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https://www.readbyqxmd.com/read/29049803/prognostic-significance-of-immune-nutritional-parameters-for-surgically-resected-elderly-lung-cancer-patients-a-multicentre-retrospective-study
#1
Fumihiro Shoji, Naoko Miura, Taichi Matsubara, Takaki Akamine, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Gouji Toyokawa, Tomoyoshi Takenaka, Koji Yamazaki, Tatsuro Okamoto, Sadanori Takeo, Yoshihiko Maehara
OBJECTIVES: The world's population is rapidly ageing, and the age of patients with lung cancer will increase as well. The prognostic nutritional index, controlling nutritional status and the geriatric nutritional risk index (GNRI) are useful parameters for evaluating immune-nutritional status. We aimed to perform a multicentre retrospective study to investigate the correlations of these immune-nutritional parameters with postoperative comorbidities or surgical outcomes of elderly patients with non-small-cell lung cancer (NSCLC)...
October 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048762/clinical-factors-associated-with-the-symptoms-of-constipation-in-patients-with-diabetes-mellitus-a-multicenter-study
#2
Eiji Yamada, Yulia Namiki, Yuya Takano, Hikaru Takamine, Koji Inazumi, Hiroto Sasaki, Masayo Yamada, Satoshi Ito, Tomoyuki Iwasaki, Naoki Mantani, Taichi Minami, Uru Nezu Osada, Yasuo Terauchi, Atsushi Nakajima
BACKGROUND AND AIM: Changes in treatment protocols for patients with diabetes mellitus (DM) may influence the functions of the digestive tract. This study examined possible clinical factors associated with the symptoms of constipation in patients with DM. METHODS: This was a multicenter study. Participants were consecutive Japanese patients undergoing treatment for type 1 or type 2 DM. Constipation was evaluated using the gastrointestinal symptom rating scale. Diabetic neuropathy was evaluated by the presence or absence of peripheral neuropathy of the lower limbs...
October 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29047743/subpixel-reconstruction-for-single-shot-phase-imaging-with-coded-diffraction
#3
Ryoichi Horisaki, Taichi Kojima, Kyoji Matsushima, Jun Tanida
We present an algorithm for reconstructing an object complex field with resolution below that of an image sensor (subpixel resolution) in single-shot diffractive imaging with coded diffraction. The algorithm employs subpixel phase retrieval and sparse regularization based on compressive sensing. This is useful for high-speed or high-sensitivity imaging using an image sensor with a low pixel count and/or a large pixel size. We experimentally demonstrated the proposed method with two types of moving objects.
September 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047261/deciphering-the-genes-for-taste-receptors-for-fructose-in-drosophila
#4
Shun Uchizono, Taichi Q Itoh, Haein Kim, Naoki Hamada, Jae Young Kwon, Teiichi Tanimura
Taste sensitivity to sugars plays an essential role in the initiation of feeding behavior. In Drosophila melanogaster, recent studies have identified several gustatory receptor (Gr) genes required for sensing sweet compounds. However, it is as yet undetermined how these GRs function as taste receptors tuned to a wide range of sugars. Among sugars, fructose has been suggested to be detected by a distinct receptor from other sugars. While GR43A has been reported to sense fructose in the brain, it is not expressed in labellar gustatory receptor neurons that show taste response to fructose...
October 17, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29044100/experimental-realization-of-two-dimensional-dirac-nodal-line-fermions-in-monolayer-cu2si
#5
Baojie Feng, Botao Fu, Shusuke Kasamatsu, Suguru Ito, Peng Cheng, Cheng-Cheng Liu, Ya Feng, Shilong Wu, Sanjoy K Mahatha, Polina Sheverdyaeva, Paolo Moras, Masashi Arita, Osamu Sugino, Tai-Chang Chiang, Kenya Shimada, Koji Miyamoto, Taichi Okuda, Kehui Wu, Lan Chen, Yugui Yao, Iwao Matsuda
Topological nodal line semimetals, a novel quantum state of materials, possess topologically nontrivial valence and conduction bands that touch at a line near the Fermi level. The exotic band structure can lead to various novel properties, such as long-range Coulomb interaction and flat Landau levels. Recently, topological nodal lines have been observed in several bulk materials, such as PtSn4, ZrSiS, TlTaSe2 and PbTaSe2. However, in two-dimensional materials, experimental research on nodal line fermions is still lacking...
October 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/29034025/replacement-of-the-thoracoabdominal-aorta-after-endovascular-abdominal-aneurysm-repair-for-ruptured-infected-aneurysm-a-case-report
#6
Nobuo Kondo, Kentaro Tamura, Taichi Sakaguchi, Genta Chikazawa, Hidenori Yoshitaka
A 73-year-old man underwent emergency endovascular abdominal aneurysm repair (EVAR) for a ruptured infected abdominal aortic aneurysm. Two years after EVAR, he was admitted with a spiking fever and left lower back pain. Computed tomography scan revealed not only recurrent graft infection with psoas abscess but also infection around the orifice of the superior mesenteric artery. Because conservative medical therapy with antibiotics could not control the infection, we performed complete removal of the infected stent graft, debridement of psoas abscess, and in situ replacement of the thoracoabdominal aorta using rifampicin-soaked prosthetic grafts, followed by the omental flap...
March 24, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032200/sez6l2-regulates-phosphorylation-of-add-and-neuritogenesis
#7
Hiroaki Yaguchi, Ichiro Yabe, Hidehisa Takahashi, Masashi Watanabe, Taichi Nomura, Takahiro Kano, Masaki Matsumoto, Keiichi I Nakayama, Masahiko Watanabe, Shigetsugu Hatakeyama
Increasing evidence shows that immune-mediated mechanisms may contribute to the pathogenesis of central nervous system disorders including cerebella ataxias, as indicated by the aberrant production of neuronal surface antibodies. We previously reported a patient with cerebellar ataxia associated with production of a new anti-neuronal antibody, anti-seizure-related 6 homolog like 2 (Sez6l2). Sez6l2 is a type 1 membrane protein that is highly expressed in the hippocampus and cerebellar cortex and mice lacking Sez6l2 protein family members develop ataxia...
October 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29027045/characteristics-of-patients-with-fragility-hip-fractures-in-the-northern-kyushu-district-in-japan-a-multicenter-prospective-registry-based-on-an-electronic-data-capture-system
#8
Akiko Oyamada, Yoshihiro Matsumoto, Yoshifumi Wakata, Atsushi Kimura, Ko Ikuta, Kuniyoshi Tsuchiya, Naohisa Tayama, Shinji Tomari, Hisaaki Miyahara, Takao Mae, Hirokazu Shiraishi, Taichi Saito, Takeshi Arizono, Kozo Kaji, Taro Mawatari, Masami Fujiwara, Riku Sakimura, Kunichika Shin, Kenichi Ninomiya, Kazutoshi Nakaie, Yasuaki Antoku, Shoji Tokunaga, Naoki Nakashima, Yukihide Iwamoto, Yasuharu Nakashima
Osteoporosis has become a worldwide public health problem, in part due to the fact that it increases the risk of fragility hip fractures (FHFs). The epidemiological assessment of FHFs is critical for their prevention; however, datasets for FHFs in Japan remain scarce. This was a multicenter, prospective, observational study in the northern district of Kyushu Island. Inclusion criteria were age > 60 years with a diagnosis of FHF and acquisition of clinical data by an electronic data capture system. Of 1294 registered patients, 1146 enrolled in the study...
October 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29026270/longitudinal-study-on-the-effectiveness-of-vitamin-d-supplements-in-exclusively-breast-fed-infants
#9
Shintaro Terashita, Taichi Nakamura, Noboru Igarashi
Vitamin D deficiency is a common health problem in infancy. Breast-fed infants are at a higher risk of rickets than formula-fed infants. We observed fluctuations in vitamin D levels in infancy (phase I, 2009-2010) and considered the benefits of vitamin D supplementation specifically in exclusively breast-fed infants in Japan (phase II, 2015). Infants born at our hospital were enrolled in this study. In phase I, we measured 25-hydroxyvitamin D [25(OH)D] levels at 1- to 6-mo intervals from birth. In phase II, we measured 25(OH)D levels before and after supplementation...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29021585/perceived-stress-level-and-risk-of-cancer-incidence-in-a-japanese-population-the-japan-public-health-center-jphc-based-prospective-study
#10
Huan Song, Eiko Saito, Norie Sawada, Sarah K Abe, Akihisa Hidaka, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Motoki Iwasaki, Shizuka Sasazuki, Weimin Ye, Manami Inoue, Shoichiro Tsugane
Evidence regarding stress as a risk factor for cancer onset is inconsistent. In this study, based on the Japan Public Health Center-based Prospective Study, we enrolled 101,708 participants aged 40-69 years from 1990-1994. The self-reported perceived stress level was collected at baseline and updated through 5-year follow-up. The association between perceived stress and cancer risk was measured by Cox proportional hazards regression model, adjusted for all known confounders. During follow-up (mean = 17...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29016859/a-functional-variant-in-mir4300hg-the-host-gene-of-microrna-mir4300-is-associated-with-progression-of-adolescent-idiopathic-scoliosis
#11
Yoji Ogura, Ikuyo Kou, Yohei Takahashi, Kazuki Takeda, Shohei Minami, Noriaki Kawakami, Koki Uno, Manabu Ito, Ikuho Yonezawa, Takashi Kaito, Haruhisa Yanagida, Kei Watanabe, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Toshiaki Kotani, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Nobuyuki Fujita, Mitsuru Yagi, Kazuhiro Chiba, Michiaki Kubo, Yoichiro Kamatani, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting millions of children. Since treatment and prognosis of AIS depend on curve progression, identifying factors related to AIS curve progression is important in its management. Although several genetic loci for AIS occurrence are reported, no locus for curve progression has been identified. To identify genes associated with AIS progression, we conducted a genome-wide association study followed by a replication study using a total of 2,543 AIS subjects who were evaluated for the curve progression...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28993640/reconstruction-of-non-error-magnetic-hologram-data-by-magnetic-assist-recording
#12
Zen Shirakashi, Taichi Goto, Hiroyuki Takagi, Yuichi Nakamura, Pang Boey Lim, Hironaga Uchida, Mitsuteru Inoue
Hologram memory is expected to be the next-generation of optical data storage technology. Bismuth-substituted yttrium iron garnet is typically used for rewritable magnetic hologram media. The diffraction efficiency of magnetic holography depends on the Faraday rotation angle, but the experimental diffraction efficiency is not as high as that expected from calculations. This difference could be caused by incomplete magnetization reversal at the recorded region. In this study, we investigated the effects of magnetic assist (MA) recording through numerical simulation and experiment to improve the diffraction efficiency and the resulting reconstructed images...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992971/diabetes-mellitus-adversely-affects-mortality-and-recurrence-after-valve-surgery-for-infective-endocarditis
#13
Daisuke Yoshioka, Koichi Toda, Jun-Ya Yokoyama, Ryohei Matsuura, Shigeru Miyagawa, Satoshi Kainuma, Taichi Sakaguchi, Masayuki Sakaki, Hiroyuki Nishi, Yukitoshi Shirakawa, Keiji Iwata, Hitoshi Suhara, Ryoto Sakaniwa, Hirotsugu Fukuda, Yoshiki Sawa
BACKGROUND: Although diabetes mellitus (DM) increases the incidence of infective endocarditis (IE), little is known about the outcome of valve surgery for active IE in patients with DM. We evaluated the clinical outcomes of valve surgery for IE in patients with DM. METHODS: Between 2009 and 2016, 470 patients underwent valve surgery for definitive left-sided active IE at 12 affiliated hospitals. We compared the preoperative variables and clinical outcomes between patients without (n = 374) and with DM (n = 96)...
September 15, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28992216/links-between-natural-variation-in-the-microbiome-and-host-fitness-in-wild-mammals
#14
Taichi A Suzuki
Recent studies in model organisms have shown that compositional variation in the microbiome can affect a variety of host phenotypes including those related to digestion, development, immunity, and behavior. Natural variation in the microbiome within and between natural populations and species may also affect host phenotypes and thus fitness in the wild. Here, I review recent evidence that compositional variation in the microbiome may affect host phenotypes and fitness in wild mammals. Studies over the last decade indicate that natural variation in the mammalian microbiome may be important in the assistance of energy uptake from different diet types, detoxification of plant secondary compounds, protection from pathogens, chemical communication, and behavior...
July 25, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28991572/chronologic-and-geographic-trends-of-triangular-fibrocartilage-complex-repair
#15
REVIEW
Taichi Saito, Jennifer M Sterbenz, Kevin C Chung
This article shows trends in triangular fibrocartilage complex (TFCC) repair since 1990 by geographic area and year. The repair methods presented in the literature were inside-out, outside-in, all-inside, and open repair. The outside-in technique was reported most often for ulnar-side tears, whereas the inside-out technique was reported most frequently for radial-side tears. Recently, a foveal reattachment technique for ulnar-side tears has garnered attention and has been reported with increasing frequency, especially in Asia, because the deepest portion of TFCC, attached to fovea, plays a key role in stabilizing the distal radioulnar joint...
November 2017: Hand Clinics
https://www.readbyqxmd.com/read/28984228/substitutions-at-residues-300-and-389-of-the-vp2-capsid-protein-serve-as-the-minimal-determinant-of-attenuation-for-canine-parvovirus-vaccine-strain-9985-46
#16
Go Sehata, Hiroaki Sato, Morimasa Yamanaka, Takuo Takahashi, Risa Kainuma, Tatsuhiko Igarashi, Sho Oshima, Taichi Noro, Eiji Oishi
Identifying molecular determinants of virulence attenuation in live attenuated canine parvovirus (CPV) vaccines is important for assuring their safety. To this end, we identified mutations in the attenuated CPV 9985-46 vaccine strain that arose during serial passage in Crandell-Rees feline kidney cells by comparison with the wild-type counterpart, as well as minimal determinants of the loss of virulence. Four amino acid substitutions (N93K, G300V, T389N and V562L) in VP2 of strain 9985-46 significantly restricted infection in canine A72 cells...
October 6, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28982891/positive-conversion-of-pd-l1-expression-after-treatments-with-chemotherapy-and-nivolumab
#17
Naoki Haratake, Gouji Toyokawa, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Shinkichi Takamori, Takaki Akamine, Yuichi Yamada, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND/AIM: Few studies have so far described the conversion of programmed death-ligand 1 (PD-L1) after treatment. In particular, the effect of nivolumab on the PD-L1 expression has never been reported. We investigated the changes in PD-L1 expression after chemotherapy and nivolumab treatment and herein describe the detailed clinical course. PATIENTS AND METHODS: We retrospectively examined the PD-L1 expression in resected specimens and in the re-biopsy specimens of patients with non-small cell lung cancer by immunohistochemical analysis...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28980429/metabolic-characteristics-of-programmed-cell-death-ligand-1-expressing-lung-cancer-on-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#18
Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Shingo Baba, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Fumihiro Shoji, Hiroshi Honda, Yoshinao Oda, Yoshihiko Maehara
Programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) have been identified as novel targets of immunotherapy of lung cancer. In present study, we evaluated the metabolic characteristics of lung cancer by using (18) F-fluorodeoxyglucose positron emission tomography/computed tomography ((18) F-FDG PET/CT) with regard to PD-L1 protein expression. PD-L1 protein expression was evaluated by immunohistochemistry with the antibody clone SP142 in 579 surgically resected primary lung cancer patients...
October 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28978481/dms-seq-for-in%C3%A2-vivo-genome-wide-mapping-of-protein-dna-interactions-and-nucleosome-centers
#19
Taichi Umeyama, Takashi Ito
Protein-DNA interactions provide the basis for chromatin structure and gene regulation. Comprehensive identification of protein-occupied sites is thus vital to an in-depth understanding of genome function. Dimethyl sulfate (DMS) is a chemical probe that has long been used to detect footprints of DNA-bound proteins in vitro and in vivo. Here, we describe a genomic footprinting method, dimethyl sulfate sequencing (DMS-seq), which exploits the cell-permeable nature of DMS to obviate the need for nuclear isolation...
October 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28977462/the-prognostic-impact-of-distal-anastomotic-new-entry-after-acute-type-i-aortic-dissection-repair
#20
Kentaro Tamura, Genta Chikazawa, Arudo Hiraoka, Toshinori Totsugawa, Taichi Sakaguchi, Hidenori Yoshitaka
OBJECTIVES: Distal anastomotic new entry (DANE) is considered to be one of the causes of patent false lumen (PFL) after acute type I aortic dissection repair. However, there have been few articles with regard to this important issue. We assessed the influence of PFL caused by DANE on long-term outcomes. METHODS: One hundred twenty-two patients underwent emergency surgery for acute type I aortic dissection (2007-12). The in-hospital mortality was 8% (10 patients)...
July 17, 2017: European Journal of Cardio-thoracic Surgery
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