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https://www.readbyqxmd.com/read/28617118/not-enough-is-done-to-cut-risk-of-death-after-cardiac-arrest
#1
Christian Duffin
How much is being done to cut the number of people who die after cardiac arrests in public places? Not enough, says a group of cardiac experts and campaigners on the Out of Hospital Cardiac Arrest (OHCA) steering group.
June 15, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28600818/extension-of-ustekinumab-maintenance-dosing-interval-in-moderate-to-severe-psoriasis-results-of-a-phase-3b-randomized-double-blinded-active-controlled-multicenter-study-pstellar
#2
A Blauvelt, L K Ferris, P S Yamauchi, A Qureshi, C L Leonardi, K Farahi, S Fakharzadeh, M-C Hsu, S Li, M Chevrier, K Smith, K Goyal, Y Chen, E J Muñoz-Elías, K Callis Duffin
BACKGROUND: Phase 3 studies showed some patients maintained response for ≥6 months post-ustekinumab discontinuation. OBJECTIVES: To assess clinical responses with extended ustekinumab maintenance dosing intervals. METHODS: Adults with moderate-to-severe plaque psoriasis received ustekinumab (45mg/90mg for weight ≤100 kg/>100 kg) at Week0, Week4, Week16 during open-label treatment. Patients achieving a Week 28 Physician's Global Assessment score of cleared/minimal (PGA=0/1) were randomized 1:4 to Group1 (approved every-12-weeks [q12wk] maintenance) or Group2 (q12-24wk response-based dosing determined by time-to-loss-of-PGA=0/1)...
June 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28548043/epitaxial-graphene-growth-on-fib-patterned-3c-sic-nanostructures-on-si-111-reducing-milling-damage
#3
Mojtaba Amjadipour, Jennifer MacLeod, Josh Lipton-Duffin, Francesca Iacopi, Nunzio Motta
Epitaxial growth of graphene on SiC is a scalable procedure which does not require any further transfer step, making this an ideal platform for graphene nanostructure fabrication. Focused ion beam (FIB) is a very promising tool for exploring the reduction of the lateral dimension of graphene on SiC to the nanometre scale. However, exposure of graphene to the Ga+ beam causes significant surface damage through amorphisation and contamination, preventing epitaxial graphene growth. In this paper we demonstrate that combining a protective silicon layer with FIB patterning implemented prior to graphene growth can significantly reduce the damage associated with FIB milling...
May 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28537254/large-scale-meta-analysis-characterizes-genetic-architecture-for-common-psoriasis-associated-variants
#4
Lam C Tsoi, Philip E Stuart, Chao Tian, Johann E Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G Krueger, Henry W Lim, Andres Metspalu, Ulrich Mrowietz, Sören Mucha, Proton Rahman, Andre Reis, Trilokraj Tejasvi, Richard Trembath, John J Voorhees, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, Nicholas Eriksson, Hyun M Kang, David A Hinds, Rajan P Nair, Gonçalo R Abecasis, James T Elder
Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFκB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8(+) T-cells and CD4(+) T-cells including TH0, TH1 and TH17)...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28494660/young-people-s-changing-demands-for-emergency-services
#5
Christian Duffin
A ten-year study has highlighted some eye-opening statistics concerning children and emergency care: significantly more children are now being admitted for jaundice, acute bronchitis, acute and chronic tonsillitis, and viral infections.
May 12, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28461534/grappa-2016-project-report
#6
Philip S Helliwell, Oliver FitzGerald, Laura C Coates, Kristina Callis Duffin, Philip J Mease
At the 2016 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members received updates on several ongoing research and educational efforts. Among them were updates on the FLARE instrument, the Biomarker Project, GRAPPA's logo and Website, continuing progress on the video training project, and numerous educational project efforts in 2016.
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28461532/defining-outcome-measures-for-psoriasis-the-ideom-report-from-the-grappa-2016-annual-meeting
#7
Kristina Callis Duffin, Alice B Gottlieb, Joseph F Merola, John Latella, Amit Garg, April W Armstrong
The International Dermatology Outcome Measures (IDEOM) psoriasis working group was established to develop core domains and measurements sets for psoriasis clinical trials and ultimately clinical practice. At the 2016 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis, the IDEOM psoriasis group presented an overview of its progress toward developing this psoriasis core domain set. First, it summarized the February 2016 meeting of all involved with the IDEOM, highlighting patient and payer perspectives on outcome measures...
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28461531/defining-outcome-measures-for-psoriatic-arthritis-a-report-from-the-grappa-omeract-working-group
#8
Alexis Ogdie, Maarten de Wit, Kristina Callis Duffin, Willemina Campbell, Jeffrey Chau, Laura C Coates, Lihi Eder, Musaab Elmamoun, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Jana James, Umut Kalyoncu, John Latella, Chris Lindsay, Philip J Mease, Denis O'Sullivan, Ingrid Steinkoenig, Vibeke Strand, William Tillett, Ana-Maria Orbai
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis (PsA) Core Set working group recently published the updated 2016 psoriatic arthritis (PsA) core domain set, a set of disease features that should be measured in all clinical trials. At the GRAPPA annual meeting in July 2016, the PsA working group presented the updated PsA core domain set endorsed by 90% of participants at OMERACT in May 2016 and drafted a roadmap for the development of the PsA core outcome measurement set...
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28461522/proceedings-of-the-grappa-2016-retreat
#9
Deepak R Jadon, Dafna D Gladman, Philip J Mease, Oliver FitzGerald, Vinod Chandran, Niti Goel, Cheryl F Rosen, Walter P Maksymowych, Christopher T Ritchlin, Alexis Ogdie, Laura C Coates, Alberto Cauli, Enrique R Soriano, M Elaine Husni, Willemina Campbell, Valderilio F Azevedo, Kristina Callis Duffin, April W Armstrong, Alice B Gottlieb, Arthur Kavanaugh, Amit Garg, Philip S Helliwell
In advance of its 2016 annual meeting, members of the steering committee of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) convened for a strategic planning meeting. The purpose of this advance meeting was to review the work of GRAPPA since its inception in 2003, ascertain and review the current priorities of the group, and devise a strategy for proceeding. The key accomplishments of GRAPPA to date, priorities and objectives for the next 5 years, and goals and opportunities for the GRAPPA committees were discussed...
May 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28443337/inhaled-nanoparticles-accumulate-at-sites-of-vascular-disease
#10
Mark R Miller, Jennifer B Raftis, Jeremy P Langrish, Steven G McLean, Pawitrabhorn Samutrtai, Shea P Connell, Simon Wilson, Alex T Vesey, Paul H B Fokkens, A John F Boere, Petra Krystek, Colin J Campbell, Patrick W F Hadoke, Ken Donaldson, Flemming R Cassee, David E Newby, Rodger Duffin, Nicholas L Mills
The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and Raman microscopy...
May 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28397886/2d-supramolecular-networks-of-dibenzonitrilediacetylene-on-ag-111-stabilized-by-intermolecular-hydrogen-bonding
#11
G Galeotti, M Ebrahimi, J Lipton-Duffin, J M MacLeod, S Rondeau-Gagné, J-F Morin, F Rosei
The two-dimensional (2D) surface-directed self-assembly of dibenzonitrile diacetylene (DBDA) on Ag(111) under ultrahigh vacuum (UHV) conditions was investigated by combining scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS) and theoretical simulations based on density functional theory (DFT) calculations. The molecule consists of two benzonitrile groups (-C6H4-C[triple bond, length as m-dash]N) on each side of a diacetylene (-C[triple bond, length as m-dash]C-C[triple bond, length as m-dash]C-) backbone...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28396115/improved-clinical-trial-enrollment-criterion-to-identify-patients-with-diabetes-at-risk-of-end-stage-renal-disease
#12
Masayuki Yamanouchi, Jan Skupien, Monika A Niewczas, Adam M Smiles, Alessandro Doria, Robert C Stanton, Andrzej T Galecki, Kevin L Duffin, Nick Pullen, Matthew D Breyer, Joseph V Bonventre, James H Warram, Andrzej S Krolewski
Design of Phase III trials for diabetic nephropathy currently requires patients at a high risk of progression defined as within three years of a hard end point (end-stage renal disease, 40% loss of estimated glomerular filtration rate, or death). To improve the design of these trials, we used natural history data from the Joslin Kidney Studies of chronic kidney disease in patients with diabetes to develop an improved criterion to identify such patients. This included a training cohort of 279 patients with type 1 diabetes and 134 end points within three years, and a validation cohort of 221 patients with type 2 diabetes and 88 end points...
April 7, 2017: Kidney International
https://www.readbyqxmd.com/read/28370825/assessing-cerebrovascular-reactivity-by-the-pattern-of-response-to-progressive-hypercapnia
#13
Joseph A Fisher, Olivia Sobczyk, Adrian Crawley, Julien Poublanc, Paul Dufort, Lashmi Venkatraghavan, Kevin Sam, David Mikulis, James Duffin
Cerebral blood flow responds to a carbon dioxide challenge, and is often assessed as cerebrovascular reactivity, assuming a linear response over a limited stimulus range or a sigmoidal response over a wider range. However, these assumed response patterns may not necessarily apply to regions with pathophysiology. Deviations from sigmoidal responses are hypothesised to result from upstream flow limitations causing competition for blood flow between downstream regions, particularly with vasodilatory stimulation; flow is preferentially distributed to regions with more reactive vessels...
April 3, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28300857/evaluation-of-the-physician-global-assessment-and-body-surface-area-composite-tool-for-assessing-psoriasis-response-to-apremilast-therapy-results-from-esteem-1-and-esteem-2
#14
Kristina C Duffin, Kim A Papp, Jerry Bagel, Eugenia Levi, Rongdean Chen, Alice B Gottlieb
BACKGROUND: The Physician Global Assessment and Body Surface Area (PGAxBSA) composite tool is a simple, effective alternative for measuring psoriasis severity. OBJECTIVE: To evaluate the product of PGAxBSA as a sensitive alternative to the Psoriasis Area and Severity Index (PASI) for assessing disease severity and therapeutic response with data collected from the phase 3 ESTEEM 1 and 2 trials. METHODS: This post hoc analysis included 836 patients randomized to apremilast 30 mg BID at baseline (ESTEEM 1, n=562; ESTEEM 2, n=274)...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300853/the-international-dermatology-outcome-measures-ideom-initiative-a-review-and-update
#15
Scott A Elman, Joseph F Merola, April W Armstrong, Kristina Callis Duffin, John Latella, Amit Garg, Alice B Gottlieb
<p>The International Dermatology Outcome Measures (IDEOM) group, comprising patients, physicians, health economists, industry partners, payers, and regulatory agencies, was established to develop unified and validated patient-centered outcome measures in dermatology in response to increasing demand to quantify effectiveness of treatments and performance outcomes among providers. IDEOM has chosen to start with psoriasis outcome measures, and then apply its methodology to other dermatologic diseases. In this paper, we review the background and progress to date of IDEOM, including an update of IDEOM activities as of our 2016 meeting in Washington DC, USA...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28281948/response-to-letter-to-the-editor
#16
Jeremy Horst, John C Frachella, Steve Duffin
No abstract text is available yet for this article.
November 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28262053/five-year-plan-will-revamp-neonatal-services-in-scotland
#17
Christian Duffin
The Scottish Government is considering recommendations for a revamp of neonatal services - including creating three specialist neonatal intensive care units in the next five years.
March 6, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28179190/species-specific-developmental-timing-is-maintained-by-pluripotent-stem-cells-ex-utero
#18
Christopher Barry, Matthew T Schmitz, Peng Jiang, Michael P Schwartz, Bret M Duffin, Scott Swanson, Rhonda Bacher, Jennifer M Bolin, Angela L Elwell, Brian E McIntosh, Ron Stewart, James A Thomson
How species-specific developmental timing is controlled is largely unknown. By following human embryonic stem (ES) cell and mouse epiblast stem (EpiS) cell differentiation through detailed RNA-sequencing time courses, here we show that pluripotent stem cells closely retain in vivo species-specific developmental timing in vitro. In identical neural differentiation conditions in vitro, gene expression profiles are accelerated in mouse EpiS cells compared to human ES cells with relative rates of differentiation closely reflecting the rates of progression through the Carnegie stages in utero...
March 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28148697/updating-the-psoriatic-arthritis-psa-core-domain-set-a-report-from-the-psa-workshop-at-omeract-2016
#19
Ana-Maria Orbai, Maarten de Wit, Philip J Mease, Kristina Callis Duffin, Musaab Elmamoun, William Tillett, Willemina Campbell, Oliver FitzGerald, Dafna D Gladman, Niti Goel, Laure Gossec, Pil Hoejgaard, Ying Ying Leung, Chris Lindsay, Vibeke Strand, Désirée M van der Heijde, Bev Shea, Robin Christensen, Laura Coates, Lihi Eder, Neil McHugh, Umut Kalyoncu, Ingrid Steinkoenig, Alexis Ogdie
OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS). METHODS: At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants...
February 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28137721/transcriptional-functional-and-mechanistic-comparisons-of-stem-cell-derived-hepatocytes-heparg-cells-and-three-dimensional-human-hepatocyte-spheroids-as-predictive-in-vitro-systems-for-drug-induced-liver-injury
#20
Catherine C Bell, Volker M Lauschke, Sabine U Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B Andersson, Magnus Ingelman-Sundberg
Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics and toxicity are essential constituents of preclinical safety assessment pipelines for new medicines. Here, we compared three emerging cell systems-hepatocytes derived from induced pluripotent stem cells, HepaRG cells, and three-dimensional primary human hepatocyte (PHH) spheroids-at transcriptional and functional levels in a multicenter study to evaluate their potential as predictive models for drug-induced hepatotoxicity...
April 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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