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https://www.readbyqxmd.com/read/29664681/effect-of-bronchodilation-and-exercise-training-with-behavior-modification-on-exercise-tolerance-and-downstream-effects-on-symptoms-and-physical-activity-in-copd
#1
Thierry Troosters, François Maltais, Nancy Leidy, Kim L Lavoie, Maria Sedeno, Wim Janssens, Judith Garcia-Aymerich, Damijan Erzen, Dorothy De Sousa, Lawrence Korducki, Alan Hamilton, Jean Bourbeau
RATIONALE: Bronchodilation and exercise training (ExT) improve exercise tolerance in patients with chronic obstructive pulmonary disease (COPD); however, behavior modification is required to impact on daily physical activity (PA). OBJECTIVES: To assess whether tiotropium/olodaterol, ±ExT, would improve exercise endurance time (EET) and PA compared with placebo in patients participating in a self-management behavior-modification (SMBM) program. METHODS: A 12-week, randomized, partially double-blind, placebo-controlled, parallel-group trial in patients with COPD (PHYSACTO®; NCT02085161)...
April 17, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29656048/trunk-muscle-quality-assessed-by-computed-tomography-association-with-adiposity-indices-and-glucose-tolerance-in-men
#2
Alexandre Maltais, Natalie Alméras, Isabelle Lemieux, Angelo Tremblay, Jean Bergeron, Paul Poirier, Jean-Pierre Després
BACKGROUND/OBJECTIVES: Thigh muscle attenuation measured by computed tomography (CT) has been shown to be a reliable and useful index of skeletal muscle fat infiltration. Thigh muscle fat content assessed by CT has been linked to obesity and type 2 diabetes and is a correlate of insulin resistance in sedentary individuals. However, as measurement of mid-thigh fat content requires the assessment of another region of interest beyond the usual abdominal scan required to measure levels of visceral and subcutaneous abdominal adipose tissue, this study aimed at testing the hypothesis that skeletal muscle fat measured from a single abdominal scan (L4 -L5 ) would also provide information relevant to the estimation of muscle fat infiltration as it relates to cardiometabolic risk...
April 12, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29579057/exacerbation-induces-a-microbiota-shift-in-sputa-of-copd-patients
#3
Eric Jubinville, Marc Veillette, Julie Milot, François Maltais, André M Comeau, Roger C Levesque, Caroline Duchaine
Little is known about the microbiota shift induced by exacerbation in chronic obstructive pulmonary disease (COPD) patients. The sputa microbiota of COPD patients was evaluated when clinically stable and during acute exacerbations of the disease. Sputa microbiota was analyzed using 16S ribosomal RNA gene pyrosequencing and quantitative polymerase chain reaction-based pathogen detection. Nine COPD patients were enrolled. Pyrosequencing of 16S rRNA genes identified 2,267 unique bacterial operational taxonomic units...
2018: PloS One
https://www.readbyqxmd.com/read/29567380/in-people-with-chronic-obstructive-pulmonary-disease-home-based-pulmonary-rehabilitation-produces-similar-results-to-a-hospital-based-outpatient-program-commentary
#4
https://www.readbyqxmd.com/read/29559262/integration-of-simulation-components-enhances-team-training-in-cardiac-surgery
#5
David L Joyce, Brian D Lahr, Simon Maltais, Sameh M Said, John M Stulak, Gregory A Nuttall, Lyle D Joyce
OBJECTIVES: Simulation in resident medical education has traditionally focused on isolated components of a surgical procedure. We hypothesized that incorporating an interdisciplinary team into a high-fidelity simulation laboratory would enhance the modeling of real-world challenges during cardiac surgery. METHODS: Simulation exercises were performed with staffing by surgeons, anesthesiologists, perfusionists, surgical assistants, and operating room technicians. Twelve accredited cardiothoracic surgical residents were divided into 3 teams...
February 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29551541/current-trends-in-bilateral-internal-thoracic-artery-use-for-coronary-revascularization-extending-benefit-to-high-risk-patients
#6
Nishant Saran, Chaim Locker, Sameh M Said, Richard C Daly, Simon Maltais, John M Stulak, Kevin L Greason, Alberto Pochettino, Hartzell V Schaff, Joseph A Dearani, Lyle D Joyce, Brian D Lahr, David L Joyce
BACKGROUND: We sought to identify the trends in bilateral internal thoracic artery use and determine the degree to which the survival advantage of bilateral internal thoracic artery revascularization persists among perceived "high-risk" patients, compared with the use of left internal thoracic artery alone. METHODS: A retrospective review was conducted of patients who underwent isolated coronary artery bypass grafting for multivessel coronary artery disease at the Mayo Clinic between January 2000 and December 2015...
February 23, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29547003/home-oxygen-in-chronic-obstructive-pulmonary-disease
#7
Yves Lacasse, Ai-Yui M Tan, François Maltais, Jerry A Krishnan
Two landmark trials conducted more than 35 years ago provided scientific evidence that, under very specific circumstances, long-term oxygen therapy (LTOT) may prolong life. These two trials enrolled 290 patients with chronic obstructive pulmonary disease (COPD) and severe daytime hypoxemia documented by direct arterial blood gas measurement. From this moment, LTOT became a standard of care and the indications for oxygen therapy have expanded to include nocturnal oxygen therapy for isolated nocturnal oxygen desaturation, ambulatory oxygen to correct exercise-induced desaturation, and short-burst oxygen to relieve dyspnea...
March 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29538016/noninvasive-blood-pressure-monitor-designed-for-patients-with-heart-failure-supported-with-continuous-flow-left-ventricular-assist-devices
#8
Pavol Sajgalik, Vaclav Kremen, Vratislav Fabian, Simon Maltais, John M Stulak, Sudhir S Kushwaha, Lyle D Joyce, John A Schirger, Bruce D Johnson
The gold standard for noninvasive blood pressure (BP) measurement, the Doppler technique, does not provide systolic blood pressure (SBP) and diastolic blood pressure (DBP) and may limit therapy outcomes. To improve patient care, we tested specifically designed experimental BP (ExpBP) monitor and the Doppler technique by comparing noninvasive measures to the intraarterial (I-A) BP in 31 patients with end-stage heart failure (4 females) 2.6 ± 3.4 days post-LVAD implantation (20 HeartMate II and 11 HeartWare)...
March 13, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29521249/parallel-solid-phase-synthesis-using-a-new-diethylsilylacetylenic-linker-and-leading-to-mestranol-derivatives-with-potent-antiproliferative-activities-on-multiple-cancer-cell-lines
#9
Raphael Dutour, Rene Maltais, Martin Perreault, Jenny Roy, Donald Poirier
RM-133 belongs to a new family of aminosteroid derivatives demonstrating interesting anticancer properties, as confirmed in vivo in four mouse cancer xenograft models. However, the metabolic stability of RM-133 needs to be improved. After investigation, the replacement of its androstane scaffold by a more stable estrane scaffold led to the development of the mestranol derivative RM-581. Using solid-phase strategy involving five steps, we quickly synthesized a series of RM-581 analogs using the recently-developed diethylsilyl acetylenic linker...
March 7, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29463621/ventilatory-support-or-respiratory-muscle-training-as-adjuncts-to-exercise-in-obese-cpap-treated-patients-with-obstructive-sleep-apnoea-a-randomised-controlled-trial
#10
Isabelle Vivodtzev, Renaud Tamisier, Marilie Croteau, Jean-Christian Borel, Angélique Grangier, Bernard Wuyam, Patrick Lévy, Caroline Minville, Frédéric Sériès, François Maltais, Jean-Louis Pépin
BACKGROUND: Obstructive sleep apnoea (OSA) and obesity are interdependent chronic diseases sharing reduced exercise tolerance and high cardiovascular risk. INTERVENTION: A 3-month intervention with innovative training modalities would further improve functional capacity and cardiovascular health than usual cycle exercise training in already continuous positive airway pressure (CPAP)-treated obese patients with OSA. METHODS: Fifty three patients (35<body mass index (BMI) <45 kg/m2 ) were randomly allocated to exercise training on a cycle ergometer, either alone (ERGO) or with respiratory muscle training (ERGO+RMT) or non-invasive ventilation (ERGO+NIV)...
February 20, 2018: Thorax
https://www.readbyqxmd.com/read/29454078/looking-for-capacities-rather-than-vulnerabilities-the-moderating-effect-of-health-assets-on-the-associations-between-adverse-social-position-and-health
#11
Mathieu Roy, Mélanie Levasseur, Isabelle Doré, France St-Hilaire, Bernard Michallet, Yves Couturier, Danielle Maltais, Bengt Lindström, Mélissa Généreux
To increase capacities and control over health, it is necessary to foster assets (i.e. factors enhancing abilities of individuals or communities). Acting as a buffer, assets build foundations for overcoming adverse conditions and improving health. However, little is known about the distribution of assets and their associations with social position and health. In this study, we documented the distribution of health assets and examined whether these assets moderate associations between adverse social position and self-reported health...
February 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29439648/effect-of-12-weeks-of-once-daily-tiotropium-olodaterol-on-exercise-endurance-during-constant-work-rate-cycling-and-endurance-shuttle-walking-in-chronic-obstructive-pulmonary-disease
#12
François Maltais, Denis O'Donnell, Juan Bautista Gáldiz Iturri, Anne-Marie Kirsten, Dave Singh, Alan Hamilton, Kay Tetzlaff, Yihua Zhao, Richard Casaburi
BACKGROUND: The TORRACTO® study evaluated the effects of tiotropium/olodaterol versus placebo on endurance time during constant work-rate cycling and constant speed shuttle walking in patients with chronic obstructive pulmonary disease (COPD) after 12 weeks of treatment. METHODS: The effects of once-daily tiotropium/olodaterol (2.5/5 and 5/5 μg) on endurance time during constant work-rate cycle ergometry (CWRCE) after 6 and 12 weeks of treatment were compared with placebo in patients with COPD in a randomized, double-blind, placebo-controlled, parallel-group clinical trial...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29438808/effect-of-tiotropium-on-spontaneous-expiratory-flow-volume-curves-during-exercise-in-gold-1-2-copd
#13
Janos Porszasz, Nicolò Carraro, Robert Cao, Ashwani Gore, Shuyi Ma, Thomas Jiang, François Maltais, Gary T Ferguson, Denis E O'Donnell, Asif Shaikh, Harry B Rossiter, Richard Casaburi
This substudy of a large, randomized, controlled trial (NCT01072396) examined tiotropium (18 μg qd) effects on dynamic hyperinflation during constant work rate treadmill exercise. Areas-under-the-spontaneous expiratory flow-volume (SEFV)-curves were compared in 20 COPD patients and 16 age-matched untreated controls, using rectangular area ratio (RAR) between peak intrabreath and end-expiratory flow. Seven patients exhibited SEFV curve concavity with RAR ≤ 0.5 (RAR low ) in ≥1 test without tiotropium; (mean ± SD FEV 1 : 1...
February 10, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29420960/long-term-sirolimus-for-primary-immunosuppression-in-heart-transplant-recipients
#14
Rabea Asleh, Alexandros Briasoulis, Walter K Kremers, Rosalyn Adigun, Barry A Boilson, Naveen L Pereira, Brooks S Edwards, Alfredo L Clavell, John A Schirger, Richard J Rodeheffer, Robert P Frantz, Lyle D Joyce, Simon Maltais, John M Stulak, Richard C Daly, Jonella Tilford, Woong-Gil Choi, Amir Lerman, Sudhir S Kushwaha
BACKGROUND: Small studies have reported superiority of sirolimus (SRL) over calcineurin inhibitor (CNI) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). However, data on the long-term effect on CAV progression and clinical outcomes are lacking. OBJECTIVES: The aim of this study was to test the long-term safety and efficacy of conversion from CNI to SRL as maintenance therapy on CAV progression and outcomes after HT. METHODS: A cohort of 402 patients who underwent HT and were either treated with CNI alone (n = 134) or converted from CNI to SRL (n = 268) as primary immunosuppression was analyzed...
February 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29409618/outcome-of-tricuspid-valve-surgery-in-the-presence-of-permanent-pacemaker
#15
Nishant Saran, Sameh M Said, Hartzell V Schaff, Simon Maltais, John M Stulak, Kevin L Greason, Richard C Daly, Alberto Pochettino, Katherine S King, Joseph A Dearani
OBJECTIVES: Given the paucity of available literature, we sought to evaluate the mechanisms of tricuspid regurgitation and the outcomes of tricuspid valve surgery in the presence of permanent pacemakers. METHODS: We retrospectively reviewed the records of 622 adult patients who underwent tricuspid valve surgery in the presence of permanent pacemakers between January 1993 and December 2013. Those with prosthetic tricuspid valve or tricuspid valve endocarditis and those undergoing concomitant heart transplant were excluded (n = 23)...
April 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29386889/relationship-between-exercise-endurance-and-static-hyperinflation-in-a-post-hoc-analysis-of-two-clinical-trials-in-patients-with-copd
#16
Sally Singh, François Maltais, Lee Tombs, William A Fahy, Mitra Vahdati-Bolouri, Nicholas Locantore, John H Riley
Background: Lung hyperinflation and exercise intolerance are hallmarks of chronic obstructive pulmonary disease (COPD). However, their relationship remains uncertain. A combined analysis of two placebo-controlled, randomized studies examined the effects of the long-acting muscarinic antagonist umeclidinium (UMEC) and long-acting β2 -agonist vilanterol (VI) separately and in combination on static hyperinflation, exercise endurance time (EET), and their relationship in patients with COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29362258/cost-effectiveness-of-freeo-2-in-patients-with-chronic-obstructive-pulmonary-disease-hospitalised-for-acute-exacerbations-analysis-of-a-pilot-study-in-quebec
#17
Thomas G Poder, Christian R C Kouakou, Pierre-Alexandre Bouchard, Véronique Tremblay, Sébastien Blais, François Maltais, François Lellouche
OBJECTIVE: Conduct a cost-effectiveness analysis of FreeO2 technology versus manual oxygen-titration technology for patients with chronic obstructive pulmonary disease (COPD) hospitalised for acute exacerbations. SETTING: Tertiary acute care hospital in Quebec, Canada. PARTICIPANTS: 47 patients with COPD hospitalised for acute exacerbations. INTERVENTION: An automated oxygen-titration and oxygen-weaning technology. METHODS AND OUTCOMES: The costs for hospitalisation and follow-up for 180 days were calculated using a microcosting approach and included the cost of FreeO2 technology...
January 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29357500/cardiorespiratory-and-muscle-oxygenation-responses-to-low-load-high-repetition-resistance-exercises-in-copd-and-healthy-controls
#18
André Nyberg, Didier Saey, Mickaël Martin, François Maltais
Single-limb exercises have been used as a strategy to improve aerobic exercise tolerance in patients with chronic obstructive pulmonary disease (COPD) by alleviating the cardiopulmonary demand. We asked whether this strategy would also apply to cardiorespiratory demand and amount of work performed during single-limb and two-limb low-load/high-repetition resistance exercises in 20 patients with COPD [forced expiratory volume in 1 s (FEV1 ) = 1.0 liters, 38% of predicted] and 15 age-, sex-, and activity-matched healthy controls...
April 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29355547/%C3%AE-blockers-in-copd-a-cohort-study-from-the-tonado-research-program
#19
François Maltais, Roland Buhl, Andrea Koch, Valeria C Amatto, Jim Reid, Lars Grönke, Ulrich Bothner, Florian Voß, Lorcan McGarvey, Gary T Ferguson
BACKGROUND: Cardiovascular disease is a frequent comorbidity in patients with COPD. Many physicians, particularly pulmonologists, are reluctant to use β-adrenoceptor blocking agents (β-blockers) in patients with COPD, despite their proven effectiveness in preventing cardiovascular events. METHODS: The large (5,162 patients) phase III TONADO 1 and 2 studies assessed lung function and patient-reported outcomes in patients with moderate to very severe COPD receiving long-acting bronchodilator treatment across 1 year...
January 31, 2018: Chest
https://www.readbyqxmd.com/read/29287690/implication-of-stard5-and-cholesterol-homeostasis-disturbance-in-the-endoplasmic-reticulum-stress-related-response-induced-by-pro-apoptotic-aminosteroid-rm-133
#20
Martin Perreault, René Maltais, Lucie Carolle Kenmogne, Danny Létourneau, Jean-Guy LeHoux, Stéphane Gobeil, Donald Poirier
The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties of the representative candidate RM-133 needs to be characterized. In vitro experiments were first used to determine that RM-133 causes apoptosis in cancer cells. Then, using proteomic and transcriptomic experiments, RM-133 cytotoxicity was proven to be achieved via the endoplasmic reticulum (ER)-related apoptosis, which characterizes RM-133 as an endoplasmic reticulum stress aggravator (ERSA) anticancer drug...
February 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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