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JOURNAL ARTICLE
Birgit Arnholdt-Schmitt, Debabrata Sircar, Shahid Aziz, Thais Andrade Germano, Karine Leitão Lima Thiers, Carlos Noceda, Revuru Bharadwaj, Gunasekaran Mohanapriya, José Hélio Costa
Xylella fastidiosa ( Xf ) is a global bacterial threat for a diversity of plants, including olive trees. However, current understanding of host responses upon Xf -infection is limited to allow early disease prediction, diagnosis, and sustainable strategies for breeding on plant tolerance. Recently, we identified a ma jor c omplex t rait for e arly d e novo programming, named CoV-MAC-TED , by comparing early transcriptome data during plant cell survival with SARS-CoV-2-infected human cells. This trait linked ROS/RNS balancing during first hours of stress perception with increased aerobic fermentation connected to alpha-tubulin-based cell restructuration and control of cell cycle progression...
March 5, 2024: Pathogens
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JOURNAL ARTICLE
Nikolett Lupsa, Barbara Érsek, Csenge Böröczky, Dávid Kis, Eszter Szarka, Katalin Lumniczky, Géza Sáfrány, Zoltán S Zádori, Árpád Szöőr, Edit I Buzás, Zoltán Pós
This study sought to compare the behavior of Treg subsets displaying different coexpression patterns of Neuropilin-1 (Nrp1) and Helios, under the influence of gut stress unrelated to hematopoietic stem cell transplantation, pretransplantation conditioning, and posttransplant gastrointestinal acute graft versus host disease (GI-aGvHD). Host CD4+ /CD25hi /Foxp3+ Treg cells, identified by flow cytometry, were isolated from various tissues of mice affected by these stressors. Expression of CD25, CTLA-4, CD39, OX40, integrin-β7, LAG3, TGFβ/LAP, granzyme-A, -B, and interleukin-10 was compared in four Treg subsets displaying Helios or Nrp1 only, both or none...
March 26, 2024: European Journal of Immunology
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JOURNAL ARTICLE
Jerod L Ptacin, Lina Ma, Carolina E Caffaro, Nicole V Acuff, Kristine Germar, Peter Severy, Yanyan Qu, Jose-Luis Vela, Xinming Cai, Kristine M San Jose, Hans R Aerni, David B Chen, Ean Esche, Taylor K Ismaili, Rob Herman, Yelena Pavlova, Michael J Pena, Jasmine Nguyen, Lilia K Koriazova, Laura K Shawver, Ingrid B Joseph, Jill Mooney, Mark Peakman, Marcos E Milla
BACKGROUND: Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of autoimmune (AI) disorders yet exhibits short systemic half-life and opposing immune responses that negate an appropriate therapeutic index. METHODS: A semi-synthetic microbial technology platform was used to engineer a site-specifically pegylated form of rhIL-2 with enhanced PK, specificity for induction of immune-suppressive regulatory CD4 + T cells (Tregs), and reduced stimulation of off-target effector T and NK cells...
March 26, 2024: Commun Med (Lond)
#24
JOURNAL ARTICLE
Hélio Noberto de Araújo Júnior, Igor Renno Guimarães Lopes, Ana Caroline Freitas Caetano de Sousa, Gleidson Benevides de Oliveira, Radan Elvis Matias de Oliveira, Moisés Dantas Tertulino, Emanuel Lucas Bezerra Rocha, Paulo Ricardo Firmino, Alexsandra Fernandes Pereira, Moacir Franco de Oliveira
Given the importance of information on intrauterine development in diagnosing anomalies in the gestational development of the species for the development of assisted reproduction technologies as well as understanding the autonomy and responsiveness of the newborn, the aim of the present study was to describe the external morphology of collared peccary conceptuses. For this study, two conceptuses were used per gestational age of 25-120 days post-copulation (dpc) and neonates with 145 dpc, totalling 22 animals...
May 2024: Anatomia, Histologia, Embryologia
#25
JOURNAL ARTICLE
Chelisa Cardinez, Yuwei Hao, Kristy Kwong, Ainsley R Davies, Morgan B Downes, Nadia A Roberts, Jason D Price, Raquel A Hernandez, Jessica Lovell, Rochna Chand, Zhi-Ping Feng, Anselm Enders, Carola G Vinuesa, Bahar Miraghazadeh, Matthew C Cook
Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3+ regulatory T cells (Tregs). By contrast, we know very little about the consequences of defects that amplify aspects of Treg function or differentiation. Here we show that mice heterozygous for an Ikbkb gain-of-function mutation develop psoriasis. Doubling the gene dose (IkbkbGoF/GoF ) results in dactylitis, spondylitis, and characteristic nail changes, which are features of psoriatic arthritis. IkbkbGoF mice exhibit a selective expansion of Foxp3 + CD25+ Tregs of which a subset express IL-17...
March 25, 2024: Nature Communications
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JOURNAL ARTICLE
José Medina Pestana, Marina Pontello Cristelli, Helio Tedesco Silva
No abstract text is available yet for this article.
April 1, 2024: Transplantation
#27
JOURNAL ARTICLE
Mariana Castanheira, John H Kimbrough, Jill Lindley, Timothy B Doyle, Jessica M Ewald, Helio S Sader
We subjected seven P . aeruginosa isolates to a 10-day serial passaging against five antipseudomonal agents to evaluate resistance levels post-exposure and putative resistance mechanisms in terminal mutants were analyzed by whole-genome sequencing analysis. Meropenem (mean, 38-fold increase), cefepime (14.4-fold), and piperacillin-tazobactam (52.9-fold) terminal mutants displayed high minimum inhibitory concentration (MIC) values compared to those obtained after exposure to ceftolozane-tazobactam (11.4-fold) and ceftazidime-avibactam (5...
March 25, 2024: Antimicrobial Agents and Chemotherapy
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JOURNAL ARTICLE
Alice C Mosberger, Leslie J Sibener, Tiffany X Chen, Helio F M Rodrigues, Richard Hormigo, James N Ingram, Vivek R Athalye, Tanya Tabachnik, Daniel M Wolpert, James M Murray, Rui M Costa
The brain can generate actions, such as reaching to a target, using different movement strategies. We investigate how such strategies are learned in a task where perched head-fixed mice learn to reach to an invisible target area from a set start position using a joystick. This can be achieved by learning to move in a specific direction or to a specific endpoint location. As mice learn to reach the target, they refine their variable joystick trajectories into controlled reaches, which depend on the sensorimotor cortex...
March 21, 2024: Cell Reports
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JOURNAL ARTICLE
Marco Luigetti, Dianna Quan, John L Berk, Isabel Conceição, Yohei Misumi, Chi-Chao Chao, Shaun Bender, Emre Aldinc, John Vest, David Adams
INTRODUCTION: Hereditary transthyretin (ATTRv, v for variant) amyloidosis is a rare, progressive, fatal disease with multisystem manifestations, caused by pathogenic variants in the transthyretin (TTR) gene. Vutrisiran, an RNA interference therapeutic that results in rapid TTR knockdown, improved neuropathy and quality of life (QOL) versus external placebo in patients with ATTRv amyloidosis with polyneuropathy in the phase 3 HELIOS-A study (NCT03759379). This post hoc analysis evaluates the impact of baseline neuropathy severity on response to vutrisiran treatment...
March 21, 2024: Neurology and Therapy
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JOURNAL ARTICLE
Magdalena Serafin-Andrzejewska, Anna Jama-Rodzeńska, Waldemar Helios, Marcin Kozak, Sylwia Lewandowska, Dariusz Zalewski, Andrzej Kotecki
Soybean, belonging to legumes, has a specific ability to biological nitrogen fixation, which can be reinforced by seeds inoculation. However, support with a starter dose of mineral nitrogen fertilizer may be necessary to achieve high seed yields. A four-year field experiment was conducted to determine the effect of mineral N fertilization (0, 30, 60 kg ha-1 ), seed inoculation with two commercial inoculants and combinations of these treatments on yield components and yielding of soybean in conditions of south-western part of Poland...
March 20, 2024: Scientific Reports
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JOURNAL ARTICLE
Alexandre D Andrade, Priscila G C Almeida, Noemia A P Mariani, Natalia C M Santos, Isabela A Camargo, Poliana V Martini, Helio Kushima, Dingding Ai, Maria Christina W Avellar, Andreas Meinhardt, Christiane Pleuger, Erick J R Silva
BACKGROUND: Region-specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis in men. Toll-like receptors (TLRs) are essential to orchestrate immune responses against bacterial infections. The epididymis displays region-specific inflammatory responses to bacterial-derived TLR agonists, such as lipopolysaccharide (LPS; TLR4 agonist) and lipoteichoic acid (LTA; TLR2/TLR6 agonist), suggesting that TLR-associated signaling pathways could influence the magnitude of inflammatory responses in epididymitis...
March 18, 2024: Andrology
#32
REVIEW
Paulo Ricardo Criado, Mayra Ianhez, Roberta Fachini Jardim Criado, Juliana Nakano, Daniel Lorenzini, Hélio Amante Miot
Prurigo is a reactive, hyperplastic skin condition characterized by pruritic papules, plaques, and/or nodules. The temporal classification includes acute/subacute and chronic disease (≥ 6 weeks), with different clinical variants, synonymies, and underlying etiological factors. The immunology of chronic prurigo shows similarities with atopic dermatitis due to the involvement of IL-4 and IL-13, IL-22, and IL-31. Treatment includes antihistamines, topical steroids, dupilumab, and JAK inhibitors. Several conditions manifest clinically as prurigo-like lesions, and the correct clinical diagnosis must precede correct treatment...
March 16, 2024: Anais Brasileiros de Dermatologia
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REVIEW
Marina Vilela Estevam, Gilson Helio Toniollo, Maricy Apparicio
Congenital malformations can affect almost 7% of canine newborns. The increase of commercial dog breeding and inbreeding used to maintain the striking characteristics of each breed, the appearance of malformations has become increasingly common, especially in brachycephalic dogs. The causes are diverse, and include genetic, nutritional, iatrogenic, and infectious factors, often making it difficult to establish a cause-consequence relationship. The high mortality associated with malformations comes not only from the fact that some are incompatible with life, but also because even if many undergo surgical treatment or correction, they require specific management, monitoring, and clinical treatment for an indefinite period of time...
March 13, 2024: Research in Veterinary Science
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Luiz Eduardo Correia Miranda, Hélio Batista de Souza Junior, Matheus Stillner
No abstract text is available yet for this article.
March 15, 2024: ANZ Journal of Surgery
#35
JOURNAL ARTICLE
Olayinka Oluwaseun Oluwasina, Adedeji Adebukola Adelodun, Olugbenga Oludayo Oluwasina, Helio A Duarte, Sunday Joseph Olusegun
Positively charged contaminants can be strongly attracted by sulfanilic acid-functionalized graphene oxide. Here, sulfonated graphene oxide (GO-SO3 H) was synthesized and characterized for cationic crystal violet (CV) adsorption. We further studied the effect of pH, initial concentration, and temperature on CV uptake. The highest CV uptake occurred at pH 8. A kinetic study was also carried out by applying the pseudo-first-order and pseudo-second-order models. The pseudo-second-order's adsorption capacity (qe) value was much closer to the experimental qe (qeexp :0...
March 14, 2024: Scientific Reports
#36
JOURNAL ARTICLE
Josiane Garcia, Anna Cecília Dias Maciel Carneiro, Sheila Soares Silva, Karla Fabiana Nunes da Silva, Joilson Meneguci, Helio Moraes-Souza
BACKGROUND: Blood transfusion is an effective therapeutic practice. However, even adopting all procedures for transfusion safety, there are risks, one of which is immediate adverse reactions. The aim of this study was, by active search, to evaluate the occurrence of immediate adverse reactions estimating the occurrence rate within the first 24 h. METHODS: An exploratory, descriptive, prospective study with quantitative analysis was carried out of patients undergoing surgery who received blood component transfusions during hospitalization from October 2018 to August 2019...
February 29, 2024: Hematology, Transfusion and Cell Therapy
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JOURNAL ARTICLE
Nathalia Zini, Matheus Henrique Tavares Ávila, Natalia Morbi Cezarotti, Maisa Carla Pereira Parra, Cecília Artico Banho, Livia Sacchetto, Andreia Francesli Negri, Emerson Araújo, Cintia Bittar, Bruno Henrique Gonçalves de Aguiar Milhin, Victor Miranda Hernandes, Karina Rocha Dutra, Leonardo Agopian Trigo, Leonardo Cecílio da Rocha, Rafael Alves da Silva, Gislaine Celestino Dutra da Silva, Tamires Fernanda Pereira Dos Santos, Beatriz de Carvalho Marques, Andresa Lopes Dos Santos, Marcos Tayar Augusto, Natalia Franco Bueno Mistrão, Milene Rocha Ribeiro, Tauyne Menegaldo Pinheiro, Thayza Maria Izabel Lopes Dos Santos, Clarita Maria Secco Avilla, Victoria Bernardi, Caroline Freitas, Flora de Andrade Gandolfi, Hélio Correa Ferraz Júnior, Gabriela Camilotti Perim, Mirella Cezare Gomes, Pedro Henrique Carrilho Garcia, Rodrigo Sborghi Rocha, Tayna Manfrin Galvão, Eliane Aparecida Fávaro, Samuel Noah Scamardi, Karen Sanmartin Rogovski, Renan Luiz Peixoto, Luiza Benfatti, Leonardo Teixeira Cruz, Paula Patricia de Freitas Chama, Mânlio Tasso Oliveira, Aripuanã Sakurada Aranha Watanabe, Ana Carolina Bernardes Terzian, Alice de Freitas Versiani, Margareth Regina Dibo, Francisco Chiaravalotti-Neto, Scott Cameron Weaver, Cassia Fernanda Estofolete, Nikos Vasilakis, Mauricio Lacerda Nogueira
BACKGROUND: Chikungunya virus (CHIKV) has spread across Brazil with varying incidence rates depending on the affected areas. Due to cocirculation of arboviruses and overlapping disease symptoms, CHIKV infection may be underdiagnosed. To understand the lack of CHIKV epidemics in São José do Rio Preto (SJdRP), São Paulo (SP), Brazil, we evaluated viral circulation by investigating anti-CHIKV IgG seroconversion in a prospective study of asymptomatic individuals and detecting anti-CHIKV IgM in individuals suspected of dengue infection, as well as CHIKV presence in Aedes mosquitoes...
March 14, 2024: PLoS Neglected Tropical Diseases
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JOURNAL ARTICLE
Shang Li, Peng Zhang, Ao Li, Jiayu Bao, Zhiqiang Pan, Ying Jie
Penetrating keratoplasty remains the most common treatment to restore vision for corneal diseases. Immune rejection after corneal transplantation is one of the major causes of graft failure. In recent years, Rho-associated protein kinase (ROCK) inhibitors have been found to be associated with the activation of the STATs pathway and are widely studied in autoimmune diseases. Therefore, it may be possible that the ROCK inhibitors also participate in the local and systemic immune regulation in corneal transplantation through activation of the STATs pathway and affect the CD4+ T cell differentiation...
March 11, 2024: Experimental Eye Research
#39
JOURNAL ARTICLE
Jhony Robson de Oliveira, Aline Beatriz Mahler Pereira, Henrique Ismarsi de Souza, Wanessa Maria Dos Santos, Thaís Sorares Farnesi de Assunção, Fernanda Bernadelli de Vito, Helio Moraes de Souza, Paulo Roberto da Silva, Marcos Vinicius da Silva, Virmondes Rodrigues Junior, Alexandre de Paula Rogerio
Smoking causes several diseases such as chronic obstructive pulmonary disease (COPD). Aspirin-triggered-resolvin D1 (AT-RvD1) is a lipid mediator produced during the resolution of inflammation and demonstrates anti-inflammatory and pro-resolution effects in several inflammatory experimental models including in the airways. Here we evaluated the role of AT-RvD1 (100nM) in bronchial epithelial cells (BEAS-2B) stimulated by cigarette smoke extract (CSE; 1%; 1 cigarette) for 24h. CSE induced the productions of IL-1β, TNF-α, IL-10, IL-4 and IFN-γ as well as the activations of NF-κB and STAT3 and the expression of ALX/FPR2 receptor...
March 7, 2024: Prostaglandins & Other Lipid Mediators
#40
JOURNAL ARTICLE
Daniella Torres Tagawa, Angela Maria Borri Wolosker, Bruna Maluza Florez, Gladys Cristina Dominguez, Helio Kiitiro Yamashita, Luís Antônio de Arruda Aidar, Henrique Carrete Junior
OBJECTIVE: The objective of this prospective study was to assess possible changes in the position and shape of the temporomandibular joint (TMJ) articular disc in patients treated with two protocols of rapid maxillary expansion (RME) and face mask (FM) therapy. METHODS: A sample of 88 patients with Class III or Class III subdivision malocclusions, aged between 6 and 13 years, were consecutively selected and divided into three groups (G): G1-34 patients were treated with RME, followed by FM therapy; G2-34 patients were treated using RME according to modified alternate rapid maxillary expansion and constriction (ALT-RAMEC) protocol, followed by FM therapy...
March 8, 2024: Orthodontics & Craniofacial Research
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