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https://www.readbyqxmd.com/read/28179190/species-specific-developmental-timing-is-maintained-by-pluripotent-stem-cells-ex-utero
#1
Christopher Barry, Matthew T Schmitz, Peng Jiang, Michael P Schwartz, Bret M Duffin, Scott Swanson, Rhonda Bacher, Jennifer M Bolin, Angela L Elwell, Brian E McIntosh, Ron Stewart, James A Thomson
How species-specific developmental timing is controlled is largely unknown. By following human embryonic stem (ES) cell and mouse epiblast stem (EpiS) cell differentiation through detailed RNA-sequencing time courses, here we show that pluripotent stem cells closely retain in vivo species-specific developmental timing in vitro. In identical neural differentiation conditions in vitro, gene expression profiles are accelerated in mouse EpiS cells compared to human ES cells with relative rates of differentiation closely reflecting the rates of progression through the Carnegie stages in utero...
February 6, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28148697/updating-the-psoriatic-arthritis-psa-core-domain-set-a-report-from-the-psa-workshop-at-omeract-2016
#2
Ana-Maria Orbai, Maarten de Wit, Philip J Mease, Kristina Callis Duffin, Musaab Elmamoun, William Tillett, Willemina Campbell, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Laure Gossec, Pil Hoejgaard, Ying Ying Leung, Chris Lindsay, Vibeke Strand, Désirée M van der Heijde, Bev Shea, Robin Christensen, Laura Coates, Lihi Eder, Neil McHugh, Umut Kalyoncu, Ingrid Steinkoenig, Alexis Ogdie
OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants...
February 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28137721/transcriptional-functional-and-mechanistic-comparisons-of-stem-cell-derived-hepatocytes-heparg-cells-and-3d-human-hepatocyte-spheroids-as-predictive-in-vitro-systems-for-drug-induced-liver-injury
#3
Catherine C Bell, Volker M Lauschke, Sabine U Vorrink, Henrik Palmgren, Roger Duffin, Tommy B Andersson, Magnus Ingelman-Sundberg
Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics and toxicity are essential constituents of preclinical safety assessment pipelines for new medicines. Here, we compared three emerging cell systems, hepatocytes derived from induced pluripotent stem cells (hiPS-Hep), HepaRG cells and 3D primary human hepatocyte (PHH) spheroids at transcriptional and functional levels in a multi-center study to evaluate their potential as predictive models for drug-induced hepatotoxicity...
January 30, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28099157/high-quality-epitaxial-graphene-by-hydrogen-etching-of-3c-sic-111-thin-film-on-si-111
#4
Pierluigi Mondelli, Bharati Gupta, Maria Grazia Betti, Carlo Mariani, Josh Lipton Duffin, Nunzio Motta
Etching with atomic hydrogen, as a preparation step before the high-temperature growth process of graphene onto a thin 3C-SiC film grown on Si(111), greatly improves the structural quality of topmost graphene layers. Pit formation and island coalescence, which are typical of graphene growth by SiC graphitization, are quenched and accompanied by widening of the graphene domain sizes to hundreds of nanometers, and by a significant reduction in surface roughness down to a single substrate bilayer. The surface reconstructions expected for graphene and the underlying layer are shown with atomic resolution by scanning tunnelling microscopy...
January 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28094620/seacole-campaigner-made-a-dame-in-honours-list
#5
Christian Duffin
A trailblazing nurse who was a leading figure in the Mary Seacole statue campaign has been made a dame in the new year's honours.
January 4, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28075300/leading-clinic-reports-40-drop-in-hiv-diagnoses
#6
Christian Duffin
A nurse-led sexual health clinic has reported a 'significant' 40% fall in HIV diagnoses.
January 11, 2017: Nursing Standard
https://www.readbyqxmd.com/read/27958750/mechanistic-picture-and-kinetic-analysis-of-surface-confined-ullmann-polymerization
#7
Marco Di Giovannantonio, Massimo Tomellini, Josh Lipton-Duffin, Gianluca Galeotti, Maryam Ebrahimi, Albano Cossaro, Alberto Verdini, Neerav Kharche, Vincent Meunier, Guillaume Vasseur, Yannick Fagot-Revurat, Dmitrii F Perepichka, Federico Rosei, Giorgio Contini
Surface-confined polymerization via Ullmann coupling is a promising route to create one- and two-dimensional covalent π-conjugated structures, including the bottom-up growth of graphene nanoribbons. Understanding the mechanism of the Ullmann reaction is necessary to provide a platform for rationally controlling the formation of these materials. We use fast X-ray photoelectron spectroscopy (XPS) in kinetic measurements of epitaxial surface polymerization of 1,4-dibromobenzene on Cu(110) and devise a kinetic model based on mean field rate equations, involving a transient state...
December 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27920011/the-interwoven-history-of-mercury-poisoning-in-ontario-and-japan
#8
Adam Mosa, Jacalyn Duffin
No abstract text is available yet for this article.
December 5, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27908543/from-the-medical-board-of-the-national-psoriasis-foundation-treatment-targets-for-plaque-psoriasis
#9
April W Armstrong, Michael P Siegel, Jerry Bagel, Erin E Boh, Megan Buell, Kevin D Cooper, Kristina Callis Duffin, Lawrence F Eichenfield, Amit Garg, Joel M Gelfand, Alice B Gottlieb, John Y M Koo, Neil J Korman, Gerald G Krueger, Mark G Lebwohl, Craig L Leonardi, Arthur M Mandelin, M Alan Menter, Joseph F Merola, David M Pariser, Ronald B Prussick, Caitriona Ryan, Kara N Shah, Jeffrey M Weinberg, MaryJane O U Williams, Jashin J Wu, Paul S Yamauchi, Abby S Van Voorhees
BACKGROUND: An urgent need exists in the United States to establish treatment goals in psoriasis. OBJECTIVE: We aim to establish defined treatment targets toward which clinicians and patients with psoriasis can strive to inform treatment decisions, reduce disease burden, and improve outcomes in practice. METHODS: The National Psoriasis Foundation conducted a consensus-building study among psoriasis experts using the Delphi method. The process consisted of: (1) literature review, (2) pre-Delphi question selection and input from general dermatologists and patients, and (3) 4 Delphi rounds...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27833165/genetic-and-pharmacological-inhibition-of-cdk9-drives-neutrophil-apoptosis-to-resolve-inflammation-in-zebrafish-in-vivo
#10
Laura J Hoodless, Christopher D Lucas, Rodger Duffin, Martin A Denvir, Christopher Haslett, Carl S Tucker, Adriano G Rossi
Neutrophilic inflammation is tightly regulated and subsequently resolves to limit tissue damage and promote repair. When the timely resolution of inflammation is dysregulated, tissue damage and disease results. One key control mechanism is neutrophil apoptosis, followed by apoptotic cell clearance by phagocytes such as macrophages. Cyclin-dependent kinase (CDK) inhibitor drugs induce neutrophil apoptosis in vitro and promote resolution of inflammation in rodent models. Here we present the first in vivo evidence, using pharmacological and genetic approaches, that CDK9 is involved in the resolution of neutrophil-dependent inflammation...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27794113/cerebrovascular-reactivity-and-white-matter-integrity
#11
Kevin Sam, Boris Peltenburg, John Conklin, Olivia Sobczyk, Julien Poublanc, Adrian P Crawley, Daniel M Mandell, Lakshmikumar Venkatraghavan, James Duffin, Joseph A Fisher, Sandra E Black, David J Mikulis
OBJECTIVE: To compare the diffusion and perfusion MRI metrics of normal-appearing white matter (NAWM) with and without impaired cerebrovascular reactivity (CVR). METHODS: Seventy-five participants with moderate to severe leukoaraiosis underwent blood oxygen level-dependent CVR mapping using a 3T MRI system with precise carbon dioxide stimulus manipulation. Several MRI metrics were statistically compared between areas of NAWM with positive and negative CVR using one-way analysis of variance with Bonferroni correction for multiple comparisons...
November 29, 2016: Neurology
https://www.readbyqxmd.com/read/27785115/usability-of-a-novel-disposable-autoinjector-device-for-ixekizumab-results-from-a-qualitative-study-and-an-open-label-clinical-trial-including-patient-reported-experience
#12
Kristina Callis Duffin, Michael Bukhalo, Margaret A Bobonich, David Shrom, Fangyi Zhao, James R Kershner, Anne Gill, Beth Pangallo, Catherine L Shuler, Jerry Bagel
BACKGROUND: Most biologic therapies for psoriasis are delivered via subcutaneous injection. Ixekizumab, an anti-interleukin 17A monoclonal antibody approved for patients with moderate-to-severe plaque psoriasis, is delivered subcutaneously via prefilled syringe or autoinjector. Here we report the results of an ixekizumab autoinjector usability study as well as the patient-reported experience with the autoinjector in a clinical trial. METHODS: The usability study enrolled 49 subjects (patients with a range of autoimmune conditions or their caregivers)...
2016: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/27725195/cardiovascular-health-effects-of-oral-and-pulmonary-exposure-to-multi-walled-carbon-nanotubes-in-apoe-deficient-mice
#13
Daniel V Christophersen, Nicklas R Jacobsen, Maria H G Andersen, Shea P Connell, Kenneth K Barfod, Morten B Thomsen, Mark R Miller, Rodger Duffin, Jens Lykkesfeldt, Ulla Vogel, Håkan Wallin, Steffen Loft, Martin Roursgaard, Peter Møller
Exposure to high aspect ratio nanomaterials, such as multi-walled carbon nanotubes (MWCNTs) may be associated with increased risk of atherosclerosis, pulmonary disease, and cancer. In the present study, we investigated the cardiovascular and pulmonary health effects of 10 weeks of repeated oral or pulmonary exposures to MWCNTs (4 or 40μg each week) in Apolipoprotein E-deficient (ApoE(-/-)) mice fed a Western-type diet. Intratracheal instillation of MWCNTs was associated with oxidative damage to DNA in lung tissue and elevated levels of lipid peroxidation products in plasma, whereas the exposure only caused a modest pulmonary inflammation in terms of increased numbers of lymphocytes in bronchoalveolar lavage fluid...
October 8, 2016: Toxicology
https://www.readbyqxmd.com/read/27722086/mri-based-cerebrovascular-reactivity-using-transfer-function-analysis-reveals-temporal-group-differences-between-patients-with-sickle-cell-disease-and-healthy-controls
#14
Jackie Leung, James Duffin, Joseph A Fisher, Andrea Kassner
OBJECTIVES: Cerebrovascular reactivity (CVR) measures the ability of cerebral blood vessels to change their diameter and, hence, their capacity to regulate regional blood flow in the brain. High resolution quantitative maps of CVR can be produced using blood-oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) in combination with a carbon dioxide stimulus, and these maps have become a useful tool in the clinical evaluation of cerebrovascular disorders. However, conventional CVR analysis does not fully characterize the BOLD response to a stimulus as certain regions of the brain are slower to react to the stimulus than others, especially in disease...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27647855/anti-tgf-%C3%AE-1-antibody-therapy-in-patients-with-diabetic-nephropathy
#15
James Voelker, Paul H Berg, Matthew Sheetz, Kevin Duffin, Tong Shen, Brian Moser, Tom Greene, Samuel S Blumenthal, Ivan Rychlik, Yoram Yagil, Philippe Zaoui, Julia B Lewis
TGF-β has been implicated as a major pathogenic factor in diabetic nephropathy. This randomized, double-blind, phase 2 study assessed whether modulating TGF-β1 activity with a TGF-β1-specific, humanized, neutralizing monoclonal antibody (TGF-β1 mAb) is safe and more effective than placebo in slowing renal function loss in patients with diabetic nephropathy on chronic stable renin-angiotensin system inhibitor treatment. We randomized 416 patients aged ≥25 years with type 1 or type 2 diabetes, a serum creatinine (SCr) level of 1...
September 19, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27613807/international-patient-and-physician-consensus-on-a-psoriatic-arthritis-core-outcome-set-for-clinical-trials
#16
Ana-Maria Orbai, Maarten de Wit, Philip Mease, Judy A Shea, Laure Gossec, Ying Ying Leung, William Tillett, Musaab Elmamoun, Kristina Callis Duffin, Willemina Campbell, Robin Christensen, Laura Coates, Emma Dures, Lihi Eder, Oliver FitzGerald, Dafna Gladman, Niti Goel, Suzanne Dolwick Grieb, Sarah Hewlett, Pil Hoejgaard, Umut Kalyoncu, Chris Lindsay, Neil McHugh, Bev Shea, Ingrid Steinkoenig, Vibeke Strand, Alexis Ogdie
OBJECTIVE: To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities. METHODS: We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups to identify domains important to people with PsA; (3) two international surveys with patients and physicians to prioritise domains; (4) an international face-to-face meeting with patients and physicians using the nominal group technique method to agree on the most important domains; and (5) presentation and votes at the Outcome Measures in Rheumatology (OMERACT) conference in May 2016...
September 9, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27500949/phase-3-open-label-randomized-study-of-the-pharmacokinetics-efficacy-and-safety-of-ixekizumab-following-subcutaneous-administration-using-a-prefilled-syringe-or-an-autoinjector-in-patients-with-moderate-to-severe-plaque-psoriasis-uncover-a
#17
K Callis Duffin, J Bagel, M Bukhalo, I J Mercado Clement, S L Choi, F Zhao, A Gill, B Pangallo, C Shuler, L Mallbris, K Jackson
BACKGROUND: The efficacy of ixekizumab, an anti-interleukin-17A (anti-IL-17A) monoclonal IgG4 antibody, was demonstrated in moderate-to-severe psoriasis patients when administered via prefilled syringe (PFS). OBJECTIVE: To evaluate the effect of two drug delivery devices on the pharmacokinetics (PK) of ixekizumab as well as efficacy and safety with both devices. METHODS: In the first 12 weeks of an open-label, phase 3 study, moderate-to-severe psoriasis patients were randomized to ixekizumab delivery via PFS or autoinjector device...
January 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27492072/vascular-dysfunction-in-leukoaraiosis
#18
K Sam, A P Crawley, J Poublanc, J Conklin, O Sobczyk, D M Mandell, J Duffin, L Venkatraghavan, J A Fisher, S E Black, D J Mikulis
BACKGROUND AND PURPOSE: The pathogenesis of leukoaraiosis has long been debated. This work addresses a less well-studied mechanism, cerebrovascular reactivity, which could play a leading role in the pathogenesis of this disease. Our aim was to evaluate blood flow dysregulation and its relation to leukoaraiosis. MATERIALS AND METHODS: Cerebrovascular reactivity, the change in the blood oxygen level-dependent 3T MR imaging signal in response to a consistently applied step change in the arterial partial pressure of carbon dioxide, was measured in white matter hyperintensities and their contralateral spatially homologous normal-appearing white matter in 75 older subjects (age range, 50-91 years; 40 men) with leukoaraiosis...
December 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27469477/dpra-is-required-for-natural-transformation-and-affects-pilin-variation-in-neisseria-gonorrhoeae
#19
Paul M Duffin, Daniel A Barber
Natural transformation is the main means of horizontal genetic exchange in the obligate human pathogen Neisseria gonorrhoeae and drives the spread of antibiotic resistance and virulence determinants. Transformation can be divided into four steps: (1) DNA binding, (2) DNA uptake, (3) DNA processing and (4) DNA recombination into the chromosome. The DNA processing enzyme DprA has been shown to shuttle incoming ssDNA to the recombination enzyme RecA during transformation in Bacillus subtilis and Streptococcus pneumoniae...
September 2016: Microbiology
https://www.readbyqxmd.com/read/27458426/longitudinal-brain-magnetic-resonance-imaging-co2-stress-testing-in-individual-adolescent-sports-related-concussion-patients-%C3%A2-a-pilot-study
#20
W Alan C Mutch, Michael J Ellis, Lawrence N Ryner, Marc P Morissette, Philip J Pries, Brenden Dufault, Marco Essig, David J Mikulis, James Duffin, Joseph A Fisher
BACKGROUND: Advanced neuroimaging studies in concussion have been limited to detecting group differences between concussion patients and healthy controls. In this small pilot study, we used brain magnetic resonance imaging (MRI) CO2 stress testing to longitudinally assess cerebrovascular responsiveness (CVR) in individual sports-related concussion (SRC) patients. METHODS: Six SRC patients (three males and three females; mean age = 15.7, range = 15-17 years) underwent longitudinal brain MRI CO2 stress testing using blood oxygen level-dependent (BOLD) MRI and model-based prospective end-tidal CO2 targeting under isoxic conditions...
2016: Frontiers in Neurology
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