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https://www.readbyqxmd.com/read/28817229/performance-equivalency-between-computer-based-and-traditional-pen-and-paper-assessment-a-case-study-in-clinical-anatomy
#1
Bruno Guimarães, José Ribeiro, Bernardo Cruz, André Ferreira, Hélio Alves, Ricardo Cruz-Correia, Maria Dulce Madeira, Maria Amélia Ferreira
The time, material, and staff-consuming nature of anatomy's traditional pen-and-paper assessment system, the increase in the number of students enrolling in medical schools and the ever-escalating workload of academic staff have made the use of computer-based assessment (CBA) an attractive proposition. To understand the impact of such shift in the assessment method, an experimental study evaluating its effect on students' performance was designed. Additionally, students' opinions toward CBA were gathered. Second-year medical students attending a Clinical Anatomy course were randomized by clusters in two groups...
August 17, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28813088/cognitive-dysfunction-in-corticobasal-degeneration
#2
Laís Machado de Oliveira, Igor Barcellos, Hélio A G Teive, Renato Puppi Munhoz
Corticobasal degeneration (CBD) was originally described as a distinct clinicopathological entity in 1967. Since then, different phenotypic presentations have emerged as possible manifestations of CBD histopathological findings. In addition, pathophysiological findings and the molecular basis have been delineated and several aspects of its cognitive manifestations have been clarified. Thus, not only the spectrum of what is currently designated as CBD has expanded, but overlap with other degenerative and even secondary disorders has made clinical diagnostic certainty even more challenging in the absence of specific and readily-available markers...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28813078/quality-of-life-in-parkinson-s-disease-patients-progression-markers-of-mild-to-moderate-stages
#3
Raissa Carla Moreira, Marise Bueno Zonta, Ana Paula Serra de Araújo, Vera Lúcia Israel, Hélio A G Teive
Objective: To investigate which factors are associated with the quality of life decline in Parkinson's disease patients from mild to moderate stages. Methods: The Unified Parkinson's Disease Rating Scale and Parkinson's Disease Questionnaire-39 were used to evaluate clinical/functional data and the quality of life. Results: The markers of clinical/functional worsening were drooling (p < 0.004), need for assistance with hygiene (p = 0.02), greater freezing frequency (p = 0...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28805497/putative-role-of-glutamine-in-the-activation-of-cbl-cipk-signalling-pathways-during-salt-stress-in-sorghum
#4
Rafael de Souza Miranda, Juan Carlos Alvarez-Pizarro, José Hélio Costa, Stelamaris de Oliveira Paula, José Tarquinio Prisco, Enéas Gomes-Filho
The salt overly sensitive (SOS) pathway is the only mechanism known for Na(+) extrusion in plant cells. SOS pathway activation involves Ca(2+)-sensing proteins, such as calcineurin B-like (CBL) proteins, and CBL-interacting protein kinases (CIPKs). In this signalling mechanism, a transit increase in cytosolic Ca(2+) concentration triggered by Na(+) accumulation is perceived by CBL (also known as SOS3). Afterward, SOS3 physically interacts with a CIPK (also known as SOS2), forming the SOS2/SOS3 complex, which can regulate the number downstream targets, controlling ionic homeostasis...
August 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28802917/aerobic-exercise-in-adolescence-results-in-an-increase-of-neuronal-and-non-neuronal-cells-and-in-mtor-overexpression-in-the-cerebral-cortex-of-rats
#5
Angélica Begatti Victorino, Fernando Tadeu Serra, Pâmella Pimentel Piñero, Alexandre Aparecido de Almeida, Glauber Menezes Lopim, Ivair Matias Junior, Helio Rubens Machado, Roberto Lent, Francisco Romero Cabral, Fernando Gomez-Pinilla, Ricardo Mario Arida, Sérgio Gomes da Silva
Better cognitive performance and greater cortical and hippocampal volume have been observed in individuals who undertook aerobic exercise during childhood and adolescence. One possible explanation for these beneficial effects is that juvenile physical exercise enables better neural development and hence more cells and neuronal circuitries. It is probable that such effects occur through intracellular signaling proteins associated with cell growth, proliferation and survival. Based on this information, we evaluated the number of neuronal and non-neuronal cells using isotropic fractionation and the expression and activation of intracellular proteins (ERK, CREB Akt, mTOR and p70S6K) in the cerebral cortex and hippocampal formation of the rats submitted to a physical exercise program on a treadmill during adolescence...
August 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28799955/a-serotonergic-deficit-in-the-dorsal-periaqueductal-gray-matter-may-underpin-enhanced-panic-like-behavior-in-diabetic-rats
#6
Eder Gambeta, Caio C Sestile, Manoela V Fogaça, Francisco S Guimarães, Elisabeth A Audi, Joice M da Cunha, Hélio Zangrossi, Paula Shimene de Melo Yamashita, Janaina M Zanoveli
It is known that diabetic (DBT) animals present dysregulation on the serotonergic system in several brain areas associated with anxiety-like responses. The aim of this study was to investigate the involvement of 5-HT1A receptors on dorsal periaqueductal gray (dPAG) in the behavioral response related to panic disorder in type-1 DBT animals. For this, the escape response by electric stimulation (ES) of dPAG in DBT and normoglycemic (NGL) animals was assessed. Both NGL and DBT animals were exposed to an open-field test (OFT) 28 days after DBT confirmation...
August 9, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28798500/studying-the-effects-of-two-various-methods-of-composting-on-the-degradation-levels-of-polycyclic-aromatic-hydrocarbons-pahs-in-sewage-sludge
#7
Joanna Poluszyńska, Elżbieta Jarosz-Krzemińska, Edeltrauda Helios-Rybicka
The research comprised of studying the effect composting sewage sludge with sawdust and vermicomposting with earthworm Eisenia fetida has on the degradation of 16 polycyclic aromatic hydrocarbons (PAHs). Raw rural sewage sludge prior composting was more contaminated with PAHs than urban sewage sludge, in both cases exceeding EU cutoff limits of 6 mg/kg established for land application. Dibenzo[a,h]anthracene (DBahAnt), acenaphtylene (Acy) and indeno[1,2,3-c,d]pyrene (IPyr) were predominant in rural sewage sludge, whilst the urban sewage sludge contained the highest concentrations of benzo[b]fluoranthene (BbFl), benzo[k]fluoranthene (BkFl) and indeno[1,2,3-c,d]pyrene (IPyr)...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28797641/b2-kinin-receptors-in-the-dorsal-periaqueductal-gray-are-implicated-in-the-panicolytic-like-effect-of-opiorphin
#8
Caio César Sestile, Jhonatan Christian Maraschin, Marcel Pereira Rangel, Rosangela Getirana Santana, Hélio Zangrossi, Frederico Guilherme Graeff, Elisabeth Aparecida Audi
Reported results have shown that the pentapeptide opiorphin inhibits oligopeptidases that degrade brain neuropeptides, and has analgesic and antidepressant effects in experimental animals, without either tolerance or dependency after chronic administration. In a previous study we showed that opiorphin has a panicolytic-like effect in the dorsal periaqueductal gray (dPAG) electrical stimulation test (EST), mediated by the μ-opioid receptor (MOR). This study further analyzes the mechanism of opiorphin panicolytic action, using the EST and drug injection inside the dPAG...
August 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28794180/determination-of-disk-diffusion-and-mic-quality-control-guidelines-for-high-dose-cefepime-tazobactam-wck-4282-a-novel-antibacterial-combination-consisting-of-a-%C3%AE-lactamase-inhibitor-and-a-fourth-generation-cephalosporin
#9
Stefan Riedel, Michael D Huband, Helio S Sader, Robert K Flamm, Ronald N Jones
High-dose cefepime-tazobactam (1:1; WCK 4282), a novel antibacterial combination consisting of the β-lactamase inhibitor tazobactam and a fourth-generation cephalosporin, is under clinical development for the therapy of serious gram-negative infections. A quality control (QC) study was performed to establish disk diffusion and MIC ranges for cefepime-tazobactam for multiple QC reference strains. The cefepime-tazobactam QC ranges for MIC (tazobactam at fixed 8 μg/mL) and disk diffusion (30/20-μg disk) test methods were approved by the CLSI Subcommittee on Antimicrobial Susceptibility Testing in January 2015 and January 2016...
August 9, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28793043/unintentional-pediatric-injuries-in-s%C3%A3-o-paulo-how-often-is-it-severe
#10
Simone de Campos Vieira Abib, Alessandra Mara Françóia, Renata Waksman, Maria Inês Dolci, Hélio Penna Guimarães, Frederico Moreira, Marcus Vinícius BoarettoCezillo, Adenauer Marinho Góes
Purpose: To evaluate severity and built a pilot of a national databank about pediatric trauma and to determine its severity. Methods: Prospective study of unintentional pediatric trauma in five hospitals in the city of São Paulo, Brazil. Results: 916 patients in 4 months. 61.5% of traumatized children were male, average 6.5 years. 48. 4% were falls. Most families had an average monthly income less than three minimum wages. 42% of accidents occurred at home...
July 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28792984/diretriz-da-sociedade-brasileira-de-cardiologia-e-da-sociedade-brasileira-de-hemodin%C3%A3-mica-e-cardiologia-intervencionista-sobre-interven%C3%A3-%C3%A3-o-coron%C3%A3-ria-percut%C3%A3-nea
#11
Fausto Feres, Ricardo A Costa, Dimytri Siqueira, J Ribamar Costa, Daniel Chamié, Rodolfo Staico, Áurea J Chaves, Alexandre Abizaid, José Antônio Marin-Neto, Anis Rassi, Roberto Botelho, Cláudia Maria Rodrigues Alves, Jamil Abdalla Saad, José A Mangione, Pedro A Lemos, Alexandre S Quadros, Marcelo A Cartaxo Queiroga, Marcelo J C Cantarelli, Hélio Roque Figueira
No abstract text is available yet for this article.
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28789620/hospital-admissions-due-to-alcohol-related-disorders-among-young-adult-refugees-who-arrived-in-sweden-as-teenagers-a-national-cohort-study
#12
Hélio Manhica, Karl Gauffin, Ylva B Almquist, Mikael Rostila, Lisa Berg, Ainhoa Rodríguez García de Cortázar, Anders Hjern
BACKGROUND: Psychological distress and lack of family support may explain the mental health problems that are consistently found in young unaccompanied refugees in Western countries. Given the strong relationship between poor mental health and alcohol misuse, this study investigated hospital admissions due to alcohol related disorders among accompanied and unaccompanied young refugees who settled in Sweden as teenagers. METHODS: The dataset used in this study was derived from a combination of different registers...
August 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28783828/is-weekend-only-physical-activity-enough-to-compensate-for-a-sedentary-lifestyle
#13
Alejandro Santos-Lozano, Helios Pareja-Galeano, Alejandro Lucia
No abstract text is available yet for this article.
August 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28757397/low-utility-of-serum-25-hydroxyvitamin-d3-and-1-25-dihydroxyvitamin-d3-in-predicting-peripheral-treg-and-th17-cell-counts-in-esrd-and-renal-transplant-patients
#14
Mostafa G Aly, Li Zhu, Rolf Weimer, Gerhard Opelz, Christian Morath, Ruben Kuon, Mohammed Tohamy, Gamal Saadi, Mona Soliman, Walaa Ibrahim, Volker Daniel
BACKGROUND: Vitamin D has shown an immune-modulatory effect in different studies. Vitamin D stimulates Tregs and inhibits Th17 cells. The immune-modulatory role of vitamin D in chronic kidney disease (CKD) and renal transplant patients is unclear. We measured whether different serum levels of vitamin D were associated with an increased or decreased presence of lymphocyte subsets including Treg and Th17 cells in end-stage renal disease (ESRD) and renal transplant recipients. METHODS: Eighty-seven renal transplant recipients and 53 end-stage renal disease (ESRD) patients were enrolled in this study...
July 27, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28751990/dermal-substitutes-use-in-reconstructive-surgery-for-skin-tumors-a-single-center-experience
#15
Mariane Campagnari, Andrea S Jafelicci, Helio A Carneiro, Eduard R Brechtbühl, Eduardo Bertolli, João P Duprat Neto
Reconstructive surgery following skin tumor resection can be challenging. Treatment options after removing the tumor are skin grafting, local pedicled and axial flaps, or microsurgery for complex and extensive wounds correction. Recently, the use of dermal substitutes has been extended to reconstructive surgery in cutaneous oncology. Objectives. To report both a single-center experience using dermal substitutes in reconstructive surgery for skin malignancies and reconstructive surgery's outcomes. Methods and Results...
2017: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28747257/cells-with-treg-specific-foxp3-demethylation-but-low-cd25-are-prevalent-in-autoimmunity
#16
Ricardo C Ferreira, Henry Z Simons, Whitney S Thompson, Daniel B Rainbow, Xin Yang, Antony J Cutler, Joao Oliveira, Xaquin Castro Dopico, Deborah J Smyth, Natalia Savinykh, Meghavi Mashar, Tim J Vyse, David B Dunger, Helen Baxendale, Anita Chandra, Chris Wallace, John A Todd, Linda S Wicker, Marcin L Pekalski
Identification of alterations in the cellular composition of the human immune system is key to understanding the autoimmune process. Recently, a subset of FOXP3(+) cells with low CD25 expression was found to be increased in peripheral blood from systemic lupus erythematosus (SLE) patients, although its functional significance remains controversial. Here we find in comparisons with healthy donors that the frequency of FOXP3(+) cells within CD127(low)CD25(low) CD4(+) T cells (here defined as CD25(low)FOXP3(+) T cells) is increased in patients affected by autoimmune disease of varying severity, from combined immunodeficiency with active autoimmunity, SLE to type 1 diabetes...
July 23, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28744114/acute-effects-of-power-and-resistance-exercises-on-hemodynamic-measurements-of-older-women
#17
Hélio José Coelho-Júnior, Maria-Cláudia Irigoyen, Samuel da Silva Aguiar, Ivan de Oliveira Gonçalves, Niels Olsen Saraiva Câmara, Marco Antonio Cenedeze, Ricardo Yukio Asano, Bruno Rodrigues, Marco Carlos Uchida
PURPOSE: The purpose of this study was to compare the acute effects of resistance training (RT) and power training (PT) on the hemodynamic parameters and nitric oxide (NO) bioavailability of older women. MATERIALS AND METHODS: A randomized experimental design was used in this study. Twenty-one older women (age: 67.1±4.6 years; body mass index: 28.03±4.9 kg/m(2); systolic blood pressure: 135.1±21.1 mmHg) were recruited to participate in this study. Volunteers were randomly allocated into PT, RT, and control session (CS) groups...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28740186/carotid-sinus-nerve-electrical-stimulation-in-conscious-rats-attenuates-systemic-inflammation-via-chemoreceptor-activation
#18
Fernanda Machado Santos-Almeida, Gean Domingos-Souza, César A Meschiari, Laura Campos Fávaro, Christiane Becari, Jaci A Castania, Alexandre Lopes, Thiago M Cunha, Davi J A Moraes, Fernando Q Cunha, Luis Ulloa, Alexandre Kanashiro, Geisa C S V Tezini, Helio C Salgado
Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1β (IL-1β) and interleukin 6 (IL-6)...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28735053/activity-of-dalbavancin-tested-against-gram-positive-clinical-isolates-causing-skin-and-skin-structure-infections-in-paediatric-patients-from-us-hospitals-2014-2015
#19
Michael A Pfaller, Rodrigo E Mendes, Helio S Sader, Mariana Castanheira, Robert K Flamm
OBJECTIVES: This study provides an in vitro analysis of dalbavancin activity against isolates causing skin and skin structure infections (SSSIs) in children. METHODS: 770 Staphylococcus aureus, 167 β-hemolytic streptococci (BHS), 42 coagulase-negative staphylococci (CoNS), 25 Enterococcus faecalis and 13 viridans group streptococci (VGS) were collected from children (<18 y/o) in the United States (2014-2015). RESULTS: Dalbavancin had MIC50/90 values of 0...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28735051/telavancin-activity-in-vitro-tested-against-a-worldwide-collection-of-gram-positive-clinical-isolates-2014
#20
Leonard R Duncan, Helio S Sader, Jennifer I Smart, Robert K Flamm, Rodrigo E Mendes
OBJECTIVES: Telavancin activity was measured against Gram-positive pathogens collected worldwide during 2014 using the revised broth microdilution testing method. The results were compared with previous reports. METHODS: A total of 10 552 isolates from 86 sites located in 32 countries were included as part of the Telavancin International Surveillance Program for the Americas, Europe and Asia-Pacific. RESULTS: Telavancin had MIC50 and MIC90 values of 0...
July 19, 2017: Journal of Global Antimicrobial Resistance
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