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https://www.readbyqxmd.com/read/28548545/mild-chronic-obstructive-pulmonary-disease-why-spirometry-is-not-sufficient
#1
Amany F Elbehairy, Grace Parraga, Katherine A Webb, J Alberto Neder, Denis E O'Donnell
Chronic obstructive pulmonary disease (COPD) - an inflammatory disease of the airways, alveoli and lung microvasculature - is a leading cause of death worldwide. Smokers with milder airway obstruction constitute the majority of patients with this disease. Many studies have shown increased morbidity, activity-related dyspnea, exercise intolerance and mortality in such patients, compared with age-matched healthy populations. Clinical evaluation of symptomatic smokers with ostensibly mild airway obstruction poses a challenge in clinical practice as spirometry can obscure extensive heterogeneous pathophysiological impairment...
May 26, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28545846/is-diabetes-self-management-education-still-the-cinderella-of-diabetes-care
#2
Lorna Hurley, Máire O'Donnell, Mary Clare O'Hara, Marian E Carey, Ingrid Willaing, Heather Daly, Seán F Dinneen
This paper reflects on the status of diabetes self-management education (DSME) as a branch of diabetology in Europe and discusses some opportunities for better supporting DSME delivery. DSME (also commonly known as Therapeutic Patient Education) has been evolving as a therapy for diabetes for decades. As a continent, Europe is fortunate to have nurtured many pioneers in DSME, and currently has many experts in the field progressing the knowledge base and striving to improve access to DSME for people with diabetes...
May 17, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28542321/early-protection-events-in-swine-immunized-with-an-experimental-live-attenuated-classical-swine-fever-marker-vaccine-flagt4g
#3
Lauren G Holinka, Vivian O'Donnell, Guillermo R Risatti, Paul Azzinaro, Jonathan Arzt, Carolina Stenfeldt, Lauro Velazquez-Salinas, Jolene Carlson, Douglas P Gladue, Manuel V Borca
Prophylactic vaccination using live attenuated classical swine fever (CSF) vaccines has been a very effective method to control the disease in endemic regions and during outbreaks in previously disease-free areas. These vaccines confer effective protection against the disease at early times post-vaccination although the mechanisms mediating the protection are poorly characterized. Here we present the events occurring after the administration of our in-house developed live attenuated marker vaccine, FlagT4Gv...
2017: PloS One
https://www.readbyqxmd.com/read/28539185/frequency-of-untreated-hypogammaglobulinemia-in-bronchiectasis
#4
Melanie A Ruffner, Timothy R Aksamit, Byron Thomashow, Radmila Choate, Angela DiMango, Gerard M Turino, Anne E O'Donnell, Margaret M Johnson, Kenneth N Olivier, Kevin Fennelly, Charles L Daley, Kevin L Winthrop, Mark L Metersky, Matthias A Salathe, Michael R Knowles, M Leigh Anne Daniels, Peadar G Noone, Gregory Tino, David E Griffith, Kathleen E Sullivan
No abstract text is available yet for this article.
May 20, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28536122/jonathan-kagan-a-cell-biologist-s-view-of-immunity
#5
Marie Anne O'Donnell
Kagan studies how organelles control innate immunity.
May 23, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28535839/separation-from-parents-during-childhood-trauma-predicts-adult-attachment-security-and-post-traumatic-stress-disorder
#6
R A Bryant, M Creamer, M O'Donnell, D Forbes, K L Felmingham, D Silove, G Malhi, M van Hoof, A C McFarlane, A Nickerson
BACKGROUND: Prolonged separation from parental support is a risk factor for psychopathology. This study assessed the impact of brief separation from parents during childhood trauma on adult attachment tendencies and post-traumatic stress. METHOD: Children (n = 806) exposed to a major Australian bushfire disaster in 1983 and matched controls (n = 725) were assessed in the aftermath of the fires (mean age 7-8 years) via parent reports of trauma exposure and separation from parents during the fires...
May 24, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28534880/a-tale-of-two-risks-smoking-diabetes-and-the-subgingival-microbiome
#7
Sukirth M Ganesan, Vinayak Joshi, Megan Fellows, Shareef M Dabdoub, Haikady N Nagaraja, Benjamin O'Donnell, Neeta Rohit Deshpande, Purnima S Kumar
Although smoking and diabetes have been established as the only two risk factors for periodontitis, their individual and synergistic impacts on the periodontal microbiome are not well studied. The present investigation analyzed 2.7 million 16S sequences from 175 non-smoking normoglycemic individuals (controls), smokers, diabetics and diabetic smokers with periodontitis as well as periodontally healthy controls, smokers and diabetics to assess subgingival bacterial biodiversity and co-occurrence patterns. The microbial signatures of periodontally healthy smokers, but not diabetics, were highly aligned with the disease-associated microbiomes of their respective cohorts...
May 23, 2017: ISME Journal
https://www.readbyqxmd.com/read/28533532/beyond-rcts-in-public-health-policy-research-who-s-the-fairest-of-them-all
#8
Elena N Naumova
The article in this issue by O'Donnell et al stimulated my attention to the methods beyond randomized controlled trials that can help assess public health research and rank its utility in hierarchies of evidence. The future of public health policy research will surely combine computational power and the power of human ingenuity.
May 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28530670/transfusion-practices-for-bone-marrow-harvests-a-survey-analysis-from-the-aabb-bone-marrow-quality-improvement-initiative-working-group
#9
T R Spitzer, M W Sugrue, C Gonzalez, P O'Donnell, D Confer, E Fuchs, M A Pulsipher, J Schwartz, M Linenberger
No abstract text is available yet for this article.
May 22, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28526950/the-effect-of-post-mortem-computed-tomography-angiography-pmcta-using-water-soluble-iodine-based-radiographic-contrast-on-histological-analysis-of-the-liver-kidneys-and-left-ventricle-of-the-heart
#10
Samantha Higgins, Sarah Parsons, Noel Woodford, Matthew Lynch, Christopher Briggs, Chris O'Donnell
The purpose of this study was to investigate the impact of post-mortem computed-tomography angiography (PMCTA) on the histology of the liver, kidneys and heart. Multiple tissue cores were collected from the liver, left and right kidneys and left ventricle utilizing CT-guided biopsy. Subsequent whole body PMCTA was performed using a solution of polyethylene glycol and iodinated radiographic contrast, and an embalming pump. Corresponding biopsy cores were collected at autopsy, and blinded histology analysis assessing for PMCTA-induced histology artefact was performed...
May 20, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28518168/using-high-resolution-variant-frequencies-to-empower-clinical-genome-interpretation
#11
Nicola Whiffin, Eric Minikel, Roddy Walsh, Anne H O'Donnell-Luria, Konrad Karczewski, Alexander Y Ing, Paul J R Barton, Birgit Funke, Stuart A Cook, Daniel MacArthur, James S Ware
PurposeWhole-exome and whole-genome sequencing have transformed the discovery of genetic variants that cause human Mendelian disease, but discriminating pathogenic from benign variants remains a daunting challenge. Rarity is recognized as a necessary, although not sufficient, criterion for pathogenicity, but frequency cutoffs used in Mendelian analysis are often arbitrary and overly lenient. Recent very large reference datasets, such as the Exome Aggregation Consortium (ExAC), provide an unprecedented opportunity to obtain robust frequency estimates even for very rare variants...
May 18, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28513743/adsorption-differences-between-low-coverage-enantiomers-of-alanine-on-the-chiral-cu-421-r-surface
#12
Michael J Gladys, Jeong Woo Han, Therese S Pedersen, Anton Tadich, Kane M O'Donnell, Lars Thomsen
Chiral separation using heterogeneous methods has long been sought after. Chiral metal surfaces have the potential to make it possible to model these systems using small amino acids, the building blocks for proteins. A comparison of submonolayer concentrations of alanine enantiomers adsorbed onto Cu{421}(R) has revealed a large geometrical differences between the two molecules as compared to the saturated coverage. Large differences were observed in HR-XPS and NEXAFS and complemented by theoretical DFT calculations...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28506476/adherence-to-lipid-management-guidelines-is-associated-with-lower-mortality-and-major-adverse-limb-events-in-patients-undergoing-revascularization-for-chronic-limb-threatening-ischemia
#13
Thomas F X O'Donnell, Sarah E Deery, Jeremy D Darling, Katie E Shean, Murray A Mittleman, Gabrielle N Yee, Matthew R Dernbach, Marc L Schermerhorn
OBJECTIVE: The 2013 American College of Cardiology/American Heart Association lipid management guidelines recommend high-intensity statins for all patients ≤75 years old with chronic limb-threatening ischemia (CLTI) and moderate-intensity statins for CLTI patients >75 years old without contraindications or on dialysis, but these recommendations are based primarily on coronary and stroke data. We aimed to validate these guidelines in patients with CLTI and to assess current adherence to these recommendations...
May 12, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28505190/dynamic-interaction-between-fetal-adversity-and-a-genetic-score-reflecting-dopamine-function-on-developmental-outcomes-at-36-months
#14
Adrianne R Bischoff, Irina Pokhvisneva, Étienne Léger, Hélène Gaudreau, Meir Steiner, James L Kennedy, Kieran J O'Donnell, Josie Diorio, Michael J Meaney, Patrícia P Silveira
BACKGROUND: Fetal adversity, evidenced by poor fetal growth for instance, is associated with increased risk for several diseases later in life. Classical cut-offs to characterize small (SGA) and large for gestational age (LGA) newborns are used to define long term vulnerability. We aimed at exploring the possible dynamism of different birth weight cut-offs in defining vulnerability in developmental outcomes (through the Bayley Scales of Infant and Toddler Development), using the example of a gene vs...
2017: PloS One
https://www.readbyqxmd.com/read/28505000/h3f3a-histone-3-3-g34w-immunohistochemistry-a-reliable-marker-defining-benign-and-malignant-giant-cell-tumor-of-bone
#15
Fernanda Amary, Fitim Berisha, Hongtao Ye, Manu Gupta, Alice Gutteridge, Daniel Baumhoer, Rebecca Gibbons, Roberto Tirabosco, Paul O'Donnell, Adrienne M Flanagan
Giant cell tumor of bone (GCTB) is a locally aggressive subarticular tumor. Having recently reported that H3.3 G34W mutations are characteristic of this tumor type, we have now investigated the sensitivity and specificity of the anti-histone H3.3 G34W rabbit monoclonal antibody in a wide variety of tumors including histologic mimics of GCTB to assess its value as a diagnostic marker. We also determined the incidence of H3.3 G34 mutations in primary malignant bone tumors as assessed by genotype and H3.3 G34W immunostaining...
May 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28504911/the-value-of-sharing-information-a-neural-account-of-information-transmission
#16
Elisa C Baek, Christin Scholz, Matthew Brook O'Donnell, Emily B Falk
Humans routinely share information with one another. What drives this behavior? We used neuroimaging to test an account of information selection and sharing that emphasizes inherent reward in self-reflection and connecting with other people. Participants underwent functional MRI while they considered personally reading and sharing New York Times articles. Activity in neural regions involved in positive valuation, self-related processing, and taking the perspective of others was significantly associated with decisions to select and share articles, and scaled with preferences to do so...
May 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28501827/a-confirmed-case-of-sugammadex-induced-anaphylaxis-in-a-uk-hospital
#17
Robert O'Donnell, Jack Hammond, Sam Soltanifar
We report the first published case of confirmed anaphylaxis to sugammadex in a UK hospital. The patient was given a bolus of sugammadex at the end of surgery. Four minutes later, he developed hypotension and a widespread erythematous rash. Multiple epinephrine boluses were administered and a continuous intravenous infusion of epinephrine commenced. The patient later reported auditory awareness, which occurred while the diagnosis of anaphylaxis was being made and initial treatment initiated. Serial serum tryptase levels were consistent with a type I hypersensitivity reaction...
May 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28499036/potential-of-a-northern-population-of-aedes-vexans-diptera-culicidae-to-transmit-zika-virus
#18
Kyle L O'Donnell, Mckenzie A Bixby, Kelsey J Morin, David S Bradley, Jefferson A Vaughan
Zika virus is an emerging arbovirus of humans in the western hemisphere. With its potential spread into new geographical areas, it is important to define the vector competence of native mosquito species. We tested the vector competency of Aedes vexans (Meigen) from the Lake Agassiz Plain of northwestern Minnesota and northeastern North Dakota. Aedes aegypti (L.) was used as a positive control for comparison. Mosquitoes were fed blood containing Zika virus and 2 wk later were tested for viral infection and dissemination...
May 12, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28494518/correlates-of-resistance-and-relapse-during-blinatumomab-therapy-for-relapsed-refractory-acute-lymphoblastic-leukemia
#19
Ibrahim Aldoss, Joo Song, Tracey Stiller, Tina Nguyen, Joycelynne Palmer, Margaret O'Donnell, Anthony S Stein, Guido Marcucci, Stephen Forman, Vinod Pullarkat
We retrospectively analyzed 65 patients with refractory/relapsed (r/r) ALL who were treated with blinatumomab for predictors of leukemia response as well as clinical patterns of relapse and resistance with particular focus on downregulation of CD19 expression and extramedullary disease (EM-ALL). The complete remission (CR) rate was 51%, and 15 (45%) responders underwent allogeneic hematopoietic cell transplantation (HCT) in CR. High leukemia burden (bone marrow blasts >50%) (P=0.02), history of prior EM-ALL (P=0...
May 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28493660/use-of-medication-and-psychological-counselling-among-canadians-with-mood-and-or-anxiety-disorders
#20
Siobhan O'Donnell, Maria Syoufi, Wayne Jones, Kathryn Bennett, Louise Pelletier
INTRODUCTION: This study describes the use of prescription medications and psychological counselling in the past 12 months among Canadian adults with a self-reported mood and/or anxiety disorder diagnosis; the sociodemographic and clinical characteristics associated with their use; and reasons for not using them. METHODS: We used data from the 2014 Survey on Living with Chronic Diseases in Canada-Mood and Anxiety Disorders Component. The study sample (n = 2916) was divided into four treatment subgroups: (1) taking medication only; (2) having received counselling only; (3) both; or (4) neither...
May 2017: Health Promotion and Chronic Disease Prevention in Canada
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