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https://www.readbyqxmd.com/read/28630462/identification-and-molecular-characterization-of-non-polio-enteroviruses-from-children-with-acute-flaccid-paralysis-in-west-africa-2013-2014
#1
Maria D Fernandez-Garcia, Ousmane Kebe, Aichatou D Fall, Kader Ndiaye
Besides polioviruses, non-polio enteroviruses (NPEVs) may also be associated with acute flaccid paralysis (AFP). Because poliomyelitis is on the verge of eradication, more attention should be paid to study NPEVs from non-polio AFP cases and their epidemic patterns. In West African countries the epidemiology of NPEVs remains largely unexplored. We investigated the genetic diversity, frequency, circulation patterns, and molecular epidemiology of NPEVs in seven West African countries by analyzing retrospectively a panel of 3195 stool samples from children with AFP collected through routine poliomyelitis surveillance activities between 2013 and 2014...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628565/open-versus-laparoscopic-surgery-for-advanced-low-rectal-cancer-a-large-multicenter-propensity-score-matched-cohort-study-in-japan
#2
Koya Hida, Ryosuke Okamura, Yoshiharu Sakai, Tsuyoshi Konishi, Tomonori Akagi, Tomohiro Yamaguchi, Takashi Akiyoshi, Meiki Fukuda, Seiichiro Yamamoto, Michio Yamamoto, Tatsuto Nishigori, Kenji Kawada, Suguru Hasegawa, Satoshi Morita, Masahiko Watanabe
BACKGROUND: Laparoscopic surgery for rectal cancer is widely performed all over the world and several randomized controlled trials have been reported. However, the usefulness of laparoscopic surgery compared with open surgery has not been demonstrated sufficiently, especially for the low rectal area. OBJECTIVE: The aim of this study was to investigate the hypothesis that laparoscopic primary tumor resection is safe and effective when compared with the open approach for locally advanced low rectal cancer...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28620675/sphincter-preserving-surgery-for-low-rectal-cancers-incidence-and-risk-factors-for-permanent-stoma
#3
Joanna Chung Kiu Mak, Dominic Chi Chung Foo, Rockson Wei, Wai Lun Law
BACKGROUND: Advances in surgical techniques and paradigm changes in rectal cancer treatment have led to a drastic decline in the abdominoperineal resection rate, and sphincter-preserving operation is possible in distal rectal cancer. OBJECTIVE: The aim of this study is to evaluate the long-term incidence of permanent stoma after sphincter-preserving surgery for low rectal cancer and its corresponding risk factors. METHOD: From 2000 to 2014, patients who underwent sphincter-preserving low anterior resection for low rectal cancer (within 5 cm from the anal verge) were included...
June 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28617575/external-influences-on-invertebrate-brain-histamine-and-related-compounds-via-an-automated-derivatization-method-for-capillary-electrophoresis
#4
Sandrine Parrot, Mónica Pavón Vergés, Marie-Jeanne Perrot-Minnot, Luc Denoroy
Histamine has been shown to modulate visual system and photic behavior in arthropods. However, few methods are available for the direct quantification of histamine and its precursor and metabolites in arthropod brain. In this work, a method for the separation of histamine, its precursor histidine and its metabolite N-methyl-histamine from brain extracts of a freshwater crustacean has been developed using capillary electrophoresis with laser-induced fluorescence detection. Molecules were tagged on their primary amine function with naphthalene-2,3-dicarboxaldehyde, but derivatized histamine and N-methyl-histamine exhibited poor stability in contrast to derivatized histidine...
June 15, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28614168/glove-port-transanal-excision-of-rectal-tumors-an-alternative-method-for-rectal-tumor-excision-single-center-experience
#5
Sridhar Dharamavaram, Dimple Sapre, Ahmed M A Mohammed, Krishnamurthy Badrinath
AIM: Transanal minimal invasive surgery has been practiced for several years for excision of rectal tumors however there is no standard consensus about its applications. This minimally invasive approach helps in avoiding major rectal resections and its associated risk of mortality and morbidity.The aim of this study is to describe a single center experience with transanal glove port excision of rectal tumors which are not amenable to colonoscopic excision. MATERIALS AND METHODS: Between the years 2011 and 2014, 9 patients underwent glove port excision of rectal tumors located within 15 cm from the anal verge...
June 13, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28611535/biological-subtypes-of-triple-negative-breast-cancer
#6
REVIEW
Michael Hubalek, Theresa Czech, Hannes Müller
Triple-negative breast cancers (TNBCs) are defined as tumors that are negative for estrogen, progesterone and HER-2 receptor. At a percentage of 10-20% TNBCs represent a minority in all breast cancers. However, because of the poor prognosis this particular subtype, triple negative disease accounts for a disproportionate number of metastatic cases and breast cancer deaths. Identification of its subtypes is essential for understanding the biological characteristics and clinical behavior of TNBC, as well as for developing personalized treatments...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28611272/a-case-report-of-hepatocellular-carcinoma-5-years-after-hbsag-loss-in-chronic-hepatitis-delta-how-long-surveillance-is-required
#7
Laura Escolà-Vergé, Mar Riveiro-Barciela, Maria Buti
BACKGROUND: Hepatitis delta virus infection occurs as acute co-infection or as superinfection in patients with preexisting chronic hepatitis B. Chronic hepatitis delta leads to more severe disease than chronic hepatitis B, with more rapid progression of fibrosis and increased risk of hepatocelullar carcinoma. CASE REPORT: We report a case of hepatocelullar carcinoma 5 years after spontaneous clearance of Hepatitis B surface antigen in a patient with previous chronic hepatitis delta...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28610935/prone-positioning-reduces-perineal-infections-when-performing-the-miles-procedure
#8
Anne M Dinaux, Ramzi Amri, David L Berger
BACKGROUND: Abdominoperineal resection (APR) remains the cornerstone treatment for rectal cancers less than 5 cm from the anal verge. The perineal portion of an APR can be done with the patient in lithotomy or repositioned to prone jack-knife position, which influences accessibility, visualization and ability to close the wound. This paper analyses the effect of patient positioning on perineal wound dehiscence and infections. METHODS: A retrospective review of all rectal cancer patients who underwent an APR at Massachusetts General Hospital between 2004 and 2014 (n = 149)...
June 10, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28601342/organ-preservation-for-rectal-cancer-greccar-2-a-prospective-randomised-open-label-multicentre-phase-3-trial
#9
Eric Rullier, Philippe Rouanet, Jean-Jacques Tuech, Alain Valverde, Bernard Lelong, Michel Rivoire, Jean-Luc Faucheron, Mehrdad Jafari, Guillaume Portier, Bernard Meunier, Igor Sileznieff, Michel Prudhomme, Frédéric Marchal, Marc Pocard, Denis Pezet, Anne Rullier, Véronique Vendrely, Quentin Denost, Julien Asselineau, Adélaïde Doussau
BACKGROUND: Organ preservation is a concept proposed for patients with rectal cancer after a good clinical response to neoadjuvant chemotherapy, to potentially avoid morbidity and side-effects of rectal excision. The objective of this study was to compare local excision and total mesorectal excision in patients with a good response after chemoradiotherapy for lower rectal cancer. METHODS: We did a prospective, randomised, open-label, multicentre, phase 3 trial at 15 tertiary centres in France that were experts in the treatment of rectal cancer...
June 7, 2017: Lancet
https://www.readbyqxmd.com/read/28597987/trafficking-and-localization-to-the-plasma-membrane-of-nav-1-5-promoted-by-the-%C3%AE-2-subunit-is-defective-due-to-a-%C3%AE-2-mutation-associated-with-brugada-syndrome
#10
Gemma Dulsat, Sonia Palomeras, Eric Cortada, Helena Riuró, Ramon Brugada, Marcel Vergés
BACKGROUND INFORMATION: Cardiac channelopathies arise by mutations in genes encoding ion channel subunits. One example is Brugada Syndrome (BrS), which causes arrhythmias and sudden death. BrS is often associated with mutations in SCN5A, encoding Nav 1.5, the α subunit of the major cardiac voltage-gated sodium channel. This channel forms a protein complex including one or two associated β subunits as well as other proteins. RESULTS: We analyzed regulation of Nav 1...
June 9, 2017: Biology of the Cell
https://www.readbyqxmd.com/read/28596408/draft-genome-sequence-of-serratia-proteamaculans-mfpa44a14-05-a-model-organism-for-the-study-of-meat-and-seafood-spoilage
#11
Lysiane Fougy, Gwendoline Coeuret, Marie-Christine Champomier-Vergès, Stéphane Chaillou
In this study, we present a draft genome sequence of Serratia proteamaculans MFPA44A14-05. This strain was isolated from a spoiled organic modified-atmosphere-packed beef carpaccio. The draft genome sequence will contribute to the understanding of the role of the S. proteamaculans species in meat and seafood spoilage.
June 8, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28596137/reshaping-antibiotics-through-hydrophobic-drug-bile-acid-ionic-complexation-enhances-activity-against-staphylococcus-aureus-biofilms
#12
Stefano Giovagnoli, Donatella Pietrella, Lanfranco Barberini, Claudio Santi, Andrea Carotti, Alessandro di Michele, Maurizio Ricci
The antibiotic era is on the verge of a profound change and facing a ground shaking crisis. The frequent failures of antibiotic treatments are often associated with biofilm formation, which is responsible for chronic infections, exacerbation as well as reinfection. So far, albeit the large number of valuable strategies employed to combat biofilm formation, little success has been recorded. In this work, we propose a simple approach, based on hydrophobic ionic complexation with the bile acids, deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA), to enhance anti-biofilm activity of well-known antibiotics, namely kanamycin (K), amikacin (A) and vancomycin (V)...
June 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28592219/early-risk-of-recurrent-stroke-in-patients-with-symptomatic-carotid-near-occlusion-results-from-caos-a-multicenter-registry-study
#13
Andrés García-Pastor, Antonio Gil-Núñez, José María Ramírez-Moreno, Noelia González-Nafría, Javier Tejada, Francisco Moniche, Juan Carlos Portilla-Cuenca, Patricia Martínez-Sánchez, Blanca Fuentes, Miguel Ángel Gamero-García, María Alonso de Leciñana, David Cánovas-Verge, Yolanda Aladro, Vera Parkhutik, Aida Lago-Martín, Ana María de Arce-Borda, María Usero-Ruíz, Raquel Delgado-Mederos, Ana Pampliega, Álvaro Ximenez-Carrillo, Mónica Bártulos-Iglesias, Enrique Castro-Reyes
Background The risk of recurrent stroke among patients with symptomatic carotid near-occlusion is not well established, and management of the condition remains controversial. Symptomatic carotid near-occlusion with full collapse has been identified as a strong predictor of early recurrence. We aimed to analyze the 90-day risk of recurrent ipsilateral ischemic stroke in medically treated patients with symptomatic carotid near-occlusion. Methods We performed a multicenter, nationwide, prospective study from January 2010 to May 2016...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28585890/hypoxic-conditioning-and-the-central-nervous-system-a-new-therapeutic-opportunity-for-brain-and-spinal-cord-injuries
#14
S Baillieul, S Chacaroun, S Doutreleau, O Detante, J L Pépin, S Verges
Central nervous system diseases are among the most disabling in the world. Neuroprotection and brain recovery from either acute or chronic neurodegeneration still represent a challenge in neurology and neurorehabilitation as pharmacology treatments are often insufficiently effective. Conditioning the central nervous system has been proposed as a potential non-pharmacological neuro-therapeutic. Conditioning refers to a procedure by which a potentially deleterious stimulus is applied near to but below the threshold of damage to the organism to increase resistance to the same or even different noxious stimuli given above the threshold of damage...
June 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28579289/effects-of-anti-somatostatin-agents-on-glucose-metabolism
#15
REVIEW
B Vergès
The anti-somatostatin agents used to treat acromegaly, Cushing's disease and neuroendocrine tumours also have hyperglycaemic effects. This is particularly true for pasireotide. Hyperglycaemic events are seen in 57-73% of patients with Cushing's treated with pasireotide, with a need to initiate antidiabetic treatment in about 50% of these patients. In acromegaly, treatment with pasireotide induces hyperglycaemia in 29-61% of patients. Pasireotide-induced hyperglycemia occurs early, within the first 3 months of treatment, due to a decrease in insulin secretion secondary to a fall in secretion of GLP-1 and GIP, and potentially also due to a direct inhibitory effect of pasireotide on beta cells...
June 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28569553/effects-of-combined-exercise-training-and-electromyostimulation-treatments-in-chronic-heart-failure-a-prospective-multicentre-study
#16
Marie C Iliou, Bénédicte Vergès-Patois, Bruno Pavy, Anais Charles-Nelson, Catherine Monpère, Rudy Richard, Jean C Verdier
Background Exercise training as part of a comprehensive cardiac rehabilitation is recommended for patients with cardiac heart failure. It is a valuable method for the improvement of exercise tolerance. Some studies reported a similar improvement with quadricipital electrical myostimulation, but the effect of combined exercise training and electrical myostimulation in cardiac heart failure has not been yet evaluated in a large prospective multicentre study. Purpose The aim of this study was to determine whether the addition of low frequency electrical myostimulation to exercise training may improve exercise capacity and/or muscular strength in cardiac heart failure patients...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28568902/managing-consequences-of-climate-driven-species-redistribution-requires-integration-of-ecology-conservation-and-social-science
#17
Timothy C Bonebrake, Christopher J Brown, Johann D Bell, Julia L Blanchard, Alienor Chauvenet, Curtis Champion, I-Ching Chen, Timothy D Clark, Robert K Colwell, Finn Danielsen, Anthony I Dell, Jennifer M Donelson, Birgitta Evengård, Simon Ferrier, Stewart Frusher, Raquel A Garcia, Roger B Griffis, Alistair J Hobday, Marta A Jarzyna, Emma Lee, Jonathan Lenoir, Hlif Linnetved, Victoria Y Martin, Phillipa C McCormack, Jan McDonald, Eve McDonald-Madden, Nicola Mitchell, Tero Mustonen, John M Pandolfi, Nathalie Pettorelli, Hugh Possingham, Peter Pulsifer, Mark Reynolds, Brett R Scheffers, Cascade J B Sorte, Jan M Strugnell, Mao-Ning Tuanmu, Samantha Twiname, Adriana Vergés, Cecilia Villanueva, Erik Wapstra, Thomas Wernberg, Gretta T Pecl
Climate change is driving a pervasive global redistribution of the planet's species. Species redistribution poses new questions for the study of ecosystems, conservation science and human societies that require a coordinated and integrated approach. Here we review recent progress, key gaps and strategic directions in this nascent research area, emphasising emerging themes in species redistribution biology, the importance of understanding underlying drivers and the need to anticipate novel outcomes of changes in species ranges...
June 1, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28565912/are-electron-affinity-and-ionization-potential-intrinsic-parameters-to-predict-the-electron-or-hole-acceptor-character-of-amorphous-molecular-materials
#18
Enrique Louis, Emilio San-Fabián, María A Díaz-García, Guillermo Chiappe, José A Vergés
No abstract text is available yet for this article.
June 1, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28557459/phonon-assisted-two-photon-interference-from-remote-quantum-emitters
#19
Marcus Reindl, Klaus D Jöns, Daniel Huber, Christian Schimpf, Yongheng Huo, Val Zwiller, Armando Rastelli, Rinaldo Trotta
Photonic quantum technologies are on the verge of finding applications in everyday life with quantum cryptography and quantum simulators on the horizon. Extensive research has been carried out to identify suitable quantum emitters and single epitaxial quantum dots have emerged as near-optimal sources of bright, on-demand, highly indistinguishable single photons and entangled photon-pairs. In order to build up quantum networks, it is essential to interface remote quantum emitters. However, this is still an outstanding challenge, as the quantum states of dissimilar "artificial atoms" have to be prepared on-demand with high fidelity and the generated photons have to be made indistinguishable in all possible degrees of freedom...
June 7, 2017: Nano Letters
https://www.readbyqxmd.com/read/28557294/a-mechanism-for-nav-1-5-downregulation-and-sodium-current-decrease-in-heart-failure
#20
EDITORIAL
Sara Pagans, Marcel Vergés
The pore-forming α-subunit of the cardiac voltage-gated sodium channel, NaV 1.5, is responsible for the initial upstroke of the cardiac action potential. NaV 1.5 cell surface expression and function are modulated by its interaction with regulatory proteins and by posttranslational modifications, such as phosphorylation, arginine methylation or ubiquitination (1) . Genetic mutations in the SCN5A gene, which encodes NaV 1.5, have been associated with a variety of inherited cardiac arrhythmias, including long QT syndrome type 3, Brugada syndrome, atrial fibrillation, and congenital sick sinus syndrome...
May 30, 2017: Acta Physiologica
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