keyword
MENU ▼
Read by QxMD icon Read
search

Hirai

keyword
https://www.readbyqxmd.com/read/29027564/correction-to-complete-mucosal-healing-of-distal-lesions-induced-by-twice-daily-budesonide-2-mg-foam-promoted-clinical-remission-of-mild-to-moderate-ulcerative-colitis-with-distal-active-inflammation-double-blind-randomized-study
#1
Makoto Naganuma, Nobuo Aoyama, Tomohiro Tada, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Mamoru Watanabe, Toshifumi Hibi
In Fig. 2(c) of this article, the length of the "95% CI difference bars" under the items labelled "Left-sided and Pancolitis" and "Left-sided" under the heading "Disease type" was corrected. The correct figure is shown in the following page.
October 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29026271/acanthosis-nigricans-in-a-japanese-boy-with-hypochondroplasia-due-to-a-k650t-mutation-in-fgfr3
#2
Hiroki Hirai, Junpei Hamada, Kosei Hasegawa, Eiichi Ishii
Acanthosis nigricans (AN) is observed in some cases of skeletal dysplasia. However, AN has occasionally been reported in patients with hypochondroplasia (HCH), and a clinical diagnosis is sometimes difficult when its physical and radiological features are mild. Mutations in the gene encoding the fibroblast growth factor receptor 3 (FGFR3) have been identified as the cause of some types of skeletal dysplasia, which is diagnostically useful. Here, we report the case of a 3-yr-old Japanese boy who presented with AN...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29025783/syncope-from-radiation-induced-baroreceptor-failure
#3
Scott E Janus, Taishi Hirai, Verghese Mathew, Mark Rabbat
Orthostatic hypotension has a vast differential that has been previously described throughout the literature. However, baroreceptor failure as a sequela of head and neck radiation is not often recognised as an important cause of dramatic haemodynamic variability. As a result, individuals suffering from baroreceptor failure likely have been undertreated. Herein, we report a case of a patient with a history of radiation to the neck for squamous cell carcinoma of the tongue and resultant baroreceptor failure resulting in syncope...
October 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28993883/shaping-somatosensory-responses-in-awake-rats-cortical-modulation-of-thalamic-neurons
#4
Daichi Hirai, Kouichi C Nakamura, Ken-Ichi Shibata, Takuma Tanaka, Hiroyuki Hioki, Takeshi Kaneko, Takahiro Furuta
Massive corticothalamic afferents originating from layer 6a of primary sensory cortical areas modulate sensory responsiveness of thalamocortical neurons and are pivotal for shifting neuronal firing between burst and tonic modes. The influence of the corticothalamic pathways on the firing mode and sensory gain of thalamic neurons has only been extensively examined in anesthetized animals, but has yet to be established in the awake state. We made lesions of the rat barrel cortex and on the following day recorded responses of single thalamocortical and thalamic reticular neurons to a single vibrissal deflection in the somatosensory system during wakefulness...
October 9, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28986696/progression-level-of-extracapsular-spread-and-tumor-budding-for-cervical-lymph-node-metastasis-of-oscc
#5
Shin-Ichi Yamada, Mitsunobu Otsuru, Souichi Yanamoto, Takumi Hasegawa, Hitoshi Aizawa, Takahiro Kamata, Nobuhiro Yamakawa, Tomoyuki Kohgo, Akira Ito, Yuri Noda, Chihoko Hirai, Tetsuya Kitamura, Masaya Okura, Tadaaki Kirita, Michihiro Ueda, Tetsuro Yamashita, Yoshihide Ota, Takahide Komori, Masahiro Umeda, Hiroshi Kurita
OBJECTIVES: The progression level of extracapsular spread (ECS) for cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) was previously divided into three types, and their relationships with the prognosis of patients were re-examined. PATIENTS AND METHODS: The Kaplan-Meier method was used to examine overall survival (OS) and relapse-free survival (RFS) curves. Prognosis factor for recurrence was analyzed with univariate and multivariate analysis...
October 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28982914/surgical-resection-and-outcome-of-synchronous-and-metachronous-primary-lung-cancer-in-breast-cancer-patients
#6
Fumihiro Shoji, Nami Yamashita, Yuka Inoue, Yuka Kozuma, Gouji Toyokawa, Fumihiko Hirai, Kensaku Ito, Tetsuzo Tagawa, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND/AIM: Women with breast cancer are at increased risk of subsequent primary malignancies, specifically lung cancer. The aim of this study was to report the frequency of lung cancer in patients with breast cancer, and patients' characteristics and surgical outcomes. PATIENTS AND METHODS: We investigated 1,066 consecutive female patients undergoing surgical resection for breast cancer and 666 undergoing surgical resection for lung cancer. RESULTS: Lung cancer with breast cancer was observed in 14 patients (1...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982107/risk-factor-for-vital-signs-fluctuation-during-colonoscopy-under-conscious-sedation-consisting-of-midazolam-and-meperidine
#7
Shigeo Banno, Motohiko Kato, Yukie Sunata, Yuichiro Hirai, Yoko Kubosawa, Keiichiro Abe, Yoshiaki Takada, Tetsu Hirata, Yusaku Takatori, Michiko Wada, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Masahiro Kikuchi, Toshio Uraoka
BACKGROUND: Sedatives or analgesics are widely used to relieve a patient's discomfort during colonoscopy (CS). Although cardiopulmonary adverse events are sometimes experienced during the examination, the risk factors for vital signs fluctuation (VSF) have not been fully elucidated. This study thus aimed to identify the risk factors for VSF during the examination, as well as to evaluate the frequency and the degree of VSF. SUMMARY: A total of 755 consecutive subjects who received CS under endoscopist-administrated sedation using midazolam, meperidine, or combination of both were retrospectively analyzed...
October 6, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28980178/a-typical-carcinoid-tumor-of-the-lung-presenting-with-pure-persistent-ground-glass-opacity-on-high-resolution-computed-tomography-a-case-report
#8
Masafumi Yamaguchi, Fumihiko Hirai, Kenichi Taguchi, Ryo Toyozawa, Makoto Edagawa, Shinichiro Shimamatsu, Kaname Nosaki, Takashi Seto, Mitsuhiro Takenoyama, Yukito Ichinose
Pure ground-glass opacity nodules (p-GGN) on high-resolution computed tomography (HRCT) generally have been considering typically associated with adenocarcinoma with less invasive nature. We herein reported a patient presenting focal p-GGN on middle lobe of the right lung who underwent surgical resection with its pathological diagnosis turned out to be typical carcinoid tumor.
October 4, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28977788/x-chromosome-introgression-and-recombination-in-the-cephus-group-of-cercopithecus-monkeys
#9
Anthony J Tosi, Hirohisa Hirai
A representative of Cercopithecus erythrotis was surveyed at a 9.3-kb region of the X chromosome. The data were compared against homologous sequences of closely related Cercopithecus monkeys including C. cephus, a species recently shown to have 2 polymorphic X-chromosomal lineages. Direct sequence comparisons and subsequent phylogenetic analyses revealed that synapomorphies in the first 4.3 kb cluster C. erythrotis with one C. cephus lineage, while synapomorphies in the latter 5.0 kb join it with the second C...
October 5, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28976848/effect-of-oxygen-inhibition-layer-of-universal-adhesives-on-enamel-bond-fatigue-durability-and-interfacial-characteristics-with-different-etching-modes
#10
H Ouchi, A Tsujimoto, K Nojiri, K Hirai, T Takamizawa, W W Barkmeier, M A Latta, M Miyazaki
OBJECTIVE: The purpose of this study was to evaluate the effect of the oxygen inhibition layer of universal adhesive on enamel bond fatigue durability and interfacial characteristics with different etching modes. METHODS: The three universal adhesives used were Scotchbond Universal Adhesive (3M ESPE, St Paul, MN, USA), Adhese Universal (Ivoclar Vivadent, Schaan, Lichtenstein), and G-Premio Bond (GC, Tokyo, Japan). The initial shear bond strength and shear fatigue strength to enamel was determined in the presence and absence of the oxygen inhibition layer, with and without phosphoric acid pre-etching...
October 4, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28971147/statins-decrease-vascular-epithelial-growth-factor-expression-via-down-regulation-of-receptor-for-advanced-glycation-end-products
#11
Hiroki Tsujinaka, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Ryogo Shobatake, Mai Makino, Naonori Masuda, Hiromasa Hirai, Shin Takasawa, Nahoko Ogata
AIMS: Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, possess pleiotropic effects that have been extended to modulation of various cellular behaviors. This study aimed to examine whether statins modulate vascular endothelial growth factor A (VEGF-A) expression in human retinal pigment epithelium (RPE) cells. MAIN METHODS: Human RPE cells (h1RPE7), damaged by hydroquinone (HQ) + advanced glycation endproducts (AGE) in an in vitro AMD model, were treated with atorvastatin or lovastatin for 24 h...
September 2017: Heliyon
https://www.readbyqxmd.com/read/28967890/long-term-expansion-of-alveolar-stem-cells-derived-from-human-ips-cells-in-organoids
#12
Yuki Yamamoto, Shimpei Gotoh, Yohei Korogi, Masahide Seki, Satoshi Konishi, Satoshi Ikeo, Naoyuki Sone, Tadao Nagasaki, Hisako Matsumoto, Shigeo Muro, Isao Ito, Toyohiro Hirai, Takashi Kohno, Yutaka Suzuki, Michiaki Mishima
The stable expansion of tissue-specific stem cells in vitro has contributed to research on several organs. Alveolar epithelial type II (AT2) cells function as tissue stem cells in the lung, but robust models for studying human AT2 cells are lacking. Here we report a method for the efficient generation and long-term expansion of alveolar organoids (AOs) harboring SFTPC(+) alveolar stem cells derived from human induced pluripotent stem cells (hiPSCs). hiPSC-derived SFTPC(+) cells self-renewed, with transcriptomes and morphology consistent with those of AT2 cells, and were able to differentiate into alveolar epithelial type I (AT1)-like cells...
October 2, 2017: Nature Methods
https://www.readbyqxmd.com/read/28966958/salient-features-and-outline-of-the-joint-japanese-guidelines-for-safe-handling-of-cancer-chemotherapy-drugs
#13
Kiyoko Kanda, Kazue Hirai, Keiko Iino, Hisanaga Nomura, Hisateru Yasui, Taro Kano, Chisato Ichikawa, Sumiko Hiura, Tomoko Morita, Ayako Mitsuma, Hiroko Komatsu
The purpose of this paper is to introduce the outline and describe the salient features of the "Joint Guidelines for Safe Handling of Cancer Chemotherapy Drugs" (hereinafter, "Guideline"), which were published in July 2015. The purpose of this Guideline is to provide guidance to protect against occupational exposure to hazardous drugs (HDs) to all medical personnel involved in cancer chemotherapy, including physicians, pharmacists, and nurses and home health-care providers. The Guideline was developed according to the Medical Information Network Distribution Service guidance for developing clinical practice guidelines, with reference to five authoritative guidelines used worldwide...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28966237/inhibitory-effects-of-gastrointestinal-drugs-on-cyp-activities-in-human-liver-microsomes
#14
Mariko Iwase, Yuki Nishimura, Norimitsu Kurata, Hokuto Namba, Takahito Hirai, Yuji Kiuchi
OTC drugs have an important role in self-medication. However, the pharmacokinetic properties of some OTC drugs have not been fully investigated and reports concerning their drug interactions are insufficient. Several gastrointestinal drugs are available as OTC drugs. Because of their pharmacological properties, these drugs are often used concomitantly with other drugs. Therefore, it is important to predict the possible drug interactions among these drugs. In the current study, we investigated the inhibitory effects of five gastrointestinal drugs, namely loperamide, oxethazaine, papaverine, pirenzepine, and trimebutine, on CYP activities in human liver microsomes...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28961520/food-poisoning-outbreak-in-tokyo-japan-caused-by-staphylococcus-argenteus
#15
Yasunori Suzuki, Hiroaki Kubota, Hisaya K Ono, Makiko Kobayashi, Konomi Murauchi, Rei Kato, Akihiko Hirai, Kenji Sadamasu
Staphylococcus argenteus is a novel species subdivided from Staphylococcus aureus. Whether this species can cause food poisoning outbreaks is unknown. This study aimed to investigate the enterotoxigenic activities of two food poisoning isolates suspected to be S. argenteus (Tokyo13064 and Tokyo13069). The results for phylogenic trees, constructed via whole genome sequencing, demonstrated that both isolates were more similar to a type strain of S. argenteus (MSHR1132) than any S. aureus strain. Moreover, the representative characteristics of S...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28960780/changes-in-the-breath-sound-spectrum-during-methacholine-inhalation-in-children-with-asthma
#16
Hideyuki Tabata, Mayumi Enseki, Mariko Nukaga, Kota Hirai, Shinichi Matsuda, Hiroyuki Furuya, Masahiko Kato, Hiroyuki Mochizuki
BACKGROUND AND OBJECTIVE: An effort-independent breath sound analysis is expected to be a safe and simple method for clinical assessment of changes in airway function. The effects of bronchoconstriction and bronchodilation on novel breath sound parameters in asthmatic children were investigated. METHODS: The study population included 49 children with atopic asthma (male = 33; mean age: 10.2 years). We evaluated breath sound parameters of the highest frequency of the power spectrum (HFp), frequency limiting 50% and 99% of the power spectrum (F50 and F99 ) and roll-off from 600 Hz to the HFp (Slope)...
September 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28949274/determination-of-the-time-course-of-caloric-nystagmus-in-patients-with-spinocerebellar-degeneration-using-caloric-step-stimulus-procedure
#17
Takamori Takeda, Ayane Makabe, Chiaki Hirai, Takeshi Tsutsumi
CONCLUSIONS: The step stimulus procedure can provide information on the time course of the vestibulo-ocular reflex. Spinocerebellar degeneration and aging seem to shorten the time constant of the onset of the vestibulo-ocular reflex, causing a rapid rise up. Failure of the central processing of velocity storage might contribute to this rapid rise up. OBJECTIVES: The aim of this study is to evaluate the time course characteristics of the vestibulo-ocular reflex in patients with spinocerebellar degeneration...
September 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28948536/anatomical-variations-of-the-recurrent-artery-of-heubner-number-origin-and-course
#18
Wakoto Matsuda, Takahiro Sonomura, Satoru Honma, Sachi Ohno, Tetsuya Goto, Shuichi Hirai, Masahiro Itoh, Yoshiko Honda, Hiroki Fujieda, Jun Udagawa, Shuichi Ueda
The clinical anatomy of the recurrent artery of Heubner (RAH) was examined, focusing on its number, origin, and course, in a large number of brain specimens. We studied 724 RAH in total from 357 brain specimens (714 hemispheres). In 98.74 % of 714 cases there were one or more RAHs, while it was absent in 1.26 % of cases. There was a single RAH in 96.22 % of cases, double in 2.38 % of cases, and triple in 0.14 % of cases. In this study, three origin types of the RAH were defined. We defined A1 and A2 segment of the anterior cerebral artery (ACA) as the artery from the origin of the ACA to the junction of the anterior communicating artery (AComA) and the artery from the junction of the AComA to the anterior border of the corpus callosum, respectively...
September 25, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28943571/mycobacterium-wolinskyi-peritonitis-after-peritoneal-catheter-embedment-surgery
#19
Hiroyuki Fujikura, Kei Kasahara, Yoshihiko Ogawa, Nobuyasu Hirai, Seiya Yoshii, Shingo Yoshihara, Taku Ogawa, Shinsuke Yonekawa, Natsuko Imakita, Yuichi Nishioka, Tatsuo Yoneda, Katsunori Yoshida, Ken-Ichi Samejima, Kaori Tanabe, Yoshihiko Saito, Hisakazu Yano, Keiichi Mikasa
Mycobacterium wolinskyi belongs to the Mycobacterium smegmatis group, which comprises rapidly growing non-tuberculous mycobacteria. The number of case reports on M. wolinskyi infections associated with postoperative wounds has increased in recent years. We herein report a case of peritonitis due to M. wolinskyi after peritoneal catheter embedment surgery. Identification was achieved based on 16S ribosomal RNA and rpoB gene sequencing of the isolate. The patient recovered following catheter removal and treatment with levofloxacin and minocycline for one month...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28938615/biomarker-immunoprofile-in-salivary-duct-carcinomas-clinicopathological-and-prognostic-implications-with-evaluation-of-the-revised-classification
#20
Soichiro Takase, Satoshi Kano, Yuichiro Tada, Daisuke Kawakita, Tomotaka Shimura, Hideaki Hirai, Kiyoaki Tsukahara, Akira Shimizu, Yorihisa Imanishi, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Yukiko Sato, Chihiro Fushimi, Takuro Okada, Hiroki Sato, Kuninori Otsuka, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Takafumi Togashi, Yushi Ueki, Hisayuki Ota, Toyoyuki Hanazawa, Hideaki Chazono, Robert Yoshiyuki Osamura, Toshitaka Nagao
Salivary duct carcinoma (SDC) is an uncommon, aggressive malignant neoplasm histologically resembling high-grade mammary ductal carcinoma. SDC can arise de novo or ex pleomorphic adenoma. To clarify the correlation of biomarker immunoprofile with clinicopathological findings and clinical outcome of SDC, we conducted immunohistochemistry for EGFR, HER2, HER3, AR, CK5/6, p53, and Ki-67, along with HER2 fluorescence in situ hybridization in 151 SDCs. SDCs ex pleomorphic adenoma more commonly overexpressed EGFR, HER2, HER3, and Ki-67 than de novo SDCs (P = 0...
August 29, 2017: Oncotarget
keyword
keyword
39468
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"