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Atiq Hassan, Breanna M Arnold, Sally Caine, Behzad M Toosi, Valerie M K Verge, Gillian D Muir
One of the most promising approaches to improve recovery after spinal cord injury (SCI) is the augmentation of spontaneously occurring plasticity in uninjured neural pathways. Acute intermittent hypoxia (AIH, brief exposures to reduced O2 levels alternating with normal O2 levels) initiates plasticity in respiratory systems and has been shown to improve recovery in respiratory and non-respiratory spinal systems after SCI in experimental animals and humans. Although the mechanism by which AIH elicits its effects after SCI are not well understood, AIH is known to alter protein expression in spinal neurons in uninjured animals...
2018: PloS One
Sajad Hasanzadeh, Seyedeh Maryam Alavi, Elahe Masnavi, Maryam Rohani, Saeid Jokar
Background: Polyarteritis nodosa (PAN) is a vasculitis that affects medium sized arteries. PAN is a rare disease and requires a high vilgilance for diagnosis. For instance, PAN and Henoch-Schonlein purpura (HSP) have narrowing differential diagnosis. Here, we report a case of PAN. Case presentation : Our patient was a 65 year old woman that came to hospital due to abdominal pain and skin lesion on the right upper and right lower extremities. All rheumatologic tests were negative. A biopsy of the skin lesion was reported as mild hyperkeratosis, slight spongiosis with intact basal layer...
2018: F1000Research
Jenifer Barrie, Adam Haque, David Andrew Evans
AIM: Extralevator abdominoperineal resection (ELAP) may be complicated by perineal wound healing problems and herniation. We report a consecutive series of 38 such patients with selective use of a fasciocutaneous V-Y buttock advancement flap (BAF). METHOD: Data were collected on a series of patients undergoing ELAP for rectal malignancy between August 2011 and July 2017. Demographics, management and outcomes were recorded prospectively. Perineal wound problems were considered 'major' if they required packing, otherwise being classed as 'minor'...
May 12, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
B Siddeek, N Li, C Mauduit, H Chehade, E Rigal, J-F Tolsa, J-B Armengaud, C Yzydorczyk, M Benahmed, C Vergely, U Simeoni
BACKGROUND AND AIMS: The prevalence of obesity is increasing worldwide at an alarming rate. Altered early nutrition, in particular postnatal overfeeding (PNOF), is a risk factor for impaired cardiac function in adulthood. In the understanding of the initiation or progression of heart diseases, NLRP3 inflammasome and non-coding RNAs have been proposed as key players. In this context, the aim of this study was to decipher the role of NLRP3 inflammasome and its post transcriptional control by micro-RNAs in the regulation of cardiac metabolic function induced by PNOF in mice...
April 14, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Mark Saban
Given his lifelong battle against one-sidedness Jung's persistent prioritising of the 'inner life' over the 'outer' can seem problematic. The question is raised as to whether an approach that seems to verge uncomfortably close to solipsism can sometimes render Jung blind to the intuition that psychic life is constituted by an on-going interplay between inner and outer, self and other (an intuition that he himself sometimes articulated so brilliantly). The 'ambiguation' of Jung's work offers an opportunity to confront this problem by utilising a critical dynamic that is consistent with Jung's psychological insights...
June 2018: Journal of Analytical Psychology
Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Jaime Lora-Tamayo, Laura Morata, Oscar Murillo, Helem Vilchez, Luisa Sorli, Laura Guío Carrión, José Mª Barbero, Julián Palomino-Nicás, Alberto Bahamonde, Alfredo Jover-Sáenz, Natividad Benito, Rosa Escudero, Marta Fernandez- Sampedro, Rafael Pérez Vidal, Lucía Gómez, Pablo S Corona, Benito Almirante, Javier Ariza, Carles Pigrau
BACKGROUND: Candida periprosthetic joint infection (CPJI) is a rare, difficult-to-treat disease. The purpose of this study was to evaluate the clinical characteristics and outcomes of CPJI treated with various surgical and antifungal strategies. METHODS: We conducted a multicenter retrospective study of all CPJI diagnosed between 2003 and 2015 in 16 Spanish hospitals. RESULTS: Forty-three patients included: median age, 75 years, and median Charlson Comorbidity Index score, 4...
May 7, 2018: Journal of Infection
Ming-Jung Liu, Koichi Sugimoto, Sahra Uygun, Nicholas Panchy, Michael S Campbell, Mark Yandell, Gregg A Howe, Shin-Han Shiu
The evolution of transcriptional regulatory mechanisms is central to how stress response and tolerance differ between species. However, it remains largely unknown how divergence in cis-regulatory sites and, subsequently, transcription factor (TF) binding specificity contribute to stress-responsive expression divergence, particularly between wild and domesticated spe-cies. By profiling wound-responsive gene transcriptomes in wild Solanum pennellii and do-mesticated S. lycopersicum, we found extensive wound-response divergence and identified 493 S...
May 9, 2018: Plant Cell
Karl S Benz, Emily Dunn, Meiyappan Solaiyappan, Mahir Maruf, Matthew Kasprenski, John Jayman, Jason E Michaud, James Facciola, John P Gearhart
PURPOSE: Understanding the distinct female anatomy in classic bladder exstrophy is crucial for optimal reconstructive and functional outcomes. This study presents novel quantitative anatomical data in females with classic bladder exstrophy prior to primary closure. MATERIALS AND METHODS: Patients underwent three-dimensional reconstruction of pelvic magnetic resonance imaging studies, and pelvic anatomy was characterized, including measurements of the vagina, cervix, and erectile bodies...
April 30, 2018: Journal of Urology
Diana M Falkenbach, Justin Balash, Maria Tsoukalas, Stephanie Stern, Scott O Lilienfeld
The majority of psychopathy research has focused on negative outcomes in criminal populations. However, psychopathy encompasses a variety of traits, and recent research suggests that certain features of psychopathy, such as a fearless temperament, may be related to psychological resiliency, "successful" functioning, and even heroic behavior (Hall & Benning, 2006; Lykken, 1995). Despite anecdotal discussion, little is known about the possible "successful" or adaptive reflections of psychopathic personality traits in ostensible heroes...
May 3, 2018: Personality Disorders
Jing Xin Li, Li Yang, Lei Yang, Chao Zhang, Zhao Min Huo, Min Hao Chen, Xiao Feng Luan
Quantitative evaluation of ecosystem service is a primary premise for rational resources exploitation and sustainable development. Examining ecosystem services flow provides a scientific method to quantity ecosystem services. We built an assessment indicator system based on land cover/land use under the framework of four types of ecosystem services. The types of ecosystem services flow were reclassified. Using entropy theory, disorder degree and developing trend of indicators and urban ecosystem were quantitatively assessed...
March 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
William Tzu-Liang Chen, Saurabh Bansal, Tao-Wei Ke, Sheng-Chi Chang, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, Abe Fingerhut
BACKGROUND: Few clear recommendations exist for the management of colorectal anastomotic leaks, often based on surgeon preferences or institutional protocols. The primary goal was to evaluate the feasibility and safety of the combined laparoscopic and transanal (hybrid) approach to treat postoperative colorectal anastomotic leaks. The secondary goals included comparison of outcomes following early (< 5 days after initial resection) versus late (≥ 5 days) detection of leaks...
May 1, 2018: Surgical Endoscopy
Arbin Joshi
Gastrointestinal Stromal Tumour involving rectum and anal canal is an extremely rare entity. This is a case report of a 47 years lady presented with fresh rectal bleed associated with rectal pain and foul smelling rectal mucus discharge. On rectal examination, she had a firm mass palpable about 1.5 cm from anal verge. Considering the size of the tumour and its close proximity with cervix and involvement of levator muscles, extralevator abdominal perineal excision of rectum was undertaken with good recovery after surgery...
March 13, 2018: Journal of Nepal Health Research Council
Pierre Verger, Aurélie Bocquier, Chantal Vergélys, Jeremy Ward, Patrick Peretti-Watel
BACKGROUND: Vaccination against seasonal influenza (SIV) is recommended for patients with diabetes, but their vaccination coverage is unsatisfactory in France and elsewhere. This qualitative survey of people with diabetes sought to explore 1) the extent to which SIV-related behaviour is more or less automatic; 2) reasons they choose/reject SIV; 3) their trust/distrust in authorities, science, and medicine. METHODS: We conducted semi-structured in-depth interviews of 19 adults with diabetes in 2014...
May 2, 2018: BMC Public Health
Philippe Besnard, Jeffrey E Christensen, Hélène Brignot, Arnaud Bernard, Patricia Passilly-Degrace, Sophie Nicklaus, Jean-Paul Pais de Barros, Xavier Collet, Benjamin Lelouvier, Florence Servant, Vincent Blasco, Bruno Verges, Laurent Lagrost, Gilles Feron, Rémy Burcelin
Some obese subjects overeat lipid-rich foods. The origin of this eating behavior is unknown. We have here tested the hypothesis that these subjects could be characterized by an impaired fatty taste sensitivity linked to a change in the gustatory papillae microbial and salivary environment. The composition of microbiota and saliva surrounding the circumvallate papillae was analyzed in combination with the orosensory lipid detection threshold in normal weight (NW) and obese (O) adults. Microbial architecture was similar to what was known in feces, but with an increased frequency of Proteobacteria...
April 30, 2018: Scientific Reports
Isaac Perea-Gil, Carolina Gálvez-Montón, Cristina Prat-Vidal, Ignasi Jorba, Cristina Segú-Vergés, Santiago Roura, Carolina Soler-Botija, Oriol Iborra-Egea, Elena Revuelta-López, Marco A Fernández, Ramon Farré, Daniel Navajas, Antoni Bayes-Genis
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. We developed two engineered cardiac grafts, based on decellularized scaffolds from myocardial and pericardial tissues and repopulated them with adipose tissue mesenchymal stem cells (ATMSCs). The structure, macromechanical and micromechanical scaffold properties were preserved upon the decellularization and recellularization processes, except for recellularized myocardium micromechanics that was ∼2-fold stiffer than native tissue and decellularized scaffolds...
April 30, 2018: Scientific Reports
Xavier Serra-Aracil, Raquel Gràcia, Laura Mora-López, Sheila Serra-Pla, Anna Pallisera-Lloveras, Maritxell Labró, Salvador Navarro-Soto
BACKGROUND: The aim of this study is to assess postoperative morbidity and mortality in tumors with a proximal margin 15 cm or more from the anal verge operated with transanal endoscopic microsurgery (TEM). METHODS: This observational study of consecutive rectal tumor patients undergoing TEM was carried out from July 2004 to June 2017. We compared the results of rectal tumors at distances of ≥15 cm (group A) and <15 cm (group B) from the anal verge. RESULTS: During the study period 667 patients were included: 118 in group A and 549 in group B...
April 22, 2018: American Journal of Surgery
A Bressan, L Marini, M Michelotto, A C Frigo, G Da Dalt, S Merigliano, L Polese
AIM: The aim of this study was to investigate risk factors for anastomotic stenosis in patients operated on for diverticular disease. Histological inflammation and diverticula at the resection margins were also considered. METHOD: Patients' characteristics, the surgical technique and post-operative complications were collected from the medical records. Anastomotic stenoses were evaluated prospectively by rigid sigmoidoscopy during follow-up examinations. Histological specimens were examined by a single pathologist who investigated inflammation and diverticula at the resection margins...
April 28, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Cesar Tovar, Amanda L Patchett, Vitna Kim, Richard Wilson, Jocelyn Darby, A Bruce Lyons, Gregory M Woods
The Tasmanian devil (Sarcophilus harrisii), the largest extant carnivorous marsupial and endemic to Tasmania, is at the verge of extinction due to the emergence of a transmissible cancer known as devil facial tumour disease (DFTD). DFTD has spread over the distribution range of the species and has been responsible for a severe decline in the global devil population. To protect the Tasmanian devil from extinction in the wild, our group has focused on the development of a prophylactic vaccine. Although this work has shown that vaccine preparations using whole DFTD tumour cells supplemented with adjuvants can induce anti-DFTD immune responses, alternative strategies that induce stronger and more specific immune responses are required...
2018: PloS One
Monique Mendelson, Mathieu Marillier, Sébastien Bailly, Patrice Flore, Jean-Christian Borel, Isabelle Vivodtzev, Stéphane Doutreleau, Renaud Tamisier, Jean-Louis Pépin, Samuel Verges
Maximal aerobic capacity is a strong health predictor and peak oxygen consumption (VO2peak ) is considered a reflection of total body health. No systematic reviews or meta-analysis' to date have synthesised the existing data regarding VO2peak in patients with obstructive sleep apnoea (OSA).A systematic review of English and French articles using Pubmed/Medline and Embase included studies assessing VO2peak of OSA patients in mL·kg-1 ·min-1 compared with controls or in % predicted. Two independent reviewers analysed the studies, extracted the data and assessed the quality of evidence...
April 26, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
K Gaur, P Sakhuja, R N Mandal, S Kapoor
Indian childhood cirrhosis is an entity believed to be on the verge of extinction. We present the case of a 13-month-old girl presenting acutely with jaundice, fever, and persistently increasing bilirubin. Investigations revealed direct hyperbilirubinemia, elevated transaminases, anemia, a blood with few schistocytes, positive direct coombs test, and deranged prothrombin time. Viral, autoimmune, and metabolic workup was unremarkable. Ultrasonography showed chronic liver disease, portal hypertension, and ascites...
April 2018: Journal of Postgraduate Medicine
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