Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Lucas Tröger, Florian Goirand, Karen Alim
Many cells face search problems, such as finding food, mates, or shelter, where their success depends on their search strategy. In contrast to other unicellular organisms, the slime mold Physarum polycephalum forms a giant network-shaped plasmodium while foraging for food. What is the advantage of the giant cell on the verge of multicellularity? We experimentally study and quantify the migration behavior of P. polycephalum plasmodia on the time scale of days in the absence and presence of food. We develop a model which successfully describes its migration in terms of ten data-derived parameters...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America
#22
JOURNAL ARTICLE
Javiera Rosell, Alvaro Vergés, Claudia Miranda-Castillo
No abstract text is available yet for this article.
March 22, 2024: Global Health Promotion
#23
JOURNAL ARTICLE
Laura Koskenvuo, Pipsa Lunkka, Pirita Varpe, Marja Hyöty, Reetta Satokari, Carola Haapamäki, Anna Lepistö, Ville Sallinen
IMPORTANCE: Surgical site infections (SSIs)-especially anastomotic dehiscence-are major contributors to morbidity and mortality after rectal resection. The role of mechanical and oral antibiotics bowel preparation (MOABP) in preventing complications of rectal resection is currently disputed. OBJECTIVE: To assess whether MOABP reduces overall complications and SSIs after elective rectal resection compared with mechanical bowel preparation (MBP) plus placebo. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, double-blind, placebo-controlled randomized clinical trial was conducted at 3 university hospitals in Finland between March 18, 2020, and October 10, 2022...
March 20, 2024: JAMA Surgery
#24
REVIEW
Carlos M Farinha, Lúcia Santos, João F Ferreira
Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is a complex process that starts with its biosynthesis and folding in the endoplasmic reticulum. Exit from the endoplasmic reticulum (ER) is coupled with the acquisition of a compact structure that can be processed and traffic through the secretory pathway. Once reaching its final destination-the plasma membrane, CFTR stability is regulated through interaction with multiple protein partners that are involved in its post-translation modification, connecting the channel to several signaling pathways...
2024: Frontiers in Cell and Developmental Biology
#25
JOURNAL ARTICLE
Alexander Sturm, Grzegorz Jóźwiak, Marta Pla Verge, Laura Munch, Gino Cathomen, Anthony Vocat, Amanda Luraschi-Eggemann, Clara Orlando, Katja Fromm, Eric Delarze, Michał Świątkowski, Grzegorz Wielgoszewski, Roxana M Totu, María García-Castillo, Alexandre Delfino, Florian Tagini, Sandor Kasas, Cornelia Lass-Flörl, Ronald Gstir, Rafael Cantón, Gilbert Greub, Danuta Cichocka
Antimicrobial resistance (AMR) is a major public health threat, reducing treatment options for infected patients. AMR is promoted by a lack of access to rapid antibiotic susceptibility tests (ASTs). Accelerated ASTs can identify effective antibiotics for treatment in a timely and informed manner. We describe a rapid growth-independent phenotypic AST that uses a nanomotion technology platform to measure bacterial vibrations. Machine learning techniques are applied to analyze a large dataset encompassing 2762 individual nanomotion recordings from 1180 spiked positive blood culture samples covering 364 Escherichia coli and Klebsiella pneumoniae isolates exposed to cephalosporins and fluoroquinolones...
March 18, 2024: Nature Communications
#26
JOURNAL ARTICLE
Joshua D Eisenberg, Rebecca P Bradley, Kahleb D Graham, Rachel H Ceron, Amanda M Lemke, Benjamin J Wilkins, Ali Naji, Robert O Heuckeroth
BACKGROUND AND AIMS: Hirschsprung disease is defined by the absence of enteric nervous system (ENS) from distal bowel. Primary treatment is "pull-through" surgery to remove bowel that lacks ENS with re-anastomosis of "normal" bowel near the anal verge. Problems after pull-through are common and some may be due to retained hypoganglionic bowel (i.e., low ENS density). Testing this hypothesis has been difficult because counting enteric neurons in tissue sections is unreliable even for experts...
March 15, 2024: Gastroenterology
#27
JOURNAL ARTICLE
Yasong Guo, Wendy Y Chen
Urban trees have attracted increasing attention to serve as a green prescription for addressing various challenges facing human society like climate change and environmental deterioration. However, without healthy growth of urban trees, they cannot service any environmental, social, and economic benefits in a sustainable manner. By monitoring the canopy development, the tree growth dynamics in different urban habitats can be detected and appropriate management approaches can be executed. Using the Kowloon Peninsula, Hong Kong, as a case, this study explores how remote sensing data can help monitor and understand the impacts of heterogeneous urban habitats on tree canopy dynamics...
March 15, 2024: Journal of Environmental Management
#28
JOURNAL ARTICLE
Jiahao Zhou, Jun Huang, Zikai Zhou, Xiangbing Deng, Qingbin Wu, Ziqiang Wang
PURPOSE: Total neoadjuvant therapy (TNT) has emerged as a therapeutic approach for locally advanced rectal cancer (LARC). However, the optimal chemotherapy cycles within TNT remain uncertain. This study aimed to evaluate and compare the prognostic efficacy of varying cycles of chemotherapy during TNT for LARC. METHODS: Patients diagnosed with LARC (T3-4N0M0/T1-4N1-2M0), who underwent TNT or chemoradiotherapy followed by total mesorectal excision (TME) between 2015 and 2020, were retrospective included...
March 16, 2024: International Journal of Colorectal Disease
#29
JOURNAL ARTICLE
Shu-Zhen Xu, Zhen-Fa Wang, Zhi-Jie Ding, Shi-Feng Zhang, Si-Bo Yuan, Feng Yan, Guo-Yan Liu, Jian-Chun Cai
BACKGROUND: Natural orifice specimen extraction surgery (NOSES) is currently widely used in left-sided colorectal cancer. Some clinical comparative studies have been conducted, providing evidence of its safety and oncological benefits. However, these studies are typically characterized by small sample sizes and short postoperative follow-up periods. Consequently, in this research, the authors adopt the propensity score matching method to undertake a large-scale retrospective comparative study on NOSES colectomy for left-sided colorectal cancer, with the goal of further augmenting the body of evidence-based medical support for NOSES...
March 1, 2024: International Journal of Surgery
#30
JOURNAL ARTICLE
William M de Souza, Marcilio J Fumagalli, Shirlene T S de Lima, Pierina L Parise, Deyse C M Carvalho, Cristian Hernandez, Ronaldo de Jesus, Jeany Delafiori, Darlan S Candido, Victor C Carregari, Stefanie P Muraro, Gabriela F Souza, Leda M Simões Mello, Ingra M Claro, Yamilka Díaz, Rodrigo B Kato, Lucas N Trentin, Clauber H S Costa, Ana Carolina B M Maximo, Karene F Cavalcante, Tayna S Fiuza, Vânia A F Viana, Maria Elisabeth L Melo, Clarissa P M Ferraz, Débora B Silva, Larissa M F Duarte, Priscilla P Barbosa, Mariene R Amorim, Carla C Judice, Daniel A Toledo-Teixeira, Mariana S Ramundo, Patricia V Aguilar, Emerson L L Araújo, Fabio T M Costa, Thiago Cerqueira-Silva, Ricardo Khouri, Viviane S Boaventura, Luiz Tadeu M Figueiredo, Rong Fang, Brechla Moreno, Sandra López-Vergès, Liana Perdigão Mello, Munir S Skaf, Rodrigo R Catharino, Fabiana Granja, Daniel Martins-de-Souza, Jessica A Plante, Kenneth S Plante, Ester C Sabino, Michael S Diamond, Eliseo Eugenin, José Luiz Proença-Módena, Nuno R Faria, Scott C Weaver
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi-organ infection, central nervous system damage, and elevated serum levels of pro-inflammatory cytokines and chemokines compared with survivors...
March 8, 2024: Cell Host & Microbe
#31
JOURNAL ARTICLE
Franz Wegner, Thomas Friedrich, Maximilian Wattenberg, Justin Ackers, Malte Maria Sieren, Roman Kloeckner, Joerg Barkhausen, Thorsten M Buzug, Matthias Graeser, Anselm von Gladiss
PURPOSE: Magnetic particle imaging (MPI) is an emerging medical imaging modality that is on the verge of clinical use. In recent years, cardiovascular applications have shown huge potential like, e.g., intraprocedural imaging guidance of stent placement through MPI. Due to the lack of signal generation, nano-modifications have been necessary to visualize commercial medical instruments until now. In this work, it is investigated if commercial interventional devices can be tracked with MPI without any nano-modification...
2024: International Journal of Nanomedicine
#32
JOURNAL ARTICLE
Mohd Rahil Hasan, Pradakshina Sharma, Saumitra Singh, Jagriti Narang
Smartphones' widespread availability and worldwide connection are advancing the idea of mobile-based healthcare and promise to transform the business of biosensors. Biosensors based on smartphones have been investigated in several ways, including employing a smartphone in place of a detector or as an instrumental interface. The current work demonstrates the first successful detection of dengue virus using a smartphone-based pocket sensor combined with a wireless potentiostat. The platform developed comprises a smartphone, a wireless portable potentiostat, an Android app, and a three-electrode setup...
March 12, 2024: ACS Applied Bio Materials
#33
JOURNAL ARTICLE
Aurore Mitaine, Gauthier Duloquin, Thibaut Pommier, Catherine Vergely, Charles Guenancia, Yannick Béjot
BACKGROUND: Atrial fibrillation (AF) is frequently diagnosed during the acute stage of ischemic (IS), and it may reflect undiagnosed AF before stroke, thus representing a missed opportunity for stroke prevention. This population-based study aimed to assess the prevalence of known AF (KAF) and AF diagnosed early after IS (AFDAS), and to compare clinical and brain/arterial imaging characteristics between patients. METHODS: Among patients with acute IS recorded in the population-based Dijon Stroke Registry, France (2013-2020), we identified those with KAF or AFDAS...
March 12, 2024: Neuroepidemiology
#34
JOURNAL ARTICLE
Thomas K S Tiang, Adrian S S Yeoh, Bushra Othman, Helen M Mohan, Adele N Burgess, Philip J Smart, David M Proud
AIM: The optimal management of patients with clinical complete response after neoadjuvant treatment for rectal cancer is controversial. The aim of this study is to compare the morbidity between patients with locally advanced rectal cancer who have had a pathological complete response (pCR) or not after neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision (TME). The study hypothesis was that pCR may impact the surgical complication rate. METHOD: A retrospective cohort study was conducted of a prospectively maintained database in Australia and New Zealand, the Binational Colorectal Cancer Audit, that identified patients with locally advanced rectal cancer (<15 cm from anal verge) from 1 January 2007 to 31 December 2019...
March 11, 2024: Colorectal Disease
#35
JOURNAL ARTICLE
Ricardo Aguilar, Sandra López-Vergès, Anarellys Quintana, Johanna Morris, Lineth Lopez, Ana Cooke, Dimas Quiel, Natalie Buitron, Yaseikiry Pérez, Lesbia Lobo, Maura Ballesteros, Yaneth Pitti, Yamilka Diaz, Lisseth Saenz, Danilo Franco, Daniel Castillo, Elimelec Valdespino, Isabel Blanco, Emilio Romero, Alcibiades Villarreal, Idalina Cubilla-Batista
BACKGROUND: At the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, transfusion of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) emerged as a potential therapeutic strategy to help patients severely afflicted by COVID-19. The efficacy of CCP has been controversial as it depends on many variables pertaining to the plasma donor and the patient with COVID-19, for example, time of convalescence or symptoms onset. This feasibility and descriptive study aimed to assess the safety of multiple doses of CCP in mechanically ventilated, intubated patients with respiratory failure due to COVID-19...
March 2024: Health Science Reports
#36
MULTICENTER STUDY
Zhengyang Yang, Jiale Gao, Jianyong Zheng, Jiagang Han, Ang Li, Gang Liu, Yi Sun, Jie Zhang, Guangyong Chen, Rui Xu, Xiao Zhang, Yishan Liu, Zhigang Bai, Wei Deng, Wei He, Hongwei Yao, Zhongtao Zhang
Adding PD-1 blockade in the neoadjuvant regimens for locally advanced rectal cancer (LARC) patients with microsatellite stable (MSS) / mismatch repair-proficient (pMMR) tumors is an attractive, but debatable strategy. This phase 2, multicenter, prospective, single-arm study enrolled patients from 6 centers from June 2021 to November 2022. Locally advanced rectal cancer (LARC, cT3-4a N0 M0 and cT1-4a N1-2 M0 ) patients aged ≥18 years with the distance from distal border of tumor to anal verge ≤10 cm (identified by Magnetic Resonance Imaging) were qualified for inclusion...
March 11, 2024: Signal Transduction and Targeted Therapy
#37
JOURNAL ARTICLE
Francesc Marginedas, Josep Maria Vergès, Palmira Saladié, Antonio Rodríguez-Hidalgo
In this manuscript, we explore the potential of studying metal residues in cut marks generated by copper and bronze knives. The method was developed in the forensic sciences for use with modern metals in order to identify microscopic particles of metal tools on bone surfaces. However, the study of residues in archaeological materials can be challenging due to the ways in which the bone remains may have been manipulated, both in the past and in more recent times. Using a scanning electron microscope (SEM), we detected microscopic fragments of bronze and copper knives along with contamination both inside and outside of the cut marks made by those knives...
February 26, 2024: Micron
#38
JOURNAL ARTICLE
Pierre-Henri Moury, Alexandre Béhouche, Sébastien Bailly, Zoé Durand, Géraldine Dessertaine, Angelina Pollet, Samir Jaber, Samuel Verges, Pierre Albaladejo
BACKGROUND: The incidence, causes and impact of diaphragm thickness evolution in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock are unknown. Our study investigates its evolution during the first week of VA-ECMO and its relationship with sweep gas flow settings. METHODS: We conducted a prospective monocentric observational study in a 12-bed ICU in France, enrolling patients on the day of the VA-ECMO implantation. The diaphragm thickness and the diaphragm thickening fraction (as index of contractile activity, dTF; dTF < 20% defined a low contractile activity) were daily measured for one week using ultrasound...
March 8, 2024: Annals of Intensive Care
#39
JOURNAL ARTICLE
C Quivoron, J-M Michot, A Danu, H Lecourt, V Saada, K Saleh, V Vergé, S Cotteret, O A Bernard, V Ribrag
As a promising alternative to bone marrow aspiration (BMA), mutational profiling on blood-derived circulating cell-free tumor DNA (cfDNA) is a harmless and simple technique to monitor molecular response and treatment resistance of patients with refractory/relapsed multiple myeloma (R/R MM). We evaluated the sensitivity and specificity of cfDNA compared to BMA CD138 positive myeloma plasma cells (PCs) in a series of 45 R/R MM patients using the 29-gene targeted panel (AmpliSeq) NGS. KRAS , NRAS , FAM46C , DIS3 , and TP53 were the most frequently mutated genes...
March 3, 2024: Leukemia & Lymphoma
#40
REVIEW
Alexis Litchinko, Nicolas Buchs, Alexandre Balaphas, Christian Toso, Emilie Liot, Guillaume Meurette, Frédéric Ris, Jeremy Meyer
OBJECTIVE: Predicting the risk of anastomotic leak (AL) is of importance when defining the optimal surgical strategy in colorectal surgery. Our objective was to perform a systematic review of existing scores in the field. METHODS: We followed the PRISMA checklist (S1 Checklist). Medline, Cochrane Central and Embase were searched for observational studies reporting on scores predicting AL after the creation of a colorectal anastomosis. Studies reporting only validation of existing scores and/or scores based on post-operative variables were excluded...
February 28, 2024: Surgical Endoscopy
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
