K Banerjee, Xueyin N Huang, Lindsey M Gifford, Michele L Pruce, Bethann E Gabris, Samir Saba, Sanjeev G Shroff, Ferhaan Ahmad
Most studies of the mechanisms leading to hereditary dilated cardiomyopathy (DCM) have been performed in reconstituted in vitro systems. Genetically engineered murine models offer the opportunity to dissect these mechanisms in vivo. We generated a gene-targeted knock-in murine model of the autosomal dominant Arg141Trp (R141W) mutation in Tnnt2, which was first described in a human family with DCM. Mice heterozygous for the mutation (Tnnt2R141W/+) recapitulated the human phenotype, developing left ventricular dilation and reduced contractility...
2016: PloS One
https://www.readbyqxmd.com/read/27929450/disposable-paper-based-inkjet-printed-humidity-and-h%C3%A2-s-gas-sensor-for-passive-sensing-applications
#18
Abdul Quddious, Shuai Yang, Munawar M Khan, Farooq A Tahir, Atif Shamim, Khaled N Salama, Hammad M Cheema
An inkjet-printed, fully passive sensor capable of either humidity or gas sensing is presented herein. The sensor is composed of an interdigitated electrode, a customized printable gas sensitive ink and a specialized dipole antenna for wireless sensing. The interdigitated electrode printed on a paper substrate provides the base conductivity that varies during the sensing process. Aided by the porous nature of the substrate, a change in relative humidity from 18% to 88% decreases the electrode resistance from a few Mega-ohms to the kilo-ohm range...
December 6, 2016: Sensors
https://www.readbyqxmd.com/read/27915204/powerpiinc-preoperative-window-of-endocrine-therapy-provides-information-to-increase-compliance-trial-changes-in-tumor-proliferation-index-and-quality-of-life-with-7-days-of-preoperative-tamoxifen
#19
Adam L Cohen, Rachel E Factor, Kathi Mooney, Mohamed E Salama, Mark Wade, Victoria Serpico, Emily Ostrander, Edward Nelson, Jane Porretta, Cindy Matsen, Philip Bernard, Ken Boucher, Leigh Neumayer
OBJECTIVES: A decrease in Ki67 during neoadjuvant therapy predicts response to tamoxifen. Previous trials have shown a decreased Ki67 in breast tumors with as little as two or more weeks of preoperative tamoxifen. Shortening the preoperative treatment time in window of opportunity clinical trials makes these trials more attractive to women. POWERPIINC examined the effect of 7 days of preoperative tamoxifen on breast tumor proliferation and patient symptoms. METHODS: Women with untreated stage I/II, ER-positive, invasive breast cancer with no contraindications to tamoxifen were enrolled...
February 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27909994/cabozantinib-a-review-in-advanced-renal-cell-carcinoma
#20
Zaina T Al-Salama, Gillian M Keating
The multiple tyrosine kinase inhibitor (TKI) cabozantinib (Cabometyx™) is approved in the USA for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior antiangiogenic therapy. In the EU, cabozantinib is indicated for the treatment of advanced RCC in adults following prior vascular endothelial growth factor (VEGF)-targeted therapy. In adults with advanced or metastatic clear-cell RCC who had previously received VEGF receptor (VEGFR) TKIs, progression-free survival (PFS) and overall survival (OS) were significantly prolonged in patients who received oral cabozantinib versus oral everolimus in the pivotal METEOR trial...
December 2016: Drugs
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