Read by QxMD icon Read


Marcelo Arantes Levenhagen, Hélio Conte, Julia Maria Costa-Cruz
Strongyloides stercoralis is a helminth parasite that can infect millions of people worldwide, particularly in tropical, subtropical and temperate regions with poor sanitation. Several aspects of epidemiology, biology and host-parasite interactions of S. stercoralis have been studied, and substantial knowledge has been acquired; however, very few studies on immunotherapeutic control strategies to prevent infection and disease in humans have been conducted. Therefore, this article reviews the current progress and targets toward vaccine and passive immunization approaches for Strongyloides spp...
October 18, 2016: Immunology Letters
Hélio A G Teive, Adriana Moro, Walter O Arruda, Salmo Raskin, Gladys M G Teive, Norberto Dalabrida, Renato P Munhoz
The authors present a historical review of spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD), the most common form of spinocerebellar ataxia in Brazil, and consider the high frequency of cases in families from Itajaí, a city on the coast of the state of Santa Catarina with a large population of Portuguese/Azorean descent.
October 2016: Arquivos de Neuro-psiquiatria
Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
Danielle Macedo, Adriano José Maia Chaves Filho, Caren Nádia Soares de Sousa, João Quevedo, Tatiana Barichello, Hélio Vitoriano Nobre Júnior, David Freitas de Lucena
OBJECTIVES: The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this narrative review is to compile the available studies regarding the influences of gut microbiota in behavior and depression and to show the antimicrobial effect of antidepressant drugs...
September 28, 2016: Journal of Affective Disorders
M Daves, J Blecken, T Matthias, A Frey, V Perkmann, A Dall Acqua, A Joos, S Platzgummer
The IIF using the HEp-2 cell substrate should be still considered the "gold standard" techniques for determination of antinuclear antibody (ANA). Standardization and automation can be considered to be still in progress. Aim of this study was to evaluate the performance of the commercially automated indirect immunofluorescent antinuclear HEp-2 antibody assay. The study was designed to compare two commercially available HEp-2 ANA by indirect immunofluorescent antibody assays using a sensitivity panel (120 clinically determined patients) and a specificity panel consisting of 78 clinically confirmed negative patients...
October 14, 2016: Immunologic Research
Maurício Galantier
No abstract text is available yet for this article.
May 2016: Brazilian Journal of Cardiovascular Surgery
Fabian Sanchis-Gomar, Helios Pareja Galeano, Jose A Rodriguez-Marroyo, Jos J de Koning, Alejandro Lucia, Carl Foster
Despite some advances, how the millions of variations in the human genome influence athletic performance (especially in endurance events) remains largely unknown, and no single genetic test can really predict sports talent. However, there is experimental evidence coming from animal research that selecting for even a simple characteristic like running ability, can produce comparatively large and rapid changes in performance. That such selection has not been specifically documented in humans is more evidence of the limits of physiology-archeology than of the unlikelihood of selection for physical abilities...
October 13, 2016: International Journal of Sports Physiology and Performance
Eric Segal, Helio Pedro, Karen Valdez-Gonzalez, Sarah Parisotto, Felicia Gliksman, Stephen Thompson, Jomard Sabri, Evan Fertig
BACKGROUND: When no chromosomal variations are identified, patients with suspected genetic etiologies can be tested using next-generation sequencing utilizing epilepsy panels. The primary objective of this study was to analyze the diagnostic yield of next-generation sequencing epilepsy panels in medication-resistant epilepsy subjects with non-clinically significant comparative genomic hybridization microarray results. METHODS: We completed a single-center retrospective review of the diagnostic yield of next-generation sequencing epilepsy panels in medication-resistant epilepsy subjects aged 18 years or less who had non-clinically significant comparative genomic hybridization microarray results from January 2011 to December 2014...
July 1, 2016: Pediatric Neurology
Peter B Winter, Renee M Brielmann, Nicholas P Timkovich, Helio T Navarro, Andreia Teixeira-Castro, Richard I Morimoto, Luis A N Amaral
The study of C. elegans has led to ground-breaking discoveries in gene-function, neuronal circuits, and physiological responses. Subtle behavioral phenotypes, however, are often difficult to measure reproducibly. We have developed an experimental and computational infrastructure to simultaneously record and analyze the physical characteristics, movement, and social behaviors of dozens of interacting free-moving nematodes. Our algorithm implements a directed acyclic network that reconstructs the complex behavioral trajectories generated by individual C...
October 11, 2016: Scientific Reports
Sergey N Samsonov, Veronika I Manykina, Natalia G Kleimenova, Svetlana S Parshina, Alena A Strekalovskaya, Palmira G Petrova
INTRODUCTION: cardiovascular impairment remains one of the most current problems of today's life and the definition of the connection between its development and the state of heliogeophysical storminess is currently important. The results of long-term researches of communication between cardiovascular catastrophes (myocardial infarction) and heliogeophysical storminess in the middle and high latitudes are shown in this work. AIM: to study the influence of space weather parameters on human cardio-vascular system in the high and middle latitudes...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Suellen da Silva Maciel, Magda Feres, Tiago Eduardo Dias Gonçalves, Glaucia Santos Zimmermann, Hélio Doyle Pereira da Silva, Luciene Cristina Figueiredo, Poliana Mendes Duarte
AIM: To evaluate whether obesity affects the subgingival microbial composition of patients with periodontal health or chronic periodontitis (CP). MATERIALS AND METHODS: Based on periodontal parameters, body mass index and waist-hip ratio, 166 patients were allocated into one of the following groups: Normal weight (NW) patients with periodontal health (n=44), NW patients with CP (n=40), Obese patients with periodontal health (n=40) and obese patients with CP (n=42)...
October 7, 2016: Journal of Clinical Periodontology
Gustavo José Luvizutto, Gabriela Rizzo Soares Rizzati, Marcelo Ortolani Fogaroli, Rodrigo Thomazi Rodrigues, Priscila Watson Ribeiro, Hélio Rubens de Carvalho Nunes, Gabriel Pereira Braga, Rafael Dalle Molle da Costa, Silméia Garcia Zanati Bazan, Luiz Antônio de Lima Resende, Adriana Bastos Conforto, Rodrigo Bazan
BACKGROUND: Unilateral spatial neglect (USN) is characterized by the inability to report or respond to people or objects that are presented in the spatial hemisphere that is contralateral to the lesioned hemisphere of the brain. USN has been associated with poor functional outcomes and long stays in hospitals and rehabilitation centers. Noninvasive brain stimulation, such as transcranial direct current stimulation (tDCS), has been used in people who have been affected by USN after stroke...
October 3, 2016: Trials
Carson Wiethan, Steffany Z Franceschini, Helio G Bonacorso, Mark Stradiotto
An efficient one-pot transition metal-free procedure for the synthesis of new pyrazolo[1,5-a]quinoxalin-4(5H)-ones from easily prepared 1-(2-chlorophenyl-5-ethylcarboxylate)pyrazoles and various primary alkylamines is described. The key steps involved in the synthesis of the new 5,6-fused ring system are the formation of an amide intermediate followed by an intramolecular N-arylation reaction via nucleophilic aromatic substitution.
September 21, 2016: Organic & Biomolecular Chemistry
Ana J Abascal, Sonia Castanedo, Paula Núñez, Adam Mellor, Annika Clements, Beatriz Pérez, Mar Cárdenas, Helios Chiri, Raúl Medina
This paper presents a high-resolution operational forecast system for providing support to oil spill response in Belfast Lough. The system comprises an operational oceanographic module coupled to an oil spill forecast module that is integrated in a user-friendly web application. The oceanographic module is based on Delft3D model which uses daily boundary conditions and meteorological forcing obtained from COPERNICUS and from the UK Meteorological Office. Downscaled currents and meteorological forecasts are used to provide short-term oil spill fate and trajectory predictions at local scales...
October 3, 2016: Marine Pollution Bulletin
Gustavo José Luvizutto, Marcelo Fernando Zeugner Bertotti, Thiago Dias Fernandes, Hélio Rubens de Carvalho Nunes, Gabriel Pereira Braga, Rodrigo Bazan, Luiz Antônio de Lima Resende
Objective: To relate F-waves with clinical and laboratory exams in the acute phase of stroke. Methods: Inclusion criteria for this cross-sectional study were: hemiplegia, absence of previous cranial trauma, myopathy, diabetes, alcoholism or other known causes of peripheral neuropathy, and normal sensory and motor conduction. The National Institutes of Health Stroke Scale (NIHSS) score, glycemia, glucosilate hemoglobin, and CPK were obtained at admission by routine blood exams...
September 2016: Arquivos de Neuro-psiquiatria
Hélio Manhica, Anna-Clara Hollander, Ylva B Almquist, Mikael Rostila, Anders Hjern
BACKGROUND: Migrants' socioeconomic adversity has been linked to schizophrenia. AIMS: To investigate whether the more favourable socioeconomic situation of adoptees prevents them from the high risk of schizophrenia found in other migrants. METHOD: Register study in a cohort of refugees and inter-country adoptees aged 16-40 years, born in East Africa (n=8389), Latin America (n=11 572) and 1.2 million native Swedes. Cox-regression models estimated hazard ratios (HRs) of schizophrenia in data from psychiatric care...
January 2016: BJPsych Open
Illymack Cf de Araújo, Elenice Defune, Luciana Pf Abbade, Hélio A Miot, Matheus Bertanha, Lídia R de Carvalho, Rosana R Ferreira, Winston B Yoshida
OBJECTIVES: Compare the efficacy and safety of fibrin gel to 8% papain gel for wound dressing of venous ulcers. METHOD: Patients with chronic venous ulcers were randomly assigned to one in three groups: Group 1-fibrin gel; Group 2-8% papain gel; Group 3-carbopol gel (control). Patients were seen every 15 days during 2 months, verifying reduction of the ulcer area, local infection, exudation, and epithelization. All serious or nonserious adverse events were recorded...
October 4, 2016: Phlebology
Han Xie, Melissa Chua, Intekhab Islam, Ricardo Bentini, Tong Cao, José Carlos Viana-Gomes, Antônio Hélio Castro Neto, Vinicius Rosa
OBJECTIVE: The objective was to investigate the potential of graphene (Gp) to induce odontogenic and osteogenic differentiation in dental pulp stem cells (DPSC). METHODS: Gp was produced by chemical vapor deposition. DPSC were seeded on Gp or glass (Gl). Cells were maintained in culture medium for 28 days. Every two days, culture medium from Gp was used to treat cells on Gl and vice versa. Mineralization and differentiation of DPSC on all substrates were evaluated after 14 and 28 days by alizarin red S staining, qPCR, immunofluorescence and FACS...
September 27, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Melissa Barreto Falcao, Sergio Cimerman, Kleber Giovanni Luz, Alberto Chebabo, Helena Andrade Brigido, Iza Maria Lobo, Artur Timerman, Rodrigo Nogueira Angerami, Clovis Arns da Cunha, Helio Arthur Bacha, Jesse Reis Alves, Alexandre Naime Barbosa, Ralcyon Francis Teixeira, Leonardo Weissmann, Priscila Rosalba Oliveira, Marco Antonio Cyrillo, Antonio Carlos Bandeira
A panel of national experts was convened by the Brazilian Infectious Diseases Society in order to organize the national recommendations for the management of zika virus infection. The focus of this document is the diagnosis, both clinical and laboratorial, and appropriate treatment of the diverse manifestations of this infection, ranging from acute mild disease to Guillain-Barré syndrome and also microcephaly and congenital malformations.
September 29, 2016: Annals of Clinical Microbiology and Antimicrobials
Olívia G S Araújo, Célio F B Haddad, Hélio R DA Silva, Lourdes A Pugener
Pipa is a Neotropical genus of frogs that dwell in freshwater environments. It includes four species that lack free-swimming larvae (P. aspera, P. arrabali, P. pipa, and P. snethlageae) and three with tadpoles (P. carvalhoi, P. myersi, and P. parva). Developmental tables such as the one proposed by Nieuwkoop and Faber might be useful for Pipa species with tadpoles. However, for the other Pipa species, to determine stages by this table or by any of the tables already prepared for frogs without tadpoles (e.g...
September 22, 2016: Anais da Academia Brasileira de Ciências
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"