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https://www.readbyqxmd.com/read/28821872/microbiota-in-the-coelomic-fluid-of-two-common-coastal-starfish-species-and-characterization-of-an-abundant-helicobacter-related-taxon
#1
Satoshi Nakagawa, Hikari Saito, Akihiro Tame, Miho Hirai, Hideyuki Yamaguchi, Takashi Sunata, Masanori Aida, Hisashi Muto, Shigeki Sawayama, Yoshihiro Takaki
Marine invertebrates associate with diverse microorganisms. Microorganisms even inhabit coelomic fluid (CF), namely, the fluid filling the main body cavity of echinoderms. The CF microbiota potentially impacts host health and disease. Here, we analysed the CF microbiota in two common coastal starfish species, Patiria pectinifera and Asterias amurensis. Although microbial community structures were highly variable among individual starfish, those of P. pectinifera were compositionally similar to those in the surrounding seawater...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813872/mit-skywalker-evaluating-comfort-of-bicycle-saddle-seat
#2
Rogerio S Goncalves, Taya Hamilton, Ali R Daher, Hiroaki Hirai, Hermano I Krebs
The MIT-Skywalker is a robotic device developed for the rehabilitation of gait and balance after a neurological injury. This device has been designed based on the concept of a passive walker and provides three distinct training modes: discrete movement, rhythmic movement, and balance training. In this paper, we present our efforts to evaluate the comfort of a bicycle/saddle seat design for the system's novel actuated body weight support device. We employed different bicycle and saddle seats and evaluated comfort using objective and subjective measures...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813849/effects-of-partial-body-weight-support-and-functional-electrical-stimulation-on-gait-characteristics-during-treadmill-locomotion-pros-and-cons-of-saddle-seat-type-body-weight-support
#3
Natsumi Kataoka, Hiroaki Hirai, Taya Hamilton, Fumiaki Yoshikawa, Akira Kuroiwa, Yuma Nagakawa, Eichi Watanabe, Yudai Ninomaru, Yuri Saeki, Mitsunori Uemura, Fumio Miyazaki, Hiroshi Nakata, Tomoki Nishi, Hiroaki Naritomi, Hermano Igo Krebs
Robotic therapy for rehabilitation of the lower extremity is currently in its early stage of development. Aiming at exploring an efficacious intervention for gait rehabilitation, we investigate the characteristics of an end-effector gait-training device that combines saddle-seat-type body-weight-supported treadmill training with functional electrical stimulation (FES). This is a task-oriented approach to restoring voluntary control of locomotion in patients with neuromuscular diseases. We evaluate the differences between walking with saddle-seat-type support and with harness-type support, in terms of personal preference, the preferred walking speed, profiles of kinematics and ground reaction force, and the effectiveness of FES...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28810713/co-opted-megasatellite-dna-drives-evolution-of-secondary-night-vision-in-azara-s-owl-monkey
#4
Akihiko Koga, Hideyuki Tanabe, Yuriko Hirai, Hiroo Imai, Masanori Imamura, Takao Oishi, Roscoe Stanyon, Hirohisa Hirai
Owl monkeys (genus Aotus) are the only taxon in simian primates that consists of nocturnal or otherwise cathemeral species. Their night vision is superior to that of other monkeys, apes, and humans but not as good as that of typical nocturnal mammals. This incomplete night vision has been used to conclude that these monkeys only secondarily adapted to a nocturnal lifestyle, or to their cathemeral lifestyle that involves high night-time activity. It is known that the rod cells of many nocturnal mammals possess a unique nuclear architecture in which heterochromatin is centrally located...
July 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28810583/kidney-dysfunction-following-adrenalectomy-in-autosomal-dominant-polycystic-kidney-disease-complicated-with-primary-aldosteronism-a-case-report
#5
Hiroyuki Hirai, Makoto Kanno, Tsuyoshi Watanabe, Hiroaki Satoh
The present study reported a case of autosomal dominant polycystic kidney disease complicated with primary aldosteronism in a 49-year-old woman. The patient was referred for refractory hypertension. Laboratory examinations revealed low potassium and renin levels. Computed tomography indicated a right adrenal tumor and multiple renal cysts. Adrenal vein sampling revealed a high aldosterone level on the side of the tumor. The patient was diagnosed with autosomal dominant polycystic kidney disease complicated by primary aldosteronism and adrenalectomy was performed...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807982/c-ebp%C3%AE-is-required-for-survival-of-ly6c-monocytes
#6
Akihiro Tamura, Hideyo Hirai, Asumi Yokota, Naoka Kamio, Atsushi Sato, Tsukimi Shoji, Takahiro Kashiwagi, Yusuke Torikoshi, Yasuo Miura, Daniel G Tenen, Taira Maekawa
The transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) is highly expressed in monocytes/macrophages. However, its roles in monopoiesis are largely unknown. Here, we investigated the roles of C/EBPβ in monopoiesis. Further subdivision of monocytes revealed that Cebpb mRNA was highly upregulated in Ly6C(-) monocytes in bone marrow. Accordingly, Ly6C(-) monocytes were significantly reduced in Cebpb(-/-) mice. Bone marrow chimera experiments and Mx1-Cre-mediated deletion of Cebpb revealed the cell-intrinsic and monocyte-specific requirement for C/EBPβ in monopoiesis...
August 14, 2017: Blood
https://www.readbyqxmd.com/read/28800589/prognostic-factors-and-outcomes-in-japanese-lung-transplant-candidates-with-interstitial-lung-disease
#7
Kohei Ikezoe, Tomohiro Handa, Kiminobu Tanizawa, Toyofumi F Chen-Yoshikawa, Takeshi Kubo, Akihiro Aoyama, Hideki Motoyama, Kyoko Hijiya, Shinsaku Tokuda, Yoshinari Nakatsuka, Yuko Yamamoto, Ayako Oshima, Shin-Ichi Harashima, Sonoko Nagai, Toyohiro Hirai, Hiroshi Date, Kazuo Chin
OBJECTIVE: Young patients with advanced interstitial lung disease (ILD) are potential candidates for cadaveric lung transplantation. This study aimed to examine clinical features, outcomes, and prognostic factors in Japanese ILD patients awaiting lung transplantation. METHODS: We investigated the clinical features and outcomes of 77 consecutive candidates with ILD who were referred to Kyoto University Hospital and subsequently actively listed for lung transplant in the Japan Organ Transplant Network between 2010 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28800285/cytogenetic-reconstruction-of-gamma-ray-doses-delivered-to-atomic-bomb-survivors-dealing-with-wide-distributions-of-photon-energies-and-contributions-from-hematopoietic-stem-progenitor-cells
#8
Nori Nakamura, Yuko Hirai, Yoshiaki Kodama, Kanya Hamasaki, Harry M Cullings, Kismet A Cordova, Akio Awa
Retrospective estimation of the doses received by atomic bomb (A-bomb) survivors by cytogenetic methods has been hindered by two factors: One is that the photon energies released from the bomb were widely distributed, and since the aberration yield varies depending on the energy, the use of monoenergetic (60)Co gamma radiation to construct a calibration curve may bias the estimate. The second problem is the increasing proportion of newly formed lymphocytes entering into the lymphocyte pool with increasing time intervals since the exposures...
August 11, 2017: Radiation Research
https://www.readbyqxmd.com/read/28797429/early-procedural-and-health-status-outcomes-after-chronic-total-occlusion%C3%A2-angioplasty-a-report-from-the-open-cto-registry-outcomes-patient-health-status-and-efficiency-in-chronic-total-occlusion-hybrid-procedures
#9
James Sapontis, Adam C Salisbury, Robert W Yeh, David J Cohen, Taishi Hirai, William Lombardi, James M McCabe, Dimitri Karmpaliotis, Jeffrey Moses, William J Nicholson, Ashish Pershad, R Michael Wyman, Anthony Spaedy, Stephen Cook, Parag Doshi, Robert Federici, Craig R Thompson, Steven P Marso, Karen Nugent, Kensey Gosch, John A Spertus, J Aaron Grantham
OBJECTIVES: This study sought to accurately describe the success rate, risks, and patient-reported benefits of contemporary chronic total occlusion (CTO) percutaneous coronary intervention (PCI). BACKGROUND: In light of the evolving techniques to successfully revascularize CTO lesions, there remains a compelling need to more accurately quantify the success rates, risks, and benefits of these complex procedures. METHODS: Using a uniquely comprehensive, core-lab adjudicated, single-arm, multicenter registry of 1,000 consecutive patients undergoing CTO PCI by the hybrid approach, we evaluated the technical success rates, complication rates, and raw and adjusted health status benefits at 1 month among successfully as compared to unsuccessfully treated patients...
August 14, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28795244/a-retrospective-study-on-the-risk-factors-for-bleeding-events-in-warfarin-therapy-focusing-on-renal-function
#10
Toshinori Hirai, Yukihiro Hamada, Yujiro Geka, Shiori Kuwana, Koji Hirai, Mai Ishibashi, Yutaka Fukaya, Toshimi Kimura
PURPOSE: The anticoagulant effect of warfarin used to treat stroke has been shown to vary with the concomitant use of medications and comorbidity. Concomitant use of antithrombotic drugs and underlying chronic kidney disease (CKD) represent risk factors for bleeding events. We conducted a comprehensive investigation of the background characteristics and concomitant use of drugs to identify the risk factors for warfarin-related bleeding, focusing on renal function. METHODS: The study population consisted of patients prescribed warfarin at the Tokyo Women's Medical University Hospital...
August 9, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28791864/melting-of-oxygen-vacancy-order-at-oxide-heterostructure-interface
#11
Kei Hirai, Ryotaro Aso, Yusuke Ozaki, Daisuke Kan, Mitsutaka Haruta, Noriya Ichikawa, Hiroki Kurata, Yuichi Shimakawa
Modifications of oxygen coordination environments in heterostructures consisting of dissimilar oxides often emerge and lead to unusual properties of the constituent materials. While lots of attention has been paid on slight modifications of rigid oxygen octahedra of perovskite-based heterointerfaces, revealing the modification behaviors of the oxygen coordination environments in the heterostructures containing oxides with oxygen vacancies has been challenging. Here we show that a significant modification of oxygen coordination environments -melting of oxygen vacancy order- is induced at the heterointerface between SrFeO2...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28790256/-safe-handling-of-hazardous-drugs-in-nursing-practice
#12
Kazue Hirai
Handling of hazardous drugs in nursing practice, there are risks of a wide variety of occupational exposures such as drug administration, management of spills, care of patients after administration, etc. Using a general infusion set for intravenous administration, there are risk of exposure such as scattering when the bottle needle is spiked into the infusion bag, leakage when priming the infusion line with antineoplastic drug, spillage when removing the side tube. For intravenous administration, use of CSTD for administration is most effective, but in many facilities, a general infusion set is used due to cost considerations...
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28783208/possible-case-of-halogen-bond-driven-self-disproportionation-of-enantiomers-sde-via-achiral-chromatography
#13
Vadim Anatolievich Soloshonok, Shumpei Terada, Motohiro Hirai, Ayaka Honzawa, Osamu Kitagawa, Angelika Kamizela, Alicja Wzorek
The major breakthrough reported in this work is the discovery of likely halogen bond-driven self-disproportionation of enantiomers (SDE). Taking into account that the halogen bonding interactions can be rationally designed and can match, or even exceed, the strength of the more familiar hydrogen bond, this discovery clearly opens an unexpected new direction of research in the areas of molecular chirality and the SDE phenomenon.
August 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28783092/interaction-between-various-apple-procyanidin-and-staphylococcal-enterotoxin-a-and-their-inhibitory-effects-on-toxin-activity
#14
Yuko Shimamura, Chikako Hirai, Yuka Sugiyama, Mio Utsumi, Akio Yanagida, Masatsune Murata, Norio Ohashi, Shuichi Masuda
In this study, we investigated the interaction between apple polyphenols (AP; mainly consisting of procyanidin (PC) from an apple) and staphylococcal enterotoxin A (SEA), and the inhibitory effects of AP on SEA activity. According to the degree of polymerization, in particularly highly polymerized PC (more than pentamer) strongly interacted with SEA. The binding affinity of AP with SEA molecules was determined using Biacore analysis. AP reacted with SEA immobilized on a Biacore sensor chip. After treatment with pepsin and pancreatin, to examine the changes of binding affinity of AP in intragastric conditions, AP maintained interaction with SEA...
August 7, 2017: Toxins
https://www.readbyqxmd.com/read/28781805/successful-oral-desensitization-with-crizotinib-after-crizotinib-induced-hepatitis-in-an-anaplastic-lymphoma-kinase-rearranged-non-small-cell-lung-cancer-patient-a-case-report
#15
Yuto Yasuda, Yasuyo Nishikawa, Yuichi Sakamori, Makoto Terao, Kentaro Hashimoto, Tomoko Funazo, Takashi Nomizo, Takahiro Tsuji, Hironori Yoshida, Hiroki Nagai, Hiroaki Ozasa, Toyohiro Hirai, Young Hak Kim
Crizotinib is one of the molecularly-targeted agents targeted against anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC). Although its effects appear to be promising, crizotinib may cause adverse effects in patients with ALK-rearranged NSCLC. Hepatic laboratory abnormalities are frequently observed with crizotinib and treatment discontinuation is occasionally required. We herein report the case of a 51-year-old woman diagnosed with relapsed ALK-rearranged NSCLC, who received crizotinib as second-line systemic chemotherapy...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28777806/claudin-4-knockout-by-talen-mediated-gene-targeting-in-mdck-cells-claudin-4-is-dispensable-for-the-permeability-properties-of-tight-junctions-in-wild-type-mdck-cells
#16
Shinsaku Tokuda, Toyohiro Hirai, Mikio Furuse
Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability. Claudin-4 was the first claudin whose involvement in the TJ permeability in cultured cells was directly demonstrated, but the permeability properties of individual claudins including claudin-4 are still incompletely clarified. In this study, we established claudin-4 knockout cells using transcription activator-like effector nucleases (TALENs), a recently developed method for genome editing, and investigated the permeability property of claudin-4 in MDCK II cells...
2017: PloS One
https://www.readbyqxmd.com/read/28773945/application-of-a-loop-type-laboratory-biofilm-reactor-to-the-evaluation-of-biofilm-for-some-metallic-materials-and-polymers-such-as-urinary-stents-and-catheters
#17
Hideyuki Kanematsu, Hikonaru Kudara, Shun Kanesaki, Takeshi Kogo, Hajime Ikegai, Akiko Ogawa, Nobumitsu Hirai
A laboratory biofilm reactor (LBR) was modified to a new loop-type closed system in order to evaluate novel stents and catheter materials using 3D optical microscopy and Raman spectroscopy. Two metallic specimens, pure nickel and cupronickel (80% Cu-20% Ni), along with two polymers, silicone and polyurethane, were chosen as examples to ratify the system. Each set of specimens was assigned to the LBR using either tap water or an NB (Nutrient broth based on peptone from animal foods and beef extract mainly)-cultured solution with E-coli formed over 48-72 h...
October 11, 2016: Materials
https://www.readbyqxmd.com/read/28771766/impact-of-coxsackievirus-a6-emergence-on-hand-foot-and-mouth-disease-epidemic-in-osaka-city-japan
#18
Daiki Kanbayashi, Atsushi Kaida, Seiji P Yamamoto, Yuki Hirai, Hideyuki Kubo, Ryoko Fujimori, Noritaka Hakui, Hidetetsu Hirokawa, Nobuhiro Iritani
Hand, foot, and mouth disease (HFMD) is an acute febrile illness characterized by fever; sore throat; and vesicular eruptions on the hands, feet, and oral mucosa. Until 2010, HFMD was predominantly associated with enterovirus (EV) A71 and coxsackievirus (CV) A16 in Japan. In 2011, CV-A6 emerged as a primary causative agent, causing the largest HFMD epidemic in Japan since 1981. Since then, CV-A6 has caused large HFMD epidemics every 2 years. The phylogenetic analysis of complete Viral Protein 1 (VP1) sequences revealed that most CV-A6 strains detected from 2011 to 2015 in Osaka City were classified into a different clade compared with CV-A6 strains detected from 1999 until 2009...
August 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28768977/the-first-case-of-pseudomonas-aeruginosa-bacteremic-pneumonia-in-a-cancer-patient-receiving-pegfilgrastim
#19
Fujiko Morita, Yuji Hirai, Kiyozumi Suzuki, Yuki Uehara, Kazunori Mitsuhashi, Masahito Takahashi, Sumio Watanabe, Toshio Naito
A single dose of pegfilgrastim or the daily administration of colony-stimulating factors can be used to prevent febrile neutropenia. This may delay the detection of rapidly progressive infections among cancer patients undergoing chemotherapy. We report a case of Pseudomonas aeruginosa bacteremic pneumonia that occurred in a patient receiving pegfilgrastim.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28768933/7-hydroxy-3-methyleneisoindolin-1-one-as-a-new-esipt-fluorescent-probe-to-monitor-aqueous-environments
#20
Yusuke Kimuro, Kazuteru Usui, Satoru Karasawa, Go Hirai, Mariko Aso
A 7-hydroxy derivative of 3-methyleneisoindolin-1-one 1 was synthesized and its properties as a new fluorophore undergoing excited-state intramolecular proton transfer (ESIPT) were investigated. In alcohols and dimethylsulfoxide, 1 exhibited dual emission at ca. 380 and 525-540 nm when excited at ca. 336 nm, which agreed well with the density functional theory (DFT) and time-dependent (TD)-DFT-calculated emission predictions of 1 and its ESIPT tautomer. In aqueous solutions at near neutral pH, 1 exhibited a broad emission band at ca...
2017: Chemical & Pharmaceutical Bulletin
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