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https://www.readbyqxmd.com/read/29454078/looking-for-capacities-rather-than-vulnerabilities-the-moderating-effect-of-health-assets-on-the-associations-between-adverse-social-position-and-health
#1
Mathieu Roy, Mélanie Levasseur, Isabelle Doré, France St-Hilaire, Bernard Michallet, Yves Couturier, Danielle Maltais, Bengt Lindström, Mélissa Généreux
To increase capacities and control over health, it is necessary to foster assets (i.e. factors enhancing abilities of individuals or communities). Acting as a buffer, assets build foundations for overcoming adverse conditions and improving health. However, little is known about the distribution of assets and their associations with social position and health. In this study, we documented the distribution of health assets and examined whether these assets moderate associations between adverse social position and self-reported health...
February 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29439648/effect-of-12-weeks-of-once-daily-tiotropium-olodaterol-on-exercise-endurance-during-constant-work-rate-cycling-and-endurance-shuttle-walking-in-chronic-obstructive-pulmonary-disease
#2
François Maltais, Denis O'Donnell, Juan Bautista Gáldiz Iturri, Anne-Marie Kirsten, Dave Singh, Alan Hamilton, Kay Tetzlaff, Yihua Zhao, Richard Casaburi
BACKGROUND: The TORRACTO ® study evaluated the effects of tiotropium/olodaterol versus placebo on endurance time during constant work-rate cycling and constant speed shuttle walking in patients with chronic obstructive pulmonary disease (COPD) after 12 weeks of treatment. METHODS: The effects of once-daily tiotropium/olodaterol (2.5/5 and 5/5 μg) on endurance time during constant work-rate cycle ergometry (CWRCE) after 6 and 12 weeks of treatment were compared with placebo in patients with COPD in a randomized, double-blind, placebo-controlled, parallel-group clinical trial...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29438808/effect-of-tiotropium-on-spontaneous-expiratory-flow-volume-curves-during-exercise-in-gold-1-2-copd
#3
Janos Porszasz, Nicolò Carraro, Robert Cao, Ashwani Gore, Shuyi Ma, Thomas Jiang, François Maltais, Gary T Ferguson, Denis E O'Donnell, Asif Shaikh, Harry B Rossiter, Richard Casaburi
This substudy of a large, randomized, controlled trial (NCT01072396) examined tiotropium (18 μg qd) effects on dynamic hyperinflation during constant work rate treadmill exercise. Areas-under-the-spontaneous expiratory flow-volume (SEFV)-curves were compared in 20 COPD patients and 16 age-matched untreated controls, using rectangular area ratio (RAR) between peak intrabreath and end-expiratory flow. Seven patients exhibited SEFV curve concavity with RAR ≤ 0.5 (RAR low ) in ≥1 test without tiotropium; (mean ± SD FEV 1 : 1...
February 10, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29420960/long-term-sirolimus-for-primary-immunosuppression-in-heart-transplant-recipients
#4
Rabea Asleh, Alexandros Briasoulis, Walter K Kremers, Rosalyn Adigun, Barry A Boilson, Naveen L Pereira, Brooks S Edwards, Alfredo L Clavell, John A Schirger, Richard J Rodeheffer, Robert P Frantz, Lyle D Joyce, Simon Maltais, John M Stulak, Richard C Daly, Jonella Tilford, Woong-Gil Choi, Amir Lerman, Sudhir S Kushwaha
BACKGROUND: Small studies have reported superiority of sirolimus (SRL) over calcineurin inhibitor (CNI) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). However, data on the long-term effect on CAV progression and clinical outcomes are lacking. OBJECTIVES: The aim of this study was to test the long-term safety and efficacy of conversion from CNI to SRL as maintenance therapy on CAV progression and outcomes after HT. METHODS: A cohort of 402 patients who underwent HT and were either treated with CNI alone (n = 134) or converted from CNI to SRL (n = 268) as primary immunosuppression was analyzed...
February 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29409618/outcome-of-tricuspid-valve-surgery-in-the-presence-of-permanent-pacemaker
#5
Nishant Saran, Sameh M Said, Hartzell V Schaff, Simon Maltais, John M Stulak, Kevin L Greason, Richard C Daly, Alberto Pochettino, Katherine S King, Joseph A Dearani
OBJECTIVES: Given the paucity of available literature, we sought to evaluate the mechanisms of tricuspid regurgitation and the outcomes of tricuspid valve surgery in the presence of permanent pacemakers. METHODS: We retrospectively reviewed the records of 622 adult patients who underwent tricuspid valve surgery in the presence of permanent pacemakers between January 1993 and December 2013. Those with prosthetic tricuspid valve or tricuspid valve endocarditis and those undergoing concomitant heart transplant were excluded (n = 23)...
December 19, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29386889/relationship-between-exercise-endurance-and-static-hyperinflation-in-a-post-hoc-analysis-of-two-clinical-trials-in-patients-with-copd
#6
Sally Singh, François Maltais, Lee Tombs, William A Fahy, Mitra Vahdati-Bolouri, Nicholas Locantore, John H Riley
Background: Lung hyperinflation and exercise intolerance are hallmarks of chronic obstructive pulmonary disease (COPD). However, their relationship remains uncertain. A combined analysis of two placebo-controlled, randomized studies examined the effects of the long-acting muscarinic antagonist umeclidinium (UMEC) and long-acting β2-agonist vilanterol (VI) separately and in combination on static hyperinflation, exercise endurance time (EET), and their relationship in patients with COPD...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29362258/cost-effectiveness-of-freeo2-in-patients-with-chronic-obstructive-pulmonary-disease-hospitalised-for-acute-exacerbations-analysis-of-a-pilot-study-in-quebec
#7
Thomas G Poder, Christian R C Kouakou, Pierre-Alexandre Bouchard, Véronique Tremblay, Sébastien Blais, François Maltais, François Lellouche
OBJECTIVE: Conduct a cost-effectiveness analysis of FreeO2 technology versus manual oxygen-titration technology for patients with chronic obstructive pulmonary disease (COPD) hospitalised for acute exacerbations. SETTING: Tertiary acute care hospital in Quebec, Canada. PARTICIPANTS: 47 patients with COPD hospitalised for acute exacerbations. INTERVENTION: An automated oxygen-titration and oxygen-weaning technology. METHODS AND OUTCOMES: The costs for hospitalisation and follow-up for 180 days were calculated using a microcosting approach and included the cost of FreeO2 technology...
January 23, 2018: BMJ Open
https://www.readbyqxmd.com/read/29357500/cardiorespiratory-and-muscle-oxygenation-responses-to-low-load-high-repetitive-resistance-exercises-in-copd-and-healthy-controls
#8
Andre Nyberg, Didier Saey, Mickael Martin, François Maltais
Single-limb exercises have been used as a strategy to improve aerobic exercise tolerance in patients with COPD by alleviating the cardiopulmonary demand. We asked if this strategy would also apply to cardiorespiratory demand and amount of work performed during single-limb and two-limb low-load/high-repetition shoulder-flexion and knee-extension resistance exercises in 20 COPD patients (FEV1 = 1.0 L, 38% of predicted) and 15 matched controls. Peak ventilation (V̇E), peak oxygen consumption (V̇O2), peak heart rate (HR) and the total amount of work achieved were assessed...
December 21, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29355547/%C3%AE-blockers-in-chronic-obstructive-pulmonary-disease-a-cohort-study-from-the-tonado%C3%A2-research-programme
#9
François Maltais, Roland Buhl, Andrea Koch, Valeria C Amatto, Jim Reid, Lars Grönke, Ulrich Bothner, Florian Voß, Lorcan McGarvey, Gary T Ferguson
BACKGROUND: Cardiovascular disease is a frequent co-morbidity in patients with chronic obstructive pulmonary disease (COPD). Many clinicians, particularly pulmonologists, are reluctant to use β-adrenoceptor blocking agents (β-blockers) in patients with COPD, despite their proven effectiveness in preventing cardiovascular events. METHODS: The large (5,162 patients) phase III TONADO® 1 and 2 studies assessed lung function and patient-reported outcomes (PROs) in patients with moderate to very severe COPD receiving long-acting bronchodilator treatment over 1 year...
January 16, 2018: Chest
https://www.readbyqxmd.com/read/29287690/implication-of-stard5-and-cholesterol-homeostasis-disturbance-in-the-endoplasmic-reticulum-stress-related-response-induced-by-pro-apoptotic-aminosteroid-rm-133
#10
Martin Perreault, René Maltais, Lucie-Carole Kenmogne, Danny Létourneau, Jean-Guy LeHoux, Stéphane Gobeil, Donald Poirier
The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties of the representative candidate RM-133 needs to be characterized. In vitro experiments were first used to determine that RM-133 causes apoptosis in cancer cells. Then, using proteomic and transcriptomic experiments, RM-133 cytotoxicity was proven to be achieved via the endoplasmic reticulum (ER)-related apoptosis, which characterizes RM-133 as an endoplasmic reticulum stress aggravator (ERSA) anticancer drug...
December 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29260401/the-impact-of-post-resistance-exercise-protein-consumption-on-subsequent-appetite-and-daily-energy-intake-of-sarcopenic-older-men-a-pilot-study
#11
Mathieu Maltais, Morgane Du Bois-Dit-Bonclaude, Taha Amamou, Eléonor Riesco, Isabelle J Dionne
BACKGROUND: Because of its satiating effect, it has been widely purported that a high-protein beverage may reduce subsequent appetite and food intake in healthy aged individuals, therefore annihilating any supplemental effect. AIMS: The goal of the study was to examine the impact of a post-exercise protein supplement from dairy products in the hours following resistance exercise on subsequent energy intake, sensation of hunger, appetite and satiety in sarcopenic older men...
December 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29248731/pharmacokinetic-profile-of-pbrm-in-rodents-a-first-selective-covalent-inhibitor-of-17%C3%AE-hsd1-for-breast-cancer-and-endometriosis-treatments
#12
René Maltais, Alexandre Trottier, Jenny Roy, Diana Ayan, Nicolas Bertrand, Donald Poirier
The development of a covalent inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a promising approach for the treatment of hormone-dependent breast cancer and endometriosis. After reporting the steroid derivative PBRM as a first potent covalent inhibitor of 17β-HSD1 without estrogenic activity, we are now interested in studying its pharmaceutical behavior. The metabolism study in a human liver microsomal preparation showed a gradual transformation of PBRM into PBRM-O, an oxidized ketonic form of PBRM at position C17...
December 14, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29215969/protection-from-wintertime-rainfall-reduces-nutrient-losses-and-greenhouse-gas-emissions-during-the-decomposition-of-poultry-and-horse-manure-based-amendments
#13
Gabriel Maltais-Landry, Katarina Neufeld, David Poon, Nicholas Grant, Zoran Nesic, Sean Smukler
Manure-based soil amendments (herein "amendments") are important fertility sources but differences among amendment types and management can significantly affect their nutrient value and environmental impacts. We conducted a six-month in situ decomposition experiment to determine how protection from wintertime rainfall affected nutrient losses and greenhouse gas (GHG) emissions in poultry (chicken broiler and turkey) and horse amendments. We measured changes in total nutrient concentration - nitrogen (N), phosphorus (P), and potassium (K) - every three months, changes in ammonium (NH4+) and nitrate (NO3-) concentration every month, and GHG emissions of carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) every 7-14 days...
December 7, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29212567/the-quebec-emergency-department-guide-a-cross-sectional-study-to-evaluate-its-use-perceived-usefulness-and-implementation-in-rural-emergency-departments
#14
Richard Fleet, Sandrine Hegg-Deloye, Julie Maltais-Giguère, France Légaré, Mathieu Ouimet, Julien Poitras, Alain Tanguay, Patrick Archambault, Jean-Frédéric Levesque, Geneviève Simard-Racine, Gilles Dupuis
OBJECTIVES: The Quebec Emergency Department Management Guide (QEDMG) is a unique document with 78 recommendations designed to improve the organization of emergency departments (EDs) in the province of Quebec. However, no study has examined how this guide is perceived or used by rural health care management. METHODS: We invited all directors of professional services (DPS), directors of nursing services (DNS), head nurses (HN), and emergency department directors (EDD) working in Quebec's rural hospitals to complete an online survey (144 questions)...
December 7, 2017: CJEM
https://www.readbyqxmd.com/read/29182883/clinical-experience-with-serpina1-dna-sequencing-to-detect-alpha-1-antitrypsin-deficiency
#15
François Maltais, Nathalie Gaudreault, Christine Racine, Sébastien Thériault, Yohan Bossé
No abstract text is available yet for this article.
November 28, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29162536/functional-mitral-regurgitation-imaging-insights-clinical-outcomes-and-surgical-principles
#16
REVIEW
Nozomi Watanabe, Simon Maltais, Shun Nishino, Tara A O'Donoghue, Judy Hung
Functional mitral regurgitation (MR; FMR) is the most common type of MR and its development is associated with increased morbidity and mortality. Leaflet tethering with apical shift of the papillary muscle due to adverse left ventricular remodeling and loss of normal leaflet coaptation is the principal mechanism of FMR. Echocardiography plays a central role in the assessment of the FMR. The development of 3D echocardiography has allowed for assessment of the geometric changes of mitral valve morphology and spatial relationship with the left ventricle that accompanies FMR...
November 21, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29153636/early-intervention-for-lactate-dehydrogenase-elevation-improves-clinical-outcomes-in-patients-with-the-heartmate-ii-left-ventricular-assist-device-insights-from-the-prevent-study
#17
Thenappan Thenappan, John M Stulak, Richa Agarwal, Simon Maltais, Palak Shah, Peter Eckman, Sitaramesh Emani, Jason N Katz, Igor Gregoric, Mary E Keebler, Nir Uriel, Eric Adler, Joyce Chuang, David J Farrar, Kartik S Sundareswaran, Ranjit John
BACKGROUND: Hemolysis, assessed by elevated serum lactate dehydrogenase (LDH), is strongly associated with HeartMate II pump thrombosis (PT). However, it is unknown whether early intervention for elevated LDH circumvents the risk of serious PT requiring pump exchange. We sought to evaluate the relationship between elevated LDH and clinical outcomes, the effectiveness of early medical intervention, and risk factors for elevated LDH. METHODS: We studied 268 patients in the prospective, multicenter PREVENT study who had 2 or more LDH measurements at ≥30 days post-implant...
October 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29141856/impact-of-diabetes-mellitus-on-outcomes-in-patients-supported-with-left-ventricular-assist-devices-a-single-institutional-9-year-experience
#18
Rabea Asleh, Alexandros Briasoulis, Sarah D Schettle, Vakhtang Tchantchaleishvili, Naveen L Pereira, Brooks S Edwards, Alfredo L Clavell, Simon Maltais, David L Joyce, Lyle D Joyce, Richard C Daly, Sudhir S Kushwaha, John M Stulak
BACKGROUND: Diabetes mellitus (DM) is a risk factor for morbidity and mortality in patients with heart failure. The effect of DM on post-left ventricular assist device (LVAD) implantation outcomes is unclear. This study sought to investigate whether patients with DM had worse outcomes than patients without DM after LVAD implantation and whether LVAD support resulted in a better control of DM. METHODS AND RESULTS: We retrospectively reviewed 341 consecutive adults who underwent implantation of LVAD from 2007 to 2016...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29105276/quadriceps-muscle-fat-infiltration-is-associated-with-cardiometabolic-risk-in-copd
#19
Isabelle Vivodtzev, Luc Moncharmont, Renaud Tamisier, Jean-Christian Borel, François Arbib, Bernard Wuyam, Patrick Lévy, François Maltais, Gilbert Ferretti, Jean-Louis Pépin
PURPOSE: Losses of peripheral muscle mass and ectopic fat accumulation have been associated with cardiometabolic morbidity in COPD. We aimed at identifying the relationship between quadriceps muscle fat infiltration and cardiovascular risk. MATERIALS AND METHODS: From 2009 to 2014, 78 COPD patients (64 ± 8 years; 80% male) were prospectively included after having given written consent (ethical committee approval number: 2006-A00491-50). The cohort was divided into three groups (tertiles) according to body mass index (BMI), low [15 < BMI≤23·3], middle [23·3 < BMI≤27·6] and high [27·6 < BMI≤36] kg/m²)...
November 3, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29095733/left-lateral-thoracotomy-for-centrifugal-continuous-flow-left-ventricular-assist-device-placement-an-analysis-from-the-mechanical-circulatory-support-research-network
#20
Simon Maltais, Lucman A Anwer, Vakhtang Tchantchaleishvili, Nicholas A Haglund, Shannon M Dunlay, Keith D Aaronson, Francis D Pagani, Jennifer Cowger, Christopher T Salerno, Palak Shah, Zain Khalpey, Jan Schmitto, John M Stulak
Continuous-flow left ventricular assist devices (CF-LVADs) have revolutionized the management of patients with advanced heart failure. Alternative implant strategies are increasingly used for device placement. We reviewed our experience from the Mechanical Circulatory Support Research Network registry with the HeartWare centrifugal CF-LVAD (HVAD). From May 2004 to August 2015, 1,150 patients underwent primary CF-LVAD implantation at our institutions. Within this group, a total of 283 patients (25%) were implanted with the HVAD...
October 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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