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https://www.readbyqxmd.com/read/28938543/predictive-clinical-model-of-tumor-response-after-chemoradiation-in-rectal-cancer
#1
Marisa D Santos, Cristina Silva, Anabela Rocha, Carlos Nogueira, Fernando Castro-Poças, António Araujo, Eduarda Matos, Carina Pereira, Rui Medeiros, Carlos Lopes
Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28924962/the-impact-of-tumour-distance-from-the-anal-verge-on-clinical-management-and-outcomes-in-patients-having-a-curative-resection-for-rectal-cancer
#2
Muhammad Amir Saeed Khan, Chin W Ang, Abdul Rahman Hakeem, Nigel Scott, Rick Nigel Saunders, Ian Botterill
AIM: The clinico-oncological significance of the distance of rectal cancer from the anal verge is unclear and not well reported. The aim of this study is to assess the influence of the rectal cancer distance from the anal verge on clinical management and long-term outcomes after curative resection in a specialised colorectal cancer unit. METHODS: Prospectively collected data on patients who underwent primary rectal cancer treatment at our unit between January 2005 and December 2010 were analysed...
September 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28913985/asthma-biomarkers-do-they-bring-precision-medicine-closer-to-the-clinic
#3
REVIEW
Ioana Agache, Liliana Rogozea
Measurement of biomarkers has been incorporated within clinical research of asthma to characterize the population and to associate the disease with environmental and therapeutic effects. Regrettably, at present, there are no specific biomarkers, none is validated or qualified, and endotype-driven choices overlap. Biomarkers have not yet reached clinical practice and are not included in current asthma guidelines. Last but not least, the choice of the outcome upholding the value of the biomarkers is extremely difficult, since it has to reflect the mechanistic intervention while being relevant to both the disease and the particular person...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28900991/-transanal-endoscopic-microsurgery-for-treatment-of-rectal-neuroendocrine-tumors
#4
Qianqian Shao, Guole Lin, Huizhong Qiu
OBJECTIVE: To assess the efficacy of full-thickness excision using transanal endoscopic microsurgery (TEM) in the treatment of rectal neuroendocrine tumors (NET). METHODS: Clinicopathological and follow-up data of 90 rectal NET patients who underwent TEM between December 2006 and December 2016 at our department were retrospectively analyzed. TEM was performed as primary excision in 66 patients and as the second complete surgery because of suspected positive margin of samples after colonoscopic polypectomy in 24 patients...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28891039/a-systematic-review-of-transabdominal-levator-division-during-abdominoperineal-excision-of-the-rectum-aper
#5
D L H Baird, C Simillis, C Kontovounisios, Q Sheng, S Nikolaou, W L Law, S Rasheed, P P Tekkis
BACKGROUND: The aim of the present study was to evaluate the surgical technique, short-term oncological and perioperative outcomes for the transabdominal division of the levator ani muscles during abdominoperineal excision of the rectum (APER). METHODS: A systematic review was performed to identify studies reporting on transabdominal division of the levator ani during APER. A comprehensive literature search was performed using a combination of free-text terms and controlled vocabulary when applicable on the following databases: MEDLINE, EMBASE, Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library...
September 11, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28890654/chondroitin-sulfate-inhibits-monocyte-chemoattractant-protein-1-release-from-3t3-l1-adipocytes-a-new-treatment-opportunity-for-obesity-related-inflammation
#6
Thomas V Stabler, Eulàlia Montell, Josep Vergés, Janet L Huebner, Virginia Byers Kraus
Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. 3T3-L1 embryonic fibroblasts were cultured and differentiated into adipocytes using an established protocol. Adipocytes were treated with lipopolysaccharide (LPS) to induce inflammation and thus MCP-1 release. At the same time, varying concentrations of chondroitin sulfate (CS) were added in a physiologically relevant range (10-200 µg/mL) to determine its impact on MCP-1 release...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28878171/lactobacillus-sakei-a-starter-for-sausage-fermentation-a-protective-culture-for-meat-products
#7
REVIEW
Monique Zagorec, Marie-Christine Champomier-Vergès
Among lactic acid bacteria of meat products, Lactobacillus sakei is certainly the most studied species due to its role in the fermentation of sausage and its prevalence during cold storage of raw meat products. Consequently, the physiology of this bacterium regarding functions involved in growth, survival, and metabolism during meat storage and processing are well known. This species exhibits a wide genomic diversity that can be observed when studying different strains and on which probably rely its multiple facets in meat products: starter, spoiler, or protective culture...
September 6, 2017: Microorganisms
https://www.readbyqxmd.com/read/28877810/the-ferguson-operating-anoscope-for-resection-of-t1-rectal-cancer
#8
Kristin C Turza, Thomas Brien, Steven Porbunderwala, Christopher M Bell, Shauna Lorenzo-Rivero, Richard A Moore, Eric C Nelson, J Daniel Stanley
The Ferguson Operating Anoscope (FOA) is a surgical instrument, which can facilitate transanal excision of appropriate rectal tumors within 15 cm of the anal verge. Previous work showed low recurrence (4.3%) for favorable T1 tumors (no lymphovascular invasion, well/moderate differentiation, negative margins). This follow-up study evaluates outcomes in rectal cancer excised with FOA at a tertiary care center. T1 rectal cancer patients were identified in a prospectively maintained database. Tumor pathology and patient characteristics were reviewed...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28871476/peritoneal-perforation-is-less-a-complication-than-an-expected-event-during-transanal-endoscopic-microsurgery-experience-from-194-consecutive-cases
#9
D Mege, N Petrucciani, L Maggiori, Y Panis
BACKGROUND: Indications for transanal endoscopic microsurgery (TEM) have been extended to technically challenging tumors, which may be associated with an increased risk of peritoneal perforation (PP). The aim of the present study was to investigate the occurrence, management and outcome of PP in patients having TEM. METHODS: All the patients who had TEM for rectal adenoma or adenocarcinoma in our unit were included. Patients in whom PP occurred (Group A) were compared to those without PP (Group B)...
September 4, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28870718/four-year-experience-of-providing-mobile-extracorporeal-life-support-to-out-of-center-patients-within-a-suprainstitutional-network-outcome-of-160-consecutively-treated-patients
#10
Hug Aubin, George Petrov, Hannan Dalyanoglu, Maximillian Richter, Diyar Saeed, Payam Akhyari, Detlef Kindgen-Milles, Alexander Albert, Artur Lichtenberg
AIM: Mobile extracorporeal life support (ECLS) may soon be on the verge to become a fundamental part of emergency medicine. Here, we report on our four-year experience of providing advanced mechanical circulatory support for out-of-center patients within the Düsseldorf ECLS Network (DELSN). METHODS: This retrospective cohort study analyses the outcome of 160 patients with refractory circulatory failure consecutively treated with mobile veno-arterial extracorporeal membrane oxygenation (vaECMO) between July 2011 and October 2015 within the DELSN...
September 11, 2017: Resuscitation
https://www.readbyqxmd.com/read/28867489/optomechanical-devices-for-deep-plasma-cancer-proteomics
#11
REVIEW
Priscila M Kosaka, Montserrat Calleja, Javier Tamayo
Most of the cancer deaths could be avoided by early detection of the tumor when it is confined to its primary site and it has not metastasized. To this aim, one of the most promising strategies is the discovery and detection of protein biomarkers shed by the young tumor to the bloodstream. Proteomic technologies, mainly mass spectrometry and multiplexed immunoassays, have rapidly developed during last years with improved limits of detection and multiplexing capability. Unfortunately, these developments together major investments and large international efforts have not resulted into new useful protein biomarkers...
August 31, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28867452/the-role-of-osteoprotegerin-in-the-crosstalk-between-vessels-and-bone-its-potential-utility-as-a-marker-of-cardiometabolic-diseases
#12
REVIEW
Luc Rochette, Alexandre Meloux, Eve Rigal, Marianne Zeller, Yves Cottin, Catherine Vergely
Among the numerous molecules that are being studied for their potential utility as biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of tumor necrosis factor (TNF) receptors. Members of this family include osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). These signals may be expressed and regulated, and their functions could be involved in several physiological and pathological processes...
September 1, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28855915/genotypic-diversity-and-short-term-response-to-shading-stress-in-a-threatened-seagrass-does-low-diversity-mean-low-resilience
#13
Suzanna M Evans, Adriana Vergés, Alistair G B Poore
Seagrasses that are predominantly clonal often have low levels of genetic variation within populations and predicting their response to changing conditions requires an understanding of whether genetic variation confers increased resistance to environmental stressors. A higher level of genetic diversity is assumed to benefit threatened species due to the increased likelihood of those populations having genotypes that can persist under environmental change. To test this idea, we conducted an in situ shading experiment with six geographically distinct meadows of the threatened seagrass Posidonia australis that vary in genetic diversity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28852963/minimal-residual-disease-eradication-in-cml-does-it-really-matter
#14
REVIEW
Srinivas K Tantravahi, Raga S Guthula, Thomas O'Hare, Michael W Deininger
BCR-ABL1 tyrosine kinase inhibitors (TKIs) have improved the prognosis of chronic phase chronic myeloid leukemia (CP-CML) to an extent that survival is largely determined by non-CML mortality. Monitoring for minimal residual disease by measuring BCR-ABL1 messenger RNA is a key component of CML management. CP-CML patients who achieve a stable deep molecular response may discontinue (TKIs) with an ~ 50% chance of entering treatment-free remission (TFR). So far discontinuation of TKIs has largely been limited to clinical trials, but is on the verge of becoming a part of wider clinical practice...
August 29, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28845063/spread-of-water-borne-pollutants-at-traffic-accidents-on-roads
#15
Bo Olofsson, Hedi Rasul, Annika Lundmark
Traffic accidents sometimes lead to the spread of hazardous compounds to the environment. Accidental spills of hazardous compounds on roads in the vicinity of vulnerable objects such as water supplies pose a serious threat to water quality and have to be assessed. This study compared three different assessment methods, electrical resistivity measurements, analytical flow calculations, and 1D and 2D dynamic flow modeling, to describe rapid transport processes in the road shoulder and roadside verge after a major spill...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28841901/outcome-of-colon-cancer-initially-presenting-as-colon-perforation-and-obstruction
#16
Tsung-Ming Chen, Yen-Ta Huang, Guan-Chyuan Wang
BACKGROUND: Emergency complications of colon cancer include perforation and obstruction which were recognized as poor prognostic factors. Few studies have directly compared the outcomes of these two groups. In this study, we evaluated mortality and morbidity in patients with colon cancer initially presenting as perforation and obstruction. METHODS: Newly diagnosed colon cancer cases initially presenting with perforation or obstruction at Tzu Chi General Hospital, Hualien, Taiwan, between 2009 and 2015 were included...
August 25, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28841567/breaking-in-and-busting-out-cell-penetrating-peptides-and-the-endosomal-escape-problem
#17
REVIEW
Julia C LeCher, Scott J Nowak, Jonathan L McMurry
Cell-penetrating peptides (CPPs) have long held great promise for the manipulation of living cells for therapeutic and research purposes. They allow a wide array of biomolecules from large, oligomeric proteins to nucleic acids and small molecules to rapidly and efficiently traverse cytoplasmic membranes. With few exceptions, if a molecule can be associated with a CPP, it can be delivered into a cell. However, a growing realization in the field is that CPP-cargo fusions largely remain trapped in endosomes and are eventually targeted for degradation or recycling rather than released into the cytoplasm or trafficked to a desired subcellular destination...
September 26, 2017: Biomolecular Concepts
https://www.readbyqxmd.com/read/28836254/-usefulness-of-self-made-gasbag-double-cannula-stool-drainage-device-for-prevention-of-anastomotic-leakage-following-anterior-resection
#18
Donghui Zhang, Kui He, Huaiyu Qiu, Zhehong Zhuang, Yingcong Liufu, Jianbao Zhang, Xinchen Zeng
OBJECTIVE: To evaluate the efficacy of self-made gasbag double-cannula stool drainage device for prevention of anastomotic leakage following anterior resection. METHODS: Clinical data of 169 rectal cancer patients in the 8th Affiliated Hospital of Sun Yat-sen University between October 2010 and October 2016 were retrospectively analyzed. Among them, a self-made gasbag double-cannula stool drainage device was placed in 71 patients(stool drainage group), and the remaining 98 patients were taken as control...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28836251/-robotic-assisted-transanal-total-mesorectal-excision-for-lower-rectal-cancer
#19
Jingwang Ye, Yue Tian, Li Wang, Yong Ye, Yong Zhang, Fan Li, Baohua Liu, Weidong Tong
OBJECTIVE: To explore the availability of Da Vinci robotic-assisted transanal total mesorectal excision(taTME) for lower rectal cancer, which have been regarded as challenging situations in rectal cancer surgery. METHODS: The medical records of a patient who underwent robotic-assisted transanal total mesorectal excision, coloanal anastomosis and ileostomy for lower rectal cancer on May 31st 2017 were reported. RESULTS: The case was a sixty-three year-old male patient with a body mass index of 19...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28836243/-how-to-standardize-transanal-total-mesorectum-excision
#20
Liang Kang
Transanal total mesorectum excision (taTME) is a novel approach to treat rectal cancer by colorectal surgeons. How to standardize taTME is important for colorectal surgeons, especially at their initial attempt. They can start this approach cautiously only after they master skilled laparoscopic technique and pelvic anatomy, get the knowledge of taTME clearly, and are approved by healthcare department. The female patients with age <70 years old, distance of 5 to 7 cm from tumor inferior margin to anal verge, tumor size <3 cm, cTNM stage <T3aN0 are suitable for taTME...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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