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https://www.readbyqxmd.com/read/29453963/significance-of-spread-through-air-spaces-in-resected-pathological-stage-i-lung-adenocarcinoma
#1
Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: Spread through air spaces (STAS) is a recently described invasive pattern of lung cancer, which spreads within air spaces beyond the edge of the main tumor. In the current study, we investigated the significance of STAS in patients with pathological stage I adenocarcinoma. METHODS: STAS was assessed in a total of 276 patients with resected pathological stage I adenocarcinoma. STAS was classified as either no STAS, low STAS (1-4 single cells or clusters of STAS), or high STAS (≥5 single cells or clusters of STAS) using a 20x objective and a 10x ocular lens...
February 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29448349/transmission-coefficient-from-generalized-cantor-like-potentials-and-its-multifractality
#2
Taichi Ogawana, Hidetsugu Sakaguchi
We study the scattering problem at generalized Cantor-like potentials characterized by the expansion rate a and duplication number N, and derive an exact formula of transmittance. It was found that the transmittance is expressed with Chebyshev polynomials of the second kind, and the multifractality of the reflectance varies depending on a and N.
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447580/hplc-pda-determination-of-carminic-acid-and-4-aminocarminic-acid-using-relative-molar-sensitivities-with-respect-to-caffeine
#3
Yuzo Nishizaki, Naoko Sato-Masumoto, Aki Yokota, Tsuyoshi Mikawa, Koichi Nakashima, Taichi Yamazaki, Miho Kuroe, Masahiko Numata, Toshihide Ihara, Yusai Ito, Naoki Sugimoto, Kyoko Sato
To accurately determine carminic acid (CA) and its derivative 4-aminocarminic acid (4-ACA), a novel, high-performance liquid chromatography with photodiode array detector (HPLC/PDA) method using relative molar sensitivity (RMS) was developed. The method requires no analytical standards of CA and 4-ACA; instead it uses the RMS values with respect to caffeine (CAF), which is used as an internal standard. An off-line combination of 1 H-quantitative nuclear magnetic resonance spectroscopy ( 1 H-qNMR) and HPLC/PDA was able to precisely determine the RMSs of CA 274nm /CAF 274nm and 4-ACA 274nm /CAF 274nm ...
February 15, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29446077/coffee-drinking-and-colorectal-cancer-and-its-subsites-a-pooled-analysis-of-8-cohort-studies-in-japan
#4
Ikuko Kashino, Shamima Akter, Tetsuya Mizoue, Norie Sawada, Ayaka Kotemori, Keitaro Matsuo, Isao Oze, Hidemi Ito, Mariko Naito, Tomio Nakayama, Yuri Kitamura, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Manami Inoue, Chisato Nagata, Atsuko Sadakane, Keitaro Tanaka, Shoichiro Tsugane, Taichi Shimazu
Coffee is a rich source of bioactive compounds that have potential anti-carcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,276 person-years, 6,711 incident colorectal cancer cases were identified...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29444544/uridine-5-diphospho-glucuronosyltransferase-1a-expression-as-an-independent-prognosticator-in-urothelial-carcinoma-of-the-upper-urinary-tract
#5
Koji Izumi, Satoshi Inoue, Hiroki Ide, Kazutoshi Fujita, Taichi Mizushima, Guiyang Jiang, Seiji Yamaguchi, Hiroaki Fushimi, Norio Nonomura, Hiroshi Miyamoto
OBJECTIVE: To determine the expression status of uridine 5'diphospho-glucuronosyltransferase 1A, a major phase II drug metabolism enzyme, in upper urinary tract urothelial carcinoma, as well as to assess its prognostic significance. METHODS: We immunohistochemically stained for uridine 5'diphospho-glucuronosyltransferase 1A in tissue microarray consisting of 99 upper urinary tract urothelial carcinoma samples and paired non-neoplastic urothelial tissues. We also assessed the effect of uridine 5'diphospho-glucuronosyltransferase 1A knockdown on urothelial cancer cell growth...
February 14, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29434114/droplet-counting-microtitration-system-for-precise-on-site-analysis
#6
Susumu Kawakubo, Taichi Omori, Yasutada Suzuki, Ikuo Ueta
A new microtitration system based on the counting of titrant droplets has been developed for precise on-site analysis. The dropping rate was controlled by inserting a capillary tube as a flow resistance in a laboratory-made micropipette. The error of titration was 3% in a simulated titration with 20 droplets. The pre-addition of a titrant was proposed for precise titration within an error of 0.5%. The analytical performances were evaluated for chelate titration, redox titration and acid-base titration.
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29434110/detection-and-quantification-of-4-methylimidazole-in-cola-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry-with-fe2o3-nanoparticles-on-zeolite
#7
Yosuke Fujii, Yuqi Ding, Taichi Umezawa, Takafumi Akimoto, Jiawei Xu, Takashi Uchida, Tatsuya Fujino
Food additives generally used in carbonated drinks, such as 4-methylimidazole (4MI), caffeine (Caf?), citric acid (CA), and aspartame (Apm), were measured by matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) using nanometer-sized particles of iron oxide (Fe2O3 NPs). The quantification of 4MI in Coca Cola (C-cola) was carried out. In order to improve the reproducibility of the peak intensities, Fe2O3 NPs loaded on ZSM5 zeolite were used as the matrix for quantification. By using 2-ethylimidazole (2EI) as the internal standard, the amount of 4MI in C-cola was determined to range from 88 to 65 μg/355 mL...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29427040/novel-epigenetic-markers-for-gastric-cancer-risk-stratification-in-individuals-after-helicobacter-pylori-eradication
#8
Masahiro Maeda, Satoshi Yamashita, Taichi Shimazu, Naoko Iida, Hideyuki Takeshima, Takeshi Nakajima, Ichiro Oda, Sohachi Nanjo, Chika Kusano, Akiko Mori, Hiroshi Moro, Harumi Yamada, Shoichiro Tsugane, Toshiro Sugiyama, Yoshiharu Sakai, Toshikazu Ushijima
BACKGROUND: The risk stratification of healthy individuals after Helicobacter pylori eradication is an urgent issue. The assessment of aberrant DNA methylation accumulated in gastric tissues with normal appearance, which can reflect overall epigenomic damage, is a promising strategy. We aimed to establish novel epigenetic cancer risk markers for H. pylori-eradicated individuals. METHODS: Gastric mucosa was collected from eight healthy volunteers without H. pylori infection (G1), 75 healthy individuals with gastric atrophy (G2), and 94 gastric cancer patients (G3) after H...
February 9, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29421215/sweeping-of-adsorbed-therapeutic-protein-on-prefillable-syringes-promotes-micron-aggregate-generation
#9
Takahiro Maruno, Hiroki Watanabe, Saki Yoneda, Takayuki Uchihashi, Satoru Adachi, Kunihito Arai, Taichi Sawaguchi, Susumu Uchiyama
This study evaluated how differences in the surface properties of prefillable syringe (PFS) barrels and in-solution sampling methods affect micron aggregates and protein adsorption levels. Three syringe types [glass barrel with silicone oil coating (GLS/so+), glass barrel without silicone oil coating (GLS/so-) and cyclo-olefin polymer (COP) barrel syringes] were tested with three therapeutic proteins (adalimumab, etanercept, and infliximab) using two sampling methods (aspiration or ejection). After quiescent incubation, solutions sampled by aspiration exhibited no significant change in micron aggregate concentration in any syringes, whereas those sample by ejection exhibited increased micron aggregates in both GLS syringe types...
February 5, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29420835/validity-of-self-reported-tooth-counts-and-masticatory-status-study-of-a-japanese-adult-population
#10
Masayuki Ueno, Taichi Shimazu, Norie Sawada, Shoichiro Tsugane, Yoko Kawaguchi
Self-reported measures of oral health are often used to assess oral health in populations or groups, but their validity or reliability needs repeated confirmation. The objective of this cross-sectional study was to evaluate the validity of self-reported tooth counts and masticatory status, using data obtained from a sample of Japanese adults. A total of 2,356 adults aged 40 to 75 years participated in a questionnaire survey and a clinical oral examination from 2013 through 2016. Self-reported measures were compared with clinically measured values...
February 8, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29419469/risk-factors-for-relapse-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-in-japan-a-nationwide-prospective-cohort-study
#11
Akinori Hara, Takashi Wada, Ken-Ei Sada, Koichi Amano, Hiroaki Dobashi, Masayoshi Harigai, Yoshinari Takasaki, Hidehiro Yamada, Hitoshi Hasegawa, Taichi Hayashi, Shouichi Fujimoto, Eri Muso, Tamihiro Kawakami, Sakae Homma, Masaharu Yoshida, Junichi Hirahashi, Noriyoshi Ogawa, Satoshi Ito, Hirofumi Makino, Yoshihiro Arimura
OBJECTIVE: The aim was to elucidate the prognosis and risk factors associated with relapse during longterm remission maintenance therapy for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: Patients with newly diagnosed AAV (n = 156) were registered in the Remission Induction Therapy in Japanese patients with ANCA-associated Vasculitides (RemIT-JAV) study, and among them, 83 patients who achieved remission were enrolled and followed up for 24 additional months in our nationwide, prospective cohort study (Co-RemIT-JAV; registration number UMIN 000006373)...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29415266/combined-minimally-invasive-repair-of-the-adult-form-of-the-scimitar-syndrome-and-organic-mitral-regurgitation
#12
Koichi Inoue, Takayoshi Ueno, Arudo Hiraoka, Taichi Sakaguchi
Scimitar syndrome is a rare congenital cardiac malformation defined as an anomalous pulmonary venous return from the right lung to the inferior vena cava. In adult patients, the surgical strategy chosen is very important because of concomitant diseases and conditions. Herein, we present a case in which a minimally invasive approach was successful for treating a combination of the adult form of the scimitar syndrome and severe degenerative mitral regurgitation.
February 5, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29409882/the-efficacy-and-long-term-outcomes-of-autologous-stem-cell-transplantation-in-poems-syndrome-a-nation-wide-survey-in-japan
#13
Chika Kawajiri-Manako, Emiko Sakaida, Chikako Ohwada, Toshihiro Miyamoto, Taichi Azuma, Jun Taguchi, Takehiko Mori, Yuichi Hasegawa, Tadakazu Kondo, Toshiaki Yujiri, Makoto Yoshimitsu, Kazunori Imada, Shingo Kurahashi, Kaoru Kahata, Tatsuo Ichinohe, Makoto Hirokawa, Yoshiko Atsuta, Chiaki Nakaseko
POEMS syndrome is a rare plasma cell dyscrasia presenting with polyneuropathy, λ-type M protein, VEGF elevation, and systemic manifestations. The standard treatment has not been established, but autologous stem cell transplantation (ASCT) has exhibited effectiveness in this syndrome. However, the efficacy and long-term outcomes of ASCT have not been systematically studied. To clarify the efficacy and long-term outcomes of ASCT-treated patients in Japan, we performed a multicenter retrospective study assessing the clinical course of patients registered to the Japan Society for Hematopoietic Cell Transplantation TRUMP database...
January 31, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29408989/modified-predictive-score-based-on-frailty-for-mid-term-outcomes-in-open-total-aortic-arch-surgery
#14
Arudo Hiraoka, Kazuya Saito, Genta Chikazawa, Toshinori Totsugawa, Kentaro Tamura, Atsuhisa Ishida, Taichi Sakaguchi, Hidenori Yoshitaka
OBJECTIVES: The aim of this study was to seek a new predictor of mid-term survival of surgical total aortic arch replacement (SAR) by evaluating indices relevant to frailty. METHODS: Between October 2012 and March 2017, 113 consecutive patients underwent elective surgical total aortic arch replacement with antegrade cerebral perfusion under circulatory arrest at a single cardiovascular institute. In addition to common parameters, Katz index of activities of daily living, nutritional status, skeletal muscle mass volume, swallowing and motor functions were used to evaluate patients' frailty...
February 2, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29401405/molecular-analyses-of-the-agouti-allele-in-the-japanese-house-mice-identify-a-novel-variant-of-the-agouti-gene
#15
Masahiro A Iwasa, Sayaka Kawamura, Hikari Myoshu, Taichi A Suzuki
It has been thought that Japanese house mice carry the Aw allele at the agouti locus causing light-colored bellies, but they do not always show this coloration. Thus, the presence of the Aw allele seems to be doubtful in them. To ascertain whether the Aw allele is present, a two-pronged approach was used. First, we compared lengths of DNA fragments obtained from three PCRs conducted on them to the known fragment sizes generated from mouse strains exhibiting homozygosities of either a/a, A/A, or Aw/Aw. PCRs I, II, and III can amplify only in the A and Aw alleles, the a and Aw alleles, and the a allele, respectively, and we detected amplifications in strains with A/A and Aw/Aw by PCR I, in those with a/a and Japanese house mice by PCR II, and in those with a/a by PCR III...
February 5, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29394859/-applicability-of-pedicled-coronoid-process-and-temporal-muscle-fascial-combined-pcptm-flap-for-reconstruction-of-orbital-floor-defect-following-hemi-maxillectomy-for-advanced-maxillary-cancer-a-report-of-two-cases
#16
Masaaki Karino, Takahiro Kanno, Ichiro Kaneko, Taichi Ide, Aya Yoshino, Joji Sekine
We usually perform surgery for resectable oral and maxillofacial carcinomas. Following complete cancer resection, reconstruction of soft and hard tissues using various types of local flaps and/or vascularized free flaps is usually performed. The maxilla is composed of various anatomical structures. In particular, reconstruction of the orbit is one of the most important and challenging procedures for prevention of functional and esthetic complications. Here we report 2 cases of orbital floor defect reconstruction following advanced maxillary cancer resection using a pedicled coronoid process and temporal muscle (fascial)combined(PCPTM)flap...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394643/-a-case-with-solitary-brain-metastatic-tumor-from-colon-cancer
#17
Masamichi Kimura, Hiroyuki Tanishima, Taichi Tatsubayashi, Shinji Iwakura, Toshiji Tominaga, Tetsuya Horiuchi
We report a rare long-surviving case of solitary brain metastasis from colon cancer. The patient was a 64-year-old female. She had undergone laparoscopic right hemicolectomy for ascending colon cancer in October 2012(pStage III b). She was discharged from the hospitalin a satisfactory state, but 26 days after the operation, she was transported to the emergency department for systemic tonic-clonic convulsions. Magnetic resonance imaging revealed solitary metastatic tumor in the brain, but there were no metastatic lesions in other organs...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394546/-cystic-duct-cancer-with-postoperative-liver-metastasis-that-achieved-complete-response-after-gemcitabine-treatment-a-case-report
#18
Yuto Mitsuhashi, Norihisa Kimura, Keinosuke Ishido, Daisuke Kudo, Taichi Wakiya, Yuta Yakoshi, Yoshikazu Toyoki, Kenichi Hakamada
A 72-year-old woman was diagnosed with gallbladder cancer and underwent extended cholecystectomy and extrahepatic bile duct resection. The pathological findings were CGnBdGb, circ, nodular infiltrating type, 20×10 mm, tub2, pT3b, int, INF c, ly1, v1, ne3, pN0, pDM0, pHM0, pEM0, pPV0, pA0, R0, Stage III A. Because the main localization was in the cystic duct, we diagnosed this as cystic duct cancer. Seven months after surgery, follow-up computed tomography scan revealed a metastatic region in segment 7 of the liver...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29386515/infliximab-versus-intravenous-immunoglobulin-for-refractory-kawasaki-disease-a-phase-3-randomized-open-label-active-controlled-parallel-group-multicenter-trial
#19
Masaaki Mori, Takuma Hara, Masako Kikuchi, Hiroyuki Shimizu, Tomoyuki Miyamoto, Satoru Iwashima, Tatsuya Oonishi, Kunio Hashimoto, Norimoto Kobayashi, Kenji Waki, Yasuo Suzuki, Yoshikazu Otsubo, Hiroshi Yamada, Chikao Ishikawa, Taichi Kato, Shigeto Fuse
We compared the efficacy and safety of infliximab with intravenous immunoglobulin (IVIG), a standard therapy, in a phase 3 trial (NCT01596335) for Japanese patients with Kawasaki disease (KD) showing persistent fever after initial IVIG. Patients with initial IVIG-refractory KD, aged 1-10 years, received a single dose of IV infliximab 5 mg/kg or IV polyethylene glycol-treated human immunoglobulin (VGIH) 2 g/kg on day 0. Primary outcome was defervescence rate within 48 h after the start of treatment. Safety was evaluated through day 56...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29384263/possible-involvement-of-il-6-producing-tissue-resident-macrophages-in-early-onset-pericardial-effusion-pathogenesis-after-hematopoietic-stem-cell-transplantation
#20
Satoru Hamada, Jiro Miyamoto, Tokiko Oshiro, Takeshi Yagi, Shinobu Kiyuna, Taichi Uehara, Takehiro Matsuda, Takeshi Higa, Nobuyuki Hyakuna, Koichi Nakanishi
PURPOSE: Pericardial effusion (PE) is a potentially life-threatening complication following hematopoietic stem cell transplantation (HCT). A higher incidence of early-onset PE, unrelated to graft-versus-host disease, before day 100 after HCT has been reported in pediatric patients, but the pathogenic mechanism is poorly understood. Aiming to determine the pathogenesis of early-onset PE in pediatric patients, we analyzed the cytokine concentration and cell population in the pericardial fluid of four pediatric patients with PE...
January 31, 2018: Pediatric Blood & Cancer
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