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https://www.readbyqxmd.com/read/28397886/2d-supramolecular-networks-of-dibenzonitrilediacetylene-on-ag-111-stabilized-by-intermolecular-hydrogen-bonding
#1
G Galeotti, M Ebrahimi, J Lipton-Duffin, J M MacLeod, S Rondeau-Gagné, J-F Morin, F Rosei
The two-dimensional (2D) surface-directed self-assembly of dibenzonitrile diacetylene (DBDA) on Ag(111) under ultrahigh vacuum (UHV) conditions was investigated by combining scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS) and theoretical simulations based on density functional theory (DFT) calculations. The molecule consists of two benzonitrile groups (-C6H4-C[triple bond, length as m-dash]N) on each side of a diacetylene (-C[triple bond, length as m-dash]C-C[triple bond, length as m-dash]C-) backbone...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28396115/improved-clinical-trial-enrollment-criterion-to-identify-patients-with-diabetes-at-risk-of-end-stage-renal-disease
#2
Masayuki Yamanouchi, Jan Skupien, Monika A Niewczas, Adam M Smiles, Alessandro Doria, Robert C Stanton, Andrzej T Galecki, Kevin L Duffin, Nick Pullen, Matthew D Breyer, Joseph V Bonventre, James H Warram, Andrzej S Krolewski
Design of Phase III trials for diabetic nephropathy currently requires patients at a high risk of progression defined as within three years of a hard end point (end-stage renal disease, 40% loss of estimated glomerular filtration rate, or death). To improve the design of these trials, we used natural history data from the Joslin Kidney Studies of chronic kidney disease in patients with diabetes to develop an improved criterion to identify such patients. This included a training cohort of 279 patients with type 1 diabetes and 134 end points within three years, and a validation cohort of 221 patients with type 2 diabetes and 88 end points...
April 7, 2017: Kidney International
https://www.readbyqxmd.com/read/28370825/assessing-cerebrovascular-reactivity-by-the-pattern-of-response-to-progressive-hypercapnia
#3
Joseph A Fisher, Olivia Sobczyk, Adrian Crawley, Julien Poublanc, Paul Dufort, Lashmi Venkatraghavan, Kevin Sam, David Mikulis, James Duffin
Cerebral blood flow responds to a carbon dioxide challenge, and is often assessed as cerebrovascular reactivity, assuming a linear response over a limited stimulus range or a sigmoidal response over a wider range. However, these assumed response patterns may not necessarily apply to regions with pathophysiology. Deviations from sigmoidal responses are hypothesised to result from upstream flow limitations causing competition for blood flow between downstream regions, particularly with vasodilatory stimulation; flow is preferentially distributed to regions with more reactive vessels...
April 3, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28300857/evaluation-of-the-physician-global-assessment-and-body-surface-area-composite-tool-for-assessing-psoriasis-response-to-apremilast-therapy-results-from-esteem-1-and-esteem-2
#4
Kristina C Duffin, Kim A Papp, Jerry Bagel, Eugenia Levi, Rongdean Chen, Alice B Gottlieb
BACKGROUND: The Physician Global Assessment and Body Surface Area (PGAxBSA) composite tool is a simple, effective alternative for measuring psoriasis severity. OBJECTIVE: To evaluate the product of PGAxBSA as a sensitive alternative to the Psoriasis Area and Severity Index (PASI) for assessing disease severity and therapeutic response with data collected from the phase 3 ESTEEM 1 and 2 trials. METHODS: This post hoc analysis included 836 patients randomized to apremilast 30 mg BID at baseline (ESTEEM 1, n=562; ESTEEM 2, n=274)...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300853/the-international-dermatology-outcome-measures-ideom-initiative-a-review-and-update
#5
Scott A Elman, Joseph F Merola, April W Armstrong, Kristina Callis Duffin, John Latella, Amit Garg, Alice B Gottlieb
<p>The International Dermatology Outcome Measures (IDEOM) group, comprising patients, physicians, health economists, industry partners, payers, and regulatory agencies, was established to develop unified and validated patient-centered outcome measures in dermatology in response to increasing demand to quantify effectiveness of treatments and performance outcomes among providers. IDEOM has chosen to start with psoriasis outcome measures, and then apply its methodology to other dermatologic diseases. In this paper, we review the background and progress to date of IDEOM, including an update of IDEOM activities as of our 2016 meeting in Washington DC, USA...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28281948/response-to-letter-to-the-editor
#6
Jeremy Horst, John C Frachella, Steve Duffin
No abstract text is available yet for this article.
November 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28262053/five-year-plan-will-revamp-neonatal-services-in-scotland
#7
Christian Duffin
The Scottish Government is considering recommendations for a revamp of neonatal services - including creating three specialist neonatal intensive care units in the next five years.
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28179190/species-specific-developmental-timing-is-maintained-by-pluripotent-stem-cells-ex-utero
#8
Christopher Barry, Matthew T Schmitz, Peng Jiang, Michael P Schwartz, Bret M Duffin, Scott Swanson, Rhonda Bacher, Jennifer M Bolin, Angela L Elwell, Brian E McIntosh, Ron Stewart, James A Thomson
How species-specific developmental timing is controlled is largely unknown. By following human embryonic stem (ES) cell and mouse epiblast stem (EpiS) cell differentiation through detailed RNA-sequencing time courses, here we show that pluripotent stem cells closely retain in vivo species-specific developmental timing in vitro. In identical neural differentiation conditions in vitro, gene expression profiles are accelerated in mouse EpiS cells compared to human ES cells with relative rates of differentiation closely reflecting the rates of progression through the Carnegie stages in utero...
March 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28148697/updating-the-psoriatic-arthritis-psa-core-domain-set-a-report-from-the-psa-workshop-at-omeract-2016
#9
Ana-Maria Orbai, Maarten de Wit, Philip J Mease, Kristina Callis Duffin, Musaab Elmamoun, William Tillett, Willemina Campbell, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Laure Gossec, Pil Hoejgaard, Ying Ying Leung, Chris Lindsay, Vibeke Strand, Désirée M van der Heijde, Bev Shea, Robin Christensen, Laura Coates, Lihi Eder, Neil McHugh, Umut Kalyoncu, Ingrid Steinkoenig, Alexis Ogdie
OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants...
February 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28137721/transcriptional-functional-and-mechanistic-comparisons-of-stem-cell-derived-hepatocytes-heparg-cells-and-three-dimensional-human-hepatocyte-spheroids-as-predictive-in-vitro-systems-for-drug-induced-liver-injury
#10
Catherine C Bell, Volker M Lauschke, Sabine U Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B Andersson, Magnus Ingelman-Sundberg
Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics and toxicity are essential constituents of preclinical safety assessment pipelines for new medicines. Here, we compared three emerging cell systems-hepatocytes derived from induced pluripotent stem cells, HepaRG cells, and three-dimensional primary human hepatocyte (PHH) spheroids-at transcriptional and functional levels in a multicenter study to evaluate their potential as predictive models for drug-induced hepatotoxicity...
April 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28099157/high-quality-epitaxial-graphene-by-hydrogen-etching-of-3c-sic-111-thin-film-on-si-111
#11
Pierluigi Mondelli, Bharati Gupta, Maria Grazia Betti, Carlo Mariani, Josh Lipton Duffin, Nunzio Motta
Etching with atomic hydrogen, as a preparation step before the high-temperature growth process of graphene onto a thin 3C-SiC film grown on Si(111), greatly improves the structural quality of topmost graphene layers. Pit formation and island coalescence, which are typical of graphene growth by SiC graphitization, are quenched and accompanied by widening of the graphene domain sizes to hundreds of nanometers, and by a significant reduction in surface roughness down to a single substrate bilayer. The surface reconstructions expected for graphene and the underlying layer are shown with atomic resolution by scanning tunnelling microscopy...
January 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28094620/seacole-campaigner-made-a-dame-in-honours-list
#12
Christian Duffin
A trailblazing nurse who was a leading figure in the Mary Seacole statue campaign has been made a dame in the new year's honours.
January 4, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28075300/leading-clinic-reports-40-drop-in-hiv-diagnoses
#13
Christian Duffin
A nurse-led sexual health clinic has reported a 'significant' 40% fall in HIV diagnoses.
January 11, 2017: Nursing Standard
https://www.readbyqxmd.com/read/27958750/mechanistic-picture-and-kinetic-analysis-of-surface-confined-ullmann-polymerization
#14
Marco Di Giovannantonio, Massimo Tomellini, Josh Lipton-Duffin, Gianluca Galeotti, Maryam Ebrahimi, Albano Cossaro, Alberto Verdini, Neerav Kharche, Vincent Meunier, Guillaume Vasseur, Yannick Fagot-Revurat, Dmitrii F Perepichka, Federico Rosei, Giorgio Contini
Surface-confined polymerization via Ullmann coupling is a promising route to create one- and two-dimensional covalent π-conjugated structures, including the bottom-up growth of graphene nanoribbons. Understanding the mechanism of the Ullmann reaction is necessary to provide a platform for rationally controlling the formation of these materials. We use fast X-ray photoelectron spectroscopy (XPS) in kinetic measurements of epitaxial surface polymerization of 1,4-dibromobenzene on Cu(110) and devise a kinetic model based on mean field rate equations, involving a transient state...
December 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27920011/the-interwoven-history-of-mercury-poisoning-in-ontario-and-japan
#15
Adam Mosa, Jacalyn Duffin
No abstract text is available yet for this article.
February 6, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27908543/from-the-medical-board-of-the-national-psoriasis-foundation-treatment-targets-for-plaque-psoriasis
#16
April W Armstrong, Michael P Siegel, Jerry Bagel, Erin E Boh, Megan Buell, Kevin D Cooper, Kristina Callis Duffin, Lawrence F Eichenfield, Amit Garg, Joel M Gelfand, Alice B Gottlieb, John Y M Koo, Neil J Korman, Gerald G Krueger, Mark G Lebwohl, Craig L Leonardi, Arthur M Mandelin, M Alan Menter, Joseph F Merola, David M Pariser, Ronald B Prussick, Caitriona Ryan, Kara N Shah, Jeffrey M Weinberg, MaryJane O U Williams, Jashin J Wu, Paul S Yamauchi, Abby S Van Voorhees
BACKGROUND: An urgent need exists in the United States to establish treatment goals in psoriasis. OBJECTIVE: We aim to establish defined treatment targets toward which clinicians and patients with psoriasis can strive to inform treatment decisions, reduce disease burden, and improve outcomes in practice. METHODS: The National Psoriasis Foundation conducted a consensus-building study among psoriasis experts using the Delphi method. The process consisted of: (1) literature review, (2) pre-Delphi question selection and input from general dermatologists and patients, and (3) 4 Delphi rounds...
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27833165/genetic-and-pharmacological-inhibition-of-cdk9-drives-neutrophil-apoptosis-to-resolve-inflammation-in-zebrafish-in-vivo
#17
Laura J Hoodless, Christopher D Lucas, Rodger Duffin, Martin A Denvir, Christopher Haslett, Carl S Tucker, Adriano G Rossi
Neutrophilic inflammation is tightly regulated and subsequently resolves to limit tissue damage and promote repair. When the timely resolution of inflammation is dysregulated, tissue damage and disease results. One key control mechanism is neutrophil apoptosis, followed by apoptotic cell clearance by phagocytes such as macrophages. Cyclin-dependent kinase (CDK) inhibitor drugs induce neutrophil apoptosis in vitro and promote resolution of inflammation in rodent models. Here we present the first in vivo evidence, using pharmacological and genetic approaches, that CDK9 is involved in the resolution of neutrophil-dependent inflammation...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27794113/cerebrovascular-reactivity-and-white-matter-integrity
#18
Kevin Sam, Boris Peltenburg, John Conklin, Olivia Sobczyk, Julien Poublanc, Adrian P Crawley, Daniel M Mandell, Lakshmikumar Venkatraghavan, James Duffin, Joseph A Fisher, Sandra E Black, David J Mikulis
OBJECTIVE: To compare the diffusion and perfusion MRI metrics of normal-appearing white matter (NAWM) with and without impaired cerebrovascular reactivity (CVR). METHODS: Seventy-five participants with moderate to severe leukoaraiosis underwent blood oxygen level-dependent CVR mapping using a 3T MRI system with precise carbon dioxide stimulus manipulation. Several MRI metrics were statistically compared between areas of NAWM with positive and negative CVR using one-way analysis of variance with Bonferroni correction for multiple comparisons...
November 29, 2016: Neurology
https://www.readbyqxmd.com/read/27785115/usability-of-a-novel-disposable-autoinjector-device-for-ixekizumab-results-from-a-qualitative-study-and-an-open-label-clinical-trial-including-patient-reported-experience
#19
Kristina Callis Duffin, Michael Bukhalo, Margaret A Bobonich, David Shrom, Fangyi Zhao, James R Kershner, Anne Gill, Beth Pangallo, Catherine L Shuler, Jerry Bagel
BACKGROUND: Most biologic therapies for psoriasis are delivered via subcutaneous injection. Ixekizumab, an anti-interleukin 17A monoclonal antibody approved for patients with moderate-to-severe plaque psoriasis, is delivered subcutaneously via prefilled syringe or autoinjector. Here we report the results of an ixekizumab autoinjector usability study as well as the patient-reported experience with the autoinjector in a clinical trial. METHODS: The usability study enrolled 49 subjects (patients with a range of autoimmune conditions or their caregivers)...
2016: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/27725195/cardiovascular-health-effects-of-oral-and-pulmonary-exposure-to-multi-walled-carbon-nanotubes-in-apoe-deficient-mice
#20
Daniel V Christophersen, Nicklas R Jacobsen, Maria H G Andersen, Shea P Connell, Kenneth K Barfod, Morten B Thomsen, Mark R Miller, Rodger Duffin, Jens Lykkesfeldt, Ulla Vogel, Håkan Wallin, Steffen Loft, Martin Roursgaard, Peter Møller
Exposure to high aspect ratio nanomaterials, such as multi-walled carbon nanotubes (MWCNTs) may be associated with increased risk of atherosclerosis, pulmonary disease, and cancer. In the present study, we investigated the cardiovascular and pulmonary health effects of 10 weeks of repeated oral or pulmonary exposures to MWCNTs (4 or 40μg each week) in Apolipoprotein E-deficient (ApoE(-/-)) mice fed a Western-type diet. Intratracheal instillation of MWCNTs was associated with oxidative damage to DNA in lung tissue and elevated levels of lipid peroxidation products in plasma, whereas the exposure only caused a modest pulmonary inflammation in terms of increased numbers of lymphocytes in bronchoalveolar lavage fluid...
September 14, 2016: Toxicology
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