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Naoki Konno, Mitsuru Sugimoto, Tadayuki Takagi, Makiko Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Yoshiaki Miura, Taichi Aihara, Atsushi Komatsuda, Hiromasa Ohira, Hiroshi Watanabe
BACKGROUND: Although increased serum IgG4 level and tissue infiltration of IgG4-positive cells are key events in IgG4-related disease (IgG4RD), and nearly half of IgG4RD patients show hypocomplementemia, the role of IgG4 in the pathogenesis of IgG4RD remains unclear. Many reports show that altered IgG glycosylation, especially IgG with agalactosylated N-linked glycan (G0 N-glycan), have proinflammatory roles including complement activation, implicated in the pathogenesis of various inflammatory diseases...
2018: PloS One
Asuka Kawachi, Taichi Shimazu, Sanjeev Budhathoki, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Evidence on the association between BMI, height, and endometrial cancer risk, including by subtypes, among Asian populations remains limited. We evaluated the impact of BMI and height on the risk of endometrial cancer, overall and by histological subtype. We prospectively investigated 53 651 Japanese women aged 40-69 years. With an average follow-up duration of 18.6 years, 180 newly diagnosed endometrial cancers were reported, including 119 type 1 and 21 type 2. The association between BMI, height, and endometrial cancer risk was assessed using a Cox proportional hazards regression model with adjustment for potential confounders...
April 18, 2018: European Journal of Cancer Prevention
Sangah Shin, Eiko Saito, Norie Sawada, Junko Ishihara, Ribeka Takachi, Akiko Nanri, Taichi Shimazu, Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane
PURPOSE: The development of prostate cancer may be impacted by environmental factors, including diet. The aim of this study was to evaluate the association between dietary patterns and risk of prostate cancer in a large prospective cohort study among Japanese men. METHODS: A total of 43,469 men who participated in the Japan Public Health Center-based Prospective Study were followed from 1995 to 1998 to the end of 2012, during which 1,156 cases of prostate cancer were newly identified...
April 18, 2018: Cancer Causes & Control: CCC
Minoru Sasaki, Yoshitoyo Kodama, Yu Shimoyama, Taichi Ishikawa, Shigenobu Kimura
Although Streptococcus anginosus constitutes a proportion of the normal flora of the gastrointestinal and genital tracts, and the oral cavity, it has been reported that S. anginosus infection could be closely associated with abscesses at various body sites, infective endocarditis, and upper gastrointestinal cancers. The colonization in an acidic environment due to the aciduricity of S. anginosus could be the etiology of the systemic infection of the bacteria. To elucidate the aciduricity and acid tolerance mechanisms of the microbe, we examined the viability and growth of S...
April 17, 2018: Journal of General and Applied Microbiology
Takayuki Isono, Shiori Sugiura, Taichi Terashima, Kazuya Miyagawa, Kazushi Kanoda, Shinya Uji
A quantum spin liquid (QSL) is an exotic state of matter in condensed-matter systems, where the electron spins are strongly correlated, but conventional magnetic orders are suppressed down to zero temperature because of strong quantum fluctuations. One of the most prominent features of a QSL is the presence of fractionalized spin excitations, called spinons. Despite extensive studies, the nature of the spinons is still highly controversial. Here we report magnetocaloric-effect measurements on an organic spin-1/2 triangular-lattice antiferromagnet, showing that electron spins are decoupled from a lattice in a QSL state...
April 17, 2018: Nature Communications
Taichi Sakaguchi, Toshinori Totsugawa, Masahiko Kuinose, Kentaro Tamura, Arudo Hiraoka, Genta Chikazawa, Hidenori Yoshitaka
BACKGROUND: Although minimally invasive mitral valve repair (MIMVR) is increasingly being performed, only a few clinical studies from Japanese institutions have been reported.Methods and Results:From 2006 to 2017, 387 consecutive patients (135 females, mean age 56±13 years) underwent an initial isolated MIMVR through a right minithoracotomy. The mitral etiology was degenerative in 348, functional in 22, and endocarditis in 13 cases. Repair techniques included leaflet resection/plication in 280, chordal reconstruction in 109, and annuloplasty alone in 24 patients, and concomitant procedures included tricuspid valve repair and atrial fibrillation ablation in 70 (18...
April 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Toshiyuki Ishiba, Goshi Oda, Tsuyoshi Nakagawa, Takumi Akashi, Yamato Yamashita, Tomoki Aburatani, Taichi Ogo, Yutaka Nakashima, Hironobu Baba, Naoaki Hoshino, Yoshinobu Nishioka, Tatsuyuki Kawano
Occult breast cancer, which develops as a metastatic lesion with no primary tumor detected in the breast, is a rare breast cancer. A 68-year-old female patient particularly complained of the presence of a right axillary mass. The mass in the right axilla was palpable, but no tumor was found in both the breasts on palpation, ultrasound examination, or MRI. Partial breast resection and axillary lymph node dissection were performed following a diagnosis of invasive ductal carcinoma by core needle biopsy. There was no mammary gland tissue present around the tumor due to the pathology of the disease, and the tumor was diagnosed as occult breast cancer...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Taichi Tatsubayashi, Hiroyuki Tanishima, Shinji Iwakura, Toshiji Tominaga, Masamichi Kimura, Tetsuya Horiuchi, Yoshihiko Hoshida
A 49-year-old man was diagnosed with advanced gastric cancer, with a chief complaint of epigastric discomfort. Computed tomography revealed multiple liver metastases. S-1 plus cisplatin therapy was administered as first-line chemotherapy, and after 4courses, the liver metastases markedly reduced. Total gastrectomy with D2 lymphadenectomy and a needle biopsy of segment 2 of the liver were performed. Histopathological examination revealed no viable cancer cells in the resected stomach, lymph nodes, or liver tissue...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Keiko Saegusa, Miyuki Sato, Nobukatsu Morooka, Taichi Hara, Ken Sato
Lipoproteins regulate the overall lipid homeostasis in animals. However, the molecular mechanisms underlying lipoprotein trafficking remain poorly understood. Here, we show that SFT-4, a Caenorhabditis elegans homologue of the yeast Erv29p, is essential for the endoplasmic reticulum (ER) export of the yolk protein VIT-2, which is synthesized as a lipoprotein complex. SFT-4 loss strongly inhibits the ER exit of yolk proteins and certain soluble cargo proteins in intestinal cells. SFT-4 predominantly localizes at ER exit sites (ERES) and physically interacts with VIT-2 in vivo, which suggests that SFT-4 promotes the ER export of soluble proteins as a cargo receptor...
April 11, 2018: Journal of Cell Biology
Taichi Nakamura, Katsunori Suzuki, Makoto Yamashita
An aluminabenzene-alkylzirconium complex having a half-zirconocene structure was synthesized. X-ray crystallographic analysis of this complex revealed a zwitterionic structure consisting of cationic alkylzirconium chloride and four-coordinated aluminate. In the presence of a catalytic amount of this complex, ethylene polymerization could proceed without any additives to form ultra-high molecular weight polyethylene.
April 9, 2018: Chemical Communications: Chem Comm
Toshinori Totsugawa, Masatoshi Tsunoda, Nobuyuki Kagiyama, Yuki Otsuki, Hidenori Yoshitaka, Taichi Sakaguchi
Transaortic septal myectomy is a procedure that involves a learning curve for surgeons because the bulging interventricular septum usually interferes with the visualization of the deep parts of the left ventricular chamber. In this case report, we demonstrate computed tomography virtual endoscopy for preoperative simulation, which enabled us to clearly image the relationship among the bulging septum, the expected myectomy area, and the structures deep in the left ventricle, such as the papillary muscle and abnormal muscular bundles, which are hidden by the hypertrophic septum, thus preventing visualization...
April 6, 2018: International Heart Journal
Fumi Kishi, Kojiro Nagai, Norimichi Takamatsu, Tatsuya Tominaga, Masanori Tamaki, Eriko Shibata, Taichi Murakami, Seiji Kishi, Hideharu Abe, Yasuhiko Koezuka, Naoto Minagawa, Go Ichien, Toshio Doi
Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted...
2018: PloS One
Arudo Hiraoka, Suguru Shiraya, Genta Chikazawa, Atsuhisa Ishida, Koichi Miyake, Taichi Sakaguchi, Hidenori Yoshitaka
OBJECTIVE: Endovascular procedures for aortic aneurysm repair have become widely accepted as safe and effective surgical options. We investigated the efficacy of the multimodality roadmap (MMR) system with biplane fluoroscopy to attempt to reduce the use of contrast medium and exposure to radiation during surgery. METHODS: We retrospectively reviewed 263 consecutive cases with elective endovascular aneurysm repair (EVAR) and thoracic endovascular aortic repair (TEVAR)...
March 31, 2018: Journal of Vascular Surgery
Yosuke Hari, Arudo Hiraoka, Hidenori Yositaka, Taichi Sakaguchi
Caseous calcification of the mitral annulus (CCMA) is a rare variant of mitral annulus calcification. Herein, we present computed tomographic images of formation of CCMA over time.
March 31, 2018: International Journal of Cardiovascular Imaging
Yuki Fujihara, Taichi Saito, Helen E Huetteman, Jennifer M Sterbenz, Kevin C Chung
A well-organized, thoughtful study design is essential for creating an impactful study. However, pressures promoting high output from researchers can lead to rushed study proposals that overlook critical weaknesses in the study design that can affect the validity of the conclusions. Researchers can benefit from thorough review of past failed proposals when crafting new research ideas. Conceptual frameworks and root cause analysis are two innovative techniques that can be used during study development to identify flaws and prevent study failures...
April 2018: Plastic and Reconstructive Surgery
Taichi Miura, Mayumi Fujita, Mitsuko Kawano, Kaori Imadome, Takeshi Yasuda, Shoko Nishihara, Toru Imamura, Mikio Masuzawa, Takashi Imai, Fumiaki Nakayama
Background and purpose: Angiosarcoma is associated with a poor prognosis and is treated with radiotherapy. Although FGF1 is a potential radioprotector, the influence of FGF1 on the malignancy of angiosarcoma remains unknown. Materials and methods: Highly stable FGF1 mutants, which exhibit stronger mitogenic activity than wild-type FGF1, were examined as strong radioprotectors and signaling agonists to clarify the effects of FGF1 on the murine angiosarcoma cell line ISOS-1...
December 2017: Clinical and Translational Radiation Oncology
Satoshi Inoue, Hiroki Ide, Taichi Mizushima, Guiyang Jiang, George J Netto, Momokazu Gotoh, Hiroshi Miyamoto
We investigated the role of NF-κB in the development and progression of urothelial cancer as well as cross-talk between NF-κB and androgen receptor (AR) signals in urothelial cells. Immunohistochemistry in surgical specimens showed that the expression levels of NF-κB/p65 (P=0.015)/phospho-NF-κB/p65 (P<0.001) were significantly elevated in bladder tumors, compared with those in non-neoplastic urothelial tissues. The rates of phospho-NF-κB/p65 positivity were also significantly higher in high-grade (P=0...
March 28, 2018: Molecular Cancer Therapeutics
Pan Qi, Shinsuke Ohba, Yuichi Hara, Masaya Fuke, Takayuki Ogawa, Seiichi Ohta, Taichi Ito
Calcium phosphate-loaded carboxymethyl cellulose non-woven sheets (CMC/CaP sheet) were fabricated and their potential to induce in vitro osteoblast differentiation and in vivo bone regeneration were investigated. The CMC/CaP sheets were prepared by alternately soaking protonated-CMC non-woven sheets in CaCl2 and Na2 HPO4 aqueous solutions. Because of its slow water uptake rate, the protonated-CMC was successfully loaded with a mixed phase of brushite and hydroxyapatite. In vitro, the CMC/CaP sheet induced osteoblast differentiation of human mesenchymal stromal cells (hMSCs), as shown by calcification and the upregulation of osteoblast marker genes...
June 1, 2018: Carbohydrate Polymers
Junya Sado, Tetsuhisa Kitamura, Tomotaka Sobue, Norie Sawada, Motoki Iwasaki, Shizuka Sasazuki, Taiki Yamaji, Taichi Shimazu, Shoichiro Tsugane
Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer incidence in Western countries. However, few epidemiological studies have assessed the association between anthropometric factors, such as BMI, height, or weight, and thyroid cancer incidence in Asian populations. Using the population-based Japan Public Health Center-based prospective study database, we investigated the relationship between anthropometric factors and thyroid cancer incidence. Data on anthropometric factors were collected through a self-administered questionnaire at baseline...
March 25, 2018: Cancer Medicine
Takashi Nakagawa, Takashi Kobayashi, Shin Nishiumi, Akihisa Hidaka, Taiki Yamaji, Norie Sawada, Yuichi Hirata, Kodai Yamanaka, Takeshi Azuma, Atsushi Goto, Taichi Shimazu, Manami Inoue, Motoki Iwasaki, Masaru Yoshida, Shoichiro Tsugane
Discovery of the high risk group of pancreatic cancer is important for prevention of pancreatic cancer. This study was conducted in a nested case-control study including 170 pancreatic cancer cases and 340 matched controls of our population-based cohort study involving 30,239 subjects who answered a baseline questionnaire and supplied blood samples. The 12 targeted metabolites were quantitatively analyzed by gas chromatography/tandem mass spectrometry. The odds ratios and their corresponding 95% confidence intervals were calculated using conditional logistic regression models...
March 25, 2018: Cancer Science
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