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https://www.readbyqxmd.com/read/27919205/achieving-simplified-disease-activity-index-remission-in-patients-with-active-rheumatoid-arthritis-is-associated-with-subsequent-good-functional-and-structural-outcomes-in-a-real-world-clinical-setting-under-a-treat-to-target-strategy
#1
Fumio Hirano, Waka Yokoyama, Hayato Yamazaki, Koichi Amano, Atsushi Kawakami, Taichi Hayashi, Naoto Tamura, Shinsuke Yasuda, Hiroaki Dobashi, Takao Fujii, Satoshi Ito, Yuko Kaneko, Toshihiro Matsui, Yasuaki Okuda, Kazuyoshi Saito, Fumihito Suzuki, Ryusuke Yoshimi, Ryoko Sakai, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai
OBJECTIVE: To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T). METHODS: In this multicentre, prospective cohort study, T2T was implemented in rheumatoid arthritis patients with moderate-to-high disease activity. SDAI or clinical disease activity index was assessed every 12 weeks, and treatment was adjusted to achieve clinical remission or low disease activity...
December 6, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27890439/a-japanese-nationwide-multicenter-survey-on-perioperative-complications-of-corrective-fusion-for-elderly-patients-with-adult-spinal-deformity
#2
Yu Yamato, Yukihiro Matsuyama, Kazuhiro Hasegawa, Yoichi Aota, Tsutomu Akazawa, Takahiro Iida, Kazumasa Ueyama, Koki Uno, Tokumi Kanemura, Noriaki Kawakami, Toshiaki Kotani, Masashi Takaso, Jun Takahashi, Masato Tanaka, Hiroshi Taneichi, Taichi Tsuji, Hideo Hosoe, Joji Mochida, Takachika Shimizu, Ikuho Yonezawa, Kota Watanabe, Morio Matsumoto
BACKGROUND: Recently, corrective fusion surgery for patients with adult spinal deformity (ASD) has become common in Japan. This study aimed to clarify the status of surgeries for ASD in Japan, focusing on perioperative complications. A nationwide multicenter survey gathering information on surgically treated ASD patients was conducted by the committee for Adult Spinal Deformity of the Japanese Scoliosis Society. METHODS: This study was a review of retrospectively collected data from 18 spine scoliosis centers belonging to the Japanese Scoliosis Society...
November 24, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27876317/discovery-of-soat2-inhibitors-from-synthetic-small-molecules
#3
Keisuke Kobayashi, Taichi Ohshiro, Hiroshi Tomoda, Feng Yin, Hai-Lei Cui, Pandurang V Chouthaiwale, Fujie Tanaka
Synthesis of new functionalized molecules and identification of biofunctional molecules can lead to the development of therapeutic leads and molecular tools for biomedical research. We have recently reported oxa-hetero-Diels-Alder reactions of enones with isatins to provide functionalized spirooxindole tetrahydropyran derivatives. Twenty-one compounds from the spirooxindole tetrahydropyran derivatives and related molecules were screened for inhibition of sterol O-acyltransferase (SOAT) isozymes SOAT1 and SOAT2...
December 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27863453/a-new-class-of-hepatitis-b-and-d-virus-entry-inhibitors-proanthocyanidin-and-its-analogs-that-directly-act-on-the-viral-large-surface-proteins
#4
Senko Tsukuda, Koichi Watashi, Taichi Hojima, Masanori Isogawa, Masashi Iwamoto, Katsumi Omagari, Ryosuke Suzuki, Hideki Aizaki, Soichi Kojima, Masaya Sugiyama, Akiko Saito, Yasuhito Tanaka, Masashi Mizokami, Camille Sureau, Takaji Wakita
: Introduction of direct acting antivirals against hepatitis C virus (HCV) has provided a revolutionary improvement in the treatment outcome. In contrast to HCV, however, the strategy for developing new antiviral agents against hepatitis B virus (HBV), especially viral-targeting compounds, is limited since HBV requires only four viral genes for its efficient replication/infection. Here, we identify an oligomeric flavonoid, proanthocyanidin (PAC) and its analogs, which inhibit HBV entry into host cells by targeting the HBV large surface protein (LHBs)...
November 18, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27862390/stacked-layer-heterostructure-films-of-2d-thiophene-nanosheets-and-graphene-for-high-rate-all-solid-state-pseudocapacitors-with-enhanced-volumetric-capacitance
#5
Zhong-Shuai Wu, Yijun Zheng, Shuanghao Zheng, Sen Wang, Chenglin Sun, Khaled Parvez, Taichi Ikeda, Xinhe Bao, Klaus Müllen, Xinliang Feng
Stacked-layer heterostructure films of 2D thiophene nanosheets and electrochemically exfoliated graphene are constructed for ultrahigh rate all-solid-state flexible pseudocapacitors and micro-supercapacitors with superior volumetric capacitance due to the synergetic effect of ultrathin pseudocapacitive thiophene nanosheets and capacitive electrochemically exfoliated graphene.
November 15, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27852233/two-unusual-cases-of-successful-treatment-of-hypermucoviscous-klebsiella-pneumoniae-invasive-syndrome
#6
Hiroki Namikawa, Koichi Yamada, Hiroki Fujimoto, Ken-Ichi Oinuma, Yoshihiro Tochino, Yasuhiko Takemoto, Yukihiro Kaneko, Taichi Shuto, Hiroshi Kakeya
BACKGROUND: A few Japanese cases of hypermucoviscous Klebsiella pneumoniae (K. pneumoniae) invasive syndrome have recently been reported. Although extrahepatic complications from bacteremic dissemination have been observed, infected aneurysms are rare. Furthermore, the primary source of infection is generally a liver abscess, and is rarely the prostate. Therefore, we report two atypical cases of hypermucoviscous K. pneumoniae invasive syndrome. CASE PRESENTATION: The first case was an 81-year-old Japanese man with no significant medical history, who was referred to our hospital for vision loss in his right eye...
November 16, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27849874/232-pulmonary-hypertension-associated-with-acute-respiratory-failure-among-pediatric-patients
#7
Atsushi Numaguchi, Taichi Kato, Naoyuki Matsuda
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847653/nondestructive-microcomputed-tomography-evaluation-of-mineral-density-in-exfoliated-teeth-with-hypophosphatasia
#8
Sachiko Hayashi-Sakai, Takafumi Hayashi, Makoto Sakamoto, Jun Sakai, Junko Shimomura-Kuroki, Hideyoshi Nishiyama, Kouji Katsura, Makiko Ike, Yutaka Nikkuni, Miwa Nakayama, Marie Soga, Taichi Kobayashi
Most cases of hypophosphatasia (HPP) exhibit early loss of primary teeth. Results of microcomputed tomography (micro-CT) analysis of teeth with HPP have rarely been reported. The purpose of the present study was to describe the mineral density distribution and mapping of exfoliated teeth from an HPP patient using micro-CT. Four exfoliated teeth were obtained from a patient with HPP. Enamel and dentin mineral densities of exfoliated teeth were measured on micro-CT. The mean values of enamel and dentin mineral densities in mandibular primary central incisors with HPP were 1...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27843681/successful-surgical-strategy-for-a-cervical-hemangioblastoma-case-report
#9
Hideaki Imai, Kazuhiko Ishii, Hirotaka Chikuda, Junichi Ohya, Daichi Nakagawa, Tomomasa Kondo, Seiji Nomura, Masanori Yoshino, Satoru Miyawaki, Taichi Kin, Hirofumi Nakatomi, Nobuhito Saito
BACKGROUND: Hemangioblastomas are hypervascular lesions and hence their surgical management is challenging. In particular, if complete resection is to be attained, all feeding and draining vessels must be occluded. Although most intramedullary spinal cord tumors are treated utilizing a posterior approach, we describe an anterior surgical strategy for resection of an intramedullary cervical hemangioblastoma. CASE DESCRIPTION: A 36-year-old female with a spinal hemangioblastoma located in the anterior cervical spinal cord presented with a long-standing history of motor weakness of the right upper extremity...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27833427/effects-of-an-increase-in-population-of-sika-deer-on-beetle-communities-in-deciduous-forests
#10
Taichi Iida, Masashi Soga, Shinsuke Koike
The overabundance of large herbivores is now recognized as a serious ecological problem. However, the resulting ecological consequences remain poorly understood. The ecological effects of an increase in sika deer, Cervus nippon Temminck (Cervidae), on three insect groups of beetles was investigated: ground beetles (Carabidae), carrion beetles (Silphidae), and dung beetles (Scarabaeidae and Geotrupidae) on Nakanoshima Island, Hokkaido, northern Japan. We collected beetles on Nakanoshima Island (experimental site) and lakeshore areas (control site) and compared the species richness, abundance, diversity index, and community composition of beetles between the sites...
2016: ZooKeys
https://www.readbyqxmd.com/read/27832387/incidence-of-hypophosphatemia-in-advanced-cancer-patients-a-recent-report-from-a-single-institution
#11
Taichi Yoshida, Daiki Taguchi, Koji Fukuda, Kazuhiro Shimazu, Masahiro Inoue, Katsunori Murata, Hiroyuki Shibata
BACKGROUND: Recent approval of molecular-targeted agents has contributed to improving the therapeutic outcomes of advanced cancer patients. However, they result in unusual adverse events that rarely occur with cytotoxic agents, such as hypertension, hypomagnesemia, and an acne-like rash. Although hypophosphatemia can be induced by various agents, some kinds of molecular-targeted agents are known to induce it. In addition, cancer survivors may be at a risk of hypophosphatemia. METHODS: One hundred and seventy patients, who visited the Department of Clinical Oncology at Akita University from 1 April 2014 to 31 August 2016 were enrolled in this study after providing informed consent...
November 10, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27829954/the-effects-of-ramelteon-on-glucose-metabolism-and-sleep-quality-in-type-2-diabetic-patients-with-insomnia-a-pilot-prospective-randomized-controlled-trial
#12
Tetsuji Tsunoda, Masayo Yamada, Tomoaki Akiyama, Taichi Minami, Taishi Yoshii, Yoshinobu Kondo, Shinobu Satoh, Yasuo Terauchi
BACKGROUND: Insomnia is associated with the onset and development of diabetes. Melatonin affects sleep quality and glucose metabolism in diabetic patients with insomnia. We administered ramelteon, an agonist of melatonin, to type 2 diabetic patients and investigated its effects on glucose metabolism and insomnia. METHODS: This multicenter, prospective, randomized, and observational pilot study was performed between April 2014 and April 2015 at three institutes in Japan...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27827401/alcohol-consumption-genetic-variants-in-the-alcohol-and-folate-metabolic-pathways-and-colorectal-cancer-risk-the-jphc-study
#13
Thomas Svensson, Taiki Yamaji, Sanjeev Budhathoki, Akihisa Hidaka, Motoki Iwasaki, Norie Sawada, Manami Inoue, Shizuka Sasazuki, Taichi Shimazu, Shoichiro Tsugane
The association between alcohol intake and colorectal cancer (CRC) may vary secondary to single nucleotide polymorphisms (SNPs) in two pathways related to alcohol intake. 375 cases of CRC were identified among 38 373 Japan Public Health Center-based prospective Study (JPHC Study) participants who had returned a baseline questionnaire, reported no diagnosis of any cancer and provided blood samples. For each case, two controls were selected on matching variables. Logistic regression models were used to determine matched Odds Ratios (OR) and 95% Confidence Intervals (CI) for the association between alcohol consumption, genetic polymorphisms of enzymes in the alcohol- and folate metabolic pathways (e...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819655/observation-of-the-spin-polarized-surface-state-in-a-noncentrosymmetric-superconductor-bipd
#14
Madhab Neupane, Nasser Alidoust, M Mofazzel Hosen, Jian-Xin Zhu, Klauss Dimitri, Su-Yang Xu, Nagendra Dhakal, Raman Sankar, Ilya Belopolski, Daniel S Sanchez, Tay-Rong Chang, Horng-Tay Jeng, Koji Miyamoto, Taichi Okuda, Hsin Lin, Arun Bansil, Dariusz Kaczorowski, Fangcheng Chou, M Zahid Hasan, Tomasz Durakiewicz
Recently, noncentrosymmetric superconductor BiPd has attracted considerable research interest due to the possibility of hosting topological superconductivity. Here we report a systematic high-resolution angle-resolved photoemission spectroscopy (ARPES) and spin-resolved ARPES study of the normal state electronic and spin properties of BiPd. Our experimental results show the presence of a surface state at higher-binding energy with the location of Dirac point at around 700 meV below the Fermi level. The detailed photon energy, temperature-dependent and spin-resolved ARPES measurements complemented by our first-principles calculations demonstrate the existence of the spin-polarized surface states at high-binding energy...
November 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27815610/matrix-assisted-laser-desorption-ionization-imaging-mass-spectrometry-reveals-changes-of-phospholipid-distribution-in-induced-pluripotent-stem-cell-colony-differentiation
#15
Yasuo Shimizu, Motoyasu Satou, Keitaro Hayashi, Yusuke Nakamura, Mio Fujimaki, Yasuhiro Horibata, Hiromi Ando, Taiji Watanabe, Taichi Shiobara, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Naohiko Anzai, Yoshiki Ishii
Induced pluripotent stem cells (iPSCs) are opening up new possibilities for medicine. Understanding the regulation of iPSC biology is important when attempting to apply these cells to disease models or therapy. Changes of lipid metabolism in iPSCs were investigated by matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry (MALDI-TOF-IMS). Analysis revealed changes of the intensity and distribution of peaks at m/z 782.5 and 798.5 in iPSC colonies during spontaneous differentiation...
November 4, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27814416/painful-purple-toes
#16
Chika Ohata, Taichi Imamura
No abstract text is available yet for this article.
September 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27803415/toxoplasmic-encephalitis-with-untreated-hairy-cell-leukemia-variant
#17
Taichi Ikebe, Hitohiro Sasaki, Hiroyuki Takata, Yasuhiko Miyazaki, Eiichi Ohtsuka, Yoshio Saburi, Masao Ogata, Kuniaki Shirao
Toxoplasmic encephalitis is a rare infectious complication in patients with hematological malignancy except for allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of possible toxoplasmic encephalitis with untreated hairy cell leukemia variant. Magnetic resonance imaging showed multiple nodules with surrounding edema in the entire cerebrum. A polymerase chain reaction analysis for Toxoplasma gondii was negative. Her signs and symptoms fully recovered by empirical therapy with sulfadiazine and pyrimethamine...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27799539/membrane-protein-structure-determination-by-sad-sir-or-siras-phasing-in-serial-femtosecond-crystallography-using-an-iododetergent
#18
Takanori Nakane, Shinya Hanashima, Mamoru Suzuki, Haruka Saiki, Taichi Hayashi, Keisuke Kakinouchi, Shigeru Sugiyama, Satoshi Kawatake, Shigeru Matsuoka, Nobuaki Matsumori, Eriko Nango, Jun Kobayashi, Tatsuro Shimamura, Kanako Kimura, Chihiro Mori, Naoki Kunishima, Michihiro Sugahara, Yoko Takakyu, Shigeyuki Inoue, Tetsuya Masuda, Toshiaki Hosaka, Kensuke Tono, Yasumasa Joti, Takashi Kameshima, Takaki Hatsui, Makina Yabashi, Tsuyoshi Inoue, Osamu Nureki, So Iwata, Michio Murata, Eiichi Mizohata
The 3D structure determination of biological macromolecules by X-ray crystallography suffers from a phase problem: to perform Fourier transformation to calculate real space density maps, both intensities and phases of structure factors are necessary; however, measured diffraction patterns give only intensities. Although serial femtosecond crystallography (SFX) using X-ray free electron lasers (XFELs) has been steadily developed since 2009, experimental phasing still remains challenging. Here, using 7.0-keV (1...
October 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27799315/ep4-receptor-associated-protein-in-macrophages-protects-against-bleomycin-induced-pulmonary-inflammation-in-mice
#19
Sei Higuchi, Risako Fujikawa, Taichi Ikedo, Kosuke Hayashi, Mika Yasui, Manabu Nagata, Masato Nakatsuji, Masayuki Yokode, Manabu Minami
Excessive activation of inflammatory macrophages drives the pathogenesis of many chronic diseases. EP4 receptor-associated protein (EPRAP) has been identified as a novel, anti-inflammatory molecule in macrophages. In this study, we investigated the role of EPRAP using a murine model of bleomycin (BLM)-induced pulmonary inflammation. When compared with wild-type mice, EPRAP-deficient mice exhibited significantly higher mortality, and increased accumulation of macrophages and proinflammatory molecules in the lung 7 d post-BLM administration...
October 31, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27798952/the-relationship-between-vegetable-fruit-consumption-and-gallbladder-bile-duct-cancer-a-population-based-cohort-study-in-japan
#20
Takeshi Makiuchi, Tomotaka Sobue, Tetsuhisa Kitamura, Junko Ishihara, Norie Sawada, Motoki Iwasaki, Shizuka Sasazuki, Taiki Yamaji, Taichi Shimazu, Shoichiro Tsugane
Vegetable and fruit consumption may have a protective effect against several types of cancers. However, the effect on biliary cancers is unclear. We investigated the association of vegetable/fruit consumption with the risks of gallbladder cancer (GBC), intrahepatic bile duct cancer (IHBDC) and extrahepatic bile duct cancer (EHBDC) in a population-based prospective cohort study in Japan. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazard model, and the exposure level was categorized into quartiles, with the lowest group used as the reference...
October 31, 2016: International Journal of Cancer. Journal International du Cancer
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