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https://www.readbyqxmd.com/read/28628935/proximal-left-main-bronchus-resection-reconstruction-through-left-thoracotomy-with-tracheal-traction
#1
Naoko Imanishi, Masaru Takenaka, Ayako Hirai, Fumihiro Tanaka
No abstract text is available yet for this article.
June 19, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28626037/autopolyploidization-geographic-origin-and-metabolome-evolution-in-arabidopsis-thaliana
#2
Fredd Vergara, Bart Rymen, Ayuko Kuwahara, Yuji Sawada, Muneo Sato, Masami Y Hirai
PREMISE OF THE STUDY: Autopolyploidy, or whole-genome duplication, is a recurrent phenomenon in plant evolution. Its existence can be inferred from the presence of massive levels of genetic redundancy revealed by comparative plant phylogenomics. Whole-genome duplication is theoretically associated with evolutionary novelties such as the development of new metabolic reactions and therefore contributes to the evolution of new plant metabolic profiles. However, very little is yet known about the impact of autopolyploidy on the metabolism of recently formed autopolyploids...
June 16, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28619623/intracellular-trafficking-of-particles-inside-endosomal-vesicles-is-regulated-by-particle-size
#3
Michihiko Aoyama, Yasuo Yoshioka, Yoshiyuki Arai, Haruna Hirai, Rio Ishimoto, Kazuya Nagano, Kazuma Higashisaka, Takeharu Nagai, Yasuo Tsutsumi
Little comparative information is available on the detailed intracellular dynamics (diffusion, active movement, and distribution mechanisms) of nanoparticles (≤100nm) and sub-micron particles (>100nm). Here, we quantitatively examined the intracellular movements of different-sized particles and of the endosomal vesicles containing those particles. We showed that silica nanoparticles of various sizes (30 to 100nm) had greater motility than sub-micron particles in A549 cells. Although particles of different sizes localized in the early endosomes, late endosomes, and lysosomes in different proportions, their motilities did not vary, regardless of the vesicles in which they were localized...
June 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28615699/novel-regulatory-mechanism-of-serine-biosynthesis-associated-with-3-phosphoglycerate-dehydrogenase-in-arabidopsis-thaliana
#4
Eiji Okamura, Masami Yokota Hirai
The proteinogenic amino acid L-serine is a precursor for various essential biomolecules in all organisms. 3-Phosphoglycerate dehydrogenase (PGDH) is the first committed enzyme of the phosphorylated pathway of L-serine biosynthesis, and is regulated by negative feedback from L-serine in bacteria and plants. In the present study, two Arabidopsis PGDH isoforms were inhibited by L-serine but were activated by L-amino acids such as L-homocysteine in vitro. Activation and inhibition by these amino acids was cooperative, suggesting an allosteric mechanism...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614282/clinical-outcomes-of-cervical-spinal-surgery-for-cervical-myelopathic-patients-with-coexisting-lumbar-spinal-canal-stenosis-tandem-spinal-stenosis-a-retrospective-analysis-of-297-cases
#5
Tsuyoshi Yamada, Toshitaka Yoshii, Naoki Yamamoto, Takashi Hirai, Hiroyuki Inose, Tsuyoshi Kato, Shigenori Kawabata, Atsushi Okawa
STUDY DESIGN: Retrospective observational study. OBJECTIVE: We evaluated the prevalence and clinical characteristics of tandem spinal stenosis (TSS) in patients with cervical myelopathy including ossification of the posterior longitudinal ligament of the cervical spine (C-OPLL). SUMMARY OF BACKGROUND DATA: Concurrent cervical and lumbar spinal canal stenosis is generally reported as TSS. Most previous studies have used magnetic resonance imaging to evaluate spinal stenosis in the cervical and lumbar spine...
June 13, 2017: Spine
https://www.readbyqxmd.com/read/28611388/aberrant-plasticity-of-peripheral-sensory-axons-in-a-painful-neuropathy
#6
Takashi Hirai, Yatendra Mulpuri, Yanbing Cheng, Zheng Xia, Wei Li, Supanigar Ruangsri, Igor Spigelman, Ichiro Nishimura
Neuronal cells express considerable plasticity responding to environmental cues, in part, through subcellular mRNA regulation. Here we report on the extensive changes in distribution of mRNAs in the cell body and axon compartments of peripheral sensory neurons and the 3' untranslated region (3'UTR) landscapes after unilateral sciatic nerve entrapment (SNE) injury in rats. Neuronal cells dissociated from SNE-injured and contralateral L4 and L5 dorsal root ganglia were cultured in a compartmentalized system. Axonal and cell body RNA samples were separately subjected to high throughput RNA sequencing (RNA-Seq)...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606572/effect-of-dietary-fatty-acid-and-micronutrient-intake-energy-ratio-on-serum-diamine-oxidase-activity-in-healthy-women
#7
Makoto Miyoshi, Manami Ueno, Mari Matsuo, Yasuhiro Hamada, Michiko Takahashi, Masashi Yamamoto, Ikuko Yamamoto, Reiko Mikajiri, Satoko Tabuchi, Kumiko Wakida, Misa Yamanishi, Midori Hirai, Makoto Usami
OBJECTIVE: Serum diamine oxidase (DAO) activity varies to a greater extent in women than in men. DAO activity during the luteal phase was higher than that during the follicular phase in healthy women. Recent reports have indicated that duodenal lipid infusion increased DAO activity in the intestinal lymph in rats. The aim of this study was to elucidate the effect of dietary nutrient intake on serum DAO activity in healthy women. METHODS: Thirty-four healthy Japanese women were recruited...
July 2017: Nutrition
https://www.readbyqxmd.com/read/28604288/laparoendoscopic-single-site-nephrectomy-for-hemodialysis-patients-with-dialysis-related-renal-tumors
#8
Kohei Takei, Mutsushi Yamasaki, Satoki Abe, Naoyuki Yamanaka, Shinya Sejiyama, Takahiro Narimatsu, Shinro Hata, Tadamasa Shibuya, Kenichi Hirai, Tadasuke Ando, Toshitaka Shin, Kenichi Mori, Yasuhiro Sumino, Takeo Nomura, Fuminori Sato, Toshiro Terachi, Hiromitsu Mimata
PURPOSE: The purpose of this study is to assess the efficacy of laparoendoscopic single-site (LESS) nephrectomy in hemodialysis patients, we compared outcomes between LESS nephrectomy and conventional laparoendoscopic nephrectomy in hemodialysis patients with dialysis-related renal tumors. MATERIAL AND METHODS: A total of 16 hemodialysis patients who underwent LESS nephrectomy (LESS-N; n = 8) or conventional laparoendoscopic nephrectomy (C-N; n = 8) between November 2003 and July 2012 were retrospectively evaluated...
June 12, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28594044/quantum-tunneling-injection-of-hot-electrons-in-au-tio2-plasmonic-photocatalysts
#9
Yasuhiro Shiraishi, Naoki Yasumoto, Jun Imai, Hirokatsu Sakamoto, Shunsuke Tanaka, Satoshi Ichikawa, Bunsho Ohtani, Takayuki Hirai
Visible light absorption of plasmonic Au nanoparticles supported on semiconductor TiO2 leads to injection of their photoactivated "hot electrons (ehot(-))" into the TiO2 conduction band. This charge separation facilitates several oxidation and reduction reactions. These plasmonic systems, however, suffer from low quantum yields because the Schottky barrier created at the Au-TiO2 interface suppresses ehot(-) injection. Here we report that Au nanoparticles supported on the anatase particles isolated from Degussa (Evonik) P25 TiO2 promote ehot(-) injection with much higher efficiency than those supported on other commercially-available TiO2 and catalyze aerobic oxidation with very high quantum yield (7...
June 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/28591282/incidence-of-anterior-segment-neovascularization-during-intravitreal-treatment-for-macular-edema-secondary-to-central-retinal-vein-occlusion
#10
Luiz Filipe Adami Lucatto, Octaviano Magalhães-Junior, Juliana M B Prazeres, Adriano M Ferreira, Ramon A Oliveira, Nilva S Moraes, Flávio E Hirai, Mauricio Maia
Purpose: To analyze the effects of injections of intravitreal triamcinolone acetonide (IVTA) and intravitreal bevacizumab (IVB) on the incidence rates of anterior segment neovascularization (ASN) and neovascular glaucoma (NVG) in patients with macular edema secondary to central retinal vein occlusion (CRVO). Methods: In this prospective, randomized, double-masked, sham-controlled study, 35 patients with macular edema following CRVO were randomized to intravitreal bevacizumab, intravitreal triamcinolone acetonide, or sham injections during the first 6 months of the study...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28591280/keratoconus-progression-is-not-inhibited-by-reducing-eyelid-muscular-force-with-botulinum-toxin-a-treatment-a-randomized-trial
#11
Adimara da Candelaria Renesto, Teissy Hentona Osaki, Midori Hentona Osaki, Flávio E Hirai, Mauro Campos
Purpose: To evaluate whether reducing eyelid muscular force through the administration of botulinum toxin type A (BTX-A) to the orbicularis oculi muscles of patients with keratoconus affected corneal parameters indicative of disease progression. Methods: In this prospective parallel randomized clinical trial, 40 eyes of 40 patients with keratoconus were randomized into equally sized control and BTX-A groups. Patients in the BTX-A group received subcutaneous BTX-A injections into the orbicularis muscle...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28589481/surgical-case-of-isolated-pulmonary-valve-endocarditis-in-a-patient-without-predisposing-factors
#12
Kyohei Hatori, Satoshi Ohki, Tamiyuki Obayashi, Kiyomitsu Yasuhara, Hanako Hirai, Takao Miki
We report a case of isolated pulmonary valve endocarditis in a 47-year-old woman without predisposing factors. She had episodes of low-grade fever and non-productive cough and was initially diagnosed with bacterial pneumonia. With antibiotic treatment, her condition improved transiently, but she had repeated respiratory events. Forty days after her first visit, she complained of severe dyspnea. Echocardiography revealed a large vegetation adhering to the pulmonary valve and she was diagnosed with isolated pulmonary valve endocarditis...
June 6, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28588734/plasma-t790m-and-hgf-as-potential-predictive-markers-for-egfr-tki-re-challenge
#13
Tomomi Nakamura, Naomi Watanabe, Akemi Sato, Kazutoshi Komiya, Hitomi Umeguchi, Toshiya Hosomi, Mitsuharu Hirai, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane
Re-challenge with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) has been suggested to potentially improve survival in certain populations of patients with advanced lung cancer, but predictive markers for the success of EGFR-TKI re-challenge have not been identified. The present study analyzed 16 re-challenges with EGFR-TKI undertaken in 12 patients with lung adenocarcinoma by investigating T790M and hepatocyte growth factor (HGF) in plasma coupled with clinical characteristics. EGFR mutations in plasma DNA were detected using the wild inhibiting PCR and quenched probe system for exon 19 deletions, and T790M and L858R were detected using the mutation-biased PCR and quenched probe system...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28582663/molecular-and-epidemiological-characterization-of-staphylococcal-foodborne-outbreak-of-staphylococcus-aureus-harboring-seg-sei-sem-sen-seo-and-selu-genes-without-production-of-classical-enterotoxins
#14
Kaoru Umeda, Hiromi Nakamura, Kaori Yamamoto, Nobuko Nishina, Kiyoshi Yasufuku, Yuki Hirai, Teruo Hirayama, Kaoru Goto, Atsushi Hase, Jun Ogasawara
Staphylococcal food poisoning is the result of consumption of food contaminated with staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus. To date, 23 SEs and SE-like enterotoxins (SEls) have been described in the literature. They are divided into classical SEs (SEA-SEE) and new SE/SEls (SEG-SElX). Some have proved to be foodborne-inducible, but others remain unidentified. In May 2016, at an elderly group home in Osaka city, Japan, an outbreak from foodborne pathogens occurred among lunch party participants...
May 30, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28582593/secreted-protein-acidic-and-rich-in-cysteine-functions-in-colitis-via-il17a-regulation-in-mucosal-cd4-t-cells
#15
Makoto Tanaka, Tomohisa Takagi, Yuji Naito, Kazuhiko Uchiyama, Yuma Hotta, Yuki Toyokawa, Chihiro Ushiroda, Yasuko Hirai, Wataru Aoi, Yasuki Higashimura, Katsura Mizushima, Tetsuya Okayama, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Yoshito Itoh
BACKGROUND AND AIM: Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycol that regulates cell proliferation, tissue repair, and tumorigenesis. Despite evidence linking SPARC to inflammation, the mechanisms are unclear. Accordingly, the role of SPARC in intestinal inflammation was investigated. METHODS: Colitis was induced in wild-type (WT) and SPARC knockout (KO) mice using trinitrobenzene sulfonic acid (TNBS). Colons were assessed for damage, leukocyte infiltration, Tnf, Ifng, Il17a, and Il10 mRNA expression, and histology...
June 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28575846/clinical-impact-of-high-serum-hepatocyte-growth-factor-in-advanced-non-small-cell-lung-cancer
#16
Takahiro Tsuji, Yuichi Sakamori, Hiroaki Ozasa, Yoshitaka Yagi, Hitomi Ajimizu, Yuto Yasuda, Tomoko Funazo, Takashi Nomizo, Hironori Yoshida, Hiroki Nagai, Ken Maeno, Tetsuya Oguri, Toyohiro Hirai, Young Hak Kim
Activation of c-MET through hepatocyte growth factor (HGF) increases tumorigenesis, induces resistance, and is associated with poor prognosis in various solid tumors. However, the clinical value of serum HGF (sHGF) in patients with advanced non-small cell lung cancer (NSCLC), especially those receiving cytotoxic chemotherapy, remains unknown. Here, we show that sHGF may be useful to predict tumor response and progression-free survival (PFS) in patients with advanced NSCLC. A total of 81 patients with NSCLC were investigated...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28572534/contrast-media-enhancement-reduction-predicts-tumor-response-to-presurgical-molecular-targeting-therapy-in-patients-with-advanced-renal-cell-carcinoma
#17
Shogo Hosogoe, Shingo Hatakeyama, Ayumu Kusaka, Itsuto Hamano, Yoshimi Tanaka, Kazuhisa Hagiwara, Hideaki Hirai, Satoko Morohashi, Hiroshi Kijima, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Chikara Ohyama
BACKGROUND AND OBJECTIVE: A quantitative tumor response evaluation to molecular-targeting agents in advanced renal cell carcinoma (RCC) is debatable. We aimed to evaluate the relationship between radiologic tumor response and pathological response in patients with advanced RCC who underwent presurgical therapy. RESULTS: Of 34 patients, 31 underwent scheduled radical nephrectomy. Presurgical therapy agents included axitinib (n = 26), everolimus (n = 3), sunitinib (n = 1), and axitinib followed by temsirolimus (n = 1)...
May 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28566663/promising-therapies-for-fungal-infection-based-on-the-study-to-elucidate-mechanisms-to-cope-with-stress-in-candida-species-translated-article
#18
Kazuyuki Hirai, Tatsuya Inukai, Hironobu Nakayama
In recent years, the incidence of fungal infections has been increasing, particularly among patients with immune systems compromised by human immunodeficiency virus infection, organ transplantation, and/or chemotherapy for cancer. Current therapies for treating systemic fungal infection have limited effectiveness and have created problems of adverse reactions and drug resistance. These issues therefore motivate us to develop novel antifungals. Elucidation of stress response mechanisms and virulence factors in pathogenic fungi is required in developing an effective antifungal strategy...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28566608/a-rare-case-of-adult-autoimmune-neutropenia-successfully-treated-with-prednisolone
#19
Mari Fujita, Hiroshi Kawabata, Tomomi Oka, Masakatsu Hishizawa, Toshiyuki Kitano, Tadakazu Kondo, Kohei Yamashita, Kimiko Yurugi, Hideyo Hirai, Taira Maekawa, Akifumi Takaori-Kondo
Autoimmune neutropenia (AIN) is a rare disorder that may cause life-threatening infections. In adults, most cases are secondary to other pathological conditions, and primary AIN is extremely rare. We herein report a case involving a 57-year-old woman diagnosed with AIN. A granulocyte immunofluorescence test detected autoantibodies against human neutrophil antigens in her serum, while various examinations revealed no other causes of neutropenia, suggesting her AIN was primary. She was refractory to granulocyte-colony-stimulating factor but responded to prednisolone...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28559914/changes-in-cerebral-oxygenation-associated-with-intradialytic-blood-transfusion-in-patients-with-severe-anemia-undergoing-hemodialysis
#20
Kiyonori Ito, Susumu Ookawara, Yuichiro Ueda, Haruhisa Miyazawa, Masaya Kofuji, Hideyuki Hayasaka, Takayuki Uchida, Katsunori Yanai, Hiroki Ishii, Mitsutoshi Shindo, Taisuke Kitano, Keiji Hirai, Yoshio Kaku, Taro Hoshino, Kaoru Tabei, Yoshiyuki Morishita
BACKGROUND: Hemodialysis (HD) patients frequently suffer from severe anemia caused by various hemorrhagic disorders in addition to renal anemia. Intradialytic blood transfusion is sometimes performed; however, the cerebral oxygenation changes associated with this procedure remain unclear. METHODS: Sixteen HD patients with severe anemia who required intradialytic blood transfusion were included (12 men and 4 women; mean age, 64.8 ± 9.8 years). Cerebral regional oxygen saturation (rSO2) was monitored using near-infrared spectroscopy, and cerebral fractional oxygen extraction (FOE) was calculated before and after HD...
January 2017: Nephron Extra
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