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https://www.readbyqxmd.com/read/28820181/microglia-activation-in-subjects-at-risk-for-psychosis-fact-or-fiction
#1
Patricio O'Donnell
Neuropsychopharmacology accepted article preview online, 18 August 2017. doi:10.1038/npp.2017.179.
August 18, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28819013/yaron-fuchs-exploring-the-mysterious-mixture-of-life-and-death
#2
Marie Anne O'Donnell
Fuchs studies how cell death controls stem cell-driven processes.
August 17, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28817753/efficacy-and-safety-of-durvalumab-in-locally-advanced-or-metastatic-urothelial-carcinoma-updated-results-from-a-phase-1-2-open-label-study
#3
Thomas Powles, Peter H O'Donnell, Christophe Massard, Hendrik-Tobias Arkenau, Terence W Friedlander, Christopher J Hoimes, Jae Lyun Lee, Michael Ong, Srikala S Sridhar, Nicholas J Vogelzang, Mayer N Fishman, Jingsong Zhang, Sandy Srinivas, Jigar Parikh, Joyce Antal, Xiaoping Jin, Ashok K Gupta, Yong Ben, Noah M Hahn
Importance: The data reported herein were accepted for assessment by the US Food and Drug Administration for Biologics License Application under priority review to establish the clinical benefit of durvalumab as second-line therapy for locally advanced or metastatic urothelial carcinoma (UC), resulting in its recent US approval. Objective: To report a planned update of the safety and efficacy of durvalumab in patients with locally advanced/metastatic UC. Design, Setting, and Participants: This is an ongoing phase 1/2 open-label study of 191 adult patients with histologically or cytologically confirmed locally advanced/metastatic UC whose disease had progressed on, were ineligible for, or refused prior chemotherapy from 60 sites in 9 countries as reported herein...
August 17, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28817719/t-cell-expression-of-il-18r-and-dr3-is-essential-for-non-cognate-stimulation-of-th1-cells-and-optimal-clearance-of-intracellular-bacteria
#4
Oanh H Pham, Hope O'Donnell, Aymen Al-Shamkhani, Tobias Kerrinnes, Renée M Tsolis, Stephen J McSorley
Th1 cells can be activated by TCR-independent stimuli, but the importance of this pathway in vivo and the precise mechanisms involved require further investigation. Here, we used a simple model of non-cognate Th1 cell stimulation in Salmonella-infected mice to examine these issues. CD4 Th1 cell expression of both IL-18R and DR3 was required for optimal IFN-γ induction in response to non-cognate stimulation, while IL-15R expression was dispensable. Interestingly, effector Th1 cells generated by immunization rather than live infection had lower non-cognate activity despite comparable IL-18R and DR3 expression...
August 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28815458/backbone-and-side-chain-resonance-assignments-of-ca-2-4-calmodulin-bound-to-beta-calcineurin-a-cambd-peptide
#5
C Andrew Fowler, Maria F Núñez Hernandez, Susan E O'Donnell, Liping Yu, Madeline A Shea
Calcineurin (CaN) is a heterodimeric and highly conserved serine/threonine phosphatase (PP2B) that plays a critical role in coupling calcium signals to physiological processes including embryonic cardiac development, NF-AT-regulated gene expression in immune responses, and apoptosis. The catalytic subunit (CaNA) has three isoforms (α, β, and γ,) in humans and seven isoforms in Paramecium. In all eukaryotes, the EF-hand protein calmodulin (CaM) regulates CaN activity in a calcium-dependent manner. The N- and C-domains of CaM (CaMN and CaMC) recognize a CaM-binding domain (CaMBD) within an intrinsically disordered region of CaNA that precedes the auto-inhibitory domain (AID) of CaNA...
August 16, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28815048/society-for-immunotherapy-of-cancer-consensus-statement-on-immunotherapy-for-the-treatment-of-bladder-carcinoma
#6
Ashish M Kamat, Joaquim Bellmunt, Matthew D Galsky, Badrinath R Konety, Donald L Lamm, David Langham, Cheryl T Lee, Matthew I Milowsky, Michael A O'Donnell, Peter H O'Donnell, Daniel P Petrylak, Padmanee Sharma, Eila C Skinner, Guru Sonpavde, John A Taylor, Prasanth Abraham, Jonathan E Rosenberg
The standard of care for most patients with non-muscle-invasive bladder cancer (NMIBC) is immunotherapy with intravesical Bacillus Calmette-Guérin (BCG), which activates the immune system to recognize and destroy malignant cells and has demonstrated durable clinical benefit. Urologic best-practice guidelines and consensus reports have been developed and strengthened based on data on the timing, dose, and duration of therapy from randomized clinical trials, as well as by critical evaluation of criteria for progression...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28810685/characterising-the-exposure-of-prison-staff-to-second-hand-tobacco-smoke
#7
Sean Semple, Helen Sweeting, Evangelia Demou, Greig Logan, Rachel O'Donnell, Kate Hunt
Second-hand tobacco smoke (SHS) is an avoidable and harmful exposure in the workplace but >25000 prison staff continue to be exposed on a daily basis in the UK and many more worldwide. SHS exposures in prisons are incompletely understood but may be considerable given the large proportion of smoking prisoners and limited ventilation. This study characterized the exposure of prison staff to SHS in all 15 prisons in Scotland using multiple methods. Exposure assessment strategies included 6-day area measurement of fine Particulate Matter (PM2...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28808899/sudden-cardiac-death-from-aortoesophageal-fistula-an-autopsy-case-report-of-a-rare-complication-of-thoracic-aortic-aneurysm
#8
Daniel Chan, Chris O'Donnell, Sarah Parsons
No abstract text is available yet for this article.
August 14, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28807910/24-hour-pharmacokinetic-relationships-for-vancomycin-and-novel-urinary-biomarkers-of-acute-kidney-injury
#9
J Nicholas O'Donnell, Nathaniel J Rhodes, Thomas P Lodise, Walter C Prozialeck, Cristina M Miglis, Medha Joshi, Natarajan Venkatesan, Gwendolyn Pais, Cameron Cluff, Peter C Lamar, Seema Briyal, John Z Day, Anil Gulati, Marc H Scheetz
Introduction: Vancomycin has been associated with acute kidney injury in preclinical and clinical settings, however the precise exposure profiles associated with vancomycin induced acute kidney injury has not been defined. We sought to determine pharmacokinetic/pharmacodynamics indices associated with the development of acute kidney injury using sensitive urinary biomarkers.Methods: Male Sprague-Dawley rats received clinical grade vancomycin or normal saline as an intraperitoneal injection. Total daily doses between 0 and 400 mg/kg/day were administered as single or 2 divided doses over a 24-hour period...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28807024/society-for-immunotherapy-of-cancer-consensus-statement-on-immunotherapy-for-the-treatment-of-bladder-carcinoma
#10
Ashish M Kamat, Joaquim Bellmunt, Matthew D Galsky, Badrinath R Konety, Donald L Lamm, David Langham, Cheryl T Lee, Matthew I Milowsky, Michael A O'Donnell, Peter H O'Donnell, Daniel P Petrylak, Padmanee Sharma, Eila C Skinner, Guru Sonpavde, John A Taylor, Prasanth Abraham, Jonathan E Rosenberg
The standard of care for most patients with non-muscle-invasive bladder cancer (NMIBC) is immunotherapy with intravesical Bacillus Calmette-Guérin (BCG), which activates the immune system to recognize and destroy malignant cells and has demonstrated durable clinical benefit. Urologic best-practice guidelines and consensus reports have been developed and strengthened based on data on the timing, dose, and duration of therapy from randomized clinical trials, as well as by critical evaluation of criteria for progression...
August 15, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28805644/weak-links-how-colonies-counter-the-social-costs-of-individual-variation-in-thermal-physiology
#11
REVIEW
Kaitlin M Baudier, Sean O'Donnell
Social insect nestmates often differ in thermal tolerance (the range of temperatures at which an individual functions). Worker thermal physiology can covary with body size, development, genetics and gene expression. Because colonies rely on the integration of diverse colony members, individual thermal tolerance differences can affect group performance. The weak link hypothesis states that if workers differ in thermal sensitivity, then in variable thermal environments colonies can incur performance costs due to thermal stress effects on the most thermally sensitive worker types...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28805639/development-and-evolution-of-brain-allometry-in-wasps-vespidae-size-ecology-and-sociality
#12
REVIEW
Sean O'Donnell, Susan Bulova
We review research on brain development and brain evolution in the wasp family Vespidae. Basic vespid neuroanatomy and some aspects of functional neural circuitry are well-characterized, and genomic tools for exploring brain plasticity are being developed. Although relatively modest in terms of species richness, the Vespidae include species spanning much of the known range of animal social complexity, from solitary nesters to highly eusocial species with some of the largest known colonies and multiple reproductives...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28803934/doses-durations-and-gender-predict-vancomycin-induced-kidney-injury-in-pre-clinical-studies
#13
J Nicholas O'Donnell, Nathaniel J Rhodes, Cristina M Miglis, Lejla Catovic, Jiajun Liu, Cameron Cluff, Gwen Pais, Sean Avedissian, Medha Joshi, Brooke Griffin, Walter Prozialeck, Anil Gulati, Thomas P Lodise, Marc H Scheetz
Background While vancomycin's exposure-dependent efficacy thresholds have been probed, less is known regarding acute kidney injury (AKI) thresholds for vancomycin. Sensitive urinary biomarkers such as Kidney injury molecule 1 (KIM-1) have shown high sensitivity and specificity for vancomycin-associated AKI. We sought to determine if dose-response curves existed with urinary KIM-1. Secondarily, we sought to evaluate the impact of therapy duration and gender status on observed relationships. Methods A systematic review was conducted via PubMed/MEDLINE...
August 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28802248/utility-of-rapid-whole-exome-sequencing-in-the-diagnosis-of-neonatal-niemann-pick-disease-type-c-presenting-with-fetal-hydrops-and-liver-failure
#14
Mersedeh Rohanizadegan, Sarah El-Almery, Anne O'Donnell-Luria, Ivana Mihalek, Peggy Chen, Marilyn Sanders, Kristen Leeman, Megan Cho, Christina Hung, Olaf Bodamer
Rapid whole exome sequencing (rWES) is increasingly used in critically ill newborn infants to inform about diagnosis, clinical management and prognosis. Here we report a male newborn infant with hydrops, pancytopenia and acute liver failure who was listed for liver transplantation. Given the acuity of the presentation, the procedure related morbidity and mortality and lack of diagnosis we employed rWES in the proband and both parents with a turn-around time of 10 business days. rWES returned one maternally inherited, likely pathogenic and one paternally inherited, likely pathogenic variant in NPC1 suggestive of a diagnosis of Niemann Pick disease type C (NPC)...
August 11, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28801026/quadruple-immunotherapy-of-bacillus-calmette-gu%C3%A3-rin-interferon-interleukin-2-and-granulocyte-macrophage-colony-stimulating-factor-as-salvage-therapy-for-non-muscle-invasive-bladder-cancer
#15
Ryan L Steinberg, Kenneth G Nepple, Kyla N Velaer, Lewis J Thomas, Michael A O'Donnell
BACKGROUND: Bacillus Calmette-Guérin (BCG) is the most effective initial intravesical therapy for high-grade non-muscle invasive bladder cancer, but many patients still fail. Combination intravesical BCG and interferon (IFN) will salvage some patients but results remain suboptimal. OBJECTIVE: We hypothesized that further immunostimulation with intravesical interleukin-2 and subcutaneous granulocyte-macrophage colony-stimulating factor may improve response to intravesical BCG and IFN in patient with prior BCG failure(s)...
August 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28796542/cine-mri-of-tracheal-dynamics-in-healthy-volunteers-and-patients-with-tracheobronchomalacia
#16
Pierluigi Ciet, Phillip M Boiselle, Benedikt Heidinger, Eleni-Rosalina Andrinopoulou, Carl O'Donnel, David C Alsop, Diana E Litmanovich
OBJECTIVE: Bronchoscopy and MDCT are routinely used to assess tracheobronchomalacia (TBM). Recently, dynamic MRI (cine MRI) has been proposed as a radiation-free alternative to MDCT. In this study, we tested cine MRI assessment of airway dynamics during various breathing conditions and compared cine MRI and MDCT measurements in healthy volunteers and patients with suspected TBM. CONCLUSION: Cine MRI was found to be a technically feasible alternative to MDCT for assessing central airway dynamics...
August 10, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28794277/modulation-of-social-space-by-dopamine-in-drosophila-melanogaster-but-no-effect-on-the-avoidance-of-the-drosophila-stress-odorant
#17
Robert W Fernandez, Adesanya A Akinleye, Marat Nurilov, Omar Feliciano, Matthew Lollar, Rami R Aijuri, Janis M O'Donnell, Anne F Simon
Appropriate response to others is necessary for social interactions. Yet little is known about how neurotransmitters regulate attractive and repulsive social cues. Using genetic and pharmacological manipulations in Drosophila melanogaster, we show that dopamine is contributing the response to others in a social group, specifically, social spacing, but not the avoidance of odours released by stressed flies (dSO). Interestingly, this dopamine-mediated behaviour is prominent only in the day-time, and its effect varies depending on tissue, sex and type of manipulation...
August 2017: Biology Letters
https://www.readbyqxmd.com/read/28794135/pulmonary-vasodilator-therapy-is-associated-with-greater-survival-in-eisenmenger-syndrome
#18
Clare Arnott, Geoff Strange, Andrew Bullock, Adrienne C Kirby, Clare O'Donnell, Dorothy J Radford, Leeanne E Grigg, David S Celermajer
OBJECTIVE: Eisenmenger syndrome (ES) is a severe form of pulmonary hypertension in adults with congenital heart disease (CHD) and has a poor prognosis. We aimed to understand factors associated with survival in ES and particularly to assess the potential benefits of advanced pulmonary vasodilator therapy (AT). METHODS: From January 2004, when AT became generally available for patients with ES, we followed 253 ES adults from 12 adult congenital heart disease centres across Australia and New Zealand...
August 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28792618/long-term-outcome-of-dogs-treated-with-ulnar-rollover-transposition-for-limb-sparing-of-distal-radial-osteosarcoma-27-limbs-in-26-dogs
#19
Bernard Séguin, Matthew D O'Donnell, Peter J Walsh, Laura E Selmic
OBJECTIVE: To determine outcomes in dogs with distal radial osteosarcoma treated with ulnar rollover transposition (URT) limb-sparing surgery including: viability of the ulnar graft, complications, subjective limb function, disease-free interval (DFI), and survival time (ST). STUDY DESIGN: Retrospective case series. ANIMALS: Twenty-six client-owned dogs with distal radial osteosarcoma and no involvement of the ulna. METHODS: Data of dogs treated with URT were collected at the time of surgery and retrospectively from medical records and by contacting owners and referring veterinarians...
August 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28782535/alpha-melanocyte-stimulating-hormone-induced-anorexia-in-japanese-quail-coturnix-japonica-likely-involves-the-ventromedial-hypothalamus-and-paraventricular-nucleus-of-the-hypothalamus
#20
Taylor Lear, Lingbin Liu, Madison O'Donnell, Betty R McConn, D Michael Denbow, Mark A Cline, Elizabeth R Gilbert
Alpha-melanocyte stimulating hormone (α-MSH) reduces food intake in birds and mammals. The objective of this experiment was to determine effects of α-MSH on food and water intake, and hypothalamic c-Fos immunoreactivity and appetite-associated factor mRNA in Japanese quail (Coturnix japonica), a species that has not undergone the same artificial selection for growth-related traits as the chicken. At 7days post-hatch, 3-h-fasted quail were intracerebroventricularly (ICV) injected into the lateral ventricle with 0 (vehicle), 0...
August 4, 2017: General and Comparative Endocrinology
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