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https://www.readbyqxmd.com/read/29666563/do-tsh-ft3-and-ft4-impact-bat-visualization-of-clinical-fdg-pet-ct-images
#1
Ryuichi Nishii, Shigeki Nagamachi, Youichi Mizutani, Tamasa Terada, Syogo Kiyohara, Hideyuki Wakamatsu, Seigo Fujita, Tatsuya Higashi, Keiichiro Yoshinaga, Tsuneo Saga, Toshinori Hirai
Objective: We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH levels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH. Methods: Patients who underwent clinical FDG-PET/CT were reviewed and we categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW) group; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29665624/risk-of-gastrointestinal-bleeding-and-benefit-from-colorectal-cancer-reduction-from-long-term-use-of-low-dose-aspirin-a-retrospective-study-of-612-509-patients
#2
Kelvin K F Tsoi, Felix C H Chan, Hoyee W Hirai, Joseph J Y Sung
BACKGROUND: Aspirin, commonly used for prevention of cardiovascular and cerebrovascular diseases, is well-known to protect against development of colorectal cancer (CRC) but increases risk of gastrointestinal bleeding (GIB). AIM: This cohort study aims to evaluate the benefit of low-dose aspirin to prevent CRC and its associated risk of GIB. METHOD: A population-based dataset was used to compare incidence and mortality of CRC and GIB among patients receiving low-dose aspirin with sex-and-age matched controls (1:2)...
April 17, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29661811/murine-models-of-hepatitis-a-virus-infection
#3
Asuka Hirai-Yuki, Jason K Whitmire, Michael Joyce, D Lorne Tyrrell, Stanley M Lemon
Mechanistic analyses of hepatitis A virus (HAV)-induced pathogenesis have long been thwarted by the lack of tractable small animal models that recapitulate disease observed in humans. Several approaches have shown success, including infection of chimeric mice with human liver cells. Other recent studies show that HAV can replicate to high titer in mice lacking expression of the type I interferon (IFN) receptor (IFN-α/β receptor) or mitochondrial antiviral signaling (MAVS) protein. Mice deficient in the IFN receptor show critical features of type A hepatitis in humans when challenged with human HAV, including histological evidence of liver damage, leukocyte infiltration, and the release of liver enzymes into blood...
April 16, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29660474/decarboxylation-of-indomethacin-induced-by-heat-treatment
#4
Yohsuke Shimada, Haruki Komaki, Ayako Hirai, Satoru Goto, Yasuyuki Hashimoto, Hiromi Uchiro, Hiroshi Terada
As crystalline indomethacin is heated and subsequently cooled, it transforms into glassy indomethacin. While the original crystals are off-white in color, the glass becomes blackish-brown via a yellow intermediate stage. TLC of the components of the glass revealed three bands. The yellow component, which is generated either under hypoxic conditions or in the dark, was elucidated by NMR spectroscopy to be a decarboxylated fragment produced by thermal degradation. The colorless component is proposed to be formed by the opening of the indole ring of indomethacin; the structure of this degradation product was identified by EI-MS to be the same as the oxidative-cleavage product formed upon UV-irradiation, as previously reported...
April 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29659632/correction-enterohemorrhagic-escherichia-coli-o157-subclade-8b-strains-in-chiba-prefecture-japan-produced-larger-amounts-of-shiga-toxin-2-than-strains-in-subclade-8a-and-other-clades
#5
Shinichiro Hirai, Eiji Yokoyama, Taku Wakui, Taichiro Ishige, Masaki Nakamura
[This corrects the article DOI: 10.1371/journal.pone.0191834.].
2018: PloS One
https://www.readbyqxmd.com/read/29658609/survivin-knockdown-induces-senescence-in-ttf%C3%A2-1-expressing-kras-mutant-lung-adenocarcinomas
#6
Toshiyuki Sumi, Sachie Hirai, Miki Yamaguchi, Yusuke Tanaka, Makoto Tada, Gen Yamada, Tadashi Hasegawa, Yohei Miyagi, Toshiro Niki, Atsushi Watanabe, Hiroki Takahashi, Yuji Sakuma
Survivin plays a key role in regulating the cell cycle and apoptosis, and is highly expressed in the majority of malignant tumors. However, little is known about the roles of survivin in KRAS-mutant lung adenocarcinomas. In the present study, we examined 28 KRAS-mutant lung adenocarcinoma tissues and two KRAS-mutant lung adenocarcinoma cell lines, H358 and H441, in order to elucidate the potential of survivin as a therapeutic target. We found that 19 (68%) of the 28 KRAS-mutant lung adenocarcinomas were differentiated tumors expressing thyroid transcription factor‑1 (TTF‑1) and E-cadherin...
April 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29656747/efficacy-and-safety-of-nivolumab-in-previously-treated-patients-with-non-small-cell-lung-cancer-a-multicenter-retrospective-cohort-study
#7
Daichi Fujimoto, Hiroshige Yoshioka, Yuki Kataoka, Takeshi Morimoto, Young Hak Kim, Keisuke Tomii, Tadashi Ishida, Masataka Hirabayashi, Satoshi Hara, Manabu Ishitoko, Yasushi Fukuda, Moon Hee Hwang, Naoki Sakai, Motonari Fukui, Hitoshi Nakaji, Mitsunori Morita, Tadashi Mio, Takehiro Yasuda, Takakazu Sugita, Toyohiro Hirai
INTRODUCTION: Nivolumab has been shown to be effective and safe in previously treated patients with advanced non-small cell lung cancer (NSCLC). However, little is known regarding its performance in real-world (i.e., non-trial) settings. Furthermore, nivolumab efficacy is unknown in patients who are ineligible for clinical trials or who are categorized into small subgroups in such trials. METHODS: We conducted a 15-center, observational, retrospective cohort study of patients with advanced NSCLC who received nivolumab monotherapy between January and December 2016...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29644460/phase-ii-study-of-cisplatin-pemetrexed-combined-with-bevacizumab-followed-by-pemetrexed-bevacizumab-maintenance-therapy-in-patients-with-egfr-wild-advanced-non-squamous-non-small-cell-lung-cancer
#8
Toshirou Fukushima, Yuuki Wakatsuki, Takashi Kobayashi, Kei Sonehara, Kazunari Tateishi, Manabu Yamamoto, Takeshi Masubuchi, Fumiaki Yoshiike, Kazuya Hirai, Tsutomu Hachiya, Tomonobu Koizumi
PURPOSE: This phase II study was performed to evaluate the efficacy and safety of cisplatin/pemetrexed combined with 15 mg/kg of bevacizumab followed by pemetrexed/bevacizumab maintenance therapy as first-line chemotherapy in advanced non-squamous non-small cell lung cancer (NSCLC) limited to epidermal growth factor receptor (EGFR)-wild type. PATIENTS AND METHODS: Fifty patients with advanced or metastatic EGFR-wild type NSCLC aged < 75 years old were enrolled in the study...
April 11, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29643271/japan-diet-intake-changes-serum-phospholipid-fatty-acid-compositions-in-middle-aged-men-a-pilot-study
#9
Yuri Shijo, Chizuko Maruyama, Eri Nakamura, Rena Nakano, Mitsuha Shima, Asumi Mae, Yuuna Okabe, Sunmi Park, Noriko Kameyama, Satomi Hirai
AIM: The Japan Diet nutritional education program effects on serum fatty acid compositions for prevention of atherosclerotic cardiovascular disease in middle-aged men brought up in the westernized dietary environment of modern Japan were examined. METHODS: Thirty-three men, 30-49 years of age, attended a nutrition education class and were recommended to consume Japan Diet volumes (more fish, soybeans and soy products, vegetables, seaweed, konjak, mushrooms, and unrefined cereals and less animal fat, meat and poultry with fat, sweets, desserts and snacks, and alcoholic drinks) for 6 weeks...
April 12, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29623953/erratum-extracellular-%C3%AE-synuclein-induces-sphingosine-1-phosphate-receptor-subtype-1-uncoupled-from-inhibitory-g-protein-leaving-%C3%AE-arrestin-signal-intact
#10
Lifang Zhang, Taro Okada, Shaymaa Mohamed Mohamed Badawy, Chihoko Hirai, Taketoshi Kajimoto, Shun-Ichi Nakamura
This corrects the article DOI: 10.1038/srep44248.
April 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29623951/erratum-impairment-of-pdgf-induced-chemotaxis-by-extracellular-%C3%AE-synuclein-through-selective-inhibition-of-rac1-activation
#11
Taro Okada, Chihoko Hirai, Shaymaa Mohamed Mohamed Badawy, Lifang Zhang, Taketoshi Kajimoto, Shun-Ichi Nakamura
This corrects the article DOI: 10.1038/srep37810.
April 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29621987/distribution-of-ossified-spinal-lesions-in-patients-with-severe-ossification-of-the-posterior-longitudinal-ligament-and-prediction-of-ossification-at-each-segment-based-on-the-cervical-op-index-classification-a-multicenter-study-josl-ct-study
#12
Takashi Hirai, Toshitaka Yoshii, Narihito Nagoshi, Kazuhiro Takeuchi, Kanji Mori, Shuta Ushio, Akio Iwanami, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Soraya Nishimura, Kanichiro Wada, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko Abematsu, Hirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masao Koda, Masashi Yamazaki, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi
BACKGROUND: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification...
April 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29618795/dynamic-changes-in-japan-s-prevalence-of-abnormal-findings-in-cervical-cervical-cytology-depending-on-birth-year
#13
Yutaka Ueda, Asami Yagi, Tomio Nakayama, Kei Hirai, Sayaka Ikeda, Masayuki Sekine, Etsuko Miyagi, Takayuki Enomoto
Japan's governmental recommendation of HPV vaccine has now been suspended for more than 4 years. In and before 2013, the targets of 20-year-old cervical cancer screening were females born in and before 1993, i.e., those who could not have received HPV vaccination because it was not yet publicly introduced. The targets during 2014-2019 are, or will be, those born in 1994-1999, i.e., those who came of age during a period with the highest HPV immunization rate. We analyzed the statistical data for each birth year, for the cumulative HPV vaccination rates achieved as of age 16, and for the corresponding results of cervical cancer screening at age 20...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29618689/-osteonecrosis-developing-after-rituximab-containing-chemotherapy-for-waldenstr%C3%A3-m-macroglobulinemia
#14
Fumihiko Nakamura, Risen Hirai, Takashi Higo, Tomiteru Togano, Rieko Sekine
A 71-year-old woman presented with fever, weight loss, and anemia because of recurrent Waldenström macroglobulinemia (WM) with cryoglobulinemia. Treatment with five cycles of doxorubicin, vincristine, cyclophosphamide, and prednisolone (CHOP) therapy was initiated, which resulted in insufficient improvement in anemia. Hence, a combination of rituximab and CHOP therapy was subsequently initiated. The patient complained of lumbago and lower leg pain on day 4 of the chemoimmunotherapy. X-ray findings for the affected sites were unremarkable, and the patient's symptoms gradually and spontaneously subsided...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29614092/combined-classification-system-based-on-acr-eular-and-ultrasonographic-scores-for-improving-the-diagnosis-of-sj%C3%A3-gren-s-syndrome
#15
Yukinori Takagi, Hideki Nakamura, Misa Sumi, Toshimasa Shimizu, Yasuko Hirai, Yoshiro Horai, Ayuko Takatani, Atsushi Kawakami, Sato Eida, Miho Sasaki, Takashi Nakamura
We retrospectively evaluated the effectiveness of combined use of salivary gland ultrasonography (US) and the 2016 American College of Rheumatology/European League Against Rheumatic Disease (ACR/EULAR) classification criteria for improving the diagnostic efficiency in patients with Sjögren's syndrome (SS). A US-based salivary gland disease grading system was developed using a cohort comprising 213 SS or non-SS patients who fulfilled the minimum requirements for classifying SS based on the American-European Consensus Group (AECG) and ACR criteria...
2018: PloS One
https://www.readbyqxmd.com/read/29607894/high-cardiac-troponin-i-is-associated-with-transesophageal-echocardiographic-risk-of-thromboembolism-and-ischemic-stroke-events-in-non-valvular-atrial-fibrillation-patients
#16
Shuhei Tanaka, Tadakazu Hirai, Kyoko Inao, Nobuyuki Fukuda, Keiko Nakagawa, Hiroshi Inoue, Koichiro Kinugawa
BACKGROUND: Abnormalities in the left atrium (LA) detected on transesophageal echocardiography (TEE) are reliable predictors of thromboembolism in patients with atrial fibrillation (AF). Cardiac troponin I, a marker of subclinical myocardial damage, may also be a predictor of thromboembolic events in patients with AF. The relationship between cardiac troponin I and thromboembolic risk on TEE, however, remains unclear.Methods and Results:TEE and laboratory data, including high sensitivity cardiac troponin I (hs-cTnI) and CHA2 DS2 -VASc score, were analyzed in 199 patients with non-valvular AF (NVAF)...
March 31, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29603260/comparison-between-patients-with-norovirus-related-gastroenteritis-and-asymptomatic-carriers-with-respect-to-distribution-of-antibody-complexed-viral-particles-and-intestinal-flora
#17
Mori Kohji, Konishi Noriko, Suzuki Yasunori, Harada Sachiko, Maeda Masako, Akase Satoru, Obata Hiromi, Monma Chie, Nagano Miyuki, Kimoto Kana, Oda Mayuko, Somura Yoshiko, Hirai Akihiko, Shinkai Takayuki, Noda Mamoru, Sadamasu Kenji
Asymptomatic carriers have a major influence on the spreading of norovirus infections. The objective of this study was to examine the characteristics of patients and asymptomatic carriers affected by norovirus-related community gastroenteritis outbreaks. No significant difference between the two groups was observed in terms of the number of norovirus-antibody complexes with respect to total numbers. Principal coordinates analysis of the intestinal flora based on β-diversity analysis, revealed a different bacterial composition between patients and asymptomatic carriers, particularly regarding the genera Pseudomonas, Bacteroides, and Erwinia, as well as the Ruminococcaceae family...
March 30, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29601633/programmed-death-ligand-1-pd-l1-expression-in-pleomorphic-carcinoma-of-the-lung
#18
Naoko Imanishi, Ayako Hirai, Kazue Yoneda, Shohei Shimajiri, Taiji Kuwata, Yuko Tashima, Masahiro Takeuchi, Yoshiko Iwai, Yoshinobu Ichiki, Fumihiro Tanaka
BACKGROUND AND OBJECTIVES: Pulmonary pleomorphic carcinoma (PPC) is a rare and aggressive subtype of lung cancer. Programmed cell death-ligand 1 (PD-L1) expression may be induced in a variety of malignant tumors, but its prognostic implication in PPC remains unclear. METHODS: Twenty-six patients with surgically resected PPC were retrospectively reviewed. Immuno-histochemical staining was used to detect PD-L1 expression, and PD-L1 status was classified into "high" or "low" according to the percentage of tumor cells (TCs) expressing PD-L1 (tumor proportion score, TPS)...
March 30, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29589208/significance-of-11-c-pib-pet-ct-in-cardiac-amyloidosis-compared-with-99m-tc-aprotinin-scintigraphy-a-pilot-study
#19
Ryogo Minamimoto, Toru Awaya, Kentaro Iwama, Masatoshi Hotta, Kazuhiko Nakajima, Risen Hirai, Osamu Okazaki, Yukio Hiroi
BACKGROUND: This study was to investigate the significance of11 C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with99m Tc-aprotinin scintigraphy. METHODS: Thirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this prospective pilot study. Participants were scheduled to undergo a series of11 C-PIB PET/CT and99m Tc-aprotinin within a 2-month period. Finally, we evaluated nine cases who underwent both imaging modalities, and compared imaging results with clinical and pathological results and prognosis...
March 27, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29576573/diagnostic-reliability-of-3-0-t-mri-for-detecting-osseous-abnormalities-of-the-temporomandibular-joint
#20
Kunihiko Sawada, Toshihiko Amemiya, Shigenori Hirai, Yusuke Hayashi, Toshihiro Suzuki, Masahiko Honda, Johnny Sisounthone, Kunihito Matsumoto, Kazuya Honda
We compared the diagnostic reliability of 3.0-T magnetic resonance imaging (MRI) for detection of osseous abnormalities of the temporomandibular joint (TMJ) with that of the gold standard, cone-beam computed tomography (CBCT). Fifty-six TMJs were imaged with CBCT and MRI, and images of condyles and fossae were independently assessed for the presence of osseous abnormalities. The accuracy, sensitivity, and specificity of 3.0-T MRI were 0.88, 1.0, and 0.73, respectively, in condyle evaluation and 0.91, 0.75, and 0...
2018: Journal of Oral Science
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