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https://www.readbyqxmd.com/read/29456391/the-use-of-thromboelastography-to-measure-the-influence-inclusion-of-a-local-anesthetic-agent-has-on-the-mechanical-and-kinetic-properties-of-fibrin
#1
Laura Kearney, Derek Whelan, Brian D O'Donnell, Anthony J P Clover
Context: Delivery of slow-release local anesthesia has considerable potential for postoperative analgesia. Fibrin gel has shown huge potential for drug delivery, but has not been fully investigated for the delivery of local anesthetics nor has whether incorporation of anesthetic drugs into fibrin alters its mechanical properties. Aims: This study aimed to evaluate the effects of bupivacaine inclusion on the mechanical and kinetic properties of fibrin as measured by thromboelastography (TEG)...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29448739/bandgap-tunability-of-transition-metal-dichalcogenide-atomic-layers
#2
Quinton Rice, Bagher Tabibi, Felix Jaetae Seo
The temperature-dependent bandgap of transition metal dichalcogenides (TMDCs, MX2; M = Mo or W; X = S, Se, or Te) is analyzed using the O'Donnell and Chen relation with parameters including the average acoustic phonon energy (〈ħω〉) and the electron-phonon coupling strength (s). Wider (narrower) tunability of the bandgap results from the larger (smaller) electron-phonon coupling strength for a constant acoustic phonon energy. A 1.5 eV bandgap change was observed for weak electron-phonon coupling (s = 2) as well as with the strong electron-phonon coupling (s = 30)...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448703/exciton-formation-entropy-changes-in-transition-metal-dichalcogenide-atomic-layers
#3
Quinton Rice, Bagher Tabibi, Felix Jaetae Seo
The atomic layers of transition metal dichalcogenides (TMDCs, MX2; M = Mo or W; X = S, Se, or Te) are of great interest in the areas of photonics and optoelectronics due to the correlation between valley orbital, spin, and optical helicity; the compositional tuning of exciton bandgaps in visible and near-infrared spectra; and the bandgap modification from indirect for bilayer or multilayer to direct for monolayer. The derivative of the O'Donnell and Chen relation is analyzed as a function of temperature and gives the relationship between the change in entropy of exciton formation and the bandgap energy...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29446965/associations-between-coherent-neural-activity-in-the-brain-s-value-system-during-antismoking-messages-and-reductions-in-smoking
#4
Nicole Cooper, Steven Tompson, Matthew B O'Donnell, Jean M Vettel, Danielle S Bassett, Emily B Falk
OBJECTIVE: Worldwide, tobacco use is the leading cause of preventable death and illness. One common strategy for reducing the prevalence of cigarette smoking and other health risk behaviors is the use of graphic warning labels (GWLs). This has led to widespread interest from the perspective of health psychology in understanding the mechanisms of GWL effectiveness. Here we investigated differences in how the brain responds to negative, graphic warning label-inspired antismoking ads and neutral control ads, and we probed how this response related to future behavior...
February 15, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29439648/effect-of-12-weeks-of-once-daily-tiotropium-olodaterol-on-exercise-endurance-during-constant-work-rate-cycling-and-endurance-shuttle-walking-in-chronic-obstructive-pulmonary-disease
#5
François Maltais, Denis O'Donnell, Juan Bautista Gáldiz Iturri, Anne-Marie Kirsten, Dave Singh, Alan Hamilton, Kay Tetzlaff, Yihua Zhao, Richard Casaburi
BACKGROUND: The TORRACTO® study evaluated the effects of tiotropium/olodaterol versus placebo on endurance time during constant work-rate cycling and constant speed shuttle walking in patients with chronic obstructive pulmonary disease (COPD) after 12 weeks of treatment. METHODS: The effects of once-daily tiotropium/olodaterol (2.5/5 and 5/5 μg) on endurance time during constant work-rate cycle ergometry (CWRCE) after 6 and 12 weeks of treatment were compared with placebo in patients with COPD in a randomized, double-blind, placebo-controlled, parallel-group clinical trial...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29438808/effect-of-tiotropium-on-spontaneous-expiratory-flow-volume-curves-during-exercise-in-gold-1-2-copd
#6
Janos Porszasz, Nicolò Carraro, Robert Cao, Ashwani Gore, Shuyi Ma, Thomas Jiang, François Maltais, Gary T Ferguson, Denis E O'Donnell, Asif Shaikh, Harry B Rossiter, Richard Casaburi
This substudy of a large, randomized, controlled trial (NCT01072396) examined tiotropium (18 μg qd) effects on dynamic hyperinflation during constant work rate treadmill exercise. Areas-under-the-spontaneous expiratory flow-volume (SEFV)-curves were compared in 20 COPD patients and 16 age-matched untreated controls, using rectangular area ratio (RAR) between peak intrabreath and end-expiratory flow. Seven patients exhibited SEFV curve concavity with RAR ≤ 0.5 (RAR low ) in ≥1 test without tiotropium; (mean ± SD FEV 1 : 1...
February 10, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29433667/inequalities-in-the-use-of-secondary-prevention-of-cardiovascular-disease-by-socioeconomic-status-evidence-from-the-pure-observational-study
#7
Adrianna Murphy, Benjamin Palafox, Owen O'Donnell, David Stuckler, Pablo Perel, Khalid F AlHabib, Alvaro Avezum, Xiulin Bai, Jephat Chifamba, Clara K Chow, Daniel J Corsi, Gilles R Dagenais, Antonio L Dans, Rafael Diaz, Ayse N Erbakan, Noorhassim Ismail, Romaina Iqbal, Roya Kelishadi, Rasha Khatib, Fernando Lanas, Scott A Lear, Wei Li, Jia Liu, Patricio Lopez-Jaramillo, Viswanathan Mohan, Nahed Monsef, Prem K Mony, Thandi Puoane, Sumathy Rangarajan, Annika Rosengren, Aletta E Schutte, Mariz Sintaha, Koon K Teo, Andreas Wielgosz, Karen Yeates, Lu Yin, Khalid Yusoff, Katarzyna Zatońska, Salim Yusuf, Martin McKee
BACKGROUND: There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. METHODS: We assessed use of antiplatelet, cholesterol, and blood-pressure-lowering drugs in 8492 individuals with self-reported cardiovascular disease from 21 countries enrolled in the Prospective Urban Rural Epidemiology (PURE) study. Defining one or more drugs as a minimal level of secondary prevention, wealth-related inequality was measured using the Wagstaff concentration index, scaled from -1 (pro-poor) to 1 (pro-rich), standardised by age and sex...
March 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29432385/economic-evaluation-of-selective-neonatal-bcg-vaccination-of-high-risk-infants-in-ireland
#8
Conor Teljeur, Patrick S Moran, Patricia Harrington, Karina Butler, Brenda Corcoran, Joan O'Donnell, Cara Usher, Darina O'Flanagan, Kevin Connolly, Máirín Ryan
BACKGROUND: In Western Europe, currently only Ireland and Portugal continue to provide universal neonatal BCG vaccination programmes, despite not being considered as high TB incidence countries. Other European countries only vaccinate infants considered at high risk of contracting TB. We evaluated the cost-effectiveness of selective BCG vaccination compared to strategies of universal and no vaccination. METHODS: An economic model was used to simulate a cohort from birth to life expectancy, taking the perspective of the publicly-funded healthcare system...
February 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29432133/programming-cardiac-resynchronization-therapy-for-electrical-synchrony-reaching-beyond-left-bundle-branch-block-and-left-ventricular-activation-delay
#9
Niraj Varma, David O'Donnell, Mohammed Bassiouny, Philippe Ritter, Carlo Pappone, Jan Mangual, Daniel Cantillon, Nima Badie, Bernard Thibault, Brian Wisnoskey
BACKGROUND: QRS narrowing following cardiac resynchronization therapy with biventricular (BiV) or left ventricular (LV) pacing is likely affected by patient-specific conduction characteristics (PR, qLV, LV-paced propagation interval), making a universal programming strategy likely ineffective. We tested these factors using a novel, device-based algorithm (SyncAV) that automatically adjusts paced atrioventricular delay (default or programmable offset) according to intrinsic atrioventricular conduction...
February 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29431698/mef2c-phosphorylation-is-required-for-chemotherapy-resistance-in-acute-myeloid-leukemia
#10
Fiona C Brown, Eric Still, Richard P Koche, Christina Y Yim, Sumiko Takao, Paolo Cifani, Casie Reed, Shehana Gunasekera, Scott B Ficarro, Peter Romanienko, Willie Mark, Craig McCarthy, Elisa de Stanchina, Mithat Gonen, Venkatraman Seshan, Patrick Bhola, Conor O'Donnell, Barbara Spitzer, Crystal Stutzke, Vincent-Philippe Lavallée, Josée Hébert, Andrei V Krivstov, Ari Melnick, Elisabeth M Paietta, Martin S Tallman, Anthony Letai, Guy Sauvageau, Gayle Pouliot, Ross Levine, Jarrod A Marto, Scott A Armstrong, Alex Kentsis
In acute myeloid leukemia, chemotherapy resistance remains prevalent and poorly understood. Using functional proteomics of patient AML specimens, we identified MEF2C S222 phosphorylation as a specific marker of primary chemoresistance. We found that Mef2c S222A/S222A knock-in mutant mice engineered to block MEF2C phosphorylation exhibited normal hematopoiesis, but were resistant to leukemogenesis induced by MLL-AF9. MEF2C phosphorylation was required for leukemia stem cell maintenance, and induced by MARK kinases in cells...
February 5, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29431458/differential-emotional-processing-in-concrete-and-abstract-words
#11
Bo Yao, Anne Keitel, Gillian Bruce, Graham G Scott, Patrick J O'Donnell, Sara C Sereno
Emotion (positive and negative) words are typically recognized faster than neutral words. Recent research suggests that emotional valence, while often treated as a unitary semantic property, may be differentially represented in concrete and abstract words. Studies that have explicitly examined the interaction of emotion and concreteness, however, have demonstrated inconsistent patterns of results. Moreover, these findings may be limited as certain key lexical variables (e.g., familiarity, age of acquisition) were not taken into account...
February 12, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29429871/case-study-comparison-of-functional-vs-organic-stability-approaches-for-assessing-threat-potential-at-closed-landfills-in-the-usa
#12
Sean T O'Donnell, Michael D Caldwell, Morton A Barlaz, Jeremy W F Morris
Municipal solid waste (MSW) landfills in the USA are regulated under Subtitle D of the Resource Conservation and Recovery Act (RCRA), which includes the requirement to protect human health and the environment (HHE) during the post-closure care (PCC) period. Several approaches have been published for assessment of potential threats to HHE. These approaches can be broadly divided into organic stabilization, which establishes an inert waste mass as the ultimate objective, and functional stability, which considers long-term emissions in the context of minimizing threats to HHE in the absence of active controls...
February 8, 2018: Waste Management
https://www.readbyqxmd.com/read/29423246/the-role-of-the-ligamentum-teres-in-the-adult-hip-redundant-or-relevant-a-review
#13
REVIEW
John M O'Donnell, Brian M Devitt, Manit Arora
The ligamentum teres (LT) has traditionally been described as a redundant structure with no contribution to hip biomechanics or function. There has been renewed interest in the LT as a source of hip pathology due to the high prevalence of LT pathology observed at the time of hip arthroscopy. The LT acts a secondary stabilizer to supplement the work of the capsular ligaments and works in a sling-like manner to prevent subluxation of the hip at the extremes of motion. The presence of free nerve endings within the LT indicates a definite role in pain generation, with the LT undergoing various mechanical and histological adaptations to hip pathology...
January 2018: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29421418/fewer-complications-in-the-obese-following-lower-extremity-endovascular-interventions
#14
Katie E Shean, Sara L Zettervall, Sarah E Deery, Thomas F X O'Donnell, Peter A Soden, Joel M Johnson, Raul J Guzman, Marc L Schermerhorn
BACKGROUND: The prevalence of obesity is increasing in the United States; however its impact on adverse outcomes in patients with peripheral vascular disease is not well studied. Obesity is associated with higher rates of complications following open bypass surgery, but limited data are available on its effect on endovascular intervention. This study aimed to identify whether obese patients suffer the same complications when undergoing lower extremity endovascular interventions. METHODS: All patients who underwent femoropopliteal or tibial endovascular interventions between 2011 and 2013 were identified in the Targeted Vascular Module of the NSQIP...
February 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29417567/breaking-down-barriers-to-effective-patient-care
#15
EDITORIAL
Peter H O'Donnell, Kellie Schoolar Reynolds
The theme for the 2018 ASCPT Annual Meeting is "Breaking Down Barriers to Effective Patient Care." This theme refers to the essential contributions of clinical pharmacology to the development of today's discovery into tomorrow's medicine. The various subdisciplines within clinical pharmacology serve to move molecules through the various stages of drug development and also refine or expand use of the drug postapproval. The wide range of topics covered by the 2018 Annual Meeting scientific program demonstrates the breadth of clinical pharmacology's impact...
March 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29415022/rictor-torc2-mediates-gut-to-brain-signaling-in-the-regulation-of-phenotypic-plasticity-in-c-elegans
#16
Michael P O'Donnell, Pin-Hao Chao, Jan E Kammenga, Piali Sengupta
Animals integrate external cues with information about internal conditions such as metabolic state to execute the appropriate behavioral and developmental decisions. Information about food quality and quantity is assessed by the intestine and transmitted to modulate neuronal functions via mechanisms that are not fully understood. The conserved Target of Rapamycin complex 2 (TORC2) controls multiple processes in response to cellular stressors and growth factors. Here we show that TORC2 coordinates larval development and adult behaviors in response to environmental cues and feeding state in the bacterivorous nematode C...
February 7, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29410743/what-wrist-should-you-wear-your-actigraphy-device-on-analysis-of-dominant-vs-non-dominant-wrist-actigraphy-for-measuring-sleep-in-healthy-adults
#17
Matthew William Driller, Shannon O'Donnell, Francisco Tavares
OBJECTIVE: Differences in sleep results due to the placement of actigraphy devices (non-dominant vs. dominant wrist) are yet to be determined. METHODS: 65 nights of data from 13 adult participants was collected while participants wore two actigraphy devices, one on each wrist. Sleep indices including total sleep time (TST), total time in bed (TTB), sleep efficiency (SE%), sleep latency (SL), wake after sleep onset (WASO), sleep onset time (SOT) and wake time (WT) were assessed between the two devices...
July 2017: Sleep Science
https://www.readbyqxmd.com/read/29410281/minimizing-microbial-contamination-risk-simultaneously-from-multiple-hospital-washbasins-by-automated-cleaning-and-disinfection-of-u-bends-with-electrochemically-activated-solutions
#18
E C Deasy, E M Moloney, M A Boyle, J S Swan, D A Geoghegan, G I Brennan, T E Fleming, M J O'Donnell, D C Coleman
BACKGROUND: Outbreaks of infection associated with microbial biofilm in hospital hand washbasin U-bends are increasingly being reported. In a previous study the efficacy of a prototype automated U-bend decontamination method was demonstrated for a single non-hospital pattern washbasin. It used two electrochemically-activated solutions generated from brine; a catholyte with detergent properties and anolyte with disinfectant properties. AIM: To develop and test a large-scale automated ECA-treatment system to simultaneously decontaminate 10 hospital pattern washbasin U-bends in a busy hospital clinic...
February 1, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29405332/the-eukaryotic-cmg-helicase-at-the-replication-fork-emerging-architecture-reveals-an-unexpected-mechanism
#19
REVIEW
Huilin Li, Michael E O'Donnell
The eukaryotic helicase is an 11-subunit machine containing an Mcm2-7 motor ring that encircles DNA, Cdc45 and the GINS tetramer, referred to as CMG (Cdc45, Mcm2-7, GINS). CMG is "built" on DNA at origins in two steps. First, two Mcm2-7 rings are assembled around duplex DNA at origins in G1 phase, forming the Mcm2-7 "double hexamer." In a second step, in S phase Cdc45 and GINS are assembled onto each Mcm2-7 ring, hence producing two CMGs that ultimately form two replication forks that travel in opposite directions...
February 6, 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29404936/the-impact-of-bariatric-surgery-on-short-term-risk-of-clostridium-difficile-admissions
#20
Hisham Hussan, Emmanuel Ugbarugba, Michael T Bailey, Kyle Porter, Bradley Needleman, Sabrena Noria, Benjamin O'Donnell, Steven K Clinton
BACKGROUND AND AIMS: Clostridium difficile infection (CDI) is major health care concern with reports linking it to obesity. Our aim was to investigate the little known impact of the two most common bariatric surgeries, Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), on risk of CDI admissions. METHODS: This is a retrospective cohort study using the 2013 Nationwide Readmission Database. We examined inpatient CDI rates within 120 days after RYGB (n = 40,059) and VSG (n = 45,394)...
February 5, 2018: Obesity Surgery
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