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https://www.readbyqxmd.com/read/27865732/prevention-of-heartmate-ii-pump-thrombosis-through-clinical-management-the-prevent-multi-center-study
#1
Simon Maltais, Ahmet Kilic, Sriram Nathan, Mary Keebler, Sitaramesh Emani, John Ransom, Jason N Katz, Brett Sheridan, Andreas Brieke, Gregory Egnaczyk, John W Entwistle, Robert Adamson, John Stulak, Nir Uriel, John B O'Connell, David J Farrar, Kartik S Sundareswaran, Igor Gregoric
BACKGROUND: Recommended structured clinical practices including implant technique, anti-coagulation strategy, and pump speed management (PREVENT [PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management] recommendations) were developed to address risk of early (<3 months) pump thrombosis (PT) risk with HeartMate II (HMII; St. Jude Medical, Inc. [Thoratec Corporation], Pleasanton, CA). We prospectively assessed the HMII PT rate in the current era when participating centers adhered to the PREVENT recommendations...
November 16, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27865723/mechanisms-of-effort-intolerance-in-patients-with-rheumatic-mitral-stenosis-combined-echocardiography-and-cardiopulmonary-stress%C3%A2-protocol
#2
Michal Laufer-Perl, Yaniv Gura, Jason Shimiaie, Jack Sherez, Gregg S Pressman, Galit Aviram, Simon Maltais, Ricki Megidish, Amir Halkin, Meirav Ingbir, Simon Biner, Gad Keren, Yan Topilsky
OBJECTIVES: This study sought to evaluate mechanisms of effort intolerance in patients with rheumatic mitral stenosis (MS). BACKGROUND: Combined stress echocardiography and cardiopulmonary testing allows assessment of cardiac function, hemodynamics, and oxygen extraction (A-Vo2 difference). METHODS: Using semirecumbent bicycle exercise, 20 patients with rheumatic MS (valve area 1.36 ± 0.4 cm(2)) were compared to 20 control subjects at 4 pre-defined activity stages (rest, unloaded, anaerobic threshold, and peak)...
November 10, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27861566/findings-on-thoracic-computed-tomography-scans-and-respiratory-outcomes-in-persons-with-and-without-chronic-obstructive-pulmonary-disease-a-population-based-cohort-study
#3
Wan C Tan, Cameron J Hague, Jonathon Leipsic, Jean Bourbeau, Liyun Zheng, Pei Z Li, Don D Sin, Harvey O Coxson, Miranda Kirby, James C Hogg, Rekha Raju, Jeremy Road, Denis E O'Donnell, Francois Maltais, Paul Hernandez, Robert Cowie, Kenneth R Chapman, Darcy D Marciniuk, J Mark FitzGerald, Shawn D Aaron
BACKGROUND: Thoracic computed tomography (CT) scans are widely performed in clinical practice, often leading to detection of airway or parenchymal abnormalities in asymptomatic or minimally symptomatic individuals. However, clinical relevance of CT abnormalities is uncertain in the general population. METHODS: We evaluated data from 1361 participants aged ≥40 years from a Canadian prospective cohort comprising 408 healthy never-smokers, 502 healthy ever-smokers, and 451 individuals with spirometric evidence of chronic obstructive pulmonary disease (COPD) who had thoracic CT scans...
2016: PloS One
https://www.readbyqxmd.com/read/27859590/miz-1-and-max-compete-to-engage-c-myc-implication-for-the-mechanism-of-inhibition-of-c-myc-transcriptional-activity-by-miz-1
#4
Mikaël Bédard, Loïka Maltais, Martin Montagne, Pierre Lavigne
c-Myc is a basic Helix-Loop-Helix Leucine Zipper (b-HLH-LZ) transcription factor deregulated in the majority of human cancers. As a heterodimer with Max, another b-HLH-LZ transcription factor, deregulated and persistent c-Myc accumulates at transcriptionally active promoters and enhancers and amplifies transcription. This leads to the so-called transcriptional addiction of tumor cells. Recent studies have showed that the c-Myc transcriptional activities can be reversed by its association with Miz-1, a POZ transcription factor containing 13 classical zinc fingers...
November 16, 2016: Proteins
https://www.readbyqxmd.com/read/27834608/factors-associated-with-moderate-to-vigorous-physical-activity-in-adolescents-born-preterm
#5
Ketsia Proulx, Annette Majnemer, Noémi Dahan-Oliel, Barbara Mazer, Line Nadeau, Kathleen Vanier, Désirée B Maltais
PURPOSE: Little is known about the physical activity of adolescents born prematurely. This study aimed to: 1) describe relationships between moderate to vigorous physical activity (MVPA) in adolescents born prematurely and various factors and, 2) compare their MVPA level to guidelines. METHODS: A secondary analysis was performed using data from 64 adolescents (16.1 ± 2.5 years old, born ≤29 weeks gestation; 57.8% girls). Time spent in MVPA was based on accelerometry data...
November 11, 2016: Pediatric Exercise Science
https://www.readbyqxmd.com/read/27794080/automatic-oxygen-titration-during-walking-in-subjects-with-copd-a-randomized-crossover-controlled-study
#6
François Lellouche, Erwan L'Her, Pierre-Alexandre Bouchard, Cynthia Brouillard, François Maltais
BACKGROUND: Arterial oxygen desaturation frequently occurs in patients with COPD during daily activities at home. Oxygen flow is usually set at fixed and low rates for ambulatory patients. We evaluated an innovative closed-loop system (FreeO2) that automatically adjusts the oxygen flow to the patient's needs in subjects with COPD during walking followed by recovery time, such as during ambulatory conditions. METHODS: Patients with COPD who exhibited oxygen desaturation on exertion were included in the study...
November 2016: Respiratory Care
https://www.readbyqxmd.com/read/27793517/a-multi-institutional-outcome-analysis-of-patients-undergoing-left-ventricular-assist-device-implantation-stratified-by-sex-and-race
#7
Justin van Meeteren, Simon Maltais, Shannon M Dunlay, Nicholas A Haglund, Mary Beth Davis, Jennifer Cowger, Palak Shah, Keith D Aaronson, Francis D Pagani, John M Stulak
BACKGROUND: Earlier studies have demonstrated disparities in patients undergoing left ventricular assist device (LVAD) implantation when stratified according to sex and race. Because very few data exist from large investigations, we reviewed data from the registry of the Mechanical Circulatory Support Research Network. METHODS: Between May 2004 and September 2014, 734 patients underwent primary LVAD implantation at our institutions. Median age at implant was 57 (range 18 to 82) years and there were 577 males (80%)...
September 7, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27765670/ventricular-assist-device-therapy-in-older-patients-with-heart-failure-characteristics-and-outcomes
#8
Ju H Kim, Ramesh Singh, Francis D Pagani, Shashank S Desai, Nicholas A Haglund, Shannon M Dunlay, Simon Maltais, Keith D Aaronson, John M Stulak, Mary E Davis, Christopher T Salerno, Jennifer A Cowger, Palak Shah
BACKGROUND: Limited data exist on outcomes in patients ≥70 years of age supported with the use of continuous-flow left ventricular assist devices (LVADs). METHODS: Data on 1149 continuous-flow LVAD recipients was queried from the Mechanical Circulatory Support Research Network. Groups were assigned based on age: ≥70 years ("older patients") and <70 years. The primary outcome was survival at one-year based on age grouping. RESULTS: Compared with younger patients (54...
October 17, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27743635/correlation-of-pre-explant-lactate-dehydrogenase-concentrations-and-findings-during-post-explant-pump-analysis-of-the-heartmate-ii-left-ventricular-assist-device
#9
Vikram Sood, Osman Alam, Vakhtang Tchantchaleishvili, Francis D Pagani, Keith D Aaronson, Jonathan Haft, David L Joyce, Lyle D Joyce, Richard C Daly, Simon Maltais, John M Stulak
BACKGROUND: Analyses of the HeartMate II left ventricular assist device are routinely performed after explant if returned to the manufacturer. Findings from manufacturer-reported pump analyses have not been correlated with pre-explant serum lactate dehydrogenase (LDH) values. METHODS: Between May 2004 and December 2014, 502 patients underwent primary HeartMate II implantation. Seventy pumps were explanted in 58 patients and returned to the manufacturer for pump analysis: 51 (73%) for suspected pump thrombosis, 12 (17%) for device-related infection, and 7 (13%) for percutaneous lead fracture...
October 12, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27676938/factors-associated-with-the-physical-activity-of-adolescents-born-extremely-prematurely
#10
Désirée Maltais, Ketsia Proulx, Annette Majnemer, Noémi Dahan-Oliel, Barbara Mazer, Line Nadeau
OBJECTIVE: This study aimed to describe relationships between the time adolescents born extremely prematurely spend in moderate-to-vigorous physical activity (MVPA) and selected sociodemographic, prematurity and co-morbidity factors. MATERIAL/PATIENTS AND METHODS: Participants were 64 adolescents, 16.1±2.5years old (57.8% girls), who were born<30weeks gestation. They each wore an accelerometer over the right hip for up to seven days in order to establish their time spent in MVPA...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27632042/a-roundtable-discussion-exploring-major-trends-in-dialysis-practice-and-technology
#11
Sean Loughlin, Danilo Concepcion, Gema Gonzalez, Jo-Ann Maltais, Carolyn Neuland, Joseph Pulliam, Denny Treu, Richard J Williams
No abstract text is available yet for this article.
September 2016: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/27623610/the-effects-of-acute-intense-physical-exercise-on-postural-stability-in-children-with-cerebral-palsy
#12
Matthew J Leineweber, Dominik Wyss, Sophie-Krystale Dufour, Claire Gane, Karl Zabjek, Laurent J Bouyer, Désirée B Maltais, Julien I Voisin, Jan Andrysek
This study evaluated the effects of intense physical exercise on postural stability of children with cerebral palsy (CP). Center of pressure (CoP) was measured in 9 typically developing (TD) children and 8 with CP before and after a maximal aerobic shuttle-run test (SRT) using a single force plate. Anteroposterior and mediolateral sway velocities, sway area, and sway regularity were calculated from the CoP data and compared between pre- and postexercise levels and between groups. Children with CP demonstrated significantly higher pre-SRT CoP velocities than TD children in the sagittal (18...
July 2016: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/27601891/automated-oxygen-titration-and-weaning-with-freeo2-in-patients-with-acute-exacerbation-of-copd-a-pilot-randomized-trial
#13
François Lellouche, Pierre-Alexandre Bouchard, Maude Roberge, Serge Simard, Erwan L'Her, François Maltais, Yves Lacasse
INTRODUCTION: We developed a device (FreeO2) that automatically adjusts the oxygen flow rates based on patients' needs, in order to limit hyperoxia and hypoxemia and to automatically wean them from oxygen. OBJECTIVE: The aim of this study was to evaluate the feasibility of using FreeO2 in patients hospitalized in the respiratory ward for an acute exacerbation of COPD. METHODS: We conducted a randomized controlled trial comparing FreeO2 vs manual oxygen titration in the respiratory ward of a university hospital...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27594052/comparison-of-techniques-for-culture-of-dialysis-water-and-fluid
#14
Jo-Ann B Maltais, Klemens B Meyer, Meredith C Foster
Introduction Microbiological culture of dialysis water and fluid is a routine safety measure. In the United States (U.S.), laboratories perform these cultures on trypticase soy agar at 35-37°C for 48 h (TSA-48h), not on the tryptone glucose extract agar or Reasoner's 2A agar at 17-23°C for 7 days (TGEA-7d and R2A-7d, respectively) recommended by international standards. We compared culture methods to identify samples exceeding the accepted action level of 50 CFU/mL. Methods Dialysis water and fluid samples collected from 41 U...
September 5, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27577033/outcomes-of-patients-receiving-temporary-circulatory-support-before-durable-ventricular-assist-device
#15
Palak Shah, Francis D Pagani, Shashank S Desai, Anthony J Rongione, Simon Maltais, Nicholas A Haglund, Shannon M Dunlay, Keith D Aaronson, John M Stulak, Mary Beth Davis, Christopher T Salerno, Jennifer A Cowger
BACKGROUND: Temporary circulatory support (TCS) is used to stabilize patients in critical cardiogenic shock and bridge patients to a durable ventricular assist device (VAD). Whether TCS confers increased risk at the time of VAD implant is unknown. METHODS: Prospectively collected data from five institutions was retrospectively reviewed. All profile 1 through profile 3 patients implanted with a continuous-flow VAD (n = 804) were categorized into three groups: TCS (n = 68); non-TCS profile 1 (n = 70); and non-TCS profile 2-3 (n = 666)...
August 28, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27562568/sex-specific-association-between-obesity-and-self-reported-falls-and-injuries-among-community-dwelling-canadians-aged-65%C3%A2-years-and-older
#16
G A Handrigan, N Maltais, M Gagné, P Lamontagne, D Hamel, N Teasdale, O Hue, P Corbeil, J P Brown, S Jean
: This study investigated the relationship between body mass index (BMI) and falls among community-dwelling elderly. Results indicate that obesity is associated with increased falls and there appears to be a sex-specific difference with obese men at higher risk of falling. Obesity is identified as a risk factor for falls in men. INTRODUCTION: The prevalence of falls, fall-related injuries, and obesity has increased over the last decade. The objectives of this study were to investigate sex-specific association and dose-response relationship between BMI and falls (and related injuries) among community-dwelling elderly...
August 25, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27556153/active-clearance-of-chest-tubes-reduces-re-exploration-for-bleeding-after-ventricular-assist-device-implantation
#17
Simon Maltais, Mary E Davis, Nicholas A Haglund, Louis Perrault, Sudhir S Kushwaha, John M Stulak, Edward M Boyle
Chest tubes are utilized to evacuate shed blood after left ventricular assist device (LVAD) implantation, however, they can become clogged, leading to retained blood. We implemented a protocol for active tube clearance (ATC) of chest tubes to determine if this might reduce interventions for retained blood. A total of 252 patients underwent LVAD implantation. Seventy-seven patients had conventional chest tube drainage (group 1), whereas 175 patients had ATC (group 2). A univariate and multivariate analysis adjusting for the use of conventional sternotomy (CS) and minimally invasive left thoracotomy (MILT) was performed...
November 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27553727/explorative-study-on-the-anticancer-activity-selectivity-and-metabolic-stability-of-related-analogs-of-aminosteroid-rm-133
#18
Martin Perreault, René Maltais, Raphaël Dutour, Donald Poirier
RM-133 is a key representative of a new family of aminosteroids reported as potent anticancer agents. Although RM-133 produced interesting results in 4 mouse xenograft cancer models when injected subcutaneously, it needs to be improved to increase its in vivo potency. Thus, to obtain an analog of RM-133 with a better drug potential, a structure-activity relationship study was conducted by synthesizing eleven RM-133-related compounds and addressing their antiproliferative activity on 3 human cancer cells (HL-60, OVCAR-3 and PANC-1) and 3 human normal cell lines (primary ovary, pancreas and renal proximal tubule) as well as their metabolic stability in human liver microsomes...
November 2016: Steroids
https://www.readbyqxmd.com/read/27522458/adaptations-in-limb-muscle-function-following-pulmonary-rehabilitation-in-patients-with-copd-a-review
#19
André Nyberg, João Carvalho, Kim-Ly Bui, Didier Saey, François Maltais
Even though chronic obstructive pulmonary disease (COPD) is primarily a disease of the respiratory system, limb muscle dysfunction characterized by muscle weakness, reduced muscle endurance and higher muscle fatigability, is a common secondary consequence and a major systemic manifestation of the disease. Muscle dysfunction is especially relevant in COPD because it is related to important clinical outcomes such as mortality, quality of life and exercise intolerance, independently of lung function impairment...
August 10, 2016: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/27383762/evaluation-of-the-effects-of-olodaterol-on-exercise-endurance-in-patients-with-chronic-obstructive-pulmonary-disease-results-from-two-6-week-crossover-studies
#20
François Maltais, Anne-Marie Kirsten, Alan Hamilton, Dorothy De Sousa, Florian Voß, Marc Decramer
BACKGROUND: Two replicate, double-blind, placebo-controlled, 6-week crossover studies assessed the effect of the once-daily long-acting β2-agonist olodaterol 5 μg and 10 μg on constant work-rate cycle endurance in patients with moderate to very severe chronic obstructive pulmonary disease. METHODS: Patients received placebo, olodaterol 5 μg once daily (QD) and olodaterol 10 μg QD in a randomised order for 6 weeks each, with a 2-week washout period in between...
2016: Respiratory Research
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