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https://www.readbyqxmd.com/read/28715458/evaluation-of-metagenetic-community-analysis-of-planktonic-copepods-using-illumina-miseq-comparisons-with-morphological-classification-and-metagenetic-analysis-using-roche-454
#1
Junya Hirai, Satoshi Nagai, Kiyotaka Hidaka
Metagenetics is a rapid and taxonomically comprehensive method for revealing community structures within environmental samples, based on large amounts of sequence data produced by high-throughput sequencers. Because community structures of planktonic copepods are important in the ocean owing to their high diversity and abundance, a metagenetic analysis of the 28S D2 region using Roche 454 was previously developed. However, the Illumina MiSeq platform with a high sequence output is being used more frequently in metagenetics, and non-calanoid copepods have not previously been fully evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28715379/detection-of-microrna-expression-in-peritoneal-membrane-of-rats-using-quantitative-real-time-pcr
#2
Keiji Hirai, Hiromichi Yoshizawa, Toshimi Imai, Yusuke Igarashi, Ichiro Hirahara, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita
MicroRNAs (miRNAs) are small noncoding RNAs that regulate messenger RNA expression post-transcriptionally. The miRNA expression profile has been investigated in various organs and tissues in rat. However, standard methods for the purification of miRNAs and detection of their expression in rat peritoneal membrane have not been well established. We have developed an effective and reliable method to purify and quantify miRNAs using quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) in rat peritoneal membrane...
June 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714681/-visible-5d-orbital-states-in-a-pleochroic-oxychloride
#3
Daigorou Hirai, Takeshi Yajima, Daisuke Nishio-Hamane, Changsu Kim, Hidefumi Akiyama, Mitsuaki Kawamura, Takahiro Misawa, Nobuyuki Abe, Taka-Hisa Arima, Zenji Hiroi
Transition metal compounds sometimes exhibit attractive colors. Here, we report a new oxychloride Ca3ReO5Cl2 that shows unusually distinct pleochroism; that is, the material exhibits different colors depending on the viewing direction. This pleochroism is a consequence of the coincidental complex crystal field splitting of the 5d orbitals of the Re6+ ion in a square-pyramidal coordination of low-symmetry in the energy range of the visible spectrum. Since the relevant d-d transitions show characteristic polarization dependence according to the optical selection rule, the orbital states are "visible" in Ca3ReO5Cl2...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28712297/photocatalytic-conversion-of-nitrogen-to-ammonia-with-water-on-surface-oxygen-vacancies-of-titanium-dioxide
#4
Hiroaki Hirakawa, Masaki Hashimoto, Yasuhiro Shiraishi, Takayuki Hirai
Ammonia (NH3) is an essential chemical in modern society. It is currently manufactured by the Haber-Bosch process using H2 and N2 under extremely high pressure (>200 bar) and high temperature (>673 K) conditions. Photocatalytic NH3 production from water and N2 at atmospheric pressure and room temperature is ideal. Several semiconductor photocatalysts have been proposed, but all suffer from low efficiency. Here we report that a commercially-available TiO2 with a large number of surface oxygen vacancies, when photoirradiated by UV light in pure water with N2, successfully produces NH3...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28711324/prognostic-impact-of-programmed-death-ligand-1-expression-in-correlation-with-human-leukocyte-antigen-class-i-expression-status-in-stage-i-adenocarcinoma-of-the-lung
#5
Ayako Hirai, Kazue Yoneda, Shohei Shimajiri, Koji Kuroda, Takeshi Hanagiri, Yoshihisa Fujino, Fumihiro Tanaka
OBJECTIVE: The study objective was to investigate the prognostic impact of programmed death-ligand 1 expression in correlation with human leukocyte antigen class I expression on tumor cells in early-stage adenocarcinoma of the lung, because both programmed death-ligand 1 and human leukocyte antigen class I molecules play important roles in cancer immunity. METHODS: Ninety-four patients with completely resected pathologic stage I lung adenocarcinoma were retrospectively reviewed...
June 12, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28710488/pathological-effect-of-arterial-ischaemia-and-venous-congestion-on-rat-testes
#6
Shuichi Hirai, Naoyuki Hatayama, Munekazu Naito, Kenta Nagahori, Shinichi Kawata, Shogo Hayashi, Ning Qu, Hayato Terayama, Sunao Shoji, Masahiro Itoh
Many studies on various organs have concluded that venous congestion (VC) causes severe organ dysfunction with elevation of oxidative stress relative to that of arterial ischaemia (AI). However, a comparison of the pathological effects of AI and VC on the testes has not been conducted. In this study, models of AI and VC and their reperfusion in rat testes, respectively, were developed and analysed. Testicular arteries or veins were interrupted for 6 h, re-perfused and kept for 4 weeks; the effects on the testes were then evaluated...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28703347/non-pigmenting-fixed-drug-eruption-with-mixed-features-of-acute-generalized-exanthematous-pustulosis-induced-by-pseudoephedrine-a-case-report
#7
Risa Fukuda, Takeshi Ouchi, Ikuko Hirai, Takeru Funakoshi, Aki Honda, Keiji Tanese, Akiko Tanikawa, Masayuki Amagai, Hayato Takahashi
No abstract text is available yet for this article.
August 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28702181/the-major-thoracic-vascular-invasion-of-lung-cancer
#8
Soichi Oka, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Yoshinobu Ichiki, Shohei Shimajiri, Takatoshi Aoki, Fumihiro Tanaka
BACKGROUND: We actually investigated the surgical and pathological findings in cases which tumor invasion of the major thoracic vessels was suspected based on the preoperative Computed tomography (CT) findings. MATERIALS AND METHODS: We retrospectively reviewed our prospective database of all patients, who underwent lung resection for lung cancer from 2012 to 2014. 387 patients underwent lung cancer surgery. Among these patients, we analyzed 30 patients in whom pulmonary artery (PA) invasion was suspected and 11 patients in whom pulmonary vein (PV) or left atrium (LA) invasion was suspected based on the preoperative CT findings...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28697135/validation-of-the-2012-fukuoka-consensus-guideline-for-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-from-a-single-institution-experience
#9
Songfeng Yu, Naoki Takasu, Toshihiro Watanabe, Tsuyoshi Fukumoto, Shinji Okazaki, Koji Tezuka, Shuichiro Sugawara, Ichiro Hirai, Wataru Kimura
OBJECTIVES: The 2012 Fukuoka consensus guideline has stratified the risks of malignant intraductal papillary mucinous neoplasm (IPMN) of the pancreas into "high-risk stigmata" (HRS) and "worrisome feature" (WF). This study aimed to evaluate its clinical validity based on a single institution experience. METHODS: Eighty-nine patients who underwent surgical resection with pathological diagnosis of IPMN were retrospectively studied. RESULTS: High-risk stigmata was significantly correlated with the prevalence of malignant IPMN as compared with WF...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28693169/evaluation-of-erlotinib-for-the-treatment-of-patients-with-non-small-cell-lung-cancer-with-epidermal-growth-factor-receptor-wild-type
#10
Fumihiko Hirai, Makoto Edagawa, Shinichiro Shimamatsu, Ryo Toyozawa, Gouji Toyokawa, Kaname Nosaki, Masafumi Yamaguchi, Takashi Seto, Mitsuhiro Takenoyama, Yukito Ichinose
Erlotinib is one of the treatment choices for patients with advanced non-small cell lung cancer (NSCLC), regardless of the epidermal growth factor receptor (EGFR) mutation status. However, its efficacy for the treatment of patients with NSCLC with EGFR wild type or who are beyond the usage of gefitinib remains controversial. The present study therefore retrospectively assessed the efficacy of erlotinib in patients with wild type EGFR who had previously undergone gefitinib therapy. A total of 222 patients with NSCLC who received chemotherapeutic treatment with erlotinib between July 2007 and February 2013 were evaluated...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28689880/characterization-of-crf1-receptor-antagonists-with-differential-peripheral-vs-central-actions-in-crf-challenge-in-rats
#11
Maiko Tanaka, Yoshiro Tomimatsu, Katsuya Sakimura, Yoshikazu Ootani, Yuu Sako, Takuto Kojima, Kazuyoshi Aso, Takahiko Yano, Keisuke Hirai
The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxiety behavior were measured after CRF challenge intravenously (i.v.) for the peripheral administration or intracerebroventricularly (i.c.v.) for the central administration. Plasma ACTH concentration was significantly increased by both administration routes of CRF; however, hyperlocomotion and anxiety behavior were induced only by the i...
July 6, 2017: Peptides
https://www.readbyqxmd.com/read/28682648/kinase-inhibitors-of-the-igf-1r-as-a-potential-therapeutic-agent-for-rheumatoid-arthritis
#12
Hiroshi Tsushima, Shinji Morimoto, Maki Fujishiro, Yuko Yoshida, Kunihiro Hayakawa, Takuya Hirai, Tomoko Miyashita, Keigo Ikeda, Ken Yamaji, Kenji Takamori, Yoshinari Takasaki, Iwao Sekigawa, Naoto Tamura
We have previously shown that the inhibition of connective tissue growth factor (CTGF) is a potential therapeutic strategy against rheumatoid arthritis (RA). CTGF consists of four distinct modules, including the insulin-like growth factor binding protein (IGFBP). In serum, insulin-like growth factors (IGFs) bind IGFBPs, interact with the IGF-1 receptor (IGF-1 R), and regulate anabolic effects and bone metabolism. We investigated the correlation between IGF-1 and the pathogenesis of RA, and the inhibitory effect on osteoclastogenesis and angiogenesis of the small molecular weight kinase inhibitor of the IGF-1 R, NVP-AEW541, against pathogenesis of RA in vitro...
July 6, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28681967/augmentation-of-fracture-healing-by-hydroxyapatite-collagen-paste-and-bone-morphogenetic-protein-2-evaluated-using-a-rat-femur-osteotomy-model
#13
Xuetao Wei, Satoru Egawa, Renpei Matsumoto, Hiroaki Yasuda, Keigo Hirai, Toshitaka Yoshii, Atsushi Okawa, Takehiko Nakajima, Shinichi Sotome
In fracture treatment, biological bone union generally depends on the bone's natural fracture healing capacity, even in surgically treated cases. Hydroxyapatite/collagen composite (HAp/Col) has high osteoconductivity and stimulates osteogenic progenitors. Furthermore, it has the potent capacity to adsorb bone morphogenetic proteins (BMPs). In this study, we prepared an injectable HAp/Col paste and evaluated its augmentation of bone union. Furthermore, the effect of HAp/Col paste combined with BMP-2 was also evaluated...
July 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28680823/efficacy-and-safety-of-adding-mizoribine-to-standard-treatment-in-patients-with-immunoglobulin-a-nephropathy-a-randomized-controlled-trial
#14
Keiji Hirai, Susumu Ookawara, Taisuke Kitano, Haruhisa Miyazawa, Kiyonori Ito, Yuichirou Ueda, Yoshio Kaku, Taro Hoshino, Honami Mori, Izumi Yoshida, Kenji Kubota, Yasuyoshi Yamaji, Tetsuro Takeda, Yoshikazu Nakamura, Kaoru Tabei, Yoshiyuki Morishita
BACKGROUND: Mizoribine (MZR) is an immunosuppressive drug used in Japan for treating patients with lupus nephritis and nephrotic syndrome and has been also reportedly effective in patients with immunoglobulin A (IgA) nephropathy. However, to date, few randomized control studies of MZR are performed in patients with IgA nephropathy. Therefore, this prospective, open-label, randomized, controlled trial aimed to investigate the efficacy and safety of adding MZR to standard treatment in these patients, and was conducted between April 1, 2009, and March 31, 2016, as a multicenter study...
June 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28678510/water-proton-relaxivities-of-radical-nanoparticles-self-assembled-via-hydration-or-dehydration-processes
#15
Kosuke Morishita, Yuna Okamoto, Shuhei Murayama, Kazuteru Usui, Eriko Ohashi, Go Hirai, Ichio Aoki, Satoru Karasawa
Nanoparticles capable of accumulating in tumor tissues are promising materials for tumor imaging and therapy. In this study, two radical nanoparticles (RNPs)-denoted as 1 and 2-composed of self-assembled ureabenzene derivatives possessing one or two amphiphilic side chains were demonstrated as candidates for metal-free functional magnetic resonance imaging (MRI) contrast agents (CAs). Due to the self-assembly behavior of 1 and 2 in a saline solution, spherical RNPs of sizes ~50-90 and ~30-100 nm were detected...
July 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28677528/generation-of-induced-pluripotent-stem-cells-from-chinese-hamster-embryonic-fibroblasts
#16
Haiyun Pei, Hsu-Yuan Fu, Hiroyuki Hirai, Dong Seong Cho, Timothy D O'Brien, James Dutton, Catherine M Verfaillie, Wei-Shou Hu
We derived a stable cell line from Chinese hamster embryonic fibroblasts by transduction of four mouse transcription factors (M3O, Sox2, Klf4, and n-Myc) using a lentiviral vector. The cell line possess all the characteristics of an induced pluripotent stem cell (iPSC) line. Given that Chinese hamster ovary (CHO) cells are the predominant host cells used for therapeutic protein production and no pluripotent stem cell line or other normal cell line has been isolated from Chinese hamster, this iPSC line may serve as a useful tool for research using CHO cells or even be used for deriving new cell lines...
May 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28675666/characterization-of-poly-l-glutamic-acid-grafted-hyaluronan-as-a-novel-candidate-medicine-and-biomedical-device-for-intra-articular-injection
#17
Kazuaki Muramatsu, Yuya Tajima, Rin Kaneko, Yuuta Yanagita, Hiroyuki Hirai, Nana Hiura
A novel hyaluronan (HA) derivative, poly(L-glutamic acid)-grafted hyaluronan (PGA-g-HA), was synthesized to improve the durability of conventional HA products for intra-articular injection. The purpose of this study was to investigate the characteristics of the novel HA derivative in terms of viscoelasticity, degradation behavior, non-immunogenicity, and bioactivity using preliminary in vitro and in vivo experiments. The storage modulus (G') and loss modulus (G'') of PGA-g-HA were similar to those of HA80 (approximately 8...
July 4, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28670237/long-term-safety-and-efficacy-of-adalimumab-for-intestinal-beh%C3%A3-et-s-disease-in-the-open-label-study-following-a-phase-3-clinical-trial
#18
Nagamu Inoue, Kiyonori Kobayashi, Makoto Naganuma, Fumihito Hirai, Morio Ozawa, Dilek Arikan, Bidan Huang, Anne M Robinson, Roopal B Thakkar, Toshifumi Hibi
BACKGROUND/AIMS: Intestinal Behçet's disease (BD) is an immune-mediated inflammatory disorder. We followed up the patients and evaluated safety profile and effectiveness of adalimumab for the treatment of intestinal BD through 100 weeks rolled over from the 52 week clinical trial (NCT01243671). METHODS: Patients initiated adalimumab therapy at 160 mg at week 0, followed by 80 mg at week 2, followed by 40 mg every other week until the end of the study. Long-term safety and all adverse events (AEs) were examined...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28667792/phase-i-study-of-salazosulfapyridine-in-combination-with-cisplatin-and-pemetrexed-for-advanced-non-small-cell-lung-cancer
#19
Kohei Otsubo, Kaname Nosaki, Chiyo K Imamura, Hiroaki Ogata, Akitaka Fujita, Shinya Sakata, Fumihiko Hirai, Gouji Toyokawa, Eiji Iwama, Taishi Harada, Takashi Seto, Mitsuhiro Takenoyama, Takeshi Ozeki, Taisei Mushiroda, Mieko Inada, Junji Kishimoto, Kenji Tsuchihashi, Kentaro Suina, Osamu Nagano, Hideyuki Saya, Yoichi Nakanishi, Isamu Okamoto
Splice variant isoforms of CD44 (CD44v) are a marker of cancer stem cells (CSCs) in solid tumors. They stabilize the xCT subunit of the transporter system xc(-) and thereby promote synthesis of the antioxidant glutathione. Salazosulfapyridine (SASP) is an inhibitor of xCT and suppresses the proliferation of CD44v-positive cancer cells. Chemotherapy-naïve patients with advanced nonsquamous non-small cell lung cancer were enrolled in a dose-escalation study (standard 3 + 3 design) of SASP in combination with cisplatin and pemetrexed...
July 1, 2017: Cancer Science
https://www.readbyqxmd.com/read/28663108/expression-patterns-of-sex-differentiation-related-genes-during-gonadal-sex-change-in-the-protogynous-wrasse-halichoeres-trimaculatus
#20
Ryo Horiguchi, Ryo Nozu, Toshiaki Hirai, Yasuhisa Kobayashi, Masaru Nakamura
The three-spot wrasse, Halichoeres trimaculatus, can change sex from female to male (i.e. protogyny) due to sharp decrease in endogenous estrogen. During the sex change, ovarian tissue degenerates and testicular tissue arises newly. Finally, ovarian tissue disappears completely and replaces into mature testis. In order to predict the molecular mechanisms controlling the processes of sex change, we investigated the expression patterns of four genes (rspo1, figla, sox9b and amh), which have been thought to be associated with ovarian/testicular differentiation in vertebrates...
June 26, 2017: General and Comparative Endocrinology
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