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https://www.readbyqxmd.com/read/29026071/arginine-methylation-catalyzed-by-prmt1-is-required-for-b-cell-activation-and-differentiation
#1
Simona Infantino, Amanda Light, Kristy O'Donnell, Vanessa Bryant, Danielle T Avery, Michael Elliott, Stuart G Tangye, Gabrielle Belz, Fabienne Mackay, Stephane Richard, David Tarlinton
Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of the Prmt1 gene in mature B cells establishes that although the frequency and phenotype of peripheral B cell subsets seem unaffected, immune responses to T-cell-dependent and -independent antigens are substantially reduced...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29024788/thermostability-of-the-coating-antigen-and-immunostimulator-in-an-adjuvanted-oral-capsule-vaccine-formulation
#2
Stephanie Longet, Vincenzo Aversa, Daire O'Donnell, Joshua Tobias, Monica Rosa, Jan Holmgren, Ivan S Coulter, Ed C Lavelle
Oral vaccines present an attractive alternative to injectable vaccines for enteric diseases due to ease of delivery and the induction of intestinal immunity at the site of infection. However, susceptibility to gastrointestinal proteolysis, limited transepithelial uptake and a lack of clinically acceptable adjuvants present significant challenges. A further challenge to mass vaccination in developing countries is the very expensive requirement to maintain the cold chain. We recently described the effectiveness of a Single Multiple Pill(®) (SmPill(®)) adjuvanted capsule approach to enhance the effectiveness of a candidate enterotoxigenic Escherichia coli (ETEC) oral vaccine...
October 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29024302/reduced-electroencephalogram-responses-to-standard-and-target-auditory-stimuli-in-bipolar-disorder-and-the-impact-of-psychotic-features-analysis-of-event-related-potentials-spectral-power-and-inter-trial-coherence
#3
Nancy B Lundin, Lisa A Bartolomeo, Brian F O'Donnell, William P Hetrick
BACKGROUND: Bipolar disorder (BD) is associated with reductions in the P3b event-related potential (ERP) response to target auditory stimuli, which suggests deficits in context updating. Previous studies have typically examined these responses in the temporal domain, which may not capture alterations in specific frequencies of phase-locked or induced electrophysiological activity. Therefore, the present study examined early and late ERPs in temporal and frequency domains in a bipolar sample with and without current psychotic features...
October 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29023839/effectiveness-of-a-brief-home-parenting-intervention-for-reducing-early-sexual-risks-among-latino-adolescents-salud-y-%C3%A3-xito
#4
Lydia O'Donnell, Shai Fuxman
BACKGROUND: Teen pregnancy rates and related risks remain elevated among Latino teens. We tested the impact on youth sexual behaviors of a brief, culturally targeted, bilingual media intervention designed for parents of young adolescents. METHODS: Salud y éxito (Health & Success) uses dramatic audio stories to model positive parenting practices. After completing classroom surveys, 27 urban schools in the Northeast and Southwest serving low-income Latino communities were randomized so that all families of seventh grade students were sent either: (1) booklets on healthy eating and exercise; (2) Salud-50, where families either received booklets or the intervention, or (3) Salud-100, where all families received the intervention...
November 2017: Journal of School Health
https://www.readbyqxmd.com/read/29022412/photo-sharing-social-media-for-ehealth-analysing-perceived-message-effectiveness-of-sexual-health-information-on-instagram
#5
Nicole Hummel O'Donnell, Jessica Fitts Willoughby
Health professionals increasingly use social media to communicate health information, but it is unknown how visual message presentation on these platforms affects message reception. This study used an experiment to analyse how young adults (n = 839) perceive sexual health messages on Instagram. Participants were exposed to one of four conditions based on visual message presentation. Messages with embedded health content had the highest perceived message effectiveness ratings. Additionally, message sensation value, attitudes and systematic information processing were significant predictors of perceived message effectiveness...
October 12, 2017: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/29019321/beyond-excitation-inhibition-imbalance-in-multidimensional-models-of-neural-circuit-changes-in-brain-disorders
#6
Cian O'Donnell, J Tiago Gonçalves, Carlos Portera-Cailliau, Terrence J Sejnowski
A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here we combined computational simulations with analysis of in vivo 2-photon Ca(2+) imaging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance theory. We found that: 1) The E/I imbalance model cannot account for joint alterations in the observed neural firing rates and correlations; 2) Neural circuit function is vastly more sensitive to changes in some cellular components over others; 3) The direction of circuit alterations in Fmr1 KO mice changes across development...
October 11, 2017: ELife
https://www.readbyqxmd.com/read/29016898/to-the-editor
#7
Jeremy I Simon, Harla K O'Donnell, Zachary Broyer
No abstract text is available yet for this article.
August 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28993608/cascading-effects-of-thermally-induced-anemone-bleaching-on-associated-anemonefish-hormonal-stress-response-and-reproduction
#8
Ricardo Beldade, Agathe Blandin, Rory O'Donnell, Suzanne C Mills
Organisms can behaviorally, physiologically, and morphologically adjust to environmental variation via integrative hormonal mechanisms, ultimately allowing animals to cope with environmental change. The stress response to environmental and social changes commonly promotes survival at the expense of reproduction. However, despite climate change impacts on population declines and diversity loss, few studies have attributed hormonal stress responses, or their regulatory effects, to climate change in the wild. Here, we report hormonal and fitness responses of individual wild fish to a recent large-scale sea warming event that caused widespread bleaching on coral reefs...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28993264/sensory-mechanical-effects-of-a-dual-bronchodilator-and-its-anticholinergic-component-in-copd
#9
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, J Alberto Neder, Katherine A Webb
This randomized, double-blind, crossover study examined the physiological rationale for using a dual long-acting bronchodilator (umeclidinium/vilanterol (UME/VIL)) versus its muscarinic-antagonist component (UME) as treatment for dyspnea and exercise intolerance in moderate COPD. After each 4-week treatment period, subjects performed pulmonary function and symptom-limited constant-work rate cycling tests with diaphragm electromyogram (EMGdi), esophageal (Pes), gastric (Pga) and transdiaphragmatic (Pdi) pressure measurements...
October 6, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28987465/implications-of-iterative-communication-for-biological-system-performance
#10
Michael P O'Connor, Sean O'Donnell
The performance of integrated biological systems can often be described by the behavior of component subunits: the proportion of subunits performing an activity, and the rate of recruitment to the activity, can be relevant to system performance. We develop a model for activation of subunits (receivers) to a task when activation requires repeated signals (iterative communication). The model predicts how system performance will be affected by the parameters of iterative communication. Receiver activation is influenced by the frequency of stimulation, by forgetting about past interactions, and by the number of stimuli needed to activate the receivers...
October 4, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28985842/increased-population-of-immature-enteric-glial-cells-in-the-resected-proximal-ganglionic-bowel-of-hirschsprung-s-disease-patients
#11
Gakuto Tani, Christian Tomuschat, Anne Marie O'Donnell, David Coyle, Prem Puri
BACKGROUND: Enteric glial cells are essential for normal gastrointestinal function. Abnormalities in glial structure, development, or function lead to disturbances in gastrointestinal physiology. Fatty acid-binding protein 7 (FABP7) is a marker of immature enteric glial cells, whereas S100 is expressed only by mature glial cells. Patients with Hirschsprung's disease (HSCR) often suffer from dysmotility and enterocolitis despite proper surgery. We designed this study to determine the distribution and expression of glial cells in patients with HSCR compared to normal controls...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28981505/hepatitis-b-virus-infection-as-a-neglected-tropical-disease
#12
Geraldine A O'Hara, Anna L McNaughton, Tongai Maponga, Pieter Jooste, Ponsiano Ocama, Roma Chilengi, Jolynne Mokaya, Mitchell I Liyayi, Tabitha Wachira, David M Gikungi, Lela Burbridge, Denise O'Donnell, Connie S Akiror, Derek Sloan, Judith Torimiro, Louis Marie Yindom, Robert Walton, Monique Andersson, Kevin Marsh, Robert Newton, Philippa C Matthews
No abstract text is available yet for this article.
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28978499/developing-social-media-based-suicide-prevention-messages-in-partnership-with-young-people-exploratory-study
#13
Jo Robinson, Eleanor Bailey, Sarah Hetrick, Steve Paix, Matt O'Donnell, Georgina Cox, Maria Ftanou, Jaelea Skehan
BACKGROUND: Social media is increasingly being used by young people for health-related issues, including communicating about suicide. Due to the concerns about causing distress or inducing suicidal thoughts or behaviors, to date young people neither have been engaged in the development of social media-based suicide prevention interventions nor have interventions focused on educating young people about safe ways to communicate about suicide online. Given the potential that social media holds to deliver messages to vast numbers of people across space and time and the fact that young people often prefer to seek help from their friends and peers, safely educating and engaging young people to develop suicide prevention messages that can be delivered via social media is an obvious next step...
October 4, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28978344/the-expect-examining-exercise-prostate-cancer-and-circulating-tumour-cells-trial-study-protocol-for-a-randomised-controlled-trial
#14
Gráinne Sheill, Lauren Brady, Emer Guinan, Brian Hayes, Orla Casey, John Greene, Tatjana Vlajnic, Fidelma Cahill, Mieke Van Hemelrijck, Nicola Peat, Sarah Rudman, Juliette Hussey, Moya Cunningham, Liam Grogan, Thomas Lynch, Rustom P Manecksha, John McCaffrey, Lorelei Mucci, Orla Sheils, John O'Leary, Dearbhaile M O'Donnell, Ray McDermott, Stephen Finn
BACKGROUND: Prostate cancer (PrCa) is the second most common cancer in Ireland. Many men present with locally advanced or metastatic cancer for whom curative surgery is inappropriate. Advanced cancer patients are encouraged to remain physically active and therefore there is a need to investigate how patients with metastatic disease tolerate physical activity programmes. Physical activity reduces levels of systemic inflammatory mediators and so an aerobic exercise intervention may represent an accessible and cost-effective means of ameliorating the pro-inflammatory effects of obesity and subsequently decrease poor cancer-specific outcomes in this patient population...
October 4, 2017: Trials
https://www.readbyqxmd.com/read/28975197/association-of-multiorgan-computed-tomographic-phenomap-with-adverse-cardiovascular-health-outcomes-the-framingham-heart-study
#15
Ravi V Shah, Ashish S Yeri, Venkatesh L Murthy, Joe M Massaro, Ralph D'Agostino, Jane E Freedman, Michelle T Long, Caroline S Fox, Saumya Das, Emelia J Benjamin, Ramachandran S Vasan, Christopher J O'Donnell, Udo Hoffmann
Importance: Increased ability to quantify anatomical phenotypes across multiple organs provides the opportunity to assess their cumulative ability to identify individuals at greatest susceptibility for adverse outcomes. Objective: To apply unsupervised machine learning to define the distribution and prognostic importance of computed tomography-based multiorgan phenotypes associated with adverse health outcomes. Design, Setting, and Participants: This asymptomatic community-based cohort study included 2924 Framingham Heart Study participants between July 2002 and April 2005 undergoing computed tomographic imaging of the chest and abdomen...
September 20, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28974106/the-effectiveness-of-the-nurse-care-coordinator-role-on-patient-reported-and-health-service-outcomes-a-systematic-review
#16
Aaron Conway, Chris O'Donnell, Patsy Yates
This systematic review examined the effectiveness of nurse care coordinator (CC) roles on patient-reported and health service outcomes. Multiple electronic databases (Medline, CINAHL, and EMBASE) were searched and the Cochrane Risk of Bias Assessment Tool was applied by two independent reviewers. The Grades of Recommendation, Assessment, Development, and Evaluation system was used to assess the quality of evidence. A total of 45 articles (reporting on 36 studies) were included. The majority of studies ( n = 28, 78%) were conducted in the United States and published after 2009 ( n = 24, 67%)...
January 1, 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/28971906/favorable-impact-of-allogeneic-stem-cell-transplantation-in-patients-with-therapy-related-myelodysplasia-regardless-of-tp53-mutational-status
#17
Ibrahim Aldoss, Anh Pham, Sierra Min Li, Ketevan Gendzekhadze, Michelle Afkhami, Mihan Telatar, Hao Hong, Abbas Padeganeh, Victoria Bedell, Thai Cao, Samer K Khaled, Monzr M Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Joycelynne Palmer, Patricia Aoun, Ricardo Spielberger, Anthony S Stein, David Snyder, Margaret R O'Donnell, Joyce Murata-Collins, David Senitzer, Dennis Weisenburger, Stephen J Forman, Vinod Pullarkat, Guido Marcucci, Raju Pillai, Ryotaro Nakamura
Therapy-related myelodysplastic syndrome (t-MDS) is a long-term complication of cancer treatment for patients receiving cytotoxic therapy, characterized by high-risk genetics and poor outcomes. Allogeneic hematopoietic cell transplantation represents the only curative modality for t-MDS, but the prognostic impact of pre-transplant genetics and clinical features has not yet been fully characterized. We report here the genetic, clinical characteristics and outcomes of a relatively large cohort of t-MDS patients (n=67) who received alloHCT compared to similarly treated patients with de novo MDS (n=199)...
September 29, 2017: Haematologica
https://www.readbyqxmd.com/read/28970461/development-and-implementation-of-a-global-health-elective-with-a-drug-discovery-game-for-pharmacy-students
#18
Jordan R Covvey, Anthony J Guarascio, Lauren A O'Donnell, Kevin J Tidgewell
Interest in global health education within the pharmacy curriculum has increased significantly in recent years. However, discussion of different models and methods to evaluate course structures are limited. The overall objective was to (1) describe the structure of our global health elective for pharmacy students, and (2) assess educational outcomes related to perceived/formal knowledge and attitudes associated with global health. Our elective was designed using a competency-centered approach to global health education, incorporating reflection, projects, service and game-learning...
August 28, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28967485/first-line-pembrolizumab-in-cisplatin-ineligible-patients-with-locally-advanced-and-unresectable-or-metastatic-urothelial-cancer-keynote-052-a-multicentre-single-arm-phase-2-study
#19
Arjun V Balar, Daniel Castellano, Peter H O'Donnell, Petros Grivas, Jacqueline Vuky, Thomas Powles, Elizabeth R Plimack, Noah M Hahn, Ronald de Wit, Lei Pang, Mary J Savage, Rodolfo F Perini, Stephen M Keefe, Dean Bajorin, Joaquim Bellmunt
BACKGROUND: More than half of all patients with advanced urothelial cancer cannot receive standard, first-line cisplatin-based chemotherapy because of renal dysfunction, poor performance status, or other comorbidities. We assessed the activity and safety of first-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer. METHODS: In this multicentre, single-arm, phase 2 study (KEYNOTE-052), cisplatin-ineligible patients with advanced urothelial cancer who had not been previously treated with systemic chemotherapy were recruited from 91 academic medical centres in 20 countries...
September 26, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28965820/ct-imaging-of-chronic-obstructive-pulmonary-disease-insights-disappointments-and-promise
#20
George R Washko, Harvey O Coxson, Denis E O'Donnell, Shawn D Aaron
CT imaging is a readily quantifiable tool that can provide in-vivo assessments of lung structure in conditions such as chronic obstructive pulmonary disease (COPD). The information extracted from these data has been used in many clinical, epidemiological, and genetic investigations for patient stratification and prognostication, and to determine intermediate endpoints for clinical trials. Although these efforts have informed our understanding of the heterogeneity of pulmonary disease in smokers, they have not yet translated into new treatments for COPD or the personalisation of patient care...
September 28, 2017: Lancet Respiratory Medicine
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