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https://www.readbyqxmd.com/read/28213683/phase-ii-study-of-bevacizumab-and-irinotecan-as-second-line-therapy-for-patients-with-metastatic-colorectal-cancer-previously-treated-with-fluoropyrimidines-oxaliplatin-and-bevacizumab
#1
Hidekazu Kuramochi, Masayuki Ando, Michio Itabashi, Go Nakajima, Kazuyuki Kawakami, Mie Hamano, Eiichi Hirai, Hajime Yokomizo, Ryuji Okuyama, Tatsuo Araida, Kazuhiko Yoshimatsu, Shingo Kameoka, Kazuhiko Hayashi
PURPOSE: Fluorouracil and folinic acid with irinotecan (FOLFIRI) plus bevacizumab (BV) is widely used as second-line chemotherapy for patients with metastatic colorectal cancer (mCRC) previously treated with fluoropyrimidines, oxaliplatin, and BV. FOLFIRI requires a CV catheter and an infusion pump, which are inconvenient for patients. Sufficient data are not available for characterizing the effectiveness of fluoropyrimidines beyond first disease progression. In this study, we evaluated the efficacy and safety of irinotecan (CPT-11) plus BV as second-line therapy...
February 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28209592/comparison-of-diagnostic-performance-of-two-question-screen-and-15-depression-screening-instruments-for-older-adults-systematic-review-and-meta-analysis
#2
REVIEW
Kelvin K F Tsoi, Joyce Y C Chan, Hoyee W Hirai, Samuel Y S Wong
BackgroundScreening for depression in older adults is recommended.AimsTo evaluate the diagnostic accuracy of the Two-Question Screen for older adults and compare it with other screening instruments for depression.MethodWe undertook a literature search for studies assessing the diagnostic performance of depression screening instruments in older adults. Combined diagnostic accuracy including sensitivity and specificity were the primary outcomes. Potential risks of bias and the quality of studies were also assessed...
February 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28209294/sulfated-glycosaminoglycans-and-non-classically-secreted-proteins-basic-fgf-and-epimorphin-coordinately-regulate-tgf-%C3%AE-induced-cell-behaviors-of-human-scar-dermal-fibroblasts
#3
Tomoatsu Horigome, Shinya Takumi, Kota Shirai, Takumi Kido, Natsumi Hagiwara-Chatani, Ayumi Nakashima, Naoki Adachi, Hiroko Yano, Yohei Hirai
BACKGROUND: Upon skin injuries, dermal fibroblasts actively produce transforming growth factor-β (TGF-β), which leads to the formation of α-smooth muscle actin (αSMA)-positive granulation tissues. The hyperplasia or incomplete regression of these tissues subsequently causes scar formation in the skin, where sulfated glycosaminoglycans (GAGs), side chains of unique proteoglycans, are supposed to play important roles. OBJECTIVE: The aim of this study is to clarify the effects of sulfated GAGs on dermal cell behaviors triggered by the TGF-β signaling, along with its possible regulators basic fibroblast growth factor (bFGF) and cell surface epimorphin...
February 3, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28197720/single-nucleotide-polymorphisms-in-the-whole-genome-sequence-data-of-shiga-toxin-producing-escherichia-coli-o157-h7-h-strains-by-cultivation
#4
Eiji Yokoyama, Shinichiro Hirai, Taichiro Ishige, Satoshi Murakami
Nine Shiga toxin-producing Escherichia coli O157:H7/H- (O157) strains were serially cultured three times on LB agar plates. After each sub-culture, five colonies were picked for DNA isolation and whole genome sequence (WGS) analysis. After exclusion of possible recombination-related SNPs, 11, 9, and 34 single-nucleotide polymorphisms (SNPs) were detected in genes in the backbone, O-island, and mobile elements gene categories. This suggested that those SNPs due to cultivation could influence the threshold value set for molecular epidemiological studies of O157...
February 14, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28185202/erratum-to-bortezomib-interferes-with-adhesion-of-b-cell-precursor-acute-lymphoblastic-leukemia-cells-through-sparc-up-regulation-in-human-bone-marrow-mesenchymal-stromal-stem-cells
#5
Masaki Iwasa, Yasuo Miura, Aya Fujishiro, Sumie Fujii, Noriko Sugino, Satoshi Yoshioka, Asumi Yokota, Terutoshi Hishita, Hideyo Hirai, Akira Andoh, Tatsuo Ichinohe, Taira Maekawa
No abstract text is available yet for this article.
February 9, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28181553/corrigendum-suppression-of-b-function-strongly-supports-the-modified-abce-model-in-tricyrtis-sp-liliaceae
#6
Masahiro Otani, Ahmad Sharifi, Shosei Kubota, Kanako Oizumi, Fumi Uetake, Masayo Hirai, Yoichiro Hoshino, Akira Kanno, Masaru Nakano
No abstract text is available yet for this article.
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28175016/p215-clinical-features-of-chronic-enteropathy-associated-with-slco2a1-gene-ceas
#7
J Umeno, M Esaki, A Hirano, T Hisamatsu, K Watanabe, F Hirai, T Matsui, T Hibi, T Kitazono, T Matsumoto
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174763/tailor-made-synthesis-of-fully-alkylated-arylated-nicotinates-by-fecl3-mediated-condensation-of-enamino-esters-with-enones
#8
Sho Hirai, Yurie Horikawa, Haruyasu Asahara, Nagatoshi Nishiwaki
A new method for synthesizing polyalkylated/arylated nicotinates is established using a condensation of enamino esters with enones in the presence of FeCl3. This method facilitates the introduction of alkyl or aryl groups at any position on demand, which has not been achieved by other procedures.
February 8, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28174404/-two-cases-of-invasive-thymoma-with-taste-disorder
#9
Tatsuya Katayama, Shinji Hirai
Two 50s female patients with the taste disorder of sweet taste loss and stage IV a type B2 invasive thymoma underwent surgery at our hospital. One patient with myasthenia gravis (MG) developed postoperative myasthenic crisis and recovered by the treatment with plasma apheresis and steroid pulse therapy. Her taste disorder fully recovered together with her MG symptom. The taste disorder of the other patient without MG had persisted for 3 years after the surgery. The taste disorder of sweet taste loss was reported as one of non-motor symptoms caused by MG-related autoimmune mechanisms associated with thymoma, improving with the therapy for MG...
February 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28164864/towards-a-unified-model-of-neutrino-nucleus-reactions-for-neutrino-oscillation-experiments
#10
Satoshi Nakamura, Hiroyuki Kamano, Yoshinari Hayato, Masanori Hirai, Wataru Horiuchi, Shunzo Kumano, Tomoya Murata, Koichi Saito, Makoto Sakuda, Toru Sato, Yasuyuki Suzuki
A precise description of neutrino-nucleus reactions will play a key role in addressing fundamental questions such as the leptonic CP violation and the neutrino mass hierarchy through analyzing data from next-generation neutrino oscillation experiments. The neutrino energy relevant to the neutrino-nucleus reactions spans a broad range and, accordingly, the dominant reaction mechanism varies across the energy region from quasi-elastic scattering through nucleon resonance excitations to deep inelastic scattering...
February 6, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28156249/utility-of-mri-based-disproportionately-enlarged-subarachnoid-space-hydrocephalus-scoring-for-predicting-prognosis-after-surgery-for-idiopathic-normal-pressure-hydrocephalus-clinical-research
#11
Narihide Shinoda, Osamu Hirai, Shinya Hori, Kazuyuki Mikami, Toshiaki Bando, Daisuke Shimo, Takahiro Kuroyama, Yoji Kuramoto, Masato Matsumoto, Yasushi Ueno
OBJECTIVE The presence of disproportionately enlarged subarachnoid space hydrocephalus (DESH) on brain imaging is a recognized finding of idiopathic normal pressure hydrocephalus (iNPH), but the features of DESH can vary across patients. The aim of this study was to evaluate the utility of MRI-based DESH scoring for predicting prognosis after surgery. METHODS In this single-center, retrospective cohort study, the DESH score was determined by consensus between a group of neurosurgeons, neurologists, and a neuroradiologist based on the preoperative MRI findings of the patients with suspected iNPH...
February 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28156246/present-epidemiology-of-chronic-subdural-hematoma-in-japan-analysis-of-63-358-cases-recorded-in-a-national-administrative-database
#12
Hiroyuki Toi, Keita Kinoshita, Satoshi Hirai, Hiroki Takai, Keijiro Hara, Nobuhisa Matsushita, Shunji Matsubara, Makoto Otani, Keiji Muramatsu, Shinya Matsuda, Kiyohide Fushimi, Masaaki Uno
OBJECTIVE Aging of the population may lead to epidemiological changes with respect to chronic subdural hematoma (CSDH). The objectives of this study were to elucidate the current epidemiology and changing trends of CSDH in Japan. The authors analyzed patient information based on reports using a Japanese administrative database associated with the diagnosis procedure combination (DPC) system. METHODS This study included patients with newly diagnosed CSDH who were treated in hospitals participating in the DPC system...
February 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28154260/identification-of-adenovirus-derived-cell-penetrating-peptide
#13
Takamasa Hirai, Yoshiaki Yamagishi, Naoya Koizumi, Miwa Nonaka, Rina Mochida, Kenta Shida, Tetsuya Nomura, Makiko Fujii, Fuminori Sakurai, Hiroyuki Mizuguchi, Yoshiteru Watanabe, Naoki Utoguchi
Cell-penetrating peptides (CPPs) have been highly anticipated as an efficient delivery system due to their ability to cross biological membranes and transport various cargoes into cells. In the present study, we have identified adenovirus-derived CPPs using various capsid-mutant adenovirus (Ad) vectors. First, we examined the endocytosis-inducing ability of these vectors. A fiber-shaft substituted Ad vector, Ad type 5 vector with the fiber shaft domain replaced by that derived from Ad type 35, induced the highest fluorescein isothiocyanate (FITC)-dextran uptake into a human liver cell line, HepG2 cells...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28149639/flap-choice-for-closure-of-open-window-thoracotomy-a-response-to-the-author-of-the-article-entitled-the-omentum-flap-for-empyema-treatment-indications-and-disadvantages
#14
Shuichi Shinohara, Yasuhiro Chikaishi, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Fumihiro Tanaka
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28148694/myalgia-in-patients-with-dermatomyositis-and-polymyositis-is-attributable-to-fasciitis-rather-than-myositis-a-retrospective-study-of-32-patients-who-underwent-histopathological-examinations
#15
Kentaro Noda, Ken Yoshida, Taro Ukichi, Kazuhiro Furuya, Kenichiro Hirai, Isamu Kingetsu, Daitaro Kurosaka
OBJECTIVE: To determine the association between fasciitis and the clinical variables in patients with dermatomyositis (DM) and polymyositis (PM). METHODS: We retrospectively reviewed the medical records of 32 patients (24 DM, 8 PM) with newly diagnosed DM and PM and in whom fascia and muscle specimens were histopathologically examined. The relationship between fasciitis and the clinical variables was statistically analyzed. These included age, sex, myalgia, muscle weakness, creatine kinase (CK) and aldolase activities, anti-Jo1 antibody, interstitial lung disease, and malignancy...
February 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28142187/spatial-regulation-of-the-kh-domain-rna-binding-protein-rnc1-mediated-by-a-crm1-independent-nuclear-export-system-in-schizosaccharomyces-pombe
#16
Ryosuke Satoh, Yasuhiro Matsumura, Akitomo Tanaka, Makoto Takada, Yuna Ito, Kanako Hagihara, Masahiro Inari, Ayako Kita, Akira Fukao, Toshinobu Fujiwara, Shinya Hirai, Tokio Tani, Reiko Sugiura
RNA-binding proteins (RBPs) play important roles in the posttranscriptional regulation of gene expression, including mRNA stability, transport, and translation. Fission yeast rnc1(+) encodes a K Homology (KH)-type RBP, which binds and stabilizes the Pmp1 MAPK phosphatase mRNA thereby suppressing the Cl(-) hypersensitivity of calcineurin deletion and MAPK signaling mutants. Here, we analyzed the spatial regulation of Rnc1 and discovered a putative nuclear export signal (NES)Rnc1 , which dictates the cytoplasmic localization of Rnc1 in a Crm1-independent manner...
January 31, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28131171/clinically-mild-infantile-encephalopathy-associated-with-excitotoxicity
#17
Nozomi Hirai, Daisuke Yoshimaru, Yoko Moriyama, Takafumi Honda, Kumi Yasukawa, Jun-Ichi Takanashi
Acute infectious encephalopathy is very frequently observed in children in East Asia including Japan. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype in Japan; however, more than 40% of the patients remain unclassified into specific syndromes. To investigate the underlying pathomechanism in those with unclassified acute encephalopathy, we evaluated brain metabolism by MR spectroscopy. Among 20 patients with acute encephalopathy admitted to our hospital during January 2015 to May 2016, 12 could not be classified into specific syndromes...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28127757/donor-bone-marrow-cells-are-essential-for-inkt-cell-mediated-foxp3-treg-cell-expansion-in-a-murine-model-of-transplantation-tolerance
#18
Satoshi Miyairi, Toshihito Hirai, Rumi Ishii, Masayoshi Okumi, Shinichi Nunoda, Kenji Yamazaki, Yasuyuki Ishii, Kazunari Tanabe
Mixed chimerism induction is the most reliable method for establishing transplantation tolerance. We previously described a novel treatment using a suboptimal dose of anti-CD40 ligand (anti-CD40L) and liposomal formulation of a ligand for invariant natural killer T cells administered to sub-lethally irradiated recipient mice after donor bone marrow cell (BMC) transfer. Recipient mice treated with this regimen showed expansion of a Foxp3-positive regulatory T(Treg) cell phenotype, and formation of mixed chimera...
January 26, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28124830/safety-and-feasibility-of-laparoscopic-multivisceral-resection-for-surgical-t4b-colon-cancers-retrospective-analyses
#19
Ryo Takahashi, Suguru Hasegawa, Kenjiro Hirai, Shigeo Hisamori, Koya Hida, Kenji Kawada, Yoshiharu Sakai
INTRODUCTION: Laparoscopic (Lap) surgery has not been established as a standard procedure for locally advanced colon cancers. Here, we evaluated the safety and feasibility of Lap multivisceral resection (MVR) for tumors that had invaded adjacent organs (T4b). METHODS: We performed retrospective analyses using a single institutional database. Eighty-four patients who underwent Lap or open MVR for surgical T4b primary colon cancers satisfied the inclusion criteria...
January 26, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28119150/vascular-katp-channels-mitigate-severe-muscle-o2-delivery-utilization-mismatch-during-contractions-in-chronic-heart-failure-rats
#20
Clark T Holdsworth, Scott K Ferguson, Trenton D Colburn, Alexander J Fees, Jesse C Craig, Daniel M Hirai, David C Poole, Timothy I Musch
The vascular ATP-sensitive K(+) (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to reach the PO2mv steady-state during contractions of the spinotrapezius muscle. Moreover, we hypothesized that subsequent KATP channel activation would oppose the effects of this inhibition. Muscle PO2mv (phosphorescence quenching) was measured during 180s of 1-Hz twitch contractions (∼6V) under control, glibenclamide (GLI, KATP channel antagonist; 5mg/kg) and pinacidil (PIN, KATP channel agonist; 5mg/kg) conditions in 16 male Sprague-Dawley rats with CHF induced via myocardial infarction (coronary artery ligation, left ventricular end-diastolic pressure: 18±1mmHg)...
January 22, 2017: Respiratory Physiology & Neurobiology
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