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https://www.readbyqxmd.com/read/29239062/gvhd-amelioration-by-human-bone-marrow-mesenchymal-stromal-stem-cell-derived-extracellular-vesicles-is-associated-with-peripheral-preservation-of-naive-t-cell-populations
#1
Sumie Fujii, Yasuo Miura, Aya Fujishiro, Takero Shindo, Yutaka Shimazu, Hideyo Hirai, Hidetoshi Tahara, Akifumi Takaori-Kondo, Tatsuo Ichinohe, Taira Maekawa
A substantial proportion of patients with acute graft-versus-host disease (aGVHD) respond to cell therapy with culture-expanded human bone marrow mesenchymal stromal/stem cells (BM-MSCs). However, the mechanisms by which these cells can ameliorate aGVHD-associated complications remain to be clarified. We show here that BM-MSC-derived extracellular vesicles (EVs) recapitulated the therapeutic effects of BM-MSCs against aGVHD. Systemic infusion of human BM-MSC-derived EVs prolonged the survival of mice with aGVHD and reduced the pathologic damage in multiple GVHD-targeted organs...
December 14, 2017: Stem Cells
https://www.readbyqxmd.com/read/29237151/repeated-combined-chemotherapy-with-cisplatin-lowers-carnitine-levels-in-gastric-cancer-patients
#2
Akimasa Kawai, Hideo Matsumoto, Youko Endou, Yui Honda, Hisako Kubota, Masaharu Higashida, Toshihiro Hirai
BACKGROUND/AIMS: Carnitine plays an important role in the metabolism of fatty acids. It has also been reported that the administration of anticancer drugs may lead to reductions in serum carnitine levels due to decreased activity of organic cation transporter novel 2, which plays a role in the reabsorption of carnitine in the tubules of the kidney. We therefore studied the change in carnitine levels when chemotherapy was administered repeatedly to patients with gastric cancer. METHODS: Ten patients with upper gastrointestinal cancer were enrolled in this study between December 2014 and August 2015...
December 13, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29235343/n-glucosides-of-fairy-chemicals-2-azahypoxanthine-and-2-aza-8-oxohypoxanthine-in-rice
#3
Jae-Hoon Choi, Jing Wu, Azusa Sawada, Syougo Takeda, Hirohide Takemura, Kaoru Yogosawa, Hirofumi Hirai, Mitsuru Kondo, Kunihisa Sugimoto, Tomohiro Asakawa, Makoto Inai, Toshiyuki Kan, Hirokazu Kawagishi
Plant growth stimulators, 2-azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), were isolated from the fairy-ring-forming fungus, Lepista sordida, and AHX-treated rice, respectively. Further metabolites of AHX were detected in AHX-treated rice by HPLC, and the metabolites 1-4 were isolated from the rice. The structures of 1-4 were determined by spectroscopic analysis and synthesis. Compounds 1-4 exhibited no significant activity against rice, indicating that rice regulates the activity of AHX and AOH by converting them into their glucosides...
December 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/29233150/a-prospective-study-of-magnetic-resonance-imaging-and-ultrasonography-mri-us-fusion-targeted-biopsy-and-concurrent-systematic-transperineal-biopsy-with-the-average-of-18-cores-to-detect-clinically-significant-prostate-cancer
#4
Yuji Hakozaki, Hisashi Matsushima, Jimpei Kumagai, Taro Murata, Tomoko Masuda, Yoko Hirai, Mai Oda, Nobuo Kawauchi, Munehiro Yokoyama, Yukio Homma
BACKGROUND: This study compared the detection rates for clinically significant prostate cancer (CSPC) between magnetic resonance imaging and ultrasonography (MRI/US)-fusion-targeted biopsy (TB), systematic biopsy (SB) and combination of TB and SB. METHODS: This prospective study evaluated simultaneous TB and SB for consecutive patients with suspicious lesions that were detected using pre-biopsy multiparametric MRI. A commercially available real-time virtual sonography system was used to perform the MRI/US-fusion TB with the transperineal technique...
December 12, 2017: BMC Urology
https://www.readbyqxmd.com/read/29232242/prediction-of-posthepatectomy-liver-failure-proposed-by-the-international-study-group-of-liver-surgery-residual-liver-function-estimation-with-99mtc-galactosyl-human-serum-albumin-scintigraphy
#5
Yoichi Mizutani, Toshinori Hirai, Shigeki Nagamachi, Atsushi Nanashima, Koichi Yano, Kazuhiro Kondo, Masahide Hiyoshi, Naoya Imamura, Tamasa Terada
PURPOSE: The International Study Group of Liver Surgery (ISGLS) proposed a definition and grading system for posthepatectomy liver failure (PHLF). We evaluated the usefulness of residual liver function estimation using Tc-galactosyl human serum albumin (Tc-GSA) for the prediction of PHLF. METHODS: Patients with liver tumors (n = 136) and scheduled for hepatectomy underwent Tc-GSA scintigraphy. Based on their imaging data, the maximal GSA removal rate (GSA-Rmax)was calculated using multicompartment analysis...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29221042/image-processing-pipeline-for-segmentation-and-material-classification-based-on-multispectral-high-dynamic-range-polarimetric-images
#6
Miguel Ángel Martínez-Domingo, Eva M Valero, Javier Hernández-Andrés, Shoji Tominaga, Takahiko Horiuchi, Keita Hirai
We propose a method for the capture of high dynamic range (HDR), multispectral (MS), polarimetric (Pol) images of indoor scenes using a liquid crystal tunable filter (LCTF). We have included the adaptive exposure estimation (AEE) method to fully automatize the capturing process. We also propose a pre-processing method which can be applied for the registration of HDR images after they are already built as the result of combining different low dynamic range (LDR) images. This method is applied to ensure a correct alignment of the different polarization HDR images for each spectral band...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220357/difference-of-the-progression-of-pulmonary-cysts-assessed-by-computed-tomography-among-copd-lymphangioleiomyomatosis-and-birt-hogg-dub%C3%A3-syndrome
#7
Kazunori Tobino, Toyohiro Hirai, Takeshi Johkoh, Kiminori Fujimoto, Atsushi Kawaguchi, Noriyuki Tomiyama, Kazuhisa Takahashi, Kuniaki Seyama
Many groups developed the methods to quantitatively analyze low attenuation area (LAA) on chest CT in patients with cystic lung diseases. Especially in COPD, it was reported that the cumulative size distribution of LAA clusters follows a power law characterized by the exponent D, which reflect the fractal dimension of terminal airspace geometry. We hypoyhesized that the quantitative charateristics of LAA clusters including fractal property might indicate the different features of the progression of cysts in cystic lung diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29213231/the-roles-of-cortical-slow-waves-in-synaptic-plasticity-and-memory-consolidation
#8
Daisuke Miyamoto, Daichi Hirai, Masanori Murayama
Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5-4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29211833/a-prospective-phase-ii-study-of-combined-androgen-blockade-in-patients-with-androgen-receptor-positive-metastatic-or-locally-advanced-unresectable-salivary-gland-carcinoma
#9
C Fushimi, Y Tada, H Takahashi, T Nagao, H Ojiri, T Masubuchi, T Matsuki, K Miura, D Kawakita, H Hirai, E Hoshino, S Kamata, T Saotome
Background: There is no standard first-line chemotherapy for recurrent/metastatic or unresectable locally advanced salivary gland carcinoma (SGC). Patients and methods: We conducted a single institution, open-label, single arm, phase II trial of combined androgen blockade (CAB) for androgen receptor (AR)-positive SGC. Leuprorelin acetate was administered subcutaneously at a dose of 3.75 mg every 4 weeks. Bicalutamide was administered orally at a daily dose of 80 mg...
December 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29210021/design-and-operation-of-the-transformed-national-healthy-start-evaluation
#10
Jamelle E Banks, Maura Dwyer, Ashley Hirai, Reem M Ghandour, Hani K Atrash
Purpose Improving pregnancy outcomes for women and children is one of the nation's top priorities. The Healthy Start (HS) program was created to address factors that contribute to high infant mortality rates (IMRs) and persistent disparities in IMRs. The program began in 1991 and was transformed in 2014 to apply lessons from emerging research, past evaluation findings, and expert recommendations. To understand the implementation and impact of the transformed program, there is a need for a robust and comprehensive evaluation...
December 5, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29199247/utility-of-indocyanine-green-video-angiography-for-sylvian-fissure-dissection-in-subarachnoid-hemorrhage-patients-sylvian-icg-technique
#11
Hiroyuki Toi, Nobuhisa Matsushita, Yukari Ogawa, Keita Kinoshita, Kohei Satoh, Hiroki Takai, Satoshi Hirai, Keijiro Hara, Shunji Matsubara, Masaaki Uno
Indocyanine green (ICG) emits fluorescence in the far-red domain under light excitation. ICG video angiography (ICG-VA) has been established as a useful method to evaluate blood flow in the operative field. We report the usefulness of ICG-VA for Sylvian fissure dissection in patients with subarachnoid hemorrhage (SAH). Subjects comprised 7 patients who underwent ICG-VA before opening the Sylvian fissure during neck clipping for ruptured cerebral aneurysm. We observed contrasted Sylvian veins before opening the Sylvian fissure using surgical microscopes...
December 1, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29196584/family-support-during-resuscitation-a-quality-improvement-initiative
#12
Rache Marie Mureau-Haines, Mandy Boes-Rossi, Susan Christine Casperson, Basak Çoruh, Amy M Furth, Amy Haverland, Farah Herrera, Tracy Hirai-Seaton, Carol Kummet, Hkori Ngo, Stephanie Shushan, Patricia A Kritek, Sheryl A Greco
BACKGROUND: Despite increasing support for family presence during cardiopulmonary resuscitation, a review of the literature revealed no published protocols or training curricula to guide hospitals in implementing a family support provider role. OBJECTIVES: To develop a curriculum and train dedicated resuscitation team members whose role is to provide family support during in-hospital resuscitation events. METHODS: An interdisciplinary team developed a 4-hour training session for the family support staff...
December 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/29194463/efficacy-of-endoscopic-balloon-dilation-for-small-bowel-strictures-in-patients-with-crohn-s-disease-a-nationwide-multi-center-open-label-prospective-cohort-study
#13
Fumihito Hirai, Akira Andoh, Fumiaki Ueno, Kenji Watanabe, Naoki Ohmiya, Hiroshi Nakase, Shingo Kato, Motohiro Esaki, Yutaka Endo, Hironori Yamamoto, Toshiyuki Matsui, Mitsuo Iida, Toshifumi Hibi, Mamoru Watanabe, Yasuo Suzuki, Takayuki Matsumoto
Background and Aims: Endoscopic balloon dilation (EBD) is an alternative to surgery for Crohn's strictures. However, there have been no prospective studies of EBD for small bowel strictures in patients with Crohn's disease (CD). The aim of this study was to clarify the efficacy and safety of EBD using balloon-assisted enteroscopy (BAE) for small bowel strictures in CD. Methods: This was a nationwide, multi-center, open-label, prospective cohort study. The subjects were CD patients with at least one symptom (abdominal pain, abdominal bloating, nausea) attributable to small bowel stricture...
November 29, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29187708/-library-construction-from-subnanogram-dna-for-pelagic-sea-water-and-deep-sea-sediments
#14
Miho Hirai, Shinro Nishi, Miwako Tsuda, Michinari Sunamura, Yoshihiro Takaki, Takuro Nunoura
Shotgun metagenomics is a low biased technology for assessing environmental microbial diversity and function. However, the requirement for a sufficient amount of DNA and the contamination of inhibitors in environmental DNA leads to difficulties in constructing a shotgun metagenomic library. We herein examined metagenomic library construction from subnanogram amounts of input environmental DNA from subarctic surface water and deep-sea sediments using two library construction kits: the KAPA Hyper Prep Kit and Nextera XT DNA Library Preparation Kit, with several modifications...
November 28, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/29187693/-a-simple-and-efficient-rna-extraction-method-from-deep-sea-hydrothermal-vent-chimney-structures
#15
Hisashi Muto, Yoshihiro Takaki, Miho Hirai, Sayaka Mino, Shigeki Sawayama, Ken Takai, Satoshi Nakagawa
RNA-based microbiological analyses, e.g., transcriptome and reverse transcription-quantitative PCR, require a relatively large amount of high quality RNA. RNA-based analyses on microbial communities in deep-sea hydrothermal environments often encounter methodological difficulties with RNA extraction due to the presence of unique minerals in and the low biomass of samples. In the present study, we assessed RNA extraction methods for deep-sea vent chimneys that had complex mineral compositions. Mineral-RNA adsorption experiments were conducted using mock chimney minerals and Escherichia coli total RNA solution, and showed that detectable RNA significantly decreased possibly due to adsorption onto minerals...
November 30, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/29187678/additive-value-of-3t-3d-ciss-imaging-to-conventional-mri-for-assessing-the-abnormal-vessels-of-spinal-dural-arteriovenous-fistulae
#16
Hiroyuki Uetani, Toshinori Hirai, Mika Kitajima, Minako Azuma, Shigetoshi Yano, Hideo Nakamura, Keishi Makino, Yutaka Kai, Yasunori Nagayama, Yoshihito Kadota, Yasuyuki Yamashita
INTRODUCTION: We investigated the additive value of the 3T three-dimensional (3D) constructive interference in steady state (CISS) sequence to conventional magnetic resonance imaging (MRI) for the evaluation of spinal dural arteriovenous fistulae (SDAVF). MATERIALS AND METHODS: We included 16 consecutive patients (15 men, 1 woman; age range 42-81 years; mean 64 years) with SDAVF who underwent 3T MRI and digital subtraction angiography (DSA) before treatment. Two neuroradiologists independently evaluated the presence of abnormal vessels on 3D CISS-, T2- and T1-weighted images (T1WI, T2WI), and contrast-enhanced T1WI using a 3-point grading system...
November 29, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29187498/association-between-pd-l1-expression-and-metabolic-activity-on-18f-fdg-pet-ct-in-patients-with-small-sized-lung-cancer
#17
Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Kenichi Kohashi, Takaki Akamine, Shinkichi Takamori, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara
AIM: We evaluated the metabolic characteristics of small-sized lung cancer using 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) with regard to programmed cell death ligand 1 (PD-L1) expression. MATERIALS AND METHODS: PD-L1 expression was evaluated by immunohistochemistry with the antibody clone SP142 in 263 patients with surgically resected primary small-sized lung cancer. Specimens with <5% tumor membrane staining were considered negative...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29187377/a-novel-irreversible-flt3-inhibitor-ff-10101-shows-excellent-efficacy-against-aml-cells-with-flt3-mutations
#18
Takeshi Yamaura, Toshiyuki Nakatani, Ken Uda, Hayato Ogura, Wigyon Shin, Naoya Kurokawa, Koichi Saito, Norie Fujikawa, Tomomi Date, Masaru Takasaki, Daisuke Terada, Atsushi Hirai, Akimi Akashi, Fangli Chen, Yoshiya Adachi, Yuichi Ishikawa, Fumihiko Hayakawa, Shinji Hagiwara, Tomoki Naoe, Hitoshi Kiyoi
An activating mutation of FLT3 is the most frequent genetic alteration associated with poor prognosis in acute myeloid leukemia (AML). Although many FLT3 inhibitors have been clinically developed, no first-generation inhibitors have demonstrated clinical efficacy by monotherapy, due to poor pharmacokinetics or unfavorable safety profiles possibly associated with low selectivity against FLT3 kinase. Recently, a selective FLT3 inhibitor, quizartinib, demonstrated favorable outcomes in clinical studies. However, several resistant mutations emerged during the disease progression...
November 29, 2017: Blood
https://www.readbyqxmd.com/read/29181172/trigeminal-neurofibroma-in-the-infratemporal-fossa-arising-from-the-inferior-alveolar-nerve-a-case-report
#19
Takuro Inoue, Mostafa Elaskary, Ayako Shima, Hisao Hirai, Fumio Suzuki, Masayuki Matsuda
Solitary neurofibromas arising from cranial nerves are rare, and those arising from the peripheral divisions of the trigeminal nerve are even rarer. Although infratemporal fossa (ITF) masses are challenging to remove, certain approaches are considered feasible for this region. The present study reports a rare case of an ITF neurofibroma arising from the inferior alveolar nerve. The 27-year-old male patient presented with numbness of the right jaw. A radiological examination revealed a large mass occupying the ITF, from the mandible to the foramen ovale, originating from the inferior alveolar nerve in the mandible...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29177570/genetic-risk-factors-for-chemotherapy-induced-nausea-and-vomiting-in-patients-with-cancer-receiving-cisplatin-based-chemotherapy
#20
Mari Yokoi, Daiki Tsuji, Kenichi Suzuki, Yohei Kawasaki, Masahiko Nakao, Hideaki Ayuhara, Yuuki Kogure, Kazuhiko Shibata, Toshinobu Hayashi, Keita Hirai, Kazuyuki Inoue, Toshihiro Hama, Koji Takeda, Makoto Nishio, Kunihiko Itoh
PURPOSE: Younger age and female sex have already been well-known risk factors for chemotherapy-induced nausea and vomiting (CINV), and 30-50% of cancer patients still suffer from CINV. Genetic polymorphisms are suggested to influence antiemetic treatment response. METHODS: This study included a subset of patients previously enrolled in a randomised controlled trial; 156 patients were evaluated. This study aimed to evaluate the role of pharmacogenomic polymorphisms relevant to antiemetic response in patients with cancer receiving cisplatin-based chemotherapy...
November 24, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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