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https://www.readbyqxmd.com/read/28445192/one-year-clinical-outcomes-of-a-corneal-inlay-for-presbyopia
#1
Sandra M C Beer, Rodrigo Santos, Eliane M Nakano, Flavio Hirai, Enrico J Nitschke, Claudia Francesconi, Mauro Campos
PURPOSE: To report the results of a 1-year follow-up analysis of the safety and efficacy of the Flexivue Microlens corneal inlay. METHODS: The Flexivue Microlens corneal inlay was implanted in the nondominant eye of patients with emmetropic presbyopia (a spherical equivalent of -0.5 to 1.00 diopter) after the creation of a 300-μm deep stromal pocket, using a femtosecond laser. The patients were followed up according to a clinical protocol involving refraction, anterior segment imaging analysis (Oculyzer), and optical quality analysis (OPD-Scan)...
April 25, 2017: Cornea
https://www.readbyqxmd.com/read/28444357/coordinated-regulations-of-mrna-synthesis-and-decay-during-cold-acclimation-in-arabidopsis-cells
#2
Toshihiro Arae, Shiori Isai, Akira Sakai, Katsuhiko Mineta, Masami Yokota Hirai, Yuya Suzuki, Shigehiko Kanaya, Junji Yamaguchi, Satoshi Naito, Yukako Chiba
Plants possess a cold acclimation system to acquire freezing tolerance through pre-exposure to non-freezing low temperatures. The transcriptional cascade of C-repeat binding factors (CBFs)/dehydration response element-binding factors (DREBs) is considered a major transcriptional regulatory pathway during cold acclimation. However, little is known regarding the functional significance of mRNA stability regulation in the response of gene expression to cold stress. The actual level of individual mRNAs is determined by a balance between mRNA synthesis and degradation...
April 21, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28443854/infrared-laser-writing-of-mofs
#3
K Hirai, K Sada
An infrared (IR) laser machine is used for the synthesis of metal-organic frameworks (MOFs). Solutions containing metal ions and organic ligands are casted on glass substrates. MOF crystals are formed at the positions the IR laser irradiated, resulting in the patterning of MOFs.
April 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28441937/observation-of-zn-photoprotoporphyrin-red-autofluorescence-in-human-bronchial-cancer-using-color-fluorescence-endoscopy
#4
Yoshinobu Ohsaki, Takaaki Sasaki, Satoshi Endo, Masahiro Kitada, Shunsuke Okumura, Noriko Hirai, Yoshihiro Kazebayashi, Eri Toyoshima, Yasushi Yamamoto, Kaneyoshi Takeyama, Susumu Nakajima, Isao Sakata
BACKGROUND: We observed red autofluorescence emanating from bronchial cancer lesions using a sensitive color-fluorescence endoscopy system. We investigated to clarify the origin of the red autofluorescence. METHODS: The wavelengths of the red autofluorescence emanating from lesions were measured in eight patients using a spectrum analyzer and compared based on pathologic findings. Red autofluorescence at 617.3, 617.4, 619.0, and 617.1 nm was emitted by normal bronchus, inflamed tissue, tissue exhibiting mild dysplasia, and malignant lesions, respectively...
April 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28434900/breast-cancer-in-a-pectoralis-major-myocutaneous-flap-used-for-the-reconstruction-of-tongue-cancer-a-case-report
#5
Eiji Hirai, Shunji Sarukaw, Kozo Yamamoto, Masahiro Okamoto
Breast cancers are the most common cancers in women. However, breast cancer occurring in a pectoralis major myocutaneous flap is extremely rare. This article describes a case of breast cancer occurring in such a flap used for reconstruction of the tongue in a 72-year-old woman. Follow-up computed tomogram depicted a slowly growing mass in the flap. Thirty-nine months postoperatively, a fine-needle aspiration biopsy specimen taken from the lesion suggested glandular carcinoma. The patient was diagnosed with breast cancer in the neck area of the flap and tumor excision was performed...
March 29, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28433633/angiotensin-converting-enzyme-2-is-a-potential-therapeutic-target-for-egfr-mutant-lung-adenocarcinoma
#6
Miki Yamaguchi, Sachie Hirai, Toshiyuki Sumi, Yusuke Tanaka, Makoto Tada, Yukari Nishii, Tadashi Hasegawa, Hiroaki Uchida, Gen Yamada, Atsushi Watanabe, Hiroki Takahashi, Yuji Sakuma
EGFR-mutant lung adenocarcinomas contain a subpopulation of cells that have undergone epithelial-to-mesenchymal transition and can grow independently of EGFR. To kill these cancer cells, we need a novel therapeutic approach other than EGFR inhibitors. If a molecule is specifically expressed on the cell surface of such EGFR-independent EGFR-mutant cancer cells, it can be a therapeutic target. We found that a mesenchymal EGFR-independent subline derived from HCC827 cells, an EGFR-mutant lung adenocarcinoma cell line, expressed angiotensin-converting enzyme 2 (ACE2) to a greater extent than its parental cells...
April 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28431933/caspofungin-versus-micafungin-in-the-incidence-of-hepatotoxicity-in%C3%A2-patients-with-normal-to-moderate-liver-failure
#7
Yuichi Shibata, Mao Hagihara, Hideo Kato, Noriyo Kawasumi, Jun Hirai, Naoya Nishiyama, Nobuhiro Asai, Yusuke Koizumi, Yuka Yamagishi, Katsuhiko Matsuura, Hiroshige Mikamo
BACKGROUND: One of the major adverse events of caspofungin and micafungin is hepatotoxicity, however, there are few reports compared the incidence of hepatotoxicity between caspofungin and micafungin. Herein, the primary objective of this study was to compare the incidence of hepatotoxicity between caspofungin and micafungin treatments for patients with fungal or suspected fungal infection. METHODS: In total, 201 patients [caspofungin group: 66 patients; micafungin group: 135 patients] treated with echinocandins from April 2014 to November 2015 at Aichi Medical University Hospital...
April 18, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28427749/a-clinical-method-for-detecting-bronchial-reversibility-using-a-breath-sound-spectrum-analysis-in-infants
#8
Mayumi Enseki, Mariko Nukaga, Hideyuki Tabata, Kota Hirai, Shinichi Matsuda, Hiroyuki Mochizuki
BACKGROUND: Using a breath sound analyzer, we investigated clinical parameters for detecting bronchial reversibility in infants. METHODS: A total of 59 infants (4-39 months, mean age 7.8 months) were included. In Study 1, the intra- and inter-observer variability was measured in 23 of 59 infants. Breath sound parameters, the frequency at 99% of the maximum frequency (F99), frequency at 25%, 50%, and 75% of the power spectrum (Q25, Q50, and Q75), and highest frequency of inspiratory breath sounds (HFI), and parameters obtained using the ratio of parameters, i...
May 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28421832/experimental-induction-of-chicken-aa-amyloidosis-in-white-layer-chickens-by-inoculation-with-inactivated-vaccines
#9
Wazir Ahmad Habibi, Takuya Hirai, Mohammad Hakim Niazmand, Naoko Okumura, Ryoji Yamaguchi
We investigated the amyloidogenic potential of inactivated vaccines and the localized production of serum amyloid A (SAA) at the injection site in white layer chickens. Hens in the treated group were injected intramuscularly three times with high doses of inactivated oil-emulsion Salmonella Enteritidis vaccine and multivalent viral and bacterial inactivated oil-emulsion vaccines at two week intervals. Chickens in the control group did not receive any inoculum. In the treated group, emaciation, and granulomas were present, while several chickens died between 4-6 weeks after the first injection...
April 19, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28421741/uphill-water-transport-on-a-wettability-patterned-surface-experimental-and-theoretical-results
#10
Yuji Hirai, Hiroyuki Mayama, Yasutaka Matsuo, Masatsugu Shimomura
In nature, there exist a number of functional water-controlling surfaces, such as the water-repellent surface of lotus leaves, the superhydrophobic water-adhesive surface of rose petals, the water-harvesting surface of a beetle's back, and the water-transporting surface of the legs of Ligia exotica. These natural surfaces suggest that surface chemistry and hierarchical structures are essential for controlling water behavior. We have reported the preparation of superhydrophobic and anti-reflection silicon nanospike-array structures using self-organized honeycomb-patterned films as 3D dry etching masks...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28421077/human-scavenger-receptor-a1-mediated-inflammatory-response-to-silica-particle-exposure-is-size-specific
#11
Nobuo Nishijima, Toshiro Hirai, Kazuki Misato, Michihiko Aoyama, Etsushi Kuroda, Ken J Ishii, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi
The application of nanotechnology in the health care setting has many potential benefits; however, our understanding of the interactions between nanoparticles and our immune system remains incomplete. Although many of the biological effects of nanoparticles are negatively correlated with particle size, some are clearly size specific and the mechanisms underlying these size-specific biological effects remain unknown. Here, we examined the pro-inflammatory effects of silica particles in THP-1 cells with respect to particle size; a large overall size range with narrow intervals between particle diameters (particle diameter: 10, 30, 50, 70, 100, 300, and 1,000 nm) was used...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420812/isolation-of-mesenchymal-stromal-stem-cells-from-cryopreserved-umbilical-cord-blood-cells
#12
Sumie Fujii, Yasuo Miura, Masaki Iwasa, Satoshi Yoshioka, Aya Fujishiro, Noriko Sugino, Hitomi Kaneko, Yoko Nakagawa, Hideyo Hirai, Akifumi Takaori-Kondo, Tatsuo Ichinohe, Taira Maekawa
Umbilical cord blood (UCB) has advantages over other tissues because it can be obtained without an invasive procedure and complex processing. We explored the availability of cryopreserved UCB cells as a source of mesenchymal stromal/stem cells (MSCs). MSCs were successfully isolated from six of 30 UCB units (median volume, 34.0 mL; median nucleated cell number, 4.4×10(8)) that were processed and cryopreserved using CP-1/human serum albumin. This isolation rate was lower than that (57%) from non-cryopreserved UCB cells...
April 18, 2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/28411967/utility-of-relative-adc-ratio-in-patient-selection-for-endovascular-revascularization-of-large-vessel-occlusion
#13
Narihide Shinoda, Shinya Hori, Kazuyuki Mikami, Toshiaki Bando, Daisuke Shimo, Takahiro Kuroyama, Yoji Kuramoto, Masato Matsumoto, Osamu Hirai, Yasushi Ueno
PURPOSE: The relative apparent diffusion coefficient (ADC) ratio on magnetic resonance imaging (MRI) can be used to evaluate the degree of ischemia. Here, we assessed the predictability of ischemic reversibility and the risk of hemorrhagic transformation using the relative ADC ratio. METHODS: This single-center retrospective study analyzed 56 patients with acute occlusion of the internal carotid artery (ICA) or the middle cerebral artery (M1) with endovascular revascularization...
April 12, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28410888/temperature-control-strategy-to-enhance-the-activity-of-yeast-inoculated-into-compost-raw-material-for-accelerated-composting
#14
Kiyohiko Nakasaki, Hidehira Hirai
The effects of inoculating the mesophilic yeast Pichia kudriavzevii RB1, which is able to degrade organic acids, on organic matter degradation in composting were elucidated. When model food waste with high carbohydrate content (C/N=22.3) was used, fluctuation in the inoculated yeast cell density was observed, as well as fluctuation in the composting temperature until day 5 when the temperature rose to 60°C, which is lethal for the yeast. After the decrease in yeast, acetic acid accumulated to levels as high as 20mg/g-ds in the composting material and vigorous organic matter degradation was inhibited...
April 11, 2017: Waste Management
https://www.readbyqxmd.com/read/28408728/high-signal-intensity-in-arterial-walls-on-diffusion-weighted-magnetic-resonance-imaging-in-the-active-phase-of-takayasu-arteritis
#15
Yasuyoshi Kuroiwa, Hiroshi Tai, Atsushi Yamashita, Eiji Furukoji, Yasushi Kihara, Toshinori Hirai, Yujiro Asada, Takuroh Imamura
No abstract text is available yet for this article.
April 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28406527/modified-weekly-regimen-of-cisplatin-epirubicin-and-paclitaxel-induced-a-durable-response-in-two-cases-of-metastatic-extramammary-paget-s-disease
#16
Ikuko Hirai, Takeru Funakoshi
Metastatic extramammary Paget's disease (EMPD) is a rare cancer with no standardized treatment. We report two cases of metastatic EMPD treated with a modified weekly PET (cisplatin, epirubicin and paclitaxel) regimen given biweekly (i.e. 2 weeks on/2 weeks off) that had durable responses. Case 1 was a 74-year-old man with EMPD metastatic to lymph nodes, lung, and bone who presented with a hemorrhagic tumor on the scrotum. We tried the PET regimen weekly, but adjusted the interval to biweekly after two doses because of hematological side-effects...
April 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28403114/prevalence-of-inappropriate-antibiotic-prescriptions-after-the-great-east-japan-earthquake-2011
#17
Kentaro Iwata, Takahiko Fukuchi, Midori Hirai, Kenichi Yoshimura, Yasuhiro Kanatani
Few studies have investigated the appropriateness of antibiotic use in postdisaster settings. We retrospectively evaluated clinical databases on health care delivered at clinics near shelters set up after the Great East Japan Earthquake, 2011. We defined appropriate, acceptable, and inappropriate antibiotic use for each diagnostic category, by applying and adopting precedent studies and clinical guidelines. From March to July, 2011, a total of 23,704 clinic visits occurred at 98 shelters with 7934 residents...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28399369/pyrolysis-of-helical-coordination-polymers-for-metal-sulfide-based-helices-with-broadband-chiroptical-activity
#18
Kenji Hirai, Bongjun Yeom, Kazuki Sada
Fabrication of chiroptical materials with broadband response in visible light region is vital to fully realize their potential applications. One way to achieve broadband chiroptical activity is to fabricate chiral nanostructures from materials that exhibit broadband absorption in the visible light region. However, the compounds used for chiroptical materials have predominantly been limited to the materials with narrowband spectral response. Here we synthesize Ag2S-based nanohelices derived from helical coordination polymers...
April 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28386107/constitutively-active-abl-family-kinases-tel-abl-and-tel-arg-harbor-distinct-leukemogenic-activities-in-vivo
#19
A Yokota, H Hirai, T Shoji, T Maekawa, K Okuda
ABL (ABL1) and ARG (ABL2) are highly homologous to each other in overall domain structure and amino acid sequence, with the exception of their C-termini. As with ABL, translocations that fuse ARG to ETV6/TEL have been identified in patients with leukemia. To assess the in vivo leukemogenic activity of constitutively active ABL and ARG, we generated a bone marrow (BM) transplantation model using the chimeric forms TEL/ABL and TEL/ARG, which have comparable kinase activities. TEL/ABL rapidly induced fatal myeloid leukemia in recipient mice, whereas recipients of TEL/ARG-transduced cells did not develop myeloid leukemia; instead, they succumbed to a long-latency infiltrative mastocytosis that could be adoptively transferred to secondary recipients...
April 7, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28385052/perinatal-ssri-exposure-permanently-alters-cerebral-serotonin-receptor-mrna-in-mice-but-does-not-impact-adult-behaviors
#20
Lauritz R Meyer, Benjamin Dexter, Cecilia Lo, Elizabeth Kenkel, Takahito Hirai, Robert D Roghair, Sarah E Haskell
PURPOSE: Associations have been made between maternal selective serotonin reuptake inhibitor (SSRI) use during pregnancy and altered behavior in offspring, including an increased risk of autism. Given the important role serotonin plays in behavior, we hypothesized SSRI exposure in the perinatal period would alter central serotonin receptor expression and program adult behaviors in mice. METHODS: Female mice were injected with sertraline or saline throughout pregnancy...
April 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
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