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Anti-IgA

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https://www.readbyqxmd.com/read/27708950/differential-assay-reactivity-of-immunglobulin-a-anti-%C3%A3-2-glycoprotein-i-antibodies-implications-for-the-clinical-interpretation-of-antiphospholipid-antibody-testing
#1
David B Hood, Karin R Snyder, Tammy R Buckner, Beth L Hurley, Kelly R Pitts, Luis R Lopez
OBJECTIVE: The routine measurement of IgA anticardiolipin (aCL) and IgA anti-β2 glycoprotein I (anti-β2 GPI) antibodies remain controversial despite several studies demonstrating an association with thromboembolic disease in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This controversy may be a contributing factor for the current under use of IgA antiphospholipid antibodies. We aimed to investigate the nature of discrepant IgA anti-β2 GPI reactivity to help define the diagnostic value of IgA antiphospholipid antibodies...
December 2015: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27531803/-study-on-immunoglobulin-a-deficiency-igad-in-chinese-shanghai-blood-donors
#2
Ping Lu, Bing Ling, Ning Wang, Lennart Hammarstrom
UNLABELLED: Objective:To calculate the prevalence of IgAD in a replicate cohort of the Chinese Han population in Shanghai area by screening blood donors and to study the genetic difference of IgAD individuals in the Mongoloid population. METHODS: The prevalence of IgAD in a large number of Chinese blood donors (n=61624) in Shanghai area was investigated. The immunoglobulin class, IgG subclass and anti-IgA serum levels were measured among the IgAD donors. These donors were subsequently tissue typed and the allele frequency was compared with the Shanghai bone marrow donor HLA registry...
August 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27438709/immunohistochemical-analysis-of-iga-expression-differentiates-igg4-related-disease-from-plasma-cell-type-castleman-disease
#3
Akihiro Manabe, Takuro Igawa, Mai Takeuchi, Yuka Gion, Tadashi Yoshino, Yasuharu Sato
Plasma cell-type Castleman disease (PCD) is often encountered when differentiating IgG4-related disease (IgG4-RD). Given that serum IgA is often elevated in Castleman disease, we investigated whether IgA expression levels in histological specimens can be used to differentiate between the two diseases. Lymph node lesions obtained from 12 IgG4-RD and 11 PCD patients were analysed by immunohistochemistry with anti-IgG, -IgG4, and -IgA antibodies. In addition to all 12 cases of IgG4-RD, 8/11 cases (72.7 %) of PCD also met the diagnostic criteria of IgG4-RD (serum IgG4 ≥135 mg/dl and IgG4/IgG-positive cells ≥40 %)...
July 20, 2016: Medical Molecular Morphology
https://www.readbyqxmd.com/read/27412077/anaphylaxis-to-ivig
#4
Sharon Julie Williams, Sudhir Gupta
Anaphylactic reactions are a known complication in some IgA-deficient patients receiving blood or plasma transfusions. It is of particular interest that anaphylaxis has been observed in patients with common variable immunodeficiency (CVID) who are receiving intravenous gammaglobulin (IVIG), and in that, although these patients have an impaired response to common vaccines, they retain the ability to produce autoantibodies. In this study, we review IgA antibodies (both IgG- and IgE-mediated reactions) in patients with CVID and hypogammaglobulinemia, anaphylaxis in antibody immunodeficient patients receiving IVIG, and proposed mechanisms of desensitization and prevention of anaphylactic reactions in immunodeficient patients receiving IVIG...
July 13, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27322740/investigating-b-cell-development-natural-and-primary-antibody-responses-in-ly-6a-sca-1-deficient-mice
#5
Morgan A Jones, Sean DeWolf, Vimvara Vacharathit, Michelle Yim, Stacey Spencer, Anil K Bamezai
Ly-6A/Stem cell antigen-1 (Ly-6A/Sca-1) is a glycosylphosphatidylinositol-anchored protein expressed on many cell types including hematopoietic stem cells (HSCs) and early lymphoid-specific progenitors. Ly-6A/Sca-1 is expressed on CD4+ T cells and plays a role in regulating cellular responses to foreign antigens. The role of Ly-6A/Sca-1 in primary antibody responses has not been defined. To investigate whether Ly-6A/Sca-1 functions in humoral immunity, we first injected Ly-6A/Sca-1-deficient and wild-type control mice with chicken ovalbumin (c-Ova) protein mixed with an adjuvant...
2016: PloS One
https://www.readbyqxmd.com/read/27190527/anaphylaxis-to-igiv-in-immunoglobulin-na%C3%A3-ve-common-variable-immunodeficiency-patient-in-the-absence-of-igg-anti-iga-antibodies-successful-administration-of-low-iga-containing-immunoglobulin
#6
Asal Gharib, Caroline Caperton, Sudhir Gupta
Although severe reactions to immunoglobulin preparations have been frequently reported, IgE antibodies against IgA are usually not investigated; and occur predominantly in previously sensitized patients. The purpose is to report anaphylaxis to IGIV during initial infusion in a patient with common variable immunodeficiency with absent IgA without prior sensitization and in the absence of detectable IgG anti-IgA antibodies, and positive skin tests for immediate hypersensitivity to four different preparations of IGIV, one subcutaneous immunoglobulin preparation, and to purified IgA...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/26862316/mycoplasma-pneumoniae-as-a-trigger-for-henoch-sch%C3%A3-nlein-purpura-in-children
#7
Elżbieta Kuźma-Mroczkowska, Małgorzata Pańczyk-Tomaszewska, Agnieszka Szmigielska, Hanna Szymanik-Grzelak, Maria Roszkowska-Blaim
Mycoplasma pneumoniae is one of the most common causes of respiratory tract infections in children. Extrapulmonary manifestations are seen in up to 25% of infected patients. Extrapulmonary complications are associated with the central nervous system, gastrointestinal tract, skin changes, myocarditis, pericarditis, hemolytic anemia, thrombocytopenia and thrombosis. The majority of extrapulmonary symptoms are associated with skin changes such as exanthematous skin eruptions, erythema nodosum, urticaria, Stevens-Jonson syndrome...
2015: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/26392747/acute-hemorrhagic-conjunctivitis-anti-coxsackievirus-a24-variant-secretory-immunoglobulin-a-in-acute-and-convalescent-tear
#8
Marlyn P Langford, Edwin A Anders, Maxwell A Burch
PURPOSE: The purpose of this paper is to present the clinical course of a laboratory-acquired case of acute hemorrhagic conjunctivitis (AHC) caused by coxsackievirus A24 variant (CA24v). Also, the anti-CA24v neutralizing activity and anti-CA24v immunoglobulin (Ig) G and secretory IgA (sIgA) in acute and convalescent tears and/or sera are presented. CASE: A 60-year-old male presented with acute-onset left eyelid edema, tearing, conjunctival erythema, pain, foreign body sensation, and subconjunctival hemorrhage 24 hours after suspected laboratory exposure...
2015: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26388283/etiology-and-outcome-of-crescentic-glomerulonephritis-from-a-single-center-in-china-a-10-year-review
#9
Shasha Chen, Zheng Tang, Haiyan Xiang, Xiaowei Li, Hao Chen, Haitao Zhang, Weixin Hu, Caihong Zeng, Zhihong Liu
BACKGROUND: The disease spectrum of crescentic glomerulonephritis (GN) has been described in only a few previous studies, and detailed epidemiologic data from China are unavailable to date. STUDY DESIGN: Case series. SETTING & PARTICIPANTS: 528 patients with biopsy-proven crescentic GN in 2003 to 2013 from a single center. PREDICTOR: Crescentic GN was classified into 3 types according to immunofluorescence findings: type I was defined as linear deposition of immunoglobulins along the glomerular basement membrane; type II, as glomerular deposition of immune complex; and type III, as pauci-immune deposition...
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26385602/association-of-complement-factor-b-allotypes-and-serum-biomarkers-in%C3%A2-rheumatoid-arthritis-patients-and-their-relatives
#10
F R Nass, T L Skare, I Goeldner, R Nisihara, I J Messias-Reason, S R R Utiyama
The aim of the study was to investigate the allotypic variability of complement factor B (BF) in patients and relatives with rheumatoid arthritis (RA) and its association with serological biomarkers and clinical features of the disease. BF allotypes were determined by high-voltage agarose gel electrophoresis in serum samples of 180 patients with RA, 198 relatives and 98 controls from Southern Brazil. Anticyclic citrullinated peptide (anti-CCP), antimutated citrullinated vimentin (anti-MCV) and IgA-rheumatoid factor (RF) were determined by ELISA and IgM-RF by latex agglutination in all samples...
December 2015: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/26383224/reduced-inf2-expression-in-nephrotic-syndrome-is-possibly-related-to-clinical-severity-of-steroid-resistance-in-children
#11
Hiroshi Tamura, Hitoshi Nakazato, Shohei Kuraoka, Kaori Yoneda, Wataru Takahashi, Fumio Endo
AIM: Mutations of the inverted formin 2 gene (INF2), which encodes a member of the formin family, cause autosomal dominant focal segmental glomerulosclerosis (FSGS) and Charcot-Marie-Tooth (CMT) disease-associated FSGS. However, their role in idiopathic FSGS remains unclear. This study investigated INF2 localization in the normal adult kidney and its expression in children with idiopathic nephrotic syndrome. METHODS: We generated a rabbit polyclonal antibody against the conjugated peptide from human INF2 and studied the glomerular expression of INF2 and synaptopodin using normal human adult kidney tissues and tissues from children with glomerular diseases such as minimal change disease (MCD), FSGS, IgA nephropathy (IgAN), non-IgA mesangial proliferative glomerulonephritis (non-IgAN), and Henoch-Schönlein purpura nephritis (HSPN)...
June 2016: Nephrology
https://www.readbyqxmd.com/read/26374753/prevalence-of-celiac-disease-in-adult-patients-with-iron-deficiency-anemia-of-obscure-origin-in-kashmir-india
#12
Gul Javid, Shaheen Nazir Lone, Abid Shoukat, Bashir Ahmed Khan, Gulam Nabi Yattoo, Altaf Shah, Jaswinder Singh Sodi, Mushtaq Ahmed Khan, Showkat Ali Zarger
OBJECTIVES: The purpose of this study was to evaluate the prevalence of celiac disease in adult patients with iron-deficiency anemia of obscure origin. METHODS: One hundred and sixty-one consecutive patients with iron-deficiency anemia of obscure origin were evaluated. Tissue transglutaminase antibodies levels were done and duodenal biopsies were scored according to Marsh classification. Diagnosis was based on positive IgA anti-tissue transglutaminase antibodies and abnormal histopathology...
July 2015: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/26373392/blastocystis-specific-serum-immunoglobulin-in-patients-with-irritable-bowel-syndrome-ibs-versus-healthy-controls
#13
Robyn Nagel, Rebecca J Traub, Marcella M S Kwan, Helle Bielefeldt-Ohmann
BACKGROUND: Blastocystis species are common enteric human parasites and carriage has been linked to Irritable Bowel Syndrome (IBS), particularly diarrhoea-predominant IBS. The spectrum of immune reactivity to Blastocystis proteins has been reported previously in symptomatic patients. We investigated differences in serum immunoglobulin profiles between patients with IBS, both positive and negative for Blastocystis carriage, and healthy controls (HC). METHODS: Forty diarrhoea-predominant IBS patients (26 patients positive for Blastocystis sp...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/26370865/aspirin-and-eicosapentaenoic-acid-may-arrest-progressive-iga-nephropathy-a-potential-alternative-to-immunosuppression
#14
Junichi Hirahashi, Norio Hanafusa, Takehiko Wada, Makoto Arita, Keiichi Hishikawa, Matsuhiko Hayashi, Masaomi Nangaku
Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA...
2015: Internal Medicine
https://www.readbyqxmd.com/read/26355295/inactivated-eyedrop-influenza-vaccine-adjuvanted-with-poly-i-c-is-safe-and-effective-for-inducing-protective-systemic-and-mucosal-immunity
#15
Eun-Do Kim, Soo Jung Han, Young-Ho Byun, Sang Chul Yoon, Kyoung Sub Choi, Baik Lin Seong, Kyoung Yul Seo
The eye route has been evaluated as an efficient vaccine delivery routes. However, in order to induce sufficient antibody production with inactivated vaccine, testing of the safety and efficacy of the use of inactivated antigen plus adjuvant is needed. Here, we assessed various types of adjuvants in eyedrop as an anti-influenza serum and mucosal Ab production-enhancer in BALB/c mice. Among the adjuvants, poly (I:C) showed as much enhancement in antigen-specific serum IgG and mucosal IgA antibody production as cholera toxin (CT) after vaccinations with trivalent hemagglutinin-subunits or split H1N1 vaccine antigen in mice...
2015: PloS One
https://www.readbyqxmd.com/read/26351932/diagnostic-and-clinical-significance-of-crohn-s-disease-specific-pancreatic-anti-gp2-and-anti-cuzd1-antibodies
#16
Polychronis Pavlidis, Lars Komorowski, Bianca Teegen, Christos Liaskos, Andreas L Koutsoumpas, Daniel S Smyk, Carlo Perricone, Maria G Mytilinaiou, Winfried Stocker, Alastair Forbes, Dimitrios P Bogdanos
BACKGROUND: Pancreatic autoantibodies (PAB) targeting GP2 and CUZD1 are Crohn's disease (CrD)-markers. The clinical significance of anti-GP2 antibodies has been assessed, but that of anti-CUZD1 remains elusive. The aim of the study was to assess the clinical utility of anti-CUZD1/anti-GP2 by novel cell-based indirect immunofluorescence (IIF) assays in CrD. METHODS: A total of 212 CrD and 249 UC patients followed up at a London IBD centre were investigated to simultaneously detect PABs, anti-GP2 and anti-CUZD1 by IIF using primate pancreatic tissue, and HEK293 over-expressing CUZD1 or GP2...
February 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/26348210/pathogenic-role-of-a-proliferation-inducing-ligand-april-in-murine-iga-nephropathy
#17
Yang Gyun Kim, Montserrat Alvarez, Hitoshi Suzuki, Sachiko Hirose, Shozo Izui, Yasuhiko Tomino, Bertrand Huard, Yusuke Suzuki
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor (TNF) superfamily. Despite advances in clinical and genetic studies, the details of the pathological roles of APRIL in IgA nephropathy (IgAN) remain to be fully defined. The present study aimed to further assess the pathological role of APRIL using a mouse model of IgAN. Mice with IgAN designated "grouped ddY" (gddY) were intraperitoneally administered an anti-APRIL monoclonal antibody (anti-APRIL Ab) or control IgG (Control Ab) twice each week for 2 weeks starting during the early stage of IgAN (6-7 weeks of age)...
2015: PloS One
https://www.readbyqxmd.com/read/26347586/a-subgroup-of-latently-mycobacterium-tuberculosis-infected-individuals-is-characterized-by-consistently-elevated-iga-responses-to-several-mycobacterial-antigens
#18
Ralf Baumann, Susanne Kaempfer, Novel N Chegou, Wulf Oehlmann, Ralf Spallek, André G Loxton, Paul D van Helden, Gillian F Black, Mahavir Singh, Gerhard Walzl
Elevated antibody responses to Mycobacterium tuberculosis antigens in individuals with latent infection (LTBI) have previously been linked to an increased risk for progression to active disease. Studies in the field focussed mainly on IgG antibodies. In the present study, IgA and/or IgG responses to the mycobacterial protein antigens AlaDH, NarL, 19 kDa, PstS3, and MPT83 were determined in a blinded fashion in sera from 53 LTBI controls, 14 healthy controls, and 42 active TB subjects. Among controls, we found that elevated IgA levels against all investigated antigens were not randomly distributed but concentrated on a subgroup of <30%-with particular high levels in a small subgroup of ~5% comprising one progressor to active TB...
2015: Mediators of Inflammation
https://www.readbyqxmd.com/read/26347238/collagenous-enterocolitis-manifesting-as-watery-diarrhoea-and-iron-deficiency-anaemia
#19
Alan Hoi Lun Yau, Wei Xiong, Hin Hin Ko
A 56-year-old Caucasian woman presented with epigastric pain, watery diarrhoea, bloating and flatulence following treatment with duloxetine and venlafaxine for anxiety and depression. Abdominal examination was benign. Blood work revealed haemoglobin of 96 g/L (115-160 g/L), iron 6 μmol/L (10-33 μmol/L), transferrin saturation 0.08 (0.20-0.55), ferritin 26 μg/L (15-180 μg/L), albumin 46 g/L (35-50 g/L), pre-albumin 293 mg/L (170-370 mg/L), total IgA 2.64 g/L (0.78-3.58 g/L) and anti-tTG IgA 5 units (<20 units)...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26339731/the-celiac-iceberg-from-the-clinical-spectrum-to-serology-and-histopathology-in-children-and-adolescents-with-type-1-diabetes-mellitus-and-down-syndrome
#20
Rosane Costa Gomes, Jussara Cerqueira Maia, Ricardo Fernando Arrais, Carlos André Nunes Jatobá, Maria Auxiliadora Carvalho Rocha, Maria Edinilma Felinto Brito, Ana Laissa Oliveira Nazion, Clarissa Marques Maranhão, Hélcio De Sousa Maranhão
OBJECTIVE: The objective of this study is to investigate the occurrence of gastrointestinal (GI) and extraintestinal symptoms in children and adolescents with type 1 diabetes mellitus (DM1) and Down syndrome (DS) and their association with specific antibodies and histopathology of celiac disease (CelD), representing its clinical forms in the iceberg. MATERIAL AND METHODS: Cross-sectional study (November 2009-December 2012) conducted at an outpatient care facility in Northeast Brazil including patients [DM1 (n = 111); DS (n = 77)] aged 10 months-18 years old...
2016: Scandinavian Journal of Gastroenterology
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